Saturday, July 23, 2022
Herbal Ashwagandha Inhibits the Onset of Progression of HIV Infection
Human immunodeficiency virus -1 (HIV-1) is one of 2 types of HIV precipitated by acquired immunodeficiency syndrome (AIDS), transmitted through direct contact with HIV-infected body fluids, including blood, semen, and genital secretions,...
Human immunodeficiency virus HIV-1 is the most widespread type worldwide that can lead to acquired immunodeficiency syndrome (AIDS).
Acquired immunodeficiency syndrome (AIDS) is a chronic condition caused by the infection of the human immunodeficiency virus (HIV).
According to statistics, AIDS is the fifth leading cause of death in the US.
People between the ages 25 and 44 in the United States are at substantially higher risk compared to other age groups.
Approximately 36.7 million people worldwide lived with HIV/AIDS in 2016, including, 2.1 million children less than 15 years of age.
According to epidemiological studies, people who serval sexual partners are the most at risk of HIV infection.
However, the virus can also transmit through infected blood transfusion, infected mothers to children.
Most people infected by the HIV virus may experience symptoms of fever, muscle aches, and joint pain similar to those of influenza in the early stage of the viral attacks.
According to epidemiological studies, people who have serval sexual partners are the most at risk of HIV infection.
However, the virus can also transmit through infected blood transfusion, infected mothers to children.
If untreated, the virus will slowly multiply and destroy the cells of the immune system, leading to chronic signs and symptoms of fever, fatigue, and swollen lymph nodes,...
If an infected individual has the numbers of T-cell count below 200, the person is considered to have AIDs.
Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.
The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine for over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered an anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
In the urgency to discover a natural ingredient for the prevention of infectious diseases, researchers examined the clinical efficacy and safety of a new polyherbal preparation, Immu-25, in HIV-infected patients.
The open-label pilot study. included 36 patients (10 female, 26 male) with a mean age of 35 +/-10 years, with confirmed HIV infection with a CD4 count <500 cells/microL, and received two capsules of the test drug twice daily for 18 months.
According to the results of the study, the polyherbal preparation produced good symptomatic improvement within 6 months with an increase in mean (95% CI) weight from 58 (53-64)kg to 63 (56-69)kg, 64 (58-72)kg and 68 (62-74)kg after 6, 12 and 18 months of treatment, respectively.
The application decreased the incidence and severity of symptoms such as diarrhea, fatigue, anorexia, cough, and fever in the participants.
Furthermore, there was a decrease in the mean (95% CI) viral load from 326 438 (428 600-186 420) copies/mL to 180 495 (258 300-124 000) copies/mL and 22 069 (42 100-16 000) copies/mL after 6 and 12 months of treatment, respectively.
Most importantly, the decrease in viral load was associated with an increase in mean (95% CI) CD4 count from a baseline of 243 (203-388) cells/microL to 336 (263-486) cells/microL after 6 months of therapy, and this continued to rise to 527 (285-767) cells/microL (p < 0.001) and 618 (362-1012) cells/microL (p < 0.001) after 12 and 18 months of treatment, respectively.
However, mild gastrointestinal adverse effects had been reported by some of the participants.
Based on the evidence, researchers said, "herbal drug may have a good immunomodulatory effect and has potential as a co-therapeutic agent in the management of HIV infection. Further studies are warranted to confirm its therapeutic potential".
Taken altogether, Ashwagandha may be considered supplements for the prevention and treatment of HIV infection, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Evaluation of the antiretroviral activity of a new polyherbal drug (Immu-25) in patients with HIV infection by Usha PR1, Naidu MU, Raju YS. (PubMed)
Saturday, July 9, 2022
Arctostaphylos uva-ursi, the Potential and Natural Anti Type 4 Hypersensitivity with No Side Effects, Scientists Find
Scientists may have found a herbal medicine for the prevention and treatment of type 4 hypersensitivity with no side effects, according to studies.
Type 4 allergy or type 4 hypersensitivity is often called delayed-type hypersensitivity as the reaction takes several days to develop.
In other words, instead of happening right the way as that of other types, type 4 hypersensitivity typically develops at least 48 hours after exposure to an antigen.
The process that develops type 4 hypersensitivity involved the activation of the white blood cell cells in stimulating the release of cytokines and chemokines, and macrophages and cytotoxic CD8+ T cells associated with the body's adaptive immune response.
