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Saturday, April 30, 2016

Most Common Disease of 50plus: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Rheumatoid Arthritis: The Top vitamins

Kyle J. Norton (Scholar)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed. A major restriction of joint movement range was frequent in the shoulder but uncommon in other joints(1).

Types of Musculo-Skeletal disorders in elder(2)

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia



                                                      Rheumatoid Arthritis

Rheumatoid Arthritis is defined a chronic disorder as a result of inflammation, affecting mostly the flexible (synovial) joints and tissues and organs in the body. The disease affects more women than men and generally occurs after the ages of 40, causing diminished quality of life of many elders(1). According to CDC, Musculoskeletal disorders (MSDs) affects over 52 millions of adults in the US alone, including 294,000 children under age 18 with some form of arthritis or rheumatic conditions(2). Rheumatoid Arthritis can induced bone loss through elevating bone resorption without increasing bone formation(4). A cross-sectional population-based study of 1042 patients with rheumatoid arthritis showed that RA patients had an increased risk of death from various causes(4a).



                            The Treatment


B. Treatment in herbal and traditional Chinese medicine
B.3. The Preventive Minerals and Vitamins
2. Top vitamins for rheumatoid arthritis
Free radical scavengers such as vitamins plays an essential role in reduced risk of rheumatoid arthritis
due to their effects in attenuate the expression of free radical and pro inflammatory cytokines(271)(272)
2.1. Vitamin A
According to the Imam Reza Hospital of Tabriz University of Medical Sciences, antioxidant including vitamin A are found to consist a clinical outcomes and oxidative stress in RA(274).
Patient with rheumatoid arthritis are accompanied with the over expression of the levels of serum leptin and other related cytokines, Dr. Xiong RB and the research team at the Southern Medical Universit said, " VitA.....significantly reduced the levels of leptin, TNF-α, IL-6 and CRP and the ESR(Pro inflammatory cytokines) and significantly increased the levels of IL-10 ( limiting autoimmunity and inflammatory responses),.... (of that) may provide a novel approach for the treatment of RA"(273).. All-trans retinoic acid (ATRA), a biologic key metabolite of vitamin A, showed to suppress the clinical and histologic signs of arthritis in the collagen-induced arthritis (CIA) mice model through downregulated the expression of RANK and prevented white blood cell from differentiating into osteoclasts, causing RA( 275).


2.2. Vitamin C
Dietary vitamin C did significantly influence on growth performance and immune response, according to epidemiological studies(276)(277).
Maintaining the balance between pro oxidant and antioxidant levels such as vitamin C and uric acid are important to prevent the insult of free radicals in rheumatoid arthritis, according Dr. Mahajan M and the research team at the Govt. Medical College suggested(278).
Dr Al-Okbi SY said" the majority of nutraceuticals studied possess beneficial effect toward chronic inflammatory diseases,.....anti-inflammatory and antioxidant nutraceuticals may serve as complementary medicine for the management of RA(279).

2.3. Vitamin E
Vitamin A similar to vitamin A are found to consist a clinical outcomes and oxidative stress (274)which has been found to play an important role in the inflammation and parthenogenesis of RA(283).
According to studies, diets containing fish oil and vitamin E not only showed a significant pain reduction in patients but also induced a positive effect on autoimmune disease by decreasing proinflammatory cytokines and lipid mediator(280). In the rat model of collagen-induced arthritis (CIA), oral adminsitration of δ-tocotrienol (10 mg/kg) induced a significant impact in lowering paw edema, through it anti inflammatory effects(281).


2.4. Vitamin D
Vitamin D receptor (VDR), best known for its function in variety of metabolic disorders and in regulation of inflammation, is found to associate to the risk of RA(284), through its expression on reduced risk for FLS-mediated cartilage and bone invasion and erosions by attenuating the pro inflammatory cytokines induced osteoclasts. Vitamin D deficiency is common in rheumatoid arthritis (RA) of which induced pain, fatigue, and limited physical activity as well as poor quality of life(285).
Dr. Kostoglou-Athanassioul and the research team at the Red Cross Hospital, said," vitamin D deficiency is highly prevalent in patients with RA, .......may be linked to disease severity in RA. As vitamin D deficiency has been linked to diffuse musculoskeletal pain, these results have therapeutic implications"(286).




2.5. Vitamin K
Vitamin K, another vitamin is found to plays an important role as an anti-inflammatory nutrient in bone metabolism(287). According to the cross-sectional study of a total of 158 female RA patients (mean age 62.5 years), oral administration VitK2 significant decreased serum CRP, and inhibited the proliferation of fibroblast-like synoviocytes (FLSs) and the development of collagen-induced arthritis (CIA). in a dose-dependent manner(288).

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer recommended by Kyle J. Norton

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

References

(271) Antioxidants and antiinflammatory dietary supplements for osteoarthritis and rheumatoid arthritis by Rosenbaum CC1, O'Mathúna DP, Chavez M, Shields K.(PubMed)
(272) The antioxidant vitamins A, C, E and selenium in the treatment of arthritis: a systematic review of randomized clinical trials by Canter PH1, Wider B, Ernst E.(PubMed)
(273) Effects and mechanisms of vitamin A and vitamin E on the levels of serum leptin and other related cytokines in rats with rheumatoid arthritis by Xiong RB1, Li Q2, Wan WR1, Guo JQ1, Luo BD1, Gan L1.(PubMed)
(274) Beneficial role of antioxidants on clinical outcomes and erythrocyte antioxidant parameters in rheumatoid arthritis patients by Jalili M1, Kolahi S2, Aref-Hosseini SR3, Mamegani ME4, Hekmatdoost A5.(PubMed)
(275) Retinoic acid attenuates rheumatoid inflammation in mice by Kwok SK1, Park MK, Cho ML, Oh HJ, Park EM, Lee DG, Lee J, Kim HY, Park SH(PubMed)
(276) Effect of dietary vitamin C on the growth performance and innate immunity of juvenile cobia (Rachycentron canadum) by Zhou Q1, Wang L, Wang H, Xie F, Wang T.(PubMed)
(277) Effect of vitamin C supplements on cell-mediated immunity in old people by Kennes B, Dumont I, Brohee D, Hubert C, Neve P.(PubMed)
(278) Uric acid a better scavenger of free radicals than vitamin C in rheumatoid arthritis by Mahajan M1, Kaur S, Mahajan S, Kant R.(PubMed)
(279) Nutraceuticals of anti-inflammatory activity as complementary therapy for rheumatoid arthritis by Al-Okbi SY1(PubMed)
(280) Effects of diets containing fish oil and vitamin E on rheumatoid arthritis by Tidow-Kebritchi S1, Mobarhan S.(PubMed)
(281() Vitamin E status during dietary fish oil supplementation in rheumatoid arthritis by Tulleken JE1, Limburg PC, Muskiet FA, van Rijswijk MH.(PubMed)
(282) Therapeutic efficacy of vitamin E δ-tocotrienol in collagen-induced rat model of arthritis by Haleagrahara N1, Swaminathan M2, Chakravarthi S3, Radhakrishnan A2.(PubMed)
(283) Beta-Carotene, Vitamin E, MDA, Glutathione Reductase and Arylesterase Activity Levels in Patients with ActiveRheumatoid Arthritis by Aryaeian N1, Djalali M, Shahram F, Jazayeri Sh, Chamari M, Nazari S.(PubMed)
(284) The vitamin D receptor regulates rheumatoid arthritis synovial fibroblast invasion and morphology. by Laragione T1, Shah A, Gulko PS.(PubMed)
(285) Vitamin D status and its association with quality of life, physical activity, and disease activity in rheumatoid arthritis patients by Raczkiewicz A1, Kisiel B, Kulig M, Tłustochowicz W.(PubMed)
(286) Vitamin D and rheumatoid arthritis by Kostoglou-Athanassiou I1, Athanassiou P, Lyraki A, Raftakis I, Antoniadis C.(PubMed)
(287) Effects of Vitamin K on Matrix Metalloproteinase-3 and Rheumatoid Factor in Women with Rheumatoid Arthritis: A Randomized, Double-Blind, Placebo-Controlled Trial by Shishavan NG1, Gargari BP, Kolahi S, Hajialilo M, Jafarabadi MA, Javadzadeh Y.(PubMed)
(288) Vitamin K and rheumatoid arthritis by Okamoto H1(PubMed)

The #Curablesmoothie of Super Blueberry for Reduced risk and Treatment of Mondor's disease caused by Breast cancer

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Mondor's disease is a medical; condition involved thrombophlebitis of the superficial veins of the breast and anterior chest wall. although the disease is benign but it can be caused at times by breast carcinoma, according to the Ospedale Vittore Buzzi(10) or the complication, of the tunnel procedure in breast biopsy when the distance from the breast lesion to the areolar edge was more than 3 cm(11), as well as thoracoabdominal wall surgeries(12).
Treatment is symptomatic because the disease has proved to be benign and self-limited with corticosteroids, antibiotics, vaccines, and anticoagulants.(13).


