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Saturday, January 31, 2015

Most common diseases of 50 plus - Diseases of Central Nervous system(CNS): Dementia - Herbal Treatments: Huperzine A

By Kyle J. Norton Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

         Diseases of Central Nervous system

                           Dementia


About 5-8% of all people over the age of 65 have some form of dementia, and this number doubles every five years above that age. Dementia is the loss of mental ability, severe enough to interfere with people's every life and Alzheimer's disease is the most common type of dementia in aging people.

V. Treatments
A. In herbal medicine perspective
4. Huperzine A
Huperzine A, a chemical made from the plant Huperzia serrata have been studied for its effect on patient of dementia with conflict results
1. Cognitive effects
In induced Alzheimer's disease animal study, Huperzine A showed a significant effect in  inhibited acetylcholinesterase, derived from forebrain, hippocampus, cortex and cerebellum(635), through neuron protective effects and enhanced glutamatergic functions(635). In mild to moderate vascular dementia (VaD) patients, The medicine also improved the cognitive function with serious adverse events(636). But according to University of California,, in a phase II trial of huperzine A, regardless to doses, huperzine A did not demonstrate cognitive effect in patients with mild to moderate AD(637). According to Beijing University of Chinese Medicinealthough Huperzine A showed a beneficial effects on improvement of cognitive function, daily living activity in global clinical assessment in participants with Alzheimer's disease, the findings should be interpreted with caution due to the poor methodological quality of the included trials(638).

b. Inhibitiobn of amyloid plaque burden and oligomeric β-amyloid (Aβ)
Huperzine A, showed to reduce in Aβ levels and Aβ burden in AD brain, through activation of  Wnt signaling(regulate cell-to-cell interactions) and targeting of the Wnt/β-catenin signaling pathway in various components in contribution to disease, (639), modulation of amyloidogenic and nonamyloidogenic pathways(640), reduction of iron in the brain(641) via a multi-target mechanism(642).


c. Mild to moderate vascular dementia (VaD) and Alzheimer's disease
In patients with mild to moderate vascular dementia (VaD), Huperzine A significantly improve the cognitive function in mini-mental state examination (MMSE), clinical dementia rating (CDR), and activities of daily living (ADL) scores(643)(644).
In patients with Alzheimer's disease (AD), Huperzine A also showed improvement in memory function and cognitive enhancement at a dose of 0.4 mg using MMSE, MQ, ADAS-COG, and ADL tests(645); against organophosphate (OP) intoxication and  reduction of glutamate-induced cell death(646). According to Georgetown University Hospital, the antioxidant and neuroprotective properties of Huperzine A suggest that it may be useful as a disease-modifying treatment for Alzheimer's disease (AD)(647).
Due to data supporting its use are limited by weak study design, theMassachusetts College of Pharmacy and Health Sciences-Worcester/Manchester suggested that randomized, placebo-controlled trials are necessary to establish the role of huperzine A in the treatment of AD(648).


d. Etc.

References
(635) http://www.ncbi.nlm.nih.gov/pubmed/9141073
(636) http://www.ncbi.nlm.nih.gov/pubmed/21833673
(637) http://www.ncbi.nlm.nih.gov/pubmed/21502597
(638) http://www.ncbi.nlm.nih.gov/pubmed/24086396
(639) http://www.ncbi.nlm.nih.gov/pubmed/?term=Huperzine+A+Wnt%2F%CE%B2-catenin+signaling+pathway
(640) http://www.ncbi.nlm.nih.gov/pubmed/22002568
(641) http://www.ncbi.nlm.nih.gov/pubmed/24332448
(642) http://www.ncbi.nlm.nih.gov/pubmed/15956816
(643) http://www.ncbi.nlm.nih.gov/pubmed/?term=Huperzine+A+and+Mild+to+moderate+vascular+dementia+(VaD)
(644) http://www.ncbi.nlm.nih.gov/pubmed/24639880
(645) http://www.ncbi.nlm.nih.gov/pubmed/21766442
(646) http://www.ncbi.nlm.nih.gov/pubmed/12895686
(647) http://www.ncbi.nlm.nih.gov/pubmed/18230054
(648) http://www.ncbi.nlm.nih.gov/pubmed/19240260

Friday, January 30, 2015

Most common diseases of 50 plus - Diseases of Central Nervous system(CNS): Dementia - The Preventive Phytochemicals Tangeritin and Curcumin

By Kyle J. Norton Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

         Diseases of Central Nervous system

                           Dementia


About 5-8% of all people over the age of 65 have some form of dementia, and this number doubles every five years above that age. Dementia is the loss of mental ability, severe enough to interfere with people's every life and Alzheimer's disease is the most common type of dementia in aging people.
V.  Preventions
C. Phytochemicals Against Dementia
C.4.  Tangeritin
Tangeritin, one of the flavones, is found in tangerine and many citrus peels.
1. Neuroprotective effects
Natural antioxidant tangeretin, may be used as neuroprotective agent, for its significant effects on protection of striato-nigral integrity and functionality in patients with Parkinson's disease(327), probably through its anti-neuroinflammatory activity(328) via mitochondrial depolarization(329) in attenuated reactive oxygen species generation.

2. Antioxidants

Mature and immature calamondin (Citrus mitis Blanco) peel, containing tangeretin showed to exhibit its antioxidant(331) in enhancing the highest oxygen radical absorbance capacity (ORAC) reducing power, and superoxide scavenging effect(330), as well as ameliorating oxidative stress causes of DNA damage(332), mammary carcinoma(333)(334) and diabetes(335).


C.5. Curcumin

Turmeric, principal curcuminoid of the popular Indian spice, is a rhizomatous herbaceous perennial plant of the ginger family, Zingiberaceae, native to tropical South Asia, used in traditional herbal medicine as an anti-inflammatory agent and to treat gastrointestinal symptoms associated with irritable bowel syndrome and other digestive disorders(336). Curcumin, a phytochemical found abundant in the plant, in acidic solutions (pH <7.4) turns yellow, whereas in basic (pH > 8.6) solutions turns bright red.
1. Alzheimer's disease and Anti-inflammatory agent
a. Alzheimer's disease
Increased antioxidant and anti-inflammatory consumption such as curcumin may reduce risk of Alzheimer's disease (AD) caused by amyloid beta (Abeta) accumulation(338) through reversal of Abeta-induced cognitive deficits and neuropathology(339). The phytochemical is also found to disaggregate Abeta in preventing fibril and oligomer formation(338). According to Yamagata University, its synthesized curcumin analogues used pharmateutically in treatment of amyloid β aggregation also experience notable result(337). In vitro and animal models, curcumin was effective, in lowering oxidative damage, cognitive deficits, synaptic marker loss, and amyloid depositio in prevented onset of Alzheimer's disease(340).

b. Anti-inflammatory agent

  Curcumin, an anti-inflammatory agent(341), in the pathogenesis of psoriasis and neurodegenerative diseases,, decreased the expression of pro-inflammatory cells signalling in response to inflammation(342)(343), in patients of ear infection and Parkinson's disease and Alzheimer's disease(344)(345), respectively.

2. Antioxidants

Curcumin also consisting anti-proliferative, anti-inflammatory and immunosuppressive activitie(346), in arthritis, strongly inhibited collagenase and stromely in expression at micromolar concentrations(346); in diabetes, scavenged free radicals and reduced LDL oxidation and cellular oxidative stress(347); in cancers, reduced accumulation of ROS causes of abnormal cells(348), through apoptosis(349); in neurodegenerative diseases, exerted autophagy-lysosomal activities, through removing damaged or dysfunctional proteins and cells with specific function(350) and regulating reactive oxygen species (ROS)(351)(352).
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Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

For over 100 healthy recipes, http://diseases-researches.blogspot.ca/p/blog-page_17.html

