Gingivitis is a common and mild form of periodontal disease caused by inflammation of the gingiva, leading to symptoms of irritation, redness, and swelling of the gum that lines the base of the teeth.
Gingivitis dental plaques formed around the base of the teeth are sticky biofilm of bacteria associated with the interaction of the food intake and bacteria in the mouth. Over time, if untreated, the condition can lead to periodontitis and advanced periodontitis.
At this early stage, the bone and connective tissue that hold the teeth in place are not yet affected. The problems can be reversed by more frequent and proper brushing and flossing.
The most common cause of gingivitis is poor hygiene. Epidemiologically, risk factors induce the onset of gingivitis are smoking or chewing tobacco. diabetes and long-term use of certain medication including oral contraceptives, steroids, anticonvulsants, calcium channel blockers.
Some people under the treatment of chemotherapy may also experience symptoms of gingivitis.
Periodontitis is a severe stage of gingivitis that damages the soft tissue and destroys the bone that supports your teeth, leading to teeth loosen or tooth loss.
Periodontitis can be classified into
* Chronic periodontitis is caused by plaque buildup and involves the slow deterioration of the gums and bone and loss of teeth if not treated. The condition is a common condition that affects mostly adults.
* Aggressive periodontitis found mostly in childhood or early adulthood. The condition is rare that causes rapid progression of bone and tooth loss if untreated.
* Necrotizing periodontal disease is a severe infection that causes the death of gum tissue, tooth ligaments and supporting bone.
Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean. The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
On finding a potent compound for the treatment of oral health, researchers examined the effects of WA on periodontitis.
In vitro, Herbal ashwagandha possessed a marked anti-inflammatory effect against the denaturation of proteins associated with the loss of the quaternary structure, tertiary structure, and secondary structure, probably through the herbal alkaloid and withanolide contents.
Furthermore, herbal ashwagandha also induced adaptogenic, immunomodulating, antibacterial, anti-inflammatory against on the onset of periodontitis.
The enzymatic antioxidants such as superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase produced by the host are increased by the administration of WA against bacterial-induced inflammatory periodontitis.
Moreover, Ashwagandha supplementation also showed to process activity to act as an adjunct to scaling and root planing(SRP) in chronic periodontitis(CP) patients by inhibiting oxidative stress (OS) and increased levels of acute-phase proteins associated with gingival inflammation and periodontitis.
Based on the findings, researchers said, "Changes in peripheral blood cellular and molecular components can be seen in patients with periodontitis, as periodontitis includes inflammatory changes of the periodontal tissues".
Taken altogether, Ashwagandha may be considered a functional herb for the prevention and an adjunct therapy combined with the primary medicine for the treatment of periodontitis, pending to the result of larger sample size and multicenter study
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effect of Ashwagandha on Salivary Antioxidant and Serum c Reactive Protein in Chronic Generalized Periodontitis by NIH
(2) Periodontitis by Mayo Clinic
Tuesday, December 31, 2019
Herbal Bilberry Processed Anti Alzheimer's disease Potency in Vitro and Vivo
Alzheimer's disease is a chronic neurodegenerative disease caused by the gradual loss of neuron functioning that usually starts with the early symptom of the difficulty of remembering recent events and worsens over time.
The disease is most prevalent in the elderly and causes over 60% of all cases of dementia.
According to the statistics, approximately 5.7 million Americans of all ages have Alzheimer's. 15.9 million family caregivers provided an estimated 18.2 billion hours and $230 billion to people with dementia worldwide.
Epidemiological studies suggested that Alzheimer's disease is caused by a combination of genetic, lifestyle and environmental factors that affect the neurons of the brain over time.
Although, less than 10% of patients with AD are associated with a genetic preposition. Patients with such a mutated gene are virtually guaranteed to develop the disease.
More precisely, any one of a number of different single-gene mutations on chromosomes 21, 14, and 1 was found to induce the onset of AD.
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
Researchers on finding a natural compound for the treatment of Alzheimer's disease (AD) investigated the effects of anthocyanoside extracts (Vaccinium myrtillus anthocyanoside (VMA)) obtained from bilberry on the in vitro progression of Aβ fibril formation and in vivo effects of this compound on AD pathogenesis.
In Neuro2a cells, injection of VMA inhibited the in vitro formation of Aβ peptide fibrils in the induction of neuron toxicity.
Furthermore, A diet containing 1% VMA prevented the cognitive degeneration was found in the tested AD mice.
Interestingly, this diet in the retention of cognitive ability was not accompanied by a reduction in the aggregate deposition in brains but rather, an increase in insoluble deposits, compared to control mice.
The results suggested that VMA shows a strong effect on Alzheimer's disease by altering the Aβ aggregation to a non-toxic form.
In order to reveal more information about bilberry anti AD activity, researchers elucidated the effects of different polyphenols on neuroprotection and APP processing under different in vitro stress conditions.
Injection of myricetin, quercetin or anthocyanin-rich extracts in a dose-dependent manner significantly inhibited the overexpression of free radicals caused by the application of Menadione.
APdE9 mice fed with anthocyanin-rich bilberry or blackcurrant extracts showed decreased APP C-terminal fragment levels, the amyloid precursor protein in the cerebral cortex, compared to APdE9 mice on the control diet.
Levels of soluble Aβ40 and Aβ42 levels were found to significantly decrease in bilberry-fed mice, compared to blackcurrant-fed mice.
Additionally, the bilberry diet also improved the spatial working memory of aged APdE9 mice, compared to mice on the control diet.
Based on the findings, Dr. Vepsäläinen S, the lead scientist wrote in the final report, "These data suggest that anthocyanin-rich bilberry and blackcurrant diets favorably modulate APP processing and alleviate behavioral abnormalities in a mouse model of AD".
Taken altogether, bilberry rich of anthocyanin may be considered a functional remedy for the prevention and treatment of Alzheimer's disease (AD), pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Anthocyanin suppresses the toxicity of Aβ deposits through diversion of molecular forms in vitro and in vivo models of Alzheimer's disease by Yamakawa MY, Uchino K, Watanabe Y, Adachi T, Nakanishi M, Ichino H, Hongo K, Mizobata T, Kobayashi S, Nakashima K, Kawata Y. (PubMed)
(2) Anthocyanin-enriched bilberry and blackcurrant extracts modulate amyloid precursor protein processing and alleviate behavioral abnormalities in the APP/PS1 mouse model of Alzheimer's disease by Vepsäläinen S1, Koivisto H, Pekkarinen E, Mäkinen P, Dobson G, McDougall GJ, Stewart D, Haapasalo A, Karjalainen RO, Tanila H, Hiltunen M. (PubMed)
The disease is most prevalent in the elderly and causes over 60% of all cases of dementia.
According to the statistics, approximately 5.7 million Americans of all ages have Alzheimer's. 15.9 million family caregivers provided an estimated 18.2 billion hours and $230 billion to people with dementia worldwide.
Epidemiological studies suggested that Alzheimer's disease is caused by a combination of genetic, lifestyle and environmental factors that affect the neurons of the brain over time.
Although, less than 10% of patients with AD are associated with a genetic preposition. Patients with such a mutated gene are virtually guaranteed to develop the disease.
More precisely, any one of a number of different single-gene mutations on chromosomes 21, 14, and 1 was found to induce the onset of AD.
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
Researchers on finding a natural compound for the treatment of Alzheimer's disease (AD) investigated the effects of anthocyanoside extracts (Vaccinium myrtillus anthocyanoside (VMA)) obtained from bilberry on the in vitro progression of Aβ fibril formation and in vivo effects of this compound on AD pathogenesis.
In Neuro2a cells, injection of VMA inhibited the in vitro formation of Aβ peptide fibrils in the induction of neuron toxicity.
Furthermore, A diet containing 1% VMA prevented the cognitive degeneration was found in the tested AD mice.
Interestingly, this diet in the retention of cognitive ability was not accompanied by a reduction in the aggregate deposition in brains but rather, an increase in insoluble deposits, compared to control mice.
The results suggested that VMA shows a strong effect on Alzheimer's disease by altering the Aβ aggregation to a non-toxic form.
In order to reveal more information about bilberry anti AD activity, researchers elucidated the effects of different polyphenols on neuroprotection and APP processing under different in vitro stress conditions.
Injection of myricetin, quercetin or anthocyanin-rich extracts in a dose-dependent manner significantly inhibited the overexpression of free radicals caused by the application of Menadione.
APdE9 mice fed with anthocyanin-rich bilberry or blackcurrant extracts showed decreased APP C-terminal fragment levels, the amyloid precursor protein in the cerebral cortex, compared to APdE9 mice on the control diet.
Levels of soluble Aβ40 and Aβ42 levels were found to significantly decrease in bilberry-fed mice, compared to blackcurrant-fed mice.
Additionally, the bilberry diet also improved the spatial working memory of aged APdE9 mice, compared to mice on the control diet.
Based on the findings, Dr. Vepsäläinen S, the lead scientist wrote in the final report, "These data suggest that anthocyanin-rich bilberry and blackcurrant diets favorably modulate APP processing and alleviate behavioral abnormalities in a mouse model of AD".
Taken altogether, bilberry rich of anthocyanin may be considered a functional remedy for the prevention and treatment of Alzheimer's disease (AD), pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Anthocyanin suppresses the toxicity of Aβ deposits through diversion of molecular forms in vitro and in vivo models of Alzheimer's disease by Yamakawa MY, Uchino K, Watanabe Y, Adachi T, Nakanishi M, Ichino H, Hongo K, Mizobata T, Kobayashi S, Nakashima K, Kawata Y. (PubMed)
(2) Anthocyanin-enriched bilberry and blackcurrant extracts modulate amyloid precursor protein processing and alleviate behavioral abnormalities in the APP/PS1 mouse model of Alzheimer's disease by Vepsäläinen S1, Koivisto H, Pekkarinen E, Mäkinen P, Dobson G, McDougall GJ, Stewart D, Haapasalo A, Karjalainen RO, Tanila H, Hiltunen M. (PubMed)
Andrographis, The Best Anti Platelet Aggregation Herbal Medicine
A recent vitro study suggested that Andrographis paniculata exerted an enormous inhibitory effect on platelet aggregation.
Antiplatelet activity is the effect of decreased platelet aggregation and inhibited thrombus formation.
Andrographis paniculata is also known as Andrographis is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka, used in traditional Siddha and Ayurvedic in treating the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia,.....
According to the Mahidol University, diterpenoids isolated from the plant, including andrographolide (AP(1)) and 14-deoxy-11,12-didehydroandrographolide (AP(3)) in the thrombin-induced platelet aggregation, significantly inhibited blood clot a concentration-(1-100 microM) but not in higher doses, and time-dependent manner.
The study also suggested that the effect of this action was attributed to the inhibition of the regulation of functions in differentiate cells.
Due to inefficacy in applications of higher concentrations, Dr. said, "the extract with high level of AP(3) (Extract B) (IC(50) values=50-75 microg/ml) showed less inhibitory activity against thrombin than the extract with lower level of AP(3) (Extract A) (IC(50) values=25-50 microg/ml). These results indicate that the standardized A. paniculata extract may contain other antiplatelet compounds rather than AP(1) and AP(3), which contribute to high antiplatelet activity".
In comparison to platelet aggregation effects with non-steroidal antiinflammatory drugs (NSAID), treatment of the herbal medicine showed a strong influence on the biosynthesis of eicosanoids in cell signaling and the platelet-activating factor (PAF) with the ability to cause platelet aggregation, inflammation, and allergic response,...
The study also proposed that the mechanism of these actions may be associated with the cardiovascular and antithrombotic activity compared to that of non-steroidal antiinflammatory drugs (NSAID),
Other study insisted that the effects of andrographolide in platelet activation may be a result of reducing the mortality of ADP-induced acute pulmonary thromboembolism and significantly prolonged platelet clumping formation of which decrease the platelet aggregation activity.
Taking together, there is no doubt that herbal Andrographis processes an anti-Platelet Aggregation through exhibiting the functions of various mechanisms. People with bleeding disorders should only take herbal medicine with the permission of related field specialists.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) Inhibitory effect of Andrographis paniculata extract and its active diterpenoids on platelet aggregation by Thisoda P1, Rangkadilok N, Pholphana N, Worasuttayangkurn L, Ruchirawat S, Satayavivad J.(PubMed)
(2) Inhibitory effect of andrographolide from Andrographis paniculata on PAF-induced platelet aggregation by Amroyan E1, Gabrielian E, Panossian A, Wikman G, Wagner H.(PubMed)
(3) A novel role of andrographolide, an NF-kappa B inhibitor, on inhibition of plateletactivation: the pivotal mechanisms of endothelial nitric oxide synthase/cyclic GMP by Lu WJ1, Lee JJ, Chou DS, Jayakumar T, Fong TH, Hsiao G, Sheu JR.(PubMed)
Antiplatelet activity is the effect of decreased platelet aggregation and inhibited thrombus formation.
Andrographis paniculata is also known as Andrographis is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka, used in traditional Siddha and Ayurvedic in treating the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia,.....
According to the Mahidol University, diterpenoids isolated from the plant, including andrographolide (AP(1)) and 14-deoxy-11,12-didehydroandrographolide (AP(3)) in the thrombin-induced platelet aggregation, significantly inhibited blood clot a concentration-(1-100 microM) but not in higher doses, and time-dependent manner.
The study also suggested that the effect of this action was attributed to the inhibition of the regulation of functions in differentiate cells.
Due to inefficacy in applications of higher concentrations, Dr. said, "the extract with high level of AP(3) (Extract B) (IC(50) values=50-75 microg/ml) showed less inhibitory activity against thrombin than the extract with lower level of AP(3) (Extract A) (IC(50) values=25-50 microg/ml). These results indicate that the standardized A. paniculata extract may contain other antiplatelet compounds rather than AP(1) and AP(3), which contribute to high antiplatelet activity".
In comparison to platelet aggregation effects with non-steroidal antiinflammatory drugs (NSAID), treatment of the herbal medicine showed a strong influence on the biosynthesis of eicosanoids in cell signaling and the platelet-activating factor (PAF) with the ability to cause platelet aggregation, inflammation, and allergic response,...
The study also proposed that the mechanism of these actions may be associated with the cardiovascular and antithrombotic activity compared to that of non-steroidal antiinflammatory drugs (NSAID),
Other study insisted that the effects of andrographolide in platelet activation may be a result of reducing the mortality of ADP-induced acute pulmonary thromboembolism and significantly prolonged platelet clumping formation of which decrease the platelet aggregation activity.