The smoothie for prevention and treatment of Mondor's disease caused by Breast cancer
Yield: 2 serving (about 8 ounce each)
1 1/2 cups Blueberries
1 cup rice milk
4-6 ice cubes

1. Place all the ingredients in a blender.
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately.

The dream of finding of a natural ingredient for replacement of serious side effects of chemotherapy for treatment of breast caner has been extremely difficult, probably due to physical differences in testing subjects.

Breast cancer (malignant breast neoplasm) is a cancer originated in the tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma).In 2010, over 250,000 new cases of breast cancer were diagnosed in women in the U.S. alone and the risk of getting invasive breast cancer during life time of a women is 1/8.

Blueberry, a flower plant, belong to the family Eriaceae and native to Northern America contains several essential phytochemicals and nutrients, including, lutein and zeaxanthin, zinc, potassium, phosphorus, iron, calcium and vitamins.

Blueberry or whole blueberry powder may hold a key for reduced risk breast cancer and for treatment of the diseases. Recent studies insisted that intake of the fruits and the fruit products showed to the improve the survival rate of women with breast cancer.

In estrogen-mediated breast cancer, blueberry-supplemented diet protect women against breast cancer induced by 17β-estradiol (E2)-mediated mammary tumorigenesis(breast cancer)(1) in animals received 5% blueberry diet, either 2 weeks prior to or 12 weeks study.Dr. Ravoori S and the research team at the University of Louisville suggested, the effectiveness of blue berry for treatment of breast cancer may be a result of the exhibition of its phytochemicals reducing mammary tissue proliferation and tumor burden, tumor latency(2).

In fact the intake of berries reduced significantly mammary tumor incidence (10-30%) by suppressing the levels of E(2) to prevent the early onset of E(2) breast cancer(3).
Dr. Aiyer HS and Gupta RC. said, blueberries and other berries promote anti proliferation and apoptosis of breast cancer cell is due its effects in modulating enzymes of estrogen metabolism.

In breast cancer cell lines MCF7 and MDA-MB-231, pterostilbene, a phytochemical found in blueberries, effectively suppressed tumorigenesis and metastasis of cancer stem cells (CSCs) through reduced expressions in promoted(4) and increased tumor cell proliferation of breast cancer(5).

Addition to that, the joint study lead by the Indian Institute of Technology Roorkee showed that pterostilbene not only expressed itself as a effective inducer of apoptosis in human breast in affecting various cellular targets, it also may be a chemopreventive potential based on its stronger anti-proinflammatory cytokines and anti-inflammatory activities against many forms of diseases(6).

In the study of MCF7, Hs578t and MDA-MB-231 breast cancercell lines, pterostilbene suppressed tumor growth and metastasis in MDA-MB-231, the triple-negative breast cancer and Hs578t cells through inhibition of the migratory and invasive potential by blocking the initiate the metastatic process(7).

Further more, the phytochemical also found to inhibit breast cancer regardless of estrogen receptor (ER-α36 positive or negative breast cancer)status by inducing apoptosis(8) and anti-proliferation(9), with or without the execution of cell death in apoptotic cells(8).

The finding of the effectiveness of blueberry and its phytochemical pterostilbene may serve as a cornerstone of pharmaceutical target for further studies as well as a protential medication for treatment of breast disease.

Women who are at high risk of breast cancer such as genetic mutation genes BRCA1 and BRCA2 should drink at least one cup daily and women with breast cancer should drink the juices as much as they can depending to digestive toleration.


All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca


References
(1) Chemopreventive and therapeutic activity of dietary blueberry against estrogen-mediated breast cancer by Jeyabalan J1, Aqil F, Munagala R, Annamalai L, Vadhanam MV, Gupta RC.(PubMed)
(2) Inhibition of estrogen-mediated mammary tumorigenesis by blueberry and black raspberry by Ravoori S1, Vadhanam MV, Aqil F, Gupta RC.(PubMed)
(3) Berries and ellagic acid prevent estrogen-induced mammary tumorigenesis by modulating enzymes of estrogen metabolism by Aiyer HS1, Gupta RC.(PubMed)
(4) Pterostilbene, a bioactive component of blueberries, suppresses the generation of breast cancer stem cells within tumor microenvironment and metastasis via modulating NF-κB/microRNA 448 circuit by Mak KK1, Wu AT, Lee WH, Chang TC, Chiou JF, Wang LS, Wu CH, Huang CY, Shieh YS, Chao TY, Ho CT, Yen GC, Yeh CT.(PubMed)
(5) Twist modulates breast cancer stem cells by transcriptional regulation of CD24 expression by Vesuna F1, Lisok A, Kimble B, Raman V.(PubMed)
(6) Understanding the mode of action of a pterostilbene derivative as anti-inflammatory agent by Nikhil K1, Sharan S1, Palla SR2, Sondhi SM2, Peddinti RK2, Roy P3.(PubMed)
(7) Pterostilbene inhibits triple-negative breast cancer metastasis via inducing microRNA-205 expression and negatively modulates epithelial-to-mesenchymal transition by Su CM1, Lee WH2, Wu AT3, Lin YK4, Wang LS5, Wu CH6, Yeh CT7.(PubMed)
(8) Estrogen receptor-α36 is involved in pterostilbene-induced apoptosis and anti-proliferation in in vitro and in vivobreast cancer by Pan C1, Hu Y2, Li J3, Wang Z4, Huang J5, Zhang S1, Ding L5.(PubMed)
(9) Estrogen receptor-α36 is involved in pterostilbene-induced apoptosis and anti-proliferation in in vitro and in vivobreast cancer by Pan C1, Hu Y2, Li J3, Wang Z4, Huang J5, Zhang S1, Ding L5.(PubMed)
(10) Mondor's disease and breast cancer by Catania S1, Zurrida S, Veronesi P, Galimberti V, Bono A, Pluchinotta A.(PubMed)
(11) Mondor's disease and breast cancer by Catania S1, Zurrida S, Veronesi P, Galimberti V, Bono A, Pluchinotta A.(PubMed)
(12) Successful Treatment of a Recalcitrant Mondor's Cord Following Breast Augmentation by Shah NA1, Gryskiewicz J2, Crutchfield CE 3rd2.(PubMed)
(13) Mondor Disease Treatment & Management by Author: Robert A Schwartz, MD, MPH; Chief Editor: Dirk M Elston, MD(Netscape)

Most Common Diseases of 50plus: Pulmonary vascular disease(Respiratory disease): Pulmonary veno-occlusive disease The Diagnosis

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

                           Respiratory Disease

Respiratory Disease is defined as medical conditions, affecting the breathing organ and tissues including Inflammatory lung disease, Obstructive lung diseases, Restrictive lung diseases, Respiratory tract infections, trachea, bronchi, bronchioles, alveoli, the nerves and muscles breathing, etc,.