References
(327) http://www.ncbi.nlm.nih.gov/pubmed/11726811
(328) http://www.ncbi.nlm.nih.gov/pubmed/24462494
(329) http://www.ncbi.nlm.nih.gov/pubmed/22678994
(330) http://www.ncbi.nlm.nih.gov/pubmed/23194504
(331) http://www.ncbi.nlm.nih.gov/pubmed/20420369
(332) http://www.ncbi.nlm.nih.gov/pubmed/24995432
(333) http://www.ncbi.nlm.nih.gov/pubmed/24299963
(334) http://www.ncbi.nlm.nih.gov/pubmed/25151216
(335) http://www.ncbi.nlm.nih.gov/pubmed/24629597
(336) http://www.sciencedirect.com/science/article/pii/S0308814608009084
(337) http://www.ncbi.nlm.nih.gov/pubmed/2546714
(338) http://www.ncbi.nlm.nih.gov/pubmed/15590663
(339) http://www.ncbi.nlm.nih.gov/pubmed/11755008
(340) http://www.ncbi.nlm.nih.gov/pubmed/25467149
(341) http://www.ncbi.nlm.nih.gov/pubmed/3546166
(342) http://www.ncbi.nlm.nih.gov/pubmed/23825622
(343) http://www.ncbi.nlm.nih.gov/pubmed/25514226
(344) http://www.ncbi.nlm.nih.gov/pubmed/20930270
(345) http://www.ncbi.nlm.nih.gov/pubmed/22426019
(346) http://www.ncbi.nlm.nih.gov/pubmed/16807698
(347) http://www.ncbi.nlm.nih.gov/pubmed/25477660
(348) http://www.ncbi.nlm.nih.gov/pubmed/15700780
(349) http://www.ncbi.nlm.nih.gov/pubmed/25349781
(350) http://www.ncbi.nlm.nih.gov/pubmed/24494187
(351) http://www.ncbi.nlm.nih.gov/pubmed/24335167
(352) http://www.ncbi.nlm.nih.gov/pubmed/24008671

Thursday, January 29, 2015

Most common diseases of 50 plus - Diseases of Central Nervous system(CNS): Dementia - The Preventive Phytochemicals Gingerole and Naringenin

By Kyle J. Norton Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

         Diseases of Central Nervous system

                           Dementia



About 5-8% of all people over the age of 65 have some form of dementia, and this number doubles every five years above that age. Dementia is the loss of mental ability, severe enough to interfere with people's every life and Alzheimer's disease is the most common type of dementia in aging people.
V.  Preventions
C. Phytochemicals Against Dementia
C.2. Gingerole
Gingerole, is also known as gingerol, a phytochemical of Flavonoids (polyphenols) found in fresh ginger. and in variety of other plants. The herb has been used for treatment of nausea and vomiting of pregnancy, motion sickness, rheumatoid arthritis, relieve migraine, etc. in folk medicine.
1. Antioxidant and anti-inflammatory effects
 Chemical constituents of Zingiber officinale Rosc.(Zingiberaceae) showed to attenuate oxidative stress, through its scavenging, and inhibiting superoxide and hydroxyl radicals of ROS species(310), via nephroprotective effect on mediation of oxidative stress, inflammatory processes, and renal dysfunction(311).

2. Dementia

 Ginger(70% aqueous/methanolic extract of dried ginger (Zo.Cr)) beside induced spasmolytic activity in stomach fundus in treating dementia in South Asia, it also inhibited butyrylcholinesterase (BuChE) in improvement of cognitive performance patients with dementia(4) and Vascular dementia (VaD)(315), probably through cholinergic anti-inflammatory pathway in reduced production of amyloid-β(316).

C.3.  Naringenin
Naringenin, a flavanone, belonging to the red, blue, purple pigments of Flavonoids (polyphenols) found predominantly in citrus fruits is considered as one of powerful antioxidant with many health benefits.
1. Antioxidant, free radical scavenging 
 Naringin showed to reduce DNA damage through its antioxidant capacities in scavenging free radicals hydroxyl and superoxide(317). Cognitively, naringenin ameliorates Alzheimer's disease (AD)-type neurodegeneration(318) by improving learning and memory ability of patient with early onset of the diseases(319). Pharmacologically, the phytochemical was found to be a potential anticancer, antimutagenic, anti-inflammatory, antiproliferative and antiatherogenic agent(320).

2. Anti-inflammatory effects(320)
Neuroinflammation is considered as a constant event in Alzheimer's disease (AD), with no evidences for its direct involvement in development(322). In diabetic mice model, naringenin exhibited its anti inflammatory activity in  lowering blood glucose and urea nitrogen, increasing insulin level and creatinine clearance(321), probably through inhibition of iNOS protein and anti inflammatory pathways(323).

3. Immunity

Adaptive and innate immune deficit were shown to associate with cognitive dysfunction in patients with AD and mild cognitive impairment (MCI)(325). Naringenin, stimulated the production T cells in regulating the immune system, in suppression of  allergies and autoimmune diseases(324) which are considered as Alzheimer's and Parkinson's disease variants(326).

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Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

For over 100 healthy recipes, http://diseases-researches.blogspot.ca/p/blog-page_17.html
 
References
(310) http://www.ncbi.nlm.nih.gov/pubmed/19833188
(311) http://www.ncbi.nlm.nih.gov/pubmed/24395230
(312) http://www.ncbi.nlm.nih.gov/pubmed/17487414
(313) http://www.ncbi.nlm.nih.gov/pubmed/25214375
(314) http://www.ncbi.nlm.nih.gov/pubmed/18812031
(315) http://www.ncbi.nlm.nih.gov/pubmed/24727881
(316) http://www.ncbi.nlm.nih.gov/pubmed/24359497
(317) http://www.ncbi.nlm.nih.gov/pubmed/20394007
(318) http://www.ncbi.nlm.nih.gov/pubmed/22898296
(318) http://www.ncbi.nlm.nih.gov/pubmed/25501296
(319) http://www.ncbi.nlm.nih.gov/pubmed/24337945
(320) http://www.ncbi.nlm.nih.gov/pubmed/25501296 
(321) http://www.ncbi.nlm.nih.gov/pubmed/22117528
(322) http://www.ncbi.nlm.nih.gov/pubmed/23841061
(323) http://www.ncbi.nlm.nih.gov/pubmed/18274639
(324) http://www.ncbi.nlm.nih.gov/pubmed/22324845
(325) http://www.ncbi.nlm.nih.gov/pubmed/25201785
(326) http://www.ncbi.nlm.nih.gov/pubmed/24786080

Wednesday, January 28, 2015

Most common diseases of 50 plus - Diseases of Central Nervous system(CNS): Dementia - The Preventive Phytochemical Rosemarinol

By Kyle J. Norton Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

         Diseases of Central Nervous system

                           Dementia



About 5-8% of all people over the age of 65 have some form of dementia, and this number doubles every five years above that age. Dementia is the loss of mental ability, severe enough to interfere with people's every life and Alzheimer's disease is the most common type of dementia in aging people.
V.  Preventions
C. Phytochemicals Against Dementia
A. Rosemarinol

Rosemarinol is a phytochemical monophenols, found in essential oil of labiate herbs like rosemary and in variety of other plants.
1. Retard autoxidation
Rosemary extract rich in carnosic acid showed a significantly retarded autoxidation, in the fish oil undergoes microencapsulation process, according to the North University(307).


2. Anti-inflammatory effects
The extract of rosemary leaves from supercritical fluid extraction showed a high inhibitory effect on lipid peroxidation, through suppression of the LPS-induced production of nitric oxide (NO)(308) and maintaining oxidative stability(313)

3. Antioxidant defenses

 Rosemary extract enhances antioxidant defenses and improves antioxidant status in aged rats in attenuation of lipid peroxidation and ROS levels through its antioxidant enzyme activity(309). The extract also showed to exhibit its antioxidant effect against the proliferation of irregular cell growth such as human leukemia and breast carcinoma cells(312).

Dementia Memory Loss ReversalGuarantee to Stop Progression and Reverse Memory Loss in Alzheimer and  Dementia  with step by step instructions through Scientific Studies  within 2 Months or your Money back

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

For over 100 healthy recipes, http://diseases-researches.blogspot.ca/p/blog-page_17.html

References
(307) http://www.ncbi.nlm.nih.gov/pubmed/21447601
(308) http://www.ncbi.nlm.nih.gov/pubmed/21375325
(309) http://www.ncbi.nlm.nih.gov/pubmed/19289162
(310) http://www.ncbi.nlm.nih.gov/pubmed/19833188
(311) http://www.ncbi.nlm.nih.gov/pubmed/24395230
(312) http://www.ncbi.nlm.nih.gov/pubmed/17487414
(313) http://www.ncbi.nlm.nih.gov/pubmed/25214375

Tuesday, January 27, 2015

recipe9

The Lunch Box, Packed with fun, healthy meals that keep them smiling, byKate McMillan and Sarah Putman Clegg, published by Weldonowen

Fruitwiches: lunchtime eye candy featuring kid.s favorite food group
1. Pear and avocado
mash half ripe avocado in a bowl. Add a squeeze of fresh lemon juice and season to taste with salt and pepper. Spread the avocado evenly on 2 slices of bread. Add layer of thin sliced Bosc or Asian pear to one of the slice. Cover with other slice and press gently to adhere. swap in pomegranate seeds for the pear, if you like.