Taking together, there is no doubt that herbal Andrographis processes an anti-Platelet Aggregation through exhibiting the functions of various mechanisms. People with bleeding disorders should only take herbal medicine with the permission of related field specialists.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) Inhibitory effect of Andrographis paniculata extract and its active diterpenoids on platelet aggregation by Thisoda P1, Rangkadilok N, Pholphana N, Worasuttayangkurn L, Ruchirawat S, Satayavivad J.(PubMed)
(2) Inhibitory effect of andrographolide from Andrographis paniculata on PAF-induced platelet aggregation by Amroyan E1, Gabrielian E, Panossian A, Wikman G, Wagner H.(PubMed)
(3) A novel role of andrographolide, an NF-kappa B inhibitor, on inhibition of plateletactivation: the pivotal mechanisms of endothelial nitric oxide synthase/cyclic GMP by Lu WJ1, Lee JJ, Chou DS, Jayakumar T, Fong TH, Hsiao G, Sheu JR.(PubMed)
Aloe Vera, the Natural Whole Food in Inhibited HSV-1(Herpes simplex)
Aloe vera may be the next potential topical medicine used for the treatment of oral HSV-1 infections without exerting any toxicity, the study by the renowned institute suggested.
Aloe Vera is species of succulent plant in the genus Aloe, belonging to the Family Xanthorrhoeaceae, native to Sudan. It has become very popular for commercial cultivation due to its health benefits, used in herbal medicine in treating many kinds of diseases, including wound, burn healing, minor skin infections, sebaceous cysts, diabetes, and elevated cholesterol, etc.
Herpes simplex is a contagious disease caused by human herpesvirus 1 and 2, the 2 members of the herpes virus family.
According to the joint study lead by the Shiraz University of Medical Sciences, gel extraction with concentrations of Aloe vera (0.2, 0.5, 1, 2, and 5%) exhibited anti-HSV-1 activity assessed by plaque reduction assay.
Dr. Rezazadeh F, the lead author of the study said, "The inhibitory effect of various concentrations of Aloe vera was observed one hour after the Vero cell was infected with HSV-1. However, there was no significant difference between the two serial concentrations".
Acemannan, an extracted polysaccharide from Aloe vera, has shown to exhibited antiviral activities against herpes simplex virus type 1 (HSV-1), in vivo through activation of immune responses.
A combination with azidothymidine(an antiretroviral medication) and acyclovir(an antiviral medication) administration acted synergistically to inhibit the replication of HIV-1 and herpes simplex virus type 1 (HSV-1), respectively.
In fact, the effects of the combination against U1 cells infected with HIV-1, are also attributed to the function of blocking the potentiate of virus replication without inducing toxicity.
Although Aloe Vera has shown to inhibit the replication of HSV-1 activity through its antiviral property, a more precise understanding of the biological activities is necessary before developing Aloe vera as a pharmaceutical source.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) Assessment of Anti HSV-1 Activity of Aloe Vera Gel Extract: an In Vitro Study by Rezazadeh F1, Moshaverinia M1, Motamedifar M2, Alyaseri M3.(PubMed)
(2) Acemannan, an extracted polysaccharide from Aloe vera: A literature review by Sierra-García GD, Castro-Ríos R, González-Horta A, Lara-Arias J, Chávez-Montes A.(PubMed)
(3) In vitro evaluation of the synergistic antiviral effects of acemannan in combination with azidothymidine and acyclovir by Kahlon JB1, Kemp MC, Yawei N, Carpenter RH, Shannon WM, McAnalley BH.(PubMed)
Aloe Vera is species of succulent plant in the genus Aloe, belonging to the Family Xanthorrhoeaceae, native to Sudan. It has become very popular for commercial cultivation due to its health benefits, used in herbal medicine in treating many kinds of diseases, including wound, burn healing, minor skin infections, sebaceous cysts, diabetes, and elevated cholesterol, etc.
Herpes simplex is a contagious disease caused by human herpesvirus 1 and 2, the 2 members of the herpes virus family.
According to the joint study lead by the Shiraz University of Medical Sciences, gel extraction with concentrations of Aloe vera (0.2, 0.5, 1, 2, and 5%) exhibited anti-HSV-1 activity assessed by plaque reduction assay.
Dr. Rezazadeh F, the lead author of the study said, "The inhibitory effect of various concentrations of Aloe vera was observed one hour after the Vero cell was infected with HSV-1. However, there was no significant difference between the two serial concentrations".
Acemannan, an extracted polysaccharide from Aloe vera, has shown to exhibited antiviral activities against herpes simplex virus type 1 (HSV-1), in vivo through activation of immune responses.
A combination with azidothymidine(an antiretroviral medication) and acyclovir(an antiviral medication) administration acted synergistically to inhibit the replication of HIV-1 and herpes simplex virus type 1 (HSV-1), respectively.
In fact, the effects of the combination against U1 cells infected with HIV-1, are also attributed to the function of blocking the potentiate of virus replication without inducing toxicity.
Although Aloe Vera has shown to inhibit the replication of HSV-1 activity through its antiviral property, a more precise understanding of the biological activities is necessary before developing Aloe vera as a pharmaceutical source.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) Assessment of Anti HSV-1 Activity of Aloe Vera Gel Extract: an In Vitro Study by Rezazadeh F1, Moshaverinia M1, Motamedifar M2, Alyaseri M3.(PubMed)
(2) Acemannan, an extracted polysaccharide from Aloe vera: A literature review by Sierra-García GD, Castro-Ríos R, González-Horta A, Lara-Arias J, Chávez-Montes A.(PubMed)
(3) In vitro evaluation of the synergistic antiviral effects of acemannan in combination with azidothymidine and acyclovir by Kahlon JB1, Kemp MC, Yawei N, Carpenter RH, Shannon WM, McAnalley BH.(PubMed)
Herbal Artichoke Enhanced Nonpathogenic Intestinal Microflora for the Promotion of Digestive Health
Gut microbiota or gastrointestinal microbiota is the complex community of over 10 trillions microorganisms living in our digestive tracts.
Use of antibiotics, diet, drugs, may alter the composition of the microbiota.
Under the normal condition, in healthy individuals, gut microbiota plays a critical role in the modulation of the immune, metabolic and neurobehavioral traits.
In Immunity, gut microbiota stimulates the immune system protective responses to pathogens and the maintenance of tolerance to innocuous antigens.
In metabolism, gut microbiota improve glucose tolerance, mipoprotein profile and atherosclerotic plaque development.
In neurological disease, gut microbiota improved the neuropsychiatric conditions, including depression, autism and Parkinson’s disease.
In other words, the balanced gut microbiota has a strong impact on the protection of our body against abnormal metabolism, infectious diseases, and loss or death of neurons in the initiation of diseases of the central nervous system.
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine as liver protective and detoxified agents, and to treat digestive disorders, abdominal pain gas and bloating, etc.
Researchers on the finding a natural therapeutics for the improvement of nonpathogenic intestinal microflora investigated the dried Jerusalem artichoke(JA) effects on microflora and short-chain fatty acids (SCFA) in the hindgut.in male pigs 1 week fed with JA before slaughter.
The study included 5 experimental groups (n = 11) given different dietary treatments 7 days before slaughter: negative control (basal diet), positive control (basal diet + 9% chicory-inulin), basal diet + 4.1% Jerusalem artichoke, basal diet + 8.1% Jerusalem artichoke and basal diet + 12.2% Jerusalem artichoke.
Increasing levels of Jerusalem artichoke to entire male pigs reduced skatole, a mildly toxic compound in the colon and in feces and level of Clostridium perfringens, type of bad bacterias in the gut in both colon and rectum.
Furthermore, injection of JA also increased the total amount of SCFA (linear, P < 0.05), acetic acid (linear, P < 0.05) and valerianic acid (linear, P < 0.01) produced by the friendly bacteria in your gut in feces.
JA improved intestinal microflora by reducing skatole levels through decreasing in C. perfringens and the increase in SCFA with a subsequent reduction in pH.
Taken altogether, artichoke may be considered a functional formula for the improvement of the intestinal microflora, with no side effects, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Feeding Jerusalem artichoke reduced skatole level and changed intestinalmicrobiota in the gut of entire male pigs by Vhile SG1, Kjos NP, Sørum H, Overland M. (PubMed)
(2) The effects of inulin, dried Jerusalem artichoke tuber and a multispecies probiotic preparation on microbiota ecology and immune status of the large intestine in young pigs by Barszcz M1, Taciak M1, Skomiał J. (PubMed)
Use of antibiotics, diet, drugs, may alter the composition of the microbiota.
Under the normal condition, in healthy individuals, gut microbiota plays a critical role in the modulation of the immune, metabolic and neurobehavioral traits.
In Immunity, gut microbiota stimulates the immune system protective responses to pathogens and the maintenance of tolerance to innocuous antigens.
In metabolism, gut microbiota improve glucose tolerance, mipoprotein profile and atherosclerotic plaque development.
In neurological disease, gut microbiota improved the neuropsychiatric conditions, including depression, autism and Parkinson’s disease.
In other words, the balanced gut microbiota has a strong impact on the protection of our body against abnormal metabolism, infectious diseases, and loss or death of neurons in the initiation of diseases of the central nervous system.
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine as liver protective and detoxified agents, and to treat digestive disorders, abdominal pain gas and bloating, etc.
Researchers on the finding a natural therapeutics for the improvement of nonpathogenic intestinal microflora investigated the dried Jerusalem artichoke(JA) effects on microflora and short-chain fatty acids (SCFA) in the hindgut.in male pigs 1 week fed with JA before slaughter.
The study included 5 experimental groups (n = 11) given different dietary treatments 7 days before slaughter: negative control (basal diet), positive control (basal diet + 9% chicory-inulin), basal diet + 4.1% Jerusalem artichoke, basal diet + 8.1% Jerusalem artichoke and basal diet + 12.2% Jerusalem artichoke.
Increasing levels of Jerusalem artichoke to entire male pigs reduced skatole, a mildly toxic compound in the colon and in feces and level of Clostridium perfringens, type of bad bacterias in the gut in both colon and rectum.
Furthermore, injection of JA also increased the total amount of SCFA (linear, P < 0.05), acetic acid (linear, P < 0.05) and valerianic acid (linear, P < 0.01) produced by the friendly bacteria in your gut in feces.
JA improved intestinal microflora by reducing skatole levels through decreasing in C. perfringens and the increase in SCFA with a subsequent reduction in pH.
Taken altogether, artichoke may be considered a functional formula for the improvement of the intestinal microflora, with no side effects, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Feeding Jerusalem artichoke reduced skatole level and changed intestinalmicrobiota in the gut of entire male pigs by Vhile SG1, Kjos NP, Sørum H, Overland M. (PubMed)
(2) The effects of inulin, dried Jerusalem artichoke tuber and a multispecies probiotic preparation on microbiota ecology and immune status of the large intestine in young pigs by Barszcz M1, Taciak M1, Skomiał J. (PubMed)
Monday, December 30, 2019
Bromelain Promotes and Removes Eschar In Burn Wounds, Human Trials Show
Eschar is a dry, dark scab of dead skin associated with a certain skin condition.
Most cases of eschar are associated with burning or cauterizing that stop bleeding, or prevent the spread of infection.
Most common causes of eschar are burned, a condition that causes severe skin damage. Burn wound can recover without serious health consequences in a few days or weeks depending on the size of the burns.
Burns depending on the severity can be classified into
* First-degree burns affect only the epidermis or outer layer of the skin accompanied by the symptoms of is red, painful, dry, and with no blisters on the affected site.
* Second-degree burns affect the epidermis and part of the dermis layer of the skin accompanied by the symptoms of red, blistered, and swollen and painful on the affected site.
* Third-degree burns not only to destroy the epidermis and dermis but also damage the underlying bones, muscles, and tendons accompanied by no symptoms due to completely damage of the nerves in the area.
Believe it or not, 10 percent burns of a child's body and 15 to 20 percent burns of an adult's body are considered to be major injuries and require medical attention and hospitalization.
The most common types of burns are* Thermal burns caused by external heat sources.
* Radiation burns caused by prolonged exposure to ultraviolet rays of the sun or radiotherapy.
* Chemical burns caused by acids, alkalies, detergents, or solvents.
* Electrical burns caused by electrical current.
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
On finding a potential compound for the treatment of diabetic foot burns, researchers examined the effect of bromelain-based enzymatic debridement with Nexobrid® (Mediwound) on surgical tangential excision of deep dermal and full-thickness burns.
According to the retrospective case series that identified four patients with diabetic foot burns,
Nexobrid® debridement showed significant activity in the development of further eschar and deepening of their wounds a few days after NexoBrid was applied.
In other words, Nexobrid® debridement protects the skin against the formation of dry, dark scab or falling away of dead skin due to surgical tangential excision of deep dermal and full-thickness burns.
Based on the finding, Dr. Berner JE, the lead scientist said, "We would recommend judicious use of this new product in patients with diabetic foot wounds".
Moreover, the joint study led by the University of Heidelberg based on the mutual experience of applying enzymatic debridement in more than 500 adult and pediatric patients by the consensus panelists suggested that the degree of consensus was remarkably high, with a unanimous consensus in 88.2% of statements, and the lowest degree of consensus of 70% in only 3 statements.
More precisely, most patients support the use of Nexobrid® debridement for the treatment of removed eschar in burn wounds and reduced blood loss.
After taking other factors into account, Dr. Hirche C, the lead researcher wrote, "This consensus document may serve as a preliminary guideline for the use of enzymatic debridement with user-oriented recommendations until further evidence and systematic guidelines are available".
Taken altogether, bromelain used alone or combined with conventional medicine may be considered a remedy for the prevention and treatment of eschar in burn wounds, pending to the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Limitations to the use of bromelain-based enzymatic debridement (NexoBrid®) for treating diabetic foot burns: a case series of disappointing results by Berner JE1,2, Keckes D1, Pywell M1, Dheansa B. (PubMed)
(2) Eschar removal by bromelain based enzymatic debridement (Nexobrid®) in burns: An European consensus by Hirche C1, Citterio A2, Hoeksema H3, Koller J4, Lehner M5, Martinez JR6, Monstrey S3, Murray A7, Plock JA8, Sander F9, Schulz A10, Ziegler B11, Kneser U. (PubMed)
(3) Burn Stages and Types of burn by the Stanford Health Care
Most cases of eschar are associated with burning or cauterizing that stop bleeding, or prevent the spread of infection.
