Fennel may have a potential and positive effect in modulated the effect of chemo drugs through its chemomodulatory activity, some scientists suggested.
The expression of fennel application in enhanced chemopreventive response was evident in animal models from the reduced tumor burden in reduced cancer cells proliferation and apoptosis and reduced percentage of tumor through some different publications.
The results were reported by several respectable institute including Jawaharlal Nehru University and published on online medical literature.
Fennel (Foeniculum vulgare) is a plant species of the genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean, used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...
Nutrients
1. Carbohydrates
2. Fiber
3. Protein
4. Thiamine (Vitamin B1)
5. Riboflavin (Vitamin B2)
6. Niacin (Vitamin B3)
7. Pantothenic acid (B5)
8. Vitamin B6
9. Folate (Vitamin B9)
10. Vitamin C
11. Calcium
12. Copper
13. Iron
14. Magnesium
15. Molybdenum
16. Phosphorus
17. Potassium
18. Zinc
According to the Jawaharlal Nehru University, in evaluating the chemopreventive effect of different doses of test diet of Foeniculum vulgare Mill (Fennel) seeds on DMBA-induced skin and B(a)P-induced forestomach papilloma genesis in Swiss albino mice, application of fennel seeds displayed a significant reduction in the skin and the forestomach tumor incidence and tumor multiplicity as compared to the control group.
Biochemical assays showed a significant increase in the content/activities of phase I and II enzymes especially in the case of a 6% test diet, in detoxifying poisonous compounds caused by the injection of DMBA, through significant enhancement of antioxidant activities.
Further examination also found that injection of fennel seed stimulated production of antioxidant enzyme in the body tissue in repaired damage precipitated by peroxidation through lactate dehydrogenase activity.
Dr. Singh B, the lead author said, "A significant enhancement in the activities of antioxidant enzymes were observed especially at 4% and 6%" and "glyoxalase I(with function as an enzymatic defense against glycation) activity and the content of reduced glutathione (antioxidant) were significantly elevated".
Additionally, in the examine the effect of fennel bioactive compound anethole in chemo modulatory activity against the onset and spread of cancer, researchers found that application of fennel oil by inhibited the activated expression of NF-kappa B, a gene-altering and inflammation in triggering molecule in the development of various solid tumors through stimulated cancer proliferation.
Also, anethole injection reduced levels of tumor necrosis factor (TNF, tumor necrosis factor-alpha, TNFα, cachexin, or cachectin), a cell-signaling protein (cytokine) involved in systemic inflammation and one of the cytokines that make up the acute phase reaction. However, at a certain stage of cancer, gene expression in promoted cancer apoptosis is alternated, TNF changes from a cancer killer to a cancer promoter.
Additionally, with abundant fiber, fennel demonstrated a strong effect in the removal of toxins from the colon and therefore may be helpful in colon cancer prevention.
Dr. After taking into account other co and confounders said, " Fennel contains flavonoid anti-oxidants compounds like kaempferol and quercetin which helps eliminate harmful free radicals from the body....".
In other words, fennel exerted chemo modulatory activity also through its flavonoid anti-oxidants compounds like kaempferol and quercetin in inhibited overexpression of free radicals and free radical chain reactive in protected against cytotoxicity in induction cells damage and alternated cell DNA in the facilitated onset of cancer.
Taking all together, fennel and its bioactive compound may be considered as a chemopreventive and modulatory functional food for reduced risk and treatment of various types of cancers.
For More information on yoga lessons tailor to a complete well being for women, please visit: YOGA FOR WOMEN
Natural Medicine for Fatty Liver And Obesity Reversal
Use The Revolutionary Findings To Achieve Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) Chemomodulatory action of Foeniculum vulgare (Fennel) on skin and forestomach papillomagenesis, enzymes associated with xenobiotic metabolism and antioxidant status in murine model system by Singh B1, Kale RK(PubMed)
(2) Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology by Shamkant B. Badgujar,* Vainav V. Patel, and Atmaram H. Bandivdekar(PubMed)
(3) Arzoo and Milind Parle, Pharmacology Division, Department of Pharm. Sciences, Guru Jambheshwar University of Science and Technology(EUROPEAN JOURNAL OF PHARMACEUTICALAND MEDICAL RESEARCH)
Wednesday, July 14, 2021
Friday, July 9, 2021
Herbal Turmeric Protects the Kidneys Against Drugs, Heavy Metals and Substances Toxicity
The kidneys are a pair of kidney shape organs located on either side of your spine with a function to filter out the wastes from the blood before passing the wastes through urinary secretion.
More than a detoxed organ, the kidneys also maintain the body fluid balance, regulate the production of red blood cells and high blood pressure.
Kidney damage can be acute such as an overdose of toxin or chronic. Acute kidney diseases can be cured if the underlying cause is found.
Chronic kidney disease (CKD) is a slow and progressive disease that can lead to kidney failure over time.
The advance of CKD can cause dangerous levels of fluid, electrolytes, and waste build-up in the body.
According to statistics, approximately 14 percent of the US general population suffers from CKD. Believe it or not, more than 661,000 Americans have kidney failure. Of these, 468,000 individuals are on dialysis, and roughly 193,000 live with a functioning kidney transplant.
