Sunday, August 27, 2023
#Herbal #Andrographis Inhibits the Risk of #HeartDisease, Researcher Say
Herbal Andrographis may process certain bioactive compounds for the prevention and treatment of heart diseases, some scientists suggested.Heart disease is the medical condition associated with the blood vessels, including coronary artery disease, heart rhythm, and a heart defect caused by the accumulation of plaques.
Plaque made up of cholesterol, fatty molecules, and minerals accumulated in the arteries can cause stiffening and hardening of the arterial wall and narrowing of the arteries, affecting the transportation of oxygen risk blood to the heart.
These result suggested that people who follow the Western diet high in saturated and trans fat, red med meat and processed foods and over the use of calcium supplement are associated with the increased risk plaque building up.
Long-term building-up plaques can cause substantial damage to the arterial wall, facilitating the onset of heart disease.
According to statistics, heart disease kills more than 2,000 Americans every day and approximately 60 million Americans have heart disease.
The exact causes of heart disease are debatable. Researchers do not why people who over a few decades of following the Western diet, only some are susceptible to heart disease while many do not, even they have the same health conditions.
The differentiation suggested that some people may process certain genetic prepositions which
can increase the development of heart disease.
Dr. Seka Kathiresan, the lead scientist in the study"Genetics of Human Cardiovascular Disease" Cardiovascular disease encompasses a range of conditions extending from myocardial infarction to congenital heart disease most of which are heritable", and
"ANGPTL3mutations as a cause of familial combined hypolipidemia, BAG mutations for dilated cardiomyopathy, NT5E mutations for arterial calcification, KCNJ5 mutations for hereditary hypertension due to aldosterone-producing adenomas, and KLHL3 or CUL3mutations for hypertension and hyperkalemia".
Other risk factors, according to epidemiological studies include obesity insulin resistance or diabetes, high cholesterol and blood pressure, being physically inactive, smoking, and eating an unhealthy diet are also associated with disease onset.
However, most people who carry some of the risk factors have never developed heart disease.
Andrographis paniculata is also known as Andrographis is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka.
The plant has been used in traditional Siddha and Ayurvedic in treating the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia, swollen lymph nodes, leprosy, bronchitis, sore throats, tuberculosis, chicken pox, etc.
In the concern of ischemia-reperfusion (I-R) injury in the increase of the complication of myocardial infarction (MI), researchers at the All India Institute of Medical Sciences conducted a study with an aim to find a natural ingredient or whole herb which processes a cardioprotective effect.
In the rat model, hydroalcoholic extract of Andrographis paniculata was evaluated against the left anterior descending coronary artery (LADCA) ligation-induced I-R injury of the myocardium.
Selected MI rats were induced by LADCA ligation for 45 min followed by reperfusion for 60 min and divided into five experimental groups viz., sham (saline-treated, but LADCA was not ligated), I-R control (saline-treated + I-R), benazepril (30 mg/kg + I-R), A. paniculata (200 mg/kg per se) and A. paniculata (200 mg/kg + I-R).
* In the I-R control group, LADCA ligation showed a significant cardiac dysfunction evidenced by reduced hemodynamic parameters; mean arterial pressure (MAP), and heart rate (HR).
* The I-R control without treatment of the herbal extract expressed a decline of antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione (GSH) but enhanced lipid peroxidation product, malondialdehyde (MDA), a marker of oxidative stress.
After 30 days of 200 mg/kg A. paniculata administered orally, the treated group showed favorable improvement in hemodynamic and left ventricular contractile function, restoration of the myocardial antioxidants, and prevention of depletion of myocytes injury marker enzymes along with inhibition of lipid peroxidation.
The results indicated that 200 mg/kg A. paniculata demonstrated a significant cardioprotective activity by inhibiting the adverse effect caused by LADCA in the rat model.
Dr. Ojha SK, the lead author said. "The cardioprotective effects of A. paniculata were found comparable to that of benazepril treatment".
Additionally, in reaffirming the cardioprotective effect of herbal Andrographis, researchers launched an investigation to examine the watery extract of Andrographis paniculata Nees (APN) activity after one hour of the development of myocardial infarction by the formation of a thrombus.
13 dogs were included in the study with 6 of the was served as a control group.
The Andrographis treatment group showed clinically significant efficacy in the improvement of the myocardial structure surrounding the initially appearing ischemic area.
Andrographis exerted a cardioprotective effect in a reversal of the damaged area by restoring the damaged area.
