Platelets are tiny blood cells that prevent injury and infection by forming clots to stop bleeding.
Antiplatelet activity is an action that prevents and treats blood clots.
Anticoagulants, commonly known as blood thinners, are conventional medicines used to reduce the coagulation of blood, prolong the clotting time.
Anticoagulants have been used widely for people with a high risk of heart diseases and stroke due to narrowing arteries associated with plaque accumulation on the arterial walls.
Platelets are made in the bone marrow that also produces white and red blood cells.
Diseases associated with low and abnormal blood platelet include
* Thrombocytopenia is a condition characterized by low blood platelet due to abnormal function of the bone marrow that makes platelets. patients with thrombocytopenia due to the low quantity of blood platelets may experience symptoms of a bruise, internal bleeding, nosebleed.
Long-term untreated thrombocytopenia has been found to increase the risk of cancer, liver disease, pregnancy, infections, and an abnormal immune system.
* Essential thrombocythemia is a disease associated with overproducing blood platelets by the bone marrow, leading to symptoms of blood clots that form and block the blood supply to the brain or the heart.
* Secondary thrombocytosis is also another condition caused by too many platelets produced by the bone marrow.
Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.
The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.
On finding a natural compound for the treatment of platelet aggression, the researchers examined the impact of these four commonly used Chinese medicinal herbs on the pharmacokinetics and pharmacodynamics of the combination therapy with clopidogrel and aspirin.
In order to mimic the standard dosing regimen for dual antiplatelet therapy (DAPT) in humans, Sprague-Dawley rats treatment groups were received a bolus oral dose of DAPT on day 1 followed by DAPT for consecutive 13 days in the absence and presence of orally co-administered four TCM herbs (Danshen, Gegen, Danggui, and Chuanxiong) at their low and high doses.
According to the results on day 14, and observed the plasma concentrations of aspirin (ASA) and clopidogrel (CLP) and their corresponding metabolites,
* Co-administration of Gegen and Danggui significantly altered the pharmacokinetics of ASA and CLP in DAPT with increased systemic exposure of ASA and CLP respectively.
Furthermore, DAPT with Danshen, Gegen, and Danggui co-treatment. significant inhibition on rCyp2c11 that enzymes mediate metabolism of ASA and carboxylesterase activities in drug metabolism, compared to a minimal impact on aspirin esterase activity in all co-administered herbs.
Moreover. all DAPT treatment groups showed a significantly longer prothrombin time (PT) compared to a decrease of the DAPT group in presence of Gegen, Danggui, and Chuanxiong with no change to other coagulative expressions.
Taken altogether, Herbal Angelica used combined with other herbal medicine may be used as a remedy to offset the anticoagulant activity of DAPT, pending to larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Impact of the Chinese herbal medicines on dual antiplatelet therapy with clopidogrel and aspirin: Pharmacokinetics and pharmacodynamics outcomes and related mechanisms in rats by Xiao M1, Qian C2, Luo X3, Yang M4, Zhang Y5, Wu C6, Mok C7, Lee P8, Zuo Z. (PubMed)
Friday, December 24, 2021
Sunday, December 19, 2021
Cranberry Inhibits Neurodegenerative Diseases in Vitro
Age-related neurological disorders or neurodegenerative diseases are the conditions of the progressive death of neuron due to aging, leading to the problems with movement (called ataxias), or mental functioning including Alzheimer's disease (AD) and dementia.
Dementia is a general term of neurodegenerative disease that causes a decline in memory and thinking skills severe enough to reduce a person's ability to perform everyday activities and quality of life.
About 5-8% of all people over the age of 65 have some forms of dementia, and this number doubles every five years above that age.
Most common types of dementia are
* Alzheimer's disease
Alzheimer's destroys brain cells, causing problems with memory, thinking, and behavior severe enough to affect language communication, memory, lifelong hobbies or social life. Alzheimer's gets worse over time, and it is fatal.
