Wednesday, October 31, 2018
Scientists Successfully Found the Vitamins That Suppress Over Growth of Candida, Cited by MEDLINE
Candida albicans are members of a large group of microorganism whose cells contain complex structures enclosed within the membranes, including yeast(2)(3), fungi(4)(5)(6), and mold(6) that live among the gut flora in the human mouth and gastrointestinal tract.
Non-albicans Candida (NAC) species cause 35-65% of all candidaemias in the general patient population(1).
According to joint study, in many cases, biofilm(microorganisms with cells stick to each other on a surface) formation(7) gene mutations(8) and overexpression of genes(9)(10) are often associated with increased candida resistance toward antifungal drugs.
NADPH oxidase (NOX) are enzymes that generate reactive oxygen species by transporting electrons across lipid membranes.to induce cytotoxicity against invading microbes. However, according to the joint study led by Johns Hopkins University Bloomberg School of Public Health, Candida albicans is capable of a ROS burst, using a member of the NOX enzyme family to produce ROS with an aim to drive fungal morphogenesis in the animal host(a).
Vitamin A, B2, C and E as antioxidants and free radical scavengers may have a potential role in inhibited superoxide anion (ROS) radicals caused by overexpression of candida via NADPH oxidase (NOX) enzymes(b).
.
The Anti Over Growth of Candida Vitamins
1. Vitamin B2
Vitamin B2 required for a wide variety of cellular processes plays a key role in energy metabolism and enhances the digestive system in absorbing nutrients and supports the immune system(230)(231) in fighting against bacteria causes of inflammatory disease, including candida(232).
2. Vitamin C
Vitamin C, a water-soluble vitamin and an antioxidant found in high concentrations in immune cells, is not only important in aiding the digestive system in absorbing nutrients, but also enhances the production of white blood cell(233)(234) of the immune system(235) in protection of the body by binding to the harmful bacteria(236) and ingesting them.
3. Vitamin A
Retinoic acid appears to maintain normal skin health by switching on genes and differentiating keratinocytes (immature skin cells)(237) into mature epidermal cells and helps to detox the liver(238).
The vitamin also enhances the immune system(239)(240) in protecting our body through its antimicrobial functions, including Candida albicans(241).
4. Vitamin E
Vitamin E is fat-soluble compounds included both tocopherols and tocotrienols. It not only is a polyphenol antioxidant (242)(246) in scavenging free radicals and microorganisms, but also promotes the immune system in enhanced functions of B-cells(244)(245), the immune cells(245)(247) in the production of antibodies to destroy infectious agents.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
(a) Candida albicans FRE8 encodes a member of the NADPH oxidase family that produces a burst of ROS during fungal morphogenesis by Rossi DCP1, Gleason JE1, Sanchez H2, Schatzman SS1, Culbertson EM1, Johnson CJ2, McNees CA1, Coelho C3, Nett JE2, Andes DR2, Cormack BP4, Culotta VC(PubMed)
(b) Free radical scavenging and antiproliferative properties of Biginelli adducts by da Silva DL1, Reis FS, Muniz DR, Ruiz AL, de Carvalho JE, Sabino AA, Modolo LV, de Fátima A(PubMed)
(1) Non-albicans Candida spp. causing fungaemia: pathogenicity and antifungal resistance by Krcmery V1, Barnes AJ.(PubMed)
(2) Pathogenicity and drug resistance in Candida albicans and other yeastspecies. A review by Mishra NN1, Prasad T, Sharma N, Payasi A, Prasad R, Gupta DK, Singh R.(PubMed)
(3) Multidrug resistance in yeast Candida by Prasad R1, Kapoor K.(PubMerd)
(4) New evidence that Candida albicans possesses additional ATP-binding cassette MDR-like genes: implications for antifungal azole resistance. by Walsh TJ1, Kasai M, Francesconi A, Landsman D, Chanock SJ.(PubMed)
(5) Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters.by Sanglard D1, Kuchler K, Ischer F, Pagani JL, Monod M, Bille J.(PubMed)
(6) Structural analysis of phospho-D-mannan-protein complexes isolated from yeast and mold form cells of Candida albicans NIH A-207 serotype A strain by Shibata N1, Fukasawa S, Kobayashi H, Tojo M, Yonezu T, Ambo A, Ohkubo Y, Suzuki S.(PubMed)
(7) The effect of antifungal combination on transcripts of a subset of drug-resistance genes in clinical isolates of Candida species induced biofilms by Ibrahim NH1, Melake NA2, Somily AM3, Zakaria AS4, Baddour MM5, Mahmoud AZ6(PubMed)
(8) Antifungal drug resistance in pathogenic fungi. by Vanden Bossche H1, Dromer F, Improvisi I, Lozano-Chiu M, Rex JH, Sanglard D.(PubMed)
(9) The genetic basis of fluconazole resistance development in Candida albicans by Morschhäuser J1.(PubMed)
(10) A proteomic approach to understanding the development of multidrug-resistant Candida albicans strains by Kusch H1, Biswas K, Schwanfelder S, Engelmann S, Rogers PD, Hecker M, Morschhäuser J.(PubMed)
(230) Edible mushrooms: improving human health and promoting quality life by Valverde ME1, Hernández-Pérez T1, Paredes-López O1.(PubMed)
(231) [Effect of some vitamins on activity of immunocompetent cells].[Article in Russian]by Nezgovorov DV.(PubMed)
(232) Antioxidants keep the potentially probiotic but highly oxygen-sensitive human gut bacterium Faecalibacterium prausnitzii alive at ambient air by Khan MT1, van Dijl JM1, Harmsen HJ1.(PubMed)
(233) Storing red blood cells with vitamin C and N-acetylcysteine prevents oxidative stress-related lesions: a metabolomics overview by Pallotta V1, Gevi F1, D'alessandro A1, Zolla L1.(PubMed)
(234) Red blood cell metabolism under prolonged anaerobic storage by D'Alessandro A1, Gevi F, Zolla L.(PubMed)
(235) Alterations in antioxidant defense system of workers chronically exposed to arsenic, cadmium and mercury from coal flying ash by Zeneli L1, Sekovanić A, Ajvazi M, Kurti L, Daci N.(PubMed)(236) Indomethacin-induced translocation of bacteria across enteric epithelia is reactive oxygen species-dependent and reduced by vitamin C by Schoultz I1, McKay CM, Graepel R, Phan VC, Wang A, Söderholm J, McKay DM.(PubMed)
(237) Vitamin C derivative ascorbyl palmitate promotes ultraviolet-B-induced lipid peroxidation and cytotoxicity in keratinocytes by Meves A1, Stock SN, Beyerle A, Pittelkow MR, Peus D.(PubMed)
238. Effects of dried fish on antioxidant levels in rat liver by Anilakumar KR1, Khanum F, Krishna KR, Viswanathan KR.(PubMed)
(239) Vitamin A and retinoic acid in T cell-related immunity by Ross AC1.(PubMed)
(240) Vitamin A and immune regulation: role of retinoic acid in gut-associated dendritic cell education, immune protection and tolerance by Cassani B1, Villablanca EJ, De Calisto J, Wang S, Mora JR.(PubMed)(241) Modulatory role of vitamin A on the Candida albicans-induced immune response in human monocytes by Klassert TE1, Hanisch A, Bräuer J, Klaile E, Heyl KA, Mansour MK, Tam JM, Vyas JM, Slevogt H.(PubMed)
(242) [Toxicology of the synthetic antioxidants BHA and BHT in comparison with the natural antioxidant vitamin E].[Article in German]by Kahl R1, Kappus H.(PubMed)
(243) Effectiveness of antioxidants (vitamin C and E) with and without sunscreens as topical photoprotectants by Darr D1, Dunston S, Faust H, Pinnell S.(PubMed)
(244) Immune dysfunction and cytokine production in hemodialysis. Could they be lessened by vitamin E-coated dialyzer membrane by Senatore M, Cecere P, Colombo P, Costantini L, Filiberti O, Piccini G, Peona C, Buemi M, Nicoletti A, Rizzuto G.(PubMed)
(245) Prospective crossover trial of the influence of vitamin E-coated dialyzer membranes on T-cell activation and cytokine induction by Girndt M1, Lengler S, Kaul H, Sester U, Sester M, Köhler H.(PubMed)
(246) Vitamin E and immunity by Moriguchi S1, Muraga M.(PubMed)
(247) The role of vitamin E in T-cell differentiation and the decrease of cellular immunity with aging.by Moriguchi S1.(PubMed)(249) By the way, doctor. I recently saw a TV ad for a product called "coralcalcium," which is supposed to prevent osteoporosis and other diseases. What do you know about it by Robb-Nicholson C.(PubMed)
Monday, October 29, 2018
The Phytochemicals That Inhibit Kidney Cancer Cells
Lentils' (plant sources') lectin may be considered as biomarkers for detection of the early stage of varies types of cancer and treatment of renal cancer, some scientists suggested.
Lentil, a type of pulse and tiny legume that can be cooked quickly and rich in protein and fiber is a bushy annual plant of genus Lens to the Fabaceae family, native to the Middle East.
Kidney Cancer is a medical condition characterized by irregular cells growth in the tissue of kidneys.
At the later stage, the cancerous cells may travel a distance way to infect other organs' tissues.
For example, if kidney cancer spread to the lung is called kidney cancer with lung metastases.
At the very early stage of the kidney, cancerous tumors that are localized in the surface of the kidneys.
The most common type of kidney cancer is renal cell cancer.
The kidney is of 3 main detoxified organs with the main function of filtering water and waste from your blood.
The causes of the kidney cancer are unknown, but some researcher suggested that genetic mutation, cigarette smoking, obese, family history,..... and exposed to chemicals, such as asbestos and benzene are all associated to increased risk of kidney cancer.
The cancer is only infected approximately 2% of the general population and screening test is only designated for kidney cancer in people who are at higher risk of the disease.
In the UK, The survival rate of early diagnosis of the early stage of kidney cancer is very high with five-year survival rates for renal cancer of 70-94% for localized tumors
According to statistics reported by Dr. Lewis G, the lead author, " Kidney cancers account for 2-3% of all adult malignancies in the UK. Men are predominantly affected by renal cancer with an average age at diagnosis of 64 years. Renal (or clear) cell carcinoma (RCC) accounts for 90% of kidney cancers"(4) and "RCC should be suspected in the presence of localized symptoms such as flank pain, a loin mass or haematuria; constitutional upset including weight loss, pyrexia and/or night sweats; or with unexplained laboratory tests"(4).
Imaging tests such as computed tomography (CT) or magnetic resonance imaging (MRI), are the best to spot cancer in patients who are at high risk and susceptible to kidney cancer.
According to the investigation of plant lectin effect in risk of cancers, by resisting digestion, lectins after intake maintained full biological activity in binding to the cancer cell remembrances or. and receptors to induce cytotoxicity, thus reducing cancer cell proliferation and inhibiting tumor growth.
lectins can also incorporate into cancer cell as an antigen to cause agglutination and/or aggregation in the induction of cytolysis and inhibit expression of polyamines, small organic cations that are essential for cancer cells to grow.