Most common causes of eschar are burned, a condition that causes severe skin damage. Burn wound can recover without serious health consequences in a few days or weeks depending on the size of the burns.
Burns depending on the severity can be classified into
* First-degree burns affect only the epidermis or outer layer of the skin accompanied by the symptoms of is red, painful, dry, and with no blisters on the affected site.
* Second-degree burns affect the epidermis and part of the dermis layer of the skin accompanied by the symptoms of red, blistered, and swollen and painful on the affected site.
* Third-degree burns not only to destroy the epidermis and dermis but also damage the underlying bones, muscles, and tendons accompanied by no symptoms due to completely damage of the nerves in the area.
Believe it or not, 10 percent burns of a child's body and 15 to 20 percent burns of an adult's body are considered to be major injuries and require medical attention and hospitalization.
The most common types of burns are* Thermal burns caused by external heat sources.
* Radiation burns caused by prolonged exposure to ultraviolet rays of the sun or radiotherapy.
* Chemical burns caused by acids, alkalies, detergents, or solvents.
* Electrical burns caused by electrical current.
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
On finding a potential compound for the treatment of diabetic foot burns, researchers examined the effect of bromelain-based enzymatic debridement with Nexobrid® (Mediwound) on surgical tangential excision of deep dermal and full-thickness burns.
According to the retrospective case series that identified four patients with diabetic foot burns,
Nexobrid® debridement showed significant activity in the development of further eschar and deepening of their wounds a few days after NexoBrid was applied.
In other words, Nexobrid® debridement protects the skin against the formation of dry, dark scab or falling away of dead skin due to surgical tangential excision of deep dermal and full-thickness burns.
Based on the finding, Dr. Berner JE, the lead scientist said, "We would recommend judicious use of this new product in patients with diabetic foot wounds".
Moreover, the joint study led by the University of Heidelberg based on the mutual experience of applying enzymatic debridement in more than 500 adult and pediatric patients by the consensus panelists suggested that the degree of consensus was remarkably high, with a unanimous consensus in 88.2% of statements, and the lowest degree of consensus of 70% in only 3 statements.
More precisely, most patients support the use of Nexobrid® debridement for the treatment of removed eschar in burn wounds and reduced blood loss.
After taking other factors into account, Dr. Hirche C, the lead researcher wrote, "This consensus document may serve as a preliminary guideline for the use of enzymatic debridement with user-oriented recommendations until further evidence and systematic guidelines are available".
Taken altogether, bromelain used alone or combined with conventional medicine may be considered a remedy for the prevention and treatment of eschar in burn wounds, pending to the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Limitations to the use of bromelain-based enzymatic debridement (NexoBrid®) for treating diabetic foot burns: a case series of disappointing results by Berner JE1,2, Keckes D1, Pywell M1, Dheansa B. (PubMed)
(2) Eschar removal by bromelain based enzymatic debridement (Nexobrid®) in burns: An European consensus by Hirche C1, Citterio A2, Hoeksema H3, Koller J4, Lehner M5, Martinez JR6, Monstrey S3, Murray A7, Plock JA8, Sander F9, Schulz A10, Ziegler B11, Kneser U. (PubMed)
(3) Burn Stages and Types of burn by the Stanford Health Care
Bilberry, Protects the Heart and Blood Vessels Against Cardiovascular Diseases
Scientists may have found a whole fruit for the prevention and treatment of cardiovascular diseases, according to studies.
Cardiovascular diseases (CVD) are a group of conditions associated with blood vessels and the heart.
According to the statistics provided by the World Health Organization, cardiovascular diseases are the number 1 cause of death globally. Approximately, 17.9 million people died from CVDs in 2016, representing 31% of all global deaths.
The most common risk factors associated with CVD are an unhealthy diet, physical inactivity, smoking, and excessive alcohol drinking.
Patients with CVD mostly were found to have some intermediate conditions such as high blood pressure, cholesterol, and glucose and being overweight and obese.
Most common symptoms of CVD include persistent chest pain, chest tightness, chest pressure and chest discomforts, and conditions associated with lower blood circulation due to narrowing blood vessels such as shortness of breath, numbness, weakness or coldness in your legs or arms.
Some people before having a CVD may also experience symptoms of pain in the neck, jaw, throat, upper abdomen or back.
If you experience some of the symptoms aforementioned, please check with your doctor to rule out the possibility.
Some researchers suggested that people inherited the mutated gene from the parent are also at a higher risk of CVD.
Dr. Sunil K. Nadar the lead scientist in the investigation of the genetics of CVD wrote, "The term ‘cardiovascular disease’ (CVD) encompasses a wide spectrum of diseases—including ischaemic heart disease (IHD), congenital structural heart disease and various inherited arrhythmias and cardiomyopathies—each of which has its own etiology and pathogenesis".
And, "Our present understanding seems to suggest that it is not one gene on its own that leads to CVD, but rather an interaction between the effects of various genes".
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
In the differentiation of natural compounds for the treatment of cardiovascular disease (CVD), researchers in a joint study led by the Slovak University of Agriculture in Nitra examined the effects of regular consumption of bilberries on CVD risk reduction.
Women (n=25) and men (n=11) included in the study were asked to consume 150 g of frozen stored bilberries 3 times a week for 6 weeks.
At the end of the study, the consumption of bilberries showed a significant decrease of risk factors associated with the onset of CVD, including total cholesterol (P=.017), LDL-C (P=.0347), TG (P=.001), glucose (P=.005), albumin (P=.001), γ-glutamyltransferase (P=.046), and a positive increase in HDL-C (P=.044).
In men, larger favorable changes were found in total cholesterol, glucose, albumin, aspartate aminotransferase, γ-glutamyltransferase, and HDL-C (P=.009) compared to women.
Interestingly, the injection of bilberry over the period was not induced favorable change but an increase of LDL-C.
Dr, Habanova M, the lead scientist after taking into co and confounders, said, "the regular intake of bilberries can be important to reduce CVD risk, by decreasing LDL-C/TG and increasing HDL-C".
Furthermore, in order to find more information about the bilberry anti CVD effects, researchers investigated the effect of bilberry juice on serum and plasma biomarkers of inflammation and antioxidant status in subjects with elevated levels of at least one risk factor for cardiovascular disease (CVD).
The randomized controlled trial included participants consumed either bilberry juice (n = 31) or water (n = 31) for 4 weeks.
Injection of bilberry juice resulted in a significant decrease in plasma concentrations of C-reactive protein (CRP), interleukin (IL)-6, IL-15, and monokine induced by INF-gamma (MIG).
However, an increase in the plasma concentration of tumor nuclear factor-alpha (TNF-alpha) involved in the acute phase of systematic inflammation was also observed in the bilberry group.
Bilberry juice exerted a significant effect in modulating the protein associated with pro-inflammatory cytokines, through activation of a transcription factor, a crucial protein (nuclear factor- kappa B (NF-kappaB)) associated with chronic inflammatory diseases.
Interestingly, injection of bilberry juice did not induce the change of other clinical parameters, including oxidative stress or antioxidant status.
The findings suggested that bilberry reduced risk CVD by modulating the inflammation processes.
Taken altogether, bilberry may be considered a functional remedy for the prevention and treatment of cardiovascular disease with no side effects, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Intake of bilberries (Vaccinium myrtillus L.) reduced risk factors for cardiovascular disease by inducing favorable changes in lipoprotein profiles by Habanova M1, Saraiva JA2, Haban M3, Schwarzova M4, Chlebo P5, Predna L6, Gažo J7, Wyka J. (PubMed)
(2) Bilberry juice modulates plasma concentration of NF-kappaB related inflammatory markers in subjects at increased risk of CVD by Karlsen A1, Paur I, Bøhn SK, Sakhi AK, Borge GI, Serafini M, Erlund I, Laake P, Tonstad S, Blomhoff R. (PubMed)
(3) Genes and Cardiovascular Disease. Where do we go from here? by Sunil K. Nadar1,* and Kully Sandhu. (PMC)
Cardiovascular diseases (CVD) are a group of conditions associated with blood vessels and the heart.
According to the statistics provided by the World Health Organization, cardiovascular diseases are the number 1 cause of death globally. Approximately, 17.9 million people died from CVDs in 2016, representing 31% of all global deaths.
The most common risk factors associated with CVD are an unhealthy diet, physical inactivity, smoking, and excessive alcohol drinking.
Patients with CVD mostly were found to have some intermediate conditions such as high blood pressure, cholesterol, and glucose and being overweight and obese.
Most common symptoms of CVD include persistent chest pain, chest tightness, chest pressure and chest discomforts, and conditions associated with lower blood circulation due to narrowing blood vessels such as shortness of breath, numbness, weakness or coldness in your legs or arms.
Some people before having a CVD may also experience symptoms of pain in the neck, jaw, throat, upper abdomen or back.
If you experience some of the symptoms aforementioned, please check with your doctor to rule out the possibility.
Some researchers suggested that people inherited the mutated gene from the parent are also at a higher risk of CVD.
Dr. Sunil K. Nadar the lead scientist in the investigation of the genetics of CVD wrote, "The term ‘cardiovascular disease’ (CVD) encompasses a wide spectrum of diseases—including ischaemic heart disease (IHD), congenital structural heart disease and various inherited arrhythmias and cardiomyopathies—each of which has its own etiology and pathogenesis".
And, "Our present understanding seems to suggest that it is not one gene on its own that leads to CVD, but rather an interaction between the effects of various genes".
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
In the differentiation of natural compounds for the treatment of cardiovascular disease (CVD), researchers in a joint study led by the Slovak University of Agriculture in Nitra examined the effects of regular consumption of bilberries on CVD risk reduction.
Women (n=25) and men (n=11) included in the study were asked to consume 150 g of frozen stored bilberries 3 times a week for 6 weeks.
At the end of the study, the consumption of bilberries showed a significant decrease of risk factors associated with the onset of CVD, including total cholesterol (P=.017), LDL-C (P=.0347), TG (P=.001), glucose (P=.005), albumin (P=.001), γ-glutamyltransferase (P=.046), and a positive increase in HDL-C (P=.044).
In men, larger favorable changes were found in total cholesterol, glucose, albumin, aspartate aminotransferase, γ-glutamyltransferase, and HDL-C (P=.009) compared to women.
Interestingly, the injection of bilberry over the period was not induced favorable change but an increase of LDL-C.
Dr, Habanova M, the lead scientist after taking into co and confounders, said, "the regular intake of bilberries can be important to reduce CVD risk, by decreasing LDL-C/TG and increasing HDL-C".
Furthermore, in order to find more information about the bilberry anti CVD effects, researchers investigated the effect of bilberry juice on serum and plasma biomarkers of inflammation and antioxidant status in subjects with elevated levels of at least one risk factor for cardiovascular disease (CVD).
The randomized controlled trial included participants consumed either bilberry juice (n = 31) or water (n = 31) for 4 weeks.
Injection of bilberry juice resulted in a significant decrease in plasma concentrations of C-reactive protein (CRP), interleukin (IL)-6, IL-15, and monokine induced by INF-gamma (MIG).
However, an increase in the plasma concentration of tumor nuclear factor-alpha (TNF-alpha) involved in the acute phase of systematic inflammation was also observed in the bilberry group.
Bilberry juice exerted a significant effect in modulating the protein associated with pro-inflammatory cytokines, through activation of a transcription factor, a crucial protein (nuclear factor- kappa B (NF-kappaB)) associated with chronic inflammatory diseases.
Interestingly, injection of bilberry juice did not induce the change of other clinical parameters, including oxidative stress or antioxidant status.
The findings suggested that bilberry reduced risk CVD by modulating the inflammation processes.
Taken altogether, bilberry may be considered a functional remedy for the prevention and treatment of cardiovascular disease with no side effects, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Intake of bilberries (Vaccinium myrtillus L.) reduced risk factors for cardiovascular disease by inducing favorable changes in lipoprotein profiles by Habanova M1, Saraiva JA2, Haban M3, Schwarzova M4, Chlebo P5, Predna L6, Gažo J7, Wyka J. (PubMed)
(2) Bilberry juice modulates plasma concentration of NF-kappaB related inflammatory markers in subjects at increased risk of CVD by Karlsen A1, Paur I, Bøhn SK, Sakhi AK, Borge GI, Serafini M, Erlund I, Laake P, Tonstad S, Blomhoff R. (PubMed)
(3) Genes and Cardiovascular Disease. Where do we go from here? by Sunil K. Nadar1,* and Kully Sandhu. (PMC)
Herbal Ashwagandha inhibits the Risk of Pancreatic Cancer
Cancer is a class of diseases in which a group of cells growing and multiplying disordered and uncontrollable ways in our body, due to the change of cellular DNA. Most cases of cancer start in the cells on the surface of the inner lining of the tissue of the organ.
However, at the later stage of the tumor progression, if undetected, the large size of the tumor can suppress and break the nearby small blood vessel, leading to internal bleeding and severe if the tumor also suppresses the nearby nerve cells.
Primary cancer cells at this advanced stage can also travel a distance away from the original site to affect other healthy tissue and organs, leading to secondary metastasis.
Pancreatic cancer is a medical and chronic condition characterized by irregular cell growth in the tissue of the pancreas.
In the early stage, pancreatic cancer starts in the cells of the surface of the inner lining of pancreatic tissue. At the advanced stage, cancerous cells of the pancreas can travel a distance away to invade other healthy tissue and organs.
The exact causes of the alternation of DNA of pancreatic cells are unknown. However, epidemiological studies suggested that genetic preposition and acquired gene mutations are associated with the increased incidence of cancer.
Some researchers suggested long-term use of tobacco, being overweight and obesity, exposure to workplace chemicals, age, gender and family history are some prevalent risk factors of pancreatic cancer.
According to the statistics, pancreatic cancer is the eighth most common cancer in women and the fourth leading cause of cancer death in men. Pancreatic cancer accounts for 7% of all cancer deaths.
The 5 years survival rate at stage 1 and 2 is 61% and 52% respectively.
Cascara sagrada is a species of buckthorn, genus Rhamnus, belonging to the family Rhamnaceae, native to western North America.
Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean. The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
On finding a potent compound for the treatment of cancer, researchers examined the withaferin-A (WA), the biologically active withanolide extracted from Withania somnifera in human pancreatic cancer cells.