Over 1 million people in the US alone are currently afflicted by Alzheimer's disease because of degeneration of hippocampus and cerebral cortex(3) of the brain where memory, language, and cognition are located.
* Absence of acetylcholine
Absence of acetylcholine is a condition caused by damage of nerves located in front of the brain, that lead to language difficulty, memory loss, concentration problem, and reduced mobile skills due to lacking reaction in muscular activity and refection and anxiety- and depression-like behaviors.
3. Dementia due to long-term alcohol abuse
Most classic form of the condition is the Korsakoff's dementia results in extremely poor short term memory often associated with the memory losses of confabulations due to diminished processing resources and/or an encoding or retrieval deficit.
* Dementia associated with Parkinson's disease
Parkinson disease (PD) is a disabling, progressive condition that causes cognitive deficit due to the interruption of frontal-subcortical loops that facilitate cognition and parallel the motor loop, and the loss of substantia nigra pars compacta (SNc) dopamine (DA) neurons.
Besides aging, geographical, hereditary and viral, and toxicological exposure may also correlate to the development of the diseases in the elderly.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
In the course of continued finding a natural ingredient for the treatment of age-related neurological disorders (ANDs), researchers examined the effects of ginger used in traditional medicine for the treatment of various disease symptoms.
Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.
On finding a potential compound for the treatment of neurodegenerative diseases, researchers examined the effect of purified cranberry proanthocyanidins (PAC-1A) on neuroblastoma (NB) cell lines.
On SMS-KCNR cells, PAC-1A caused a loss of proton motive force associated with the increase of generation of reactive oxygen species (ROS) that induce cytotoxicity in the tested cell line.
Furthermore, PAC-1A inhibited neuroblastoma (NB) cells proliferation by reducing the expression of the proteins associated with pro-survivals (Bcl-2, MCL-1, Bcl-xL) and increased levels of proteins associated with pro-apoptosis (Bax, Bad, Bid).
Moreover, pathways involved in apoptosis were also increased by the injection of PAC-1A compared to the inhibition of the expression of pathways involved in the promotion of cell cycle division.
More importantly, cyclophosphamide (CP), the chemo drug used to suppress the immune system function also exhibited by the injection of PAC-1A.
In other words, PAC-1A and CP worked synergistically to increase cytotoxicity and expression of pro-apoptotic markers, reduce cellular antioxidants enzymes (glutathione (GSH) and superoxide dismutase (SOD)) levels.
Additional analysis of the anti-cancer activity of PAC-1A, researchers found that Additional features of PAC-1A also slow down the cancer cell cycle progression and induce cell death via TNF-family death receptor activity.
Based on the findings, researchers said, "PAC-1A has demonstrated the chemotherapeutic potential to treat a broad spectrum of NBs including highly malignant tumors that show resistance to standard chemotherapeutics and apoptotic stimuli".
Taken altogether, cranberry may be considered a remedy for the prevention and treatment of neurodegenerative disease, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Purified cranberry proanthocyanidines (PAC-1A) cause pro-apoptotic signaling, ROS generation, cyclophosphamide retention and cytotoxicity in high-risk neuroblastoma cells by Singh AP1, Lange TS, Kim KK, Brard L, Horan T, Moore RG, Vorsa N, Singh RK. (PubMed)
(1) Regulation of redox status in neuronal SH-SY5Y cells by blueberry (Vacciniummyrtillus L.) juice, cranberry (Vaccinium macrocarpon A.) juice and cyanidin by Cásedas G1, González-Burgos E2, Smith C3, López V4, Gómez-Serranillos MP. (PubMed)
(2) Most common diseases of 50 plus - Diseases of Central Nervous system - Dementia: The Types by Kyle J. Norton
Tuesday, December 7, 2021
Cranberry Protects the Integrity of Bladder Cells Against Bladder Cancer
The bladder formed part of the secretory system is a muscular sac in the pelvis, just above and behind the pubic bone.