The degree of myocardial degeneration and necrosis in the central part of the ischemic area was mild. in the treatment, dogs compared to the control.
These observations strongly suggested that APN processes cardioprotection by limiting the expansion of ischemic focus, accelerating the reversibly ischemic myocardium.
Taken together, herbal Andrographis may be considered a functional food for the prevention and an adjunct therapy combined with the primary medicine for the treatment of heart disease.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Saturday, August 12, 2023
Tocopherols Reduce the Risk and Progression of Prostate Cancer in Vivo
The prostate gland wrapped around around a tube (the urethra), is a gland of the male reproductive system found in front of the rectum and just below the bladder.
The prostate gland is a gland that makes and stores semen. It is located below the bladder and surrounds the tube that carries urine out of your body.
Additionally, the muscles of the prostate gland also play a critical role in propelling seminal fluid into the urethra during ejaculation
Symptoms of an enlarged prostate are associated with a natural impend the conversion of testosterone to DHT. Unfortunately, aging is not the only cause of enlarged prostate.
Prostate cancer is a medical and chronic condition caused by the growth of cells irregularly in the tissue of the prostate.
Most cases of prostate cancer start in the cells on the surface of the inner lining of the prostate gland.
According to the statistic provided by the Canadian Cancer Society, prostate cancer is the third most common cancer among Canadian men and the 3rd leading cause of death from cancer in men in Canada.
In 2017, approximately 21,300 men were diagnosed with prostate cancer, accounting for 21% of all new cancer cases in men.
Furthermore, approximately 1 in 7 Canadian men will develop prostate cancer during his lifetime and 1 in 29 will die from it.
The 5-year survival rate for most men with local or regional prostate cancer is nearly 100%.
In other words, For men diagnosed with prostate cancer that has not spread to other parts of the body, the 5-year survival rate is 100%.
However, the 5 years survival rate of prostate cancer that has spread to other parts of the body, is only 30%.
Tocopherols are phytochemicals of which many have vitamin E activity, belonging to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, and seed or nut oils, etc.
On finding a potential phytochemical for the treatment of chronic diseases, researchers examined the effect of tocopherols on prostate cancer.
The study included specific Pten-/- (Ptenp-/-) mice induced cancer by activation of AKT cancer promotion signaling, fed by Ptenp-/- mice with AIN93M or 0.2% δ-T supplemented diet, at the age of 6 or 12 weeks.According to the analysis,
* δ-T treatment reduced prostate adenocarcinoma multiplicity at the age of 40 weeks by 53.3 and 42.7%, respectively.
* Furthermore, the phosphorylation of AKT (T308) that promotes cancer growth and survival was reduced in the prostate of the mice administered the δ-T diet.
* δ-T diet also, reduced proliferation and increased apoptosis in the prostate cancer cell line without affecting the oxidative stress.
Interestingly, α-tocopherol (α-T) at 0.2% in the diet exhibited anti-prostate cancer cell activity with no effects on prostate adenocarcinoma multiplicity in the Ptenp-/- mice.
After taking other factors into account, researchers said, " δ-T inhibits the development of prostate adenocarcinoma in Ptenp-/- mice, mainly through inhibition of AKT activation".
Taken together, tocopherols may be considered an adjunct therapy in the treatment of prostate cancer, pending the confirmation of the larger sample size and multicenter human study.
Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.Norton's
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the prostate-specificinternational journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Carotenoids, retinol, tocopherols, and prostate cancer risk: a pooled analysis of 15 studies by Key TJ1, Appleby PN2, Travis RC2, Albanes D3, Alberg AJ4, Barricarte A5, Black A3, Boeing H6, Bueno-de-Mesquita HB7, Chan JM8, Chen C9, Cook MB3, Donovan JL10, Galan P11, Gilbert R10, Giles GG12, Giovannucci E13, Goodman GE14, Goodman PJ15, Gunter MJ16, Hamdy FC17, Heliövaara M18, Helzlsouer KJ19, Henderson BE20, Hercberg S11, Hoffman-Bolton J21, Hoover RN3, Johansson M22, Khaw KT23, King IB24, Knekt P18, Kolonel LN25, Le Marchand L25, Männistö S18, Martin RM26, Meyer HE27, Mondul AM3, Moy KA3, Neal DE28, Neuhouser ML29, Palli D30, Platz EA31, Pouchieu C12, Rissanen H18, Schenk JM32, Severi G12, Stampfer MJ13, Tjønneland A33, Touvier M11, Trichopoulou A34, Weinstein SJ3, Ziegler RG3, Zhou CK3, Allen NE35; Endogenous Hormones Nutritional Biomarkers Prostate Cancer Collaborative Group. (PubMed)
(2) δ-Tocopherol inhibits the development of prostate adenocarcinoma in prostate specific Pten-/- mice by Wang H1, Yang X1, Liu A1, Wang G2, Bosland MC3, Yang CS. (PubMed)
Tuesday, May 16, 2023
#Pintobeans Lower Non-HDL Cholesterol Levels in Vivo, Researchers Find
Cholesterol is a waxy substance carried around by lipoproteins, that do not mix with water-based blood in our body.
