Antioxidants are stable atoms produced either by the host body or intake of dietary antioxidants rich food with the function that inhibits oxidation caused by free radicals.
Free radicals are highly reactive molecules with an unpaired electron on the outer ring of the atom.
Due to its nature to become stable, free radicals readily to donate or steal an electron from other molecules, leading to the chain of domino's effect that can not be stopped until either the electrons are paired or inhibited by antioxidants.
This chain of reaction is the cause of oxidative stress, a condition is associated with either overexpression of free radicals or depletion of antioxidant enzymes produced by the host organs.
Overexpression of free radicals is known to cause damage in contributing to the etiology of many chronic health problems such as cardiovascular and inflammatory disease, cataracts, and cancer by inducing the alternation of lipids, proteins, and cell DNA damage.
Colon cancer is relatively very common and slowly growing and progressing in a predictable way.
Most cases of primary colon cancer start in the cell on the surface of the inner lining of the colon. At the early stage. most patients with colon cancer do not experience any symptoms.
However, at the advanced stage, the tumor not only can spread to other healthy tissue and organs a distance away through blood and fluid circulation but also suppress the nearby tissue and nerve cells.
The progression of colon cancer at this stage not only induces symptoms of the change in bowel habits, the change in the consistency of your stool, that lasts longer than four weeks but also causes rectal bleeding and persistent abdominal severe pain.
According to the statistic by the American Cancer Society, in the US, there are
97,220 new cases of colon cancer were diagnosed in 2018. The lifetime risk of developing colorectal cancer is 1 in 22 (4.49%) for men and 1 in 24 (4.15%) for women.
Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.
The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.
On finding a potential compound for the prevention and treatment of diseases associated with oxidative stress, researchers examined the antioxidant activity of Angelica dahurica extract in the HT-29 colon cancer cell line.
According to the A HPLC-DAD analysis, the antioxidant anti-cancer activity of the extract was attributed to the phytochemicals Imperatorin and isoimperatorin, the major coumarins in the ethanol-ethyl acetate active fraction.
In other words, Angelica dahurica extract exerted the antioxidant cancer effect by activating the pro-apoptotic proteins caspase cascade and cell cycle arrest and inhibiting the proteins associated with anti-apoptotic expressions
Based on the results, researchers said, "the ant-cancer activity of the organic extract of Angelica dahurica Radix against colon cancer cells".
Taken altogether, Herbal Angelica consists of the ethanol-ethyl acetate active fraction may be considered a functional herbal medicine for improving antioxidant activity against colon cancer, pending to larger sample size and multicenter human study.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Anti-oxidant and anti-cancer activities of Angelica dahurica extract via induction of apoptosis in colon cancer cells by Zheng YM1, Shen JZ2, Wang Y2, Lu AX2, Ho WS. (PubMed)
Antimigraine
(1) Chemical Composition and Antimigraine Activity of Essential Oil of Angelicae dahuricae Radix. by Sun J1, Li H2, Sun J2, Liu H3, Chen J2, Wang C. (PubMed)
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