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By Kyle J. Norton Health article writer and researcher; Over 10.000
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Some articles have been used as references in medical research, such as
international journal Pharma and Bio science, ISSN 0975-6299.
Diseases of Central Nervous system
Dementia
About 5-8% of all people over the age of 65 have some form of dementia,
and this number doubles every five years above that age. Dementia is the
loss of mental ability, severe enough to interfere with people's every
life and Alzheimer's disease is the most common type of dementia in
aging people.
V. Treatments
C. In traditional Chinese Medicine Perspective(*)
Based on Chinese ancient medical records. causes of dementia are the results of (*)
C.3. Deficiency of Qi, mainly due to
B.3.3. Spleen Qi deficiency
Spleen is a vital organ, according to traditional Chinese medicine with
function in absorbing nutrients and transport them to body's organs and
cells. Spleen Qi deficiency is a condition of the inability of the
spleen in maximized transportation of nutrients to body organs,
including the brain. Prolong period of malnutrition of brain cells may
induce abnormal functions in information transmitting or death of
neurons, causing cognitive impairment(844), including learning and
memory deficits(842) and changes in brain tissues and behavior
patterns(843)(842).
Herbal medicine for Spleen Qi deficiency
4. Cinnamon bark (Rou gui)
Rou gui, an acrid, sweet, very hot herb, is also known as Cinnamon bark, used in TCM as anti-spasmodic(1110), antibiotic(1111), antigastric ulcers(1112), anti impotent and
anti diabetic(1113)(1114) agent and to treat hepatitis(1115),
flatulence(1116), weak digestion(1116), pain in solar plexus(1110),
breast cancer(1117)(1118), tuberculosis(1119)(1120), etc., as it drains
the liver heat, eliminates Qi accumulation, disperses nodules, reduces
stagnation, etc.by enhancing the functions of heart, lung, bladder
channels(1121).
Ingredients
1. Cinnamic aldehyde
2. Cinnamyl acetate
3. Eugenol
4. Aldehyde
5. Pinene
6. Coumarin
7. Cinnamyl alcohol
8. Cinnamic acid
9. Cinnzeylanol
10. Cinnzeylanine
11. Etc.
Cinnamon bark (Rou gui) used in the treatment of symptoms of neurological impairment(1108)(1109)
in traditional Chinese medicine, may be due to its effectiveness of
phytochemicals, including major constituent cinnamaldehyde (CA) and epicatechin (EC)(1122) in exertion of its
neuroprotective effects(1123)(1123), through anti oxidative
stress(1125), anti inflammatory(1124)) activities, against β-amyloid (Aβ) accumulation(1126) induced neurotoxicity causes of Alzheimer's disease.(1126)(1127) and neurodegeneration(1128).
4.1. In Alzheimer's disease
Cinnamon, a multifaceted medicinal plant have shown to consist activities against neurological disorders, including Alzheimer's diseases(1129) by blocking and reversing tau modification and aggregation(1131)(1130)
and ischemic stroke induced cell swelling(1130). In β-amyloid
polypeptide (Aβ), associated to the development of Alzheimer's
disease(AD), in mouses model, oral administration of cinnamon
extract exhibited neuroroprotective effects in enhancing the fully
recover of locomotion defects and totally abolished tetrameric species
of Aβ in their brain(1132). In a high fat/high fructose diet induced
Alzheimer's disease(AD) symptoms, cinnamon
(CN) ameliorated enzyme phosphatase and proteins tensin homolog (PTEN),
tau and amyloid precursor, associated to Alzheimer's disease(AD),
through improved insulin sensitivity and related changes in the
brain(1133).
According to The Business and Technology Center, West Lafayette, Chinese cinnamon, is one of the tested herb with potential for prevention and treatment of early onset of Alzheimer's disease(AD)(1134).
4.2. In Parkinson's disease
In a mice model, oral administration of cinnamon (Cinnamonum verum)
powder upregulaed and/or maintained the level of Parkin/DJ-1, a
beneficial proteins associated to degeneration progression of
Parkinson's disease(1135). through protection of dopaminergic
neurons(1136). In oligomeriztion of α-synuclein (α-syn) formation
associated with the symptoms of Parkinson's Disease, cinnamon extract
precipitation (CEppt), inhibited oligomeric and fibrillar forms of α-syn
through ameliorated aggregation of β-amyloid polypeptide(1137).