2. Strawberry and goat cheese
Split an English muffin and lightly toast the halves. Spread the cut side of the bottom half with softened goat cheese or plain whipped cream cheese. Top with a thin layer of strawberry slices. Cover with the top ha;f pf muffin, jam side down and press gently.

3. Honey almond butter and banana
SPREAD 2 SLICES OF WHOLE WHEAT BREAD WITH ALMOND BUTTER OR PEANUT BUTTER. TOP 1 BREAD SLICE WITH DRIZZLE OF HONEY AND A LATER OF BANANA SLICES. COVER WITH OTHER SLICE, BUTTER SIDE DOWN, AND PRESS GENTLY.

4.  Apple cheddar and peanut butter
Split a focaccia square in half in crosswise. Spread the cut side of 1 half with peanut butter. Top with layer of cheddar cheese slices and then a later of thin apple slices. Cover with the other half, cut side down and press gently.
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Rockin' wrap: Fun and flavor-packed handfuls that will be the star of lunch table

5. Hummus and veggie wrap
Spread a flour tortilla or 2 corn tortillas with thin layer of hummus, homemade a purchased. mash a couple of ripe avocado slices on top. Add baby spinach and red bell pepper strips horizontal line across the center. Roll up the tortilla into tight cylinder, either hand-roll style or burrito style.

6. Blt Wrap
Spread a flour tortilla with a thin later of mayo or softened cream cheese. Place 2 strips of cooked applewood-smoked bacon in a horizontal line across the center of the tortilla. Top with bacon ans chopped romaine letter and chopped tomatoes. Roll up the tortilla into tight cylinder, either hand-roll style or burrito style.

7. Pizza wrap
Spread a flour tortilla with a thin later of  pizza sauce or tomato paste. Sprinkle with shredded mozzarella cheese. transfer to a baking sheet lined with foil and bake at 400 degree F (200 degree C) to melt cheese, if you like. Add afew toppings like salami, ham, mushroom, or black olives. Roll up the tortilla into tight cylinder, either hand-roll style or burrito style.


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Stealth side salad: Chunky salad perfect for youngsters who have never to let a shred of lettuce pass their lips

8. Tuna and white bean
In a small container with tight-fitting lid, combine 2 tablespoons olive oil, 1 teaspoon lemon juice and 1é2 teaspoon Dijon mustard. Add equal parts canned white beans, rinsed abd grained and canned tuna, drained and flaked. Sprinkle with minced celery and onion. Cover and shake to combine. Season with salt and pepper.

9. Beet and feta
In a small container with tight-fitting lid, combine 1 tablespoon each olive oil and orange juice and 2 teaspoon balsamic vinegar. Peel and cube 2 roasted beets. Add to the container, cover and shake. Add shredded carrot along with (or in place of) the beets. Sprinkle with feta cheese and season with salt and pepper.

10. Corn and edamame
In a small container with tight-fitting lid, combine 2 teaspoons fresh lime juice and 1 tablespoon olive oil. Add equal parts cooked corn kernels; cooked shelled edamame; halved cherry tomatoes; and avocado cubes. Sprinkle with minced cilantro, if you like. Cover and shake to combine. Season with salt and pepper.

11. Orange and celery
In a small container with tight-fitting lid, combine equal parts sliced or shaved celery and seedless orange segments. Drizzle with / tablespoon olive oil and 1 teaspoon white wine vinegar. Cover and shake gently to combine. Season with salt and papper. Sprinkle with chopped fresh parsley, if you like.

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Cool dips; make- ahead dips that are delicious, diverse and remarkably versatile

12. Peanut-sesame dip
In a bowl, combine 1 tablespoon soy sauce, 2 teaspoons each sesame oil and rice vinegar and 3 tablespoons creamy peanut butter. Whisk in 1-2 tablespoons hot water. Sprinkle with toasted sasame seeds. If you like. make about 1/2 cup (4 fl oz./125 ml).

13. Creamy herb dip
In a blender, combine 1/2 cup (4 fl oz./125 ml), each plain yogurt and cottage cheese; 2 green onion, chopped; 2 teaspoons chopped fresh dill; a handful of fresh flat-leaf parsley; and 1/4 teaspoon celery salt. Blend until smooth. make about 1 cup (8 oz./250 g).


14. Cucumber tzatziti
In a bowl, mix tiogether 1 container (7 oz./220 g) plain yogurt; 1 cup (5 oz./155 g) peeled abd grated or finely diced English cucumber; 1 teaspoon minced fresh mint or flat-leaf parsley; and a squeeze of lemon juice. Season to taste with salt. makes about 2 cups (16 oz./ 500 g).

15. Chunky tomato salsa
In a bowl, mix together 1 can (14 oz./ 440 g) diced tomatoes with their juice (or 2 large, ripe tomatoes chopped); 1/4 cup (2 oz./60 g) chopped onion; ` cloved garlic, minced; and a handful of chopped fresh cilantro, if you like. season to taste with lime juice, salt and pepper. Add minced jalapeno chile, if you like. make about 2 cups (16 oz./ 500 g).

_______________________________________________________________________

16.Vanilla-raspberry side
Fill a small airtight container about halfway with vanilla yogurt. Top with a thin, smooth layer of raspberry jam. Add another layer of yogurt. top the yogurt with spiral or smiley face of jam, if you like. Closed tightly and refrigerate until ready to go. Pack sliced or skewered fruit dippers (see below) along with the dip. Make 1 serving

Fruit dippers
* fresh apple slices or dried apple chips
* Dried apricot
* Dried banana chips
* Fresh berries or grapes skewered onto toothpicks
* Dried mango strips
* Cantaloupe or honeydew melon slices
* Fresh peach or nectarine slices
* Fresh pineapple wedges
* Halved strawberries

17. Honey granola dip
Fill a small airtight container about halfway with plain or vanilla yogurt. Add a layer of granola and then another layer of yogurt. Top with a generous drizzle of honey and a sprinkling of granola. Closed tightly and refrigerate until ready to go. Pack sliced or skewered fruit dippers (see below) along with the dip. Make 1 serving.

Fruit dippers
* fresh apple slices or dried apple chips
* Dried apricot
* Dried banana chips
* Fresh berries or grapes skewered onto toothpicks
* Dried mango strips
* Cantaloupe or honeydew melon slices
* Fresh peach or nectarine slices
* Fresh pineapple wedges
* Halved strawberries
-------------------------------------------------------------------------------------------------

Mac & cheese, all dress up
All natural macaroni and cheese  1 package (6 oz./ 185 g)
Cheddar, monterey jack, or havarti cheese 1/2 cup (2 oz./60 g) shredded
Parmesan cheese 2 tablespoons, grated
Frozen vegetables such as peas, carrots, shelled edamame, and/or broccoli florets 1 cup (5 oz, 155 g).

Prepare the macaroni and cheese sauce according to the package directions. Stir in the extra cheeses and the vegetables. Cook gently over low heat until the cheese is melt and the vegetable are heated through, about 5 minutes.
Spoon servings into insulated containers as needed and closed tightly to keep warm. Don't forget to pack a fork! ( Let any remaining pasta cool, then cover tightly and refrigerate for up to 5 days).

18. Chicken florentine
In a frying pan, heat 1 teaspoon olive oil over medium heat. Add 1 cup (2 oz/60 g) chopped spinach and 1 cup (6oz/ 185 g) cooked chicken, shredded chicken and stir until the soinach is wikted, 2 - 3 minutes. Stir into the prepare mac. and cheese.

19. Bacon and onion
Just before serving. sprinkle the prepared mac and cheese with 2 - 3 sliced cooked bacon, crumbled, and 2 green onions, chopped.

20. Tex mex
Add 1/2 cup (2 oz/60 g) shredded pepper jack cheese, 1/4 cup (1 and 1/2 oz/45 b) chopped bell pepper, and 1/4 cup (1 and 1/2 oz/45 b) diced canned tomatoes to the prepared mac and cheese and stir until the vegetables are heat through, about 5 minutes.

21. Ham and cheese
Add 2 oz. (60 g) diced ham and 1/2 teaspoon grainy mustard to the prepared mac and cheese. Stir until combine and the ham is heat through, about 5 minutes.

