Bacterias are a class of microorganism consisted of a single cell with a simple internal structure with a number of different shapes.
Not all bacterias are harmful to human. Some are essential to human life, with benefits related to improve the digestive function, prevent overexpression of harmful disease-causing bacteria, and the synthesis of essential nutrients and vitamins.
Believe or not, human gut contains over 10 trillions of bacterias including at least 1000 different species of known bacteria with more than 3 million genes.
In a healthy individual, the levels of microorganisms in the gut are balanced.
The gut microbiota plays a critical role in breaking down foods that stomach and small intestines cannot digest, stimulating the production of vitamin K and D, protecting the intestinal against damage caused by bad bacteria and increasing the immune functioning.
Bacterias that cause disease are called pathogenic microorganisms.
Epidemiological studies suggested that Mycobacterium tuberculosis bacteria is one of the bacteria that causes tuberculosis, killing over 2 million people a year, mostly in sub-Saharan Africa.
Other pathogenic bacterias include Streptococcus and Pseudomonas, and Shigella, Campylobacter, and Salmonella.
According to the statistics, pathogenic bacterial infection is a leading cause of death of infants in developing countries.
On the finding a bioactive ingredient with antibacterial activity, researchers examined allyl isothiocyanate (AIT) is derived from the glucosinolate sinigrin in E. coli O157:H7 numbers in food products.
Injection of AIT showed a greater antimicrobial activity at low pH values. In other words, at pH 4.5 and 5.5 the MIC was 25 microL/L, while at pH 8.5, 500 microL/L was required to inhibit bacterial growth.
Furthermore, bacterial decomposition was found at the highest rate in water at 37 degrees C.
Moreover, in bacterial enzymes (the thioredoxin reductase and acetate kinase), AIT at 10 to 100 microL/L was able to significantly inhibit both enzymes, but only 1 microL/L was needed to decrease the activity of thioredoxin reductase.
Interestingly, in a Nanocomposite carboxymethyl cellulose films tested on Escherichia coli O157:H7-containing sinigrin (SNG) prepared by stirring 2% (w/v) carboxymethyl cellulose (CMC) and 2% (w/v) glycerol (as a plasticizer) in distilled water with or without SNG (an antimicrobial precursor) as a 99% pure reagent (pSNG) or as a crude extract (cSNG), researchers found that
* In beef pieces measuring 6 × 5 × 2 cm(3) (L × W × H) were dipped in an E. coli O157:H7 broth suspension containing >8 log10 CFU ml(-1) and were drained for 3 min over a sterile cloth, the CMC and NCMC films without SNG were not antimicrobial against E. coli O157:H7; however, NCMC and CMC films with SNG were highly antimicrobial.
* After 5 days at 8°C, E. coli O157:H7 was reduced more than 4 log10 by the NCMC•pSNG film.
* The reduction remained almost the same until 18 days at 8°C when E. coli O157:H7 was reduced >5 log10 CFU g(-1) meat.
The findings strongly support the use of sinigrin for food storage against bacteria.
Taken altogether, sinigrin a bioactive ingredient in cruciferous vegetables may be considered a functional supplement for the treatment of bacterial infection, pending to the confirmation of large sample size and multicenter human study.
However, intake of bioactive in the form of supplement should be taken with extreme care, as liver toxicity may be induced if overdosed.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Source
(1) Sinigrin and Its Therapeutic Benefits by Anisha Mazumder, Anupma Dwivedi and Jeanetta du Plessis. (Molecules)
Sunday, March 31, 2019
3,3'-Diindolylmethane, the Natural Treatment for Arthritis
Arthritis is a group of diseases associated with the inflammation of the joints. According to the epidemiological studies osteoarthritis (OA) and rheumatoid arthritis (RA) are 2 most common types of arthritis.
According to the information provided by the arthritis foundation, arthritis affects over 54 million people in adults of which diagnosed by doctors. Osteoarthritis is the most prevalent type in the US, affecting 31 million Americans.
Depending on types and the location affected, arthritis can be classified into over 100 conditions, but the most common types of arthritis include
* Osteoporosis is a condition of thinning of bone and bone tissues as a result of the loss of bone density over a long period of time.
* Osteoarthritis (OA), is a condition caused by the wear and tear on a joint due to aging, affecting over 25 million people in the United States alone.
* Rheumatoid Arthritis is a chronic disorder as a result of inflammation, affecting mostly the flexible (synovial) joints and tissues and organs in the body.
* Polymyalgia arthritis is a condition of inflammatory rheumatic disease induced pain, stiffness, and tenderness in large muscles, including muscles shoulders and pelvic girdle.
* Fibromyalgia in the newly proposed criteria for the classification of fibromyalgia are 1) widespread pain in combination with 2) tenderness at 11 or more of the 18 specific tender point sites(a) as a result in responding to pressure.
As of today, there is no cure for arthritis, medications used in conventional medicine are to reduce pain, and symptoms and improve quality of life for patients to carry out daily activity.
3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.
In the urgency to discover a natural compound for the treatment of diseases associated with osteoclastogenesis, researchers investigated the therapeutic efficacies of DIM on experimental arthritis.
The study included a rat model of adjuvant-induced arthritis (AIA), with daily AIA paw swelling.
According to the clinical and histologic indices of inflammation and tissue damage, administration of DIM attenuated AIA in animal models.
Furthermore, DIM also reduced the expression of several inflammatory cytokines, associated with the onset of arthritis. However, the anti-inflammatory function of DIM could not prevent the development of arthritis.
Moreover, in the differentiation of the DIM effect on activation-induced cytokine, researchers found that the bioactive compound effectively inhibits the expression of RANKL, leading to the blockade of osteoclastogenesis and consequently an alleviation of experimental arthritis.
Where Receptor activator of nuclear factor kappa-Β ligand (RANKL) is a protein involved the activation-induced cytokine, osteoprotegerin ligand, and osteoclast differentiation factor.
Dr. the lead researcher wrote, "DIM has shown anti-arthritis activity in animal models via inhibiting the expression of RANKL, and thus may offer potential treatments for arthritis and associated disorders".
Taken altogether, 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered a supplement for the prevention and treatment of arthritis, pending to the confirmation of the larger sample size and multicenter human study.
Intake of 3,3'-diindolylmethane in form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) 3,3'-Diindolylmethane increases bone mass by suppressing osteoclastic bone resorption in mice by Yu TY1, Pang WJ2, Yang GS. (PubMed)
(2) 3,3'-Diindolylmethane attenuates experimental arthritis and osteoclastogenesis by Dong L1, Xia S, Gao F, Zhang D, Chen J, Zhang J. (PubMed)
According to the information provided by the arthritis foundation, arthritis affects over 54 million people in adults of which diagnosed by doctors. Osteoarthritis is the most prevalent type in the US, affecting 31 million Americans.
Depending on types and the location affected, arthritis can be classified into over 100 conditions, but the most common types of arthritis include
* Osteoporosis is a condition of thinning of bone and bone tissues as a result of the loss of bone density over a long period of time.
* Osteoarthritis (OA), is a condition caused by the wear and tear on a joint due to aging, affecting over 25 million people in the United States alone.
* Rheumatoid Arthritis is a chronic disorder as a result of inflammation, affecting mostly the flexible (synovial) joints and tissues and organs in the body.
* Polymyalgia arthritis is a condition of inflammatory rheumatic disease induced pain, stiffness, and tenderness in large muscles, including muscles shoulders and pelvic girdle.
* Fibromyalgia in the newly proposed criteria for the classification of fibromyalgia are 1) widespread pain in combination with 2) tenderness at 11 or more of the 18 specific tender point sites(a) as a result in responding to pressure.
As of today, there is no cure for arthritis, medications used in conventional medicine are to reduce pain, and symptoms and improve quality of life for patients to carry out daily activity.
3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.
In the urgency to discover a natural compound for the treatment of diseases associated with osteoclastogenesis, researchers investigated the therapeutic efficacies of DIM on experimental arthritis.
The study included a rat model of adjuvant-induced arthritis (AIA), with daily AIA paw swelling.
According to the clinical and histologic indices of inflammation and tissue damage, administration of DIM attenuated AIA in animal models.
Furthermore, DIM also reduced the expression of several inflammatory cytokines, associated with the onset of arthritis. However, the anti-inflammatory function of DIM could not prevent the development of arthritis.
Moreover, in the differentiation of the DIM effect on activation-induced cytokine, researchers found that the bioactive compound effectively inhibits the expression of RANKL, leading to the blockade of osteoclastogenesis and consequently an alleviation of experimental arthritis.
Where Receptor activator of nuclear factor kappa-Β ligand (RANKL) is a protein involved the activation-induced cytokine, osteoprotegerin ligand, and osteoclast differentiation factor.
Dr. the lead researcher wrote, "DIM has shown anti-arthritis activity in animal models via inhibiting the expression of RANKL, and thus may offer potential treatments for arthritis and associated disorders".
Taken altogether, 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered a supplement for the prevention and treatment of arthritis, pending to the confirmation of the larger sample size and multicenter human study.
Intake of 3,3'-diindolylmethane in form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) 3,3'-Diindolylmethane increases bone mass by suppressing osteoclastic bone resorption in mice by Yu TY1, Pang WJ2, Yang GS. (PubMed)
(2) 3,3'-Diindolylmethane attenuates experimental arthritis and osteoclastogenesis by Dong L1, Xia S, Gao F, Zhang D, Chen J, Zhang J. (PubMed)
Saturday, March 30, 2019
Phytochemical Piperine, the Anti Metabolic Dysfunctions in Obese Patients
Piperine may be considered a natural ingredient for the treatment of metabolic dysfunction in obese patients, some scientists suggested.
Piperine is a phytochemical alkaloid in the class of organosulfur compound, found abundantly in white and black pepper, long pepper, etc.
Obesity is a medical condition characterized by excess body fat accumulated in the body over time.
While overweight is a condition of excess body weight relative to the height.
According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered overweight, while a BMI of over 30 is an indication of obesity. According to the statistic, 68% of the American population is either overweight or obese, a leading cause of metabolic dysfunction.
In other words, obesity is a metabolic disorder that predisposes patients to numerous diseases which not only cause a financial burden to the health care system but also increase the reduction of quality of life of the patients.
A metabolic dysfunction is caused either by the abnormal chemical reactions or disruption of chemical production in the body, altering the normal metabolic process.
Some researchers suggested that obesity's metabolic dysfunction may be a result of the liver or pancreas do not function properly due to fat accumulated in the organs.
There is no coincidence that the widespread of obesity over the past several decades are correlated to the promotion of the Western diet. Some researchers firmly suggested that diet rich in saturated and trans fat, red meat and processed foods and less in fruits and vegetables and whole grain is associated with the onset of obesity.
Dr. Bortolin RC, the lead scientists in the study to examine the metabolic parameters and gut microbiota changes in rat fed with the Western diet suggested: "diet, and not the obese state, was the major driving force behind gut microbiota changes" and "WD-fed rats developed obesity and obesity-related comorbidities independent of major alterations in gut microbiota composition (dysbiosis), whereas CAF-fed rats developed the greatest dysbiosis independent of obesity".
The result clearly stated that long-term intake of the Western diet induces metabolic syndrome and obesity. In other words, Obesity is not the cause of metabolic dysfunction.
On finding a natural ingredient or whole food for the prevention and treatment of widespread obesity-induced metabolic dysfunctions in the Western world, researchers examine the antimetabolic phytochemical Piperine isolated from the black pepper.
The randomized, double-blind, placebo-controlled, 8-week trial included the assessment of the efficacy of metabolic changes versus a placebo.
In a total of 86 overweight subjects selected to the study, 41 patients (2/14 F/M; age 43.7 ± 8.5; BMI 30.3 ± 3.5 kg/m(2)) were assigned to the supplemented group and 45 (29/16; age 40.7 ± 10.2; BMI 30.0 ± 2.7) to the control group.
At the end of 8 weeks, the supplement group showed a decrease of levels of a hormone produced by adipose cells that regulates energy balance by inhibiting hunger. High levels of leptin hormone is an indication of leptin resistance, found in overweight and obese patients.
The levels of a hormone associated with the stimulated appetite increased food intake and promoted fat storage also decreased in the supplement group. Hormone ghrelin is found abundantly in overweight and obese subjects.
Furthermore, the supplement group also showed a decrease of inflammation observed by the levels of C-reactive protein and an increased resting energy expenditure significantly, compared to placebo.
Compared to the decreased significantly levels of adiponectin in the placebo, the supplement group also showed an increase in the hormone protein that regulates glucose levels as well as fatty acid breakdown.
These results suggested that the supplement group demonstrates a greater change of metabolic dysfunction compared to the placebo.
In other words, introducing piperine into the overweight and obese diet might be useful for the treatment of obesity-related inflammatory metabolic dysfunctions.