Furthermore, plant lectins altered the production of various interleukins that are essential importance for the function of both innate and adaptive immunity by activated certain protein kinases in regulating signal transduction pathways in control cancer cells process in the induction of tumor progression.
Additionally, lectins can also bind to cancer cell mutated ribosomes, a cell structure that makes protein and inhibits protein synthesis, thus disrupting the critical cellular processes necessary for sustained cancer cell growth and modified the cancer cell phase 1 division and G2/M phase cell cycle arrest.
Interestingly, injection of lectins also inhibited telomerase expression in cancer cell activity in maintaining tumor progression and angiogenesis in the stimulated production of the new blood vessel to provide nutrients and oxygen to cancer cells proliferation and tumor expansion.
In clear-cell renal cell carcinoma (ccRCC), Galectin-9 (Gal-9), an animal lectin injection exerted a significant effect in inhibited cancer cell proliferation through binding to β-galactoside which is important to provide energy to tumor survival.
Further investigation of the expression of Gal-9 in a total of in 196 patients with ccRCC who underwent nephrectomy, with 48/196 patients died and 61/196 patients suffered recurrence to assess the prognostic value of Gal-9, suggested that Gal-9 expression not only associates positively with tumor size but also induces a direct impact in the relative survival ratio, used to predict overall survival (OS) and recurrence-free survival (RFS) of patients.
Indeed, high levels of Gal-9 was found to associate correlated to poor survival and early recurrence and the expression of lectin also can be considered as a biomarker in diagnosed clear-cell renal cell carcinoma (ccRCC) in early stage and lower of grade of tumor, node, and metastasis in patients who are at higher risk of the kidney cancer developing.
The finding evidence suggested that lectins from all sources may be considered as therapeutic substances and biomarkers for treatment and monitoring the progression of kidney cancer.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Lectin reactivity of alpha-fetoprotein in a case of renal cell carcinoma by Taketa K1, Ichikawa E, Sakuda H, Iwamasa T, Hayakawa M, Taga H, Hirai H.(PubMed)
(2) Lectins as bioactive plant proteins: a potential in cancer treatment by De Mejía EG1, Prisecaru VI.(PubMed)
(3) Galectin-9 predicts postoperative recurrence and survival of patients with clear-cell renal cell carcinoma by Fu H1, Liu Y, Xu L, Liu W, Fu Q, Liu H, Zhang W, Xu J.(PubMed)
(4) Early diagnosis improves survival in kidney cancer by Lewis G1, Maxwell AP(PubMed)
The Anti Migraine Diet That Works
A migraine is one most common headaches characterized by chronic neurological disorder of moderate to severe headaches, and nausea that usually develops gradually over 5–20 minutes and lasts for less than 60 minutes.
The condition affects over 15% population in the US, as a result of the change in the brain and its surrounding blood vessels.
Some researchers suggested that dietary and gastrointestinal issues have a significant impact in the clinical expression of a migraine, including gut dysfunction during and between attacks, food triggers, increase in a migraine with obesity, comorbid GI and systemic inflammation influenced by diet, and specific food allergies such as dairy and gluten(1).
And, caregivers and practitioners not only need to encourage migraineurs to seek consistency in their lifestyle behaviors, and environmental exposures, as a way of avoiding sudden changes that may precipitate attacks(1) but also must remind them to avoid suspected foods that trigger, consistently(1).
Believe it or not, according to statistic and research, migraine headaches have caused a substantial individual impact on work productivity and increased a significant societal burden to direct medical costs, lost work time(2).
And in more severe persistent migraine, the lost work time costs greatly exceed medical care costs(2).
Most common symptoms during migraine attacks include pain on one side or both sides of the head and pain that feels throbbing or pulsing.
Some patients during attacks also experience symptoms of light, sounds, smells and touch sensitivity.
In some cases, the attack also induces symptoms of nausea and vomiting. blurred vision..... and lightheadedness.
Diet for a Migraine headache
Certain diet may trigger the attack of a migraine due to an allergic reaction in certain people, but the below-suggested foods may be helpful to people who experience a migraine with no allergic effects.
1. Water
Water, an essential for the body’s proper functioning, and dehydration may trigger the migraine attack.
In a study of 50 migraineurs were asked if insufficient fluid intake could provoke their migraine attacks conducted by The City of London Migraine Clinic, researchers found that twenty replied "yes," 7 were doubtfully positive, and 23 said "no."
In addition of 14 of 45 migraineurs at a meeting of the British Migraine Association (UK) also recognized fluid deprivation as one of their migraine triggers. (E.C.1).
Therefore, adding fluid deprivation to migraine patient may reduce the numbers of migraine attacks.
2. Fish oil
Omega-3 PUFA, from fish oil-eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) process anti-inflammatory properties of which are useful in the management of inflammatory and autoimmune diseases, including rheumatoid arthritis, Crohn's disease, ulcerative colitis, psoriasis, lupus erythematosus, multiple sclerosis, and migraine headaches. (E.C.2)
3. Broccoli
Broccoli is a very good source of magnesium and a good source of calcium.
Magnesium plays an essential in many intracellular processes and in migraine pathogenesis. Low levels of magnesium may promote cortical spreading depression, hyper-aggregation of platelets, affect serotonin receptor function, and influence synthesis and release of a variety of neurotransmitters of which can trigger a migraine headache(B.A.8)
4. Sardines
Sardines contain a measurable amount of Omega 3 fatty acid, calcium, and CoQ10 with function in reduced frequency of a migraine headache (E.B.3)(E.B.2)
5. Spinach
Spinach is an excellent source of both calcium, magnesium, vitamin B2 (riboflavin).
Riboflavin therapy supplemented may be appropriate alternatives in patients with migraine disorder as it significant decreases in headache frequency, intensity, duration and medication intake (E.C.7)
6. Mustard Greens
The World's Healthiest Foods recommends mustard greens as an excellent source of calcium and a very good source of magnesium which is important in preventing and treating migraine headache (See E.B.1 and 2)
7. Fish
Beside rich in Omega 3 fatty acids, all fish contain more or less DL-phenylalanine, an essential amino acid of which is important for our body converts phenylalanine to tyrosine, another amino acid then to epinephrine and norepinephrine, which are important brain chemicals called neurotransmitters.
Some researchers suggest that DL-phenylalanine(DLPA) appears to potentiate pain relief and ease depression in patients receiving opiates for chronic non-malignant pain(E.C.9).
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(E.C.1) http://www.ncbi.nlm.nih.gov/pubmed/15953311
(E.C.2) http://www.ncbi.nlm.nih.gov/pubmed/12480795
(E.C.7) http://www.ncbi.nlm.nih.gov/pubmed/21197315
(E.C.9) http://www.ncbi.nlm.nih.gov/pubmed/10998643
(B.A.8) http://www.ncbi.nlm.nih.gov/pubmed/22426836
(E.B.2) http://www.ncbi.nlm.nih.gov/pubmed/2948651
(E.B.3) http://www.ncbi.nlm.nih.gov/pubmed/17355497
(1) https://www.ncbi.nlm.nih.gov/pubmed/24068338
(2) https://www.ncbi.nlm.nih.gov/pubmed/26563803
The condition affects over 15% population in the US, as a result of the change in the brain and its surrounding blood vessels.
Some researchers suggested that dietary and gastrointestinal issues have a significant impact in the clinical expression of a migraine, including gut dysfunction during and between attacks, food triggers, increase in a migraine with obesity, comorbid GI and systemic inflammation influenced by diet, and specific food allergies such as dairy and gluten(1).
And, caregivers and practitioners not only need to encourage migraineurs to seek consistency in their lifestyle behaviors, and environmental exposures, as a way of avoiding sudden changes that may precipitate attacks(1) but also must remind them to avoid suspected foods that trigger, consistently(1).
Believe it or not, according to statistic and research, migraine headaches have caused a substantial individual impact on work productivity and increased a significant societal burden to direct medical costs, lost work time(2).
And in more severe persistent migraine, the lost work time costs greatly exceed medical care costs(2).
Most common symptoms during migraine attacks include pain on one side or both sides of the head and pain that feels throbbing or pulsing.
Some patients during attacks also experience symptoms of light, sounds, smells and touch sensitivity.
In some cases, the attack also induces symptoms of nausea and vomiting. blurred vision..... and lightheadedness.
Diet for a Migraine headache
Certain diet may trigger the attack of a migraine due to an allergic reaction in certain people, but the below-suggested foods may be helpful to people who experience a migraine with no allergic effects.
1. Water
Water, an essential for the body’s proper functioning, and dehydration may trigger the migraine attack.
In a study of 50 migraineurs were asked if insufficient fluid intake could provoke their migraine attacks conducted by The City of London Migraine Clinic, researchers found that twenty replied "yes," 7 were doubtfully positive, and 23 said "no."
In addition of 14 of 45 migraineurs at a meeting of the British Migraine Association (UK) also recognized fluid deprivation as one of their migraine triggers. (E.C.1).
Therefore, adding fluid deprivation to migraine patient may reduce the numbers of migraine attacks.
2. Fish oil
Omega-3 PUFA, from fish oil-eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) process anti-inflammatory properties of which are useful in the management of inflammatory and autoimmune diseases, including rheumatoid arthritis, Crohn's disease, ulcerative colitis, psoriasis, lupus erythematosus, multiple sclerosis, and migraine headaches. (E.C.2)
3. Broccoli
Broccoli is a very good source of magnesium and a good source of calcium.
Magnesium plays an essential in many intracellular processes and in migraine pathogenesis. Low levels of magnesium may promote cortical spreading depression, hyper-aggregation of platelets, affect serotonin receptor function, and influence synthesis and release of a variety of neurotransmitters of which can trigger a migraine headache(B.A.8)
4. Sardines
Sardines contain a measurable amount of Omega 3 fatty acid, calcium, and CoQ10 with function in reduced frequency of a migraine headache (E.B.3)(E.B.2)
5. Spinach
Spinach is an excellent source of both calcium, magnesium, vitamin B2 (riboflavin).
Riboflavin therapy supplemented may be appropriate alternatives in patients with migraine disorder as it significant decreases in headache frequency, intensity, duration and medication intake (E.C.7)
6. Mustard Greens
The World's Healthiest Foods recommends mustard greens as an excellent source of calcium and a very good source of magnesium which is important in preventing and treating migraine headache (See E.B.1 and 2)
7. Fish
Beside rich in Omega 3 fatty acids, all fish contain more or less DL-phenylalanine, an essential amino acid of which is important for our body converts phenylalanine to tyrosine, another amino acid then to epinephrine and norepinephrine, which are important brain chemicals called neurotransmitters.
Some researchers suggest that DL-phenylalanine(DLPA) appears to potentiate pain relief and ease depression in patients receiving opiates for chronic non-malignant pain(E.C.9).
