Candida albicans are members of a large group of microorganism whose cells contain complex structures enclosed within the membranes, including yeast(2)(3), fungi(4)(5)(6), and mold(6) that live among the gut flora in the human mouth and gastrointestinal tract.
Non-albicans Candida (NAC) species cause 35-65% of all candidaemias in the general patient population(1).
According to joint study, in many cases, biofilm(microorganisms with cells stick to each other on a surface) formation(7) gene mutations(8) and overexpression of genes(9)(10) are often associated with increased Candida resistance toward antifungal agents.
Foods stimulated an overgrowth of fungus candida
1. Fruits and artificial ingredients
The high sugar content in fruit feeds Candida except for green apples, citrus, berries, and avocado(186)
and artificial ingredients can depress the immune system(187).
2. Aged cheese(188)
Candida famata found in aged cheese may induce invasive candidiasis(188).
3. Additive and preservation
Men made chemicals can disrupt the digestive track friendly bacteria and allow candida overgrowth(189)(190) such as citric acid. Non-organic food like meat or eggs can also contain antibiotics and steroids for faster growth(191).
4. Alcohol(192)
Alcohol can depress the liver(193) and the immune system(194)(195), causing overgrowth candida.
5. Caffeine, sugar, and sweetener
Caffeine(196)(197), sugar and sweetener(198) all harmful to the body and feed candida
6. Gluten
Gluten is a protein composite that appears in foods processed from wheat and related species
that can cause immune suppression(199)(200)(201).
7. Mushrooms
Mushroom which is the fleshy, spore-bearing fruiting body of a fungus, typically produced above ground on soil or on its food source can promote fungus overgrowth(202).
8. Condiments(203)
Condiment which is a sauce or seasoning added to food to impart a particular flavor can depress the immune system(204), causing candida.
9. Vinegar but not apple cider vinegar
Vinegar is an acidic liquid produced from the fermentation of ethanol in a process that yields its key ingredient, an acetic acid which can deplete the stomach of acids and cause inflammation(205)(206) in the digestive tract, including acetic acid ulcer(205).
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Non-albicans Candida spp. causing fungaemia: pathogenicity and antifungal resistance by Krcmery V1, Barnes AJ. (PubMed)
(2) Pathogenicity and drug resistance in Candida albicans and other yeastspecies. A review by Mishra NN1, Prasad T, Sharma N, Payasi A, Prasad R, Gupta DK, Singh R.(PubMed)
(3) Multidrug resistance in yeast Candida by Prasad R1, Kapoor K.(PubMed)
(4) New evidence that Candida albicans possess additional ATP-binding cassette MDR-like genes: implications for antifungal azole resistance. by Walsh TJ1, Kasai M, Francesconi A, Landsman D, Chanock SJ. (PubMed)
(5) Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters. by Sanglard D1, Kuchler K, Ischer F, Pagani JL, Monod M, Bille J.(PubMed)
(6) Structural analysis of phospho-D-mannan-protein complexes isolated from yeast and mold form cells of Candida albicans NIH A-207 serotype A strain by Shibata N1, Fukasawa S, Kobayashi H, Tojo M, Yonezu T, Ambo A, Ohkubo Y, Suzuki S.(PubMed)
(7) The effect of antifungal combination on transcripts of a subset of drug-resistance genes in clinical isolates of Candida species induced biofilms by Ibrahim NH1, Melake NA2, Somily AM3, Zakaria AS4, Baddour MM5, Mahmoud AZ6(PubMed)
(8) Antifungal drug resistance in pathogenic fungi. by Vanden Bossche H1, Dromer F, Improvisi I, Lozano-Chiu M, Rex JH, Sanglard D.(PubMed)
(9) The genetic basis of fluconazole resistance development in Candida albicans by Morschhäuser J1.(PubMed)(10) A proteomic approach to understanding the development of multidrug-resistant Candida albicans strains by Kusch H1, Biswas K, Schwanfelder S, Engelmann S, Rogers PD, Hecker M, Morschhäuser J.(PubMed)
(187) Top 4 Most Dangerous Artificial Sweeteners(Fit day)(188) Treatment of Candida famata bloodstream infections: case series and review of the literature. Beyda ND1, Chuang SH, Alam MJ, Shah DN, Ng TM, McCaskey L, Garey KW.(PubMed)
(189) Food Additives And Preservatives(All food business)
(190) Candida Albicans andFood Additives(Candida Albicans cure)(191) Antibiotics exposure, risk factors, and outcomes with Candidaalbicans and non-Candida albicans candidemia. Results from a multi-center study. Wang H1, Wu DW, Han H, Yue JF, Zhang F, Shan TC, Guo HP, Yin M.(PubMed)
(192) Candida and Alcohol Abuse (Holistic health talk)(193) Control of state 3 respiration in liver mitochondria from rats subjected to chronic ethanol consumption. Spach PI1, Cunningham CC. (PubMed)
(194) The associations of alcohol drinking and drinking cessation to measures of the immune system in middle-aged men. Mili F1, Flanders WD, Boring JR, Annest JL, DeStefano F.(PubMed)
(195) Acute immunomodulatory effects of binge alcohol ingestion. Afshar M1, Richards S2, Mann D3, Cross A4, Smith GB5, Netzer G6, Kovacs E7, Hasday J. (PubMed) (196) Recombinagenicity of caffeine for Candida albican . Sarachek A1, Henderson LA. (PubMed)
(197) Effects of growth temperature and caffeine on genetic responses of Candida albicans to ethyl methanesulfonate, nitrous acid, and ultraviolet radiation. Sarachek A, Bish JT. (PubMed)
(198) Sugar, Dairy, Artificial Sweeteners and Candida albicans Infections(Candida Diet Foods)(199) Immunomodulatory strategies for celiac disease. Rossi M1, Maurano F, Luongo D.(PubMed)
(200) The effect of diet on systemic immune responses to wheat gliadin.
Johnson RB, LaBrooy JT, Shearman DJ, Davidson GP. (PubMed)(201) In mice, gluten in maternaldiet primes systemic immune responses to gliadin in offspring.Troncone R1, Ferguson A.(PubMed)(202) [Virulence of the opportunistic pathogen mushroom Candidaglabrata].[Article in Spanish] Castaño I1, Cormack B, De Las Peñas A.(PubMed)
(203) Condiments and the Candida Diet(Jiangsu, Shihuan bioengineer company)(204) Immunomodulation of mast cells by nutrients. Hagenlocher Y1, Lorentz A2. (PubMed)
(205) Effect of hypoxia on acetic acid ulcer of the stomach in rats with or without coenzyme Q10.
Kohli Y, Suto Y, Kodama T.(PubMed)
Sunday, February 28, 2021
Friday, February 26, 2021
Herbal Angelica Sinensis, A Promising Anti-Glioblastoma Drug
Cancers are the class of chronic and medical conditions characterized by cell growth disorderly and uncontrollably that start on the inner lining of the tissue of an organ due to the alternation of cell DNA.
At the advanced stage, most cancer cells can travel a distance away from the original site to infect other healthy tissue and organs through blood and fluids circulation.
Glioblastoma is one of the most aggressive cancers that begins within the brain, caused mostly by abnormal astrocytic cells and dead cells (necrosis). The disease is considered one of the most aggressive cancers induced by the alternation of cells originated from the brain, including the cerebral hemispheres.
According to statistics, most patients diagnosed with cancer die within 12 to 15 months. Less than 5% of patients are survived longer than five years.
If you are male you are at 1.5 higher risks of glioblastoma, compared to the female's counterpart.
The causes of glioblastoma are unknown, some researchers suggested that genetic preposition and environmental factors, previous radiotherapy, a weakened immune system may be some risk factors associated with the onset of the disease.
However, most cases of GBM are diagnosed at an older age with a median age of 64. Some researchers suggested that aging with the change of body function may be one of the major risk factors that cause the incidence.
Most patients with GBM experience symptoms of brain swelling caused by the overexpression of the fluid surrounding the tumor.
Conventionally, due to the nature of rapid growth, surgery is necessary to relieve the brain pressure and remove the tumor as much as possible, followed by radiation and chemotherapy.
Furthermore, the condition also shares the common symptoms of other types of cancer such as gastrointestinal discomforts accompanied by personality changes, and symptoms similar to those of a stroke.
On finding a natural ingredient for the prevention and treatment of neurological diseases, scientists examined the effects of Angelica Sinensis on glioblastoma multiforme (GBM).
Angelica or Dang Gui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.
The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.
According to tested analysis, Angelica sinensis accelerates apoptosis by their key substances influencing factors of apoptosis pathways, including
* Biochemical stress associated with cell death such as oxidative stress in the induction of cytotoxicity.
* Induced DNA damage to the cancer cells by enhancing the tumor suppressor protein such as p53.
* Lack of growth factors involved in cell proliferative and differentiation.
Based on the results, researchers suggest, "our review puts emphasis on the potential of natural products in GBM treatment by regulating multiple malignant cancer-related pathways solving pending problems such as reducing toxicity and side effect".
Taken altogether, Dandelion may be considered a remedy for the treatment of glioblastoma multiforme (GBM). pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Review of Natural Product-Derived Compounds as Potent Antiglioblastoma Drugs by Park MN1, Song HS2, Kim M1, Lee MJ1, Cho W1, Lee HJ1, Hwang CH1, Kim S1, Hwang Y1, Kang B1, Kim B. (PubMed)
At the advanced stage, most cancer cells can travel a distance away from the original site to infect other healthy tissue and organs through blood and fluids circulation.
Glioblastoma is one of the most aggressive cancers that begins within the brain, caused mostly by abnormal astrocytic cells and dead cells (necrosis). The disease is considered one of the most aggressive cancers induced by the alternation of cells originated from the brain, including the cerebral hemispheres.
According to statistics, most patients diagnosed with cancer die within 12 to 15 months. Less than 5% of patients are survived longer than five years.