   Pulmonary vascular disease:  Pulmonary veno-occlusive disease 


Pulmonary vascular disease is defined as a condition of blood flow to the lung’s artery is blocked suddenly due to a blood clot somewhere in the body, including pulmonary embolism, chronic thromboembolic disease, pulmonary arterial hypertension, pulmonary veno-occlusive disease, pulmonary arteriovenous malformations, pulmonary edema, etc.

Pulmonary veno-occlusive disease (PVOD) is an extremely rare form of pulmonary hypertension, affecting mostly in children and young adults as a result of a progressive obstruction of small pulmonary veins that leads to elevation in pulmonary vascular resistance and right ventricular failure.

                             The Diagnosis

Patients in the early stage with early pulmonary veno-occlusive disease (PVOD) may experience no symptoms at all, but the progression of diseasse may attributable to pulmonary hypertension and right-sided heart failure supervene(32).
B.1. Noninvasive diagnosis to detect PVOD(33)
A noninvasive diagnostic approach may include
1. Chest high-resolution computed tomographymay be helpful for clinical differential diagnosis of PVOD and PCH
In the study to examine chest HRCT images for four patients with idiopathic pulmonary arterial hypertension (IPAH), three patients with PVOD and three patients with PCH, and to evaluate pulmonary vascular casts of lung tissues obtained from those patients at lung transplantation or autopsy, found that
Measurement of the sizes of centrilobular GGOs in HRCT is a simple and useful method for clinical differential diagnosis of PVOD and PCH(34).
2. Arterial blood gas analysis(ABG)
The aim of the blood withdrawn from an artery, involving puncturing an artery with a thin needle and syringe is to determine the pH of the blood, the partial pressure of carbon dioxide and oxygen, the bicarbonate level and gas exchange which reflect gas exchange across the alveolar-capillary membrane(35).
3. Pulmonary function tests (PFT)
It is a complete evaluation of the respiratory system including patient history, physical examinations, chest x-ray examinations, arterial blood gas analysis, and tests of pulmonary function(36).
4. Bronchoalveolar lavage
Bronchoalveolar lavage has a well established role in the diagnosis of pulmonary infections, particularly those due to opportunistic organisms in an immunocompromised host with an aim to assess a number of pulmonary components of whchi may be useful in this regard, particularly if combined with new methods for examining inflammatory responses, such as those utilising the polymerase chain reaction to assess cellular expression for inflammatory cytokines and growth factors.(37).
5. Transthoracic Echocardiography
Transthoracic echocardiography is an important initial non-invasive diagnostic tool with aim to evaluate patients in whom pulmonary hypertension is suspected, according to the ACCF/AHA 2009 Expert Consensus Document on Pulmonary Hypertension(38).
6. Flow cytometry
Pulmonary arterial hypertension (PAH) and pulmonary veno-occlusive disease (PVOD) both display occlusive remodeling of the pulmonary vasculature responsible for increased pulmonary vascular resistances. Cytotoxic T (CTL), natural killer (NK), and natural killer T (NKT) cells play a critical role in vascular remodeling in different physiological and pathological conditions. According to study, a
decrease in GNLY demethylation in the gDNA extracted from peripheral blood mononuclear cells and explanted lungs was found specifically in PVOD but not in PAH. This was associated with a decrease in populations and subpopulations of CTL and NKT and an increase of NK populations. Despite the reduced granulysin-containing cells in patients with PVOD, GNLY serum levels were higher, suggesting these cells were wasting their content. Furthermore, the increase of GNLY concentration in the serum of PVOD was significantly higher than in patients with PAH(39).
B.2. Surgical biopsy
Since surgical biopsy represents a high-risk procedure in these patients, it is contraindicated. lung biopsy or pathologic examination of pulmonary explants or postmortem lung samples. However, lung biopsy is hazardous in patients with severe pulmonary hypertension, and there is a need for noninvasive diagnostic tools in this patient population. Patients with PVOD may be refractory to pulmonary arterial hypertension (PAH)-specific therapy and may even deteriorate with it. It is important to identify such patients as soon as possible, because they should be treated cautiously and considered for lung transplantation if eligible(39).

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Sources
(32) http://emedicine.medscape.com/article/1464015-clinical#a0256
(33) http://www.ncbi.nlm.nih.gov/pubmed/21510732
(34) http://www.ncbi.nlm.nih.gov/pubmed/23312620
(35) http://en.wikipedia.org/wiki/Arterial_blood_gas
(36) http://en.wikipedia.org/wiki/Pulmonary_function_testing
(37) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1029733/
(38) http://content.onlinejacc.org/article.aspx?articleid=1139633
(39) http://www.atsjournals.org/doi/abs

Friday, April 29, 2016

Most Common Disease of 50plus: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Rheumatoid Arthritis: Acupuncture

Kyle J. Norton (Scholar)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed. A major restriction of joint movement range was frequent in the shoulder but uncommon in other joints(1).

Types of Musculo-Skeletal disorders in elder(2)

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia



                                                      Rheumatoid Arthritis

Rheumatoid Arthritis is defined a chronic disorder as a result of inflammation, affecting mostly the flexible (synovial) joints and tissues and organs in the body. The disease affects more women than men and generally occurs after the ages of 40, causing diminished quality of life of many elders(1). According to CDC, Musculoskeletal disorders (MSDs) affects over 52 millions of adults in the US alone, including 294,000 children under age 18 with some form of arthritis or rheumatic conditions(2). Rheumatoid Arthritis can induced bone loss through elevating bone resorption without increasing bone formation(4). A cross-sectional population-based study of 1042 patients with rheumatoid arthritis showed that RA patients had an increased risk of death from various causes(4a).



                            The Treatment



B. Treatment in herbal and traditional Chinese medicine
B.7. Other essential alternative medicine treatment
2. Acupuncture
The most oldest form of medical treatment in traditional Chinese medicine has been known for its function in relief pain(383,313) and functional limitation(384,314) for chronic patient, including patient with moderate or severe chronic pain(383,313).
The Cochrane Field of Rehabilitation and Related Therapies and the Cochrane Musculoskeletal Review suggests the effectiveness of acupuncture as a rehabilitation of an adjunct therapy for the symptomatic treatment of rheumatoid arthritis showed to reduce symptomatic knee pain in patients with RA 24 hours and 4 months post treatment(315). According to Dr. Wang C and the research team at the Tufts Medical Center and Tufts University School of Medicine, acupuncture showed to decrease pain, significant reduced morning stiffness and inflammatory markers in comparison to controls in patients with rheumatoid arthritis(316).In a total of 80 eligible patients, 36 patients with mean age of 58 study, electroacupuncture (EA) and traditional Chinese acupuncture (TCA) significantly reduced tender joints and improved physician's and patients global score but large scale trial are recommended in orderto clarify the existing evidence base on acupuncture for RA.(317).
In the discuss of the imbalance between T-helper 17 (Th17) cells and regulatory T (Treg) cells induced rheumatoid arthritis, use of electroacupuncture (EA) not only restores the balance of Th17/Treg cell but also expresses its anti-inflammatory effects through educed paw volumes, arthritis scores and inflammation scores(319) in collagen-induced arthritis (autoimmune disease ) rats(320).


In fact, poor quality of studies and conflicting evidence exists in placebo-controlled trials, in some cases are also found to accompany with certain inconsistency of its efficacy(318).