Out of many risk factors associated with CKD, some researchers suggested high blood pressure is one most prevalent risk factors found in most patients.
The Natural Kidney Foundation wrote, "More than half the people with chronic kidney disease (CKD) have high blood pressure. High blood pressure increases the chance that kidney disease will get worse"
And "Following your treatment plan carefully and keeping your blood pressure under control can help to prevent these complications".
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
On finding a potential compound with the kidney protective property, researchers investigated curcumin, a major phenolic compound the rhizome of the Curcuma species anti kidney toxicity.
In glucose, tartrazine, induced toxicity, curcumin protected the kidney against DNA damage in leucocytes.
In a streptozotocin-induced diabetes rat model, curcumin protected the kidney against overexpression of free radical to cause kidney cell damage through its antioxidant activity.
In the long-term heavy metal model, curcumin inhibited the toxic effect caused by the accumulation of the metal in the induction of kidney cell damage.
In an animal model induced cisplatin-induced acute kidney injury by injection cisplatin, curcumin enhanced the function of cisplatin-resistant cancer cells and decrease its unwanted side effects.
More interestingly, curcumin inhibited the nicotine receptors on kidney cells that link nicotine to accelerated kidney damage in cigarette smokers
In other words. if the kidneys are less able to excrete nicotine, in long term, accumulated extracellular fluid and blood volumes increase, which can lead to severe kidney damage.
In other studies, kidney damage caused maleate, malathion, nicotine, cisplatin, gentamicin, and methotrexate also reversed by the injection of curcumin, similar to those of the aforementioned substances.
Taken altogether, turmeric and its bioactive compound curcumin may be considered remedies for the prevention and treatment of kidney damage, pending the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Protective effects of ginger-turmeric rhizomes mixture on joint inflammation, atherogenesis, kidney dysfunction and other complications in a rat model of human rheumatoid arthritis by Ramadan G1, El-Menshawy O. (PubMed)
(2) Protective effects of curcumin against toxic agents-induced renal failure: a review by Farkhondeh T1, Samarghandian S2, Azimi-Nezhad M2, Shahri AMP. (PubMed)
(3) High Blood Pressure and Chronic Kidney Disease by The Natural Kidney Foundation
More than a detoxed organ, the kidneys also maintain the body fluid balance, regulate the production of red blood cells and high blood pressure.
Kidney damage can be acute such as an overdose of toxin or chronic. Acute kidney diseases can be cured if the underlying cause is found.
Chronic kidney disease (CKD) is a slow and progressive disease that can lead to kidney failure over time.
The advance of CKD can cause dangerous levels of fluid, electrolytes, and waste build-up in the body.
According to statistics, approximately 14 percent of the US general population suffers from CKD. Believe it or not, more than 661,000 Americans have kidney failure. Of these, 468,000 individuals are on dialysis, and roughly 193,000 live with a functioning kidney transplant.
Out of many risk factors associated with CKD, some researchers suggested high blood pressure is one most prevalent risk factors found in most patients.
The Natural Kidney Foundation wrote, "More than half the people with chronic kidney disease (CKD) have high blood pressure. High blood pressure increases the chance that kidney disease will get worse"
And "Following your treatment plan carefully and keeping your blood pressure under control can help to prevent these complications".
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
On finding a potential compound with the kidney protective property, researchers investigated curcumin, a major phenolic compound the rhizome of the Curcuma species anti kidney toxicity.
In glucose, tartrazine, induced toxicity, curcumin protected the kidney against DNA damage in leucocytes.
In a streptozotocin-induced diabetes rat model, curcumin protected the kidney against overexpression of free radical to cause kidney cell damage through its antioxidant activity.
In the long-term heavy metal model, curcumin inhibited the toxic effect caused by the accumulation of the metal in the induction of kidney cell damage.
In an animal model induced cisplatin-induced acute kidney injury by injection cisplatin, curcumin enhanced the function of cisplatin-resistant cancer cells and decrease its unwanted side effects.
More interestingly, curcumin inhibited the nicotine receptors on kidney cells that link nicotine to accelerated kidney damage in cigarette smokers
In other words. if the kidneys are less able to excrete nicotine, in long term, accumulated extracellular fluid and blood volumes increase, which can lead to severe kidney damage.
In other studies, kidney damage caused maleate, malathion, nicotine, cisplatin, gentamicin, and methotrexate also reversed by the injection of curcumin, similar to those of the aforementioned substances.
Taken altogether, turmeric and its bioactive compound curcumin may be considered remedies for the prevention and treatment of kidney damage, pending the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Protective effects of ginger-turmeric rhizomes mixture on joint inflammation, atherogenesis, kidney dysfunction and other complications in a rat model of human rheumatoid arthritis by Ramadan G1, El-Menshawy O. (PubMed)
(2) Protective effects of curcumin against toxic agents-induced renal failure: a review by Farkhondeh T1, Samarghandian S2, Azimi-Nezhad M2, Shahri AMP. (PubMed)
(3) High Blood Pressure and Chronic Kidney Disease by The Natural Kidney Foundation
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