Additionally, in order to understand the effect of piperine on overweight and obese insulin resistance, researchers evaluated the bioactive chemical activity in mice feeding a high-fat diet (HFD) for 13 weeks.
Before injecting the mice with piperine, researchers found that mice fed with high-fat-diet display elevated plasma concentrations of insulin and glucose and hepatic lipid levels.
Administration of piperine (50 mg/kg body weight) only normalized the concentrations of insulin and glucose and hepatic lipid levels but also increased the levels of adiponectin and inhibited the protein which plays an important role in mediating lipogenesis, fatty acid oxidation and insulin signaling in the livers of mice.
In gene observation, piperine injection also increased the expression of carnitine palmitoyltransferase 1 (CPT1) gene involved the regulation of fatty acid oxidation in the liver, an indication of resist weight gain.
Dr. Choi S, the lead researcher suggested, piperine significantly decreased insulin resistance in mice fed with high-fat diet by increasing the levels of adiponectin and activating the pathway associated with fatty acid oxidation.
Taken altogether, piperine may be considered a bioactive compound for the protection of overweight and obese against the inflammatory and metabolic dysfunctions and weight gain without inducing any side effects
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Improvement in insulin resistance and favourable changes in plasma inflammatory adipokines after weight loss associated with two months' consumption of a combination of bioactive food ingredients in overweight subjects by Rondanelli M, Opizzi A, Perna S, Faliva M, Solerte SB, Fioravanti M, Klersy C, Cava E, Paolini M, Scavone L, Ceccarelli P, Castellaneta E, Savina C, Donini LM. (PubMed)
(2) Piperine reverses high fat diet-induced hepatic steatosis and insulin resistance in mice by Choi S, Choi Y, Choi Y, Kim S, Jang J, Park T.(PubMed)
(3) Piperine, an active principle from Piper nigrum, modulates hormonal and apolipoprotein profiles in hyperlipidemic rats by Vijayakumar RS, Nalini N.(PubMed)(4) A new animal diet based on human Western diet is a robust diet-induced obesity model: comparison to high-fat and cafeteria diets in term of metabolic and gut microbiota disruption by Bortolin RC1, Vargas AR1, Gasparotto J1, Chaves PR1, Schnorr CE1, Martinello KB2, Silveira AK1, Rabelo TK3, Gelain DP1, Moreira JCF. (PubMed)
Ginger, The Potent Anti Obesity Functional Food
Ginger may be considered a functional food for the prevention and treatment of obesity without inducing side effects, some scientists found.
Obesity is a medical disease associated with extreme overweight.
In other words, obesity is the accumulation of excess fat to the extent that it may have an adverse effect on patient health.
According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered overweight, and a BMI of over 30 is an indication of obesity.
According to the statistic, 68% of the American population is either overweight or obese.
What causes obesity? Some researchers suggested that too much calories consumption and lack of physical exercise are the 2 main causes of obesity in once healthy individuals.
Some scientists indicated, there is no coincidence but a close correlation between the onset of obesity in a large percentage of American and the promotion of the Western diet in the past few decades.
Dr. Bortolin RC, the lead researcher in the obese team in the joint study led by the Instituto de Ciências Básicas da Saúde-Universidade Federal do Rio Grande do Sul (UFRGS in the examine the new animal diet based on human Western diet said, "Obesity is a metabolic disorder that predisposes patients to numerous diseases and has become a major global public health concern".
And, " diet, and not the obese state, was the major driving force behind gut microbiota changes. Moreover, the marked dysbiosis observed in CAF-fed rats might have resulted from the presence of several additives present in the CAF diet, or even a lack of essential vitamins and minerals".
These results strongly suggested that the Western diet alters the gut microbiota composition (dysbiosis) probably due to substances found in the Western diet foods, that are not found in other diets, compared to the group treated with HFD developed the greatest dysbiosis independent of obesity
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
On finding natural ingredients or whole food for the treatment of obesity researchers examine the traditional use of ginger in an animal model.
Application of ginger in vivo and vitro demonstrated a potential anti-obesity effect in regulating the PPARγ signaling pathway in adipocytes in the initiation of obesity,
Diet-induced obesity was attenuated in C57BL/6J mice treated with dietary ginger extract (GE)also exhibited an increase in energy expenditure.
GE also exerted an anti-obesity effect through promoting the increased the number of Types I muscle fibers, running endurance capacity and upregulated PPARδ-targeted gene expression in skeletal muscle
Furthermore, the cellular respiration assay also revealed that pretreating cultured skeletal muscle myotubes with GE increased palmitate-induced oxygen consumption rate, which suggested an increase in cellular fatty acid catabolism, another anti-obesity activity.
After taking into account co and confounders, researchers said, "6-Shogaol and 6-gingerol (the ginger bioactive constituents)may be responsible for the regulatory effects of dietary ginger on PPARδ signaling".
Moreover, additional investigation of ginger exerts protective on obesity and its complications, researchers at the showed that gingerenone A, a bioactive compound isolated from ginger had the most potent inhibitory effect on adipogenesis and lipid accumulation in 3T3-L1 cells among ginger components at a single concentration (40 μM).
In vitro data, GA attenuates diet-induced obesity (DIO) by reducing fat mass in mice, accompanied by a modulation of fatty acid metabolism via activation of AMP-activated protein kinase (AMPK) in stimulating weight loss, in vitro and in vivo.
Dr.Suk S the lead authors said at the final report, " GA may be used as a potential therapeutic candidate for the treatment of obesity and its complications by suppressing adipose expansion and inflammation".
Taken altogether, ginger processed abundant bioactive compounds may be considered a functional food in stimulating weight loss in the obese subjects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) Beneficial effects of ginger Zingiber officinale Roscoe on obesity and metabolic syndrome: a review by Wang J1,2, Ke W1, Bao R1, Hu X1,2, Chen F. (PubMed)
(2) Ginger extract prevents high-fat diet-induced obesity in mice via activation of the peroxisome proliferator-activated receptor δ pathway by Misawa K1, Hashizume K2, Yamamoto M3, Minegishi Y4, Hase T5, Shimotoyodome A. (PubMed)
(3) Gingerenone A, a polyphenol present in ginger, suppresses obesity and adipose tissue inflammation in high-fat diet-fed mice by Suk S1, Kwon GT2, Lee E1, Jang WJ1, Yang H1, Kim JH3, Thimmegowda NR4, Chung MY1, Kwon JY5, Yang S1, Kim JK1,5, Park JHY2,3, Lee KW. (PubMed)
(4) A new animal diet based on human Western diet is a robust diet-induced obesity model: comparison to high-fat and cafeteria diets in term of metabolic and gut microbiota disruption by Bortolin RC1, Vargas AR1, Gasparotto J1, Chaves PR1, Schnorr CE1, Martinello KB2, Silveira AK1, Rabelo TK3, Gelain DP1, Moreira JCF. (PubMed)
Obesity is a medical disease associated with extreme overweight.
In other words, obesity is the accumulation of excess fat to the extent that it may have an adverse effect on patient health.
According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered overweight, and a BMI of over 30 is an indication of obesity.
According to the statistic, 68% of the American population is either overweight or obese.
What causes obesity? Some researchers suggested that too much calories consumption and lack of physical exercise are the 2 main causes of obesity in once healthy individuals.
Some scientists indicated, there is no coincidence but a close correlation between the onset of obesity in a large percentage of American and the promotion of the Western diet in the past few decades.
Dr. Bortolin RC, the lead researcher in the obese team in the joint study led by the Instituto de Ciências Básicas da Saúde-Universidade Federal do Rio Grande do Sul (UFRGS in the examine the new animal diet based on human Western diet said, "Obesity is a metabolic disorder that predisposes patients to numerous diseases and has become a major global public health concern".
And, " diet, and not the obese state, was the major driving force behind gut microbiota changes. Moreover, the marked dysbiosis observed in CAF-fed rats might have resulted from the presence of several additives present in the CAF diet, or even a lack of essential vitamins and minerals".
These results strongly suggested that the Western diet alters the gut microbiota composition (dysbiosis) probably due to substances found in the Western diet foods, that are not found in other diets, compared to the group treated with HFD developed the greatest dysbiosis independent of obesity
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
On finding natural ingredients or whole food for the treatment of obesity researchers examine the traditional use of ginger in an animal model.
Application of ginger in vivo and vitro demonstrated a potential anti-obesity effect in regulating the PPARγ signaling pathway in adipocytes in the initiation of obesity,
Diet-induced obesity was attenuated in C57BL/6J mice treated with dietary ginger extract (GE)also exhibited an increase in energy expenditure.
GE also exerted an anti-obesity effect through promoting the increased the number of Types I muscle fibers, running endurance capacity and upregulated PPARδ-targeted gene expression in skeletal muscle
Furthermore, the cellular respiration assay also revealed that pretreating cultured skeletal muscle myotubes with GE increased palmitate-induced oxygen consumption rate, which suggested an increase in cellular fatty acid catabolism, another anti-obesity activity.
After taking into account co and confounders, researchers said, "6-Shogaol and 6-gingerol (the ginger bioactive constituents)may be responsible for the regulatory effects of dietary ginger on PPARδ signaling".
Moreover, additional investigation of ginger exerts protective on obesity and its complications, researchers at the showed that gingerenone A, a bioactive compound isolated from ginger had the most potent inhibitory effect on adipogenesis and lipid accumulation in 3T3-L1 cells among ginger components at a single concentration (40 μM).
In vitro data, GA attenuates diet-induced obesity (DIO) by reducing fat mass in mice, accompanied by a modulation of fatty acid metabolism via activation of AMP-activated protein kinase (AMPK) in stimulating weight loss, in vitro and in vivo.
Dr.Suk S the lead authors said at the final report, " GA may be used as a potential therapeutic candidate for the treatment of obesity and its complications by suppressing adipose expansion and inflammation".
Taken altogether, ginger processed abundant bioactive compounds may be considered a functional food in stimulating weight loss in the obese subjects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) Beneficial effects of ginger Zingiber officinale Roscoe on obesity and metabolic syndrome: a review by Wang J1,2, Ke W1, Bao R1, Hu X1,2, Chen F. (PubMed)
(2) Ginger extract prevents high-fat diet-induced obesity in mice via activation of the peroxisome proliferator-activated receptor δ pathway by Misawa K1, Hashizume K2, Yamamoto M3, Minegishi Y4, Hase T5, Shimotoyodome A. (PubMed)
(3) Gingerenone A, a polyphenol present in ginger, suppresses obesity and adipose tissue inflammation in high-fat diet-fed mice by Suk S1, Kwon GT2, Lee E1, Jang WJ1, Yang H1, Kim JH3, Thimmegowda NR4, Chung MY1, Kwon JY5, Yang S1, Kim JK1,5, Park JHY2,3, Lee KW. (PubMed)
(4) A new animal diet based on human Western diet is a robust diet-induced obesity model: comparison to high-fat and cafeteria diets in term of metabolic and gut microbiota disruption by Bortolin RC1, Vargas AR1, Gasparotto J1, Chaves PR1, Schnorr CE1, Martinello KB2, Silveira AK1, Rabelo TK3, Gelain DP1, Moreira JCF. (PubMed)
Friday, March 29, 2019
Manuka Honey, the Best Anti-influenza Functional Food
Honey may have a profound effect in reducing the risk and treatment of influenza, some scientists suggested.
Influenza, also known as the flu, is an infectious disease caused by an influenza virus.
There are 3 types of flu influenza: A, B, and C. the influenza virus A and B are considered seasonal flu that causes sniffling, aching, coughing, and running and stuffy nose and fever to over 20% of general population.
Influenza virus types C tends to cause mild upper respiratory infections, similar to those of cold.
Healthy individuals who have influenza are usually recovered within one week.
However, people with immature and weakened immune system such as young children under age 5, adults older than age 65 residents of nursing homes and other long-term care facilities, chronic illnesses, such as asthma, heart disease, kidney disease, liver disease and diabetes are not only associated with the risk of influenza but also increase the risk of influenza deadly complication.
Pregnant women and women up to two weeks postpartum due to change of the immune system and other organs have been found to make a woman more prone to influenza and influenza complications.
Some researchers also suggested that obese people are also at a higher risk of the onset of influenza.
Dr. Green WD, the lead author at the University of North Carolina at Chapel Hill suggested that obese individual associated with the impairment of the adaptive immune response at substantial risk of influenza.
The doctor team in the study " Obesity Impairs the Adaptive Immune Response to Influenza Virus" wrote, "Given the dramatic rise in obesity over the past few decades, this increased risk for influenza infection poses a serious public health threat because nearly 500 million adults and children worldwide are classified as obese".