Compared to other types of allergy mediated by the antibody, type 4 allergy is a cell-mediated response.
Type 4 hypersensitivity can induce allergic contact dermatitis, occurred at the site where the antigen contacts the skin, then spread to other regions through contamination of the antigen.
Type 4 hypersensitivity is caused by atopic dermatitis, lung diseases associated with hypersensitivity, type 2 diabetes, and inflammation of the thyroid gland.
Treatment of type 4 hypersensitivity is totally depending on the severity of the disease. however, the most appropriate approach is to avoid the offending antigen.
Arctostaphylos uva-ursi is one of the species of Bearberry, in the genus Arctostaphylos, belonging to the family Ericaceae, native to northern North America, Asia, and Europe.
The herb has been used in traditional medicine as a diuretic agent and to treat urinary problems, including bladder infections, kidney infections, kidney stones, pelvic pain, etc.
The herbal plant contains arbutin, ursolic acid, tannic acid, gallic acid, some essential oil and resin, hydroquinones tannins, phenolic glycosides, and flavonoids.
In the concern of the widespread of Type IV hypersensitivity caused by contact dermatitis, researchers at the Kinki University examined the combined effect of arbutin isolated from the leaves of Arctostaphylos uva-ursi (L.) Spreng. (Bearberry leaf) and indomethacin on Type IV allergic reaction-induced immuno-inflammation, carrageenin-induced edema, and adjuvant-induced arthritis.
Injection of arbutin at a dose of 50 mg/kg 24 h after the application rapidly decreased the swelling of type IV allergic sheep-induced edema and adjuvant-induced arthritis by picryl chloride (PC-CD) compared to no reaction at the divided doses of 50 mg/kg.
Arbutin (p.o.) plus indomethacin (s.c.) exerted highly inhibitory effects on the swelling of PC-CD and sheep red cell delayed-type hypersensitivity (SRBC-DTH) compared to that of indomethacin alone.
Furthermore, arbutin (p.o.) and indomethacin (s.c.) in a given portion were simultaneously administered, the inhibitory effect was more potent than that of indomethacin alone in both carrageenin-induced edema and adjuvant-induced arthritis.
The results clearly suggested that arbutin may increase the inhibitory action of indomethacin on PC-CD, and SRBC-DTH against type 4 hypersensitivity.
Moreover, in the comparison of water extract (UW-ext) from the leaf of Arctostaphylos uva-ursi (L.) Spreng (Bearberry leaf) on the antiallergic and anti-inflammatory activities of dexamethasone ointment, researchers found one or 2% UW-ext ointment did not inhibit the ear swelling by picryl chloride-induced contact dermatitis (PC-CD) and carrageenin-induced paw edema.
However, combined with dexamethasone ointment (0.005 or 0.025%), UW-ext augmented the inhibitory effect of dexamethasone ointment (0.005 or 0.025%) on these allergic and inflammatory models with no side effects.
These findings showed that not all parts of herbal Arctostaphylos uva-ursi process anti-type 4 allergies, but combined with other therapy all parts augmented the significant anti-allergic and inflammatory activity with no side effects.
Additionally, the investigation of the antitype 4 allergies properties of the combined effect of 50% methanolic extract from Arctostaphylos uva-ursi (L.) Spreng. (bearberry leaf) and prednisolone also showed similar results as illustrated by the above 2 studies.
U-ext did not show an inhibitory effect on the swelling induced by PC-CD in divided doses of 100mg/kg immediately before and 16 h after the application of PC-CD, while it exhibited a significant therapeutic effect at a dose of 100 mg/kg or more once 24 h after the application.
Injection of the combination of U-ext (p.o.) and prednisolone (s.c.) simultaneously administered, exerted a greater inhibitory effect compared to that of prednisolone alone.
Researchers at the above studies wrote in the final report, "Bearberry leaf possesses a therapeutic effect against immuno-inflammation induced by PC-CD and also increases the inhibitory effect of prednisolone, and its active principle may be arbutin".