If you are male you are at 1.5 higher risks of glioblastoma, compared to the female's counterpart.
The causes of glioblastoma are unknown, some researchers suggested that genetic preposition and environmental factors, previous radiotherapy, a weakened immune system may be some risk factors associated with the onset of the disease.
However, most cases of GBM are diagnosed at an older age with a median age of 64. Some researchers suggested that aging with the change of body function may be one of the major risk factors that cause the incidence.
Most patients with GBM experience symptoms of brain swelling caused by the overexpression of the fluid surrounding the tumor.
Conventionally, due to the nature of rapid growth, surgery is necessary to relieve the brain pressure and remove the tumor as much as possible, followed by radiation and chemotherapy.
Furthermore, the condition also shares the common symptoms of other types of cancer such as gastrointestinal discomforts accompanied by personality changes, and symptoms similar to those of a stroke.
On finding a natural ingredient for the prevention and treatment of neurological diseases, scientists examined the effects of Angelica Sinensis on glioblastoma multiforme (GBM).
Angelica or Dang Gui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.
The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.
According to tested analysis, Angelica sinensis accelerates apoptosis by their key substances influencing factors of apoptosis pathways, including
* Biochemical stress associated with cell death such as oxidative stress in the induction of cytotoxicity.
* Induced DNA damage to the cancer cells by enhancing the tumor suppressor protein such as p53.
* Lack of growth factors involved in cell proliferative and differentiation.
Based on the results, researchers suggest, "our review puts emphasis on the potential of natural products in GBM treatment by regulating multiple malignant cancer-related pathways solving pending problems such as reducing toxicity and side effect".
Taken altogether, Dandelion may be considered a remedy for the treatment of glioblastoma multiforme (GBM). pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Review of Natural Product-Derived Compounds as Potent Antiglioblastoma Drugs by Park MN1, Song HS2, Kim M1, Lee MJ1, Cho W1, Lee HJ1, Hwang CH1, Kim S1, Hwang Y1, Kang B1, Kim B. (PubMed)
Thursday, February 25, 2021
Cranberry Has No Effects on Urinary Disorders in Multiple Sclerosis (MS) Patients
Infection is an inflammatory condition caused by a microbial invasion on body tissues
Most cases of bacterial infection are treated with antibiotics. However, bacteria are very adaptable, overuse of antibiotics has been found to make them resistant to antibiotics.
Most common symptoms of bacterial infection include redness and heat, swelling, fever, pain at the site of infection.
Urinary tract infection (UTIs) mostly occurred in women is an infection that affects the bladder and urethra caused mostly by bacterial strains Escherichia coli (E. coli), commonly found in the gastrointestinal (GI) tract.
UTIs have been found to limit the function of the bladder and induce kidney infection.
The most common symptoms of urinary infection are persistent urge to urinate, urinary burning sensation, cloudy urine, and smelly urine.
In severe cases, patients may also experience symptoms of blood in the urine and bladder and pelvic pain.
The most common risk factors of urinary tract infection are gender, females are more like to have UTI comapred to males, sexual activity, use of birth control, and menopausal women.
Multiple sclerosis (MS) is a potentially disabling disease of the brain and spinal cord (central nervous system) casued by the immune system attacks the protective sheath (myelin) that covers nerve fibers.
MS causes communication problems between the brain and the rest of the body.
SHARON BEGLEY in examing the genetic preposition involved in MS wrote, " A newly discovered genetic mutation gives people who carry it a whopping 70 percent chance of developing multiple sclerosis, potentially opening the way toward new therapies for a debilitating neurological disorder whose ultimate cause has stumped researchers for decades".
The author continued, "The 70 percent chance of developing MS compares to a 0.1 percent risk in the general population, and the 100 or so previously known genetic variants increase the chance of MS to only about 0.3 percent at most, with no single gene packing much of a punch".
In other words, people having certain genes inherited from the parent are at a substantial risk of MS developing comapred to people who do not.
According to the statistics, in 2010/2011, approximately 93,500 Canadians were diagnosed with the disease or 290 cases per 100,000 population. Believe it or not, MS is the most prevalent in Canada comapred to other parts of the world.
Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.
On finding a potential compound for the prevention of urinary infections, researchers examined the effect of cranberry extract (CE) in multiple sclerosis (MS) patients suffering from urinary disorders.
The prospective, double-blind study included a total of 171 adult MS outpatients with urinary disorders presenting at eight centers received either cranberry extract ((36 mg proanthocyanidins per day) or matching placebo for a year.
According to the results of follow up, the were no difference between cranberry and placebo).
In other words, there was no difference in time to first symptomatic UTI distribution across 1 year, with an estimated hazard ratio of 0.99, 95% CI [0.61, 1.60] (p = 0.97).
Furthermore, the econdary endpoints and tolerance also did not differ between groups.
Based on the findings, researchers aid, "Taking cranberry extract versus placebo twice a day did not prevent UTI occurrence in MS patients with urinary disorders".
Taken altogether, cranberry can not be considered a remedy for the prevention and treatment of urinary disorders in MS patients, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cranberry versus placebo in the prevention of urinary infections in multiple sclerosis: a multicenter, randomized, placebo-controlled, double-blind trial by Gallien P1, Amarenco G2, Benoit N3, Bonniaud V4, Donzé C5, Kerdraon J6, de Seze M7, Denys P8, Renault A9, Naudet F10, Reymann JM. (PubMed)
(2) Discovery of multiple sclerosis gene could inspire new therapies — if it’s right by By SHARON BEGLEY
Most cases of bacterial infection are treated with antibiotics. However, bacteria are very adaptable, overuse of antibiotics has been found to make them resistant to antibiotics.
Most common symptoms of bacterial infection include redness and heat, swelling, fever, pain at the site of infection.
Urinary tract infection (UTIs) mostly occurred in women is an infection that affects the bladder and urethra caused mostly by bacterial strains Escherichia coli (E. coli), commonly found in the gastrointestinal (GI) tract.
UTIs have been found to limit the function of the bladder and induce kidney infection.
The most common symptoms of urinary infection are persistent urge to urinate, urinary burning sensation, cloudy urine, and smelly urine.
In severe cases, patients may also experience symptoms of blood in the urine and bladder and pelvic pain.
The most common risk factors of urinary tract infection are gender, females are more like to have UTI comapred to males, sexual activity, use of birth control, and menopausal women.
Multiple sclerosis (MS) is a potentially disabling disease of the brain and spinal cord (central nervous system) casued by the immune system attacks the protective sheath (myelin) that covers nerve fibers.
MS causes communication problems between the brain and the rest of the body.
SHARON BEGLEY in examing the genetic preposition involved in MS wrote, " A newly discovered genetic mutation gives people who carry it a whopping 70 percent chance of developing multiple sclerosis, potentially opening the way toward new therapies for a debilitating neurological disorder whose ultimate cause has stumped researchers for decades".
The author continued, "The 70 percent chance of developing MS compares to a 0.1 percent risk in the general population, and the 100 or so previously known genetic variants increase the chance of MS to only about 0.3 percent at most, with no single gene packing much of a punch".
In other words, people having certain genes inherited from the parent are at a substantial risk of MS developing comapred to people who do not.
According to the statistics, in 2010/2011, approximately 93,500 Canadians were diagnosed with the disease or 290 cases per 100,000 population. Believe it or not, MS is the most prevalent in Canada comapred to other parts of the world.
Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.
On finding a potential compound for the prevention of urinary infections, researchers examined the effect of cranberry extract (CE) in multiple sclerosis (MS) patients suffering from urinary disorders.
The prospective, double-blind study included a total of 171 adult MS outpatients with urinary disorders presenting at eight centers received either cranberry extract ((36 mg proanthocyanidins per day) or matching placebo for a year.
According to the results of follow up, the were no difference between cranberry and placebo).
In other words, there was no difference in time to first symptomatic UTI distribution across 1 year, with an estimated hazard ratio of 0.99, 95% CI [0.61, 1.60] (p = 0.97).
Furthermore, the econdary endpoints and tolerance also did not differ between groups.
Based on the findings, researchers aid, "Taking cranberry extract versus placebo twice a day did not prevent UTI occurrence in MS patients with urinary disorders".
Taken altogether, cranberry can not be considered a remedy for the prevention and treatment of urinary disorders in MS patients, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cranberry versus placebo in the prevention of urinary infections in multiple sclerosis: a multicenter, randomized, placebo-controlled, double-blind trial by Gallien P1, Amarenco G2, Benoit N3, Bonniaud V4, Donzé C5, Kerdraon J6, de Seze M7, Denys P8, Renault A9, Naudet F10, Reymann JM. (PubMed)
(2) Discovery of multiple sclerosis gene could inspire new therapies — if it’s right by By SHARON BEGLEY
Wednesday, February 24, 2021
Fennel, The Best Herbal Remedy Which Detoxes Your Kidneys Through Promoting Excess Fluids Secretion, Public Medical Library Revealed
Fennel may have a potential and positive effect of eliminating excess water and toxin from our body, some scientists suggested.
Diuresis is a medicine with a function to stimulate increased production of urine.
Detoxification is a process of eliminated toxin accumulation from our body. In some cases, the function may only target some specific organs, such as kidneys, liver,..... and lung.
According to traditional medicine, detoxification is a necessary process to enhance and optimize the functions of our body by cleansing away substances that may reduce or cause harm to our body organs and tissue.
According to the Tao of Wellness in the address of the importance of detoxification of Traditional Chinese Medicine wrote, " Our body is automatically programmed to cleanse itself daily. However, with our fast-paced modern lifestyle and exposure to an increasing number of harmful and toxic substances, our body’s natural cleansing ability has become overworked and compromised" and "Many signs and symptoms attributed to stress are now being linked to exposure from harmful substances such as PCBs, pesticides, herbicides, antibiotics, growth hormones, and mercury in food and liquids as well as dioxins and formaldehyde in the air".