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(E.C.1) http://www.ncbi.nlm.nih.gov/pubmed/15953311
(E.C.2) http://www.ncbi.nlm.nih.gov/pubmed/12480795
(E.C.7) http://www.ncbi.nlm.nih.gov/pubmed/21197315
(E.C.9) http://www.ncbi.nlm.nih.gov/pubmed/10998643
(B.A.8) http://www.ncbi.nlm.nih.gov/pubmed/22426836
(E.B.2) http://www.ncbi.nlm.nih.gov/pubmed/2948651
(E.B.3) http://www.ncbi.nlm.nih.gov/pubmed/17355497
(1) https://www.ncbi.nlm.nih.gov/pubmed/24068338
(2) https://www.ncbi.nlm.nih.gov/pubmed/26563803
Sunday, October 28, 2018
The Magic Bean That Processes Anti Chronic Diseases' Activities
A recent study suggested a regular intake of kidney bean may have a potential effect in the prevention and treatment of chronic diseases.
Chronic diseases are medical conditions that last more than 3 months or more and can not be cured.
According to WHO in the article of "Noncommunicable diseases" suggested, "The four main types of noncommunicable diseases are cardiovascular diseases (like heart attacks and stroke), cancers, chronic respiratory diseases (such as chronic obstructed pulmonary disease and asthma) and diabetes"(4).
Some chronic conditions also are correlated with other diseases, such as chronic conditions of high blood cholesterol and pressure are associated to increase the risk of heart attack and stroke.
According to the Center for diseases control and prevention statistic, approximately, over 117 million people worldwide had one or more chronic health conditions. And 1 in 4 adults had two or more chronic health conditions(5).
The chronic diseases are the 7th most common causes of death in 2014(5).
Although most common causes of the chronic condition are either debatable or depending to types of condition. However, some researchers suggested that physical activity, poor nutrition, tobacco use, and excessive alcohol drinking are the most common risk factors.
Chronic diseases today have become a burden of the health care system, according to CDC. In US, the conditions cost over 68% of annual health care expenditures of $2.7 trillion(5).
Depending on types of chronic condition, patients may experience some correlated symptoms
* In Patients with cardiovascular diseases, the symptoms include chest pain, chest tightness, chest pressure and chest discomfort (angina),....and shortness of breath.
* Depending to types of cancer, symptoms may including blood in the urine, hoarseness, persistent lumps or swollen glands. ... and indigestion or difficulty swallowing.
* Patients with chronic respiratory diseases may experience shortness of breath, especially during physical activities, wheezing,... and chest tightness.
* Patients with diabetes may include symptoms of unusual thirst, frequent urination, weight change,........ and extreme fatigue or lack of energy.
Kidney bean is very popular because of its kidney shape, strong flavor, and color of reddish brown in nature. The bean often is an excellent dietary selection with no cholesterol, but a good source of protein and minerals.
According to the University of Colorado Colorado Springs, consumption of kidney bean regularly attenuated the increased glycaemic stress (hyperglycemia and hyperinsulinemia) including diabetes, CVD and cancer.
Dr. Hutchins AM, the lead author said, " (The efficacy of kidney in reduced risk of chronic illness may be attributed to the) glycaemic response and the impact that relationship may have on the risk of developing diabetes, CVD and cancer".
In the study to compared two different illumination conditions during germination (12 h light/12 h dark vs 24 h dark) in lentils (Lensculinaris L.) and kidney beans (Phaseolus vulgaris L.), melatonin content exerted a significantly antioxidant activity in protection against free radicals as well as showing the use of food as preventive strategies in combating chronic diseases through the diet.
Furthermore, the investigation of phenolic-rich extracts obtained from two kinds of common beans, white kidney beans (WKB) and round purple beans (RPB), extracts Phenolic acids and phenolic compounds expressed strong antioxidants and anti-inflammatory activities in reduced the incidence of several chronic diseases that share an inflammatory component.
Dr. García-Lafuente A, the lead researcher in the study said, "common bean extracts may be used as a source of anti-inflammatory agents as well as a dietary complement for health promotion".
Taking together, intake kidney beans regularly may reduce risk and progression of chronic illness through the immunomodulatory effects involved increased antioxidant and ameliorated inflammatory activities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Phaseolus beans: impact on glycaemic response and chronic disease risk in human subjects by Hutchins AM1, Winham DM, Thompson SV. (PubMed)
(2) Effect of illumination on the content of melatonin, phenolic compounds, and antioxidant activity during germination of lentils (Lens culinaris L.) and kidney beans (Phaseolus vulgaris L.) by Aguilera Y1, Liébana R, Herrera T, Rebollo-Hernanz M, Sanchez-Puelles C, Benítez V, Martín-Cabrejas MA. (PubMed)
(3) In vitro anti-inflammatory activity of phenolic rich extracts from white and red common beans by García-Lafuente A1, Moro C2, Manchón N2, Gonzalo-Ruiz A3, Villares A2, Guillamón E2, Rostagno M2, Mateo-Vivaracho L2. (PubMed)
(4) Noncommunicable diseases by WHO
(5) Chronic Diseases: The Leading Causes of Death and Disability in the United States(CDC)
Saturday, October 27, 2018
Infectious Diseases: Scientists Successfully Found the Vitamins That Suppress Over Growth of Candida
Candida albicans are members of a large group of microorganism whose cells contain complex structures enclosed within the membranes, including yeast(2)(3), fungi(4)(5)(6), and mold(6) that live among the gut flora in the human mouth and gastrointestinal tract.
Non-albicans Candida (NAC) species cause 35-65% of all candidaemias in the general patient population(1).
According to joint study, in many cases, biofilm(microorganisms with cells stick to each other on a surface) formation(7) gene mutations(8) and overexpression of genes(9)(10) are often associated with increased candida resistance toward antifungal drugs.
NADPH oxidase (NOX) are enzymes that generate reactive oxygen species by transporting electrons across lipid membranes.to induce cytotoxicity against invading microbes. However, according to the joint study led by Johns Hopkins University Bloomberg School of Public Health, Candida albicans is capable of a ROS burst, using a member of the NOX enzyme family to produce ROS with an aim to drive fungal morphogenesis in the animal host(a).
Vitamin A, B2, C and E as antioxidants and free radical scavengers may have a potential role in inhibited superoxide anion (ROS) radicals caused by overexpression of candida via NADPH oxidase (NOX) enzymes(b).
.
The Anti Over Growth of Candida Vitamins
1. Vitamin B2
Vitamin B2 required for a wide variety of cellular processes plays a key role in energy metabolism and enhances the digestive system in absorbing nutrients and supports the immune system(230)(231) in fighting against bacteria causes of inflammatory disease, including candida(232).
2. Vitamin C
Vitamin C, a water-soluble vitamin and an antioxidant found in high concentrations in immune cells, is not only important in aiding the digestive system in absorbing nutrients, but also enhances the production of white blood cell(233)(234) of the immune system(235) in protection of the body by binding to the harmful bacteria(236) and ingesting them.
3. Vitamin A
Retinoic acid appears to maintain normal skin health by switching on genes and differentiating keratinocytes (immature skin cells)(237) into mature epidermal cells and helps to detox the liver(238).
The vitamin also enhances the immune system(239)(240) in protecting our body through its antimicrobial functions, including Candida albicans(241).
4. Vitamin E
Vitamin E is fat-soluble compounds included both tocopherols and tocotrienols. It not only is a polyphenol antioxidant (242)(246) in scavenging free radicals and microorganisms , but also promotes the immune system in enhanced functions of B-cells(244)(245), the immune cells(245)(247) in the production of antibodies to destroy infectious agents..
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(a) Candida albicans FRE8 encodes a member of the NADPH oxidase family that produces a burst of ROS during fungal morphogenesis by Rossi DCP1, Gleason JE1, Sanchez H2, Schatzman SS1, Culbertson EM1, Johnson CJ2, McNees CA1, Coelho C3, Nett JE2, Andes DR2, Cormack BP4, Culotta VC(PubMed)
(b) Free radical scavenging and antiproliferative properties of Biginelli adducts by da Silva DL1, Reis FS, Muniz DR, Ruiz AL, de Carvalho JE, Sabino AA, Modolo LV, de Fátima A(PubMed)
(1) Non-albicans Candida spp. causing fungaemia: pathogenicity and antifungal resistance by Krcmery V1, Barnes AJ.(PubMed)
(2) Pathogenicity and drug resistance in Candida albicans and other yeastspecies. A review by Mishra NN1, Prasad T, Sharma N, Payasi A, Prasad R, Gupta DK, Singh R.(PubMed)
(3) Multidrug resistance in yeast Candida by Prasad R1, Kapoor K.(PubMerd)
(4) New evidence that Candida albicans possesses additional ATP-binding cassette MDR-like genes: implications for antifungal azole resistance. by Walsh TJ1, Kasai M, Francesconi A, Landsman D, Chanock SJ.(PubMed)
(5) Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters.by Sanglard D1, Kuchler K, Ischer F, Pagani JL, Monod M, Bille J.(PubMed)
(6) Structural analysis of phospho-D-mannan-protein complexes isolated from yeast and mold form cells of Candida albicans NIH A-207 serotype A strain by Shibata N1, Fukasawa S, Kobayashi H, Tojo M, Yonezu T, Ambo A, Ohkubo Y, Suzuki S.(PubMed)
(7) The effect of antifungal combination on transcripts of a subset of drug-resistance genes in clinical isolates of Candida species induced biofilms by Ibrahim NH1, Melake NA2, Somily AM3, Zakaria AS4, Baddour MM5, Mahmoud AZ6(PubMed)
(8) Antifungal drug resistance in pathogenic fungi. by Vanden Bossche H1, Dromer F, Improvisi I, Lozano-Chiu M, Rex JH, Sanglard D.(PubMed)
(9) The genetic basis of fluconazole resistance development in Candida albicans by Morschhäuser J1.(PubMed)
(10) A proteomic approach to understanding the development of multidrug-resistant Candida albicans strains by Kusch H1, Biswas K, Schwanfelder S, Engelmann S, Rogers PD, Hecker M, Morschhäuser J.(PubMed)
(230) Edible mushrooms: improving human health and promoting quality life by Valverde ME1, Hernández-Pérez T1, Paredes-López O1.(PubMed)
(231) [Effect of some vitamins on activity of immunocompetent cells].[Article in Russian]by Nezgovorov DV.(PubMed)
(232) Antioxidants keep the potentially probiotic but highly oxygen-sensitive human gut bacterium Faecalibacterium prausnitzii alive at ambient air by Khan MT1, van Dijl JM1, Harmsen HJ1.(PubMed)
(233) Storing red blood cells with vitamin C and N-acetylcysteine prevents oxidative stress-related lesions: a metabolomics overview by Pallotta V1, Gevi F1, D'alessandro A1, Zolla L1.(PubMed)
(234) Red blood cell metabolism under prolonged anaerobic storage by D'Alessandro A1, Gevi F, Zolla L.(PubMed)
(235) Alterations in antioxidant defense system of workers chronically exposed to arsenic, cadmium and mercury from coal flying ash by Zeneli L1, Sekovanić A, Ajvazi M, Kurti L, Daci N.(PubMed)(236) Indomethacin-induced translocation of bacteria across enteric epithelia is reactive oxygen species-dependent and reduced by vitamin C by Schoultz I1, McKay CM, Graepel R, Phan VC, Wang A, Söderholm J, McKay DM.(PubMed)
(237) Vitamin C derivative ascorbyl palmitate promotes ultraviolet-B-induced lipid peroxidation and cytotoxicity in keratinocytes by Meves A1, Stock SN, Beyerle A, Pittelkow MR, Peus D.(PubMed)
238. Effects of dried fish on antioxidant levels in rat liver by Anilakumar KR1, Khanum F, Krishna KR, Viswanathan KR.(PubMed)
(239) Vitamin A and retinoic acid in T cell-related immunity by Ross AC1.(PubMed)
(240) Vitamin A and immune regulation: role of retinoic acid in gut-associated dendritic cell education, immune protection and tolerance by Cassani B1, Villablanca EJ, De Calisto J, Wang S, Mora JR.(PubMed)(241) Modulatory role of vitamin A on the Candida albicans-induced immune response in human monocytes by Klassert TE1, Hanisch A, Bräuer J, Klaile E, Heyl KA, Mansour MK, Tam JM, Vyas JM, Slevogt H.(PubMed)
(242) [Toxicology of the synthetic antioxidants BHA and BHT in comparison with the natural antioxidant vitamin E].[Article in German]by Kahl R1, Kappus H.(PubMed)
(243) Effectiveness of antioxidants (vitamin C and E) with and without sunscreens as topical photoprotectants by Darr D1, Dunston S, Faust H, Pinnell S.(PubMed)
(244) Immune dysfunction and cytokine production in hemodialysis. Could they be lessened by vitamin E-coated dialyzer membrane by Senatore M, Cecere P, Colombo P, Costantini L, Filiberti O, Piccini G, Peona C, Buemi M, Nicoletti A, Rizzuto G.(PubMed)
(245) Prospective crossover trial of the influence of vitamin E-coated dialyzer membranes on T-cell activation and cytokine induction by Girndt M1, Lengler S, Kaul H, Sester U, Sester M, Köhler H.(PubMed)
(246) Vitamin E and immunity by Moriguchi S1, Muraga M.(PubMed)
(247) The role of vitamin E in T-cell differentiation and the decrease of cellular immunity with aging.by Moriguchi S1.(PubMed)(249) By the way, doctor. I recently saw a TV ad for a product called "coralcalcium," which is supposed to prevent osteoporosis and other diseases. What do you know about it by Robb-Nicholson C.(PubMed)
Thursday, October 25, 2018
Cruciferous Vegetables Dissolve Chemical Carcinogens Before They Can Cause Cancers
Cruciferous vegetables with rich of phytochemicals may be the potential foods that dissolve chemical carcinogens toxic effect before they can induce the onset of cancers, some scientists suggested
Cancers are class of medical condition characterized by cells growth disorderly and uncontrollably in any tissue and organs in the body. In most cases, at the later stage, cancerous cells can travel a distance away to infect other healthy cells and tissue.