Cholesterol is needed for our body to build cell walls and make hormones and vitamin D, and create bile salts that help to digest fat, particularly in the building of strong cell membranes. However, too much of it can be dangerous because cholesterol cannot dissolve in your blood.
There are 2 types of cholesterol. The low-density lipoprotein is also known as bad cholesterol which performs the aforementioned activity in the right levels and the high-density lipoprotein which returns cholesterol back to the liver for reuse.
However, overexpression of cholesterol can cause plaque building up on the arterial wall, leading to arterial narrowing, wall stiffness, and hardening, some major causes of heart disease and stroke.
Although high blood cholesterol does not induce any symptoms, a prolonged period of uncontrolled high blood cholesterol can cause complications of chest pain, the early sign of coronary artery disease, heart attack,.... and stroke.
According to medical guidelines, the normal goal of non-HDL cholesterol levels should be 30 mg/dL higher than the LDL cholesterol level.
For example, if your non-HDL cholesterol level= is LDL cholesterol.+ 30 mg/dL = 130 mg/dL and your HDL is 40 mg/dL = Non-HDL-c/HDL-c ratio of 3.25, the ideal range of the ratio.
The healthy ratio of blood cholesterol is 4 (LDL)/1 (HDL). If you have a number that is lowers than 4, you have healthy blood cholesterol.
Hyperlipidemia is one member of the cluster conditions of metabolic syndrome, therefore, if you have a number that is higher than 4, your risk of cardiovascular is increased compared to people with healthy levels.
On finding a natural ingredient for the prevention and treatment of diseases associated with high blood cholesterol, scientists examined the changes in cholesterol metabolism in response to whole pinto beans (wPB) and their hulls (hPB) supplemented into a diet rich in saturated fat in hamsters.
The pinto bean is also known as the common bean, genus Phaseolus and the family Fabaceae. It has a mottled appearance of darker reddish-brown spots on a lighter brownish-beige background, thus appearing painted or spotted.
The study included forty-four 9-wk-old male Golden Syrian hamsters that were randomly assigned to 4 diet groups (n = 11), including a 5% (wt:wt) fat diet [normal-fat diet (NF)], a 15% (wt:wt) fat diet [diet rich in saturated fat (HSF), saturated fatty acids accounted for 70% of total fatty acids], or HSF supplemented with 5% (wt:wt) wPB or 0.5% (wt:wt) hPB for 4 wk.
According to the plasma, liver, intestinal, and fecal samples that were collected to evaluate multiple cholesterol markers and gene targets,
* The plasma non-high-density lipoprotein (non-HDL) concentration was significantly reduced in the wPB- and hPB-supplemented groups by 31.9 ± 3.5% and 53.6 ± 3.2%, respectively, compared to the HSF group (P < 0.01), to concentrations comparable with the NF group
* The wPB-supplemented hamsters had significantly lower liver cholesterol (45.1%, P < 0.001) and higher fecal cholesterol concentrations (94.8%, P = 0.001) than those of the HSF group.
* The expressions of hepatic 3-hydroxy-3-methylglutaryl CoA reductase (Hmgcr) and small intestinal acyl-coenzyme A: cholesterol acyltransferase 2 (Acat2) associated with the elevation of blood cholesterol were significantly decreased in animals administered wPB (by 89.1% and 63.8%, respectively) and hPB (by 72.9% and 47.7%, respectively) compared to the HSF-fed counterparts (P < 0.05).
Based on the results, researchers suggest, "Pinto beans remediated high cholesterol induced by HSF in male hamsters by decreasing hepatic cholesterol synthesis and intestinal cholesterol absorption, effects which were partially exerted by the hulls".