Truly, harmful and toxic substances not removed from our body may have substantially negative implications to cause many serious illnesses, such as cancer, neurodegenerative diseases,..... and reproductive ailments.
Fennel (Foeniculum vulgare) is a plant species of the genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean.
The herb or food has been used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, regulate the menstrual cycle, and relieve PMS,...
Nutrients
1. Carbohydrates
2. Fiber
3. Protein
4. Thiamine (Vitamin B1)
5. Riboflavin (Vitamin B2)
6. Niacin (Vitamin B3)
7. Pantothenic acid (B5)
8. Vitamin B6
9. Folate (Vitamin B9)
10. Vitamin C
11. Calcium
12. Copper
13. Iron
14. Magnesium
15. Molybdenum
16. Phosphorus
17. Potassium
18. Zinc
19. Etc.
In an animal model, according to the John Wiley & Sons, Ltd. in the evaluation of the re-toxic effect of hydroalcoholic extracts of Foeniculum vulgare var dulce (D.C) root, researchers found that application of the extract exerts a significant activity in flushing out of excess water and toxin from the body through increased kidney function in secretion of fluids.
The result of these properties was observed by an increase in urine flow and urinary sodium excretion.
The efficacy in the cleansing body was also found linearly in dose depending manner.
Continuously, in further examine the efficacy of fennel powder, extract, and oil on gentamicin-induced nephrotoxicity through a study of a total of 35 adult female Sprague Dawley rats classified into five groups with the first group kept on the standard diet all over the period of the experiment. and the other groups administered gentamicin (100 mg/kg/day for 7 days i.p), followed by either control (+ve) group or treated groups with fennel powder, extract, and oil for 45 days, at the end of the study, researchers found that
* Injected gentamicin group served as control exhibited strong nephrotoxicity manifested by increasing levels of kidney function indicator, serum nitric oxide (NO), and kidney malondialde(MDA) however, this group of rats also exerted a significant decrease in weight gain.
Increased expression of serum nitric oxide (NO) and kidney malondialdehyde (MDA) is an indicator of severe oxidative stress caused by an imbalanced ratio of ROS and antioxidants in the host.
* Gentamicin groups treated with fennel powder, extract and oil demonstrated an improved level of urea and uric acid in comparison to control (+ve) and displayed an improvement of antioxidant enzymes, serum superoxide dismutase(SOD), catalase, and glutathione transferase (GST) and decrease of serum NO in compared to control (+ve) group.
These results addressed the important antioxidant effect of fennel extracts.
Furthermore, the applications not only inhibited the levels of free radicals and theirs' chain reactive activities but also stimulated the production of antioxidants found in the host tissue.
* Moreover, the group treated with fennel oil restored the normal values of kidney antioxidant enzymes compared with the normal group and other treatment groups.
Dr. Soheir Ahamed Al-Masri, the lead author, after taking into account other co and confounders said, "fennel powder, extract and oil have a potent antioxidant and ameliorate in rats gentamicin-induced nephrotoxicity in rats".
Clearly, fennel oil exhibited the greatest effect in stimulated kidney function to detox the body toxins through increased secretion of urine compared to other experimental groups.
The results of this study clearly indicate that fennel powder, extract and oil are potent antioxidants that ameliorate the levels of gentamicin-induced nephrotoxicity in rats.
Interestingly, in spontaneously hypertensive rats (SHR) treated with either water extract of Marrubium vulgare L. or Foeniculum vulgare L. in normotensive Wistar-Kyoto rats (WKY), researchers showed that application of fennel water extract reduces hypertension through Foeniculum increased water, sodium, and potassium excretion in compared to no effect of Marrubium treated group.
Additionally, in comparison to Marrubium extract reduced hypertension through inhibited contractile responses, fennel restored the normal; blood pressure by increased urine secretion and ameliorated the overexpression of ROS and increased antioxidant status in the host.
Surely, one can say that Foeniculum acts mainly as a diuretic and a natriuretic while Marrubium displays vascular relaxant activity.
Taken together, fennel and its extracts may be considered as a kidney detoxed functional food in getting rid of body toxins through its diuretic activities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Diuretic action of hydroalcohol extracts oilFoeniculum vulgare var dulce (D.C.) roots in rats by
D. Beaux, J. Fleurentin and F. Mortier(Wiley Online Library)
(2) The Ameliorating Effects of Fennel Powder, Extract and Oil on Gentamicin Induced Nephrotoxicity in Rats 1 Soheir Ahamed Al-Masri and 2 Waffa, Sh. Ali( Journal of American Science)
(3) Pharmacological evidence of hypotensive activity of Marrubium vulgare and Foeniculum vulgare in spontaneously hypertensive rat by El Bardai S1, Lyoussi B, Wibo M, Morel N(PubMed)
Diuresis is a medicine with a function to stimulate increased production of urine.
Detoxification is a process of eliminated toxin accumulation from our body. In some cases, the function may only target some specific organs, such as kidneys, liver,..... and lung.
According to traditional medicine, detoxification is a necessary process to enhance and optimize the functions of our body by cleansing away substances that may reduce or cause harm to our body organs and tissue.
According to the Tao of Wellness in the address of the importance of detoxification of Traditional Chinese Medicine wrote, " Our body is automatically programmed to cleanse itself daily. However, with our fast-paced modern lifestyle and exposure to an increasing number of harmful and toxic substances, our body’s natural cleansing ability has become overworked and compromised" and "Many signs and symptoms attributed to stress are now being linked to exposure from harmful substances such as PCBs, pesticides, herbicides, antibiotics, growth hormones, and mercury in food and liquids as well as dioxins and formaldehyde in the air".
Truly, harmful and toxic substances not removed from our body may have substantially negative implications to cause many serious illnesses, such as cancer, neurodegenerative diseases,..... and reproductive ailments.
Fennel (Foeniculum vulgare) is a plant species of the genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean.
The herb or food has been used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, regulate the menstrual cycle, and relieve PMS,...
Nutrients
1. Carbohydrates
2. Fiber
3. Protein
4. Thiamine (Vitamin B1)
5. Riboflavin (Vitamin B2)
6. Niacin (Vitamin B3)
7. Pantothenic acid (B5)
8. Vitamin B6
9. Folate (Vitamin B9)
10. Vitamin C
11. Calcium
12. Copper
13. Iron
14. Magnesium
15. Molybdenum
16. Phosphorus
17. Potassium
18. Zinc
19. Etc.
In an animal model, according to the John Wiley & Sons, Ltd. in the evaluation of the re-toxic effect of hydroalcoholic extracts of Foeniculum vulgare var dulce (D.C) root, researchers found that application of the extract exerts a significant activity in flushing out of excess water and toxin from the body through increased kidney function in secretion of fluids.
The result of these properties was observed by an increase in urine flow and urinary sodium excretion.
The efficacy in the cleansing body was also found linearly in dose depending manner.
Continuously, in further examine the efficacy of fennel powder, extract, and oil on gentamicin-induced nephrotoxicity through a study of a total of 35 adult female Sprague Dawley rats classified into five groups with the first group kept on the standard diet all over the period of the experiment. and the other groups administered gentamicin (100 mg/kg/day for 7 days i.p), followed by either control (+ve) group or treated groups with fennel powder, extract, and oil for 45 days, at the end of the study, researchers found that
* Injected gentamicin group served as control exhibited strong nephrotoxicity manifested by increasing levels of kidney function indicator, serum nitric oxide (NO), and kidney malondialde(MDA) however, this group of rats also exerted a significant decrease in weight gain.
Increased expression of serum nitric oxide (NO) and kidney malondialdehyde (MDA) is an indicator of severe oxidative stress caused by an imbalanced ratio of ROS and antioxidants in the host.
* Gentamicin groups treated with fennel powder, extract and oil demonstrated an improved level of urea and uric acid in comparison to control (+ve) and displayed an improvement of antioxidant enzymes, serum superoxide dismutase(SOD), catalase, and glutathione transferase (GST) and decrease of serum NO in compared to control (+ve) group.
These results addressed the important antioxidant effect of fennel extracts.
Furthermore, the applications not only inhibited the levels of free radicals and theirs' chain reactive activities but also stimulated the production of antioxidants found in the host tissue.
* Moreover, the group treated with fennel oil restored the normal values of kidney antioxidant enzymes compared with the normal group and other treatment groups.
Dr. Soheir Ahamed Al-Masri, the lead author, after taking into account other co and confounders said, "fennel powder, extract and oil have a potent antioxidant and ameliorate in rats gentamicin-induced nephrotoxicity in rats".
Clearly, fennel oil exhibited the greatest effect in stimulated kidney function to detox the body toxins through increased secretion of urine compared to other experimental groups.
The results of this study clearly indicate that fennel powder, extract and oil are potent antioxidants that ameliorate the levels of gentamicin-induced nephrotoxicity in rats.
Interestingly, in spontaneously hypertensive rats (SHR) treated with either water extract of Marrubium vulgare L. or Foeniculum vulgare L. in normotensive Wistar-Kyoto rats (WKY), researchers showed that application of fennel water extract reduces hypertension through Foeniculum increased water, sodium, and potassium excretion in compared to no effect of Marrubium treated group.
Additionally, in comparison to Marrubium extract reduced hypertension through inhibited contractile responses, fennel restored the normal; blood pressure by increased urine secretion and ameliorated the overexpression of ROS and increased antioxidant status in the host.
Surely, one can say that Foeniculum acts mainly as a diuretic and a natriuretic while Marrubium displays vascular relaxant activity.