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer recommended by Kyle J. Norton

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

References
(1) 8 Areas of Age-Related Change(NIH)
(2) Arthritis-Related Statistics(CDC)
(3) Valgus deformities of the feet and characteristics of gait in patients who have rheumatoid arthritis by Keenan MA1, Peabody TD, Gronley JK, Perry J.(PubMed)
(4) Serum Sclerostin Level Among Egyptian Rheumatoid Arthritis Patients: Relation to Disease Activity ,Bone Mineral Density and Radiological Grading by Mehaney DA, Eissa M, Anwar S, El-Din SF(PubMed)
(4a) Death rates and causes of death in patients with rheumatoid arthritis: a population-based study by Sihvonen S1, Korpela M, Laippala P, Mustonen J, Pasternack A(PubMed)

(313)
(314)
(315) Acupuncture and electroacupuncture for the treatment of rheumatoid arthritis by Casimiro L1, Barnsley L, Brosseau L, Milne S, Robinson VA, Tugwell P, Wells G.(PubMed)
(316) Acupuncture for pain relief in patients with rheumatoid arthritis: a systematic review by Wang C1, de Pablo P, Chen X, Schmid C, McAlindon T.(PubMed)
(317)Acupuncture in the treatment of rheumatoid arthritis: a double-blind controlled pilot study.
Tam LS1, Leung PC, Li TK, Zhang L, Li EK.(PubMed)
(318) A pilot study of acupuncture as adjunctive treatment of rheumatoid arthritis by Zanette Sde A1, Born IG, Brenol JC, Xavier RM.(PubMed)

Most Common Diseases of 50plus: Pulmonary vascular disease(Respiratory disease): Pulmonary veno-occlusive disease - The Misdiagnosis

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

                           Respiratory Disease

Respiratory Disease is defined as medical conditions, affecting the breathing organ and tissues including Inflammatory lung disease, Obstructive lung diseases, Restrictive lung diseases, Respiratory tract infections, trachea, bronchi, bronchioles, alveoli, the nerves and muscles breathing, etc,.

   Pulmonary vascular disease:  Pulmonary veno-occlusive disease 


Pulmonary vascular disease is defined as a condition of blood flow to the lung’s artery is blocked suddenly due to a blood clot somewhere in the body, including pulmonary embolism, chronic thromboembolic disease, pulmonary arterial hypertension, pulmonary veno-occlusive disease, pulmonary arteriovenous malformations, pulmonary edema, etc.

Pulmonary veno-occlusive disease (PVOD) is an extremely rare form of pulmonary hypertension, affecting mostly in children and young adults as a result of a progressive obstruction of small pulmonary veins that leads to elevation in pulmonary vascular resistance and right ventricular failure.

                             The Misdiagnosis

PVOD is an underdiagnosed and commonly misdiagnosed cause of pulmonary hypertension, which may present with a failure to respond to medical therapy. Further studies on PVOD may help confirm whether a change in its classification as a type of PAH is necessary(29). Other study reported a case of a 27-yr-old female with a 6-month diagnosis of idiopathic pulmonary arterial hypertension (PAH) confirmed elsewhere was referred to our centre with worsening dyspnoea. On examination, the patient had low systemic oxygen saturation despite high oxygen flow and reduced exercise capacity. Haemodynamics were indicative of severe pre-capillary PAH. High-resolution computed tomography revealed diffuse ground-glass opacity with thickening interlobular septa, and haemosiderin-laden macrophages were identified by bronchoalveolar lavage. Based on clinical and diagnostic findings, the patient was re-diagnosed with pulmonary veno-occlusive disease (PVOD)(30). Also, there is a review of cases of 14 patients with clinically diagnosed PAH who had failed to respond to medical therapy and had lung tissue available from autopsy or explant. Control samples (n = 6) were obtained from lungs explanted for other causes, and a previous transthoracic echocardiogram excluded pulmonary hypertension(31). 

The CurableSmoothie of Sweet Potato, Tomato, Orange and Blueberry Juice for Prevention and Treatment of Pseudoangiomatous stromal hyperplasia, a benign breast tumor

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for prevention and treatment of Pseudoangiomatous stromal hyperplasia, a benign breast tumor
Yield: 2 servings (about 8 ounces each)
1/ 2 sweet potato
1/2 orange
1/2 tomato
1 cup blueberry juice

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately

The finding of a natural source for treatment of Pseudoangiomatous stromal hyperplasia has been running into many obstacles, many ingredients showed initially with promising result in animal studies have not produced same potentials in large sample size and mutli centers human trials.

Pseudoangiomatous stromal hyperplasia (PASH) is a benign breast disease of mammary stromal
tumor caused by multipotent stromal cells proliferated lesion of the breast, frequently found in a microscopic incidental in breast biopsies performed for benign or malignant disease(7) According to surgical excision may be necessary for larger lesions and in women with Pseudoangiomatous stromal hyperplasia are at an increased risk for developing breast cancer(8).

Women with benign breast disease(BBD) are found to have lower antioxidant status, probably to compensate for this elevated free radical production(3)

According to the, dietary supplement "Karinat" containing beta-carotene 2.5 mg, alpha-tocopherol 5 mg, ascorbic acid 30 mg and garlic powder 150 mg per one tablet in a total of 66 patients twice a day during 6 months exhibited anti benign breast disease up to 75.8% in comparison to placebo(2).

According to the Chinese University of Hong Kong, Intakes of vitamin E and individual carotenoids may associate to reduce risk proliferative BBD(4), particular in carotenoids intake in BBD of adolescent girls(5).

Dr. Ramaswamy G and Dr. Krishnamoorthy L. said, "Serum ascorbate levels were significantly lower in patients with benign diseases of the breast and cervix than in controls"(6).

The effectiveness of Sweet Potato(Vitamin E), Tomato(Vitamin A) and Orange (Ascorbic Acid or Vitamin C )  may serve as cornerstones of pharmaceutical target for further studies in production of a potential medication for for Reduced Risk and treatment of Granular cell tumor (GCT) of the breast, a benign disease of the breast with little or no adverse effects.

Adding organic blueberry juice to the smoothie may also ameliorate the risk of breast cancer induced by Pseudoangiomatous stromal hyperplasia, according to recent studies insisted that intake of the fruits and the fruit products showed to the improve the survival rate of women with breast cancer(9).
Women who are at increased risk of Pseudoangiomatous stromal hyperplasia of the breast may drink at least one serving daily and women with Pseudoangiomatous stromal hyperplasia of the breast may drink as much as they can, depending to the digestive toleration.
Life style and dietary patter change are recommended

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca


References
(1) Benign breast disease and the risk of breast cancer in the next 15 years by Socolov D, Anghelache I, Ilea C, Socolov R, Carauleanu A.(PubMed)
(2) [Study of an antioxidant dietary supplement "Karinat" in patients with benign breast disease].
[Article in Russian] by Bespalov VG, Barash NIu, Ivanova OA, Krzhivitskiĭ PI, Semiglazov VF, Aleksandrov VA, Sobenin NA, Orekhov AN.(PubMed)
(3) Lipid peroxidation and antioxidant status in blood and tissue of malignant breast tumor and benign breast disease by Gönenç A1, Erten D, Aslan S, Akinci M, Simşek B, Torun M.(PubMed)
(4) Intakes of fat and micronutrients between ages 13 and 18 years and the incidence of proliferative benign breast disease. by Su X1, Boeke CE, Collins LC, Baer HJ, Willett WC, Schnitt SJ, Connolly JL, Rosner B, Colditz GA, Tamimi RM.(PubMed)
(5) Adolescent carotenoid intake and benign breast disease by Boeke CE1, Tamimi RM2, Berkey CS3, Colditz GA4, Eliassen AH2, Malspeis S5, Willett WC6, Frazier AL7.(PubMed)
(6) Serum carotene, vitamin A, and vitamin C levels in breast cancer and cancer of the uterine cervix. by Ramaswamy G1, Krishnamoorthy L.(PubMed)
(7) Pseudoangiomatous stromal hyperplasia (PASH). A mammary stromal tumor with myofibroblastic differentiation by Powell CM1, Cranor ML, Rosen PP.(PubMed)
(8) Pseudoangiomatous Stromal Hyperplasia of the Breast: Multimodality Review With Pathologic Correlation by Raj SD1, Sahani VG1, Adrada BE2, Scoggins ME2, Albarracin CT3, Woodtichartpreecha P2, Posleman Monetto FE2, Whitman GJ4. by (PubMed)
(9) The Curablesmoothie: The Blueberry Smoothie for Reduced Risk and Treatment of Breast Cancer by Kyle J. Norton

Most Common Disease of50plus: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Rheumatoid Arthritis: The miracle of Olive oil

Kyle J. Norton (Scholar)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed. A major restriction of joint movement range was frequent in the shoulder but uncommon in other joints(1).