Taken altogether, herbal Herbal Arctostaphylos uva-ursi (Bearberry) may be considered a functional remedy for the prevention and combined with primary medicines for the treatment of type 4 hypersensitivity with no side effects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) [Pharmacological studies on leaf of Arctostaphylos uva-ursi (L.) Spreng. V. Effect of water extract from Arctostaphylos uva-ursi (L.) Spreng. (bearberry leaf) on the antiallergic and antiinflammatory activities of dexamethasone ointment].[Article in Japanese] by Matsuda H, Nakamura S, Tanaka T, Kubo M.(PubMed)
(2) [Pharmacological studies on leaf of Arctostaphylos uva-ursi (L.) Spreng. III. Combined effect of arbutin and indomethacin on immuno-inflammation].[Article in Japanese] by Matsuda H, Tanaka T, Kubo M.(PubMed)
(3) [Pharmacological studies on leaf of Arctostaphylos uva-ursi (L.) Spreng. I. Combined effect of 50% methanolic extract from Arctostaphylosuva-ursi (L.) Spreng. (bearberry leaf) and prednisolone on immuno-inflammation].[Article in Japanese] by Kubo M, Ito M, Nakata H, Matsuda H.(PubMed)
Type 4 allergy or type 4 hypersensitivity is often called delayed-type hypersensitivity as the reaction takes several days to develop.
In other words, instead of happening right the way as that of other types, type 4 hypersensitivity typically develops at least 48 hours after exposure to an antigen.
The process that develops type 4 hypersensitivity involved the activation of the white blood cell cells in stimulating the release of cytokines and chemokines, and macrophages and cytotoxic CD8+ T cells associated with the body's adaptive immune response.
Compared to other types of allergy mediated by the antibody, type 4 allergy is a cell-mediated response.
Type 4 hypersensitivity can induce allergic contact dermatitis, occurred at the site where the antigen contacts the skin, then spread to other regions through contamination of the antigen.
Type 4 hypersensitivity is caused by atopic dermatitis, lung diseases associated with hypersensitivity, type 2 diabetes, and inflammation of the thyroid gland.
Treatment of type 4 hypersensitivity is totally depending on the severity of the disease. however, the most appropriate approach is to avoid the offending antigen.
Arctostaphylos uva-ursi is one of the species of Bearberry, in the genus Arctostaphylos, belonging to the family Ericaceae, native to northern North America, Asia, and Europe.
The herb has been used in traditional medicine as a diuretic agent and to treat urinary problems, including bladder infections, kidney infections, kidney stones, pelvic pain, etc.
The herbal plant contains arbutin, ursolic acid, tannic acid, gallic acid, some essential oil and resin, hydroquinones tannins, phenolic glycosides, and flavonoids.
In the concern of the widespread of Type IV hypersensitivity caused by contact dermatitis, researchers at the Kinki University examined the combined effect of arbutin isolated from the leaves of Arctostaphylos uva-ursi (L.) Spreng. (Bearberry leaf) and indomethacin on Type IV allergic reaction-induced immuno-inflammation, carrageenin-induced edema, and adjuvant-induced arthritis.
Injection of arbutin at a dose of 50 mg/kg 24 h after the application rapidly decreased the swelling of type IV allergic sheep-induced edema and adjuvant-induced arthritis by picryl chloride (PC-CD) compared to no reaction at the divided doses of 50 mg/kg.
Arbutin (p.o.) plus indomethacin (s.c.) exerted highly inhibitory effects on the swelling of PC-CD and sheep red cell delayed-type hypersensitivity (SRBC-DTH) compared to that of indomethacin alone.
Furthermore, arbutin (p.o.) and indomethacin (s.c.) in a given portion were simultaneously administered, the inhibitory effect was more potent than that of indomethacin alone in both carrageenin-induced edema and adjuvant-induced arthritis.
The results clearly suggested that arbutin may increase the inhibitory action of indomethacin on PC-CD, and SRBC-DTH against type 4 hypersensitivity.
Moreover, in the comparison of water extract (UW-ext) from the leaf of Arctostaphylos uva-ursi (L.) Spreng (Bearberry leaf) on the antiallergic and anti-inflammatory activities of dexamethasone ointment, researchers found one or 2% UW-ext ointment did not inhibit the ear swelling by picryl chloride-induced contact dermatitis (PC-CD) and carrageenin-induced paw edema.
However, combined with dexamethasone ointment (0.005 or 0.025%), UW-ext augmented the inhibitory effect of dexamethasone ointment (0.005 or 0.025%) on these allergic and inflammatory models with no side effects.