______________________________________________________________

Home made dippers
22. Tortilla chips
Preheat the broiler. Brush both sides of 4 corn tortillas with olive oil. Cut each tortilla into 8 triangles, or cut shapes using cookie cutter. Spread the triangles in a single layer om baking sheet and sprinkle with salt. Toast, turning once, until golden and crisp, 3 -5 minutes. Let cool.

23. Pita chip
Preheat the broiler. Split 2 6 inch (15 cm) pita breads in half to create 4 thin rounds. Brush both sides of rounds with olive oil. Cut each round into 8 triangles. Spread the triangles in a single layer on baking sheet and sprinkle with salt. Toast, turning once, until golden and crisp, 3 minutes. Let cool.

24. Root veggie dip
Preheat the oven to 500 degree F (260 degree C) lightly grease a baking sheet with olive oil. Peel and thinly slice 2 or 3 beets or carrots ( or 1 of each). Arrange the slices in single layer on the prepared sheet. Drizzle with olive oil and sprinkle with salt. Bake, turning once, until crisp, about 20 minutes. Transfer to paper towels to drain.

25. Sweet potato chips
Preheat the oven to 500 degree F (260 degree C) lightly grease a baking sheet with olive oil. Peel 2 sweet potatoes. Halve each length wise. then thinly slice crosswise. Arrange the slices in single layer on the prepared sheet. Drizzle with olive oil and sprinkle with salt. Bake, turning once, until crisp, about 20 minutes. Transfer to paper towels to drain.

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The $5 takeout cookbook (Good, cheap food for when you want to eat in) by Rhonda Lauret Parkinson, Margaret Kaeter, Belinda Hulin, and Jennifer Malott Kotylo, published by Adam media, Avon, Massachusetts


26. Tostadas
Make 4 -10 depending on the tortilla size
Total cost: $.81
1/4 cup of vegetable oil
6 - 8 corn tortilla
1/4 teaspoon salt
1. Spread the oil evenly over the bottom of a large pan. preheat to medium-high temperature.
2. Place tortillas in the hot oil., 1 at a time, and fry ubtil crisp. Flip the tortillas when one side is brown to ensure even cooking.
3. Sprinkle with salt while cooking.
4. Place on paper towel to drain.

27. Chorizo (Mexican sausage)

total cost; 44.11

1 pound ground pork
1/2 tablespoon paprika
1/2 teaspoon ground black pepper
1/2 teas[poon dried oregano
1/2 teaspoon ground cumin
1/8 teaspoon ground coriander
1/3 cup vinegar
1/2 teaspoon garlic powder
1 tablespoon salt
1 tablespoon cayenne paper
1. Place all the ingredients in a large mixing bowl. Mix with your hand until all ingredients are well blended
2. Place in an airtight container. refrigerate for at least 2 days.
3. Form into patties for frying.

28. Lonches
Serves 3. Total cost: $2.41

3 slice bacon
3 large hard rolls
1/4 pound Monterey jack cheese
3/4 cup red chili sauce
Substitute meats and cheeses. Add onion or olive slices.

1. Preheat oven to 350 degree F.
2. Fry the bacon until crisp. Drain off the grease.
3. Thinly slice the cheese. Split the rolls in half hortzontally. Fill generously with cheese and top with bacon strip. Close the rolls o form sandwiches and place on a baking sheet.
4. Put in the oven for 5 to 10 minutes or until the rolls are hot and cheese is melted.
5. While the rolls are baking, heat the sauce to bubbing.
6. Place each filled roll inn a soup bowl and ladle 1/4 cup sauce over the top.


29. Mexican Chicken Casserole
Serves 3. Total cost: $4.13

2 boneless, skinless chicken breast
1/2 small oion
6 flour tortillas
3/4 cup grated Cheddar cheese
5 1/2 ounces cream of mushroom condensed soup
5 1/2 ounces cream of chicken condensed soup
1/2 cup sour cream.
1/4 cup canned chopped jalapeno pepper, drained (or 4 fresh jalapenos)
1/2 cup tomato salsa

Serve over a bed of lettuce with fresh Tostadas(see 27)
1. Preheat oven to 350 degree F
2. Cut the chicken into 1 inch-cube. Peel the onion and grate using the fine side of a vegetable grater. Tear tortillas in to eight.
3. Combine onion, cheese, soups, sour cream and jalapenos in a medium-sized bowl. Make layers in a casserole dish using 1/3 ofb the floue tortallas, soup mixture, chicken, then salsa. Preheat twice, in that order.
4. Cover and bake for 2 hours.

30. Chicken Chalupas
Serves 3. Total cost: $3.64

6 corn tortillas
1/2 cup chicken stock
1/2 pound Monterey jack cheese
1/2 cup sour cream
1 cup spicy chicken(Chapter 2)
1/2 teaspoon paprika

Serve with fresh spinach and fruit compote(see below)
1. Soak the tortillas in 1/4 cup of the stock. Grated the cheese.
2. Combine the remaining chicken stock with sour cream.
3. Layer the ingredients in a casseroles as follow: single layer of soaked tortillas, spicy chicken. sour cream mixture, cheese. Preheat until all ingredients are used. sprinkle with paprika.
3. COVER AND REFRIGERATE AT LEAST 8 HOURS.
4. Preheat oven to 350 degree F. when the oven is heated, bake the dish, uncovered, for 1 hour.

31. Fruit compote

Serves 4. total cost: $1.51
3/4 cup seedless green grapes
3/4 cup fresh strawberries
1 medium orange
2 medium kiwis
1 medium peach
2 1/2 tablespoons confectioners' sugar
1 1.2 tablespoons Triple Sec or Cointreau liqueur
1 1/2 tablespoon tequila
3/4 tablespoon lime juice

1. Cut the grape in half. Remove the stems from the strawberries and cut the fruit in half. Peel the orange and slice into 1/4- inch rounds. Peel the kiwis and slice into 1/4 inch rounds. Peel the peaches, remove pits and cut into 1/4 thick slices.
in a small jar, combine sugar, liqueur, tequila, and lime juice. Cover and shake until well mixed. Combine all fruit in a large serving bowl and toss to mix. Add the dressing and toos the fruit until well covered. Cover and refrigerate for at least 4 hours before serving.

32. Spicy chicken
Yields 2 cups. total cost: $3.84


1/2 garlic clove
1 medium tomatoes
3/4 fresh jalapeno chili peppers
1/4 bunch fresh cilantro
1/4 bay leaf
1/2 teaspoon salt
1/2 teaspoon ground black pepper
2 ounces Italian salad dressing
1/4 fry chicken (about 1 1/2 pound)

1. peel and minced garlic. Cut the tomatoes into 1 inch pieces, reserving the juice. Remove the stem and seeds from the chili peppers. Remove the stems from the cilantro.
2. Combine all ingredients in a heavy pot. Cover and cook over medium heat for about 5 hours.
3. remove the meat from the broth and let cool. Remove and discard the skin and bone, and shred the meat with forks or in a food processor. Discard the broth.
























Most common diseases of 50 plus - Diseases of Central Nervous system(CNS): Dementia - The Preventive Common Free Radical Scavengers

By Kyle J. Norton Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

         Diseases of Central Nervous system

                           Dementia



About 5-8% of all people over the age of 65 have some form of dementia, and this number doubles every five years above that age. Dementia is the loss of mental ability, severe enough to interfere with people's every life and Alzheimer's disease is the most common type of dementia in aging people.
V.  Preventions
B. Antioxidants and Dementia 
B.3. Common Free Radical Scavengers 
1. Bilirubin
Bilirubin is a prosthetic group with a unique function in breaking down molecules into smaller units for releasing energy, excreted in bile and urine(263). As a cellular antioxidant, it may protect against diseases associated with oxidative stress, through mildly elevated serum bilirubin levels and activation of heme oxygenase(264) and revert to biliverdin, a green tetrapyrrolic bile pigment, through antioxidant redox cycle in inhibition of the effects of mutagens when oxidized(265). A significant reduction of levels of bilirubin, has shown to associate to patients with Alzheimer's disease (AD)(266).

2. Carotenoids
Carotenoids are organic pigments, occurring in the chloroplasts and chromoplasts of plants and some other photosynthetic organisms like algae, some bacteria. The antioxidant has been under intense scrutiny studies for finding of their potential in modulated chronic disease risk and prevention of vitamin A deficiency(267). Plasma levels of HDL and carotenoids have shown to lower in patients with dementia related vascular disorders(268) and Alzheimer's disease(AD)(269).