"Obesity impairs the immune response to influenza and influenza vaccination through alterations of the cellular immune system. Compared with vaccinated healthy-weight adults, vaccinated obese adults have twice the risk of influenza or influenza-like illness despite equal serological response to vaccination".
Most common symptoms of influenza are high fever, runny nose, sore throat, muscle pains, headache, coughing, sneezing, and persistent fatigue.
Honey is the miraculous product made by bees using nectar from flowers.
The rich golden liquid It is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.
On finding a natural ingredient and whole food for the prevention and treatment of influenza, researchers at the joint study led by the Nagasaki University the antiviral activities of honey samples were evaluated using MDCK cells.
Application of Manuka honey efficiently inhibited influenza virus replication which is related to its virucidal effects.
Manuka honey at the dose of 3.13 mg/mL also improved the function of zanamivir or oseltamivir by reducing the maximum concentration of effectiveness to nearly 1/1000th for their single use.
Dr.Watanabe K, the lead scientist said, "honey, in general, and particularly Manuka honey, has potent inhibitory activity against the influenza virus, demonstrating a potential medicinal value.
Moreover, by the re-examining the anti-influenza effect of Luatang honey, researchers suspected that the efficacy may be associated with the presence of the methylglyoxal (MGO), a key component of Manuka honey.
By evaluating the anti-influenza viral activity of MGO and its potential in combination treatments with neuraminidase (NA) inhibitors, researchers found that
* Injection of MGO inhibited influenza virus A/WSN/33 replication 50% inhibitory concentration = 240 ± 190 μM; 50% cytotoxic concentration = 1.4 ± 0.4 mM; selective index (SI) = 5.8, which is related to its virucidal effects.
* MGO exerted a promising activity against various influenza strains.
* MGO increases the effect of NA inhibitors by decreasing the to the ∼1/100(th) of their single usage.
* MGO also demonstrates a synergistic effect with NA inhibitor against the oseltamivir-resistant virus.
Taken altogether, Luatang honey processed bioactive compound methylglyoxal (MGO) may be considered a functional food for the prevention and combined with primary therapy for the treatment of influenza with no side effects, pending to a larger and multi=centers human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) Anti-influenza viral effects of honey in vitro: potent high activity of manuka honey by Watanabe K1, Rahmasari R1, Matsunaga A1, Haruyama T2, Kobayashi N3.(PubMed)
(2) In vitro evaluation of synergistic inhibitory effects of neuraminidase inhibitors and methylglyoxal against influenza virus infection by Charyasriwong S1, Watanabe K1, Rahmasari R1, Matsunaga A1, Haruyama T2, Kobayashi N3. (PubMed)
(3) Obesity Impairs the Adaptive Immune Response to Influenza Virus by Green WD1, Beck MA. (PubMed).
Influenza, also known as the flu, is an infectious disease caused by an influenza virus.
There are 3 types of flu influenza: A, B, and C. the influenza virus A and B are considered seasonal flu that causes sniffling, aching, coughing, and running and stuffy nose and fever to over 20% of general population.
Influenza virus types C tends to cause mild upper respiratory infections, similar to those of cold.
Healthy individuals who have influenza are usually recovered within one week.
However, people with immature and weakened immune system such as young children under age 5, adults older than age 65 residents of nursing homes and other long-term care facilities, chronic illnesses, such as asthma, heart disease, kidney disease, liver disease and diabetes are not only associated with the risk of influenza but also increase the risk of influenza deadly complication.
Pregnant women and women up to two weeks postpartum due to change of the immune system and other organs have been found to make a woman more prone to influenza and influenza complications.
Some researchers also suggested that obese people are also at a higher risk of the onset of influenza.
Dr. Green WD, the lead author at the University of North Carolina at Chapel Hill suggested that obese individual associated with the impairment of the adaptive immune response at substantial risk of influenza.
The doctor team in the study " Obesity Impairs the Adaptive Immune Response to Influenza Virus" wrote, "Given the dramatic rise in obesity over the past few decades, this increased risk for influenza infection poses a serious public health threat because nearly 500 million adults and children worldwide are classified as obese".
"Obesity impairs the immune response to influenza and influenza vaccination through alterations of the cellular immune system. Compared with vaccinated healthy-weight adults, vaccinated obese adults have twice the risk of influenza or influenza-like illness despite equal serological response to vaccination".
Most common symptoms of influenza are high fever, runny nose, sore throat, muscle pains, headache, coughing, sneezing, and persistent fatigue.
Honey is the miraculous product made by bees using nectar from flowers.
The rich golden liquid It is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.
On finding a natural ingredient and whole food for the prevention and treatment of influenza, researchers at the joint study led by the Nagasaki University the antiviral activities of honey samples were evaluated using MDCK cells.
Application of Manuka honey efficiently inhibited influenza virus replication which is related to its virucidal effects.
Manuka honey at the dose of 3.13 mg/mL also improved the function of zanamivir or oseltamivir by reducing the maximum concentration of effectiveness to nearly 1/1000th for their single use.
Dr.Watanabe K, the lead scientist said, "honey, in general, and particularly Manuka honey, has potent inhibitory activity against the influenza virus, demonstrating a potential medicinal value.
Moreover, by the re-examining the anti-influenza effect of Luatang honey, researchers suspected that the efficacy may be associated with the presence of the methylglyoxal (MGO), a key component of Manuka honey.
By evaluating the anti-influenza viral activity of MGO and its potential in combination treatments with neuraminidase (NA) inhibitors, researchers found that
* Injection of MGO inhibited influenza virus A/WSN/33 replication 50% inhibitory concentration = 240 ± 190 μM; 50% cytotoxic concentration = 1.4 ± 0.4 mM; selective index (SI) = 5.8, which is related to its virucidal effects.
* MGO exerted a promising activity against various influenza strains.
* MGO increases the effect of NA inhibitors by decreasing the to the ∼1/100(th) of their single usage.
* MGO also demonstrates a synergistic effect with NA inhibitor against the oseltamivir-resistant virus.
Taken altogether, Luatang honey processed bioactive compound methylglyoxal (MGO) may be considered a functional food for the prevention and combined with primary therapy for the treatment of influenza with no side effects, pending to a larger and multi=centers human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) Anti-influenza viral effects of honey in vitro: potent high activity of manuka honey by Watanabe K1, Rahmasari R1, Matsunaga A1, Haruyama T2, Kobayashi N3.(PubMed)
(2) In vitro evaluation of synergistic inhibitory effects of neuraminidase inhibitors and methylglyoxal against influenza virus infection by Charyasriwong S1, Watanabe K1, Rahmasari R1, Matsunaga A1, Haruyama T2, Kobayashi N3. (PubMed)
(3) Obesity Impairs the Adaptive Immune Response to Influenza Virus by Green WD1, Beck MA. (PubMed).
Bilberry Balances the Gut Microbiota for Optimal Health, According to Studies
Scientists may have found a natural and herbal remedy for the improvement of digestive gut microbiota for health optimization, according to studies.
Gut microbiota, or gastrointestinal microbiota, the complex community of microorganisms in our digestive tracts plays a critical role in a variety of metabolic functions, including produced vitamins, synthesized all essential and nonessential amino acids, and carried out biotransformation of bile.
Gut microbiota protects the intestinal structures and functions by attaching to the gut wall against the entry of pathogenic, enteroinvasive bacteria into the epithelial cells.
In the immune perspective, gut microbiota protects the intestines by alerting the immune response against foreign invasion through specific receptors, leading to an immune system in inducing the proinflammatory cytokines.
However, the imbalance of digestive gut microbiota has been found to induce a number of diseases, syndromes, and functional aberrations, including inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS), and wider systemic manifestations of disease such as obesity, and type 2 diabetes.
Imbalanced gut microbiota is found in obese patients, compared to healthy weight individuals.
Dr. Kyle J. Wolf, the lead scientist in the investigation the link of obesity and gut microbiota, wrote, "
In recent years it has been definitively shown that microbiota in the gastrointestinal tract is altered in obese individuals".
And, "Normal humans and mice have 60% to 80% Firmicutes (which are primarily nonculturable, butyrate-producing Clostridium cluster XIVa) and 20% Bacteroidetes (Cytophaga-Flavobacterium-Bacteroides). However, the obese mouse model (ob/ob) had a 50% reduction in Bacteroidetes and an increase in Firmicutes. A similar decrease in Bacteroidetes and increase in Firmicutes is also seen when C57BL/6 mice are fed a high-fat (HF) diet".
The results in the mice model study strongly linked the Western diet and the risk of imbalanced gut microbiota in facilitating the onset of obesity.
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
Scientists on finding a natural ingredient for the improvement of digestive system functioning in the elderly examined the bilberry anthocyanin extract consumption and healthy aging and the effects on intestinal barrier function and digestive enzyme activity.
In the aging rats selected to the study, injection of medium-dose bilberry anthocyanin at 20 mg per kg bw per day) showed to optimizing the intestinal function.
Analyzing the gut microbiota, consumption of bilberry anthocyanin balanced the levels of bacteria in the intestine by increasing the good bacterias such as Aspergillus oryzae, Lactobacillus, Bacteroides, Clostridiaceae-1, the Bacteroidales-S24-7- and the Lachnospiraceae_NK4A136_group) and decreasing the levels of harmful bacterias, such as Verrucomicrobia and Euryarchaeota.
However. injection of any dose higher than 20 mg per kg displayed the alternation of some intestinally beneficial bacteria in an adverse way.
Furthermore, besides improving the levels of gut microbiota, consumption of bilberry anthocyanin also induced the changes in short-chain fatty acids and the intestinal mucosal barrier, correlatedly.
In other words, the injection of the extract consumption also improved the decreased activity of digestive enzymes in breaking down the proteins into amino acids due to aging.
Dr. Li J, the lead scientist wrote, "Bilberry anthocyanin extract consumption is a potential approach for assisting healthy aging".
Moreover, in order to reveal more information about bilberry gut microbiota effects, researchers compared bilberries and cloudberries, the 2 berries on the.intestinal immune responses and gut microbiota.
Injection of bilberry not only reduced the expression of pro-inflammatory cytokines through immunomodulatory activity but also improved the balance of the gut microbiota compared to cloudberries and control group.
Interestingly, cloudberry inhibited and bilberry exhibited the expression of energy metabolism-related genes in the intestinal mucosa.
Additionally, the microbial profiles of cloudberry-fed mice clustered together associated with small adenoma size compared to bilberry group.
The findings suggested that bilberry consumption demonstrated potential digestive health by attenuating of intestinal inflammation, improving microbial profiles, and exhibiting mucosal energy metabolism.
Taken altogether, bilberry processed a high amount bioactive compound may be considered a functional remedy for optimizing the bodily health by balancing the levels of gut microbiota.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Bilberry anthocyanin extract promotes intestinal barrier function and inhibits digestive enzyme activity by regulating the gut microbiota in aging rats by Li J1, Wu T1, Li N1, Wang X1, Chen G1, Lyu X. (PubMed)
(2) Changes in intestinal immunity, gut microbiota, and expression of energy metabolism-related genes explain adenoma growth in bilberry and cloudberry-fed ApcMin mice by Päivärinta E1, Niku M2, Maukonen J3, Storvik M4, Heiman-Lindh A5, Saarela M6, Pajari AM7, Mutanen M. (PubMed)
(3) Part 1: The Human Gut Microbiome in Health and Disease by Matthew J. Bull, BSc, Ph.D. and Nigel T. Plummer, Ph.D. (PMC)
(4) Gut Microbiota and Obesity by Kyle J. Wolfa and Robin G. Lorenz. (PMC)
Gut microbiota, or gastrointestinal microbiota, the complex community of microorganisms in our digestive tracts plays a critical role in a variety of metabolic functions, including produced vitamins, synthesized all essential and nonessential amino acids, and carried out biotransformation of bile.
Gut microbiota protects the intestinal structures and functions by attaching to the gut wall against the entry of pathogenic, enteroinvasive bacteria into the epithelial cells.
In the immune perspective, gut microbiota protects the intestines by alerting the immune response against foreign invasion through specific receptors, leading to an immune system in inducing the proinflammatory cytokines.
However, the imbalance of digestive gut microbiota has been found to induce a number of diseases, syndromes, and functional aberrations, including inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS), and wider systemic manifestations of disease such as obesity, and type 2 diabetes.
Imbalanced gut microbiota is found in obese patients, compared to healthy weight individuals.
Dr. Kyle J. Wolf, the lead scientist in the investigation the link of obesity and gut microbiota, wrote, "
In recent years it has been definitively shown that microbiota in the gastrointestinal tract is altered in obese individuals".
And, "Normal humans and mice have 60% to 80% Firmicutes (which are primarily nonculturable, butyrate-producing Clostridium cluster XIVa) and 20% Bacteroidetes (Cytophaga-Flavobacterium-Bacteroides). However, the obese mouse model (ob/ob) had a 50% reduction in Bacteroidetes and an increase in Firmicutes. A similar decrease in Bacteroidetes and increase in Firmicutes is also seen when C57BL/6 mice are fed a high-fat (HF) diet".