Taken together, fennel and its extracts may be considered as a kidney detoxed functional food in getting rid of body toxins through its diuretic activities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Diuretic action of hydroalcohol extracts oilFoeniculum vulgare var dulce (D.C.) roots in rats by
D. Beaux, J. Fleurentin and F. Mortier(Wiley Online Library)
(2) The Ameliorating Effects of Fennel Powder, Extract and Oil on Gentamicin Induced Nephrotoxicity in Rats 1 Soheir Ahamed Al-Masri and 2 Waffa, Sh. Ali( Journal of American Science)
(3) Pharmacological evidence of hypotensive activity of Marrubium vulgare and Foeniculum vulgare in spontaneously hypertensive rat by El Bardai S1, Lyoussi B, Wibo M, Morel N(PubMed)
Tuesday, February 23, 2021
Bromelain, Processes Cytotoxic Property Against Peritoneal Mesothelioma
Peritoneal mesothelioma is a medical condition characterized by irregular cell growth in the tissues of the abdomen (the peritoneum).
Most cases of peritoneal mesothelioma begin in the cell in the surface of the inner lining of the peritoneum, before penetrating into the deeper layers.
At the early stage, due to the small size of the tumor, patients with peritoneal mesothelioma are asymptomatic.
However, at the later stage, patients may experience symptoms of abdominal pain or swelling due to the larger size tumor has pressed on the nearby nerves tissues and blood vessels, changes in bowel habits, feeling of fullness, and night sweat accompanied by the general symptoms shared by other types of cancer, such as unexplained weight loss, gastrointestinal discomforts, and loss of appetite.
According to the statistics provided by the American Cancer Society, compared to other types of cancer mesothelioma is rare, with approximately 2,000 to 3,000 new cases of mesothelioma in the US each year. The asbestos-related mesothelioma only accounts for less than 0.3 percent of all cancer diagnosed in the country.
Peritoneal mesothelioma accounts for less than 20 percent of all mesothelioma cases.
Dr. Rodolfo Fonte, the lead scientist in the examination of the risk of asbestos-induced peritoneal mesothelioma in a construction worker, wrote, "Peritoneal mesothelioma is a rare and aggressive asbestos-related malignancy. We present the case of a 65-year-old man who developed recurrent ascites after having been exposed to asbestos in the building industry for > 40 years".
And, "Occupational history and immunohistochemistry are helpful for the correct diagnosis, which, in turn, is important in relation to prognosis and treatment (adoption of new integrated procedures that seem to promise prolonged survival and increased quality of life), and in relation to medico-legal issues and occupation-related compensation claims following asbestos exposure".
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
With an aim to find a natural ingredient for the treatment of peritoneal mesothelioma, researchers examined the effects of Bromelain (cysteine proteinase) effects on Mucin 1 (MUC1), a glycosylation-dependent protein that confers tumors with invasiveness, metastasis, and chemoresistance.
In the study in which researchers compared the efficacy with the application of various concentrations of bromelain and after 4 and 72 h and combinations of bromelain and cytotoxic drugs (cisplatin or 5-FU) at 72 h, MUC1-expressing MPM cell lines found that bromelain increased the cytotoxicity of cisplatin significantly in cell lines.
Compared to the aforementioned inhibition, combining fluorouracil with bromelain did not show a significant increase in cytotoxicity.
In other words, bromelain improves the chemotherapy depending totally on the types of drugs used for the treatment of peritoneal mesothelioma.
Furthermore, bromelain used alone also showed a significant effect in inducing cell death by apoptosis and autophagy.
On pancreatic and breast cancer cells, injection of bromelain also adversely affected the viability of MUC1 expressing on both cell lines.
Based on the findings, Bromelain used alone or combined with other chemo drugs might have a strong effect on the barrier function of MUC1.
Collectively, bromelain inhibited the progression and proliferation of peritoneal mesothelioma by blocking the activity of the gene MUC1.
Dr. Pillai K, the lead scientist said, " current evidence indicates that bromelain may have the potential of being developed into an effective anticancer agent for MPM".
Taken altogether, bromelain may be considered supplements for the prevention and treatment of peritoneal mesothelioma, pending the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Anticancer effect of bromelain with and without cisplatin or 5-FU on malignant peritoneal mesothelioma cells by Pillai K1, Ehteda A, Akhter J, Chua TC, Morris DL. (PubMed)
(2) Anticancer property of bromelain with therapeutic potential in malignant peritoneal mesothelioma by Pillai K1, Akhter J, Chua TC, Morris DL. (PubMed)
(3) Asbestos-induced peritoneal mesothelioma in a construction worker by Rodolfo Fonte, Salvatore Gambettino, Mario Melazzini, Mario Scelsi, Claudio Zanon, andStefano M Candura. (PMC)
Most cases of peritoneal mesothelioma begin in the cell in the surface of the inner lining of the peritoneum, before penetrating into the deeper layers.
At the early stage, due to the small size of the tumor, patients with peritoneal mesothelioma are asymptomatic.
However, at the later stage, patients may experience symptoms of abdominal pain or swelling due to the larger size tumor has pressed on the nearby nerves tissues and blood vessels, changes in bowel habits, feeling of fullness, and night sweat accompanied by the general symptoms shared by other types of cancer, such as unexplained weight loss, gastrointestinal discomforts, and loss of appetite.
According to the statistics provided by the American Cancer Society, compared to other types of cancer mesothelioma is rare, with approximately 2,000 to 3,000 new cases of mesothelioma in the US each year. The asbestos-related mesothelioma only accounts for less than 0.3 percent of all cancer diagnosed in the country.
Peritoneal mesothelioma accounts for less than 20 percent of all mesothelioma cases.
Dr. Rodolfo Fonte, the lead scientist in the examination of the risk of asbestos-induced peritoneal mesothelioma in a construction worker, wrote, "Peritoneal mesothelioma is a rare and aggressive asbestos-related malignancy. We present the case of a 65-year-old man who developed recurrent ascites after having been exposed to asbestos in the building industry for > 40 years".
And, "Occupational history and immunohistochemistry are helpful for the correct diagnosis, which, in turn, is important in relation to prognosis and treatment (adoption of new integrated procedures that seem to promise prolonged survival and increased quality of life), and in relation to medico-legal issues and occupation-related compensation claims following asbestos exposure".
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
With an aim to find a natural ingredient for the treatment of peritoneal mesothelioma, researchers examined the effects of Bromelain (cysteine proteinase) effects on Mucin 1 (MUC1), a glycosylation-dependent protein that confers tumors with invasiveness, metastasis, and chemoresistance.
In the study in which researchers compared the efficacy with the application of various concentrations of bromelain and after 4 and 72 h and combinations of bromelain and cytotoxic drugs (cisplatin or 5-FU) at 72 h, MUC1-expressing MPM cell lines found that bromelain increased the cytotoxicity of cisplatin significantly in cell lines.
Compared to the aforementioned inhibition, combining fluorouracil with bromelain did not show a significant increase in cytotoxicity.
In other words, bromelain improves the chemotherapy depending totally on the types of drugs used for the treatment of peritoneal mesothelioma.
Furthermore, bromelain used alone also showed a significant effect in inducing cell death by apoptosis and autophagy.
On pancreatic and breast cancer cells, injection of bromelain also adversely affected the viability of MUC1 expressing on both cell lines.
Based on the findings, Bromelain used alone or combined with other chemo drugs might have a strong effect on the barrier function of MUC1.
Collectively, bromelain inhibited the progression and proliferation of peritoneal mesothelioma by blocking the activity of the gene MUC1.
Dr. Pillai K, the lead scientist said, " current evidence indicates that bromelain may have the potential of being developed into an effective anticancer agent for MPM".
Taken altogether, bromelain may be considered supplements for the prevention and treatment of peritoneal mesothelioma, pending the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Anticancer effect of bromelain with and without cisplatin or 5-FU on malignant peritoneal mesothelioma cells by Pillai K1, Ehteda A, Akhter J, Chua TC, Morris DL. (PubMed)
(2) Anticancer property of bromelain with therapeutic potential in malignant peritoneal mesothelioma by Pillai K1, Akhter J, Chua TC, Morris DL. (PubMed)
(3) Asbestos-induced peritoneal mesothelioma in a construction worker by Rodolfo Fonte, Salvatore Gambettino, Mario Melazzini, Mario Scelsi, Claudio Zanon, andStefano M Candura. (PMC)
Monday, February 22, 2021
Herbal Bilberry Protects the Skin Against Allergic Contact Dermatitis
Contact dermatitis is a skin condition with symptoms of a red, itchy rash caused by direct contact with a substance or an immune overreaction against contact allergens.
Many chemicals and nonchemicals substances have been found to induce such abnormal reactions, including cosmetics, fragrances, jewelry, and plants.
Most cases of contact dermatitis are nonlife-threatening, however, the condition can induce certain discomforts, particularly in people with an allergic reaction to other conditions.
Contact dermatitis can be healed within a week or 2. The condition can be preventable if the cause is identified.
Besides the common symptoms of a red, itchy rash on the skin, some people may experience more serious symptoms including crusting swelling, burning, or tender skin.
Dr. Imbesi S, the lead scientist in the explanation of the immune involvement of the allergic contact dermatitis wrote, " an inflammatory skin condition due to pro-inflammatory and toxic factors able to activate the skin innate immunity (irritant contact dermatitis) or caused by a T-cell- mediated hypersensitivity reaction (allergic contact dermatitis)".
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belongings to the family Ericaceae, native to Northern Europe.
The plant berry has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
In the urgency to find a natural ingredient for the treatment of chronic allergic contact dermatitis with no side effects, researchers examined the bilberry extract (Bilberon-25) in the alleviation of pruritus in a mouse model of chronic allergic contact dermatitis.
The study involved BALB/c mice with chronic allergic contact dermatitis induced by 3 weeks of repeated application of 2,4,6-trinitro-1-chlorobenzene (TNCB) following by the administration of Bilberon-25 orally for 3 weeks after sensitization with TNCB.
During the experiment, administered Bilberon-25 orally significantly attenuated the TNCB-induced increase in scratching behavior, compared to that of dexamethasone.
Both Bilberon-25 and dexamethasone inhibited the ear swelling.
Additional differentiation of the Bilberon-25 efficacy, the action of the herbal remedy inhibited symptoms of chronic allergic contact dermatitis by alleviating T helper cell type 2 (Th2) predominance of the lesional skin.