The bladder has 2 main functions that store the urine made in the kidneys and control urinary secretion.
Cancer is a group of chronic diseases characterized by cell growth disorderly that starts on the surface of the inner lining tissue of a specific tissue of a gland or organ.
Bladder cancer is the most common type of cancer that affects men twice as frequently as it affects women, Bladder cancer usually starts from the cells on the surface of inner tissue that the lines the bladder.
Bladder cancer depending on the origination of cancer beginning can be classified into
* Transitional cell carcinoma
In the early stage of bladder cancer, normal cells become cancerous in the innermost tissue layer of the bladder which can change shape and stretch without breaking apart. In other words, cancer in this stage is able to stretch when the bladder is full and shrink when the bladder is emptied.
More than 90 percent of bladder cancers begin in the transitional cells
* Squamous cell carcinoma
Cancer begins in squamous cells found in the tissues of the surface of the bladder, due to long-term infection or irritation. About 8 percent of people with bladder cancers begin squamous cells.
* Adenocarcinoma
Cancer originates from the glandular tissue of the bladder, including the surface layer of skin, glands, and a variety of other tissue, due to long-term irritation and inflammation. Only 2 percent of people with the condition have a third bladder cancer type.
The exact causes of bladder cancer are unidentified. However, smoking has been associated with a significant factor that causes the onset of the disease.
Dr. Neal D Freedman, the lead scientist wrote, "Previous studies indicate that the population attributable risk of bladder cancer for tobacco smoking is 50–65% in men and 20–30% in women and that current cigarette smoking triples bladder cancer risk relative to never smoking".
And, "Over the last 30 years, incidence rates have remained stable in the United States (men: 123.8/100,000 person-years to 142.2/100,000 person-years; women: 32.5/100,000 person-years to 33.2/100,000 person-years)".
Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.
On finding a potential compound for the treatment of bladder cancer, researchers examined the anti-proliferative activities of cranberry-derived flavonoids on human bladder tumor cell lines (RT4, SCABER, and SW-780) and non-tumorigenic immortalized human uroepithelial cells (SV-HUC).
According to the tested analysis,
* Quercetin 3-O-glucoside, isorhamnetin (3'-O-methyl quercetin), myricetin and quercetin found in cranberry showed strong concentration-dependent cell growth inhibitory activities in bladder cancer cells with IC50 values in a range of 8-92 μM compared to others.
* Isorhamnetin and myricetin had very low inhibitory activity against SV-HUC even at very high concentrations (>200 μM) compared to bladder cancer cells.
These results strongly suggested that isorhamnetin and myricetin inhibited bladder cancer cells without causing harm to the nearby healthy cells.
Furthermore, according to the results of SW-780 cells incubated with the aforementioned compounds, hyperoside, a member of 3-O-galactoside of quercetin undergoes relatively less metabolic biotransformation (methylation, glucuronidation and quinone formation) compared to quercetin 3-O-glucoside.
Based on the findings, researchers said, "isorhamnetin and quercetin 3-O-glucoside may be the active forms of quercetin in the prevention of bladder cancer".
Taken altogether, cranberry processed abundantly bioactive compounds may be considered a remedy for the prevention and treatment of bladder cancer pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Metabolism and growth inhibitory activity of cranberry derived flavonoids in bladder cancer cells by Prasain JK1, Rajbhandari R1, Keeton AB2, Piazza GA2, Barnes S. (PubMed)
(2) Cranberries and Cancer: An Update of Preclinical Studies Evaluating the CancerInhibitory Potential of Cranberry and Cranberry Derived Constituents by Weh KM1, Clarke J2,3,4, Kresty LA. (PubMed)
(3) Association between smoking and risk of bladder cancer among men and women by Neal D Freedman, PhD, MPH,1 Debra T Silverman, ScD, ScM,1 Albert R Hollenbeck, PhD,2Arthur Schatzkin, MD, DrPH,1 and Christian C Abnet, PhD, MPH. (PMC)
The bladder has 2 main functions that store the urine made in the kidneys and control urinary secretion.