Beta-Carotene, an organic compound is classified as a terpenoid, a strongly-coloured red-orange pigment in plants and fruits.
 Beta-Carotene is not toxic and stored in liver for the production of vitamin A(270) shown to inhibit cancer cell in experiment(271)(272). Its anti oxidative effects has shown to cover the main pathways for formation, transformation, and decay of free radicals(273), through  relation to the antioxidant/pro-oxidant properties(274). According to Yale University, the decreased non-enzymatic antioxidants in blood, including β-carotene showed a significant oxidative damage in the process of neurodegeneration(275).

3. Flavonoids
Flavonoid also known as Vitamin P and citrinare, is a yellow pigments having a structure similar to that of flavones occurred in varies plants. The antioxidant has been in human history for over thousands of years and discovered by A. S. Szent-Gyorgi in 1930. Vitamin C and flavonoids combination has shown to expressed wound healing in animal model(276).

Flavonoids process a property as antioxidants in inhibition of  cell growth, differentiation and development, and overexpressed in gastric cancer, colorectal cancer, pancreatic cancer, etc., probably through cell cycle arrest and induced apoptosis(277). Intake of antioxidant flavonoids is associated  to the reduced  risk of incident dementia(278)and mild cognitive impairment(279).

Although nitric oxide is considered a free radical produced by immune system to destroy microbial(281) and cancerous cells(282)(283). Over produced NO, showed to  induce inflammation(280), flavonoids inhibit NO production of peroxynitrite(284) which is found to induce mitochondrial dysfunction associated with PD progression(285) for prevention of the cause of inappropriate damage to blood and tissues(284).

4. Vitamin A, C, E
a. Vitamin A
Vitamin A occurred in the form retinol is best known for its function in maintaining a critical role in vertebrate development, cell differentiation, reproduction, vision and immune system(286). The vitamin also acts as an the major peroxyl radical scavenger role in biological lipid phases such as membranes or low-density lipoproteins (LDL)(291)(288), including incidence of bronchopulmonary dysplasia (BPD) with respiratory failure(290). Prevention of its depletion in fighting the increased free radicals activity by radiation(287), and enhancement of the productions of insulin pancreas(289).

b. Vitamin C
Vitamin C beside, presences in aqueous compartments (e.g. cytosol, plasma, and other body fluids)(292) plays an important role  in synthesis of collagen, carnitine, catecholamine and the neurotransmitter norepinephrine(293). As an water soluble vitamin, vitamin C can be easily carry in blood, operate in much of the part of body. By recycling vitamin E, vitamin C also helps to fight against forming of free radicals(294). By enhancing the immune system(295)(296), it promotes against the microbial and viral(298) and irregular cell growth causes of infection and inflammation(297).
Vitamin C also is a free radical scavenger in inhibiting pollution cause of oxidation(299).

c. Vitamin E
Vitamin E is used to refer to a group of fat-soluble compounds, including  both tocopherols and tocotrienols(300) discovered by researchers Herbert Evans and Katherine Bishop. The viutamin beside is important in protecting muscle weakness(300), repairing damage tissues(302) caused by oxidation(303), and promoting blood clotting in healing wound(302), etc. It also is one of powerful antioxidant, moved into the fatty medium to prevent lipid peroxidation(301), inhibited free radicals chain reactions by curtailing them before they can start(304) and prevented or delayed cognitive decline  tested in clinical trials in both ageing population of and mild cognitive impairment in patients with Alzheimer's disease (AD)(306), according to R & D Human Nutrition and Health(305).

5. Etc.

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Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

For over 100 healthy recipes, http://diseases-researches.blogspot.ca/p/blog-page_17.html


References(263) http://www.ncbi.nlm.nih.gov/pubmed/24151358
(264) http://www.ncbi.nlm.nih.gov/pubmed/19754364
(265) http://www.ncbi.nlm.nih.gov/pubmed/22438843
(266) http://www.ncbi.nlm.nih.gov/pubmed/16534775
(267) http://www.ncbi.nlm.nih.gov/pubmed/8621054
(268) http://www.ncbi.nlm.nih.gov/pubmed/24448787
(269) http://www.ncbi.nlm.nih.gov/pubmed/24582848
(270) http://www.ncbi.nlm.nih.gov/pubmed/17665093
(271) http://www.ncbi.nlm.nih.gov/pubmed/8127329
(272) http://www.ncbi.nlm.nih.gov/pubmed/7959271
(273) http://www.ncbi.nlm.nih.gov/pubmed/8529916
(274) http://www.ncbi.nlm.nih.gov/pubmed/12630889
(275) http://www.ncbi.nlm.nih.gov/pubmed/23867235
(276) http://www.ncbi.nlm.nih.gov/pubmed/16633732
(277) http://www.ncbi.nlm.nih.gov/pubmed/24707875
(278) http://www.ncbi.nlm.nih.gov/pubmed/10959944
(279) http://www.ncbi.nlm.nih.gov/pubmed/25515512
(280) http://www.ncbi.nlm.nih.gov/pubmed/11515807
(281) http://www.ncbi.nlm.nih.gov/pubmed/15189992
(282) http://www.ncbi.nlm.nih.gov/pubmed/25519577
(283) http://www.ncbi.nlm.nih.gov/pubmed/12528889
(284) http://www.ncbi.nlm.nih.gov/pubmed/10660664
(285) http://www.ncbi.nlm.nih.gov/pubmed/17936517
(286) http://www.ncbi.nlm.nih.gov/pubmed/24662164
(287) http://www.ncbi.nlm.nih.gov/pubmed/24583267
(288) http://www.ncbi.nlm.nih.gov/pubmed/10926898
(289) http://www.ncbi.nlm.nih.gov/pubmed/25451926
(290) http://www.ncbi.nlm.nih.gov/pubmed/24388327
(291) http://www.ncbi.nlm.nih.gov/pubmed/1444060
(292) http://www.ncbi.nlm.nih.gov/pubmed/1444060
(293) http://www.ncbi.nlm.nih.gov/pubmed/23177992
(294) http://www.ncbi.nlm.nih.gov/pubmed/12841645
(295) http://www.ncbi.nlm.nih.gov/pubmed/6604680
(296) http://www.ncbi.nlm.nih.gov/pubmed/20515554
(297) http://www.ncbi.nlm.nih.gov/pubmed/24766384
(298) http://www.ncbi.nlm.nih.gov/pubmed/23988864
(299) http://www.ncbi.nlm.nih.gov/pubmed/13701588
(300) http://www.ncbi.nlm.nih.gov/pubmed/10385606
(301) http://www.ncbi.nlm.nih.gov/pubmed/11579997
(302) http://www.ncbi.nlm.nih.gov/pubmed/24524083
(303) http://www.ncbi.nlm.nih.gov/pubmed/1897277
(304) http://www.ncbi.nlm.nih.gov/pubmed/15593395
(305) http://www.ncbi.nlm.nih.gov/pubmed/25460513
 

Monday, January 26, 2015

Most common diseases of 50 plus - Diseases of Central Nervous system(CNS): The Preventive Metals Binding Proteins

By Kyle J. Norton Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

         Diseases of Central Nervous system

                           Dementia



About 5-8% of all people over the age of 65 have some form of dementia, and this number doubles every five years above that age. Dementia is the loss of mental ability, severe enough to interfere with people's every life and Alzheimer's disease is the most common type of dementia in aging people.
V.  Preventions
B. Antioxidants and Dementia 
B.2. Metals binding proteins 
1. Ceruloplasmin
Ceruloplasmin, the major copper-carrying protein in the blood plays a role in iron metabolism(227). Decreased level of ceruloplasmin impaired ferroportin stability(229)(230)may induce progressive action tremor, and cognitive decline(227), causing the forming of  superoxide anion radicals(231) and iron overload in the brain, liver, pancreas, and other organs(232).

2. Ferritin
Ferritin, the protein produced by almost all living organisms, acts as a component to fight against iron deficiency and iron overload(233)(234). In a soluble and non-toxic form, the protein is transported to the body needs, including organs(236) for enhancement of the immune system in the presence of an infection(237),  proliferation of lymphoid and myeloid cells(235), cancer(238) and prevention of the infectious agent in attempt of binding iron to form free radicals(239) in most cellular oxidation reactions(239).

3. Lactoferrin
Lactoferrin, a multifunctional protein of the transferrin family, is one of the components of the immune system(240) of the body by fighting against foreign invasion of bacteria and virus(241)(242) and lipid oxidation(243) by inhibiting oxidation in a concentration-dependent manner even at concentrations beyond its capacity(244).