Types of Musculo-Skeletal disorders in elder(2)

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia



                                                      Rheumatoid Arthritis

Rheumatoid Arthritis is defined a chronic disorder as a result of inflammation, affecting mostly the flexible (synovial) joints and tissues and organs in the body. The disease affects more women than men and generally occurs after the ages of 40, causing diminished quality of life of many elders(1). According to CDC, Musculoskeletal disorders (MSDs) affects over 52 millions of adults in the US alone, including 294,000 children under age 18 with some form of arthritis or rheumatic conditions(2). Rheumatoid Arthritis can induced bone loss through elevating bone resorption without increasing bone formation(4). A cross-sectional population-based study of 1042 patients with rheumatoid arthritis showed that RA patients had an increased risk of death from various causes(4a).



                            The Treatment



B. Treatment in herbal and traditional Chinese medicine
3. The miracle of Olive oil
Olive is belongs to the the family Oleaceae, native to the coastal areas of the eastern Mediterranean Basin and south end of the Caspian Sea. Its fruit, is also called the olive and the source of olive oil.

Olive Oil: Fat Content
1. Saturated fats
a. Palmitic acid
b. Stearic acid
c. Arachidic acid
d. ehenic acid
e. Myristic acid
f. Lignoceric acid
2. Unsaturated fat3. Monounsaturated fats
a. Oleic acid
b. Palmitoleic acid
3. Polyunsaturated fats
a. Linoleic acid
b. Linolenic acid

Monounsaturated fatty acids found abundantly in extra virgin olive oil has found to inhibit proinflammatory cytokines in inducing the decreases lubricin expression and predisposes to cartilage degeneration(247). Intake of olive oil, according to the University of Athens Medical School and University of Seville, showed to reduce risk of risk of rheumatoid arthritis (RA) due to the effects of n-3 fatty acids through the antioxiant activity(248) as well as preventing inflammatory response and cartilage matrix degradation in murine collagen-induced rheumatoid arthritis(249), respectively.
Furthermore, in animal models of acute inflammation and rheumatoid arthritis, hydroxytyrosol, a phytochemical found in virgin olive oil, a primary source of fat in the Mediterranean diet, inhibited significant impact on chronic inflammation and acute inflammatory processes, through its antioxidant and anti-inflammatory properties, recent study suggested.(250).
In deed, dr. González Cernadas L and the research team at the Unidad de Fisioterapia Basada en la Evidencia del Departamento de Fisioterapia de la Universidad de A Coruña said," some dietetic elements (polyunsaturated fatty acids, mediterranean diet and antioxidants) with inflammatory markers reduction and oxidative stress inhibition have anti-inflammatory effects and decrease AR disease activity"(251).

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer recommended by Kyle J. Norton

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

References

(247) Extra-virgin olive oil diet and mild physical activity prevent cartilage degeneration in an osteoarthritis model: an in vivo and in vitro study on lubricin expression by Musumeci G, Trovato FM, Pichler K, Weinberg AM, Loreto C, Castrogiovanni P.(PubMed)
(248) Dietary factors in relation to rheumatoid arthritis: a role for olive oil and cooked vegetables? by Linos A1, Kaklamani VG, Kaklamani E, Koumantaki Y, Giziaki E, Papazoglou S, Mantzoros CS.(PubMed)
(249) Dietary extra-virgin olive oil prevents inflammatory response and cartilage matrix degradation in murine collagen-induced arthritis. by Rosillo MA1, Sánchez-Hidalgo M, Sánchez-Fidalgo S, Aparicio-Soto M, Villegas I, Alarcón-de-la-Lastra C.(PubMed)
(250) Protective effects of hydroxytyrosol-supplemented refined olive oil in animal models of acute inflammation andrheumatoid arthritis by Silva S1, Sepodes B2, Rocha J2, Direito R2, Fernandes A2, Brites D2, Freitas M3, Fernandes E3, Bronze MR1, Figueira ME4.(PubMed)
(251) [Importance of nutritional treatment in the inflammatory process of rheumatoid arthritis patients; a review].[Article in Spanish] by González Cernadas L1, Rodríguez-Romero B2, Carballo-Costa L2.(PubMed)

Thursday, April 28, 2016

Most Common Disease of50plus: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Rheumatoid Arthritis: The Salmon calcitonin

Kyle J. Norton (Scholar)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed. A major restriction of joint movement range was frequent in the shoulder but uncommon in other joints(1).

Types of Musculo-Skeletal disorders in elder(2)

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia



                                                      Rheumatoid Arthritis

Rheumatoid Arthritis is defined a chronic disorder as a result of inflammation, affecting mostly the flexible (synovial) joints and tissues and organs in the body. The disease affects more women than men and generally occurs after the ages of 40, causing diminished quality of life of many elders(1). According to CDC, Musculoskeletal disorders (MSDs) affects over 52 millions of adults in the US alone, including 294,000 children under age 18 with some form of arthritis or rheumatic conditions(2). Rheumatoid Arthritis can induced bone loss through elevating bone resorption without increasing bone formation(4). A cross-sectional population-based study of 1042 patients with rheumatoid arthritis showed that RA patients had an increased risk of death from various causes(4a).



                            The Treatment

B. Treatment in herbal and traditional Chinese medicine
2. The miracle Salmon calcitonin
Salmon, is a highly nutrition with best source of Omega 3 fatty acids found in fish for human consumption born in fresh water, migrate to the deep ocean, then travel thousands of miles in the deep sea cold water throughout their life cycle and within to five years returning to the exacted location where they were born to reproduce and die.

Nutrients
1. Protein
2. Omega-3 fatty acids
3. B vitamins
4. Vitamin D
5. Astaxanthin
is a potent antioxidant that stimulates the development of healthy fish nervous systems and enhances the fish's fertility and growth rate.
6. Selenium
7. Tryptophan
8. Magnesium
9. Phosphorus
10. Etc.

Intake of salmon calcitonin, a hormone extract from salmon or a synthetic polypeptide of the same sequence found in salmon, has shown to attenuate the pathogenesis of rheumatoid arthritis (RA, through reduced expression of a key of (orphan nuclear receptor, NR4A2) redulator and potential biomarker for inflammation(243). Dr. Tascioglu F and the research team at the Osmangazi University Faculty of Medicine, said." alendronate and intranasal salmon calcitonin (sCT) treatments,...produced significantly greater increases in the femoral neck BMD and greater decreases in bone turnover than intranasal sCT in RA patients receiving low dose glucocorticoids"(244). Furthermore, according to the multicenter study of 32 women with RA, intranasal salmon calcitonin (sCT) prevented bone loss at the proximal femur in patients with active RA induced by intake of low dose glucocorticoids for 12 months(245).

Salmon proteoglycan prepared from salmon nasal cartilage under nondenaturing conditions showed to improve autoimmune disease caused by chronic inflammation of connective tissues, through modulating immune response of splenocytes to CII stimulation and local production inflammatory cytokines and chemokines in the joints, the research lead by Dr. Yoshimura S. suggested.(246).