Based on the findings, researchers wrote in the final report, "Anthocyanins from bilberry might be beneficial for the treatment of chronic pruritus which can occur in patients with inflammatory skin diseases such as atopic dermatitis".
In order to reveal more information about anthocyanin activity against chronic allergic contact dermatitis, researchers at the Chiba Univ compared the anti-pruritic effect of anthocyanin-rich quality-controlled bilberry extract and anthocyanidin-rich degraded extract in a mouse model of allergic contact dermatitis.
Once again, BALB/c mice with allergic contact dermatitis induced by 4 weeks of repeated application of 2,4,6-trinitro-1-chlorobenzene (TNCB) following by administration of Bilberon-25 orally for 4 weeks.
Compared with nonheated Bilberon-25, the proportion of anthocyanins in heated Bilberon-25 decreased, and the proportion of anthocyanidins was increased in a heated-time-dependent manner.
Treatment with non-heated Bilberon-25 significantly attenuated the TNCB-induced increased scratching behavior, whereas treatment with 2 h-heated Bilberon-25 did not.
Particularly, 300 μg/mL nonheated Bilberon-25 showed significant inhibition of degranulation in RBL-2H3 mast cells.
The results suggested that the anthocyanin-rich but not anthocyanidin-rich bilberry extract inhibited the skin diseases involving pruritic symptoms, such as chronic allergic contact dermatitis, atopic dermatitis, and rhinitis.
Taken altogether, bilberry processed abundantly bioactive compound anthocyanoside may be considered a functioning remedy for the treatment of symptoms in patients with chronic allergic contact dermatitis, pending the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Anthocyanins from bilberry (Vaccinium myrtillus L.) alleviate pruritus in a mouse model of chronic allergic contact dermatitis by Yamaura K1, Shimada M, Ueno K. (PubMed)
(2) Anthocyanins, but not anthocyanidins, from bilberry (Vaccinium myrtillus L.) alleviate pruritus via inhibition of mast cell degranulation by Yamaura K1, Ishiwatari M, Yamamoto M, Shimada M, Bi Y, Ueno K. (PubMed)
(3) Allergic contact dermatitis: immune system involvement and distinctive clinical cases by Imbesi S1, Minciullo PL, Isola S, Gangemi S. (PubMed)
Many chemicals and nonchemicals substances have been found to induce such abnormal reactions, including cosmetics, fragrances, jewelry, and plants.
Most cases of contact dermatitis are nonlife-threatening, however, the condition can induce certain discomforts, particularly in people with an allergic reaction to other conditions.
Contact dermatitis can be healed within a week or 2. The condition can be preventable if the cause is identified.
Besides the common symptoms of a red, itchy rash on the skin, some people may experience more serious symptoms including crusting swelling, burning, or tender skin.
Dr. Imbesi S, the lead scientist in the explanation of the immune involvement of the allergic contact dermatitis wrote, " an inflammatory skin condition due to pro-inflammatory and toxic factors able to activate the skin innate immunity (irritant contact dermatitis) or caused by a T-cell- mediated hypersensitivity reaction (allergic contact dermatitis)".
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belongings to the family Ericaceae, native to Northern Europe.
The plant berry has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
In the urgency to find a natural ingredient for the treatment of chronic allergic contact dermatitis with no side effects, researchers examined the bilberry extract (Bilberon-25) in the alleviation of pruritus in a mouse model of chronic allergic contact dermatitis.
The study involved BALB/c mice with chronic allergic contact dermatitis induced by 3 weeks of repeated application of 2,4,6-trinitro-1-chlorobenzene (TNCB) following by the administration of Bilberon-25 orally for 3 weeks after sensitization with TNCB.
During the experiment, administered Bilberon-25 orally significantly attenuated the TNCB-induced increase in scratching behavior, compared to that of dexamethasone.
Both Bilberon-25 and dexamethasone inhibited the ear swelling.
Additional differentiation of the Bilberon-25 efficacy, the action of the herbal remedy inhibited symptoms of chronic allergic contact dermatitis by alleviating T helper cell type 2 (Th2) predominance of the lesional skin.
Based on the findings, researchers wrote in the final report, "Anthocyanins from bilberry might be beneficial for the treatment of chronic pruritus which can occur in patients with inflammatory skin diseases such as atopic dermatitis".
In order to reveal more information about anthocyanin activity against chronic allergic contact dermatitis, researchers at the Chiba Univ compared the anti-pruritic effect of anthocyanin-rich quality-controlled bilberry extract and anthocyanidin-rich degraded extract in a mouse model of allergic contact dermatitis.
Once again, BALB/c mice with allergic contact dermatitis induced by 4 weeks of repeated application of 2,4,6-trinitro-1-chlorobenzene (TNCB) following by administration of Bilberon-25 orally for 4 weeks.
Compared with nonheated Bilberon-25, the proportion of anthocyanins in heated Bilberon-25 decreased, and the proportion of anthocyanidins was increased in a heated-time-dependent manner.
Treatment with non-heated Bilberon-25 significantly attenuated the TNCB-induced increased scratching behavior, whereas treatment with 2 h-heated Bilberon-25 did not.
Particularly, 300 μg/mL nonheated Bilberon-25 showed significant inhibition of degranulation in RBL-2H3 mast cells.
The results suggested that the anthocyanin-rich but not anthocyanidin-rich bilberry extract inhibited the skin diseases involving pruritic symptoms, such as chronic allergic contact dermatitis, atopic dermatitis, and rhinitis.
Taken altogether, bilberry processed abundantly bioactive compound anthocyanoside may be considered a functioning remedy for the treatment of symptoms in patients with chronic allergic contact dermatitis, pending the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Anthocyanins from bilberry (Vaccinium myrtillus L.) alleviate pruritus in a mouse model of chronic allergic contact dermatitis by Yamaura K1, Shimada M, Ueno K. (PubMed)
(2) Anthocyanins, but not anthocyanidins, from bilberry (Vaccinium myrtillus L.) alleviate pruritus via inhibition of mast cell degranulation by Yamaura K1, Ishiwatari M, Yamamoto M, Shimada M, Bi Y, Ueno K. (PubMed)
(3) Allergic contact dermatitis: immune system involvement and distinctive clinical cases by Imbesi S1, Minciullo PL, Isola S, Gangemi S. (PubMed)
Sunday, February 21, 2021
Angelica Sinensis May Improve the Body's Blood Circulation
Blood is a body fluid that delivers necessary nutrients and oxygen to the cells and transports metabolic waste products away from those same cells.
The heart formed part of the circulatory system is a muscular organ that pumps blood through the blood vessels to nourish the body tissues and organs.
The circulatory or cardiovascular system delivers nutrients and oxygen to all cells in the body, consisting of the heart and the blood vessels in the body.
More precisely, there are 2 types of large vessel
* The arteries carry blood away from the heart.
*The veins carry the blood back to the heart.
Blood pressure is the force of blood pushing against the walls of the arteries as the heart pumps out blood. High blood pressure means raising the pressure in your heart and staying high over time, damaging the body in many ways.
Most cases of heart dysfunction are associated with the reduced function of the heart muscle, leading to reduce blood flow that facilitates heart failure and the backup of blood into the lungs or rest of the body.
Heart disease is a condition in which the heart's inner lining of blood vessels is served damage that can impede the function of transportation of oxygen and nutrition of the heart to other cells and organs in the body.
Every day, more than 2,000 Americans die as a result of heart diseases. Approximately 60 million Americans have heart disease.
Believe it or not, 1 in 4 women in the US dies from heart diseases and coronary heart diseases.
The most common heart diseases associated with blood circulation are
* Heart diseases are affected by the arteries to the heart, such as coronary heart disease.
which is a condition of blockage of blood flow in the arteries, as a result of hardening arterial wall, cholesterol building up, chemicals, such as cadmium clog up arteries, etc. causes of narrowing coronary arteries.
* Heart diseases are affected by heart valves function in regulating blood flow such as valvular heart disease.
According to the statistics, heart disease is the leading cause of death in the US, approximately 610,000 people die of heart disease every year.
On finding a natural ingredient for the prevention and treatment of heart diseases, scientists examined the alcohol (Jiu Danggui, JDG) and charred DG are the main processed products of Angelica sinensis (Danggui, DG) on blood stasis syndrome (BSS).
Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.
The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.
According to the analysis of the results of hemorheology, coagulation function parameters and metabolomics,
* In BSS model, JD demonstrated the best in DGPPs intervention in significant relief rats' BSS.
* DGPP intervention showed different degrees of reverse effect on these metabolites associated with the expression of the syndrome in the tested model, and
* JDG was found to be the most effective owing to the extensive regulation effect on differential metabolites.
Based on the results, researchers suggest, "This study provides a reference for understanding the pathological mechanism of BSS and the mechanism of DGPPs, which lays a theoretical foundation for the rational use of DGPPs in clinical practice".
Taken altogether, Dandelion may be considered a remedy for the treatment of blood stasis syndrome (BSS), pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Metabolomics study on promoting blood circulation and ameliorating blood stasis: Investigating the mechanism of Angelica sinensis and its processed products by Yuan Z1, Zhong L1, Hua Y1, Ji P1, Yao W1, Ma Q1, Zhang X1, Wen Y1, Yang L1, Wei Y. (PubMed)
The heart formed part of the circulatory system is a muscular organ that pumps blood through the blood vessels to nourish the body tissues and organs.
The circulatory or cardiovascular system delivers nutrients and oxygen to all cells in the body, consisting of the heart and the blood vessels in the body.
More precisely, there are 2 types of large vessel
* The arteries carry blood away from the heart.
*The veins carry the blood back to the heart.
Blood pressure is the force of blood pushing against the walls of the arteries as the heart pumps out blood. High blood pressure means raising the pressure in your heart and staying high over time, damaging the body in many ways.