Chemical carcinogens are types of chemical compounds that can cause cancer, mostly man-made.
According to the Universidade Federal de Ouro Preto, sulforaphane (SFN), the isothiocyanate (ITC) group of organosulfur compounds found in cruciferous vegetable expressed chemopreventive properties involved detoxification processes of chemical carcinogens.
Certain chemicals, such as benzene, beryllium, asbestos, vinyl chloride, and arsenic are known to induce human carcinogens.
This is tough to believe that exposure to chemical carcinogens in the outdoors, at home, and at work is associated to increase the risk of getting cancer.
According to the Agency for Toxic Substances and Disease Registry, "More than 100,000 chemicals are used by Americans, and about 1,000 new chemicals are introduced each year" and "These chemicals are found in everyday items, such as foods, personal products, packaging, prescription drugs, and household and lawn care products"(4).
The agency also suggested that some chemical carcinogens can be harmful, not all contact with chemicals is dangerous to health(4).
Risk of developing cancer is depended totally on how much, how long, how often, and when you are exposed to these chemicals.
It is true, long-term in contact with chemical carcinogens can lead to DNA alternation, the main cause of early onset of cancers(4).
Some researchers suggested that asbestos, nickel, cadmium, radon, vinyl chloride, benzidene, and benzene may act alone or with other carcinogens to increase the prevalent risk(4)
Occasional exposure to chemicals in adults may be harmful to health, but to induce gene change is impossible.
However, when you are exposed is important because a small exposure in the womb, for example, may be more serious than a small exposure as an adult.
Dr. de Figueiredo SM, the lead author said, " In a dose-dependent manner, ITC inhibits the viability of human cancer cells, modifies epigenetic events that occur in cancer cells and present antiinflammatory effect acting during the initial of uncontrolled cell proliferation." and "Chemical carcinogens are types of cancer caused by chemical toxins in induction of cellular and chromosomes change, DNA damage,... ".
The chemoprotective activity of the vegetable is the result of the significant expression of the antioxidants in exhibited cell cycle arrest and apoptosis in cancer cells as well as acting as the post-initiation stages of carcinogenesis, as a 'suppressing' agent involving the ability to modulate the Nrf2 in reduced damage from oxidative damage.
In fact, besides used as a chemopreventive agent against chemical carcinogenesis, sulforaphane (SFN), the major chemical constituent of cruciferous vegetables also inhibited the drug-metabolizing enzymes that cause activation/neutralization of carcinogenic metabolites and protected normal healthy cells from environmental toxin-induced of cancers.
Furthermore, the phytochemical exhibited the molecular mechanisms responsible for the overall chemopreventive effects on selective cytotoxicity, in reduced oxidate stress, free radicals produced by lipid peroxidation in cells.
In the study of tobacco smoke carcinogens induced chemical tumors, cruciferous vegetable consumption has shown to inversely associate the development of cancer.
In animal experiments. the chemopreventive effects of isothiocyanates, another compound found in cruciferous vegetable, inhibited the metabolic activation of carcinogens by cytochrome P450s, enzymes with function in metabolized potentially toxic compounds.
Taking together, intake of cruciferous vegetables have potential health benefits against environment toxins in cancer development, but due to the small size of the sample, further studies are necessary to address its viability.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Chemoprotection by sulforaphane: keep one eye beyond Keap1 by Myzak MC1, Dashwood RH.(PubMed)
(2) The antioxidant properties of organosulfur compounds (sulforaphane) by de Figueiredo SM1, Binda NS, Nogueira-Machado JA, Vieira-Filho SA, Caligiorne RB.(PubMed)
(3) Role of 4-hydroxynonenal in chemopreventive activities of sulforaphane by Sharma R1, Sharma A, Chaudhary P, Sahu M, Jaiswal S, Awasthi S, Awasthi YC.(PubMed)
(4) Chemicals, Cancer, and You by Agency for Toxic Substances and Disease Registry
Cancers are class of medical condition characterized by cells growth disorderly and uncontrollably in any tissue and organs in the body. In most cases, at the later stage, cancerous cells can travel a distance away to infect other healthy cells and tissue.
Chemical carcinogens are types of chemical compounds that can cause cancer, mostly man-made.
According to the Universidade Federal de Ouro Preto, sulforaphane (SFN), the isothiocyanate (ITC) group of organosulfur compounds found in cruciferous vegetable expressed chemopreventive properties involved detoxification processes of chemical carcinogens.
Certain chemicals, such as benzene, beryllium, asbestos, vinyl chloride, and arsenic are known to induce human carcinogens.
This is tough to believe that exposure to chemical carcinogens in the outdoors, at home, and at work is associated to increase the risk of getting cancer.
According to the Agency for Toxic Substances and Disease Registry, "More than 100,000 chemicals are used by Americans, and about 1,000 new chemicals are introduced each year" and "These chemicals are found in everyday items, such as foods, personal products, packaging, prescription drugs, and household and lawn care products"(4).
The agency also suggested that some chemical carcinogens can be harmful, not all contact with chemicals is dangerous to health(4).
Risk of developing cancer is depended totally on how much, how long, how often, and when you are exposed to these chemicals.
It is true, long-term in contact with chemical carcinogens can lead to DNA alternation, the main cause of early onset of cancers(4).
Some researchers suggested that asbestos, nickel, cadmium, radon, vinyl chloride, benzidene, and benzene may act alone or with other carcinogens to increase the prevalent risk(4)
Occasional exposure to chemicals in adults may be harmful to health, but to induce gene change is impossible.
However, when you are exposed is important because a small exposure in the womb, for example, may be more serious than a small exposure as an adult.
Dr. de Figueiredo SM, the lead author said, " In a dose-dependent manner, ITC inhibits the viability of human cancer cells, modifies epigenetic events that occur in cancer cells and present antiinflammatory effect acting during the initial of uncontrolled cell proliferation." and "Chemical carcinogens are types of cancer caused by chemical toxins in induction of cellular and chromosomes change, DNA damage,... ".
The chemoprotective activity of the vegetable is the result of the significant expression of the antioxidants in exhibited cell cycle arrest and apoptosis in cancer cells as well as acting as the post-initiation stages of carcinogenesis, as a 'suppressing' agent involving the ability to modulate the Nrf2 in reduced damage from oxidative damage.
In fact, besides used as a chemopreventive agent against chemical carcinogenesis, sulforaphane (SFN), the major chemical constituent of cruciferous vegetables also inhibited the drug-metabolizing enzymes that cause activation/neutralization of carcinogenic metabolites and protected normal healthy cells from environmental toxin-induced of cancers.
Furthermore, the phytochemical exhibited the molecular mechanisms responsible for the overall chemopreventive effects on selective cytotoxicity, in reduced oxidate stress, free radicals produced by lipid peroxidation in cells.
In the study of tobacco smoke carcinogens induced chemical tumors, cruciferous vegetable consumption has shown to inversely associate the development of cancer.
In animal experiments. the chemopreventive effects of isothiocyanates, another compound found in cruciferous vegetable, inhibited the metabolic activation of carcinogens by cytochrome P450s, enzymes with function in metabolized potentially toxic compounds.
Taking together, intake of cruciferous vegetables have potential health benefits against environment toxins in cancer development, but due to the small size of the sample, further studies are necessary to address its viability.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Chemoprotection by sulforaphane: keep one eye beyond Keap1 by Myzak MC1, Dashwood RH.(PubMed)
(2) The antioxidant properties of organosulfur compounds (sulforaphane) by de Figueiredo SM1, Binda NS, Nogueira-Machado JA, Vieira-Filho SA, Caligiorne RB.(PubMed)
(3) Role of 4-hydroxynonenal in chemopreventive activities of sulforaphane by Sharma R1, Sharma A, Chaudhary P, Sahu M, Jaiswal S, Awasthi S, Awasthi YC.(PubMed)
(4) Chemicals, Cancer, and You by Agency for Toxic Substances and Disease Registry
Wednesday, October 24, 2018
How to Detox and Nourish Your Immune System, Brain, Liver, Kidney, Skin, Lung and Blood For Optimal Health, Citations Provided By NIH
The western diet contains high saturated fat, trans fat, and other harmful substances such as sugar, caffeine, pesticides, addictive substances, and less in fruits and vegetables.
These types of harmful substances are toxic.
Detoxification is a natural process of our body to maintain the proper function and protect our organs and tissues against toxicity by eliminating toxins accumulated.