The results in the mice model study strongly linked the Western diet and the risk of imbalanced gut microbiota in facilitating the onset of obesity.
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
Scientists on finding a natural ingredient for the improvement of digestive system functioning in the elderly examined the bilberry anthocyanin extract consumption and healthy aging and the effects on intestinal barrier function and digestive enzyme activity.
In the aging rats selected to the study, injection of medium-dose bilberry anthocyanin at 20 mg per kg bw per day) showed to optimizing the intestinal function.
Analyzing the gut microbiota, consumption of bilberry anthocyanin balanced the levels of bacteria in the intestine by increasing the good bacterias such as Aspergillus oryzae, Lactobacillus, Bacteroides, Clostridiaceae-1, the Bacteroidales-S24-7- and the Lachnospiraceae_NK4A136_group) and decreasing the levels of harmful bacterias, such as Verrucomicrobia and Euryarchaeota.
However. injection of any dose higher than 20 mg per kg displayed the alternation of some intestinally beneficial bacteria in an adverse way.
Furthermore, besides improving the levels of gut microbiota, consumption of bilberry anthocyanin also induced the changes in short-chain fatty acids and the intestinal mucosal barrier, correlatedly.
In other words, the injection of the extract consumption also improved the decreased activity of digestive enzymes in breaking down the proteins into amino acids due to aging.
Dr. Li J, the lead scientist wrote, "Bilberry anthocyanin extract consumption is a potential approach for assisting healthy aging".
Moreover, in order to reveal more information about bilberry gut microbiota effects, researchers compared bilberries and cloudberries, the 2 berries on the.intestinal immune responses and gut microbiota.
Injection of bilberry not only reduced the expression of pro-inflammatory cytokines through immunomodulatory activity but also improved the balance of the gut microbiota compared to cloudberries and control group.
Interestingly, cloudberry inhibited and bilberry exhibited the expression of energy metabolism-related genes in the intestinal mucosa.
Additionally, the microbial profiles of cloudberry-fed mice clustered together associated with small adenoma size compared to bilberry group.
The findings suggested that bilberry consumption demonstrated potential digestive health by attenuating of intestinal inflammation, improving microbial profiles, and exhibiting mucosal energy metabolism.
Taken altogether, bilberry processed a high amount bioactive compound may be considered a functional remedy for optimizing the bodily health by balancing the levels of gut microbiota.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Bilberry anthocyanin extract promotes intestinal barrier function and inhibits digestive enzyme activity by regulating the gut microbiota in aging rats by Li J1, Wu T1, Li N1, Wang X1, Chen G1, Lyu X. (PubMed)
(2) Changes in intestinal immunity, gut microbiota, and expression of energy metabolism-related genes explain adenoma growth in bilberry and cloudberry-fed ApcMin mice by Päivärinta E1, Niku M2, Maukonen J3, Storvik M4, Heiman-Lindh A5, Saarela M6, Pajari AM7, Mutanen M. (PubMed)
(3) Part 1: The Human Gut Microbiome in Health and Disease by Matthew J. Bull, BSc, Ph.D. and Nigel T. Plummer, Ph.D. (PMC)
(4) Gut Microbiota and Obesity by Kyle J. Wolfa and Robin G. Lorenz. (PMC)
Wednesday, March 27, 2019
Avocado-Soybean Unsaponifiables (ASUs), A Natural Treatment of Osteoarthritis, with No side Effects, Studies Showed
Avocado may be considered a functional food for the prevention and treatment of osteoarthritis, some scientists suggested.
Avocado is a commercially valuable fruit cultivated in tropical climates throughout the world.
The fruit is a green-skinned, pear-shaped fruit that ripens after harvesting and native to the Caribbean, Mexico, South America, and Central America, belonging to the flowering plant family Lauraceae.
Osteoarthritis is a group of diseases involved progressive denegation of joints, including articular cartilage and subchondral bone.
According to the statistic, osteoarthritis (OA) is the most common joint disorder in the US, affecting over 10% men and 13% in women aged 60 years or older. The disease can also affect the younger population, after a traumatic injury.
.
Epidemiological studies suggested that symptoms progress slowly and contribute to workplace disability and reduced quality of life.
Dr. Hofmann S, the lead scientist in the team of arthritis in the examine the mechanical causes of osteoarthritis in young adults suggested that that certain conditions such as femoroacetabular impingement (a condition in which extra bone grows along one or both of the bones that form the hip joint) are a very common cause of secondary osteoarthritis (OA) in the young adults" and "
It is an important co-factor in the better recognized pre-arthritic deformities such as residual hip dysplasia (RHD), Perthes disease and slipped capital femoral epiphysis (SCFE)".
These results clearly indicated genetic mutation and mechanical deformity are major causes of osteoarthritis in the younger adult besides athletic injury.
Some scientists proposed that the development of femoroacetabular impingement may be a result of a repetitive injury to the proximal femoral physis occurs during a critical period of development.
With an aim to find a natural ingredient for the prevention and treatment of osteoarthritis, a disease associated with the progressive denegation of joints, researchers at the Universities of Exeter and Plymouth assessed the anti-OA of the compounds Avocado/soybean unsaponifiables (ASU) which have shown some promise for OA.
By searching the database of medical literature, researchers found 4 randomized, placebo-controlled, double-blind trials of ASU.satisified the guideline and criteria.
The doses per day in the 4 studies are in the range between 300 mg and with 600 mg.
3 out of 4 studies suggest that ASU is effective for the symptomatic treatment of OA.
Furthermore, the Hôpital Léopold Bellan launched a follow-up study to investigate the efficacy of preparations with avocado-soybean unsaponifiables (ASUs) in osteoarthritis (OA) patients in the hip, included 163 patients, 102 men and 61 women (mean age 63.2 +/- 8.7 years).
Participants in the study are patients with regular painful primary OA of the hip (European League Against Rheumatism 1980 criteria) and a joint space still > or = 1 mm were selected entered a prospective, multicenter, randomized, parallel group, double-blind, placebo-controlled trial of 2 years duration.
ASU treatment group showed a lesser joint space loss compared to the significantly greater loss in the placebo group.
The clinical parameters in the 2 groups did not differ significantly throughout the study.
These results indicated a significant effect of ASU against the progression of joint loss in OA patients.
Dr,. the lead scientists said, "SU significantly reduced the progression of joint space loss as compared with placebo in the subgroup of patients with advanced joint space narrowing".
Taken altogether, avocado-soybean unsaponifiables (ASUs) may have a profound effect in reducing the symptoms and progression of osteoarthritis.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Avocado-soybean unsaponifiables (ASU) for osteoarthritis - a systematic review by Ernst E.(PubMed)
(2) Symptomatic efficacy of avocado-soybean unsaponifiables (ASU) in osteoarthritis (OA) patients: a meta-analysis of randomized controlled trials by Christensen R1, Bartels EM, Astrup A, Bliddal H.(PubMed)
(3) Structural effect of avocado/soybean unsaponifiables on joint space loss in osteoarthritis of the hip by Lequesne M1, Maheu E, Cadet C, Dreiser RL. (PubMed)
(4) Mechanical causes of osteoarthritis in young adults by Hofmann S, Tschauner Ch, Graf R.(PubMed)
(5) The etiology of primary femoroacetabular impingement: genetics or acquired deformity? by Jonathan D. Packer and Marc R. Safran. (PMC)
Avocado is a commercially valuable fruit cultivated in tropical climates throughout the world.
The fruit is a green-skinned, pear-shaped fruit that ripens after harvesting and native to the Caribbean, Mexico, South America, and Central America, belonging to the flowering plant family Lauraceae.
Osteoarthritis is a group of diseases involved progressive denegation of joints, including articular cartilage and subchondral bone.
According to the statistic, osteoarthritis (OA) is the most common joint disorder in the US, affecting over 10% men and 13% in women aged 60 years or older. The disease can also affect the younger population, after a traumatic injury.
.
Epidemiological studies suggested that symptoms progress slowly and contribute to workplace disability and reduced quality of life.
Dr. Hofmann S, the lead scientist in the team of arthritis in the examine the mechanical causes of osteoarthritis in young adults suggested that that certain conditions such as femoroacetabular impingement (a condition in which extra bone grows along one or both of the bones that form the hip joint) are a very common cause of secondary osteoarthritis (OA) in the young adults" and "
It is an important co-factor in the better recognized pre-arthritic deformities such as residual hip dysplasia (RHD), Perthes disease and slipped capital femoral epiphysis (SCFE)".
These results clearly indicated genetic mutation and mechanical deformity are major causes of osteoarthritis in the younger adult besides athletic injury.
Some scientists proposed that the development of femoroacetabular impingement may be a result of a repetitive injury to the proximal femoral physis occurs during a critical period of development.
With an aim to find a natural ingredient for the prevention and treatment of osteoarthritis, a disease associated with the progressive denegation of joints, researchers at the Universities of Exeter and Plymouth assessed the anti-OA of the compounds Avocado/soybean unsaponifiables (ASU) which have shown some promise for OA.
By searching the database of medical literature, researchers found 4 randomized, placebo-controlled, double-blind trials of ASU.satisified the guideline and criteria.
The doses per day in the 4 studies are in the range between 300 mg and with 600 mg.
3 out of 4 studies suggest that ASU is effective for the symptomatic treatment of OA.
Furthermore, the Hôpital Léopold Bellan launched a follow-up study to investigate the efficacy of preparations with avocado-soybean unsaponifiables (ASUs) in osteoarthritis (OA) patients in the hip, included 163 patients, 102 men and 61 women (mean age 63.2 +/- 8.7 years).
Participants in the study are patients with regular painful primary OA of the hip (European League Against Rheumatism 1980 criteria) and a joint space still > or = 1 mm were selected entered a prospective, multicenter, randomized, parallel group, double-blind, placebo-controlled trial of 2 years duration.
ASU treatment group showed a lesser joint space loss compared to the significantly greater loss in the placebo group.
The clinical parameters in the 2 groups did not differ significantly throughout the study.
These results indicated a significant effect of ASU against the progression of joint loss in OA patients.
Dr,. the lead scientists said, "SU significantly reduced the progression of joint space loss as compared with placebo in the subgroup of patients with advanced joint space narrowing".
Taken altogether, avocado-soybean unsaponifiables (ASUs) may have a profound effect in reducing the symptoms and progression of osteoarthritis.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Avocado-soybean unsaponifiables (ASU) for osteoarthritis - a systematic review by Ernst E.(PubMed)
(2) Symptomatic efficacy of avocado-soybean unsaponifiables (ASU) in osteoarthritis (OA) patients: a meta-analysis of randomized controlled trials by Christensen R1, Bartels EM, Astrup A, Bliddal H.(PubMed)
(3) Structural effect of avocado/soybean unsaponifiables on joint space loss in osteoarthritis of the hip by Lequesne M1, Maheu E, Cadet C, Dreiser RL. (PubMed)
(4) Mechanical causes of osteoarthritis in young adults by Hofmann S, Tschauner Ch, Graf R.(PubMed)
(5) The etiology of primary femoroacetabular impingement: genetics or acquired deformity? by Jonathan D. Packer and Marc R. Safran. (PMC)
Phytochemical Sulforaphane (Dithiolthiones) and Breast cancer, According to Studies
Researchers may have found a natural ingredient for the prevention and treatment of breast cancer with no side effects, according to studies.
Breast cancer is a medical condition associated with abnormal cell growth in the breast tissue due to the alternation of cell DNA.
Most cases of the breast cancer (malignant breast neoplasm) start in the cells on the surface of the inner lining of the tissues of the breast either from the milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk.
At the early stage of breast cancer, most patients experience the forming of lumps or modules on the breast or nearby breast tissue.
However, at the later stage, patients may experience symptoms of swelling of all or part of a breast, breast or nipple pain, nipple retraction and large lumps on the breast.
Some invasive breast cancer in this stage can also induce secondary metastasis through the blood and fluids circulation.
According to the statistic, women diagnosed with breast cancer at stage 0 and 1 have the 5 years of the survival rate of 100%. In 2010, over 250,000 new cases of breast cancer were expected to be diagnosed in the U.S. alone and the risk of getting invasive breast cancer during the lifetime of a woman is 1/8.
Therefore self-examination every month may be important to all women who are classified into the higher prevalent risk group.
The causes of breast cancer are unknown. Epidemiological studies suggested that age, gender, race, family history and menstrual, l and reproductive history are some of the prevalent risk factors for breast cancer.
Some researchers suggested that risk breast cancer in women who carry the mutated genes BRCA1 and 2 have 60% for the development of breast cancer before the age of 90.