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer recommended by Kyle J. Norton

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

References

(243) An intra-articular salmon calcitonin-based nanocomplex reduces experimental inflammatory arthritis by Ryan SM1, McMorrow J, Umerska A, Patel HB, Kornerup KN, Tajber L, Murphy EP, Perretti M, Corrigan OI, Brayden DJ.(PubMed)
(244) The treatment of osteoporosis in patients with rheumatoid arthritis receiving glucocorticoids: a comparison of alendronate and intranasal salmon calcitonin by Tascioglu F1, Colak O, Armagan O, Alatas O, Oner C.(PubMed)
(245) Is continuous intranasal salmon calcitonin effective in treating axial bone loss in patients with active rheumatoid arthritis receiving low dose glucocorticoid therapy? by Kotaniemi A1, Piirainen H, Paimela L, Leirisalo-Repo M, Uoti-Reilama K, Lahdentausta P, Ruotsalainen P, Kataja M, Väisänen E, Kurki P.(PubMed)
(246) Attenuation of collagen-induced arthritis in mice by salmon proteoglycan by Yoshimura S1, Asano K1, Nakane A1.(PubMed)

The Curablesmoothie of Green Tea, Grape and Ginger for Reduced Risk and Treatment of Nephritis

Kyle J. Norton(Scholar)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for reduced risk and treatment of Nephritis

Yield: 2 serving (about 8 ounce each)
3/4 cup pomegranate
3/4 cup of cherries
1 cup green tea drink 1 cup green tea drink (Make from 4 grams(2 tea bags) of green tea, a slice of ginger and a cup of hot water lipped for 5 minutes, and set aside for cooling to room temperature)


1. Place the pomegranate, cherries, and green tea, in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed. Add more green tea drink if needed
3. Serve immediately

Nephritis is a condition of inflammation of kidneys

Many suggestions that pumpkin seeds used in conjunction with green tea may be a potential combination for reduced risk and treatment of Nephritis. due to the phytochemicals of catechins in green tea(1). 
Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years used in traditional Chinese medicien for treatment of variety of diseases, including cancers and heart diseases.
According to the Graduate Institute of Medical Sciences, National Defense Medical Center, phytochemical Epigallocatechin-3-gallate isolated from green tea inhibited nephritis through it relation of proinflammatory cytokines and enhanced antioxidant signaling pathway(1).
The major chemical constituent EGCG also prevented cisplatin-induced nephrotoxicity and reduced due to over expression of NF-kappaB, the inflammatory pathway(2).
The Shanghai Tenth People's Hospital of Tongji University study in the evaluation of the effects of EGCG in animal with glomerulonephritis said, " EGCG pretreatment period. Importantly, mortality and renal dysfunction were significantly attenuated even when the polyphenol treatment was initiated 1 week after the onset of GN. Thus, EGCG reversed the progression of immune-mediated GN in mice by targeting redox and inflammatory pathways"(3).

Resveratrol, found abundantly in grape, blueberry and peanut  is a phytochemical in the class of Stilbenoids, exhibited anti inflammatory diseases, including the Nephritis, through attenuated on 
proteinuria, hypoalbuminemia and hyperlipidemia(4). According to University of Yamanashi, the phytochemicals also expressed inhibition of pro inflammatory cytokines in the NF-kappaB pathway via antioxidant and oxidative stress effects(5).

Ginger (Zingiber officinale) or ginger root is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil. It has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc. According to the Dr. Nassan M and Dr. Mohamed EH ginger expressed strongly antimicrobial and immuno modulating effects on certain pathogenic microorganisms in ameliorated acute hematogenous pyelonephritis in animal model(6).

The effectiveness of Green Tea, Grape and Ginger may serve as cornerstones of pharmaceutical target for further studies in production of a potential medication for Reduced Risk of Nephritis with little or no adverse effects.

People who are at increased risk of Nephritis due to family history, weaken immunity.... should drink 1 serving daily and people with Nephritis should drink as much as they can, depending to digestive toleration.
Life style and diet pattern changed are recommended

All Forms of Arthritis are Curable

Ovarian Cysts And PCOS Elimination


References
(1) Epigallocatechin-3-gallate prevents lupus nephritis development in mice via enhancing the Nrf2 antioxidant pathway and inhibiting NLRP3 inflammasome activation by Tsai PY1, Ka SM, Chang JM, Chen HC, Shui HA, Li CY, Hua KF, Chang WL, Huang JJ, Yang SS, Chen A.(PubMed)
(2) Epigallocatechin-3-gallate activates Nrf2/HO-1 signaling pathway in cisplatin-induced nephrotoxicity in rats by Sahin K1, Tuzcu M, Gencoglu H, Dogukan A, Timurkan M, Sahin N, Aslan A, Kucuk O.(PubMed)
(3) The green tea polyphenol (-)-epigallocatechin-3-gallate ameliorates experimental immune-mediated glomerulonephritis by Peng A1, Ye T, Rakheja D, Tu Y, Wang T, Du Y, Zhou JK, Vaziri ND, Hu Z, Mohan C, Zhou XJ.(PubMed)
(4) Inhibitory effect of resveratrol on proteinuria, hypoalbuminemia and hyperlipidemia in nephritic rats by Nihei T1, Miura Y, Yagasaki K.(PubMed)
(5) Enhancement of NF-kappaB activity by resveratrol in cytokine-exposed mesangial cells by Uchida Y1, Yamazaki H, Watanabe S, Hayakawa K, Meng Y, Hiramatsu N, Kasai A, Yamauchi K, Yao J, Kitamura M.(PubMed)
(6) Immunopathological and antimicrobial effect of black pepper, ginger and thyme extracts on experimental model of acute hematogenous pyelonephritis in albino rats by Nassan MA1, Mohamed EH2.(PubMed)

Most Common Diseases of 50plus: Pulmonary vascular disease(Respiratory disease): Pulmonary veno-occlusive disease The Complications

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

                           Respiratory Disease

Respiratory Disease is defined as medical conditions, affecting the breathing organ and tissues including Inflammatory lung disease, Obstructive lung diseases, Restrictive lung diseases, Respiratory tract infections, trachea, bronchi, bronchioles, alveoli, the nerves and muscles breathing, etc,.

   Pulmonary vascular disease:  Pulmonary veno-occlusive disease 


Pulmonary vascular disease is defined as a condition of blood flow to the lung’s artery is blocked suddenly due to a blood clot somewhere in the body, including pulmonary embolism, chronic thromboembolic disease, pulmonary arterial hypertension, pulmonary veno-occlusive disease, pulmonary arteriovenous malformations, pulmonary edema, etc.

Pulmonary veno-occlusive disease (PVOD) is an extremely rare form of pulmonary hypertension, affecting mostly in children and young adults as a result of a progressive obstruction of small pulmonary veins that leads to elevation in pulmonary vascular resistance and right ventricular failure.

                     The Complications

1. Pulmonary vascular resistance, right heart failure and premature death
PVOD is characterised by progressive obstruction of small pulmonary veins and venules that leads to increased pulmonary vascular resistance, right heart failure and premature death, according to the study by université Paris-Sud, 94276 Kremlin-Bicêtre(19).
2. Occult alveolar haemorrhage
Occult alveolar haemorrhage is a common feature of pulmonary veno-occlusive disease. Detecting occult alveolar haemorrhage may be of interest in the diagnostic approach of pulmonary veno-occlusive disease, according to the study by Université Paris-Sud, Clamart(20).
3. Other complications
The most frequent CT-findings in pulmonary veno-occlusive disease were the following: ground glass opacity with poorly defined nodular opacities (73%), septal lines (93%), and adenopathy (80%). Pericardial (60%) and pleural effusions (27%) were also noted. Other parenchymal findings were unusual, according to the study by Hôpitaux de Paris, Université Paris Sud(21).

Most Common Disease of50plus: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Rheumatoid Arthritis: The Diet modification

Kyle J. Norton (Scholar)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed. A major restriction of joint movement range was frequent in the shoulder but uncommon in other joints(1).

Types of Musculo-Skeletal disorders in elder(2)

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia



                                                      Rheumatoid Arthritis

Rheumatoid Arthritis is defined a chronic disorder as a result of inflammation, affecting mostly the flexible (synovial) joints and tissues and organs in the body. The disease affects more women than men and generally occurs after the ages of 40, causing diminished quality of life of many elders(1). According to CDC, Musculoskeletal disorders (MSDs) affects over 52 millions of adults in the US alone, including 294,000 children under age 18 with some form of arthritis or rheumatic conditions(2). Rheumatoid Arthritis can induced bone loss through elevating bone resorption without increasing bone formation(4). A cross-sectional population-based study of 1042 patients with rheumatoid arthritis showed that RA patients had an increased risk of death from various causes(4a).