When they fail, the toxic accumulations cause a disruption of hormone production, damage the body's detoxification organs and weaken the immune system, leading to hormone imbalance and much chronic illness consequently.
Some researchers suggested that overexpression of toxins may lead to an imbalance of the ratio of free radicals and antioxidants produced by the antioxidant enzymes of tissue, leading to oxidative stress in the induction of cytotoxicity.
Cytotoxicity not only damages healthy cells but also alternates cells DNA transcription, one of the major cause of cancer.
The natural remedies detox and nourish your Immune system, Brain, Liver, Kidney, Skin, Lung, and Blood include
1. Garlic extract
Garlic extract is a widely used medication in the world with a proven record in preventing and treating heart disease, increasing circulation of blood flow, protecting our kidney and liver against injury and damage caused by ROS inducing cytotoxicity.
According to a 2009 study by Tabriz University of Medical Sciences, application of garlic extract in tested mice reserved liver toxicity caused by overdosed on acetaminophen in the induction of oxidative stress and depletion of the host antioxidants, such as glutathione (GSH)(1).
Dr. Anoush M, the lead scientist said, "Acetaminophen, the most commonly sold over-the-counter antipyretic analgesic, is capable of causing severe and sometimes fatal hepatic damage in humans and experimental animals".
The herb also strengthens our system's fighting against the degeneration of our body.
2. Gotu Kola
Gotu Kola is also known as cetenlla asiatica with a strong effect in treating nervous system disorder caused by inflammation and improving alertness and memory.
According to the Inha University Hospital, application of leaf extract exerted a significant activity in reduced oxidative stress induced by injection of dimethylnitrosamine‑induced liver injury in rats(2).
The results of these actions were attributed to the extract in significantly decreased the level of malondialdehyde and increased the levels of host antioxidant enzymes, including superoxide dismutase, glutathione peroxidase, and catalase, and may have provided protection against the deleterious effects of reactive oxygen species.
In metal toxins accumulation by arsenic exposure (20 ppm in drinking water for 4 weeks) injection in tested rats, application of oral supplementation of Centella asiatica (100, 200 or 300 mg kg(-1), orally once daily displayed a strong inhibition of delta-aminolevulinic acid dehydratase (ALAD) activity in induction of increased oxidized glutathione (GSSG) and thiobarbituric acid reactive substance (TBARS) levels(3).
Overexpression of ROS can lead to liver, kidney and brain damage permanently(3).
These result suggested that Gotu Kola antitoxins in the liver, kidney and blood effect(13) may be considered as a co-administration during chelation therapy with a thiol chelator(3).
With enormous antioxidant property, Gotu kola can also rejuvenate the body against the forming of free radicals in induced early aging.
3. Astragalus
Astragalus is used in traditional Chinese medicine for strengthening our body in fighting against diseases and protecting cells from free radicals through it antioxidants activity.
The herbal medicine also is an excellent agent in fighting against virus and bacteria, and restored our body's energy.
According to the Institute of Clinical Pharmacology, Anhui Medical University, extract isolated from the roots of P. lactifloruala and A. membranaceus demonstrated better hepatoprotective activity in compared the to application of individual herb used seperately(4), through antioxidant activity.
Furthermore, injection in animal model suggested that astragalus saponin extracts (AS) process a strong kidneys protective on diabetic rats(5). through reduction of renal pathological changes.
4. Bee Pollen
Bee pollen is said to contain all the essential components of life.
Accoridng to traditional herbal medicine, the herb process tonified activity by correcting the deficient, re balanccing nutrition and improving our immune system as well as rejuvenating our body.
In concerns of Cisplatin (CP), after application to patient with an aim to cure cancers although it is effectively in clinics, however, it could induce toxic effects, researchers at the Fujian Agriculture and Forestry University, conducted an experiment to test whether bee pollen, a natural compound, produced by honey bees has a potential inhibited expression of these toxic effects(6).
The results are so astonishingly, application of bee pollen extract (SCBPE) reversed the damage of liver and kidney caused by Cisplatin (CP) through improving the antioxidant, anti-inflammatory and anti-apoptotic capacity of the body.
Moreover, antioxidant rich bee polen also demostrated a strongly preventive effect against histological changes in the liver and cardiac blood vessels, abnormalities of lipid profile, and the levels of oxidized low density lipoproteins (ox-LDL), asymmetric dimethylarginine (ADMA), angiotensin-converting enzyme (ACE), and angiotensin II (ANG II) caused by a high-fat diet in C57BL₆ mice(7).
5. Dock
Dock contains vitamin C and vitamin A.
The herbal medicine not only promotes a strong immune system, but also dissolves heavy metalaccumulated in our body and prevents muscular degeneration.
According to the Xi'an Jiaotong University Health Science Center, dihydromyricetin (DHM), a bioactive flavonoid component isolated from dock against lung injure and damage caused by injection of LPS(8).
6. Reishi Mushroom
Reishi Mushroom contains ganoderic acids with function in strengthening our immune system's fight against inflammation.
In the study to evaluate the antioxidative effect of hot water extract of the mushroom Ganoderma lucidum on ethanol-induced free radical generation, researchers at the Taipei Medical University Hospital showed that injection of the extract on dose-dependently exhibited antioxidative effect on mouse liver and kidney lipid peroxidation(9).
At the final report, Dr. Shieh YH, the lead scientist said, "the hepatic and renal protective mechanism of Ganoderma lucidum, might be due at least in part to its prominent superoxide scavenging effect. Ganoderma extract could protect the liver and kidney from superoxide induced hepatic and renal damages".
The hot water extracts also was shown to have antioxidative effect against heart and chemical toxicity(12), according to the Mackay Memorial Hospital(10).
Furthermore, the mushroom polysaccharides protect skin fibroblasts against UVB-induced photoaging(11)..
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The protective effects of garlic extract against acetaminophen-induced oxidative stress and glutathione depletion by Anoush M1, Eghbal MA, Fathiazad F, Hamzeiy H, Kouzehkonani NS(PubMed)
(2) Protective effects of Centella asiatica leaf extract on dimethylnitrosamine‑induced liver injury in rats by Choi MJ1, Zheng HM1, Kim JM2, Lee KW3, Park YH3, Lee DH(PubMed)
(3) Effect of Centella asiatica on arsenic induced oxidative stress and metal distribution in rats by Gupta R1, Flora SJ(PubMed)
(4) Protective effect of extract from Paeonia lactiflora and Astragalus membranaceus against liver injury induced by bacillus Calmette-Guérin and lipopolysaccharide in mice by Sun WY1, Wei W, Gui SY, Wu L, Wang H(PubMed)
(5) [Protective effect of astragalus saponin extracts on kidneys of diabetic rats].[Article in Chinese] by Xiao F, Hu YG, Wu SN, Shou QY, Cai YQ, Wang HM, Wang H(PubMed)
(6) Protective effect of Schisandra chinensis bee pollen extract on liver and kidney injury induced by cisplatin in rats by Huang H1, Shen Z1, Geng Q2, Wu Z2, Shi P3, Miao X(PubMed)
(7) Protective Effect of Polyphenol-Rich Extract from Bee Pollen in a High-Fat Diet by Rzepecka-Stojko A1, Kabała-Dzik A2, Kubina R3, Jasik K4, Kajor M5, Wrześniok D6, Stojko J(PubMed)
(8) Protective effect of dihydromyricetin on LPS-induced acute lung injury by Wang B1, Xiao Y1, Yang X1, He Y1, Jing T1, Wang W2, Zhang J3, Lin R(PubMed)
(9) Evaluation of the hepatic and renal-protective effects of Ganoderma lucidum in mice by Shieh YH1, Liu CF, Huang YK, Yang JY, Wu IL, Lin CH, Li SC(PubMed)
(10) Antioxidant activity of Ganoderma lucidum in acute ethanol-induced heart toxicity by Wong KL1, Chao HH, Chan P, Chang LP, Liu CF(PubMed)
(11) Antioxidant activity of Ganoderma lucidum in acute ethanol-induced heart toxicity by Wong KL1, Chao HH, Chan P, Chang LP, Liu CF.(PubMed)
(12) Protective effect of vanilloids against chemical stress on the white-rot fungus Ganoderma lucidum by Kuhar F1, Papinutti L(PubMed)
(13) Effects of some thiol chelators on enzymatic activities in blood, liver and kidneys of acute arsenic (III) exposed mice by Tripathi N1, Flora SJ(PubMed)
Tuesday, October 23, 2018
Common Types of Free Radicals That Cause Oxidation and Cytotoxicity
Free radicals are atoms, molecules, or ions with unpaired electrons through chemical bonds with other atoms or molecules during a chemical reaction. As oxidants or reductants, they can donate or accept an electron from other molecules to exhibit chain and domino's effects.
They may have positive, negative or zero charges.
The unpaired electrons cause radicals to be highly chemically reactive in the human body, leading to aging and cancers.
However, injection of free radicals into cancer cells may induce cells death and inhibit tumor proliferation.
These results suggested that free radicals have a duo function in mediated cellular processes. On one hand, they cause alternation of DNA of healthy cells into cancerous cells. On the other hand, free radical can cause apoptosis of cancer cells through cytotoxicity(1).
Some researchers went even further to suggest that free radical such as H2O2 signaling pathway plays an essential role in the creation of a bridge between insulin receptor and mitochondrial function in neurons(1)
And, overexpression of antioxidant caused by intake of supplementation can also be dangerous to signaling role in cells(2) and increase risk motility(3). For example, integral mitochondrial Manganese superoxide dismutase µMnSOD) protein possesses peroxidase activity when the enzyme is overexpressed in mitochondria(2).
Most common Types of Free radical include
1. Hydroxyl radical (OH•)
The hydroxyl radical is the neutral form of the hydroxide ion (OH–). It is produced from the decomposition of hydroperoxides (ROOH) by the reaction of an elevation in energy level above an arbitrary baseline energy state molecular oxygen with water.
The hydroxyl radical is highly reactive and has a very short in vivo half-life of approx. 10−9 s This makes it a very dangerous compound to the organism. Hydroxyl radical cannot be eliminated by an enzymatic reaction and can damage virtually all types of macromolecules: carbohydrates, nucleic acids (mutations), lipids (lipid peroxidation) and amino acids, that makes it a very danger compound to shorten the lifespan of a human being.
2. Superoxide anion radical (O2–•)
A superoxide anion is a compound that possesses an atom or molecule in which the total number of electrons is not equal to the total number of protons, giving it a net positive or negative electrical charge with the chemical formula O2− with one unpaired electron, leading to the generating of superoxide anion free radical.
Mutations in the gene coding for the NADPH oxidase cause immune deficiency chronic granulomatous disease, leading to extreme susceptibility to infection and pathogenesis of many diseases, including aging.
3. Singlet oxygen
Singlet oxygen is the common name used for the diamagnetic form of molecular oxygen (O2), which is less stable than the normal triplet oxygen. In the biological study, species, Singlet oxygen causes oxidation of LDL cholesterol and resultant cardiovascular effects.
Since singlet oxygen with activation by light can produce severe photosensitivity of skin, leading to skin defects.