Cancer is a group of chronic diseases characterized by cell growth disorderly that starts on the surface of the inner lining tissue of a specific tissue of a gland or organ.
Bladder cancer is the most common type of cancer that affects men twice as frequently as it affects women, Bladder cancer usually starts from the cells on the surface of inner tissue that the lines the bladder.
Bladder cancer depending on the origination of cancer beginning can be classified into
* Transitional cell carcinoma
In the early stage of bladder cancer, normal cells become cancerous in the innermost tissue layer of the bladder which can change shape and stretch without breaking apart. In other words, cancer in this stage is able to stretch when the bladder is full and shrink when the bladder is emptied.
More than 90 percent of bladder cancers begin in the transitional cells
* Squamous cell carcinoma
Cancer begins in squamous cells found in the tissues of the surface of the bladder, due to long-term infection or irritation. About 8 percent of people with bladder cancers begin squamous cells.
* Adenocarcinoma
Cancer originates from the glandular tissue of the bladder, including the surface layer of skin, glands, and a variety of other tissue, due to long-term irritation and inflammation. Only 2 percent of people with the condition have a third bladder cancer type.
The exact causes of bladder cancer are unidentified. However, smoking has been associated with a significant factor that causes the onset of the disease.
Dr. Neal D Freedman, the lead scientist wrote, "Previous studies indicate that the population attributable risk of bladder cancer for tobacco smoking is 50–65% in men and 20–30% in women and that current cigarette smoking triples bladder cancer risk relative to never smoking".
And, "Over the last 30 years, incidence rates have remained stable in the United States (men: 123.8/100,000 person-years to 142.2/100,000 person-years; women: 32.5/100,000 person-years to 33.2/100,000 person-years)".
Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.
On finding a potential compound for the treatment of bladder cancer, researchers examined the anti-proliferative activities of cranberry-derived flavonoids on human bladder tumor cell lines (RT4, SCABER, and SW-780) and non-tumorigenic immortalized human uroepithelial cells (SV-HUC).
According to the tested analysis,
* Quercetin 3-O-glucoside, isorhamnetin (3'-O-methyl quercetin), myricetin and quercetin found in cranberry showed strong concentration-dependent cell growth inhibitory activities in bladder cancer cells with IC50 values in a range of 8-92 μM compared to others.
* Isorhamnetin and myricetin had very low inhibitory activity against SV-HUC even at very high concentrations (>200 μM) compared to bladder cancer cells.
These results strongly suggested that isorhamnetin and myricetin inhibited bladder cancer cells without causing harm to the nearby healthy cells.
Furthermore, according to the results of SW-780 cells incubated with the aforementioned compounds, hyperoside, a member of 3-O-galactoside of quercetin undergoes relatively less metabolic biotransformation (methylation, glucuronidation and quinone formation) compared to quercetin 3-O-glucoside.
Based on the findings, researchers said, "isorhamnetin and quercetin 3-O-glucoside may be the active forms of quercetin in the prevention of bladder cancer".
Taken altogether, cranberry processed abundantly bioactive compounds may be considered a remedy for the prevention and treatment of bladder cancer pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Metabolism and growth inhibitory activity of cranberry derived flavonoids in bladder cancer cells by Prasain JK1, Rajbhandari R1, Keeton AB2, Piazza GA2, Barnes S. (PubMed)
(2) Cranberries and Cancer: An Update of Preclinical Studies Evaluating the CancerInhibitory Potential of Cranberry and Cranberry Derived Constituents by Weh KM1, Clarke J2,3,4, Kresty LA. (PubMed)
(3) Association between smoking and risk of bladder cancer among men and women by Neal D Freedman, PhD, MPH,1 Debra T Silverman, ScD, ScM,1 Albert R Hollenbeck, PhD,2Arthur Schatzkin, MD, DrPH,1 and Christian C Abnet, PhD, MPH. (PMC)
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