4. Metallothionein
Metallothionein, a family of cysteine-rich(24), low molecular weight proteins binds both physiological heavy metals(245) through detoxified fraction of accumulation(245). It also captures harmful superoxide and hydroxyl radicals(246) by binding the metal ions(247)(248) bounded to cysteine(249).

5. Transferrin
Transferrin, a glycoprotein binded iron very tightly but reversibly, enhances the immune system in fighting against infection, inflammation(250) by creating an environment low in free iron(251) that impedes cell oxidation(253)(254), through rapidly evolving sites reverse to bacterial binding in counteract bacterial iron piracy(250). Transferrin deformation and aggregation are found to associate to neurological disorders such as Parkinson's and Alzheimer's disease(252).

6. Hemoglobin
Hemoglobin, the protein molecule in red blood cells enhances the carrying of oxygen from the lungs to the body's tissues and return CO2 from the tissues to the lungs(255)(256). During oxidate stress, the cell membrane is protected by intraerythrocytic hemoglobin from the forming of free radicals(259), probably through regulating NO(258) and auxin homeostasis(257).

7. Myoglobin
Myoglobin is an iron- and oxygen-binding protein found in the muscle tissue of vertebrates. The binding of oxygen by myoglobin(260) through interaction with pathogens establishment of successful infection and survival  is probably through peroxidase activity(261), thus reducing the free radicals damage caused by oxidate stress(261)(262).

8. Etc.

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Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

For over 100 healthy recipes, http://diseases-researches.blogspot.ca/p/blog-page_17.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca    

References
(227) http://www.ncbi.nlm.nih.gov/pubmed/10930377
(228) http://www.ncbi.nlm.nih.gov/pubmed/19769463
(229) http://www.ncbi.nlm.nih.gov/pubmed/22634395
(230) http://www.ncbi.nlm.nih.gov/pubmed/16673405
(231) http://www.ncbi.nlm.nih.gov/pubmed/24090962
(232) http://www.ncbi.nlm.nih.gov/pubmed/25280422
(233) http://www.ncbi.nlm.nih.gov/pubmed/24814729
(224) http://www.ncbi.nlm.nih.gov/pubmed/25501153
(225) http://www.ncbi.nlm.nih.gov/pubmed/25511255 
(226) http://www.ncbi.nlm.nih.gov/pubmed/25052430
(227) http://www.ncbi.nlm.nih.gov/pubmed/25498860
(228) http://www.ncbi.nlm.nih.gov/pubmed/25464026
(229) http://www.ncbi.nlm.nih.gov/pubmed/20655381
(230) http://www.ncbi.nlm.nih.gov/pubmed/24921009
(231) http://www.ncbi.nlm.nih.gov/pubmed/6284006
(232) http://www.ncbi.nlm.nih.gov/pubmed/25089372
(233) http://www.ncbi.nlm.nih.gov/pubmed/4014070
(234) http://www.ncbi.nlm.nih.gov/pubmed/6830706
(235) http://www.ncbi.nlm.nih.gov/pubmed/18191543
(236) http://www.ncbi.nlm.nih.gov/pubmed/17459943 
(237) http://www.ncbi.nlm.nih.gov/pubmed/19428486
(238) http://www.ncbi.nlm.nih.gov/pubmed/23891969
(239) http://www.ncbi.nlm.nih.gov/pubmed/22155779
(240) http://www.ncbi.nlm.nih.gov/pubmed/21847071
(241) http://www.ncbi.nlm.nih.gov/pubmed/25282173
(242) http://www.ncbi.nlm.nih.gov/pubmed/15222464
(243) http://www.ncbi.nlm.nih.gov/pubmed/22304665
(244) http://www.ncbi.nlm.nih.gov/pubmed/11052766
(245) http://www.ncbi.nlm.nih.gov/pubmed/25528420
(246) http://www.ncbi.nlm.nih.gov/pubmed/18561335
(247) http://www.ncbi.nlm.nih.gov/pubmed/16872588
(248) http://www.ncbi.nlm.nih.gov/pubmed/1342190
(249) http://www.ncbi.nlm.nih.gov/pubmed/24493013
(250) http://www.ncbi.nlm.nih.gov/pubmed/25504720
(251) http://www.ncbi.nlm.nih.gov/pubmed/12476940
(252) http://www.ncbi.nlm.nih.gov/pubmed/22119572
(253) http://www.ncbi.nlm.nih.gov/pubmed/7298642
(254) http://www.ncbi.nlm.nih.gov/pubmed/7925932
(255) http://www.ncbi.nlm.nih.gov/pubmed/23820271
(256) http://www.ncbi.nlm.nih.gov/pubmed/12683610
(257) http://www.ncbi.nlm.nih.gov/pubmed/24905914
(258) http://www.ncbi.nlm.nih.gov/pubmed/24815022
(259) http://www.ncbi.nlm.nih.gov/pubmed/20003712
(260) http://www.ncbi.nlm.nih.gov/pubmed/15756816
(260) http://www.ncbi.nlm.nih.gov/pubmed/1575681
(261) http://www.ncbi.nlm.nih.gov/pubmed/24885788
(262) http://www.ncbi.nlm.nih.gov/pubmed/24885788

Sunday, January 25, 2015

Most common diseases of 50 plus - Diseases of Central Nervous system(CNS): The Preventive Antioxidant enzymes

By Kyle J. Norton Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

         Diseases of Central Nervous system

                           Dementia



About 5-8% of all people over the age of 65 have some form of dementia, and this number doubles every five years above that age. Dementia is the loss of mental ability, severe enough to interfere with people's every life and Alzheimer's disease is the most common type of dementia in aging people.
V.  Preventions
B. Antioxidants and Dementia
B.1. Antioxidant enzymes
Antioxidant enzymes, chemical substances found in plants, protect the body from damage of free radicals by terminating the chain reactions through removing free radical intermediates and inhibiting  oxidation reactions.
1. Catalase
Catalase is an enzyme, found in most living organisms exposed to oxygen for action of converse hydrogen peroxide (free radicals)(226) to water and oxygen as a rate of 40 million molecules of hydrogen peroxide to water and oxygen each second, using either an iron or manganese cofactor. The antioxidants showed to protect cells against the toxic effects of hydrogen peroxide in pathogenesis of oxidative stress-related diseases(222) inducted early stages of aggregation of the amyloid peptides(225), including neurodegeneration(224) such as Alzheimer's diseas(223).

2. Glutathione peroxidase
The function of glutathione peroxidase is to protect the organism from oxidative damage and induced neurodegenerative diseases, such as Alzheimer's disease(228) by removing lipid hydroperoxides(227), causes of oxidation of lipid cell membranes. probably through its major cellular peroxide scavenging enzyme(228) and maintaining the oxidative phosphorylation system and protecting mitochondria(229) and protecting oxidative injury and amyloid toxicity of cortical neurons(230).

3. Glutathione reductase
Glutathione reductase, an antioxidant enzyme capable to regenerate Gglutathione (GSH) levels at 24h(233),  and reduced pair of sulfur atoms glutathione to a organosulfur compound form of antioxidant (consisting of three amino acids joined by peptide bonds) may play an important role in prevention of damage of important cellular components induced neurodegenerative diseases such as PD(231)(232), caused by free radicals and peroxides. probably through its antioxidant and anti-inflammatory properties(231)

4. Super oxide dismutase (both Cu-Zn and Mn)
Super oxide dismutase is an important antioxidant and immune defense(224) in nearly all cells exposed to oxygen by converting superoxide into oxygen and hydrogen peroxide depending on the metal cofactor such as both Cu-Zn and Mn(225), probably through the attenuation of superoxide dismutases (SODs) and catalases (CATs)(225) in enhanced and protection of biochemical/molecular/neurobiological  function(226).