Dithiolthiones are phytochemicals in the class of Organosulfides, found abundantly in cruciferous vegetables, garden sorrel, horseradish, etc.
With an aim to find a natural ingredient for the treatment of breast cancer, researchers at the University of Michigan evaluated sulforaphane, a natural compound derived from broccoli/broccoli sprouts, efficacy in inhibiting breast cancer stem cells (CSCs) in tumor growth upon cell reimplantation in secondary mice and human breast cancer cell line.
Sulforaphane injection of (1-5 micromol/L) decreased the cancer cells by 65% to 80% in human breast cancer cells and reduced the size and number of primary mammospheres by 8- to 125-fold and 45% to 75% in tested mice, respectively.
Daily injection with 50 mg/kg sulforaphane for 2 weeks reduced breast cancer cell in the human cell line by >50%.
Sulforaphane eliminated breast CSCs in vivo, and in the secondary mice.
Furthermore, by assessing the effect of SFN alone and in combination with a chemotherapeutic agent, gemcitabine, on the proliferative potential of MCF-7 cells, researchers also found that SFN shows cytotoxic effects on MCF-7 cells in a dose- and time-dependent manner via an apoptotic mode of cell death.
A combinational treatment of SFN and gemcitabine on MCF-7 cells resulted in growth inhibition in a synergistic manner with a combination index.
The efficacy of SFN against MCF-7 was attributed to the inhibition associated with the anti-apoptotic and inflammatory gene, in a time-dependent manner, without causing harm to the nearby healthy cells.
Taken altogether, phytochemical sulforaphane may be considered a bioactive compound for the prevention and combined with primary therapy for the treatment of breast cancer.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Sulforaphane, a dietary component of broccoli/broccoli sprouts, inhibits breast cancer stem cells by Li Y1, Zhang T, Korkaya H, Liu S, Lee HF, Newman B, Yu Y, Clouthier SG, Schwartz SJ, Wicha MS, Sun D.(PubMed)
(2) Sulforaphane inhibits growth of human breast cancer cells and augments the therapeutic index of the chemotherapeutic drug, gemcitabine by Hussain A1, Mohsin J, Prabhu SA, Begum S, Nusri Qel-A, Harish G, Javed E, Khan MA, Sharma C.(PubMed)
(3) Sulforaphane controls TPA-induced MMP-9 expression through the NF-κB signaling pathway, but not AP-1, in MCF-7 breast cancer cells by Lee YR1, Noh EM, Han JH, Kim JM, Hwang BM, Kim BS, Lee SH, Jung SH, Youn HJ, Chung EY, Kim JS.(PubMed)
Breast cancer is a medical condition associated with abnormal cell growth in the breast tissue due to the alternation of cell DNA.
Most cases of the breast cancer (malignant breast neoplasm) start in the cells on the surface of the inner lining of the tissues of the breast either from the milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk.
At the early stage of breast cancer, most patients experience the forming of lumps or modules on the breast or nearby breast tissue.
However, at the later stage, patients may experience symptoms of swelling of all or part of a breast, breast or nipple pain, nipple retraction and large lumps on the breast.
Some invasive breast cancer in this stage can also induce secondary metastasis through the blood and fluids circulation.
According to the statistic, women diagnosed with breast cancer at stage 0 and 1 have the 5 years of the survival rate of 100%. In 2010, over 250,000 new cases of breast cancer were expected to be diagnosed in the U.S. alone and the risk of getting invasive breast cancer during the lifetime of a woman is 1/8.
Therefore self-examination every month may be important to all women who are classified into the higher prevalent risk group.
The causes of breast cancer are unknown. Epidemiological studies suggested that age, gender, race, family history and menstrual, l and reproductive history are some of the prevalent risk factors for breast cancer.
Some researchers suggested that risk breast cancer in women who carry the mutated genes BRCA1 and 2 have 60% for the development of breast cancer before the age of 90.
Dithiolthiones are phytochemicals in the class of Organosulfides, found abundantly in cruciferous vegetables, garden sorrel, horseradish, etc.
With an aim to find a natural ingredient for the treatment of breast cancer, researchers at the University of Michigan evaluated sulforaphane, a natural compound derived from broccoli/broccoli sprouts, efficacy in inhibiting breast cancer stem cells (CSCs) in tumor growth upon cell reimplantation in secondary mice and human breast cancer cell line.
Sulforaphane injection of (1-5 micromol/L) decreased the cancer cells by 65% to 80% in human breast cancer cells and reduced the size and number of primary mammospheres by 8- to 125-fold and 45% to 75% in tested mice, respectively.
Daily injection with 50 mg/kg sulforaphane for 2 weeks reduced breast cancer cell in the human cell line by >50%.
Sulforaphane eliminated breast CSCs in vivo, and in the secondary mice.
Furthermore, by assessing the effect of SFN alone and in combination with a chemotherapeutic agent, gemcitabine, on the proliferative potential of MCF-7 cells, researchers also found that SFN shows cytotoxic effects on MCF-7 cells in a dose- and time-dependent manner via an apoptotic mode of cell death.
A combinational treatment of SFN and gemcitabine on MCF-7 cells resulted in growth inhibition in a synergistic manner with a combination index.
The efficacy of SFN against MCF-7 was attributed to the inhibition associated with the anti-apoptotic and inflammatory gene, in a time-dependent manner, without causing harm to the nearby healthy cells.
Taken altogether, phytochemical sulforaphane may be considered a bioactive compound for the prevention and combined with primary therapy for the treatment of breast cancer.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Sulforaphane, a dietary component of broccoli/broccoli sprouts, inhibits breast cancer stem cells by Li Y1, Zhang T, Korkaya H, Liu S, Lee HF, Newman B, Yu Y, Clouthier SG, Schwartz SJ, Wicha MS, Sun D.(PubMed)
(2) Sulforaphane inhibits growth of human breast cancer cells and augments the therapeutic index of the chemotherapeutic drug, gemcitabine by Hussain A1, Mohsin J, Prabhu SA, Begum S, Nusri Qel-A, Harish G, Javed E, Khan MA, Sharma C.(PubMed)
(3) Sulforaphane controls TPA-induced MMP-9 expression through the NF-κB signaling pathway, but not AP-1, in MCF-7 breast cancer cells by Lee YR1, Noh EM, Han JH, Kim JM, Hwang BM, Kim BS, Lee SH, Jung SH, Youn HJ, Chung EY, Kim JS.(PubMed)
Tuesday, March 26, 2019
Phytochemical Indole-3-carbinol, the Potent Anti Prostate Cancer Plant Base Compound
Scientists may have found a bioactive compound isolated from the cruciferous vegetable for the prevention and treatment of prostate cancer with no side effects, according to studies.
Indole-3-carbinol is a phytochemical in the class of Indoles, by the breaking down of the glucosinolate glucobrassicin, found abundantly in cabbage, kale, Brussels sprouts, rutabaga, mustard greens, broccoli, etc.
Prostate cancer is a medical and chronic condition in which the cells of the prostate has become cancerous due to the alternation of the cells DNA.
Most prostate cancers are slow growing and enlarged prostate and prostate cancer may be detected during the Physical (rectum) exams.
Primary prostate cancer normally starts from the cell on the surface of the inner lining of the prostate tissue and gradually spread to the deeper part of the prostate.
At the early stage, patients may not experience any symptoms, However, at the advanced stage, prostate cancer can induce symptoms of blood in the urine, frequent urination and urinary difficulty.
The cancer cells at this stage can also travel a distance away from the prostate to invade other healthy tissue and organ, leading secondary metastasis tumors.
According to the statistic, the 5-year survival rate for local and regional (stage 0 and 1) stages of prostate cancer is nearly 100%.
Therefore, men who are at higher risk of prostate cancer due to family history and increase in age and inherited gene changes should have their prostate gland checked annually.
Believe it or not, more than 80% of prostate cancers are diagnosed in men who are 65 or older.
Dr. Roberto Fabiani, the lead scientist at the University of Perugia suggested that people who follow the Western diet pattern are at increased risk of prostate cancer onset.
According to the results from the review of 12 observational studies included in the meta-analysis which identified a “Healthy pattern” and a “Western pattern”, he said, "The Healthy pattern was not related to PC risk (OR = 0.96; 95% confidence interval (CI): 0.88–1.04) while the Western pattern significantly increased it (OR = 1.34; 95% CI: 1.08–1.65)".
In other words, by a change of diet from high in saturated and trans fat, red meat and processed foods to diet high in fruits and vegetables and whole grain, the risk of prostate cancer can be reversed.
In order to reaffirm the epidemiological evidence which suggested that intake of cruciferous vegetable intake is associated with a reduced risk of prostate cancer, researchers at the Oregon State University, Corvallis assessed the bioactive compound indole-3-carbinol against the onset of prostate cancer.
In vitro and in vivo. application of indole-3-carbinol inhibit prostate cancer by both blocking initiation and suppressing prostate cancer progression. these results were associated with the induction of phases I and II detoxification pathways.
Injection of indole-3-carbinol inhibited the cell signaling pathways associated with cancer cells proliferation and survival.
Recently, indole-3-carbinol derivatives induced cancer cytotoxicity through induction of free radical expression.
In the laboratory, I3C can induce G1 cell-cycle arrest and apoptosis in prostate cancer cells.
Futhermore, I3C and its derivative dimeric product 3,3'-diindolylmethane (DIM) inhibited the genes associated with the control of cell cycle, cell proliferation, signal transduction, and other cellular processes in prostate cancer cell lines.
Dr. Sarkar FH, the lead scientist, wrote in the final report of the experiment, "Because there is no effective treatment strategy for hormone-dependent and, most importantly, hormone-independent and metastatic prostate cancer, our strategies to sensitize prostate cancer cells to a chemotherapeutic agent by I3C and DIM is a novel breakthrough that could be used for devising novel therapies for prostate cancer".
More importantly, Wayne State University School of Medicine, in the study to confirm that a diet rich in fruits and vegetables provides phytochemicals, launched an investigation to examine the anticancer effect of indole-3-carbinol (I3C).
According to the study, I3C inhibits the growth of PC-3 prostate cancer cells
* through the Induction of G1 cell cycle arrest.
* Promoted the expression of regulators associated with cell cycle progression at G1 and S phase and proteins associated with cancer cell apoptosis.
* Inhibited proteins associated with the progression of cell cycle division
* Inhibited protein in the promotion of proteins associated with cancer cell cycle division.
Taken altogether, the plant base Indole-3-carbinol isolated from the cruciferous vegetable may be used for the prevention and treatment of prostate cancer with no side effects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
references
(1) Phytochemicals from cruciferous vegetables, epigenetics, and prostate cancer prevention. by W Watson G1, M Beaver L, E Williams D, H Dashwood R, Ho E.(PubMed)
(2) Indole-3-carbinol and prostate cancer by Sarkar FH1, Li Y. (PubMed)
(3) Indole-3-carbinol (I3C) induced cell growth inhibition, G1 cell cycle arrest and apoptosis in prostate cancer cells by Chinni SR1, Li Y, Upadhyay S, Koppolu PK, Sarkar FH.(PubMed)
(4) Indole-3-carbinol and 3',3'-diindolylmethane modulate androgen's effect on C-C chemokine ligand 2 and monocyte attraction to prostate cancer cells by Kim EK1, Kim YS, Milner JA, Wang TT. (PubMed)
(5) A Western Dietary Pattern Increases Prostate Cancer Risk: A Systematic Review and Meta-Analysis by Roberto Fabiani,1,* Liliana Minelli,2 Gaia Bertarelli,3 and Silvia Bacci. (PMC)
Ginger, the Natural Anti Oxidative Stress Functional Food
Intake one or 2 slices of ginger daily and regularly may have a strong effect in stimulating the production of antioxidant enzymes in the body against the onset of oxidative stress, scientists found.
Oxidative stress is a result of the overexpression of free radicals, compared to the levels of antioxidant in the body.
Free radicals are a highly reactive and unstable atom with the unpaired electron on the outer ring of the molecules, therefore, in order to become stable, they must donate or steal an electron from other stable molecules, leading to the chain activity that can not be stopped until they are paired or inhibited by antioxidants.
There are many factors associated with the production of free radicals, including the food we eat, the medicines we take, the air we breathe and the water we drink.
In other words, free radical can be generated by alcohol, tobacco smoke, pesticides, and air pollutants.
Antioxidants are stable atoms which inhibit oxidation caused by free radicals.
Some researchers suggested the prolonged presence of oxidative stress can cause damage to the cells, proteins, and alteration of DNA, leading to chronic diseases.
Dr. Eiichiro Ichiishi and colleagues in the concern of the effects of oxidative stress on the risks of diseases showed that oxidative stress not only has a strong implication in the development of diseases but also affects the outcome throughout the course of organ transplantation.
