Herbal Dandelion(Taraxacum Officinale) Exerts an Inhibitory Activity Against the Risk of Metabolic Syndrome

A metabolic syndrome is a group of conditions associated with an increased risk of cardiovascular disease and types 2 diabetes, including high blood pressure, sugar, cholesterol, triglyceride levels, and excess body fat around the waist.


Cardiovascular diseases refer to heart diseases, affecting millions of people in the world. According to statistics, over 17.7 million people died from CVDs in 2015, Hyperlipidaemia and hypertension are the risk factors for the diseases.


Diabetes is a chronic condition caused by insufficient insulin entering the bloodstream to regulate glucose.

In other words, diabetes occurs when cells in the pancreas die off or receptor sites are clogged up by fat and cholesterol. In some cases, diabetes is also caused by allergic reactions of cells in the immune system.

According to statistics, metabolic syndrome is a growing prevalence in the Western world, In the US, 30% of Americans are living with metabolic syndrome,

In other words, 1 in 5 people in Canada has metabolic syndrome, affecting 19.1% of all Canadian adults.

The CDC statistic suggested, that among US adults aged 18 years or older, the prevalence of metabolic syndrome rose by more than 35% from 25.3% to 34.2% according to the data from 1988–1994 to 2007–2012.

The most common metabolic syndrome are age, family history of metabolic syndrome, physical activity, and women diagnosed with polycystic ovary syndrome.

Symptoms of signs of metabolic syndrome depend on the types of affected conditions and complications.

Dandelion is a herbaceous perennial plant, genus Taraxacum, belongings to the family Asteraceae, native to temperate regions of the world. It has been used in traditional and herbal medicine to treat gout, eczema, acne, gall bladder, kidney, liver, and urinary disorders, hypoglycemia, dyspepsia with constipation, edema, blood pressure, heart weakness, chronic joint, skin diseases, etc.

On finding a natural ingredient for the prevention and treatment of cardiovascular diseases, scientists examined the effects of Boldocynara® (Cynara scolymus, Silybum marianum, Taraxacum officinale, and Peumus boldus) as a combination product and its individual extracts on key enzymes relevant to metabolic syndrome.

According to the tested differentiation, the combination exerted moderate to weak effects on the tested liver enzymes against metabolic syndrome.


In the individual herb analysis, * Peumus boldus extract exhibited pronounced inhibitory activities on α-glucosidase (80% inhibition at 100 µg/ml, IC50: 17.56 µg/ml) associated with a metabolic modifier that could reduce the risk of CVD in patients with the metabolic syndrome.


* Silybum marianum had moderate pancreatic lipase (PL) inhibitory activities (30% at 100 µg/ml) involved in lipid metabolism disorder.

* Cynara scolymus showed moderate ACE inhibitory activity (31% at 100 µg/ml) in reducing the risk of CVD.

In other words, all individual herbal medicine work synergistically to induce inhibitory activity against all parameters in inducing the risk of metabolic syndrome.

Based on the results, researchers suggest, " our results indicate some moderate potential of the dietary supplement Boldocynara® and its single ingredients for the prevention of metabolic disorders".


Taken altogether, Dandelion used in a combination with other herbs may be considered a formula for the prevention of metabolic syndrome, pending the confirmation of the larger sample size and multicenter human study.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) In vitro inhibitory potential of Cynara scolymus, Silybum marianum, Taraxacum officinale, and Peumus boldus on key enzymes relevant to metabolic syndrome by Villiger A1, Sala F1, Suter A2, Butterweck V. (PubMed)