According to the tested analysis, the extract significantly increased the cells spherical structure with double-layer membranes degraded by autophagy through cleaning out damaged cells in normal cells.
However, in human pancreatic cancer (PC) cells, withanolide extract also blocked the degradation of autophagy by inhibiting SNARE protein in the the-mediated fusion of autophagosomes and lysosomes which contains degradative enzymes enclosed in a membrane.
In other words, in human pancreatic cancer (PC) cells, the extract promotes the cancer cell degradation by autophagy to induce apoptosis.
More precisely, WA induced ER stress-mediated apoptosis. by promoting the accumulation of ubiquitinated proteins, associated with degradation via the proteasome, a protein involved in degrading unneeded or damaged proteins.
In vivo, combining WA with a series of ER stress aggravators enhanced apoptosis synergistically in tumor growth in PC xenografts.
Based on the findings, researchers said, "simultaneous suppression of 2 key intracellular protein degradation systems rendered PC cells vulnerable to ER stress, which may represent an avenue for new therapeutic combinations for this disease".
Taken altogether, Ashwagandha may be considered a functional herb for the prevention and an adjunct therapy combined with the primary medicine for the treatment of pancreatic cancer, pending to the result of larger sample size and multicenter study
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Simultaneous inhibition of the ubiquitin-proteasome system and autophagy enhances apoptosis induced by ER stress aggravators in human pancreatic cancer cells by Li X1, Zhu F1, Jiang J2, Sun C3, Zhong Q4, Shen M1, Wang X1, Tian R1, Shi C1, Xu M1, Peng F1, Guo X1, Hu J5, Ye D6, Wang M1, Qin R. (PubMed)
However, at the later stage of the tumor progression, if undetected, the large size of the tumor can suppress and break the nearby small blood vessel, leading to internal bleeding and severe if the tumor also suppresses the nearby nerve cells.
Primary cancer cells at this advanced stage can also travel a distance away from the original site to affect other healthy tissue and organs, leading to secondary metastasis.
Pancreatic cancer is a medical and chronic condition characterized by irregular cell growth in the tissue of the pancreas.
In the early stage, pancreatic cancer starts in the cells of the surface of the inner lining of pancreatic tissue. At the advanced stage, cancerous cells of the pancreas can travel a distance away to invade other healthy tissue and organs.
The exact causes of the alternation of DNA of pancreatic cells are unknown. However, epidemiological studies suggested that genetic preposition and acquired gene mutations are associated with the increased incidence of cancer.
Some researchers suggested long-term use of tobacco, being overweight and obesity, exposure to workplace chemicals, age, gender and family history are some prevalent risk factors of pancreatic cancer.
According to the statistics, pancreatic cancer is the eighth most common cancer in women and the fourth leading cause of cancer death in men. Pancreatic cancer accounts for 7% of all cancer deaths.
The 5 years survival rate at stage 1 and 2 is 61% and 52% respectively.
Cascara sagrada is a species of buckthorn, genus Rhamnus, belonging to the family Rhamnaceae, native to western North America.
Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean. The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
On finding a potent compound for the treatment of cancer, researchers examined the withaferin-A (WA), the biologically active withanolide extracted from Withania somnifera in human pancreatic cancer cells.
According to the tested analysis, the extract significantly increased the cells spherical structure with double-layer membranes degraded by autophagy through cleaning out damaged cells in normal cells.
However, in human pancreatic cancer (PC) cells, withanolide extract also blocked the degradation of autophagy by inhibiting SNARE protein in the the-mediated fusion of autophagosomes and lysosomes which contains degradative enzymes enclosed in a membrane.
In other words, in human pancreatic cancer (PC) cells, the extract promotes the cancer cell degradation by autophagy to induce apoptosis.
More precisely, WA induced ER stress-mediated apoptosis. by promoting the accumulation of ubiquitinated proteins, associated with degradation via the proteasome, a protein involved in degrading unneeded or damaged proteins.
In vivo, combining WA with a series of ER stress aggravators enhanced apoptosis synergistically in tumor growth in PC xenografts.
Based on the findings, researchers said, "simultaneous suppression of 2 key intracellular protein degradation systems rendered PC cells vulnerable to ER stress, which may represent an avenue for new therapeutic combinations for this disease".
Taken altogether, Ashwagandha may be considered a functional herb for the prevention and an adjunct therapy combined with the primary medicine for the treatment of pancreatic cancer, pending to the result of larger sample size and multicenter study
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Simultaneous inhibition of the ubiquitin-proteasome system and autophagy enhances apoptosis induced by ER stress aggravators in human pancreatic cancer cells by Li X1, Zhu F1, Jiang J2, Sun C3, Zhong Q4, Shen M1, Wang X1, Tian R1, Shi C1, Xu M1, Peng F1, Guo X1, Hu J5, Ye D6, Wang M1, Qin R. (PubMed)
Herbal Artichoke Inhibits the Parameters Associated with the Onset of Non-Alcoholic Fatty Liver Disease (NAFLD) in Vivo and Human Study
Non-alcoholic liver disease is a medical condition caused by excessive fat accumulated in the liver of people who drink little or no alcohol.
Believe it or not, non-alcoholic fatty liver disease (NAFLD) now becomes a universal disorder and the most common liver disease in the Western world.
According to the statistics in 2015, approximately, 20 to 30% of the general population in the Western world suffer from NAFLD. The prevalent rate is substantially higher in the population with type 2 diabetes mellitus (70%) and morbid obesity (90%).
Some researchers in the assessment of the relationship of widespread obesity in the risk of NAFLD suggested that non-alcoholic fatty liver disease may be caused by the promotion of the Western diet over the past few decades.
Dr. Kristen Stephenson, in the assessment of the impact of dietary fat on the development of non-alcoholic fatty liver disease in animal model, wrote, "WD mouse models consisting of high fat, cholesterol, and a combination of high-fructose corn syrup, sucrose, fructose, or glucose not only lead to metabolic syndrome but also induce NAFLD with fibrosis".
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine as liver protective and detoxified agents, and to treat digestive disorders, abdominal pain gas and bloating, etc.
Researchers on finding a natural therapeutic for the treatment of Non-alcoholic fatty liver disease (NAFLD), the most common cause of chronic liver disease worldwide investigated the artichoke leaf extract (ALE) therapeutic utility in patients with established NAFLD.
The randomized double-blind placebo-controlled parallel-group trial included 100 subjects with ultrasound-diagnosed NAFLD randomized to either ALE 600 mg daily or placebo for a 2-month period.
Compared to the control, the ALE treatment group showed increased hepatic vein flow, reduced portal vein diameter and liver size, according to the Doppler sonography. In other words, ALE treatment improved liver function.
Inflammatory and oxidative stress such as serum ALT, AST levels and total bilirubin were also decreased upon the injection of ALE observed by the improved AST/ALT ratio.
Furthermore, ALE supplementation also reduced total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, non-high-density lipoprotein cholesterol, and triglyceride concentrations. All these parameters were elevated in patients with NAFLD.
Dr. Panahi Y, the lead scientist, after taking into account other factors, wrote, " This study has shown beneficial effects of ALE supplementation on both ultrasound liver parameters and liver serum parameters (ALT, AST, APRI ratio, and total bilirubin) in patients with NAFLD".
In order to reveal more information about artichoke anti NAFLD activity, researchers elucidated the physiological responses and mechanisms of JA intervention with comprehensive transcriptome analysis.
The study included Wistar rats fed a control diet, a 60 % fructose-enriched diet (FRU), or an FRU with 10 % JA (n 6-7) for 4 weeks with an oral glucose tolerance test was carried out on day 21.
According to the assays, dietary JA supplementation improved the IR and hepatic TAG accumulation induced by the Fructose feeding.
JA also inhibited the gene expression of malic enzyme 1 (Me1), associated with fatty acid synthesis; decorin (Dcn), related to fibrosis; and cytochrome P450, family 1, subfamily a, polypeptide 2 (Cyp1a2) and nicotinamide phosphoribosyltransferase (Nampt), associated with inflammation.
Based on these results, researchers proposed that 10 % of JA supplementation may be beneficial for the prevention of the onset of NAFLD.
Taken altogether, artichoke may be considered a functional remedy for the treatment of NAFLD with no side effects, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Efficacy of artichoke leaf extract in non-alcoholic fatty liver disease: A pilot double-blind randomized controlled trial by Panahi Y1, Kianpour P2, Mohtashami R3, Atkin SL4, Butler AE5, Jafari R6, Badeli R7, Sahebkar A. (PubMed)
(2) Beneficial effects of soluble dietary Jerusalem artichoke (Helianthus tuberosus) in the prevention of the onset of type 2 diabetes and non-alcoholic fatty liver disease in high-fructose diet-fed rats by Chang WC1, Jia H2, Aw W2, Saito K2, Hasegawa S3, Kato H. (PubMed)
(3) Updates on Dietary Models of Nonalcoholic Fatty Liver Disease: Current Studies and Insights by Kristen Stephenson,* 1 Lindsey Kennedy,†‡ 1 Laura Hargrove,‡ Jennifer Demieville,†Joanne Thomson,† Gianfranco Alpini,*†‡ and Heather Francis. (PMC)
Believe it or not, non-alcoholic fatty liver disease (NAFLD) now becomes a universal disorder and the most common liver disease in the Western world.
According to the statistics in 2015, approximately, 20 to 30% of the general population in the Western world suffer from NAFLD. The prevalent rate is substantially higher in the population with type 2 diabetes mellitus (70%) and morbid obesity (90%).
Some researchers in the assessment of the relationship of widespread obesity in the risk of NAFLD suggested that non-alcoholic fatty liver disease may be caused by the promotion of the Western diet over the past few decades.
Dr. Kristen Stephenson, in the assessment of the impact of dietary fat on the development of non-alcoholic fatty liver disease in animal model, wrote, "WD mouse models consisting of high fat, cholesterol, and a combination of high-fructose corn syrup, sucrose, fructose, or glucose not only lead to metabolic syndrome but also induce NAFLD with fibrosis".
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine as liver protective and detoxified agents, and to treat digestive disorders, abdominal pain gas and bloating, etc.
Researchers on finding a natural therapeutic for the treatment of Non-alcoholic fatty liver disease (NAFLD), the most common cause of chronic liver disease worldwide investigated the artichoke leaf extract (ALE) therapeutic utility in patients with established NAFLD.
The randomized double-blind placebo-controlled parallel-group trial included 100 subjects with ultrasound-diagnosed NAFLD randomized to either ALE 600 mg daily or placebo for a 2-month period.
Compared to the control, the ALE treatment group showed increased hepatic vein flow, reduced portal vein diameter and liver size, according to the Doppler sonography. In other words, ALE treatment improved liver function.
Inflammatory and oxidative stress such as serum ALT, AST levels and total bilirubin were also decreased upon the injection of ALE observed by the improved AST/ALT ratio.
Furthermore, ALE supplementation also reduced total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, non-high-density lipoprotein cholesterol, and triglyceride concentrations. All these parameters were elevated in patients with NAFLD.
Dr. Panahi Y, the lead scientist, after taking into account other factors, wrote, " This study has shown beneficial effects of ALE supplementation on both ultrasound liver parameters and liver serum parameters (ALT, AST, APRI ratio, and total bilirubin) in patients with NAFLD".
In order to reveal more information about artichoke anti NAFLD activity, researchers elucidated the physiological responses and mechanisms of JA intervention with comprehensive transcriptome analysis.
The study included Wistar rats fed a control diet, a 60 % fructose-enriched diet (FRU), or an FRU with 10 % JA (n 6-7) for 4 weeks with an oral glucose tolerance test was carried out on day 21.
According to the assays, dietary JA supplementation improved the IR and hepatic TAG accumulation induced by the Fructose feeding.
JA also inhibited the gene expression of malic enzyme 1 (Me1), associated with fatty acid synthesis; decorin (Dcn), related to fibrosis; and cytochrome P450, family 1, subfamily a, polypeptide 2 (Cyp1a2) and nicotinamide phosphoribosyltransferase (Nampt), associated with inflammation.
Based on these results, researchers proposed that 10 % of JA supplementation may be beneficial for the prevention of the onset of NAFLD.
Taken altogether, artichoke may be considered a functional remedy for the treatment of NAFLD with no side effects, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Efficacy of artichoke leaf extract in non-alcoholic fatty liver disease: A pilot double-blind randomized controlled trial by Panahi Y1, Kianpour P2, Mohtashami R3, Atkin SL4, Butler AE5, Jafari R6, Badeli R7, Sahebkar A. (PubMed)
(2) Beneficial effects of soluble dietary Jerusalem artichoke (Helianthus tuberosus) in the prevention of the onset of type 2 diabetes and non-alcoholic fatty liver disease in high-fructose diet-fed rats by Chang WC1, Jia H2, Aw W2, Saito K2, Hasegawa S3, Kato H. (PubMed)
(3) Updates on Dietary Models of Nonalcoholic Fatty Liver Disease: Current Studies and Insights by Kristen Stephenson,* 1 Lindsey Kennedy,†‡ 1 Laura Hargrove,‡ Jennifer Demieville,†Joanne Thomson,† Gianfranco Alpini,*†‡ and Heather Francis. (PMC)
Andrographis, The Best Whole Herb Medicine for Treatment of Ulcerative Colitis
Ulcerative colitis is a condition of inflammatory bowel disease (IBD) inducing long-lasting inflammation and ulcers in the digestive tract.
Andrographis paniculata is also known as Andrographis is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka, used in traditional Siddha and Ayurvedic in treating the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia,...
In a randomized, double-blind, placebo-controlled trial in evaluating the efficacy of A. paniculata extract (HMPL-004) in 224 adults with mild-to-moderate ulcerative colitis. with patients randomized to A. paniculata extract (HMPL-004) 1,200 mg or 1,800 mg daily or placebo for 8 weeks, patients treated with A. paniculata extract (HMPL-004) at a dose of 1,800 mg daily achieve clinical response than those receiving placebo.
The study also discovered that 60 and 53% of patients treated with A. paniculata groups experienced adverse effects at doses of 1,200 mg and 1,800 mg daily respectively in comparison to 60% in the placebo group.
Dr. Sandborn WJ, the lead author in the study said, "Andrographis paniculata has in vitro inhibitory activity against TNF-α, IL-1β, and NF-κB. A pilot study of A. paniculata extract (HMPL-004) suggested similar efficacy to mesalamine for ulcerative colitis."