Taken altogether, Pinto beans may be considered s functional for the treatment of high blood cholesterol, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Pinto Beans (Phaseolus vulgaris L.) Lower Non-HDL Cholesterol in Hamsters Fed a Diet Rich in Saturated Fat and Act on Genes Involved in Cholesterol Homeostasis by Nguyen AT1,2, Althwab S3,4, Qiu H3, Zbasnik R1, Urrea C5, Carr TP3, Schlegel V. (PubMed)
Cholesterol is needed for our body to build cell walls and make hormones and vitamin D, and create bile salts that help to digest fat, particularly in the building of strong cell membranes. However, too much of it can be dangerous because cholesterol cannot dissolve in your blood.
There are 2 types of cholesterol. The low-density lipoprotein is also known as bad cholesterol which performs the aforementioned activity in the right levels and the high-density lipoprotein which returns cholesterol back to the liver for reuse.
However, overexpression of cholesterol can cause plaque building up on the arterial wall, leading to arterial narrowing, wall stiffness, and hardening, some major causes of heart disease and stroke.
Although high blood cholesterol does not induce any symptoms, a prolonged period of uncontrolled high blood cholesterol can cause complications of chest pain, the early sign of coronary artery disease, heart attack,.... and stroke.
According to medical guidelines, the normal goal of non-HDL cholesterol levels should be 30 mg/dL higher than the LDL cholesterol level.
For example, if your non-HDL cholesterol level= is LDL cholesterol.+ 30 mg/dL = 130 mg/dL and your HDL is 40 mg/dL = Non-HDL-c/HDL-c ratio of 3.25, the ideal range of the ratio.
The healthy ratio of blood cholesterol is 4 (LDL)/1 (HDL). If you have a number that is lowers than 4, you have healthy blood cholesterol.
Hyperlipidemia is one member of the cluster conditions of metabolic syndrome, therefore, if you have a number that is higher than 4, your risk of cardiovascular is increased compared to people with healthy levels.
On finding a natural ingredient for the prevention and treatment of diseases associated with high blood cholesterol, scientists examined the changes in cholesterol metabolism in response to whole pinto beans (wPB) and their hulls (hPB) supplemented into a diet rich in saturated fat in hamsters.
The pinto bean is also known as the common bean, genus Phaseolus and the family Fabaceae. It has a mottled appearance of darker reddish-brown spots on a lighter brownish-beige background, thus appearing painted or spotted.
The study included forty-four 9-wk-old male Golden Syrian hamsters that were randomly assigned to 4 diet groups (n = 11), including a 5% (wt:wt) fat diet [normal-fat diet (NF)], a 15% (wt:wt) fat diet [diet rich in saturated fat (HSF), saturated fatty acids accounted for 70% of total fatty acids], or HSF supplemented with 5% (wt:wt) wPB or 0.5% (wt:wt) hPB for 4 wk.
According to the plasma, liver, intestinal, and fecal samples that were collected to evaluate multiple cholesterol markers and gene targets,
* The plasma non-high-density lipoprotein (non-HDL) concentration was significantly reduced in the wPB- and hPB-supplemented groups by 31.9 ± 3.5% and 53.6 ± 3.2%, respectively, compared to the HSF group (P < 0.01), to concentrations comparable with the NF group
* The wPB-supplemented hamsters had significantly lower liver cholesterol (45.1%, P < 0.001) and higher fecal cholesterol concentrations (94.8%, P = 0.001) than those of the HSF group.
* The expressions of hepatic 3-hydroxy-3-methylglutaryl CoA reductase (Hmgcr) and small intestinal acyl-coenzyme A: cholesterol acyltransferase 2 (Acat2) associated with the elevation of blood cholesterol were significantly decreased in animals administered wPB (by 89.1% and 63.8%, respectively) and hPB (by 72.9% and 47.7%, respectively) compared to the HSF-fed counterparts (P < 0.05).
Based on the results, researchers suggest, "Pinto beans remediated high cholesterol induced by HSF in male hamsters by decreasing hepatic cholesterol synthesis and intestinal cholesterol absorption, effects which were partially exerted by the hulls".
Taken altogether, Pinto beans may be considered s functional for the treatment of high blood cholesterol, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Pinto Beans (Phaseolus vulgaris L.) Lower Non-HDL Cholesterol in Hamsters Fed a Diet Rich in Saturated Fat and Act on Genes Involved in Cholesterol Homeostasis by Nguyen AT1,2, Althwab S3,4, Qiu H3, Zbasnik R1, Urrea C5, Carr TP3, Schlegel V. (PubMed)
Friday, April 7, 2023
#Ginger and #ShellGinger in the Promotion of Healthy Longevity, According to Studies
Scientists may have a pungent spice that processes a potential for the promotion of healthy longevity, according to the study.