Dementia Memory Loss ReversalGuarantee to Stop Progression and Reverse Memory Loss in Alzheimer and  Dementia  with step by step instructions through Scientific Studies  within 2 Months or your Money back

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

For over 100 healthy recipes, http://diseases-researches.blogspot.ca/p/blog-page_17.html
 
References
(222) http://www.ncbi.nlm.nih.gov/pubmed/25152049
(223) http://www.ncbi.nlm.nih.gov/pubmed/24524075
(224) http://www.ncbi.nlm.nih.gov/pubmed/25241122(225) http://www.ncbi.nlm.nih.gov/pubmed/16141213
(226) http://www.ncbi.nlm.nih.gov/pubmed/24887508
(227) http://www.ncbi.nlm.nih.gov/pubmed/10930377
(228) http://www.ncbi.nlm.nih.gov/pubmed/19769463
(229) http://www.ncbi.nlm.nih.gov/pubmed/22634395
(230) http://www.ncbi.nlm.nih.gov/pubmed/16673405
(231) http://www.ncbi.nlm.nih.gov/pubmed/24090962

Saturday, January 24, 2015

Most common diseases of 50 plus - Diseases of Central Nervous system - The Preventive Do's and Do Not's list

By Kyle J. Norton Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

         Diseases of Central Nervous system

                           Dementia



About 5-8% of all people over the age of 65 have some form of dementia, and this number doubles every five years above that age. Dementia is the loss of mental ability, severe enough to interfere with people's every life and Alzheimer's disease is the most common type of dementia in aging people.

V.  Preventions
A. Do's and Do Not's list
 1. Mediterranean diet
If you are typical American dieter, you are at increased risk for the development of dementia when you get older as the diet is classified as one of the most unhealthy diet in the existence, according to studies. Mediterranean diet, high monounsaturated fatty acids energy intake appeared to be associated with a high protection against cognitive decline and reduced the prevalence of AD in older people(208). Also recent research supports the hypothesis of calorie intake, among other non-genetic factors, in influence of the risk of clinical dementia.(209).

2. Yoga  
Senile dementia is the mental deterioration, i.e, loss of intellectual ability associated with old age. Yoga is believed to have beneficial effects on cognition, probaby through attenuation of emotional intensity and stress reduction. Yoga participation showed to improve the memory performance, and all other psychophysiological parameters, in patient with dementia(3), including intellect, attention, thinking, comprehension and personality, with preservation of normal level of consciousness(210), according to G.J. Patel Ayurved College.

3. Aging of theory of mind
According to Aging of theory of mind, educational level and cognitive processing are two factors influencing the pattern of the aging.Younger and older group with equally high education outperformed the older group with less education in false-belief and faux-pas tasks, with younger group outperformed the other two groups in the cognitive processing tasks, according to Anhui Medical University(211)

3. Moderate alcohol drinking
Moderate alcohol drinking of less than 2 cups for men and 1 cups for women are said to offers possible health benefits(3), but Binge drinking (ie, alcohol exceeding the amount of 5 bottles of beer or a bottle of wine on 1 occasion at least monthly) in midlife is associated with an increased risk of dementia, according to the follow-up, 103 participants had developed dementia(212).

4.  Stop Smoking or never smoke before
Smoking is a risk factor for several life-threatening diseases, but its long-term association with dementia is controversial and somewhat understudied.  According to a total of 5367 people (25.4%), heavy smoking in midlife was associated with a greater than 100% increase in risk of dementia, AD, and VaD more than 2 decades later(213).

5. Drink you tea and coffee
Caffeine in tea and coffee may enhance cognitive function acutely, but its link to dementia is somewhat inconsistent, but most studies support coffee's favorable and protective effects against cognitive decline, dementia or AD. Coffee drinking of 3-5 cups per day at midlife was associated with a decreased risk of dementia/AD by about 65% at late-life(214).

6. Eat you fruits and veggies 
Fruits and veggies containing high amounts of antioxidant enhance the immune system in fighting against forming of free radicals cause to damage to the brain cells of that can lead to dementia. Vitamin E and vitamin C supplements in combination were associated with reduced prevalence and incidence of AD, according to The Johns Hopkins University(215).

7. Regular and moderate exercise for elder
 Regular and moderate exercise may attenuate  the cognitive dysfunctioning, but theirs' induced changes in cognition were not correlated with changes in mood/anxiety, probably through some separate neural systems mediation(216).

8.  Avoid nutritional deficiency with balance diet
a. Beyond our believe, an excess of dietary carbohydrates, particularly fructose, alongside a relative deficiency in dietary fats and cholesterol, may lead to the development of Alzheimer's disease(217).
b. For more of Avoid nutritional deficiency with balance diet, please visit(218)

9. Avoid environment risk of dementia
Certain environment toxins produced as a result of industrialization or naturally have been linked to cognitive degenerative diseases. According to University of British Columbia, novel environmental toxins: steryl glycosides, a potential etiological factor for age-related neurodegenerative diseases, showed   signs of mimicked ALS-PDC, including progressive deficits in motor, cognitive, and olfactory functions associated with neuron loss in the spinal cord, nigrostriatal system, cortex, hippocampus, and olfactory bulb in fed mice(219).

10. No illicit drug, please(220)
Illicit drug used may cause nervous system impairment as a result of direct and indirect effects on the integrity and function of nervous system tissue and, potentially, through immune effects, especially, up to 40% risk of nervous system impairment for patients with  HIV-1 infection.

11. Prevent prolonged period of using certain drug
As aging, accumulation of toxins of certain medication used to treat certain diseases, such as antidepressants, sedatives, cardiovascular drugs and anti-anxiety medications may cause increased risk of cognitive dysfunction causes of dementia-like symptoms(221).

12. Etc.
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References
(209) http://www.ncbi.nlm.nih.gov/pubmed/18466323
(210) http://www.ncbi.nlm.nih.gov/pubmed/22342535
(211) http://www.ncbi.nlm.nih.gov/pubmed/22408297
(212) http://www.ncbi.nlm.nih.gov/pubmed/22515730
(213) http://www.ncbi.nlm.nih.gov/pubmed/16222166
(214) http://www.ncbi.nlm.nih.gov/pubmed/20182054
(215) http://www.ncbi.nlm.nih.gov/pubmed/14732624
(216) http://www.ncbi.nlm.nih.gov/pubmed/22554780
(217) http://www.ncbi.nlm.nih.gov/pubmed/21402242
(218) http://healthyliving50over.blogspot.ca/2012/04/delay-dementia-causes-of-dementia.html
(219) http://healthyliving50over.blogspot.ca/2012/05/environment-toxin-causes-of-dementia.html
(220) http://healthyliving50over.blogspot.ca/2012/05/substance-abuse-causes-of-dementia.html
(221) http://healthyliving50over.blogspot.ca/2012/05/medication-causes-of-dementia.html

Friday, January 23, 2015

Most common diseases of 50 plus - Diseases of Central Nervous system - The Complications of Dementia

By Kyle J. Norton Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

         Diseases of Central Nervous system

                           Dementia



About 5-8% of all people over the age of 65 have some form of dementia, and this number doubles every five years above that age. Dementia is the loss of mental ability, severe enough to interfere with people's every life and Alzheimer's disease is the most common type of dementia in aging people.

V. The Symptoms and Complications
B. The Complications
 According to physical complications of patients with dementia occurred in ward in the 12 months from April 2007 to March 2008 recorded in Ichinomiya City Hospital, Ichinomiya, the physical complications can be divided into two categories: (i) serious emergencies occurring in the ward with a possible high risk of mortality within a few days (e.g. pneumonia and upper airway obstruction); and (ii) life-threatening complications arising in the ward that required diagnosis and treatment by specialists from other medical departments (e.g. bone fracture and cancer)(202).
1. Pneumonia
 Pneumonia is common among patients with advanced dementia, especially toward the end of life, due to microbial  inffection, according to Beth Israel Deaconess Medical Center(203).

2. Obstructive Sleep Apnea Syndrome (OSAS) 
The prevalence of OSAS increased with aging, occurring in up to 25% of older adults and up to 48% in patients with Alzheimer's disease, showed to induce symptoms of hypoxia, fragmented sleep, daytime sleepiness, cognitive dysfunction, functional decline, and brain damage, due to reduced cerebral blood flow, ischemic brain lesions, microvascular reactivity, white matter lesions, and grey matter loss(204)

3. Bone fracture
Bone mass and dementia in elderly hip fracture patients may be associated to levels of different aluminium concentrations in water supplies in the areas affecting the negative calcium balance of age-related osteoporosis together predispose to senile dementia.(205)

4. Urinary incontinence
 Urinary incontinence is a common problem in dementia. Almost invariably, the person with dementia will develop incontinence as the disease progresses. However, the primary reasons for incontinence are often not because of any significant pathology in the urinary system. Rather, it is due to factors outside the urinary system, including insertion of tube in assisting urinary flow(206)

5. Venous thromboembolism
 Venous thromboembolism (VTE), caused by a blood clot breaking loose and traveling in the blood, in patients with dementia had a high incidence of fatal pulmonary embolism (PE) and fatal bleeding, according to the study of 37988 patients with 1316 (3.5%) having dementia(207).