Other study involved herbal extract HMPL-004 also support the use of herbal extract for treatment in patients with mild-to-moderate ulcerative colitis, according to the randomized, double-blind, multicentre, 8-week parallel-group study conducted using HMPL-004 with 1200 mg/day in compared with 4500 mg/day of slow-release mesalazine (mesalamine) granules in the same group.
In fact, in comparison to mesalazine, HMPL-004 exhibited a 21% and 76% of more efficacy in treated patients, compared to 16% and 82% of mesalazine-treated patients through the colonoscopy, remission, and response.
Although HMPL-004 may be an efficacious alternative to mesalazine in treating ulcerative colitis, the herbal medicine can only be prescribed by herbalists to prevent overdose toxicity.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) Andrographis paniculata extract (HMPL-004) for active ulcerative colitis by Sandborn WJ1, Targan SR, Byers VS, Rutty DA, Mu H, Zhang X, Tang T.(PubMed)
(2) Randomised clinical trial: herbal extract HMPL-004 in active ulcerative colitis - a double-blind comparison with sustained release mesalazine by Tang T1, Targan SR, Li ZS, Xu C, Byers VS, Sandborn WJ.(PubMed)
Andrographis paniculata is also known as Andrographis is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka, used in traditional Siddha and Ayurvedic in treating the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia,...
In a randomized, double-blind, placebo-controlled trial in evaluating the efficacy of A. paniculata extract (HMPL-004) in 224 adults with mild-to-moderate ulcerative colitis. with patients randomized to A. paniculata extract (HMPL-004) 1,200 mg or 1,800 mg daily or placebo for 8 weeks, patients treated with A. paniculata extract (HMPL-004) at a dose of 1,800 mg daily achieve clinical response than those receiving placebo.
The study also discovered that 60 and 53% of patients treated with A. paniculata groups experienced adverse effects at doses of 1,200 mg and 1,800 mg daily respectively in comparison to 60% in the placebo group.
Dr. Sandborn WJ, the lead author in the study said, "Andrographis paniculata has in vitro inhibitory activity against TNF-α, IL-1β, and NF-κB. A pilot study of A. paniculata extract (HMPL-004) suggested similar efficacy to mesalamine for ulcerative colitis."
Other study involved herbal extract HMPL-004 also support the use of herbal extract for treatment in patients with mild-to-moderate ulcerative colitis, according to the randomized, double-blind, multicentre, 8-week parallel-group study conducted using HMPL-004 with 1200 mg/day in compared with 4500 mg/day of slow-release mesalazine (mesalamine) granules in the same group.
In fact, in comparison to mesalazine, HMPL-004 exhibited a 21% and 76% of more efficacy in treated patients, compared to 16% and 82% of mesalazine-treated patients through the colonoscopy, remission, and response.
Although HMPL-004 may be an efficacious alternative to mesalazine in treating ulcerative colitis, the herbal medicine can only be prescribed by herbalists to prevent overdose toxicity.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) Andrographis paniculata extract (HMPL-004) for active ulcerative colitis by Sandborn WJ1, Targan SR, Byers VS, Rutty DA, Mu H, Zhang X, Tang T.(PubMed)
(2) Randomised clinical trial: herbal extract HMPL-004 in active ulcerative colitis - a double-blind comparison with sustained release mesalazine by Tang T1, Targan SR, Li ZS, Xu C, Byers VS, Sandborn WJ.(PubMed)
Sunday, December 29, 2019
Bilberry Inhibits the Risk and Progression of Colon Cancer, According to Researchers
Colon cancer is a medical and chronic condition characterized by the growth of the cells disorderly and uncontrollably in the colon tissue.
Most cases of colon cancers begin in the cells on the surface of the inner lining due to the alternation of DNA.
Colon cancer is one most slow-growing cancer. It may take years before patients experiencing the symptoms.
At the later stage, the larger size of the tumor may suppress the nearby blood vessels and nerve cells, leading to localized severe pain and bleeding.
The most common symptoms of colon cancer in the advanced stage, besides the general symptom of cancer such as reduced appetite, unintended weight loss include a change of bowel movement, rectal bleeding, and persistent abdominal pain and cramp.
If you experience some of the above symptoms, please check with your doctor to rule out the possibility of colon cancer.
According to the statistics, in 2017, approximately 26,800 Canadians were diagnosed with colorectal cancer, representing 13% of all new cancer cases.
Depending on the stage, early diagnosis of localized colon cancer has a 5-year relative survival rate of over 90%.
Out of a number of the risk factors, obesity may be one that causes the majority of colon cancer in the Western world, particularly in North American.
Dr. E E Frezza, the lead scientist in the assessment of obesity on the risk of developing colon cancer, said, "Visceral abdominal fat has been identified as the essential fat depot for pathogenetic theories that relate obesity and colon cancer".
And, "Obesity imposes a greater risk of colon cancer for men of all ages and for premenopausal women than it does for postmenopausal women. Regular exercise reduces the risk of developing colon cancer and the risk of death from colon cancer should it develop. We believe that a combination of waist circumference (WC) and body mass index (BMI) measurements are recommended to assess the obesity-related risk of developing colon cancer".
The results suggested that if you are obese, your risk of colon cancer is increased much fold compared to healthy weight individuals.
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The herbal plant has been used as foods and herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
Researchers on finding a natural compound for the treatment of colon cancer examined the bilberry derived anthocyanins chemopreventive properties.
The study included 50 female Balb/c mice induced colonic carcinogenesis by AOM and DSS 3 or 5%, respectively, Mice then are given either normal food (controls) or a diet containing either 10 or 1% anthocyanin-rich bilberry extract.
According to the colonoscopy taken place at weeks 4 and 9 after initiation of carcinogenesis, mice receiving 10% anthocyanins showed significantly (p < 0.004) less reduced colon length (12.1 cm [8.5-14.4 cm]) as compared to controls (11.2 cm [9.8-12.3]) indicating less inflammation.
Furthermore, mice fed with 10% anthocyanin-rich extract revealed significantly less mean tumor numbers, compared to control (n = 14) and anthocyanin 1% treated mice.
The results suggested that anthocyanins inhibited the formation and growth of colorectal cancer in an animal model.
In order to reveal more information about anthocyanins anti-colon cancer activity, researchers examined the compound on human colon and colorectal cancer cells (DLD-1 and COLO205).
Using the optimum process of A(V.uli) extraction involved conditions of temperature 20°C, pH 2.0, and diatomaceous earth 1.0 g/50 g of fruit weight. A(V.uli), 5 main components: delphinidin (40.70 ± 1.72)%, cyanidin (3.40 ± 0.68)%, petunidin (17.70 ± 0.54)%, peonidin (2.90 ± 0.63)% and malvidin (35.50 ± 1.11)% were found in the anthocyanins extract.
Malvidin, the derivatives found in the extracts exerted the strongest anti-colon cancer cell properties with dose-dependent repression of cancer cell proliferation with an IC(50) (50% inhibitory concentration) value of 50 µg/ml, compared to other derivatives.
Dr. Zu XY and colleagues wrote in the final report, "The extraction protocol and conditions we used were effective for anthocyanin extraction. A(V.uli) could be a feasible practical research tool and a promising therapeutic source to suppress human colon or colorectal cancers".
Taken altogether, bilberry processed abundantly bioactive compounds anthocyanin and malvidin may be considered a functional remedy for the prevention and treatment of colon cancer, pending to the confirmation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Anthocyanins Prevent Colorectal Cancer Development in a Mouse Model by Lippert E1, Ruemmele P, Obermeier F, Goelder S, Kunst C, Rogler G, Dunger N, Messmann H, Hartmann A, Endlicher E. (PubMed)
(2) Anthocyanins extracted from Chinese blueberry (Vaccinium uliginosum L.) and its anticancer effects on DLD-1 and COLO205 cells by Zu XY1, Zhang ZY, Zhang XW, Yoshioka M, Yang YN, Li J. (PubMed)
(3) Influence of obesity on the risk of developing colon cancer by E E Frezza, M S Wachtel, and M Chiriva‐Internati. (PMC)
Most cases of colon cancers begin in the cells on the surface of the inner lining due to the alternation of DNA.
Colon cancer is one most slow-growing cancer. It may take years before patients experiencing the symptoms.
At the later stage, the larger size of the tumor may suppress the nearby blood vessels and nerve cells, leading to localized severe pain and bleeding.
The most common symptoms of colon cancer in the advanced stage, besides the general symptom of cancer such as reduced appetite, unintended weight loss include a change of bowel movement, rectal bleeding, and persistent abdominal pain and cramp.
If you experience some of the above symptoms, please check with your doctor to rule out the possibility of colon cancer.
According to the statistics, in 2017, approximately 26,800 Canadians were diagnosed with colorectal cancer, representing 13% of all new cancer cases.
Depending on the stage, early diagnosis of localized colon cancer has a 5-year relative survival rate of over 90%.
Out of a number of the risk factors, obesity may be one that causes the majority of colon cancer in the Western world, particularly in North American.
Dr. E E Frezza, the lead scientist in the assessment of obesity on the risk of developing colon cancer, said, "Visceral abdominal fat has been identified as the essential fat depot for pathogenetic theories that relate obesity and colon cancer".
And, "Obesity imposes a greater risk of colon cancer for men of all ages and for premenopausal women than it does for postmenopausal women. Regular exercise reduces the risk of developing colon cancer and the risk of death from colon cancer should it develop. We believe that a combination of waist circumference (WC) and body mass index (BMI) measurements are recommended to assess the obesity-related risk of developing colon cancer".
The results suggested that if you are obese, your risk of colon cancer is increased much fold compared to healthy weight individuals.
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The herbal plant has been used as foods and herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
Researchers on finding a natural compound for the treatment of colon cancer examined the bilberry derived anthocyanins chemopreventive properties.
The study included 50 female Balb/c mice induced colonic carcinogenesis by AOM and DSS 3 or 5%, respectively, Mice then are given either normal food (controls) or a diet containing either 10 or 1% anthocyanin-rich bilberry extract.
According to the colonoscopy taken place at weeks 4 and 9 after initiation of carcinogenesis, mice receiving 10% anthocyanins showed significantly (p < 0.004) less reduced colon length (12.1 cm [8.5-14.4 cm]) as compared to controls (11.2 cm [9.8-12.3]) indicating less inflammation.
Furthermore, mice fed with 10% anthocyanin-rich extract revealed significantly less mean tumor numbers, compared to control (n = 14) and anthocyanin 1% treated mice.
The results suggested that anthocyanins inhibited the formation and growth of colorectal cancer in an animal model.
In order to reveal more information about anthocyanins anti-colon cancer activity, researchers examined the compound on human colon and colorectal cancer cells (DLD-1 and COLO205).
Using the optimum process of A(V.uli) extraction involved conditions of temperature 20°C, pH 2.0, and diatomaceous earth 1.0 g/50 g of fruit weight. A(V.uli), 5 main components: delphinidin (40.70 ± 1.72)%, cyanidin (3.40 ± 0.68)%, petunidin (17.70 ± 0.54)%, peonidin (2.90 ± 0.63)% and malvidin (35.50 ± 1.11)% were found in the anthocyanins extract.
Malvidin, the derivatives found in the extracts exerted the strongest anti-colon cancer cell properties with dose-dependent repression of cancer cell proliferation with an IC(50) (50% inhibitory concentration) value of 50 µg/ml, compared to other derivatives.
Dr. Zu XY and colleagues wrote in the final report, "The extraction protocol and conditions we used were effective for anthocyanin extraction. A(V.uli) could be a feasible practical research tool and a promising therapeutic source to suppress human colon or colorectal cancers".
Taken altogether, bilberry processed abundantly bioactive compounds anthocyanin and malvidin may be considered a functional remedy for the prevention and treatment of colon cancer, pending to the confirmation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Anthocyanins Prevent Colorectal Cancer Development in a Mouse Model by Lippert E1, Ruemmele P, Obermeier F, Goelder S, Kunst C, Rogler G, Dunger N, Messmann H, Hartmann A, Endlicher E. (PubMed)
(2) Anthocyanins extracted from Chinese blueberry (Vaccinium uliginosum L.) and its anticancer effects on DLD-1 and COLO205 cells by Zu XY1, Zhang ZY, Zhang XW, Yoshioka M, Yang YN, Li J. (PubMed)
(3) Influence of obesity on the risk of developing colon cancer by E E Frezza, M S Wachtel, and M Chiriva‐Internati. (PMC)
Bromelain Inhibits Cancer Initiation and Progression in Vitro and Vivo
Cancer is a class of chronic and medical conditions caused by the alternation of cell DNA.
Most cases of cancer start in the cells on the surface of the inner lining of specific tissues and organs.
At the early stage due to the very small size of the tumor, most cancers are asymptomatic. However, at the advanced stage, cancer only can induce general symptoms such as gastrointestinal discomfort, unintended weight loss, fatigue, and loss but also lead to specific symptoms, such as localized bleeding and pain, depending on the location of cancer.
Also, at this stage, primary cancer cells can travel a distance away from the original site to infect other healthy tissues and organs, leading to secondary metastasis through the circulation of blood and fluids.
According to the statistic provided by the American Cancer Society, in the US 2019, approximately 1,762,450 new cancer cases will be diagnosed and 606,880 deaths are results of cancer.
Furthermore, in the age perspective, older adults although are accounted for only 8% of all cases diagnosed in the US, have a 17% mortality rate compared to other age groups.
The 5 years survival rate is totally depending on the stage of cancer diagnosed. The early diagnosed stage has the highest survival rate compared to other later stages.
Many risk factors such as aging, tobacco, sun exposure, toxic exposure, viruses and bacteria, use hormone therapy, family history of cancer, alcohol, poor diet, lack of physical activity, or being overweight have been found to increase the risk of cancer, epidemiologically.
However, most people with some of the aforementioned risk factors have never developed cancer.
Some researchers in the examination of the risk of obesity in risk cancer wrote, "The prevalence of overweight and obesity is increasing worldwide, and the evidence base for a link between obesity and cancer is growing... Recent research has found that as the body mass index increases by 5 kg/m2, cancer mortality increases by 10%".
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
The research team at the University of Oxford on finding a potential compound for the treatment of cancer with no side effects examined the bromelain capacity against cancers in the past and present studies.
Evidence derived from clinical observations, mouse- and cell-based models suggested that bromelain, a 95%-mixture of proteases acts systemically, affecting multiple cellular and molecular targets.