Additionally, the team wrote, "Kidney ischemia/reperfusion injury emerges in various clinical settings as a great problem complicating the course and outcome".
"Xeroderma pigmentosum group A (XPA) is a genetic disorder in DNA nucleotide excision repair (NER) with severe neurological disorders, in which oxidative stress and disturbed melatonin metabolism may be involved".
"Renal transplantation has been considered the best therapeutic option for end-stage renal disease,...determine the effect of renal transplantation on the evolution of oxidative DNA status,".
"Cigarette smoking is the most important risk factor for the development or deterioration of Graves' ophthalmopathy. Smoke-induced increased generation of reactive oxygen species may be involved".
These results indicated the important roles of antioxidants which inhibited the oxidative stress before they can cause a wide range of damage to the human body.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
With an aim to find the best possible antioxidative stress natural ingredient or whole food, researchers examined the protective effects of ginger (Zingiber officinale Roscoe) extract on IL-1β-mediated oxidative stress and mitochondrial apoptosis in C28I2 human chondrocytes.
The cells were pretreated with 5 and 25 μg/mL ginger extract for 24 h, followed by incubation with IL-1β (10 ng/mL) for 24 h.
At the and of the study, ginger extract demonstrated a significant effect in the inhibition of IL-1β-induced intracellular reactive oxygen species (ROS) production and lipid peroxidation.
Ginger extract pretreatment also remarkably increased the gene expression of antioxidant enzymes.
The elevated levels of the Bax/Bcl-2 ratio and caspase-3 involved cells apoptosis were also normalized by the application of ginger extract.
The finding clearly indicated ginger extract could considerably reduce IL-1β-induced oxidative stress and consequent mitochondrial apoptosis as the major mechanisms of chondrocyte cell death and the efficacy was attributed to its antioxidant activity.
In pulmonary abnormalities tested mice induced by chronic ethanol exposure, researchers evaluated whether ginger extract mitigated pulmonary abnormalities induced by ethanol in rats.
The study included male Wistar rats divided into the control group, the ethanol group, and the ethanol plus ginger extract group.
Ethanol group after six-week of treatment increased the proliferation of lung cells, and induced fibrosis, inflammation, and leukocyte infiltration.
The levels of -hydroxydeoxyguanosine, NADPH oxidase, and oxidized low-density lipoprotein were also found to increase substantially in the ethanol-treated group.
Application of ginger extract normalized such changes by inhibiting the oxidative DNA damage and oxidative stress.
Taken altogether, ginger extract may be considered a natural antioxidative stress ingredient by enhancing the production of antioxidants and protecting the body against inflammation.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(2) Protective Effect of Ginger (Zingiber officinale Roscoe) Extract against Oxidative Stress and Mitochondrial Apoptosis Induced by Interleukin-1β in Cultured Chondrocytes by Hosseinzadeh A1, Bahrampour Juybari K, Fatemi MJ, Kamarul T, Bagheri A, Tekiyehmaroof N, Sharifi AM. (PubMed)
(3) Ginger extract attenuates ethanol-induced pulmonary histological changes and oxidative stress in rats by Shirpoor A1, Gharalari FH2, Rasmi Y3, Heshmati E4. (PubMed)
(4) Oxidative Stress and Diseases: Clinical Trials and Approaches by Eiichiro Ichiishi, 1 , * Xiao-Kang Li, 2 and Eugenio L. Iorio. (PubMed)
Oxidative stress is a result of the overexpression of free radicals, compared to the levels of antioxidant in the body.
Free radicals are a highly reactive and unstable atom with the unpaired electron on the outer ring of the molecules, therefore, in order to become stable, they must donate or steal an electron from other stable molecules, leading to the chain activity that can not be stopped until they are paired or inhibited by antioxidants.
There are many factors associated with the production of free radicals, including the food we eat, the medicines we take, the air we breathe and the water we drink.
In other words, free radical can be generated by alcohol, tobacco smoke, pesticides, and air pollutants.
Antioxidants are stable atoms which inhibit oxidation caused by free radicals.
Some researchers suggested the prolonged presence of oxidative stress can cause damage to the cells, proteins, and alteration of DNA, leading to chronic diseases.
Dr. Eiichiro Ichiishi and colleagues in the concern of the effects of oxidative stress on the risks of diseases showed that oxidative stress not only has a strong implication in the development of diseases but also affects the outcome throughout the course of organ transplantation.
Additionally, the team wrote, "Kidney ischemia/reperfusion injury emerges in various clinical settings as a great problem complicating the course and outcome".
"Xeroderma pigmentosum group A (XPA) is a genetic disorder in DNA nucleotide excision repair (NER) with severe neurological disorders, in which oxidative stress and disturbed melatonin metabolism may be involved".
"Renal transplantation has been considered the best therapeutic option for end-stage renal disease,...determine the effect of renal transplantation on the evolution of oxidative DNA status,".
"Cigarette smoking is the most important risk factor for the development or deterioration of Graves' ophthalmopathy. Smoke-induced increased generation of reactive oxygen species may be involved".
These results indicated the important roles of antioxidants which inhibited the oxidative stress before they can cause a wide range of damage to the human body.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
With an aim to find the best possible antioxidative stress natural ingredient or whole food, researchers examined the protective effects of ginger (Zingiber officinale Roscoe) extract on IL-1β-mediated oxidative stress and mitochondrial apoptosis in C28I2 human chondrocytes.
The cells were pretreated with 5 and 25 μg/mL ginger extract for 24 h, followed by incubation with IL-1β (10 ng/mL) for 24 h.
At the and of the study, ginger extract demonstrated a significant effect in the inhibition of IL-1β-induced intracellular reactive oxygen species (ROS) production and lipid peroxidation.
Ginger extract pretreatment also remarkably increased the gene expression of antioxidant enzymes.
The elevated levels of the Bax/Bcl-2 ratio and caspase-3 involved cells apoptosis were also normalized by the application of ginger extract.
The finding clearly indicated ginger extract could considerably reduce IL-1β-induced oxidative stress and consequent mitochondrial apoptosis as the major mechanisms of chondrocyte cell death and the efficacy was attributed to its antioxidant activity.
In pulmonary abnormalities tested mice induced by chronic ethanol exposure, researchers evaluated whether ginger extract mitigated pulmonary abnormalities induced by ethanol in rats.
The study included male Wistar rats divided into the control group, the ethanol group, and the ethanol plus ginger extract group.
Ethanol group after six-week of treatment increased the proliferation of lung cells, and induced fibrosis, inflammation, and leukocyte infiltration.
The levels of -hydroxydeoxyguanosine, NADPH oxidase, and oxidized low-density lipoprotein were also found to increase substantially in the ethanol-treated group.
Application of ginger extract normalized such changes by inhibiting the oxidative DNA damage and oxidative stress.
Taken altogether, ginger extract may be considered a natural antioxidative stress ingredient by enhancing the production of antioxidants and protecting the body against inflammation.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(2) Protective Effect of Ginger (Zingiber officinale Roscoe) Extract against Oxidative Stress and Mitochondrial Apoptosis Induced by Interleukin-1β in Cultured Chondrocytes by Hosseinzadeh A1, Bahrampour Juybari K, Fatemi MJ, Kamarul T, Bagheri A, Tekiyehmaroof N, Sharifi AM. (PubMed)
(3) Ginger extract attenuates ethanol-induced pulmonary histological changes and oxidative stress in rats by Shirpoor A1, Gharalari FH2, Rasmi Y3, Heshmati E4. (PubMed)
(4) Oxidative Stress and Diseases: Clinical Trials and Approaches by Eiichiro Ichiishi, 1 , * Xiao-Kang Li, 2 and Eugenio L. Iorio. (PubMed)
Monday, March 25, 2019
Phytochemical Piperine, the Bioactive Compound May Process Anti Asthmatic Potency, Scientists Suggest
Scientists may have found a natural compound for the prevention and treatment of asthma with no side effects, according to the studies.
Asthma is a chronic inflammatory disease affecting the airway of the lung with recurring symptoms, such as wheezing, chest tightness, shortness of breath, and coughing.
According to the statistics, in Canada, the number of people with asthma continues to grow. One in 12 people or 8% of the population had asthma in 2009, compared with 1 in 14 (about 20 million, or 7%) in 2001.
Asthma attacks had affected over 53% of people with asthma, compared to 57% in children in 2008.
Signs and symptoms of asthma can be triggered by airborne substances, such as pollen, dust mites, mold spores, pet dander or particles of cockroach waste. Respiratory infections, such as the common cold also be found to be the major contribution of asthma in children.
Although, researchers do not know why? people with the same health conditions in the same family, some are susceptible to the onset of asthma, while others do not. However, researchers do know, family history, race, being obese or obese, having another allergic disease, being a smoker, long-term exposure to smoking and irritable chemicals are at the increased risk of asthma development.
Dr. Mahdi Bijanzadeh, the lead scientist in the summary of " An understanding of the genetic basis of asthma" wrote, in the "Asthma is the most common chronic childhood disease in developed nations and its prevalence has increased in the world over the last 25 years. It is a complex disease with both genetic and environmental risk factors. Asthma is caused by multiple interacting genes, some having a protective effect and others contributing to the disease pathogenesis, with each gene having its own tendency to be influenced by the environment".
These results firmly suggested that people inherited a mutated gene from their parent may also be at a higher risk of the disease.
According to Medscape, the 10 genes (IL1RL1/IL18, TSLP, IL33, SMAD3, HLA-DQ, ORMDL3, IL2RB, SLC22A5, IL13, and RORA), 6 of which were confirmed by EVE investigators (IL1RL1/IL18, TSLP, IL33, SMAD3, HLA-DQ and ORMDL3).{Re9} 10 genes have been identified with strong association with the onset of asthma.
Piperine is a phytochemical alkaloid in the class of organosulfur compound, found abundantly in white and black pepper, long pepper, etc.
On finding a natural bioactive compound or whole food for the treatment of asthma, researchers at the JSS College of Pharmacy, Rocklands, examined the different plant extracts and phytoconstituents with the proven anti-asthmatic property.
Piper Longum L. Extract (20% Piperine) demonstrated a significant effect against human pathogens causing upper respiratory infection namely Haemophilus influenza, Streptococcus pneumonia, Streptococcus pyrogen, and Staphylococcus aureus.
Furthermore, researchers examined the effects of increasing levels of antioxidant in asthmatic patients against continued oxidative stress to determine the hypothesis of boosting the antioxidant defenses of asthma patient that could be beneficial as it may help thwart symptoms of lung disease and asthma.
The results of the experiment are astonishing.
Piper longum extracts at the same concentration of 20% piperine or piperine at 98% concentration, displayed a potent antioxidant activity by Nitric oxide radical inhibition activity method.
Dr. Nilani P, the lead scientist, after taking into account co and confounder, said, "Piper longum extract (20% Piperine),..... and piperine (98%) could be utilized in alternate anti-asthmatic therapy, since they play a vital role in scavenging Nitric oxide which could prevent the bronchial inflammation in asthmatic patients.".
The finding suggested that piperine processed anti-asthmatic property through its antioxidants and antibacterial activity.
Taken altogether, piperine may be considered a bioactive compound for the prevention and combined with the primary therapy for treatment of asthma, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Effect of selected antiasthmatic plant constituents against micro organism causing upper respiratory tract infection by Nilani P, Duraisamy B, Dhamodaran P, Ravichandran S, Elango K.(PubMed)
(2) Invitro antioxidant activity of selected antiasthmatic herbal constituents by Nilani P, Kasthuribai N, Duraisamy B, Dhamodaran P, Ravichandran S, Ilango K, Suresh B.(PubMed)
(3) An understanding of the genetic basis of asthma by Mahdi Bijanzadeh, Padukudru A. Mahesh,* and Nallur B. Ramachandra. (PMC)
(4) Genetics of Asthma. Updated: Aug 05, 2015. Author: Scott T Weiss, MD, MS; Chief Editor: Karl S Roth, MD more...(Medscape)
Asthma is a chronic inflammatory disease affecting the airway of the lung with recurring symptoms, such as wheezing, chest tightness, shortness of breath, and coughing.
According to the statistics, in Canada, the number of people with asthma continues to grow. One in 12 people or 8% of the population had asthma in 2009, compared with 1 in 14 (about 20 million, or 7%) in 2001.
Asthma attacks had affected over 53% of people with asthma, compared to 57% in children in 2008.
Signs and symptoms of asthma can be triggered by airborne substances, such as pollen, dust mites, mold spores, pet dander or particles of cockroach waste. Respiratory infections, such as the common cold also be found to be the major contribution of asthma in children.
Although, researchers do not know why? people with the same health conditions in the same family, some are susceptible to the onset of asthma, while others do not. However, researchers do know, family history, race, being obese or obese, having another allergic disease, being a smoker, long-term exposure to smoking and irritable chemicals are at the increased risk of asthma development.