4. Hydrogen peroxide
Hydrogen peroxide (H2O2) is the simplest peroxide, a clear liquid, slightly more viscous than water, that appears colorless in dilute solution.
It is considered a highly reactive oxygen species because of its strong oxidizing capacity.
A study published in Nature found that hydrogen peroxide plays a role in the immune system by signaling the white blood cells to converge on the site of damage. The process leads to white blood cells did not accumulate at the site of damage, but somewhere else if the gene in the production of hydrogen peroxide is altered, causing higher levels of hydrogen peroxide and white blood cells in their lungs accumulation in the lung than healthy people.
5. Lipid peroxyl free radical
Lipid peroxidation is a process in which free radicals steal electrons from the lipids in cell membranes, most often affecting polyunsaturated fatty acids, resulting in damaging to the cell membrane, which consists mainly of lipids, because of chain reaction after initial oxidating by producing even more lipid peroxyl free radicals if not bought under controlled fast enough.
6. Nitric oxide
Nitric oxide is a chemical compound with chemical formula NO. Even though low levels of NO production are important in protecting the liver from ischemic damage and contribute to proper smooth muscle contraction and growth, but its free radical and toxic nature can cause DNA damage and inflammation.
7. Alkoxyl radical
Alkoxyl radical which is an alkyl (carbon and hydrogen chain) group singular bonded to oxygen can result in cellular damage caused by oxyfluorfen, a herbicide.
8. Peroxynitrite
Peroxynitrite is the anion with the formula ONOO−reacted quickly with carbon dioxide, leading to forming of carbonate and nitrogen dioxide radicals.
If the two radicals do not recombine to form carbon dioxide and nitrate, they can cause peroxynitrite-related cellular damage.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Recognition of Functional Roles of Free Radicals by István Bókkon(PMC)
(2) The peroxidase activity of mitochondrial superoxide dismutase. Free Radic Biol. by Ansenberger-Fricano K, Silva Ganini DD, Mao M, Chatterjee S, Dallas S, Mason RP, Stadler K, Santos JH, Bonini MG(PubMed)
(3) The neglected significance of "antioxidative stress".by Poljsak B, Milisav I (PubMed)
They may have positive, negative or zero charges.
The unpaired electrons cause radicals to be highly chemically reactive in the human body, leading to aging and cancers.
However, injection of free radicals into cancer cells may induce cells death and inhibit tumor proliferation.
These results suggested that free radicals have a duo function in mediated cellular processes. On one hand, they cause alternation of DNA of healthy cells into cancerous cells. On the other hand, free radical can cause apoptosis of cancer cells through cytotoxicity(1).
Some researchers went even further to suggest that free radical such as H2O2 signaling pathway plays an essential role in the creation of a bridge between insulin receptor and mitochondrial function in neurons(1)
And, overexpression of antioxidant caused by intake of supplementation can also be dangerous to signaling role in cells(2) and increase risk motility(3). For example, integral mitochondrial Manganese superoxide dismutase µMnSOD) protein possesses peroxidase activity when the enzyme is overexpressed in mitochondria(2).
Most common Types of Free radical include
1. Hydroxyl radical (OH•)
The hydroxyl radical is the neutral form of the hydroxide ion (OH–). It is produced from the decomposition of hydroperoxides (ROOH) by the reaction of an elevation in energy level above an arbitrary baseline energy state molecular oxygen with water.
The hydroxyl radical is highly reactive and has a very short in vivo half-life of approx. 10−9 s This makes it a very dangerous compound to the organism. Hydroxyl radical cannot be eliminated by an enzymatic reaction and can damage virtually all types of macromolecules: carbohydrates, nucleic acids (mutations), lipids (lipid peroxidation) and amino acids, that makes it a very danger compound to shorten the lifespan of a human being.
2. Superoxide anion radical (O2–•)
A superoxide anion is a compound that possesses an atom or molecule in which the total number of electrons is not equal to the total number of protons, giving it a net positive or negative electrical charge with the chemical formula O2− with one unpaired electron, leading to the generating of superoxide anion free radical.
Mutations in the gene coding for the NADPH oxidase cause immune deficiency chronic granulomatous disease, leading to extreme susceptibility to infection and pathogenesis of many diseases, including aging.
3. Singlet oxygen
Singlet oxygen is the common name used for the diamagnetic form of molecular oxygen (O2), which is less stable than the normal triplet oxygen. In the biological study, species, Singlet oxygen causes oxidation of LDL cholesterol and resultant cardiovascular effects.
Since singlet oxygen with activation by light can produce severe photosensitivity of skin, leading to skin defects.
4. Hydrogen peroxide
Hydrogen peroxide (H2O2) is the simplest peroxide, a clear liquid, slightly more viscous than water, that appears colorless in dilute solution.
It is considered a highly reactive oxygen species because of its strong oxidizing capacity.
A study published in Nature found that hydrogen peroxide plays a role in the immune system by signaling the white blood cells to converge on the site of damage. The process leads to white blood cells did not accumulate at the site of damage, but somewhere else if the gene in the production of hydrogen peroxide is altered, causing higher levels of hydrogen peroxide and white blood cells in their lungs accumulation in the lung than healthy people.
5. Lipid peroxyl free radical
Lipid peroxidation is a process in which free radicals steal electrons from the lipids in cell membranes, most often affecting polyunsaturated fatty acids, resulting in damaging to the cell membrane, which consists mainly of lipids, because of chain reaction after initial oxidating by producing even more lipid peroxyl free radicals if not bought under controlled fast enough.
6. Nitric oxide
Nitric oxide is a chemical compound with chemical formula NO. Even though low levels of NO production are important in protecting the liver from ischemic damage and contribute to proper smooth muscle contraction and growth, but its free radical and toxic nature can cause DNA damage and inflammation.
7. Alkoxyl radical
Alkoxyl radical which is an alkyl (carbon and hydrogen chain) group singular bonded to oxygen can result in cellular damage caused by oxyfluorfen, a herbicide.
8. Peroxynitrite
Peroxynitrite is the anion with the formula ONOO−reacted quickly with carbon dioxide, leading to forming of carbonate and nitrogen dioxide radicals.
If the two radicals do not recombine to form carbon dioxide and nitrate, they can cause peroxynitrite-related cellular damage.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Recognition of Functional Roles of Free Radicals by István Bókkon(PMC)
(2) The peroxidase activity of mitochondrial superoxide dismutase. Free Radic Biol. by Ansenberger-Fricano K, Silva Ganini DD, Mao M, Chatterjee S, Dallas S, Mason RP, Stadler K, Santos JH, Bonini MG(PubMed)
(3) The neglected significance of "antioxidative stress".by Poljsak B, Milisav I (PubMed)
Monday, October 22, 2018
The Phytochemicals That Inhibit Kidney Cancer Cells
Lentils' (plant sources') lectin may be considered as biomarkers for detection of the early stage of varies types of cancer and treatment of renal cancer, some scientists suggested.
Lentil, a type of pulse and tiny legume that can be cooked quickly and rich in protein and fiber is a bushy annual plant of genus Lens to the Fabaceae family, native to the Middle East.
Kidney Cancer is a medical condition characterized by irregular cells growth in the tissue of kidneys.
At the later stage, the cancerous cells may travel a distance way to infect other organs' tissues.
For example, if kidney cancer spread to the lung is called kidney cancer with lung metastases.
At the very early stage of the kidney, cancerous tumors that are localized in the surface of the kidneys.
The most common type of kidney cancer is renal cell cancer.
The kidney is of 3 main detoxified organs with the main function of filtering water and waste from your blood.
The causes of kidney cancer are unknown, but some researcher suggested that genetic mutation, cigarette smoking, obese, family history,..... and exposed to chemicals, such as asbestos and benzene are all associated to increased risk of kidney cancer.
The cancer is only infected approximately 2% of the general population and screening test is only designated for kidney cancer in people who are at higher risk of the disease.
In the UK, The survival rate of early diagnosis of the early stage of kidney cancer is very high with five-year survival rates for renal cancer of 70-94% for localized tumors
According to statistics reported by Dr. Lewis G, the lead author, " Kidney cancers account for 2-3% of all adult malignancies in the UK. Men are predominantly affected by renal cancer with an average age at diagnosis of 64 years. Renal (or clear) cell carcinoma (RCC) accounts for 90% of kidney cancers"(4) and "RCC should be suspected in the presence of localized symptoms such as flank pain, a loin mass or haematuria; constitutional upset including weight loss, pyrexia and/or night sweats; or with unexplained laboratory tests"(4).
Imaging tests such as computed tomography (CT) or magnetic resonance imaging (MRI), are the best to spot cancer in patients who are at high risk and susceptible to kidney cancer.
According to the investigation of plant lectin effect in risk of cancers, by resisting digestion, lectins after intake maintained full biological activity in binding to the cancer cell remembrances or. and receptors to induce cytotoxicity, thus reducing cancer cell proliferation and inhibiting tumor growth.
lectins can also incorporate into cancer cell as an antigen to cause agglutination and/or aggregation in the induction of cytolysis and inhibit expression of polyamines, small organic cations that are essential for cancer cells to grow.
Furthermore, plant lectins altered the production of various interleukins that are essential importance for the function of both innate and adaptive immunity by activated certain protein kinases in regulating signal transduction pathways in control cancer cells process in the induction of tumor progression.
Additionally, lectins can also bind to cancer cell mutated ribosomes, a cell structure that makes protein and inhibits protein synthesis, thus disrupting the critical cellular processes necessary for sustained cancer cell growth and modified the cancer cell phase 1 division and G2/M phase cell cycle arrest.
Interestingly, injection of lectins also inhibited telomerase expression in cancer cell activity in maintaining tumor progression and angiogenesis in the stimulated production of the new blood vessel to provide nutrients and oxygen to cancer cells proliferation and tumor expansion.
In clear-cell renal cell carcinoma (ccRCC), Galectin-9 (Gal-9), an animal lectin injection exerted a significant effect in inhibited cancer cell proliferation through binding to β-galactoside which is important to provide energy to tumor survival.
Further investigation of the expression of Gal-9 in a total of in 196 patients with ccRCC who underwent nephrectomy, with 48/196 patients died and 61/196 patients suffered recurrence to assess the prognostic value of Gal-9, suggested that Gal-9 expression not only associates positively with tumor size but also induces a direct impact in the relative survival ratio, used to predict overall survival (OS) and recurrence-free survival (RFS) of patients.
Indeed, high levels of Gal-9 was found to associate poor survival and early recurrence and the expression of lectin also can be considered as a biomarker in diagnosed clear-cell renal cell carcinoma (ccRCC) in early stage and lower of grade of tumor, node, and metastasis in patients who are at higher risk of the kidney cancer developing.
The finding evidence suggested that lectins from all sources may be considered as therapeutic substances and biomarkers for treatment and monitoring the progression of kidney cancer.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Lectin reactivity of alpha-fetoprotein in a case of renal cell carcinoma by Taketa K1, Ichikawa E, Sakuda H, Iwamasa T, Hayakawa M, Taga H, Hirai H.(PubMed)
(2) Lectins as bioactive plant proteins: a potential in cancer treatment by De Mejía EG1, Prisecaru VI. (PubMed)
(3) Galectin-9 predicts postoperative recurrence and survival of patients with clear-cell renal cell carcinoma by Fu H1, Liu Y, Xu L, Liu W, Fu Q, Liu H, Zhang W, Xu J.(PubMed)
(4) Early diagnosis improves survival in kidney cancer by Lewis G1, Maxwell AP(PubMed)ll
Beware of The Major Side Effect of Kidney Beans - The Severe Intestinal Atrophy, Studies Reveal
The use of plants for healing purposes have been predated long before the existence of modern medicine.