The most recent study found that bromelain has the capacity to inhibit cell malignancy by modulating the key pathways associated with cell differentiation.
Other studies suggested the anti-cancer activity of bromelain consists of the direct impact on cancer cells and their microenvironment by modulating immune, inflammatory and hemostatic systems.
Additionally, in the study to reaffirm the use of bromelain (BL) as an anti-cancer phytotherapeutic agent, researchers examined the Oral administration of bromelain (BL) in anti-cancer drugs encapsulated in Poly(lactic-co-glycolic acid) (PLGA) to formulate nanoparticles (NPs).
NPs enhanced the function of cytotoxicity in the induction of cancer cell death in the significant dose advantage (-7-10 folds) that reduces the IC50 values, compared to free BL.
NPs induced cellular uptake of MCF-7, HeLa and Caco-2 cells monolayer by several folds compared to free BL.
NPs also modulated the expression of marker proteins associated with apoptosis and cell death and suppression (P53, P21, Bcl2, Bax).
Furthermore, in Swiss albino mice, NPs injection not only reduced the tumor burden of Ehrlich ascites carcinoma (EAC) but also increased their life-span (160.0 ± 5.8%) compared to free BL.
In other words, NPs enhanced anti-carcinogenic potential through a number of mechanisms, including the generation of reactive oxygen species, induction of apoptosis and impaired mitochondrial membrane potential.
Taken altogether, bromelain used alone or encapsulated in Poly(lactic-co-glycolic acid) (PLGA) may be considered supplements for the prevention and treatment of cancer, pending to the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Bromelain's activity and potential as an anti-cancer agent: Current evidence and perspectives by Chobotova K1, Vernallis AB, Majid FA. (PubMed)
(2) Anti-cancer activity of bromelain nanoparticles by oral administration by Bhatnagar P, Patnaik S, Srivastava AK, Mudiam MK, Shukla Y, Panda AK, Pant AB, Kumar P, Gupta KC. (PubMed)
(3) Obesity and Cancer Risk: Recent Review and Evidence by Karen Basen-Engquist
and Maria Chang. (PMC)
Most cases of cancer start in the cells on the surface of the inner lining of specific tissues and organs.
At the early stage due to the very small size of the tumor, most cancers are asymptomatic. However, at the advanced stage, cancer only can induce general symptoms such as gastrointestinal discomfort, unintended weight loss, fatigue, and loss but also lead to specific symptoms, such as localized bleeding and pain, depending on the location of cancer.
Also, at this stage, primary cancer cells can travel a distance away from the original site to infect other healthy tissues and organs, leading to secondary metastasis through the circulation of blood and fluids.
According to the statistic provided by the American Cancer Society, in the US 2019, approximately 1,762,450 new cancer cases will be diagnosed and 606,880 deaths are results of cancer.
Furthermore, in the age perspective, older adults although are accounted for only 8% of all cases diagnosed in the US, have a 17% mortality rate compared to other age groups.
The 5 years survival rate is totally depending on the stage of cancer diagnosed. The early diagnosed stage has the highest survival rate compared to other later stages.
Many risk factors such as aging, tobacco, sun exposure, toxic exposure, viruses and bacteria, use hormone therapy, family history of cancer, alcohol, poor diet, lack of physical activity, or being overweight have been found to increase the risk of cancer, epidemiologically.
However, most people with some of the aforementioned risk factors have never developed cancer.
Some researchers in the examination of the risk of obesity in risk cancer wrote, "The prevalence of overweight and obesity is increasing worldwide, and the evidence base for a link between obesity and cancer is growing... Recent research has found that as the body mass index increases by 5 kg/m2, cancer mortality increases by 10%".
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
The research team at the University of Oxford on finding a potential compound for the treatment of cancer with no side effects examined the bromelain capacity against cancers in the past and present studies.
Evidence derived from clinical observations, mouse- and cell-based models suggested that bromelain, a 95%-mixture of proteases acts systemically, affecting multiple cellular and molecular targets.
The most recent study found that bromelain has the capacity to inhibit cell malignancy by modulating the key pathways associated with cell differentiation.
Other studies suggested the anti-cancer activity of bromelain consists of the direct impact on cancer cells and their microenvironment by modulating immune, inflammatory and hemostatic systems.
Additionally, in the study to reaffirm the use of bromelain (BL) as an anti-cancer phytotherapeutic agent, researchers examined the Oral administration of bromelain (BL) in anti-cancer drugs encapsulated in Poly(lactic-co-glycolic acid) (PLGA) to formulate nanoparticles (NPs).
NPs enhanced the function of cytotoxicity in the induction of cancer cell death in the significant dose advantage (-7-10 folds) that reduces the IC50 values, compared to free BL.
NPs induced cellular uptake of MCF-7, HeLa and Caco-2 cells monolayer by several folds compared to free BL.
NPs also modulated the expression of marker proteins associated with apoptosis and cell death and suppression (P53, P21, Bcl2, Bax).
Furthermore, in Swiss albino mice, NPs injection not only reduced the tumor burden of Ehrlich ascites carcinoma (EAC) but also increased their life-span (160.0 ± 5.8%) compared to free BL.
In other words, NPs enhanced anti-carcinogenic potential through a number of mechanisms, including the generation of reactive oxygen species, induction of apoptosis and impaired mitochondrial membrane potential.
Taken altogether, bromelain used alone or encapsulated in Poly(lactic-co-glycolic acid) (PLGA) may be considered supplements for the prevention and treatment of cancer, pending to the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Bromelain's activity and potential as an anti-cancer agent: Current evidence and perspectives by Chobotova K1, Vernallis AB, Majid FA. (PubMed)
(2) Anti-cancer activity of bromelain nanoparticles by oral administration by Bhatnagar P, Patnaik S, Srivastava AK, Mudiam MK, Shukla Y, Panda AK, Pant AB, Kumar P, Gupta KC. (PubMed)
(3) Obesity and Cancer Risk: Recent Review and Evidence by Karen Basen-Engquist
and Maria Chang. (PMC)
Artichoke Protects the Brian Neurons Against Learning and Memory Impairment
Learning is an action of acquired skill or knowledge in a short or lifelong process.
Memory is a process that stores the acquired knowledge expressed to them when they are needed.
In other words, learning and memory is a process involved different stages including acquisition, consolidation, and retrieval.
There are many causes of neuron loss in facilitating the onset of learning and memory impairment. In fact, neuronal apoptosis has been reported to play a key role in the impairment of learning and memory processes.
Several toxins such as scopolamine, streptozotocin, quinolinic acid, and domoic acid have been found to utilize based on their mechanism of action for learning and memory impairment.
Toxins induced amyloid-β deposits are known to cause specific learning and memory impairment in patients with Parkinson's disease dementia and Alzheimer's disease dementia.
Environmental pollutants, such as botulinum, and lipopolysaccharide are also considered various classes of neurotoxin models for learning and memory impairment.
Although the increase in aging has been well known to be a major factor in the initiation of the learning and memory impairment in patients with neurodegenerative disease, the genetic mutation also has a strong implication on cognitive functions that can lead to either impairment in learning and memory.
Dr. Niu Q, the lead scientist, in the assessment of the acquired genetic mutation in patients with learning and memory impairment said, "Neuronal apoptosis has become a focus of interest, as it has been reported to play a key role in the impairment of learning and memory processes (Thompson, Science 267:1456, 1995). The Bcl-2 gene acts as an important effector for inhibiting apoptosis".
"Neuronal apoptosis was extensive in the brain of Al-exposed groups, and the expressions of Bcl-2 protein in the frontal cortex, cerebellum, and hippocampus of Al-exposed rats were stronger... and chronic Al-exposure in rats is associated with neuronal apoptosis in the brain, and impaired learning and memory. Augmented Bcl-2 protein expression may be a stimulated compensatory mechanism".
The findings strongly suggested that gene alternation due to long-term exposure to a toxic chemical cause gradual loss and death neurons, leading to learning and memory impairment.
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine for as liver protective and detoxified agents, and to treat digestive disorders, abdominal pain gas and bloating, etc.
Researchers on the finding a natural therapeutics for the treatment of learning and memory impairment investigated the Stachys sieboldii (Chinese artichoke) neuroprotective effects of S. sieboldii tuber extract in alleviating learning and memory dysfunction associated with vascular dementia or Alzheimer's disease.
Ginkgo biloba leaf extract (ginkgo extract) used as a positive control. Mice were subjected to bilateral carotid artery occlusion (BCAO) for 30 min.
Oral administration of chorogi or ginkgo extracts significantly reduced post-ischemic glucose intolerance on day 1 and neuronal damage including memory impairment on day 3 after BCAO without affecting the locomotor activity.
Furthermore, both chorogi or ginkgo extract insignificantly alleviated scopolamine-induced learning and memory impairments.
In primary neurons, the neuronal survival rate was significantly reduced by hydrogen peroxide was significantly suppressed by chorogi extract and ginkgo extract.
These results suggested, chorogi or ginkgo extract protected the integrity and viability of the neurons by inhibiting the overexpression of free radicals through improving the antioxidant enzymes produced by the mice.
Researchers at the final report wrote. "chorogi extract, as well as ginkgo extract, can protect against learning and memory dysfunction associated with ischemic brain injury through an antioxidative mechanism".
Taken altogether, artichoke may be considered a functional remedy for the prevention and treatment of p learning and memory impairment with no side effects, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Stachys sieboldii (Labiatae, Chorogi) Protects against Learning and MemoryDysfunction Associated with Ischemic Brain Injury by Harada S1, Tsujita T, Ono A, Miyagi K, Mori T, Tokuyama S. (PubMed)
(2) Toxin-Induced Experimental Models of Learning and Memory Impairment by More SV1, Kumar H2, Cho DY3, Yun YS4, Choi DK. (PubMed)
(3) The relationship between Bcl-gene expression and learning and memory impairment in chronic aluminum-exposed rats by Niu Q1, Yang Y, Zhang Q, Niu P, He S, Di Gioacchino M, Conti P, Boscolo P. (PubMed)
Memory is a process that stores the acquired knowledge expressed to them when they are needed.
In other words, learning and memory is a process involved different stages including acquisition, consolidation, and retrieval.
There are many causes of neuron loss in facilitating the onset of learning and memory impairment. In fact, neuronal apoptosis has been reported to play a key role in the impairment of learning and memory processes.
Several toxins such as scopolamine, streptozotocin, quinolinic acid, and domoic acid have been found to utilize based on their mechanism of action for learning and memory impairment.
Toxins induced amyloid-β deposits are known to cause specific learning and memory impairment in patients with Parkinson's disease dementia and Alzheimer's disease dementia.
Environmental pollutants, such as botulinum, and lipopolysaccharide are also considered various classes of neurotoxin models for learning and memory impairment.
Although the increase in aging has been well known to be a major factor in the initiation of the learning and memory impairment in patients with neurodegenerative disease, the genetic mutation also has a strong implication on cognitive functions that can lead to either impairment in learning and memory.
Dr. Niu Q, the lead scientist, in the assessment of the acquired genetic mutation in patients with learning and memory impairment said, "Neuronal apoptosis has become a focus of interest, as it has been reported to play a key role in the impairment of learning and memory processes (Thompson, Science 267:1456, 1995). The Bcl-2 gene acts as an important effector for inhibiting apoptosis".
"Neuronal apoptosis was extensive in the brain of Al-exposed groups, and the expressions of Bcl-2 protein in the frontal cortex, cerebellum, and hippocampus of Al-exposed rats were stronger... and chronic Al-exposure in rats is associated with neuronal apoptosis in the brain, and impaired learning and memory. Augmented Bcl-2 protein expression may be a stimulated compensatory mechanism".
The findings strongly suggested that gene alternation due to long-term exposure to a toxic chemical cause gradual loss and death neurons, leading to learning and memory impairment.
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine for as liver protective and detoxified agents, and to treat digestive disorders, abdominal pain gas and bloating, etc.
Researchers on the finding a natural therapeutics for the treatment of learning and memory impairment investigated the Stachys sieboldii (Chinese artichoke) neuroprotective effects of S. sieboldii tuber extract in alleviating learning and memory dysfunction associated with vascular dementia or Alzheimer's disease.
Ginkgo biloba leaf extract (ginkgo extract) used as a positive control. Mice were subjected to bilateral carotid artery occlusion (BCAO) for 30 min.
Oral administration of chorogi or ginkgo extracts significantly reduced post-ischemic glucose intolerance on day 1 and neuronal damage including memory impairment on day 3 after BCAO without affecting the locomotor activity.
Furthermore, both chorogi or ginkgo extract insignificantly alleviated scopolamine-induced learning and memory impairments.
In primary neurons, the neuronal survival rate was significantly reduced by hydrogen peroxide was significantly suppressed by chorogi extract and ginkgo extract.
These results suggested, chorogi or ginkgo extract protected the integrity and viability of the neurons by inhibiting the overexpression of free radicals through improving the antioxidant enzymes produced by the mice.
Researchers at the final report wrote. "chorogi extract, as well as ginkgo extract, can protect against learning and memory dysfunction associated with ischemic brain injury through an antioxidative mechanism".
Taken altogether, artichoke may be considered a functional remedy for the prevention and treatment of p learning and memory impairment with no side effects, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Stachys sieboldii (Labiatae, Chorogi) Protects against Learning and MemoryDysfunction Associated with Ischemic Brain Injury by Harada S1, Tsujita T, Ono A, Miyagi K, Mori T, Tokuyama S. (PubMed)
(2) Toxin-Induced Experimental Models of Learning and Memory Impairment by More SV1, Kumar H2, Cho DY3, Yun YS4, Choi DK. (PubMed)
(3) The relationship between Bcl-gene expression and learning and memory impairment in chronic aluminum-exposed rats by Niu Q1, Yang Y, Zhang Q, Niu P, He S, Di Gioacchino M, Conti P, Boscolo P. (PubMed)
Herbal Arnica, The Functional Herb Which Stops the Onset of Chronic Diseases Associated with Oxidative Stress, Researchers Found
Arnica may have a profound and therapeutic effect in reducing the risk of diseases associated with overexpression oxidative stress, some scientists suggested.
The expression of oxidative stress is a medical condition characterized by the imbalance of the ratio of free radicals and antioxidant enzymes produced by the host tissue.
In some cases, this reaction also is caused long-term accumulation of toxic substances in the body, such as lead, cadmium, mercury, and arsenic.