Most cases of heart dysfunction are associated with the reduced function of the heart muscle, leading to reduce blood flow that facilitates heart failure and the backup of blood into the lungs or rest of the body.
Heart disease is a condition in which the heart's inner lining of blood vessels is served damage that can impede the function of transportation of oxygen and nutrition of the heart to other cells and organs in the body.
Every day, more than 2,000 Americans die as a result of heart diseases. Approximately 60 million Americans have heart disease.
Believe it or not, 1 in 4 women in the US dies from heart diseases and coronary heart diseases.
The most common heart diseases associated with blood circulation are
* Heart diseases are affected by the arteries to the heart, such as coronary heart disease.
which is a condition of blockage of blood flow in the arteries, as a result of hardening arterial wall, cholesterol building up, chemicals, such as cadmium clog up arteries, etc. causes of narrowing coronary arteries.
* Heart diseases are affected by heart valves function in regulating blood flow such as valvular heart disease.
According to the statistics, heart disease is the leading cause of death in the US, approximately 610,000 people die of heart disease every year.
On finding a natural ingredient for the prevention and treatment of heart diseases, scientists examined the alcohol (Jiu Danggui, JDG) and charred DG are the main processed products of Angelica sinensis (Danggui, DG) on blood stasis syndrome (BSS).
Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.
The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.
According to the analysis of the results of hemorheology, coagulation function parameters and metabolomics,
* In BSS model, JD demonstrated the best in DGPPs intervention in significant relief rats' BSS.
* DGPP intervention showed different degrees of reverse effect on these metabolites associated with the expression of the syndrome in the tested model, and
* JDG was found to be the most effective owing to the extensive regulation effect on differential metabolites.
Based on the results, researchers suggest, "This study provides a reference for understanding the pathological mechanism of BSS and the mechanism of DGPPs, which lays a theoretical foundation for the rational use of DGPPs in clinical practice".
Taken altogether, Dandelion may be considered a remedy for the treatment of blood stasis syndrome (BSS), pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Metabolomics study on promoting blood circulation and ameliorating blood stasis: Investigating the mechanism of Angelica sinensis and its processed products by Yuan Z1, Zhong L1, Hua Y1, Ji P1, Yao W1, Ma Q1, Zhang X1, Wen Y1, Yang L1, Wei Y. (PubMed)
Saturday, February 20, 2021
Herbal Cinnamon in Prevention of Alzheimer's Diseases
Adding spicy cinnamon into your diet may have a significant effect on blocking the onset of Alzheimer's Disease, a new study suggested.
Although cinnamon is best known for its anti-diabetic effect, The spices also consist of certain chemical constituents associated to prevent insulin resistance(2).
The herb has been used in folk medicine as anti-fungal and bacterial agents and to improve the reproductive organ, prevent flatulence and intestinal cramping, treat indigestion, diarrhea, bad breath, headache, migraine, etc.(3).
Alzheimer's disease is a brain disorder correlated with major reductions of neurons to the respective target areas, named after German physician Alois Alzheimer.
Alzheimer's destroys brain cells, causing cognitive modalities severe enough to affect language communication, memory, lifelong hobbies, or social life.
Alzheimer's gets worse over time, and it is fatal.
According to statistics, over 25 million people in the world today are affected by dementia and most are suffering from Alzheimer's disease.
The exact causes of Alzheimer's disease are unknown. However, some researchers suggested that certain risk factors such as cigarette smoking, midlife high blood pressure and obesity, diabetes, and cerebrovascular lesions, and psychosocial factors (high education, active social engagement, physical exercise, and mentally stimulating activity) are associated with the onset of the disease(10).
Some researchers suggested that people who are following lifelong intake of the Western diet and at higher risk due to family history should be aware of some early signs and symptoms such as memory loss, the difficulty of planning and solving problems, completing familiar tasks, determining time or place, finding the right words, misplacing items often. ... and difficulty making decisions.
If you experience some signs and symptoms above, please make sure to check with your doctor to rule out the possibility.
In insulin resistance Winstar male rats induced by high fat/high fructose (HF/HFr), researchers found that injection of cinnamon (CN) alleviates the increases of mRNA associated with Alzheimer's such as PTEN, Tau, and amyloid precursor protein, through its neuroprotective activity associated with improved whole-body insulin sensitivity and related changes in the brain.(4).
Cinnamon aqueous extract also found to have the ability to inhibit tau aggregation in vitro and even induce dissociation of tangles isolated from AD brain, as well as sequestering highly reactive and toxic byproducts of oxidation, through protecting tau from abnormal modifications, according to the University of California(5).
PTEN, is a tumor suppressor gene involved in the regulation of the cell cycle.
Tau protein found in neurons of the central nervous system, un-stabilized microtubules have been found in patients with Alzheimer's Diseases.
Amyloid precursor protein plays an important role in the formation of synapses between neurons in the nervous system, showed to generate beta-amyloid (Aβ) in patients with Alzheimer's diseases
In cognitive impairment in Alzheimer's disease animal models, caused by the accumulation of soluble oligomeric assemblies of the β-amyloid polypeptide (Aβ), oral administration of the cinnamon extract (CEppt), enhanced the decrease of Aβ oligomers, reduction of plaques, and improvement in cognitive behavior(6).
Some researchers suggested that the spice may be used as amyloid-beta aggregation blockers as a few approved drugs available to treat Alzheimer's disease(9) due to many potential drugs in the pipeline for the disease and other amyloid-associated illnesses may not be as promising as thought(8).
Taken altogether, cinnamon and its extract may have a protective effect in reduced risk and for treatment of Alzheimer's Diseases, through reduction of the complication causes by metabolic syndromes such as obesity and diabetes.
According to DR. Georgakopoulou EA(7), Oral intake of Cinnamon may cause Stomatitis and a burning sensation in the mouth with a large amount. According to traditional Chinese medicine, overdoses of cinnamon can be toxic and damaged to the liver(1)(7).
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Cinnamon extract improves insulin sensitivity in the brain and lowers liver fat in mouse models of obesity by Sartorius T1, Peter A2, Schulz N3, Drescher A2, Bergheim I4, Machann J5, Schick F6, Siegel-Axel D2, Schürmann A3, Weigert C1, Häring HU1, Hennige AM(PubMed)
(2) Neurochemical and behavioral effects of Cinnamomi cassiae (Lauraceae) bark aqueous extract in obese rats by Bano F1, Ikram H2, Akhtar N3.(PubMed)
(3) @Popular Herbs -Cinnamon
(4) Cinnamon counteracts the negative effects of a high fat/high fructose diet on behavior, brain insulin signaling and Alzheimer-associated changes by Anderson RA1, Qin B2, Canini F3, Poulet L4, Roussel AM(PubMed)
(5) Interaction of cinnamaldehyde and epicatechin with tau: implications of beneficial effects in modulating Alzheimer's disease pathogenesis by George RC1, Lew J, Graves DJ. (PubMed)
(6) Orally administrated cinnamon extract reduces β-amyloid oligomerization and corrects cognitive impairment in Alzheimer's disease animal models by Frydman-Marom A1, Levin A, Farfara D, Benromano T, Scherzer-Attali R, Peled S, Vassar R, Segal D, Gazit E, Frenkel D, Ovadia M.(PubMed)
(7) Alzheimer's disease drug discovery from herbs: neuroprotectivity from beta-amyloid (1-42) insult by Kim DS1, Kim JY, Han YS. (PubMed)
(8) Amyloid blockers may be a dead end(The scientist)
(9) Simple in vitro assays to identify amyloid-beta aggregation blockers for Alzheimer's disease therapy by Guo JP1, Yu S, McGeer PL. (PubMed)
(10) Alzheimer's disease in Foods Points of View(General health)
Although cinnamon is best known for its anti-diabetic effect, The spices also consist of certain chemical constituents associated to prevent insulin resistance(2).
The herb has been used in folk medicine as anti-fungal and bacterial agents and to improve the reproductive organ, prevent flatulence and intestinal cramping, treat indigestion, diarrhea, bad breath, headache, migraine, etc.(3).
Alzheimer's disease is a brain disorder correlated with major reductions of neurons to the respective target areas, named after German physician Alois Alzheimer.
Alzheimer's destroys brain cells, causing cognitive modalities severe enough to affect language communication, memory, lifelong hobbies, or social life.
Alzheimer's gets worse over time, and it is fatal.
According to statistics, over 25 million people in the world today are affected by dementia and most are suffering from Alzheimer's disease.
The exact causes of Alzheimer's disease are unknown. However, some researchers suggested that certain risk factors such as cigarette smoking, midlife high blood pressure and obesity, diabetes, and cerebrovascular lesions, and psychosocial factors (high education, active social engagement, physical exercise, and mentally stimulating activity) are associated with the onset of the disease(10).
Some researchers suggested that people who are following lifelong intake of the Western diet and at higher risk due to family history should be aware of some early signs and symptoms such as memory loss, the difficulty of planning and solving problems, completing familiar tasks, determining time or place, finding the right words, misplacing items often. ... and difficulty making decisions.
If you experience some signs and symptoms above, please make sure to check with your doctor to rule out the possibility.
In insulin resistance Winstar male rats induced by high fat/high fructose (HF/HFr), researchers found that injection of cinnamon (CN) alleviates the increases of mRNA associated with Alzheimer's such as PTEN, Tau, and amyloid precursor protein, through its neuroprotective activity associated with improved whole-body insulin sensitivity and related changes in the brain.(4).
Cinnamon aqueous extract also found to have the ability to inhibit tau aggregation in vitro and even induce dissociation of tangles isolated from AD brain, as well as sequestering highly reactive and toxic byproducts of oxidation, through protecting tau from abnormal modifications, according to the University of California(5).
PTEN, is a tumor suppressor gene involved in the regulation of the cell cycle.
Tau protein found in neurons of the central nervous system, un-stabilized microtubules have been found in patients with Alzheimer's Diseases.