Herbal plants have formed a fundamental source for conventional medicine in the discovery of single-ingredient medication, including aspirin (from willow bark), quinine (from cinchona bark), and morphine (from the opium poppy)......
Intestinal atrophy is the abnormality of a small intestine mucous membrane, in most cases caused by bacterial infection.
However, certain diseases such as Celiac disease may precipitate the occurrence of intestinal atrophy.
If a patient incidentally consumes foods containing the protein gluten, the allergic foods may trigger immune overexpression in attacking the intestinal villi.
Intestinal atrophy can also be caused by intake of certain medication, including immune suppressors, antibiotics such as neomycin, and the anti-inflammatory medication.
Patients in the early stage of the condition may only experience some abdominal discomforts.
As the infection progress, infectious persons may develop diarrhea, weight loss, abdominal pain, and fatigue.
Some researchers suggested, intestinal atrophy is a serious condition, as the ‘villi’ or ‘microvilli’, damage to some extents, the condition may increase the risk of intestinal permeability and most autoimmune diseases.
According to the Josai University, glutathione (GSH), an antioxidant found in plants, animals, fungi, and some bacteria and archaea may have a profound effect in reduced expression through enhances jejunal regenerative potential to minimize intestinal mucosal atrophy by diminishing fasting-mediated ROS generation and intestinal lining cells apoptosis and enhancing cell proliferation(4)..
These result suggested that oral glutathione (GSH) administration processes a strong activity in alleviated the effects of fasting-induced intestinal atrophy in the small intestinal mucosa.
Intake of kidney beans may result in increased risk of the developed intestinal atrophy, some scientists suggested.
Kidney beans with kidney shape, strong flavor, and color of reddish brown in nature are often the excellent dietary selection with no cholesterol, but a good source of protein and minerals.
According to the University of Utrecht, an animal fed with kidney bean induced mucosal atrophy microscopically causing atrophy and dissection of the intestinal villus in association to lengthen crypts with cells in increased mitotic activity in compared to than normal tissues.
In compared to control, kidney bean intake significantly decreased the goblet cells in secrete gel-forming mucins, the major components of mucus but increased in the crypt region, a gland found in the intestinal epithelium lining of the small intestine and large intestine.
Dr. Kik MJ, the lead author of the study said, " feeding Phaseolus vulgaris beans reduced the digestive and absorptive capacity of the mucosa, resulting in weight loss and diarrhea in affected pigs".
In a randomized study with mice fed to chow, elemental diet, elemental diet plus concanavalin-A and elemental diet plus phytohaemagglutinin groups, group fed phytohaemagglutinin showed a strong effect of chemical compound lectin in inducing cell proliferation in the small intestine and crypt fission of the middle and distal small intestine in compared to other groups.
The study also showed that phytohaemagglutinin with a high amount of lectin also induced intestinal atrophy by affecting the gastric function and mobility through increased secretion of the hormone in regulated gastric acid (HCl).
In fact, the effects of lectins cause of significant gastric trophy on the small intestine and colon may vary between different sites in the gastrointestinal tract.
In support to the above analysis, the Christian-Albrechts-Universität study with 30 day old male rats pair fed for 10 days with lactalbumin as a control diet or lactalbumin plus PHA or purified soybean trypsin inhibitor (STI) as a positive control (42 mg/rat/day) with or without 20 micrograms of the cholecystokinin A (CCK-A) antagonist MK 329, researchers found that oral administration of phytohaemagglutinin (PHA) in rats dose-dependently induces growth of the small intestine through significantly increased CCK plasma levels from 0.75 to 6.67 (SEM 2.23) compared with 2.3 (0.35) pM in the control group.
The result of phytohaemagglutinin (PHA) intake in the exhibit the intestine atrophy may be attributed to the lectin levels in increased production of hormone cholecystokinin in the stimulated additional release of bile into the intestine.
Taking together, intake of kidney bean should be taken with care with patients with digestive problems as the level of lectin may induce intestinal atrophy.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Pathologic changes of the small intestinal mucosa of pigs after feeding Phaseolusvulgaris beans by Kik MJ1, Huisman J, van der Poel AF, Mouwen JM(PubMed)
(2) Lectins can reverse the dsstal intestinal atrophy associated with elemental diets in mice M by SASAKI*, A. J. FITZGERALD*, G. GRANT , M. A. GHATEIà, N. A. WRIGHT* & R. A. GOODLAD§(Wiley online Library)
(3) Red kidney bean lectin is a potent cholecystokinin releasing stimulus in the rat inducing pancreatic growth byK-H Herziga, S Bardoczc, G Grantc, R Nustedeb, U R Fölscha, A Pusztaic(BMJ Journals)
Herbal plants have formed a fundamental source for conventional medicine in the discovery of single-ingredient medication, including aspirin (from willow bark), quinine (from cinchona bark), and morphine (from the opium poppy)......
Intestinal atrophy is the abnormality of a small intestine mucous membrane, in most cases caused by bacterial infection.
However, certain diseases such as Celiac disease may precipitate the occurrence of intestinal atrophy.
If a patient incidentally consumes foods containing the protein gluten, the allergic foods may trigger immune overexpression in attacking the intestinal villi.
Intestinal atrophy can also be caused by intake of certain medication, including immune suppressors, antibiotics such as neomycin, and the anti-inflammatory medication.
Patients in the early stage of the condition may only experience some abdominal discomforts.
As the infection progress, infectious persons may develop diarrhea, weight loss, abdominal pain, and fatigue.
Some researchers suggested, intestinal atrophy is a serious condition, as the ‘villi’ or ‘microvilli’, damage to some extents, the condition may increase the risk of intestinal permeability and most autoimmune diseases.
According to the Josai University, glutathione (GSH), an antioxidant found in plants, animals, fungi, and some bacteria and archaea may have a profound effect in reduced expression through enhances jejunal regenerative potential to minimize intestinal mucosal atrophy by diminishing fasting-mediated ROS generation and intestinal lining cells apoptosis and enhancing cell proliferation(4)..
These result suggested that oral glutathione (GSH) administration processes a strong activity in alleviated the effects of fasting-induced intestinal atrophy in the small intestinal mucosa.
Intake of kidney beans may result in increased risk of the developed intestinal atrophy, some scientists suggested.
Kidney beans with kidney shape, strong flavor, and color of reddish brown in nature are often the excellent dietary selection with no cholesterol, but a good source of protein and minerals.
According to the University of Utrecht, an animal fed with kidney bean induced mucosal atrophy microscopically causing atrophy and dissection of the intestinal villus in association to lengthen crypts with cells in increased mitotic activity in compared to than normal tissues.
In compared to control, kidney bean intake significantly decreased the goblet cells in secrete gel-forming mucins, the major components of mucus but increased in the crypt region, a gland found in the intestinal epithelium lining of the small intestine and large intestine.
Dr. Kik MJ, the lead author of the study said, " feeding Phaseolus vulgaris beans reduced the digestive and absorptive capacity of the mucosa, resulting in weight loss and diarrhea in affected pigs".
In a randomized study with mice fed to chow, elemental diet, elemental diet plus concanavalin-A and elemental diet plus phytohaemagglutinin groups, group fed phytohaemagglutinin showed a strong effect of chemical compound lectin in inducing cell proliferation in the small intestine and crypt fission of the middle and distal small intestine in compared to other groups.
The study also showed that phytohaemagglutinin with a high amount of lectin also induced intestinal atrophy by affecting the gastric function and mobility through increased secretion of the hormone in regulated gastric acid (HCl).
In fact, the effects of lectins cause of significant gastric trophy on the small intestine and colon may vary between different sites in the gastrointestinal tract.
In support to the above analysis, the Christian-Albrechts-Universität study with 30 day old male rats pair fed for 10 days with lactalbumin as a control diet or lactalbumin plus PHA or purified soybean trypsin inhibitor (STI) as a positive control (42 mg/rat/day) with or without 20 micrograms of the cholecystokinin A (CCK-A) antagonist MK 329, researchers found that oral administration of phytohaemagglutinin (PHA) in rats dose-dependently induces growth of the small intestine through significantly increased CCK plasma levels from 0.75 to 6.67 (SEM 2.23) compared with 2.3 (0.35) pM in the control group.
The result of phytohaemagglutinin (PHA) intake in the exhibit the intestine atrophy may be attributed to the lectin levels in increased production of hormone cholecystokinin in the stimulated additional release of bile into the intestine.
Taking together, intake of kidney bean should be taken with care with patients with digestive problems as the level of lectin may induce intestinal atrophy.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Pathologic changes of the small intestinal mucosa of pigs after feeding Phaseolusvulgaris beans by Kik MJ1, Huisman J, van der Poel AF, Mouwen JM(PubMed)
(2) Lectins can reverse the dsstal intestinal atrophy associated with elemental diets in mice M by SASAKI*, A. J. FITZGERALD*, G. GRANT , M. A. GHATEIà, N. A. WRIGHT* & R. A. GOODLAD§(Wiley online Library)
(3) Red kidney bean lectin is a potent cholecystokinin releasing stimulus in the rat inducing pancreatic growth byK-H Herziga, S Bardoczc, G Grantc, R Nustedeb, U R Fölscha, A Pusztaic(BMJ Journals)
Sunday, October 21, 2018
The Magic Bean That Processes Anti Chronic Diseases' Activities
The use of plants for healing purposes has been predated long before the existence of modern medicine.
A recent study suggested a regular intake of kidney bean may have a potential effect in the prevention and treatment of chronic diseases.
Chronic diseases are medical conditions that last more than 3 months or more and can not be cured.
According to WHO in the article of "Noncommunicable diseases" suggested, "The four main types of noncommunicable diseases are cardiovascular diseases (like heart attacks and stroke), cancers, chronic respiratory diseases (such as chronic obstructed pulmonary disease and asthma) and diabetes"(4).
Some chronic conditions also are correlated with other diseases, such as chronic conditions of high blood cholesterol and pressure are associated to increase the risk of heart attack and stroke.
According to the Center for diseases control and prevention statistic, approximately, over 117 million people worldwide had one or more chronic health conditions. And 1 in 4 adults had two or more chronic health conditions(5).
The chronic diseases are the 7th most common causes of death in 2014(5).
Although most common causes of the chronic condition are either debatable or depending on types of condition. However, some researchers suggested that physical activity, poor nutrition, tobacco use, and excessive alcohol drinking are the most common risk factors.
Chronic diseases today have become a burden of the health care system, according to CDC. In the US, the conditions cost over 68% of annual health care expenditures of $2.7 trillion(5).