Dr. Ercal N, the lead author in the study of the relation of toxic metals and oxidative stress, wrote, "antioxidants may play an important role in abating some hazards of heavy metals. In order to prove the importance of using antioxidants in heavy metal poisoning, pertinent biochemical mechanisms for metal-induced oxidative stress".
There is no single cause of oxidative stress. Some researchers suggested that a number of factors can facilitate the onset of oxidative stress, including cigarette smoke, oxidative burst from activated macrophages, particularly, the free radicals chain reaction.
Sadly, a prolonged period of oxidative stress presented in the human body can cause oxidative damage to biomolecules, (lipids, proteins, DNA) and the death of healthy cells through cytotoxicity.
Certain chronic diseases are found to be associated with oxidative stress, including atherosclerosis, cancer, diabetics, rheumatoid arthritis, post-ischemic perfusion injury, myocardial infarction, cardiovascular diseases, chronic inflammation, and stroke.
By changing diet and lifestyle, oxidative stress can be managed or avoided, Dr. Seungyoun Jung, the lead author in the study of Healthy Dietary Patterns and Oxidative Stress suggested, "Healthy diets may lower oxidative stress and risk of chronic diseases" and "Among specific food groups that contribute to these diet scores, significantly positive associations were observed with legumes and vegetables for FlOP_360, vegetables and fruits for FlOP_320, and legumes and alcohol for FlOP_400".
Where fluorescent oxidation products (FlOP) is a global marker of oxidative stress
Arnica is a herbaceous species, genus perennial, belonging to the family Asteraceae, native to Europe and Asia.
Herbal medicine used in herbal medicine for centuries to treat strains, sprains, and bruises.
The ingredients
Helenalin, chamissonolid, Sesquiterpene lactone, lignans of the furofuran, dibenzylbutyrolactone, dibenzylbutyrolactol types, pinoresinol, epipinoresinol, phillygenin, matairesinol, nortrachelogenin, and nortracheloside, six dibenzylbutyrolactol derivatives.
In the analysis of the effect of Arnica Arnica on mitochondrial oxidative stress induced by Ca(2+) plus inorganic phosphate and/or Fe(2+)-citrate-mediated lipid peroxidation through changes in oxygen consumption rates in adult male Wistar rat, researchers found that application of Arnica at dose of 6cH, 12cH, 30cH or succussed 30% ethanol (control) for 21 days, exert a strong activity in reduced expression of lipid peroxidation of mitochondrial membranes through inhibiting the antimycin-A, a toxic chemical with function in initiated production of free radicals.
Under oxidative stress conditions caused by the injection of Ca(2+) and inorganic phosphate, tested group with a dose of Arnica 30cH demonstrated the effect in decreasing mitochondrial O(2), an indication of lesser expression of free radicals presented in the mitochondrion, through the herbal antioxidant activity.
In liver tissues, administration of Anise at dose 30cH in the tested group also protected the hepatic mitochondrial membrane permeabilization by inhibited ROS on the induction of lipid peroxidation and precipitated fragmentation of proteins.
Further evaluation of the study showed that these results of free radical inhibitory effect were attributed to levels of antioxidants from the herb and the herb in the stimulated production of antioxidants of the tested host.
Additionally, in the investigate the therapeutic effects and mechanism of action of A. Montana flower methanol extract (AMME) against both inflammation and oxidative stress in a collagen-induced arthritis (CIA) rat model, scientists suggested that oral administration of AMME reduces clinical signs and improves the histological and radiological status of the hind limb joints, through reducing overexpression of levels of nitric oxide, tumor necrosis factor-α, interleukins (IL-1β, IL-6, and IL-12) and titer of anti-type II collagen antibody activated by high levels of oxidative stress.
This inhibitory effect of AMME against overproduction inflammatory factors not only reverses the disturbed antioxidant levels and peroxidative damage but also inhibits the overproduction of inflammatory cytokines in facilitated cell damage and healthy cell death at the site of infection.
Moreover, according to the gas chromatography/mass spectrometry (GC/MS) analysis, the function of Arnica in the alleviation of arthritis by ameliorating ROS expression was attributed to the combined action of phenolic and flavonoid compounds.
Dr. Sharma S, the lead author said, " The study also shed some light on mechanisms involved in the diminution of inflammatory mediators and free radical-generating toxicants and enhancement of the antioxidant armory, thereby preventing further tissue damage, injury and synovial hyperproliferation in arthritis".
The above differentiation was supported by the National Institute of Research and Development for Biological Sciences study of A. montana and A. absinthium ethanolic extracts antioxidant activity and protective effect against H2O2-induced oxidative stress in a mouse fibroblast-like NCTC cell line.
According to the final assessment, researchers suggested that both A. absinthium and A. montana extract showed a strong antioxidant capacity but lesser in A. montana, compared to A. absinthium.
At the doses of the range of 10-100 mg/L and A. montana and 10-500 mg/L A. absinthium, both extracts exhibited a significant oxygen radical absorbance capacity and 2,2-diphenyl-1-picrylhydrazyl free radical-scavenging activity and protected fibroblast cells against hydrogen peroxide-induced oxidative damage, depending on the levels of flavonoids and phenolic acids contents presented in the extracts.
According to the neutral red and lactate dehydrogenase assays, pretreatment with 10 mg/L A. montana and 10-300 mg/L A. absinthium was considered the best protection against the early onset of ROS production in H2O2-induced oxidative stress in a mouse fibroblast-like NCTC cell line.
Importantly, pre-treatment with A. montana and A. absinthium extracts also restored the proportion of cells in each phase of the cell cycle through inhibiting oxidative stress in the induction of cytotoxicity.
Taken together, Arnica and its bioactive chemical may be considered a functional food in reduced inflammatory-related diseases caused by overexpression of oxidative stress. However, the intake of Arnica supplements should be taken with extreme care for the prevention of acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effect of the oral administration homeopathic Arnica montana on mitochondrial oxidative stress by de Camargo RA1, da Costa ED, Catisti R.(PubMed)
(2) Cumulative therapeutic effects of phytochemicals in Arnica montana flower extract alleviated collagen-induced arthritis: inhibition of both pro-inflammatory mediators and oxidative stress by Sharma S1, Arif M1, Nirala RK1, Gupta R2, Thakur SC(PubMed)
(3) Evaluation of antioxidant and cytoprotective activities of Arnica montana L. and Artemisia absinthium L. ethanolic extracts by Craciunescu O1, Constantin D, Gaspar A, Toma L, Utoiu E, Moldovan L.(PubMed)
(4) Toxic metals and oxidative stress part I: mechanisms involved in metal-induced oxidative damage by Ercal N1, Gurer-Orhan H, Aykin-Burns N.(PubMed)
(5) Healthy Dietary Patterns and Oxidative Stress as Measured by Fluorescent Oxidation Products in Nurses’ Health Study by Seungyoun Jung,1,2,3,* Stephanie A. Smith-Warner,1,2 Walter C. Willett,1,2,4 Molin Wang,2Tianying Wu,5 Majken Jensen,2,4 Susan E. Hankinson,4,6 and A. Heather Eliassen. (PMC)
The expression of oxidative stress is a medical condition characterized by the imbalance of the ratio of free radicals and antioxidant enzymes produced by the host tissue.
In some cases, this reaction also is caused long-term accumulation of toxic substances in the body, such as lead, cadmium, mercury, and arsenic.
Dr. Ercal N, the lead author in the study of the relation of toxic metals and oxidative stress, wrote, "antioxidants may play an important role in abating some hazards of heavy metals. In order to prove the importance of using antioxidants in heavy metal poisoning, pertinent biochemical mechanisms for metal-induced oxidative stress".
There is no single cause of oxidative stress. Some researchers suggested that a number of factors can facilitate the onset of oxidative stress, including cigarette smoke, oxidative burst from activated macrophages, particularly, the free radicals chain reaction.
Sadly, a prolonged period of oxidative stress presented in the human body can cause oxidative damage to biomolecules, (lipids, proteins, DNA) and the death of healthy cells through cytotoxicity.
Certain chronic diseases are found to be associated with oxidative stress, including atherosclerosis, cancer, diabetics, rheumatoid arthritis, post-ischemic perfusion injury, myocardial infarction, cardiovascular diseases, chronic inflammation, and stroke.
By changing diet and lifestyle, oxidative stress can be managed or avoided, Dr. Seungyoun Jung, the lead author in the study of Healthy Dietary Patterns and Oxidative Stress suggested, "Healthy diets may lower oxidative stress and risk of chronic diseases" and "Among specific food groups that contribute to these diet scores, significantly positive associations were observed with legumes and vegetables for FlOP_360, vegetables and fruits for FlOP_320, and legumes and alcohol for FlOP_400".
Where fluorescent oxidation products (FlOP) is a global marker of oxidative stress
Arnica is a herbaceous species, genus perennial, belonging to the family Asteraceae, native to Europe and Asia.
Herbal medicine used in herbal medicine for centuries to treat strains, sprains, and bruises.
The ingredients
Helenalin, chamissonolid, Sesquiterpene lactone, lignans of the furofuran, dibenzylbutyrolactone, dibenzylbutyrolactol types, pinoresinol, epipinoresinol, phillygenin, matairesinol, nortrachelogenin, and nortracheloside, six dibenzylbutyrolactol derivatives.
In the analysis of the effect of Arnica Arnica on mitochondrial oxidative stress induced by Ca(2+) plus inorganic phosphate and/or Fe(2+)-citrate-mediated lipid peroxidation through changes in oxygen consumption rates in adult male Wistar rat, researchers found that application of Arnica at dose of 6cH, 12cH, 30cH or succussed 30% ethanol (control) for 21 days, exert a strong activity in reduced expression of lipid peroxidation of mitochondrial membranes through inhibiting the antimycin-A, a toxic chemical with function in initiated production of free radicals.
Under oxidative stress conditions caused by the injection of Ca(2+) and inorganic phosphate, tested group with a dose of Arnica 30cH demonstrated the effect in decreasing mitochondrial O(2), an indication of lesser expression of free radicals presented in the mitochondrion, through the herbal antioxidant activity.
In liver tissues, administration of Anise at dose 30cH in the tested group also protected the hepatic mitochondrial membrane permeabilization by inhibited ROS on the induction of lipid peroxidation and precipitated fragmentation of proteins.
Further evaluation of the study showed that these results of free radical inhibitory effect were attributed to levels of antioxidants from the herb and the herb in the stimulated production of antioxidants of the tested host.
Additionally, in the investigate the therapeutic effects and mechanism of action of A. Montana flower methanol extract (AMME) against both inflammation and oxidative stress in a collagen-induced arthritis (CIA) rat model, scientists suggested that oral administration of AMME reduces clinical signs and improves the histological and radiological status of the hind limb joints, through reducing overexpression of levels of nitric oxide, tumor necrosis factor-α, interleukins (IL-1β, IL-6, and IL-12) and titer of anti-type II collagen antibody activated by high levels of oxidative stress.
This inhibitory effect of AMME against overproduction inflammatory factors not only reverses the disturbed antioxidant levels and peroxidative damage but also inhibits the overproduction of inflammatory cytokines in facilitated cell damage and healthy cell death at the site of infection.
Moreover, according to the gas chromatography/mass spectrometry (GC/MS) analysis, the function of Arnica in the alleviation of arthritis by ameliorating ROS expression was attributed to the combined action of phenolic and flavonoid compounds.
Dr. Sharma S, the lead author said, " The study also shed some light on mechanisms involved in the diminution of inflammatory mediators and free radical-generating toxicants and enhancement of the antioxidant armory, thereby preventing further tissue damage, injury and synovial hyperproliferation in arthritis".
The above differentiation was supported by the National Institute of Research and Development for Biological Sciences study of A. montana and A. absinthium ethanolic extracts antioxidant activity and protective effect against H2O2-induced oxidative stress in a mouse fibroblast-like NCTC cell line.
According to the final assessment, researchers suggested that both A. absinthium and A. montana extract showed a strong antioxidant capacity but lesser in A. montana, compared to A. absinthium.
At the doses of the range of 10-100 mg/L and A. montana and 10-500 mg/L A. absinthium, both extracts exhibited a significant oxygen radical absorbance capacity and 2,2-diphenyl-1-picrylhydrazyl free radical-scavenging activity and protected fibroblast cells against hydrogen peroxide-induced oxidative damage, depending on the levels of flavonoids and phenolic acids contents presented in the extracts.
According to the neutral red and lactate dehydrogenase assays, pretreatment with 10 mg/L A. montana and 10-300 mg/L A. absinthium was considered the best protection against the early onset of ROS production in H2O2-induced oxidative stress in a mouse fibroblast-like NCTC cell line.
Importantly, pre-treatment with A. montana and A. absinthium extracts also restored the proportion of cells in each phase of the cell cycle through inhibiting oxidative stress in the induction of cytotoxicity.
Taken together, Arnica and its bioactive chemical may be considered a functional food in reduced inflammatory-related diseases caused by overexpression of oxidative stress. However, the intake of Arnica supplements should be taken with extreme care for the prevention of acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effect of the oral administration homeopathic Arnica montana on mitochondrial oxidative stress by de Camargo RA1, da Costa ED, Catisti R.(PubMed)
(2) Cumulative therapeutic effects of phytochemicals in Arnica montana flower extract alleviated collagen-induced arthritis: inhibition of both pro-inflammatory mediators and oxidative stress by Sharma S1, Arif M1, Nirala RK1, Gupta R2, Thakur SC(PubMed)
(3) Evaluation of antioxidant and cytoprotective activities of Arnica montana L. and Artemisia absinthium L. ethanolic extracts by Craciunescu O1, Constantin D, Gaspar A, Toma L, Utoiu E, Moldovan L.(PubMed)
(4) Toxic metals and oxidative stress part I: mechanisms involved in metal-induced oxidative damage by Ercal N1, Gurer-Orhan H, Aykin-Burns N.(PubMed)
(5) Healthy Dietary Patterns and Oxidative Stress as Measured by Fluorescent Oxidation Products in Nurses’ Health Study by Seungyoun Jung,1,2,3,* Stephanie A. Smith-Warner,1,2 Walter C. Willett,1,2,4 Molin Wang,2Tianying Wu,5 Majken Jensen,2,4 Susan E. Hankinson,4,6 and A. Heather Eliassen. (PMC)
Herbal Ashwagandha Processes Lowering Cholesterol Property
Cholesterol produced by the liver plays an essential role in moderate amount in orchestrating the production of steroid hormone and vitamin D, building strong cell walls and aiding the digestive system in absorbing nutrients and fluids.