                               The Treatment



B. Treatment in herbal and traditional Chinese medicine
B.3. Diet modification according herbal and TCM medicine specialist

1. Top foods to reduce risk of inflammation
Foods with anti pro inflammatory cytokines can be helpful to prevent and to protect against early
onset of rheumatoid arthritis. "Low grade inflammation has been found to play a pathophysiological role in RA" Dr. Jeppesen J. said (225) as the proinflammatory cytokines may affect synoviocyte proliferation caused by elevated interleukin-21 (IL-21) IL-21-induced proliferation and secretion of TNF-α and IL-6(226).

1. 1. Garlic
Garlic (Allium sativum) is a species in the onion genus, belongings to family Amaryllidaceae, native to central Asia, used popularly in traditional and Chinese medicine to treat common cold and flu(228), strengthen immunity(228), etc....The clinical trial of alisate--a garlic preparation produced in Russia showed the effectiveness of alisate used compunction with other and monotherapy in reduced symptoms of RA with little side effects(227). Dr. Majewski M. said" aged garlic extract (AGE), have a clear and significant biological effect in immune system improvement,...Clinically,garlic has been evaluated for a number of purposes, including treatment of .....rheumatoid arthritis,..."(228)

1.2. Ginger
Ginger (Zingiber officinale) used in many Eastern culture as a cooking spice is best in the West for its treatment againts morning sickness in early stage of pregnancy. The herbal medicine is also found to relieve pain induced by inflammation due to its effects in inhibited pro inflammatory cytokines(229) of that may be beneficiary as pharmaceutical ingredient for treatment of Rheumatoid arthritis(230) when used in combination with others herbal medicine. DR. Al-Nahain A and the research team at the University of Development Alternative said, "(Ginger) not only can provide symptomatic relief but also may provide total relief from RA by stopping RA-induced bone destruction"(231).

1.3. Turmeric
Turmeric is a perennial plant used as spice in Indian and as herbal medicine for strengthening the overall energy of the body, relieving gas, dispelling worms, improving digestion, regulating menstruation, dissolving gallstones, etc.(232) may be a potential candidate for treatment of rheumatoid arthritis due of its phytochemical curcumin imilar to methotrexate(233). Dr. Ramadan G and Dr. El-Menshawy O. said, "mixture of ginger and turmeric rhizomes powder (1 : 1) suspended in distilled water (GTaq) in alleviating both articular and extra-articular manifestations in rat adjuvant-induced arthritis (AIA),.....may be effective against RA severity and complications"(234), probably due to the mixture anti-inflammatory and anti-oxidant properties(235).

1.4. Green tea
Green tea , a precious drink in traditional Chinese and many culture in Southeast Asia cultures used exceptional in socialization for more than 4000 thousand years has been found to consist the property of suppressed autoimmune arthritis(238) through its phytochemical epigallocatechin-3-Gallate
(EGCG) in upregulation of the Nrf-2 antioxidant pathway in -mediated immunoregulation and ameliorated experimental arthritis in animal study(236).
Dr. Riegsecker S and the research team at the University of Toledo said," (The) potential benefits of green tea polyphenol EGCG in the prevention and treatment of vascular inflammation in rheumatoid arthritis,.........., extensive clinical evidence of the 'synovial inflammation-systemic inflammation' link and the benefits of EGCG in regulating cytokine-driven inflammation in the pathogenesis of RA and its CV complication"(237).

1.5. Cooked tomato
Tomato, the edible vegetable is best known for its phytochemical lycopene found in skin for treatment of prostate health(239)(240). According to the University of Kerala, lycopene (all-trans) found in tomato may be a better natural source with increased activity and without side effects in the treatment of anti-inflammatory diseases, in the study on type II collagen induced arthritis in Sprague Dawley rats(241). In a total of 184,643 US women followed in the Nurses' Health Study and Nurses' Health Study II cohorts in 1980-2004 study showed that intake of antioxidants including lycopene, may protect against development of rheumatoid arthritis or systemic lupus erythematosus by combating oxidative stress(242).

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer recommended by Kyle J. Norton

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
References

(225) Low-grade chronic inflammation and vascular damage in patients with rheumatoid arthritis: don't forget "metabolic inflammation" by Jeppesen J.(PubMed)
(226) Interleukin-21 Induces Proliferation and Proinflammatory Cytokine Profile of Fibroblast-like Synoviocytes of Patients with Rheumatoid Arthritis by Xing R1, Yang L1, Jin Y1, Sun L1, Li C1, Li Z2, Zhao J1, Liu X1.(PubMed)
(227) [Garlic effectiveness in rheumatoid arthritis].[Article in Russian] by Denisov LN, Andrianova IV, Timofeeva SS.(PubMed)
(228) Allium sativum: facts and myths regarding human health by Majewski M.(PubMed)
(229) Influence of ginger and cinnamon intake on inflammation and muscle soreness endued by exercise in Iranian female athletes by Mashhadi NS1, Ghiasvand R, Askari G, Feizi A, Hariri M, Darvishi L, Barani A, Taghiyar M, Shiranian A, Hajishafiee M.(PubMed)
(230) Effect of sanhuangwuji powder, anti-rheumatic drugs, and ginger-partitioned acupoint stimulation on the treatment of rheumatoid arthritis with peptic ulcer: a randomized controlled study by Liu D, Guo M, Hu Y, Liu T, Yan J, Luo Y, Yun M, Yang M, Zhang J, Guo L.(PubMed)
(231) Zingiber officinale: A Potential Plant against Rheumatoid Arthritis by Al-Nahain A1, Jahan R2, Rahmatullah M1.(PubMed)
(232) Herbal Medicine: Biomolecular and Clinical Aspects. 2nd edition, Chapter 13Turmeric, the Golden Spice From Traditional Medicine to Modern Medicine by Sahdeo Prasad and Bharat B. Aggarwal(NCBI)
(233) The effect of curcumin and its nanoformulation on adjuvant-induced arthritis in rats by Zheng Z1, Sun Y2, Liu Z1, Zhang M1, Li C1, Cai H3.(PubMed)
(234)Protective effects of ginger-turmeric rhizomes mixture on joint inflammation, atherogenesis, kidney dysfunction and other complications in a rat model of human rheumatoid arthritis by Ramadan G1, El-Menshawy O.(PubMed)
(235) Anti-inflammatory and anti-oxidant properties of Curcuma longa (turmeric) versus Zingiber officinale (ginger) rhizomes in rat adjuvant-induced arthritis by Ramadan G1, Al-Kahtani MA, El-Sayed WM.(PubMed)
(236) Green Tea Epigallocatechin-3-Gallate Suppresses Autoimmune Arthritis Through Indoleamine-2,3-Dioxygenase Expressing Dendritic Cells and the Nuclear Factor, Erythroid 2-Like 2 Antioxidant Pathway by Min SY1, Yan M1, Kim SB2, Ravikumar S3, Kwon SR4, Vanarsa K3, Kim HY5, Davis LS1, Mohan C3.(PubMed)
(237) Potential benefits of green tea polyphenol EGCG in the prevention and treatment of vascular inflammation inrheumatoid arthritis by Riegsecker S1, Wiczynski D, Kaplan MJ, Ahmed S.(PubMed)
(238) Nutraceuticals of anti-inflammatory activity as complementary therapy for rheumatoid arthritis by Al-Okbi SY1.(PubMed)
(239) A Phase II Randomized Trial of Lycopene-Rich Tomato Extract Among Men with High-Grade Prostatic Intraepithelial Neoplasia by Gann PH1, Deaton RJ1, Rueter EE1, van Breemen RB2, Nonn L1, Macias V1, Han M3, Ananthanarayanan V4.(PubMed)
(240) Lycopene/tomato consumption and the risk of prostate cancer: a systematic review and meta-analysis of prospective studies by Chen J1, Song Y, Zhang L.(PubMed)
(241) Anti-inflammatory activity of lycopene isolated from Chlorella marina on type II collagen induced arthritis in Sprague Dawley rats by Renju GL1, Muraleedhara Kurup G, Saritha Kumari CH.(PubMed)
(242) Antioxidant intake and risks of rheumatoid arthritis and systemic lupus erythematosus in women by Costenbader KH1, Kang JH, Karlson EW.(PubMed)

The smoothie of celery, apple and green tea for Hypertensive complication caused by Nutcracker syndrome


Kyle J. Norton(Scholar), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Nutcracker syndrome is a vascular compression of the left renal vein between the superior mesenteric artery (SMA) and aorta, causing increased blood pressure inducing rupture of thin-walled veins to cause accumulation of haematuria. Surgical treatment may be the best option for patients with the syndrome(14)(15).
To reduce the complication of hypertension in induction of accumulation of haematuria, the following smoothie can be helpful.