These findings showed that not all parts of herbal Arctostaphylos uva-ursi process anti-type 4 allergies, but combined with other therapy all parts augmented the significant anti-allergic and inflammatory activity with no side effects.
Additionally, the investigation of the antitype 4 allergies properties of the combined effect of 50% methanolic extract from Arctostaphylos uva-ursi (L.) Spreng. (bearberry leaf) and prednisolone also showed similar results as illustrated by the above 2 studies.
U-ext did not show an inhibitory effect on the swelling induced by PC-CD in divided doses of 100mg/kg immediately before and 16 h after the application of PC-CD, while it exhibited a significant therapeutic effect at a dose of 100 mg/kg or more once 24 h after the application.
Injection of the combination of U-ext (p.o.) and prednisolone (s.c.) simultaneously administered, exerted a greater inhibitory effect compared to that of prednisolone alone.
Researchers at the above studies wrote in the final report, "Bearberry leaf possesses a therapeutic effect against immuno-inflammation induced by PC-CD and also increases the inhibitory effect of prednisolone, and its active principle may be arbutin".
Taken altogether, herbal Herbal Arctostaphylos uva-ursi (Bearberry) may be considered a functional remedy for the prevention and combined with primary medicines for the treatment of type 4 hypersensitivity with no side effects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) [Pharmacological studies on leaf of Arctostaphylos uva-ursi (L.) Spreng. V. Effect of water extract from Arctostaphylos uva-ursi (L.) Spreng. (bearberry leaf) on the antiallergic and antiinflammatory activities of dexamethasone ointment].[Article in Japanese] by Matsuda H, Nakamura S, Tanaka T, Kubo M.(PubMed)
(2) [Pharmacological studies on leaf of Arctostaphylos uva-ursi (L.) Spreng. III. Combined effect of arbutin and indomethacin on immuno-inflammation].[Article in Japanese] by Matsuda H, Tanaka T, Kubo M.(PubMed)
(3) [Pharmacological studies on leaf of Arctostaphylos uva-ursi (L.) Spreng. I. Combined effect of 50% methanolic extract from Arctostaphylosuva-ursi (L.) Spreng. (bearberry leaf) and prednisolone on immuno-inflammation].[Article in Japanese] by Kubo M, Ito M, Nakata H, Matsuda H.(PubMed)
Sunday, July 3, 2022
Herbal Turmeric Optimizes the Intestinal Mucosal Barrier Function Against Pathogens
Intestinal mucosa processes a single cell layer of epithelial cells with a function to protect the intestine against invasive pathogens and ensure the function of the intestinal in nutrients adsorption.
Biologically, the intestinal protection of the intestinal mucosal barrier function is associated with
*Bile and gastric acid produced in the liver and stomach that only aid digestion but kills microorganism
* Defensins secretory epithelial cells with a function to protect the intestines against bacteria, fungi and many enveloped and nonenveloped viruses.
* Lysozyme is an enzyme that protects the intestine by causing the destruction of the cell walls of certain bacteria.
* Regenerating islet-derived protein 3 gammas (Reg3γ), an antibacterial lectin is a type of antimicrobial peptide found in the gut epithelial Paneth cells with a function to prevent microorganisms from coming into contact with the epithelial layer.
In other words, the intestinal mucosal barrier plays an essential role in the separation of the inside of the body from the outside environment, particularly in harmful microorganisms.
Dr. Oshima T the lead scientist in the examination of light junctions (TJs), the most important component for the construction of a constitutive barrier of epithelial cells that regulates the permeability of the barrier by tightly sealing the cell-cell junctions, wrote, "Gastrointestinal diseases including reflux esophagitis, inflammatory bowel disease, functional gastrointestinal disorders, and cancers may be regulated by these molecules, and disruption of their functions leads to chronic inflammatory conditions and chronic or progressive disease".
And, "regulation of the barrier function of epithelial cells by regulating the expression and localization of TJ proteins is a potential new target for the treatment of these diseases".
More precisely, by improving the intestinal mucosal barrier function, diseases associated with the gastrointestinal tract may be preventable.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, appetite loss, ulcers, eczema, inflammations, etc.
With an aim to find a potential ingredient for the protection of the intestinal mucosal barrier, researchers examined the effects of curcumin's extensive pharmacological effects, on gastrointestinal diseases.