Depending on types of chronic condition, patients may experience some correlated symptoms
* In Patients with cardiovascular diseases, the symptoms include chest pain, chest tightness, chest pressure and chest discomfort (angina),....and shortness of breath.
* Depending to types of cancer, symptoms may including blood in the urine, hoarseness, persistent lumps or swollen glands. ... and indigestion or difficulty swallowing.
* Patients with chronic respiratory diseases may experience shortness of breath, especially during physical activities, wheezing,... and chest tightness.
* Patients with diabetes may include symptoms of unusual thirst, frequent urination, weight change,........ and extreme fatigue or lack of energy.
Kidney bean is very popular because of its kidney shape, strong flavor, and color of reddish brown in nature. The bean often is an excellent dietary selection with no cholesterol, but a good source of protein and minerals.
According to the University of Colorado Colorado Springs, consumption of kidney bean regularly attenuated the increased glycaemic stress (hyperglycemia and hyperinsulinemia) including diabetes, CVD and cancer.
Dr. Hutchins AM, the lead author said, " (The efficacy of kidney in reduced risk of chronic illness may be attributed to the) glycaemic response and the impact that relationship may have on the risk of developing diabetes, CVD and cancer".
In the study to compared two different illumination conditions during germination (12 h light/12 h dark vs 24 h dark) in lentils (Lensculinaris L.) and kidney beans (Phaseolus vulgaris L.), melatonin content exerted a significantly antioxidant activity in protection against free radicals as well as showing the use of food as preventive strategies in combating chronic diseases through the diet.
Furthermore, the investigation of phenolic-rich extracts obtained from two kinds of common beans, white kidney beans (WKB) and round purple beans (RPB), extracts Phenolic acids and phenolic compounds expressed strong antioxidants and anti-inflammatory activities in reduced the incidence of several chronic diseases that share an inflammatory component.
Dr. García-Lafuente A, the lead researcher in the study said, "common bean extracts may be used as a source of anti-inflammatory agents as well as a dietary complement for health promotion".
Taking together, intake kidney beans regularly may reduce risk and progression of chronic illness through the immunomodulatory effects involved increased antioxidant and ameliorated inflammatory activities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Phaseolus beans: impact on glycaemic response and chronic disease risk in human subjects by Hutchins AM1, Winham DM, Thompson SV.(PubMed)
(2) Effect of illumination on the content of melatonin, phenolic compounds, and antioxidant activity during germination of lentils (Lens culinaris L.) and kidney beans (Phaseolus vulgaris L.) by Aguilera Y1, Liébana R, Herrera T, Rebollo-Hernanz M, Sanchez-Puelles C, Benítez V, Martín-Cabrejas MA.(PubMed)
(3) In vitro anti-inflammatory activity of phenolic rich extracts from white and red common beans by García-Lafuente A1, Moro C2, Manchón N2, Gonzalo-Ruiz A3, Villares A2, Guillamón E2, Rostagno M2, Mateo-Vivaracho L2.(PubMed)
(4) Noncommunicable diseases by WHO
(5) Chronic Diseases: The Leading Causes of Death and Disability in the United States(CDC)
Saturday, October 20, 2018
How to Prevent Immune Disorder, Cardiac and Infectious Diseases Caused By Thrombosis Naturally
Fennel may have a potential and positive effect to act as antithrombotic medicine in reduced hyper blood coagulation in initiated some forms of immune disorder, cardiac and infectious diseases, some scientists suggested.
Coagulation abnormalities are common medical conditions associated to patients in critical illness.
Dr. de Laforcade A, in the article "Diseases associated with thrombosis" said, "Traditionally, clinically relevant coagulation disorders have consisted mostly of bleeding associated with advanced stages of disseminated intravascular coagulation or toxin ingestion" and "Targeting those populations most at risk for thrombotic complications are necessary for better understanding the need for prophylactic anticoagulant therapy.".
According to medical literature, the function of the antithrombotic agent used in conventional medicine can be divided into 2 categories, for the prevention or treatment of a dangerous blood clot (acute thrombus) therapeutically.
Blood coagulation is very dangerous if it is untreated.
People who are hypercoagulable are associated to increase risk of blood clots developing in the arteries (blood vessels that carry blood away from the heart) and veins (blood vessels that carry blood to the heart), leading to stroke(4), heart attack(5), severe hip and leg pain(6), difficulty walking(7),...... epidemiological studies strongly suggested.
In-depth analysis, complications of untreated thrombosis are broader than general belief, including many forms of the immune-mediated disease, cardiac disease and infectious diseases(9).
Some researchers suggested that implications for communicating about family history of thrombosis may be necessary as it is one of the common risk factors in the increased onset of the condition.
People having the above symptoms together with the family history of blood clot should be diagnosed early to confirm or rule out such condition.
Early diagnosis of thrombosis is associated to increase survival and reduce the risk of complications.
Fennel (Foeniculum vulgare) is a plant species of genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean, used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...
In the screen of the potential effect of essential oils extracted from fennel in guinea pig and rat plasma to assess antiplatelet activity and inhibition of clot retraction, researchers at the Università di Parma launched an investigation in compared a number of essential oil extracts from numbers of the herbal plant.
Including in the evaluation are essential oils isolated from Anthemis nobilis L., Artemisia dracunculus L., Cannabis sativa L., Cupressus sempervirens L., Cymbopogon citratus (DC.) Stapf., Curcuma longa L., Foeniculum vulgare L., Hypericum perforatum L., Hyssopus officinalis L., Mentha spicata L., Monarda didyma L., Ocimum basilicum L., Ocotea quixos Kosterm., Origanum vulgare L., Pinus nigra J.F. Arnold, Pinus silvestris L., Piper crassinervium Kunth., Rosmarinus officinalis L., Salvia officinalis L., Salvia sclarea L., Santolina chamaecyparissus L., Thymus vulgaris L., Zingiber officinaie L.
In compared to other essential oil, F. vulgaris essential oil exerted strong anti coagulative activities against ADP, Arachidonic Acid and the Thromboxane A2 agonist U46619, and a good ability to destabilize clot retraction.
Adenine di-Phosphate (ADP), an important platelet agonist that plays a vital role in normal hemostasis and thrombosis. The defective ADP may induce impairment of platelet aggregation.
Arachidonic acid is a polyunsaturated omega-6 fatty acid and the precursor of thromboxane and prostacyclin, two of the most active compounds related to platelet function.
Thromboxane A2 (TxA2) is a potent vasoconstrictor derived from the metabolism of arachidonic acid and has prothrombotic properties.
Further examination also found that tested essential oils, including fennel, demonstrate a significant correlation between antiplatelet potency and phenylpropanoids content.
The phenylpropanoids synthesized by plants from the amino acids phenylalanine and tyrosine are associated to the ability in inhibited blood clotting.
These results suggested that essential oils isolated from fennel and other herbal plants may play a key role for this moiety in the prevention of clot formation, Dr. Tognolini M, the lead author suggested, after taking into account of other co and confounders.
Moreover, anethole, the main fragrance and bioactive compound of fennel also exerted antithrombotic activity involved numbers of mechanisms others than those mentioned above.
According to the Università di Parma, the property of anethole in decreased thrombosis was attributed to the efficacy of the compound in modulated several cell signaling pathways, mainly NF-kB and TNF-α signaling.....
In thrombosis, NF-κB transcription factors, P50/P65 process the ability to regulate the expression of tissue factor (TF), a principal initiator of the coagulation cascade, according to the joint study led by the Institute of Biochemistry and Cell Biology(8).
Tumor necrosis factor is a cell signaling protein (cytokine) best known for its role in systemic inflammation and the acute phase reaction. The protein also plays an essential role in platelet thrombus formation.
The differentiation of anethole's role in decreased thrombosis suggested that activation of inflammatory cytokines by the immune system in the acute phase of infection also stimulates the production of platelets. And inflammatory cytokines also process the ability in enhanced the retraction of the coagulum.
In tested guinea pig, application of anethole enhanced antiplatelet properties through a significant effect in inhibited arachidonic acid, collagen, ADP and U46619-induced aggregation (IC(50) from 4 to 147 microg ml(-1)).
Researchers at Università di Parma also found that
*Anethole, tested in rat aorta with or without endothelium, displays a similar effect to those of NO-independent vasorelaxant activity at antiplatelet concentrations.
* . In vivo, anethole orally administered in a subacute treatment to mice (30 mg kg(-1)day(-1) for 5 days) showed significant antithrombotic activity in preventing the paralysis induced by collagen-epinephrine intravenous injection (70% and 83% protection, respectively).
After taking into account of other co and confounders, Dr. Tognolini M, the lead author at the Università di Parma said, "F. vulgare essential oil, and its main component anethole, a safe antithrombotic activity that seems due to their broad spectrum antiplatelet activity, clot destabilizing effect and vasorelaxant action".
The findings indicated that fennel and its bioactive compound anethole may be considered as a functional food to reduce the risk of diseases associated to thrombosis, such as immune-mediated disease, neoplasia, systemic inflammation and sepsis, cardiac disease, protein-losing states, and infectious diseases(9).
However, further data collection on large sample size and multi centers clinical studies performed with human consumption during the course of the investigation will be necessary to complete the picture of fennel and its bioactive anethole' protective effect against onset thrombosis possibilities.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Comparative screening of plant essential oils: phenylpropanoid moiety as basic core for antiplatelet activity by Tognolini M1, Barocelli E, Ballabeni V, Bruni R, Bianchi A, Chiavarini M, Impicciatore M(PubMed)
(2) Protective effect of Foeniculum vulgare essential oil and anethole in an experimental model of thrombosis by Tognolini M1, Ballabeni V, Bertoni S, Bruni R, Impicciatore M, Barocelli E.(PubMed)
(3) Anethole and Its Role in Chronic Diseases by Aprotosoaie AC1, Costache II2, Miron A3.(PubMed)
(4) Embolic middle cerebral artery occlusion (MCAO) for ischemic stroke with homologous bloodclots in rats by Jin R1, Zhu X1, Li G(PubMed)
(5) How to prevent clots in the legs and lungs. A blockage outside the heart can be just as dangerous as a heart attack.[No authors listed](PubMed)
(6) Deep venous thrombosis in a patient presenting with severe left inguinal and hip pain: a case report by Fidan F1, Alkan BM, Tosun A, Ardçoğlu Ö(PubMed)
(7) Building a protocol to guide mobility in the ICU by Dammeyer J1, Dickinson S, Packard D, Baldwin N, Ricklemann C(PubMed)
(8) NF-κB TRANSCRIPTION FACTOR p50 CRITICALLY REGULATES TISSUE FACTOR IN DEEP VEIN THROMBOSIS by Yi-Dan Li1,#, Bu-Qing Ye1,#, Sheng-Xi Zheng1 , Jin-Tao Wang1 , Jian-Guo Wang2 , Ming Chen1 , Ji-Guo Liu1 , Xin-Hui Pei1,3, Li-Jing Wang4 , Zhi-Xin Lin3 , Kalpna Gupta5 , Nigel Mackman2 , Arne Slungaard5 , Nigel S. Key2 , Jian-Guo Geng(JBC (Papers in Press)
(9) Diseases associated with thrombosis by de Laforcade A(PubMed)
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