Dr. Mahdi Bijanzadeh, the lead scientist in the summary of " An understanding of the genetic basis of asthma" wrote, in the "Asthma is the most common chronic childhood disease in developed nations and its prevalence has increased in the world over the last 25 years. It is a complex disease with both genetic and environmental risk factors. Asthma is caused by multiple interacting genes, some having a protective effect and others contributing to the disease pathogenesis, with each gene having its own tendency to be influenced by the environment".
These results firmly suggested that people inherited a mutated gene from their parent may also be at a higher risk of the disease.
According to Medscape, the 10 genes (IL1RL1/IL18, TSLP, IL33, SMAD3, HLA-DQ, ORMDL3, IL2RB, SLC22A5, IL13, and RORA), 6 of which were confirmed by EVE investigators (IL1RL1/IL18, TSLP, IL33, SMAD3, HLA-DQ and ORMDL3).{Re9} 10 genes have been identified with strong association with the onset of asthma.
Piperine is a phytochemical alkaloid in the class of organosulfur compound, found abundantly in white and black pepper, long pepper, etc.
On finding a natural bioactive compound or whole food for the treatment of asthma, researchers at the JSS College of Pharmacy, Rocklands, examined the different plant extracts and phytoconstituents with the proven anti-asthmatic property.
Piper Longum L. Extract (20% Piperine) demonstrated a significant effect against human pathogens causing upper respiratory infection namely Haemophilus influenza, Streptococcus pneumonia, Streptococcus pyrogen, and Staphylococcus aureus.
Furthermore, researchers examined the effects of increasing levels of antioxidant in asthmatic patients against continued oxidative stress to determine the hypothesis of boosting the antioxidant defenses of asthma patient that could be beneficial as it may help thwart symptoms of lung disease and asthma.
The results of the experiment are astonishing.
Piper longum extracts at the same concentration of 20% piperine or piperine at 98% concentration, displayed a potent antioxidant activity by Nitric oxide radical inhibition activity method.
Dr. Nilani P, the lead scientist, after taking into account co and confounder, said, "Piper longum extract (20% Piperine),..... and piperine (98%) could be utilized in alternate anti-asthmatic therapy, since they play a vital role in scavenging Nitric oxide which could prevent the bronchial inflammation in asthmatic patients.".
The finding suggested that piperine processed anti-asthmatic property through its antioxidants and antibacterial activity.
Taken altogether, piperine may be considered a bioactive compound for the prevention and combined with the primary therapy for treatment of asthma, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Effect of selected antiasthmatic plant constituents against micro organism causing upper respiratory tract infection by Nilani P, Duraisamy B, Dhamodaran P, Ravichandran S, Elango K.(PubMed)
(2) Invitro antioxidant activity of selected antiasthmatic herbal constituents by Nilani P, Kasthuribai N, Duraisamy B, Dhamodaran P, Ravichandran S, Ilango K, Suresh B.(PubMed)
(3) An understanding of the genetic basis of asthma by Mahdi Bijanzadeh, Padukudru A. Mahesh,* and Nallur B. Ramachandra. (PMC)
(4) Genetics of Asthma. Updated: Aug 05, 2015. Author: Scott T Weiss, MD, MS; Chief Editor: Karl S Roth, MD more...(Medscape)
Phytochemical Allicin, the Potent Anti Liver Cancer Bioactive Compound, According to Scientists
Scientists may have found a natural compound for the prevention and treatment of liver cancer with no side effects, according to the studies.
Liver cancer is a condition caused by cell growth irregularly in the liver tissue.
Since the organ is a soft tissue with less nerve, most liver cancer patients are diagnosed in the later stage of cancer and do not experience any symptoms in the early stage.
At the advanced stage, liver cancer cells can travel a distance away to infect the healthy cells of other tissue and organs, leading secondary metastasis.
According to the statistic, liver cancer remains the fifth most common malignancy in men and the eighth in women worldwide. In Canada, 2,500 Canadians were diagnosed with liver cancer. The disease caused 1200 death in 2017.
Hepatocellular carcinoma (HCC) is a common form of primary liver cancer.
Besides the most common symptoms associated with all cancers, liver cancer patients may experience symptoms of abdominal swelling, jaundice, and white, chalky stools.
Although aging, gender, ethnicity, other liver diseases, hepatitis viruses, obesity is considered one of the major risk factor associated with the onset of the disease.
Dr. Aleksandrova K, the lead author examined the obesity in the risk of liver cancer, said, "Non-alcoholic fatty liver disease associated with obesity, insulin resistance, and type 2 diabetes is an increasingly recognized trigger for liver cancer in Western populations characterized by low prevalence of established risk factors for liver cancer such as viral hepatitis and hepatotoxin exposure".
And, "Recent evidence has implicated several molecular pathways in obesity-associated liver cancer. These include insulin resistance leading to increased levels of insulin and insulin-like growth factors, chronic inflammation, adipose tissue remodeling, a pro-inflammatory cytokine, and adipokine secretion, and altered gut microbiota".
Allicin is phytochemical containing sulfur in the class of organosulfur compound, found abundantly in onion and garlic.
With an aim to find a natural compound with no side effects for the treatment of hepatocellular carcinoma (HCC) which is the most prevalent type of liver cancer globally and ranks first among the cancer-related mortalities in Taiwan, researchers examined the modes of cell death mechanism induced by allicin, a major phytochemical of crushed garlic, in human hepatoma cells.
Allicin treatment was found to induce autophagic cell death in human HCC Hep G2 (p53(wild-type)) cells.
Furthermore, allicin induced apoptotic cell death through proteins associated with pro apoptosis
Moreover, allicin activates the reactive oxygen species (ROS) overproduction to induce cytotoxicity against the human HCC Hep 3B (p53(mutation)) cells without causing harms to the nearby healthy cells.
The finding strongly suggested that allicin protects the normal through its antioxidant activity without inducing inhibition of the overexpression of free radicals.
Additionally, allicin treatment induced apoptotic cell death through gene (p53) involved cell cycle arrest similar to that of Hep 3B cells.
Dr. Chu YL, the lead scientist after taking into account co and confounders, wrote, "allicin induced cell death in human hepatoma cells through either autophagy or apoptosis".
And, "(allicin) might be a potential novel complementary gene therapeutic agent for the treatment of apoptosis-resistant cancer cells".
Taken altogether, phytochemical allicin may be considered a bioactive compound for the prevention and combined with primary medicine for the treatment of liver cancer.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Allicin induces anti-human liver cancer cells through the p53 gene modulating apoptosis and autophagy by Chu YL, Ho CT, Chung JG, Raghu R, Lo YC, Sheen LY. (PubMed)
(2) Obesity and Liver Cancer by Aleksandrova K1, Stelmach-Mardas M2,3, Schlesinger S. (PubMed)
Liver cancer is a condition caused by cell growth irregularly in the liver tissue.
Since the organ is a soft tissue with less nerve, most liver cancer patients are diagnosed in the later stage of cancer and do not experience any symptoms in the early stage.
At the advanced stage, liver cancer cells can travel a distance away to infect the healthy cells of other tissue and organs, leading secondary metastasis.
According to the statistic, liver cancer remains the fifth most common malignancy in men and the eighth in women worldwide. In Canada, 2,500 Canadians were diagnosed with liver cancer. The disease caused 1200 death in 2017.
Hepatocellular carcinoma (HCC) is a common form of primary liver cancer.
Besides the most common symptoms associated with all cancers, liver cancer patients may experience symptoms of abdominal swelling, jaundice, and white, chalky stools.
Although aging, gender, ethnicity, other liver diseases, hepatitis viruses, obesity is considered one of the major risk factor associated with the onset of the disease.
Dr. Aleksandrova K, the lead author examined the obesity in the risk of liver cancer, said, "Non-alcoholic fatty liver disease associated with obesity, insulin resistance, and type 2 diabetes is an increasingly recognized trigger for liver cancer in Western populations characterized by low prevalence of established risk factors for liver cancer such as viral hepatitis and hepatotoxin exposure".
And, "Recent evidence has implicated several molecular pathways in obesity-associated liver cancer. These include insulin resistance leading to increased levels of insulin and insulin-like growth factors, chronic inflammation, adipose tissue remodeling, a pro-inflammatory cytokine, and adipokine secretion, and altered gut microbiota".
Allicin is phytochemical containing sulfur in the class of organosulfur compound, found abundantly in onion and garlic.
With an aim to find a natural compound with no side effects for the treatment of hepatocellular carcinoma (HCC) which is the most prevalent type of liver cancer globally and ranks first among the cancer-related mortalities in Taiwan, researchers examined the modes of cell death mechanism induced by allicin, a major phytochemical of crushed garlic, in human hepatoma cells.
Allicin treatment was found to induce autophagic cell death in human HCC Hep G2 (p53(wild-type)) cells.
Furthermore, allicin induced apoptotic cell death through proteins associated with pro apoptosis
Moreover, allicin activates the reactive oxygen species (ROS) overproduction to induce cytotoxicity against the human HCC Hep 3B (p53(mutation)) cells without causing harms to the nearby healthy cells.
The finding strongly suggested that allicin protects the normal through its antioxidant activity without inducing inhibition of the overexpression of free radicals.
Additionally, allicin treatment induced apoptotic cell death through gene (p53) involved cell cycle arrest similar to that of Hep 3B cells.
Dr. Chu YL, the lead scientist after taking into account co and confounders, wrote, "allicin induced cell death in human hepatoma cells through either autophagy or apoptosis".
And, "(allicin) might be a potential novel complementary gene therapeutic agent for the treatment of apoptosis-resistant cancer cells".
Taken altogether, phytochemical allicin may be considered a bioactive compound for the prevention and combined with primary medicine for the treatment of liver cancer.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Allicin induces anti-human liver cancer cells through the p53 gene modulating apoptosis and autophagy by Chu YL, Ho CT, Chung JG, Raghu R, Lo YC, Sheen LY. (PubMed)
(2) Obesity and Liver Cancer by Aleksandrova K1, Stelmach-Mardas M2,3, Schlesinger S. (PubMed)
Sunday, March 24, 2019
Manuka Honey, The Anti Antioxidants Functional Sweety
Honey may be the next pharmaceutical target to identify the single ingredient medicine for the treatment of diseases associated with oxidative stress, some scientists suggested.
Oxidative stress is a result of an imbalance of the ratio of free radicals and antioxidants in the body.
Free radicals are highly reactive molecules with an unpaired electron on the outer ring of the atom.
Due to its nature to become stable, free radicals readily to donate or steal an electron from other molecules, leading to the chain of domino's effect that can not be stopped until either the electrons are paired or inhibited by antioxidants.
This chain of reaction is the cause of oxidative stress, a condition is associated with either overexpression of free radicals or depletion of antioxidant enzymes produced by the host organs.
Overexpression of free radicals is known to cause damage in contributing to the etiology many chronic health problems such as cardiovascular and inflammatory disease, cataract, and cancer.
Antioxidants, on the other hand, are stable molecules with a unique function in the inhibition of oxidation.
Dr. V. Lobo, the lead author in the study "Free radicals, antioxidants, and functional foods: Impact on human health" wrote, " A balance between free radicals and antioxidants is necessary for proper physiological function. If free radicals overwhelm the body's ability to regulate them, a condition known as oxidative stress ensues", and
"Free radicals thus adversely alter lipids, proteins, and DNA and trigger a number of human diseases. Hence application of an external source of antioxidants can assist in coping this oxidative stress. Synthetic antioxidants such as butylated hydroxytoluene and butylated hydroxyanisole have recently been reported to be dangerous for human health".
These results suggested that regardless of the causes of the overexpression of free radicals, intake of dietary sources of antioxidants from a supplement, herbs, fruits, and vegetables can be beneficial in restoring the healthy ratio of free radicals and antioxidants and preventing the onset of oxidative stress.
Honey is the miraculous product made by bees using nectar from flowers.
The rich golden liquid It is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.
In order to understand the honey antioxidant activity which has been under intensified study by the science community, a joint study led by the researchers conducted was conducted in an animal model.
Ethanol-induced gastric ulcers in rats were randomly assigned to control, ethanol (ulcer), omeprazole, and manuka honey.
Honey treated rats displayed a clinically significant decrease of the ulcer index by completely protected the mucosa from lesions and preserved gastric mucosal glycoprotein.
Application of manuka honey also decreased gastric mucosal MDA, the marker of oxidative stress and plasma TNF-α, IL-1β, and IL-6 concentrations, the set of proinflammatory cytokines produced by the ethanol injection.
The results were attributed to the manuka honey in stimulating the production of antioxidant enzymes which were suppressed by the injection of ethanol in the tested rats.