Hyperlipidemia or high blood cholesterol is a medical condition characterized by abnormally high levels of lipids in the blood.
Blood cholesterol can be classified into
* The high-density lipoprotein is also known as good cholesterol processes a function to return cholesterol to the liver.
* The low-density lipoprotein is also known as "bad" cholesterol processed a function aforementioned health benefits in moderate amount.
In a healthy individual, unused cholesterol is returned to the liver. However, overexpression of "bad" cholesterol due to the consumption of a high-fat diet and reduced levels of "good" cholesterol can cause bad cholesterol remaining in the bloodstream, leading to hyperlipidemia.
The healthy ratio of total blood cholesterol ("bad"/ "good") is any numbers that are less than 4.
Patients with hyperlipidemia are assymptomatic. However, over time hyperlipidemia can cause plaque accumulated on the arterial wall, leading to atherosclerosis, a major cause of heart disease and stroke.
According to the statistics provided by the CDC, in 2015–2016, more than 12% of adults age 20 and older had total cholesterol higher than 240 mg/dL, and more than 18% had high-density lipoprotein (HDL, or “good”) cholesterol levels less than 40 mg/dL in the US.
Some researchers suggested that the hyperlipidemic prevalence in the Western world may correlate to the promotion of a high-fat diet over the past few decades.
Dr. Karam I, the lead scientist in examing the said, "Hyperlipidemia, a group of metabolic disorders characterized by the elevated levels of lipids, is a major modifiable risk factor for atherosclerosis and cardiovascular disease [5]. These lipids include cholesterol, cholesterol esters, phospholipids, and triglycerides. Increased levels of LDL are related to the development of atherosclerosis [15,16].
And, "The result showed that there was a significant increase in hyperlipidemia biomarker which includes TC, TG, LDL, and HDL. There were histological changes in organs which confirm the previous result of blood lipid. That mean high fat diet successfully induces hyperlipidemia in rats, to make disease model of hyperlipidemia.".
The life-long condition of hyperlipidemia is treatable. By a change of diet and daily moderate exercise, you may control the condition without medication.
Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.
The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
On finding a potent compound for the treatment of heart disease, researchers examined the effects of Ashwagandha on lowering blood cholesterol.
The study included rats induced by a high-fat diet treated by aqueous extract of fruits of Withania coagulans for 7 weeks.
According to the tested analysis during the experiment, administration of the extract showed a significantly reduced elevated serum cholesterol, triglycerides and lipoprotein levels.
In triton induced hypercholesterolemia., the aqueous extract of fruits of Withania coagulans exerted a significantly hypolipidemic activity.
Furthermore, according to the tested analysis on the liver tissues of treated hyperlipidemic rats, the extracts also inhibited the degenerative changes, compared to hyperlipidemic controls.
Based on the findings, researchers said, "The hypolipidemic effect of W. coagulans fruits was found to be comparable to that of an Ayurvedic product containing Commiphora mukkul".
Taken altogether, Ashwagandha may be considered a functional herb for lowering blood cholesterol, pending to the result of larger sample size and multicenter study
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Hypolipidemic and antioxidant activity of aqueous extract of fruit of Withaniacoagulans (Stocks) Dunal in cholesterol-fed hyperlipidemic rabbit model by Shukla K, Dikshit P, Shukla R, Sharma S, Gambhir JK. (PubMed)
(2) Hypolipidemic activity of aqueous extract of Withania coagulans Dunal in albino rats by Hemalatha S1, Wahi AK, Singh PN, Chansouria JP. (PubMed)
(2) Induce Hyperlipidemia in Rats Using High Fat Diet Investigating Blood Lipid and Histopathology by Karam I, Ma N, Yang Y-J, and Li J-Y. (The Journal of Hematology and Blood Disorders)
Hyperlipidemia or high blood cholesterol is a medical condition characterized by abnormally high levels of lipids in the blood.
Blood cholesterol can be classified into
* The high-density lipoprotein is also known as good cholesterol processes a function to return cholesterol to the liver.
* The low-density lipoprotein is also known as "bad" cholesterol processed a function aforementioned health benefits in moderate amount.
In a healthy individual, unused cholesterol is returned to the liver. However, overexpression of "bad" cholesterol due to the consumption of a high-fat diet and reduced levels of "good" cholesterol can cause bad cholesterol remaining in the bloodstream, leading to hyperlipidemia.
The healthy ratio of total blood cholesterol ("bad"/ "good") is any numbers that are less than 4.
Patients with hyperlipidemia are assymptomatic. However, over time hyperlipidemia can cause plaque accumulated on the arterial wall, leading to atherosclerosis, a major cause of heart disease and stroke.
According to the statistics provided by the CDC, in 2015–2016, more than 12% of adults age 20 and older had total cholesterol higher than 240 mg/dL, and more than 18% had high-density lipoprotein (HDL, or “good”) cholesterol levels less than 40 mg/dL in the US.
Some researchers suggested that the hyperlipidemic prevalence in the Western world may correlate to the promotion of a high-fat diet over the past few decades.
Dr. Karam I, the lead scientist in examing the said, "Hyperlipidemia, a group of metabolic disorders characterized by the elevated levels of lipids, is a major modifiable risk factor for atherosclerosis and cardiovascular disease [5]. These lipids include cholesterol, cholesterol esters, phospholipids, and triglycerides. Increased levels of LDL are related to the development of atherosclerosis [15,16].
And, "The result showed that there was a significant increase in hyperlipidemia biomarker which includes TC, TG, LDL, and HDL. There were histological changes in organs which confirm the previous result of blood lipid. That mean high fat diet successfully induces hyperlipidemia in rats, to make disease model of hyperlipidemia.".
The life-long condition of hyperlipidemia is treatable. By a change of diet and daily moderate exercise, you may control the condition without medication.
Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.
The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
On finding a potent compound for the treatment of heart disease, researchers examined the effects of Ashwagandha on lowering blood cholesterol.
The study included rats induced by a high-fat diet treated by aqueous extract of fruits of Withania coagulans for 7 weeks.
According to the tested analysis during the experiment, administration of the extract showed a significantly reduced elevated serum cholesterol, triglycerides and lipoprotein levels.
In triton induced hypercholesterolemia., the aqueous extract of fruits of Withania coagulans exerted a significantly hypolipidemic activity.
Furthermore, according to the tested analysis on the liver tissues of treated hyperlipidemic rats, the extracts also inhibited the degenerative changes, compared to hyperlipidemic controls.
Based on the findings, researchers said, "The hypolipidemic effect of W. coagulans fruits was found to be comparable to that of an Ayurvedic product containing Commiphora mukkul".
Taken altogether, Ashwagandha may be considered a functional herb for lowering blood cholesterol, pending to the result of larger sample size and multicenter study
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Hypolipidemic and antioxidant activity of aqueous extract of fruit of Withaniacoagulans (Stocks) Dunal in cholesterol-fed hyperlipidemic rabbit model by Shukla K, Dikshit P, Shukla R, Sharma S, Gambhir JK. (PubMed)
(2) Hypolipidemic activity of aqueous extract of Withania coagulans Dunal in albino rats by Hemalatha S1, Wahi AK, Singh PN, Chansouria JP. (PubMed)
(2) Induce Hyperlipidemia in Rats Using High Fat Diet Investigating Blood Lipid and Histopathology by Karam I, Ma N, Yang Y-J, and Li J-Y. (The Journal of Hematology and Blood Disorders)
Saturday, December 28, 2019
Herbal Artichoke, the Potent Antioxidant
Oxidative stress is a condition caused by the imbalance of the ratio of free radicals and antioxidants produced by the host, leading to lipid and protein damage and alternation of cell DNA.
Oxidative stress has been found to initiate the onset of chronic disease, including heart disease, diabetes, and cancers.
Free radicals are unstable atoms with an unpaired electron in the outer ring. Therefore, in order for them to become stable, free radicals are ready to steal or donate an electron from or to other atoms, leading to a chain reaction that can not be stopped until all electrons in the outer ring are paired or inhibited by antioxidants.
The overexpression of free radicals is bad. However, free radicals generated from cell metabolism may play a critical role in the synthesis of energy and essential molecules and boosting the immune system.
Antioxidants are stable atoms that inhibit oxidation.
In a healthy individual, antioxidant enzymes by the body are more than enough to accounter the expression of free radicals that bombard our body every day.
However, in less healthy people, the intake of dietary antioxidants such as supplements or fruits rich with antioxidants may be the only option to improve levels of antioxidants in the body.
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine as liver protective and detoxified agents, and to treat digestive disorders, abdominal pain gas and bloating, etc.
On finding a natural compound for the treatment of diseases associated with oxidative stress, researchers investigated artichoke antioxidant activity, compared to those of Ficus carica, and Morus nigra and their herbal mixture (CFM) in vitro, using CCl4 induced damage in HepG2 cells.
CFM at 1 mg/ml showed a 47.00% and 37.09% decline of aspartate transaminase and alanine transaminase, the oxidative stress markers and an increase of the glutathione and superoxide dismutase 77.32% and 101.02%, the antioxidants produced by the host, comparable to CCl4 treated cells.
The antioxidant activity of fig and artichoke was attributed to the existence of different phenolic metabolites that act synergistically.
Dr. Youssef FS, the lead scientist said, "a herbal mixture composed of blackberry, artichoke, and fig could afford an excellent natural candidate to combat oxidative stress and counteract hepatic toxins owing to its phenolic compounds".
With an aim to reveal more information about the artichoke antioxidant effects, researchers launched a comprehensive evaluation of the Jerusalem artichoke (Helianthus tuberosus L.) leaf and tuber extract.
According to the results from the analysis, leaf extract exhibited a higher content of phenols and flavonoids comparing to tuber extracts (5.07 and 7.14 fold higher, respectively).
The application of tuber extract at concentrations (25-500 μg·ml- 1) had a positive effect on fibroblast growth.
In the fibroblast cell line, tuber and leaf extracts increase the expression of the ROS SOD-1 inactivating enzyme gene associated with apoptotic signaling and cell death without affecting the levels of Nox-4 antioxidant activity.
Dr. Nizioł-Łukaszewska Z and colleagues, after taking into account co and confounders wrote, "Jerusalem artichoke leaves and tubers extracts affect the cell proliferation and can alter the expression of genes related to oxidative stress".
Taken altogether, artichoke may be considered a functional and herbal remedy for the prevention and treatment of diseases associated with overexpression of reactive oxygen species (ROS), pending to the confirmation of larger sample and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Synergistic Hepatoprotective and Antioxidant Effect of Artichoke, Fig, Blackberry Herbal Mixture on HepG2 Cells and Their Metabolic Profiling Using NMR Coupled with Chemometrics by Youssef FS1, Labib RM1, Eldahshan OA1, Singab ANB. (PubMed)
(2) Antioxidant activity and cytotoxicity of Jerusalem artichoke tubers and leaves extract on HaCaT and BJ fibroblast cells by Nizioł-Łukaszewska Z1, Furman-Toczek D1, Zagórska-Dziok M. (PubMed)
Oxidative stress has been found to initiate the onset of chronic disease, including heart disease, diabetes, and cancers.
Free radicals are unstable atoms with an unpaired electron in the outer ring. Therefore, in order for them to become stable, free radicals are ready to steal or donate an electron from or to other atoms, leading to a chain reaction that can not be stopped until all electrons in the outer ring are paired or inhibited by antioxidants.
The overexpression of free radicals is bad. However, free radicals generated from cell metabolism may play a critical role in the synthesis of energy and essential molecules and boosting the immune system.
Antioxidants are stable atoms that inhibit oxidation.
In a healthy individual, antioxidant enzymes by the body are more than enough to accounter the expression of free radicals that bombard our body every day.
However, in less healthy people, the intake of dietary antioxidants such as supplements or fruits rich with antioxidants may be the only option to improve levels of antioxidants in the body.
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine as liver protective and detoxified agents, and to treat digestive disorders, abdominal pain gas and bloating, etc.
On finding a natural compound for the treatment of diseases associated with oxidative stress, researchers investigated artichoke antioxidant activity, compared to those of Ficus carica, and Morus nigra and their herbal mixture (CFM) in vitro, using CCl4 induced damage in HepG2 cells.
CFM at 1 mg/ml showed a 47.00% and 37.09% decline of aspartate transaminase and alanine transaminase, the oxidative stress markers and an increase of the glutathione and superoxide dismutase 77.32% and 101.02%, the antioxidants produced by the host, comparable to CCl4 treated cells.
The antioxidant activity of fig and artichoke was attributed to the existence of different phenolic metabolites that act synergistically.
Dr. Youssef FS, the lead scientist said, "a herbal mixture composed of blackberry, artichoke, and fig could afford an excellent natural candidate to combat oxidative stress and counteract hepatic toxins owing to its phenolic compounds".
With an aim to reveal more information about the artichoke antioxidant effects, researchers launched a comprehensive evaluation of the Jerusalem artichoke (Helianthus tuberosus L.) leaf and tuber extract.
According to the results from the analysis, leaf extract exhibited a higher content of phenols and flavonoids comparing to tuber extracts (5.07 and 7.14 fold higher, respectively).
The application of tuber extract at concentrations (25-500 μg·ml- 1) had a positive effect on fibroblast growth.
In the fibroblast cell line, tuber and leaf extracts increase the expression of the ROS SOD-1 inactivating enzyme gene associated with apoptotic signaling and cell death without affecting the levels of Nox-4 antioxidant activity.
Dr. Nizioł-Łukaszewska Z and colleagues, after taking into account co and confounders wrote, "Jerusalem artichoke leaves and tubers extracts affect the cell proliferation and can alter the expression of genes related to oxidative stress".
Taken altogether, artichoke may be considered a functional and herbal remedy for the prevention and treatment of diseases associated with overexpression of reactive oxygen species (ROS), pending to the confirmation of larger sample and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Synergistic Hepatoprotective and Antioxidant Effect of Artichoke, Fig, Blackberry Herbal Mixture on HepG2 Cells and Their Metabolic Profiling Using NMR Coupled with Chemometrics by Youssef FS1, Labib RM1, Eldahshan OA1, Singab ANB. (PubMed)
(2) Antioxidant activity and cytotoxicity of Jerusalem artichoke tubers and leaves extract on HaCaT and BJ fibroblast cells by Nizioł-Łukaszewska Z1, Furman-Toczek D1, Zagórska-Dziok M. (PubMed)
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