Amyloid precursor protein plays an important role in the formation of synapses between neurons in the nervous system, showed to generate beta-amyloid (Aβ) in patients with Alzheimer's diseases
In cognitive impairment in Alzheimer's disease animal models, caused by the accumulation of soluble oligomeric assemblies of the β-amyloid polypeptide (Aβ), oral administration of the cinnamon extract (CEppt), enhanced the decrease of Aβ oligomers, reduction of plaques, and improvement in cognitive behavior(6).
Some researchers suggested that the spice may be used as amyloid-beta aggregation blockers as a few approved drugs available to treat Alzheimer's disease(9) due to many potential drugs in the pipeline for the disease and other amyloid-associated illnesses may not be as promising as thought(8).
Taken altogether, cinnamon and its extract may have a protective effect in reduced risk and for treatment of Alzheimer's Diseases, through reduction of the complication causes by metabolic syndromes such as obesity and diabetes.
According to DR. Georgakopoulou EA(7), Oral intake of Cinnamon may cause Stomatitis and a burning sensation in the mouth with a large amount. According to traditional Chinese medicine, overdoses of cinnamon can be toxic and damaged to the liver(1)(7).
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Cinnamon extract improves insulin sensitivity in the brain and lowers liver fat in mouse models of obesity by Sartorius T1, Peter A2, Schulz N3, Drescher A2, Bergheim I4, Machann J5, Schick F6, Siegel-Axel D2, Schürmann A3, Weigert C1, Häring HU1, Hennige AM(PubMed)
(2) Neurochemical and behavioral effects of Cinnamomi cassiae (Lauraceae) bark aqueous extract in obese rats by Bano F1, Ikram H2, Akhtar N3.(PubMed)
(3) @Popular Herbs -Cinnamon
(4) Cinnamon counteracts the negative effects of a high fat/high fructose diet on behavior, brain insulin signaling and Alzheimer-associated changes by Anderson RA1, Qin B2, Canini F3, Poulet L4, Roussel AM(PubMed)
(5) Interaction of cinnamaldehyde and epicatechin with tau: implications of beneficial effects in modulating Alzheimer's disease pathogenesis by George RC1, Lew J, Graves DJ. (PubMed)
(6) Orally administrated cinnamon extract reduces β-amyloid oligomerization and corrects cognitive impairment in Alzheimer's disease animal models by Frydman-Marom A1, Levin A, Farfara D, Benromano T, Scherzer-Attali R, Peled S, Vassar R, Segal D, Gazit E, Frenkel D, Ovadia M.(PubMed)
(7) Alzheimer's disease drug discovery from herbs: neuroprotectivity from beta-amyloid (1-42) insult by Kim DS1, Kim JY, Han YS. (PubMed)
(8) Amyloid blockers may be a dead end(The scientist)
(9) Simple in vitro assays to identify amyloid-beta aggregation blockers for Alzheimer's disease therapy by Guo JP1, Yu S, McGeer PL. (PubMed)
(10) Alzheimer's disease in Foods Points of View(General health)
Cranberry Shows a Potential Effect in Improving the Ratio of Gut Microbiota
Gut microbiota is a complex community with over a trillion microorganisms that lives in our digestive tracts.
According to the ESMN, the microbiota can weigh up to 2 kg, including 1/3 of gut microbiota found in most people, comapred to 2/3 that are specific to individuals depending on geography, environment, and lifestyle.
In healthy individuals, the ratio of good and bad microorganisms is balanced. In other words, healthy gut microbiota levels maintain the structure and function of the gastrointestinal tract.
A balanced ratio of gut microbiota plays a critical role in the digestion of certain foods that the stomach and small intestine have not been able to digest, in the production of vitamins, improvement of digestive functioning, and modulation of the immune function.
The use of antibiotics has been found to damage the gut ecosystem, leading to certain chronic illnesses such as inflammatory bowel disease, obesity, cancer, and autism.
Unhealthy gut microbiota has been found to
* Decrease the interaction with the immune function against inflammatory immune disorders.
* Increase the risk of gastrointestinal diseases and non-gastrointestinal diseases caused by overexpression of bad bacteria.
* Reduce nutrient extraction from the diet, thus increasing the risk of obesity and obesity complications.
* Increase the risk of control brain insulin signaling and metabolite levels that can lead to bad neurobehaviors.
Further, the unbalanced ratio of gut microbiota functions also alters immune homeostasis, leading to the onset of autoimmune disorders which in turn can affect the development of not only intestinal but also systemic autoimmune diseases.
Compared to probiotics, the prebiotics is compound in food that induces the growth or activity of beneficial microorganisms in the gut.
In other definition, it is a special form of dietary fiber that acts as a fertilizer that promotes the growth of good bacteria in your gut.
In the gastrointestinal tract, prebiotics can alter the composition of organisms in the gut microbiome.
In other words, prebiotics raises the levels of healthy bacteria against bad bacteria.
Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.
On finding a potential compound for the promotion of digestive functioning, researchers examined the effect of cranberries' impact on gut microbiota.
The randomized, double-blind, cross-over, controlled design trial included a total of 11 healthy adults consumed for 5 days each a control diet (animal-based diet (meats, dairy products, and simple sugars) plus 30 g/day placebo powder) and a cranberry diet (animal-based diet plus 30 g/day freeze-dried whole cranberry powder).
According to the tested analysis of the stool, urine, and blood samples, compared to the pre-control diet, the control diet modified 46 taxonomic clades in the gut, including an increase in the abundance of Firmicutes and decrease in Bacteroidetes and increased bacteria-derived deoxycholic acid and decreased acetate and butyrate in stool
In other words, the control diet induces a significant change of gut microbiotas by favoring the "bad" organisms.
Comapred to the post control diet, the cranberry diet modified 9 taxonomic clades, including a decrease in the abundance of Firmicutes and an increase in Bacteroidetes in the flavor of the good organisms in the gut.
Furthermore, cranberry promoted the balancing ratio of gut microbiotas by attenuating control diet-induced increase in secondary bile acids and decrease the short-chain fatty acids (SCFA) and increase urinary anthocyanins and bacterially derived phenolic acids.
Based on the findings, researchers said, "an animal-based diet altered the microbiota composition to a less favorable profile, increased carcinogenic bile acids, and decreased beneficial SCFA. Cranberries attenuated the impact of the animal-based diet on microbiota composition, bile acids, and SCFA, evidencing their capacity to modulate the gut microbiota".
Taken altogether, cranberry may be considered a remedy for the promotion of gut health, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cranberries attenuate animal-based diet-induced changes in microbiota composition and functionality: a randomized crossover controlled feeding trial by Rodríguez-Morató J1, Matthan NR2, Liu J3, de la Torre R4, Chen CO. (PubMed)
(2) Impact of Cranberries on Gut Microbiota and Cardiometabolic Health: Proceedings of the Cranberry Health Research Conference 2015 by Blumberg JB1, Basu A2, Krueger CG3, Lila MA4, Neto CC5, Novotny JA6, Reed JD3, Rodriguez-Mateos A7, Toner CD. (PubMed)
(3) The influence of antibiotics and dietary components on gut microbiota by Ruth K. Dudek-Wicher,
Adam Junka, and Marzenna Bartoszewicz. (PMC)
According to the ESMN, the microbiota can weigh up to 2 kg, including 1/3 of gut microbiota found in most people, comapred to 2/3 that are specific to individuals depending on geography, environment, and lifestyle.
In healthy individuals, the ratio of good and bad microorganisms is balanced. In other words, healthy gut microbiota levels maintain the structure and function of the gastrointestinal tract.
A balanced ratio of gut microbiota plays a critical role in the digestion of certain foods that the stomach and small intestine have not been able to digest, in the production of vitamins, improvement of digestive functioning, and modulation of the immune function.
The use of antibiotics has been found to damage the gut ecosystem, leading to certain chronic illnesses such as inflammatory bowel disease, obesity, cancer, and autism.
Unhealthy gut microbiota has been found to
* Decrease the interaction with the immune function against inflammatory immune disorders.
* Increase the risk of gastrointestinal diseases and non-gastrointestinal diseases caused by overexpression of bad bacteria.
* Reduce nutrient extraction from the diet, thus increasing the risk of obesity and obesity complications.
* Increase the risk of control brain insulin signaling and metabolite levels that can lead to bad neurobehaviors.
Further, the unbalanced ratio of gut microbiota functions also alters immune homeostasis, leading to the onset of autoimmune disorders which in turn can affect the development of not only intestinal but also systemic autoimmune diseases.
Compared to probiotics, the prebiotics is compound in food that induces the growth or activity of beneficial microorganisms in the gut.
In other definition, it is a special form of dietary fiber that acts as a fertilizer that promotes the growth of good bacteria in your gut.
In the gastrointestinal tract, prebiotics can alter the composition of organisms in the gut microbiome.
In other words, prebiotics raises the levels of healthy bacteria against bad bacteria.
Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.
On finding a potential compound for the promotion of digestive functioning, researchers examined the effect of cranberries' impact on gut microbiota.
The randomized, double-blind, cross-over, controlled design trial included a total of 11 healthy adults consumed for 5 days each a control diet (animal-based diet (meats, dairy products, and simple sugars) plus 30 g/day placebo powder) and a cranberry diet (animal-based diet plus 30 g/day freeze-dried whole cranberry powder).
According to the tested analysis of the stool, urine, and blood samples, compared to the pre-control diet, the control diet modified 46 taxonomic clades in the gut, including an increase in the abundance of Firmicutes and decrease in Bacteroidetes and increased bacteria-derived deoxycholic acid and decreased acetate and butyrate in stool
In other words, the control diet induces a significant change of gut microbiotas by favoring the "bad" organisms.
Comapred to the post control diet, the cranberry diet modified 9 taxonomic clades, including a decrease in the abundance of Firmicutes and an increase in Bacteroidetes in the flavor of the good organisms in the gut.