According to the analysis, curcumin exerted protective effects on the intestinal mucosal barrier through multiple pathways.
More precisely, curcumin protected the tissues of the intestinal mucosal barrier by
* By reducing the production of proinflammatory cytokines in orchestrating cell damage.
* By inhibiting the oxidative stress caused by overexpression of free radicals in facilitating the onset of chronic inflammation in the initiation of intestinal mucosal damage.
* By reducing levels of bacteria in the induction of infection that may weaken the function of the intestinal mucosal barrier.
Moreover, curcumin also protected the cells of intestinal mucosa against apoptosis.
In additional differentiation of the tested assays, researchers also found that curcumin also balances the ratio of gut microbiota associated with the regulation of intestinal microecology and intestinal immune response which plays a critical role in enhancing the intestinal mucosal barrier function.
Taken altogether, turmeric may be considered a supplement for the improvement of intestinal mucosal barrier function, pending the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of a supplement should be taken with extreme care to prevent overdose and acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional's Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) [Advances in the research of protective effect of curcumin on intestinal mucosalbarrier function].
[Article in Chinese; Abstract available in Chinese from the publisher] by He D1, Wang S2, Hu H2, Yin HY2. (PubMed)
(2) Gastrointestinal mucosal barrier function and diseases by Oshima T1, Miwa H. (PubMed)
Biologically, the intestinal protection of the intestinal mucosal barrier function is associated with
*Bile and gastric acid produced in the liver and stomach that only aid digestion but kills microorganism
* Defensins secretory epithelial cells with a function to protect the intestines against bacteria, fungi and many enveloped and nonenveloped viruses.
* Lysozyme is an enzyme that protects the intestine by causing the destruction of the cell walls of certain bacteria.
* Regenerating islet-derived protein 3 gammas (Reg3γ), an antibacterial lectin is a type of antimicrobial peptide found in the gut epithelial Paneth cells with a function to prevent microorganisms from coming into contact with the epithelial layer.
In other words, the intestinal mucosal barrier plays an essential role in the separation of the inside of the body from the outside environment, particularly in harmful microorganisms.
Dr. Oshima T the lead scientist in the examination of light junctions (TJs), the most important component for the construction of a constitutive barrier of epithelial cells that regulates the permeability of the barrier by tightly sealing the cell-cell junctions, wrote, "Gastrointestinal diseases including reflux esophagitis, inflammatory bowel disease, functional gastrointestinal disorders, and cancers may be regulated by these molecules, and disruption of their functions leads to chronic inflammatory conditions and chronic or progressive disease".
And, "regulation of the barrier function of epithelial cells by regulating the expression and localization of TJ proteins is a potential new target for the treatment of these diseases".
More precisely, by improving the intestinal mucosal barrier function, diseases associated with the gastrointestinal tract may be preventable.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, appetite loss, ulcers, eczema, inflammations, etc.
With an aim to find a potential ingredient for the protection of the intestinal mucosal barrier, researchers examined the effects of curcumin's extensive pharmacological effects, on gastrointestinal diseases.
According to the analysis, curcumin exerted protective effects on the intestinal mucosal barrier through multiple pathways.
More precisely, curcumin protected the tissues of the intestinal mucosal barrier by
* By reducing the production of proinflammatory cytokines in orchestrating cell damage.
* By inhibiting the oxidative stress caused by overexpression of free radicals in facilitating the onset of chronic inflammation in the initiation of intestinal mucosal damage.
* By reducing levels of bacteria in the induction of infection that may weaken the function of the intestinal mucosal barrier.
Moreover, curcumin also protected the cells of intestinal mucosa against apoptosis.
In additional differentiation of the tested assays, researchers also found that curcumin also balances the ratio of gut microbiota associated with the regulation of intestinal microecology and intestinal immune response which plays a critical role in enhancing the intestinal mucosal barrier function.
Taken altogether, turmeric may be considered a supplement for the improvement of intestinal mucosal barrier function, pending the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of a supplement should be taken with extreme care to prevent overdose and acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional's Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) [Advances in the research of protective effect of curcumin on intestinal mucosalbarrier function].
[Article in Chinese; Abstract available in Chinese from the publisher] by He D1, Wang S2, Hu H2, Yin HY2. (PubMed)
(2) Gastrointestinal mucosal barrier function and diseases by Oshima T1, Miwa H. (PubMed)
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