Compared to life expectancy which is the average number of years remaining of a given age or living of a certain group's people, longevity is a long life out of the boundary of the life expectancy.
Truly, we all dream to live healthy and with longevity. However how many of us can maintain health and prevent the onset of chronic disease?
Some researchers suggested that by following a healthy lifestyle and moderate exercise healthy longevity can be achieved.
Dr. Mehta N in the study of the healthy lifestyle impact on life expectancy wrote, "Compared to the whole US population, those with such a favorable behavioral profile had a life expectancy at age fifty that was seven years longer, and they experienced a delay in the onset of disability of up to six years".
The results clearly suggested the massively damaging effects caused by unhealthy behavioral risks on health at older ages.
Furthermore, Dr. Vincent Gremeaux and colleagues on the differentiation of exercise and longevity said, "As the number of older individuals continues to increase, it is important to develop interventions that can be easily implemented and contribute to “successful aging”".
And, " In addition to a healthy diet and psychosocial well-being, the benefits of regular exercise on mortality, and the prevention and control of chronic disease affecting both life expectancy and quality of life are well established".
Regularly moderate exercise has been found to have partially reverse effects on the aging process on physiological functions and preserve functional capability in the elderly.
Epidemiological studies strongly suggested that healthy longevity can be achieved by maintaining a minimum quantity and quality of exercise, preventing the development of certain cancers, and lowering the risk of osteoporosis.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
Researchers on finding a bioactive compound for healthy longevity examined the shell ginger (Alpinia zerumbet (Pers.) B.L. Burtt & R.M. Sm) of the ginger family (Zingiberaceae) activity in the population in the Okinawa Islands of Japan.
According to the review of the literature, culinary shell ginger may contribute to longevity among the population in Okinawa probably due to the procession of phytochemical content with antioxidants and its effects on anti-obesity properties.
Some researchers suggested that the longevity of the population may also be attributed to the shell ginger in the promotion of health in reduced diseases by exhibiting anti-inflammatory, fungistatic, and antibacterial activities against Escherichia coli, Bacillus subtilis, and Bacillus cereus activity.
Shell ginger also is proven to have a positive effect on neuraminidase enzymes and inhibition of human immunodeficiency virus (HIV-1).
Dr. Rolf Teschke in the examination of the mortality rate of Japan's general public compared to the population on the island wrote, "Cardiovascular disease as the top cause of death for both sexes and neoplasms as the second leading cause of death in Japan nationally, with major variations among the prefectures"
And, " Comparing Japan overall with Okinawa, the mean mortality rates from ischaemic heart disease, Alzheimer’s disease, breast cancer, and oesophageal cancer were not remarkably different. However, for Okinawa, four death categories were significantly lower, including ischaemic stroke, stomach cancer, pancreatic cancer, and liver cancer due to hepatitis C.
The finding clearly suggested that the intake of shell ginger which was not found in other areas in Japan may contribute to the healthy longevity of the population in the Okinawa Islands of Japan.
In a joint study led by Woosuk University, Korean scientists evaluated the compound 6-gingerol longevity-promoting activity. isolated from the most active ethyl acetate soluble fraction on Caenorhabditis elegans (C. elegans).
Injection of 6 gingerol elevated the survival rate of worms against stressful environments including thermal, osmotic, and oxidative conditions.
The bioactive compound elevated the antioxidant enzyme activities of C. elegans and showed a dose-depend reduction of intracellular reactive oxygen species (ROS) accumulation in worms.
Furthermore, 6 gingerols also demonstrated increased stress tolerance, leading to the promotion of stress resistance proteins.
The findings strongly suggest that 6-gingerol exerted longevity-promoting activities independently of these factors and could extend the human lifespan.