Furthermore, cranberry promoted the balancing ratio of gut microbiotas by attenuating control diet-induced increase in secondary bile acids and decrease the short-chain fatty acids (SCFA) and increase urinary anthocyanins and bacterially derived phenolic acids.
Based on the findings, researchers said, "an animal-based diet altered the microbiota composition to a less favorable profile, increased carcinogenic bile acids, and decreased beneficial SCFA. Cranberries attenuated the impact of the animal-based diet on microbiota composition, bile acids, and SCFA, evidencing their capacity to modulate the gut microbiota".
Taken altogether, cranberry may be considered a remedy for the promotion of gut health, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cranberries attenuate animal-based diet-induced changes in microbiota composition and functionality: a randomized crossover controlled feeding trial by Rodríguez-Morató J1, Matthan NR2, Liu J3, de la Torre R4, Chen CO. (PubMed)
(2) Impact of Cranberries on Gut Microbiota and Cardiometabolic Health: Proceedings of the Cranberry Health Research Conference 2015 by Blumberg JB1, Basu A2, Krueger CG3, Lila MA4, Neto CC5, Novotny JA6, Reed JD3, Rodriguez-Mateos A7, Toner CD. (PubMed)
(3) The influence of antibiotics and dietary components on gut microbiota by Ruth K. Dudek-Wicher,
Adam Junka, and Marzenna Bartoszewicz. (PMC)
Friday, February 19, 2021
Angelica Sinensis, the Natural Anticancer Herbal Remedy
Cancer is the class of diseases associated with the growth of the cells disorderly and uncontrollably due to the alternation of DNA.
Most cases of cancer begin in the cells on the surface of the inner lining tissues of the organ or gland. At the early stage, most cancers are asymptomatic.
However, at the advanced stage, most cancers not can induce common symptoms such as gastrointestinal discomforts, unintended weight loss, loss of appetite and fatigue but also localized symptoms depending on the affected tissues and organs.
The American Cancer Society wrote, "Cancer may also cause symptoms like fever, extreme tiredness (fatigue), or weight loss. Because cancer cells use up much of the body’s energy supply, or they may release substances that change the way the body makes energy from food. Cancer can also cause the immune system to react in ways that produce these signs and symptoms" and " Sometimes, cancer cells release substances into the bloodstream that cause symptoms that are not usually linked to cancer".
Cancers at this stage also can travel a distance away from the original site to induce secondary metastasis.
According to the statistics provided by the American cancer society, in 2018,1,735,350 new cases were diagnosed, representing more than 4,700 new cancer diagnoses each day.
The lifetime probability of being diagnosed with cancer is 39.7% for men and 37.6% for women.
Compared to all cancers, lung, breast, prostate, and colorectal cancers are the most common cancer in the US.
The prevalent factors associated with the risk of cancer are age, excessive alcohol drinking, exposure to cancer causing-substances, diseases associated with chronic inflammation, unhealthy diet, hormone therapy, use of immunosuppression.
Cancers are the second leading cause of death worldwide besides heart diseases. Believe or not, 1/4 of cancers death are due to lung cancer.
On finding a natural ingredient for the prevention and treatment of chronic diseases, scientists examined Radix Angelica Sinensis (Danggui in Chinese) is widely used in traditional Chinese medicine (TCM). N-butylidenephthalide (BP), a bioactive compound in Dangui, is a potential antitumor agent for various cancer types.
Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.
The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.
According to the experimental results,* Danggui users were found to have an increased survival rate when compared with Danggui nonusers (log-rank test p = 0.002).
* The use of Danggui highly associated with decreased mortality (the adjusted hazard ratio (HR) of Danggui users was 0.72 [95 % CI, 0.57-0.92] (p = 0.009).
* The in vitro results showed that BP inhibited gastric cancer cell proliferation, and triggered cellular apoptosis depending on the activation of the mitochondrial apoptotic pathway.
* According to the RNA-seq analysis, BP induced an increase of REDD1 expression that inhibits mTOR signaling, thus inhibiting gastric cancer growth.
* BP suppressed the growth of AGS xenograft tumor in vivo.
Based on the results, researchers suggest, "Danggui can prolong the survival rate of gastric cancer patients in Taiwan. BP caused gastric cancer cell death through the activation of mitochondria-intrinsic pathway and induced the REDD1 expression leading to mTOR signal pathway inhibition in gastric cancer cells".
Taken altogether, Dandelion may be considered anti-cancer activity, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Anti-Cancer Effects of Radix Angelica Sinensis (Danggui) and N-Butylidenephthalide on Gastric Cancer: Implications for REDD1 Activation and mTOR Inhibition by Liao KF1,2, Chiu TL3,4, Huang SY5, Hsieh TF3,6, Chang SF7, Ruan JW8, Chen SP9, Pang CY10,11, Chiu SC. (PubMed)
Sunday, February 7, 2021
Cranberry Protects the Liver Against Inflammation
The liver is the largest internal organ located in the upper right portion of the abdomen, beneath your diaphragm, and above your stomach.
The liver not only plays a critical role to filter the blood coming from the intestine before passing them to other parts of the body but also protects our body against toxins by detoxifying chemicals and metabolizes drugs.
Additionally, the liver also inhibits oxidative stress by producing the antioxidant enzyme that counters the expression of free radicals in the body.
Inflammation is a natural response by the immune system to protect the body against the invasion of stimuli or foreign pathogens.
Acute inflammation is a short-term condition caused by tissue injury, leading to pain, redness, swelling, and heat to the affected area. depending on the size of the injury. Some patients with acute inflammation may also experience the symptom of loss of function.
In acute inflammation, the white blood cells on the first line of defense of the immune system after sensing the danger of an infection in the body through a message from the brain stimulate the production of platelets to cover the site of injury or damage and inflammatory cytokines to kill off all pathogens before they can cause harm to the body.
Most cases of infection are stopped at the acute phase. The wound or injury is slowly recovered.
Liver inflammation is a medical condition d with autoimmune hepatitis and hepatitis and medications, drugs, toxins, and alcohol.
Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.
On finding a potential compound for the treatment of liver diseases associated with oxidative stress, researchers compared the effect of a polyphenol-rich cranberry extract (CBE) and high fat-fed obese C57BL/6J mice on hepatic inflammation.
0.8% CBE treatment for 10 weeks showed no change in body weight or visceral fat mass compared to high fat-fed control mice.
However, CBE exerted a significant decrease in plasma alanine aminotransferase (31%) associated with liver stress and histological severity of NAFLD by a 33% decrease in the area and a 29% decrease in lipid droplet size, compared to high fat-fed mice.
Hepatic protein levels of tumor necrosis factor-alpha and C-C chemokine ligand 2, hepatic mRNA levels of toll-like receptor 4 (TLR4,) and nuclear factorκ B (NFκB), associated with the inflammation were also reduced by 28%, 19%, 63%, and 24% and respectively, following CBE supplementation.
Furthermore, the genes related to the inflammasome of the nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3 also were decreased by injection of CBE supplementation.
Based on the findings, researchers said, "CBE reduced... hepatic inflammation in high fat-fed obese C57BL/6J mice"
And "These effects appear to be related to mitigation of TLR4-NFκB related signaling"
Taken altogether, cranberry may be considered a remedy for the treatment and management of liver inflammation, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cranberry extract attenuates hepatic inflammation in high fat-fed obese mice by Shannon L. Glisan,a Caroline Ryan,b Andrew P. Neilson,b and Joshua D. Lambert. (PMC)
The liver not only plays a critical role to filter the blood coming from the intestine before passing them to other parts of the body but also protects our body against toxins by detoxifying chemicals and metabolizes drugs.
Additionally, the liver also inhibits oxidative stress by producing the antioxidant enzyme that counters the expression of free radicals in the body.
Inflammation is a natural response by the immune system to protect the body against the invasion of stimuli or foreign pathogens.
Acute inflammation is a short-term condition caused by tissue injury, leading to pain, redness, swelling, and heat to the affected area. depending on the size of the injury. Some patients with acute inflammation may also experience the symptom of loss of function.
In acute inflammation, the white blood cells on the first line of defense of the immune system after sensing the danger of an infection in the body through a message from the brain stimulate the production of platelets to cover the site of injury or damage and inflammatory cytokines to kill off all pathogens before they can cause harm to the body.
Most cases of infection are stopped at the acute phase. The wound or injury is slowly recovered.
Liver inflammation is a medical condition d with autoimmune hepatitis and hepatitis and medications, drugs, toxins, and alcohol.
Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.
On finding a potential compound for the treatment of liver diseases associated with oxidative stress, researchers compared the effect of a polyphenol-rich cranberry extract (CBE) and high fat-fed obese C57BL/6J mice on hepatic inflammation.
0.8% CBE treatment for 10 weeks showed no change in body weight or visceral fat mass compared to high fat-fed control mice.
However, CBE exerted a significant decrease in plasma alanine aminotransferase (31%) associated with liver stress and histological severity of NAFLD by a 33% decrease in the area and a 29% decrease in lipid droplet size, compared to high fat-fed mice.
Hepatic protein levels of tumor necrosis factor-alpha and C-C chemokine ligand 2, hepatic mRNA levels of toll-like receptor 4 (TLR4,) and nuclear factorκ B (NFκB), associated with the inflammation were also reduced by 28%, 19%, 63%, and 24% and respectively, following CBE supplementation.
Furthermore, the genes related to the inflammasome of the nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3 also were decreased by injection of CBE supplementation.
Based on the findings, researchers said, "CBE reduced... hepatic inflammation in high fat-fed obese C57BL/6J mice"
And "These effects appear to be related to mitigation of TLR4-NFκB related signaling"
Taken altogether, cranberry may be considered a remedy for the treatment and management of liver inflammation, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cranberry extract attenuates hepatic inflammation in high fat-fed obese mice by Shannon L. Glisan,a Caroline Ryan,b Andrew P. Neilson,b and Joshua D. Lambert. (PMC)
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