Blood pressure is the force of blood pushing against the walls of the arteries as the heart pumps out blood. high blood pressure means raising pressure in your heart. If your blood pressure stays high over time it can damage the body in many ways.
Blood pressure medications have undoubtedly prevented many deaths from heart disease in the past 30 years, but also induced many irreversible adverse effects, including kidney damage.

The smoothie for people with Hypertensive complication caused by Nutcracker syndrome
Yield: 2 servings (about 8 ounces each)
3/4 cup celery
3/4 cup of apple with peel
1 cup green tea drink 1 cup green tea drink (Make from 4 grams(2 tea bags) of green tea, a slice of ginger and a cup of hot water lipped for 5 minutes, and set aside for cooling to room temperature)

1. Place the celery, apple with peels, green tea, in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately

Diet rich in fruits and vegetable and reduced intake of red meat, saturated fat and trans fat has shown to attenuated risk of hypertension(1). Recent study showed that celery(2) intake used conjunction with berries(3) and green tea(4) may be the potential drink for prevention and treatment of hypertension.

Celery is a species of Apium graveolens, belongings to the family Apiaceae, cultivated all around the globe as a vegetable. According to Chronic administration of hexanic, methanolic, and aqueous-ethanolic extracts of celery seed effectively exhibited an antihypertensive activity in chronic treatment of elevated BP in tested animals(5).

Dr. Dianat M and the research team at the Ahvaz Jundishapur University of Medical Sciences said," hydro-alcoholic celery leaf extract on systolic blood pressure (SBP), heart rate (HR) and lipid profile in animals' model of hypertension induced by fructose"(6)

3‑n‑butylphthalide (NBP), an phytochemical found in celery seed used in traditional Chinese medicine exhibited significantly antihypertensive and attenuated progression of hypertensive effects through decreased oxidative stress and the expression of pro‑inflammatory cytokines(7).
Apple is the pomaceous fruit of the apple tree, a species of the rose family Rosaceae. It is one of the most widely cultivated tree fruits. With phytochemical flavonoids, apple and its peel inhibited angiotensin converting enzyme (ACE) in promoted the development of high blood pressure, Dr Balasuriya N and Dr. Rupasinghe HP. Suggested(8)According to the Mount Sinai School of Medicine, "Flavonoid (found abundantly in fruits and vegetable)(10) intake has been inversely associated with mortality from coronary heart disease and stroke,..... Lowering blood pressure through increased dietary consumption of dietary antioxidants(such as flavonoid) may decrease the rate of end-organ damage that is secondary to hypertension"(9).

Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Due to its commercial values and health effects, green tea now has been cultivated all over the world in suitable climate.

Epigallocatechin-3-O-gallate (EGCG), the main polyphenol presence in green tea is best known for its antioxidant and anti inflammatory effect. In animal model, the phytochemical exhibited anti hypertensive and progressive activity through reduction of oxidative stress in paraventricular nucleus of hypothalamus (PVN), the Xi'an Jiaotong University Health Science Center study showed(11).

Dr. Yarmolinsky J and the research team at the Federal University of Rio Grande do Sul, suggested that, intake of tea are shown to reduce blood pressure in individuals within prehypertensive and hypertensive ranges in the review of all relevant studies published from 1946 to September 27, 2013.(12).

Furthermore, green tea extract (GTE) inhibited the oxidative stress and ingiotensin (Ang) II induces endothelial dysfunction (ED) causes of hypertension through scavenging of superoxide anion generation, the University of Padova, insisted(13).

People who are at increased risk of hypertension caused by Nutcracker syndrome should drink the juices at least 3 times a day, depending to digestive toleration.
Change of life style and diet pattern are also recommended.

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca


References

(1) Fruit and Vegetable Consumption and the Incidence of Hypertension in Three Prospective Cohort Studies by Borgi L1, Muraki I2, Satija A2, Willett WC2, Rimm EB2, Forman JP2.(PubMed)
(2) The effect of hydro-alcoholic celery (Apiumgraveolens) leaf extract on cardiovascular parameters and lipid profile in animal model of hypertension induced by fructose by Dianat M1, Veisi A1, Ahangarpour A1, Fathi Moghaddam H1.(PubMed)
(3) Flavonoids from fruit and vegetables: a focus on cardiovascular risk factors by Toh JY1, Tan VM, Lim PC, Lim ST, Chong MF.(PubMed)
(4) Decaffeinated green tea extract improves hypertension and insulin resistance in a rat model of metabolic syndrome by Ihm SH1, Jang SW, Kim OR, Chang K, Oak MH, Lee JO, Lim DY, Kim JH.(PubMed)
(5) Antihypertensive effect of celery seed on rat blood pressure in chronic administration by Moghadam MH1, Imenshahidi M, Mohajeri SA.(PubMed)
(6) The effect of hydro-alcoholic celery (Apiumgraveolens) leaf extract on cardiovascular parameters and lipid profile in animal model of hypertension induced by fructose by Dianat M1, Veisi A1, Ahangarpour A1, Fathi Moghaddam H1.(PubMed)
(7) Protective effect of 3-n-butylphthalide against hypertensive nephropathy in spontaneously hypertensive rats by Zhu J1, Zhang Y1, Yang C1.(PubMed)
(8) Antihypertensive properties of flavonoid-rich apple peel extract by Balasuriya N1, Rupasinghe HP.(PubMed)
(9) Dietary flavonoids and hypertension: is there a link? by Moline J1, Bukharovich IF, Wolff MS, Phillips R.(PubMed)
(10) Antihypertensive effects of the flavonoid quercetin by Perez-Vizcaino F1, Duarte J, Jimenez R, Santos-Buelga C, Osuna A.(PubMed)
(11) Paraventricular Nucleus Infusion of Epigallocatechin-3-O-Gallate Improves Renovascular Hypertension by Yi QY1, Qi J, Yu XJ, Li HB, Zhang Y, Su Q, Shi T, Zhang DM, Guo J, Feng ZP, Wang ML, Zhu GQ, Liu JJ, Shi XL, Kang YM.(PubMed)
(12) Effect of tea on blood pressure for secondary prevention of cardiovascular disease: a systematic review and meta-analysis of randomized controlled trials by Yarmolinsky J1, Gon G2, Edwards P2.(PubMed)
(13) Prevention of hypertension, cardiovascular damage and endothelial dysfunction with green tea extracts by Antonello M1, Montemurro D, Bolognesi M, Di Pascoli M, Piva A, Grego F, Sticchi D, Giuliani L, Garbisa S, Rossi GP.(PubMed)
(14) Surgical treatment of posterior nutcracker syndrome presented with hyperaldosteronism by Deser SB1, Onem K2, Demirag MK3, Buyukalpelli R2.(PubMed)
(15) Laparoscopic Extravascular Stent Placement for Nutcracker Syndrome: A Report of 13 Cases by Wang SZ1, Zhang WX1, Meng QJ1, Zhang XP1, Wei JX1, Qiao BP1.(PubMed)