The finding suggested that manuka honey exerted a strong antioxidant activity by balancing the ratio of free radicals and antioxidant enzymes in the treatment group.
In other words, manuka honey inhibited the oxidative stress caused by overexpression of free radicals in the initiation of the onset of the ulcer.
Further differentiation to reaffirm the effects of manuka honey in the inhibition of gastric ulcer in the rat model, researchers examined three different concentrations of honey applied to the tested rats.
During the experiment, researchers found that all 3 different concentration display a strong effect in It reducing the mucosal myeloperoxidase activity, lipid peroxidation (MDA), and the inflammatory cytokines (TNF-α, IL-1β, and IL-6) compared to the untreated control group.
In other words, manuka honey protects the rat stomach by inhibiting the overexpression free radical and proinflammatory cytokines in inducing oxidative stress.
Application manuka honey also showed a significant increase in enzymatic (GPx and SOD) and nonenzymatic (GSH) antioxidants which were reduced due to ulcer and levels of the anti-inflammatory cytokine IL-10.
The Flow cytometry assay also indicated that treatment of rats with manuka honey has normalized cell cycle distribution and significantly lowered apoptosis in gastric mucosa.
The information collected strong support the use of manuka honey for the treatment of chronic ulcer and preservation of mucosal glycoproteins.
Dr. Almasaudi SB wrote in the final report, "Its (manuka honey) effects are due to its antioxidant and anti-inflammatory properties that resulted in a significant reduction of the gastric mucosal MDA, TNF-α, IL-1β, and IL-6 and caused an elevation in IL-10 levels.
Taken altogether, there is no doubt that manuka honey high in antioxidants can be considered a functional food for the prevention and combined with the primary medicine for the treatment of diseases associated with oxidative stress.
Natural Medicine for Fattstudyver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) Antioxidant, Anti-inflammatory, and Antiulcer Potential of Manuka Honey against Gastric Ulcer in Rats by Almasaudi SB1, El-Shitany NA2, Abbas AT3, Abdel-dayem UA4, Ali SS5, Al Jaouni SK6, Harakeh S. (PubMed)
(2) Manuka Honey Exerts Antioxidant and Anti-Inflammatory Activities That Promote Healing of Acetic Acid-Induced Gastric Ulcer in Rats by Almasaudi SB1, Abbas AT2, Al-Hindi RR1, El-Shitany NA3, Abdel-Dayem UA4, Ali SS5, Saleh RM6, Al Jaouni SK7, Kamal MA8, Harakeh SM. (PubMed)
(3) Protective effects of Manuka honey on LPS-treated RAW 264.7 macrophages. Part 2: Control of oxidative stress induced damage, increase of antioxidant enzyme activities and attenuation of inflammation by Gasparrini M1, Afrin S1, Forbes-Hernández TY1, Cianciosi D1, Reboredo-Rodriguez P2, Amici A1, Battino M1, Giampieri F3. (PubMed)
(4) The inflammation theory of diseas. The growing realization that chronic inflammation is crucial in many diseases opens new avenues for treatment by Philip Hunter. (PubMed)
Oxidative stress is a result of an imbalance of the ratio of free radicals and antioxidants in the body.
Free radicals are highly reactive molecules with an unpaired electron on the outer ring of the atom.
Due to its nature to become stable, free radicals readily to donate or steal an electron from other molecules, leading to the chain of domino's effect that can not be stopped until either the electrons are paired or inhibited by antioxidants.
This chain of reaction is the cause of oxidative stress, a condition is associated with either overexpression of free radicals or depletion of antioxidant enzymes produced by the host organs.
Overexpression of free radicals is known to cause damage in contributing to the etiology many chronic health problems such as cardiovascular and inflammatory disease, cataract, and cancer.
Antioxidants, on the other hand, are stable molecules with a unique function in the inhibition of oxidation.
Dr. V. Lobo, the lead author in the study "Free radicals, antioxidants, and functional foods: Impact on human health" wrote, " A balance between free radicals and antioxidants is necessary for proper physiological function. If free radicals overwhelm the body's ability to regulate them, a condition known as oxidative stress ensues", and
"Free radicals thus adversely alter lipids, proteins, and DNA and trigger a number of human diseases. Hence application of an external source of antioxidants can assist in coping this oxidative stress. Synthetic antioxidants such as butylated hydroxytoluene and butylated hydroxyanisole have recently been reported to be dangerous for human health".
These results suggested that regardless of the causes of the overexpression of free radicals, intake of dietary sources of antioxidants from a supplement, herbs, fruits, and vegetables can be beneficial in restoring the healthy ratio of free radicals and antioxidants and preventing the onset of oxidative stress.
Honey is the miraculous product made by bees using nectar from flowers.
The rich golden liquid It is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.
In order to understand the honey antioxidant activity which has been under intensified study by the science community, a joint study led by the researchers conducted was conducted in an animal model.
Ethanol-induced gastric ulcers in rats were randomly assigned to control, ethanol (ulcer), omeprazole, and manuka honey.
Honey treated rats displayed a clinically significant decrease of the ulcer index by completely protected the mucosa from lesions and preserved gastric mucosal glycoprotein.
Application of manuka honey also decreased gastric mucosal MDA, the marker of oxidative stress and plasma TNF-α, IL-1β, and IL-6 concentrations, the set of proinflammatory cytokines produced by the ethanol injection.
The results were attributed to the manuka honey in stimulating the production of antioxidant enzymes which were suppressed by the injection of ethanol in the tested rats.
The finding suggested that manuka honey exerted a strong antioxidant activity by balancing the ratio of free radicals and antioxidant enzymes in the treatment group.
In other words, manuka honey inhibited the oxidative stress caused by overexpression of free radicals in the initiation of the onset of the ulcer.
Further differentiation to reaffirm the effects of manuka honey in the inhibition of gastric ulcer in the rat model, researchers examined three different concentrations of honey applied to the tested rats.
During the experiment, researchers found that all 3 different concentration display a strong effect in It reducing the mucosal myeloperoxidase activity, lipid peroxidation (MDA), and the inflammatory cytokines (TNF-α, IL-1β, and IL-6) compared to the untreated control group.
In other words, manuka honey protects the rat stomach by inhibiting the overexpression free radical and proinflammatory cytokines in inducing oxidative stress.
Application manuka honey also showed a significant increase in enzymatic (GPx and SOD) and nonenzymatic (GSH) antioxidants which were reduced due to ulcer and levels of the anti-inflammatory cytokine IL-10.
The Flow cytometry assay also indicated that treatment of rats with manuka honey has normalized cell cycle distribution and significantly lowered apoptosis in gastric mucosa.
The information collected strong support the use of manuka honey for the treatment of chronic ulcer and preservation of mucosal glycoproteins.
Dr. Almasaudi SB wrote in the final report, "Its (manuka honey) effects are due to its antioxidant and anti-inflammatory properties that resulted in a significant reduction of the gastric mucosal MDA, TNF-α, IL-1β, and IL-6 and caused an elevation in IL-10 levels.
Taken altogether, there is no doubt that manuka honey high in antioxidants can be considered a functional food for the prevention and combined with the primary medicine for the treatment of diseases associated with oxidative stress.
Natural Medicine for Fattstudyver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) Antioxidant, Anti-inflammatory, and Antiulcer Potential of Manuka Honey against Gastric Ulcer in Rats by Almasaudi SB1, El-Shitany NA2, Abbas AT3, Abdel-dayem UA4, Ali SS5, Al Jaouni SK6, Harakeh S. (PubMed)
(2) Manuka Honey Exerts Antioxidant and Anti-Inflammatory Activities That Promote Healing of Acetic Acid-Induced Gastric Ulcer in Rats by Almasaudi SB1, Abbas AT2, Al-Hindi RR1, El-Shitany NA3, Abdel-Dayem UA4, Ali SS5, Saleh RM6, Al Jaouni SK7, Kamal MA8, Harakeh SM. (PubMed)
(3) Protective effects of Manuka honey on LPS-treated RAW 264.7 macrophages. Part 2: Control of oxidative stress induced damage, increase of antioxidant enzyme activities and attenuation of inflammation by Gasparrini M1, Afrin S1, Forbes-Hernández TY1, Cianciosi D1, Reboredo-Rodriguez P2, Amici A1, Battino M1, Giampieri F3. (PubMed)
(4) The inflammation theory of diseas. The growing realization that chronic inflammation is crucial in many diseases opens new avenues for treatment by Philip Hunter. (PubMed)
Phytochemical 3,3'-Diindolylmethane, the Potential Anti Colon Cancer Bioactive Compound, According to Researchers
3,3'-Diindolylmethane or DIM may have a profound and positive effect in reducing risk and treatment of colon cancer, according to studies.
Colon cancer is a chronic condition caused by irregular cell growth in the tissue of the colon.
Most cases of colon cancer start in the cells on the surface of the inner lining of the colon tissue. It is one of the most slow-growing cancer that takes years to develop. Therefore, most patients in the early stage of cancer do not experience any symptoms.
However, at the advanced stage, cancer can cause severe rectal bleeding and persistent abdominal pain due to the larger size tumor that has pressed on the nearby nerve cells and blood vessels.
According to the statistics, the risk of CRC increases with age; the median age at diagnosis for colon cancer is 68 in men and 72 in women.
The data of colon provided by CDC showed that every year, 97,000 new cases of colon cancer are diagnosed.
Besides sharing the common symptoms with other types of cancer such as unintended weight loss, loss of appetite, persistent fatigue, and tiredness, patients with colon cancer may also experience symptoms of change of bowel movement, rectal bleeding and persistent abdominal discomforts, such as cramps, gas or pain.
If you experience some of the above symptoms, please make sure you check with your doctor to rule out the possibility.
Although there are many risk factors involved in the onset of colon cancer, some researchers suggested aging may be one of the most prevalent risks.
Donna Myers on the examination of the time that needed for a polyp or growth of tissue in the lining to cancer and the percentage of colon cancer cases in people age 50 or older, said, " By the time colorectal cancer is diagnosed, it has often been growing for several years, first as a non-cancerous polyp and later as cancer. Research indicates that by age 50, one out of four people has polyps".
The results strongly suggested that if you are at the age of 50 and a higher risk of colon cancer, you may want to have a colonoscopy done every 3 years.
3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.
Researchers on finding the natural compounds for the treatment of colon cancer examined the two anti-cancer agents (doxycycline or 3,3'-diindolylmethane) on HCT-116 and HT-29 colon cancer cell lines.
Injection of the 2 compounds resulted in profound changes in the intracellular content of several lncRNAs (by up to 100 times secreted by tumors into the bloodstream.
The results strongly suggested that by examining the levels of lncRNAs colon cancer expression can be monitored through tumor relapse and metastasis.
In order to reveal more information about 3the Sulindac (SU; 320 ppm) effect on colon cancer, researchers examined two natural compounds, 3,3'-diindolylmethane (DIM; 250 ppm) and curcumin (CUR; 2000 ppm), with or without lower doses of SU could affect carcinogenesis.
Colon tumors were significantly reduced by SU 320 ppm (62 % reduction over Controls), by DIM and CUR without or with SU 80 and 160 ppm (50, 53 and 58 % reduction, respectively) but not by SU 80 ppm alone.
Futhermore, total tumors (colon and small intestine) were found to reduce substantially by SU (80 and 320 ppm) and by DIM and CUR.
Apoptosis in the normal mucosa was significantly increased by SU 320 ppm and slightly increased by DIM and CUR with or without SU.
The combination of SU with DIM or Cur also caused a slight reduction in Survivin-Birc5 expression observed with all the treatments compared to controls.
Where Survivin-Birc5 protein is found to inhibit caspases associated with the blocking of cancer cell death. The protein is highly expressed in most cancers associated with a poor clinical outcome.
The results strongly reaffirmed the anti-colon cancer activity of DIM and CUR combination.
Taken altogether, DIM used alone or combined with another bioactive compound may be considered a supplement for the prevention and comn=bined with primary medicine for the treatment of colon cancer, pending to the confirmation of larger sample size and multicenter human study.
Intake of DIM as o form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) [Treatment with anti-cancer agents results in profound changes in lncRNA expression in colon cancer cells].[Article in Russian] by Zinovieva OL1, Grineva EN1, Prokofjeva MM1, Karpov DS1, Krasnov GS1, Prassolov VS1, Mashkova TD1, Lisitsyn NA. (PubMed)
(2) Sulindac, 3,3'-diindolylmethane and curcumin reduce carcinogenesis in the Pirc rat, an Apc-driven model of colon carcinogenesis by Femia AP1, Soares PV2, Luceri C3, Lodovici M4, Giannini A5, Caderni G. (PubMed)
(3) The Link Between Age and Colorectal Cancer Risk by Donna Myers
Subscribe to:
Posts (Atom)