4.3. In neuroprotective effects
Oxidative stress has shown to associate to brain damage due to its high consumption of oxygen.
Cinnamon polyphenols, during oxidative stress, exhibited neuroprotective
effects in glial cells by reduced overexpression of the proinflammatory
factors(1138) and enhanced prosurvival proteins protein levels (sirtuin
1, 2, and 3, deacetylases) associated to glioma cells survival(1139).
Cinnamaldehyde, a major chemical found in cinnamon,
inhibited uncontrolled activation of microglia contributing to
neuroinflammation involved in the development of neurodegenerative
diseases(1140). The herbal water extract, also exerted neuro protective
effect against glutamate-induced neuronal death through the inhibition
of Ca(2+) influx(1141).
Reprinted from Norton Journal, Volume
I, Most Common Diseases of Ages of 50 Plus - Chapter of Diseases of
Central Nervous system(CNS): Dementia - Treatments in Traditional
Chinese Herbal Medicine by Kyle J. Norton
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
References
(*) http://www.hindawi.com/journals/ecam/2012/692621/
(842) http://www.ncbi.nlm.nih.gov/pubmed/25313575
(843) http://www.ncbi.nlm.nih.gov/pubmed/24224039
(844) http://www.ncbi.nlm.nih.gov/pubmed/23391905
(1108) http://www.ncbi.nlm.nih.gov/pubmed/24358170
(1109) http://www.ncbi.nlm.nih.gov/pubmed/23475543
(1110) http://www.ncbi.nlm.nih.gov/pubmed/?term=cinnamon+anti-spasmodic
(1111) http://www.ncbi.nlm.nih.gov/pubmed/24885682
(1112) http://www.ncbi.nlm.nih.gov/pubmed/22760889
(1113) http://www.ncbi.nlm.nih.gov/pubmed/25392573
(1114) http://www.ncbi.nlm.nih.gov/pubmed/25051315
(1115) http://www.ncbi.nlm.nih.gov/pubmed/24337968
(1116) http://www.ncbi.nlm.nih.gov/pubmed/23868387
(1117) http://www.ncbi.nlm.nih.gov/pubmed/25268975
(1118) http://www.ncbi.nlm.nih.gov/pubmed/19969552
(1119) http://www.ncbi.nlm.nih.gov/pubmed/22512578
(1120) http://www.ncbi.nlm.nih.gov/pubmed/23607932
(1121) http://alternativehealing.org/gui_zhi.htm
(1122) http://www.ncbi.nlm.nih.gov/pubmed/23531502
(1123) http://www.ncbi.nlm.nih.gov/pubmed/21360003
(1124) http://www.ncbi.nlm.nih.gov/pubmed/23497886
(1125) http://www.ncbi.nlm.nih.gov/pubmed/25301673
(1126) http://www.ncbi.nlm.nih.gov/pubmed/21305046
(1127) http://www.ncbi.nlm.nih.gov/pubmed/20061605
(1128) http://www.ncbi.nlm.nih.gov/pubmed/15229712
(1129) http://www.ncbi.nlm.nih.gov/pubmed/24817901
(1130) http://www.ncbi.nlm.nih.gov/pubmed/20513336
(1131) http://www.ncbi.nlm.nih.gov/pubmed/19433898
(1132) http://www.ncbi.nlm.nih.gov/pubmed/21305046
(1133) http://www.ncbi.nlm.nih.gov/pubmed/24349472
(1134) http://www.ncbi.nlm.nih.gov/pubmed/17480132
(1135) http://www.ncbi.nlm.nih.gov/pubmed/24946862
(1136) http://www.ncbi.nlm.nih.gov/pubmed/25284437
(1137) http://www.ncbi.nlm.nih.gov/pubmed/22575665
(1138) http://www.ncbi.nlm.nih.gov/pubmed/24631135
(1139) http://www.ncbi.nlm.nih.gov/pubmed/24239092
(1140) http://www.ncbi.nlm.nih.gov/pubmed/23497886
(1141) http://www.ncbi.nlm.nih.gov/pubmed/10960905
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