6. Etc. 
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References
(202) http://www.ncbi.nlm.nih.gov/pubmed/20377817
(203) http://www.ncbi.nlm.nih.gov/pubmed/20625013
(204) http://www.ncbi.nlm.nih.gov/pubmed/20739254
(205) http://www.ncbi.nlm.nih.gov/pubmed/3239502
(206) http://www.ncbi.nlm.nih.gov/pubmed/16642241
(207) http://www.ncbi.nlm.nih.gov/pubmed/22374336

Thursday, January 22, 2015

Most common diseases of 50 plus - Diseases of Central Nervous system - The Symptoms and Complications of Dementia

By Kyle J. Norton Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

         Diseases of Central Nervous system

                           Dementia



About 5-8% of all people over the age of 65 have some form of dementia, and this number doubles every five years above that age. Dementia is the loss of mental ability, severe enough to interfere with people's every life and Alzheimer's disease is the most common type of dementia in aging people.

IV. Symptoms and Complications of Dementia
Dementia is a neuropsychiatric disorder induced of cognitive impairment and behavioral disturbances. The behavioral and psychological symptoms of dementia (BPSD) are common, with a progressive loss of memory and other mental abilities, affecting a person's ability to perform usual tasks in everyday life.
A. Symptoms
A.1. Symptoms of Alzheimer's disease 
Alzheimer's disease is a brain disorder, affecting over 1 million people in US alone with well known  symptoms of lack of concentration (56%), tremors (56%), depression (44%), lack of cooperation (36%), and delusions (32%), psychotic symptoms (delusions, hallucinations, and delirium) and tremors, and emotional symptoms (tearfulness and apathy, lack of concentration and appetite change), according to Hospital de Cruces, Plaza de Cruces s/n, Barakaldo in a study of total of 1014 patients(177) and other symptoms of 

1. Increasing forgetfulness(178)
2. Communication difficulty(179)
3. Anxiety(180)
4. Mood and personal change(181)
5. Delay recall(183)
6. Repeat question(183)
7. Memory loss(182)
8 Aberrant motor behavior (184)
9. Sleep problems (184)
10. Eating problems (184) and
11. Agitation/aggression (184)
10. Etc.

A.2. Symptoms of Diminished quality of acetylcholine
If the nerves located in front of the brain perish, diminished quality of acetylcholine, it can cause language difficulty, memory loss, concentration problem and reduce mobile skills because of lacking reaction in muscular activity and refection.
Symptoms of deficiency of acetylcholine include(185)
1. Difficulty remembering names and faces after meeting people
2. Difficulty remembering peoples birthdays and numbers
3. Difficulty remembering lists, directions or instructions
4. Forgetting common facts
5. Trouble understanding spoken or written language
6. Forget where I put things 
7. Slowed and/or confused thinking
8. Difficulty finding the right words before speaking
9. Disorientation
10. Prefer to do things alone than in groups / social withdrawal
11. Rarely feel passionate
12. Feel despair and lack joy
13. Lost some of my creativity / lack imagination
14 Dry mouth
15. Etc.

A.3. Dementia due to long-term alcohol abuse
Dementia is common in patients with alcoholism. Most symptoms of alcohol dementia are also presented in other types of dementia, with a few qualitative differences(186) involved both cortical and subcortical pathology. According to the article, "What's alcohol-related dementia?" Alcohol dementia induced deterioration in intellectual function with memory not being specifically affected, such as disinhibition, loss of planning, and executive functions and a blithe disregard for the consequences of their behaviour,  affecting mostly of women in  the ages between 30 - 70  with the better rates better than for Korsakoff's Psychosis(187).
Other symptoms in deficits are most frequently observed on tasks of visuospatial function, memory(188) and higher-order (executive) tasks(189)

A.4. Multi-infarct dementia
Also known as vascular dementia, is the second most common form of dementia after Alzheimer's disease in older adults, caused by different mechanisms, affecting the vascular lesions in the brain.with major neurovegetative symptoms of depression unaccompanied by depressed mood/anhedonia in patients with clinically-diagnosed Alzheimer's disease (AD) and multi-infarct dementia (MID)(190).
Symptoms include memory deficits(192) such as
1. Confusion
2. Memory problems
3. Wandering Getting lost
and
4. At least one of behavioural or psychological symptom, such as appetite disturbances irritability and anxiety and emotional suppresion(such as laughing inappropriately, crying inappropriately)
(193), and
5. Difficulty following instructions, and 
6. Bladder incontinence
7. Bowel incontinence(191)

A.5. Dementia associated with Parkinson's disease
Parkinson disease (PD) is a disabling, progressive condition cause of cognitive deficits due to the interruption of frontal-subcortical loops that facilitate cognition and that parallel the motor loop, affecting motor function. These include olfactory deficit, sleep problems such as rapid eye movement behaviour disorder, constipation and male erectile dysfunction.(194).
Other symptoms due to to dopamine (DA) deficiency, include, dysexecutive behaviors(196), such as planning, abstract thinking, flexibility and behavioural control and postural disabilities(197) and
1. Constipation
2. Difficulty swallowing
3. Choking, coughing, or drooling
4. Excessive salivation
5. Excessive sweating
6. Loss of bowel and/or bladder control(195)

A.6. Creutzfeldt-Jakob disease (CJD)
People who have eaten contaminated beef in many years, may be infected with Creutzfeldt-Jakob disease (CJD) without even knowing it. Creutzfeldt-Jakob disease is a quickly progressing and fatal disease,  characterized by rapidly progressive dementia. Initially, individuals experience problems with muscular coordination, personality changes, including impaired memory, judgment, and thinking and impaired vision. People with the disease also may experience insomnia, depression, or unusual sensations.(198).

A.7. Subdural hematoma
 Subdural hemorrhages, the accumulation of blood beneath the outer covering of the brain resulted from the rupture of blood vessel may cause an increase in tracranial pressure, leading compression and damage to delicate brain tissue. Acute subdural hematoma has a high mortality rate.
Other symptoms include
1. Intermittent numbness and weakness of extremity(199) and
2. Loss of consciousnes(201)
3. Irritability
4. Seizures
5. Pain
6. Headache
7. Dizziness
8. Disorientation
9. Weakness
10. Weakness or lethargy
11. Nausea or vomiting
12. Loss of appetite
13. Personality changes
14. Confused speech
15. Difficulty with balance or walking
16. Altered breathing patterns
17. Hearing loss or hearing ringing (tinnitus)
18. Blurred Vision
19. Deviated gaze, or abnormal movement of the eyes(200)
20. Etc.

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Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

For over 100 healthy recipes, http://diseases-researches.blogspot.ca/p/blog-page_17.html

References
(177) http://www.ncbi.nlm.nih.gov/pubmed/20920205
(178) http://www.ncbi.nlm.nih.gov/pubmed/21315756
(179) http://www.ncbi.nlm.nih.gov/pubmed/25356002
(180) http://www.ncbi.nlm.nih.gov/pubmed/16166409
(181) http://www.ncbi.nlm.nih.gov/pubmed/10796526
(182) http://www.ncbi.nlm.nih.gov/pubmed/25481271
(183) http://www.ncbi.nlm.nih.gov/pubmed/22122408
(184) http://www.ncbi.nlm.nih.gov/pubmed/25065098
(185) http://www.ncbi.nlm.nih.gov/pubmed/18849899
(186) http://www.nutritional-healing.com.au/content/articles-content.php?heading=Acetylcholine%20deficiency
(187) http://neurology.health-cares.net/alcohol-related-dementia.php
(188) http://www.ncbi.nlm.nih.gov/pubmed/25119654
(189) http://www.ncbi.nlm.nih.gov/pubmed/23347747
(190) http://www.ncbi.nlm.nih.gov/pubmed/22164676
(191) http://www.rightdiagnosis.com/m/multi_infarct_dementia/symptoms.htm
(192) http://www.ncbi.nlm.nih.gov/pubmed/24685627
(193) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4006603/
(194) http://www.ncbi.nlm.nih.gov/pubmed/20642073
(195) http://www.helpguide.org/elder/parkinsons_disease.htm
(196) http://www.ncbi.nlm.nih.gov/pubmed/25511521
(197) http://www.ncbi.nlm.nih.gov/pubmed/25510818
(198) http://www.ninds.nih.gov/disorders/cjd/detail_cjd.htm#186463058
(199) http://www.ncbi.nlm.nih.gov/pubmed/11558288
(200) http://www.nlm.nih.gov/medlineplus/ency/article/000713.htm