Taken altogether, ginger and shell ginger may be considered functional foods for the promotion of healthy longevity with no side effects, pending the confirmation of a large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals' Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) Longevity and Stress Resistant Property of 6-Gingerol from Zingiber officinale Roscoe in Caenorhabditis elegans by Eun Byeol Lee,1 Jun Hyeong Kim,1 Chang Wan An,1 Yeong Jee Kim,1 Yun Jeong Noh,1Su Jin Kim,1 Ju-Eun Kim,1 Abinash Chandra Shrestha,1 Ha-Neul Ham,1 Jae-Yoon Leem,1Hyung-Kwon Jo,2 Dae-Sung Kim,2 Kwang Hyun Moon,3 Jeong Ho Lee,3 Kyung Ok Jeong,3 andDae Keun Kim. (PubMed)
(2) Viewpoint: A Contributory Role of Shell Ginger (Alpinia zerumbet) for Human Longevity in Okinawa, Japan? by Rolf Teschke1,* and Tran Dang Xuan. (PMC)
(3) The Population Health Benefits Of A Healthy Lifestyle: Life Expectancy Increased And Onset Of Disability Delayed by Mehta N1, Myrskylä M. (PubMed)
(4) Exercise and longevity by Vincent Gremeaux, Duxabcdef, MathieuGay, RomualdLeperse, Philippe Sosneraghi, MartinJuneau, AnilNigam. (Science Direct)
Truly, we all dream to live healthy and with longevity. However how many of us can maintain health and prevent the onset of chronic disease?
Some researchers suggested that by following a healthy lifestyle and moderate exercise healthy longevity can be achieved.
Dr. Mehta N in the study of the healthy lifestyle impact on life expectancy wrote, "Compared to the whole US population, those with such a favorable behavioral profile had a life expectancy at age fifty that was seven years longer, and they experienced a delay in the onset of disability of up to six years".
The results clearly suggested the massively damaging effects caused by unhealthy behavioral risks on health at older ages.
Furthermore, Dr. Vincent Gremeaux and colleagues on the differentiation of exercise and longevity said, "As the number of older individuals continues to increase, it is important to develop interventions that can be easily implemented and contribute to “successful aging”".
And, " In addition to a healthy diet and psychosocial well-being, the benefits of regular exercise on mortality, and the prevention and control of chronic disease affecting both life expectancy and quality of life are well established".
Regularly moderate exercise has been found to have partially reverse effects on the aging process on physiological functions and preserve functional capability in the elderly.
Epidemiological studies strongly suggested that healthy longevity can be achieved by maintaining a minimum quantity and quality of exercise, preventing the development of certain cancers, and lowering the risk of osteoporosis.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
Researchers on finding a bioactive compound for healthy longevity examined the shell ginger (Alpinia zerumbet (Pers.) B.L. Burtt & R.M. Sm) of the ginger family (Zingiberaceae) activity in the population in the Okinawa Islands of Japan.
According to the review of the literature, culinary shell ginger may contribute to longevity among the population in Okinawa probably due to the procession of phytochemical content with antioxidants and its effects on anti-obesity properties.
Some researchers suggested that the longevity of the population may also be attributed to the shell ginger in the promotion of health in reduced diseases by exhibiting anti-inflammatory, fungistatic, and antibacterial activities against Escherichia coli, Bacillus subtilis, and Bacillus cereus activity.
Shell ginger also is proven to have a positive effect on neuraminidase enzymes and inhibition of human immunodeficiency virus (HIV-1).
Dr. Rolf Teschke in the examination of the mortality rate of Japan's general public compared to the population on the island wrote, "Cardiovascular disease as the top cause of death for both sexes and neoplasms as the second leading cause of death in Japan nationally, with major variations among the prefectures"
And, " Comparing Japan overall with Okinawa, the mean mortality rates from ischaemic heart disease, Alzheimer’s disease, breast cancer, and oesophageal cancer were not remarkably different. However, for Okinawa, four death categories were significantly lower, including ischaemic stroke, stomach cancer, pancreatic cancer, and liver cancer due to hepatitis C.
The finding clearly suggested that the intake of shell ginger which was not found in other areas in Japan may contribute to the healthy longevity of the population in the Okinawa Islands of Japan.
In a joint study led by Woosuk University, Korean scientists evaluated the compound 6-gingerol longevity-promoting activity. isolated from the most active ethyl acetate soluble fraction on Caenorhabditis elegans (C. elegans).
Injection of 6 gingerol elevated the survival rate of worms against stressful environments including thermal, osmotic, and oxidative conditions.
The bioactive compound elevated the antioxidant enzyme activities of C. elegans and showed a dose-depend reduction of intracellular reactive oxygen species (ROS) accumulation in worms.
Furthermore, 6 gingerols also demonstrated increased stress tolerance, leading to the promotion of stress resistance proteins.
The findings strongly suggest that 6-gingerol exerted longevity-promoting activities independently of these factors and could extend the human lifespan.
Taken altogether, ginger and shell ginger may be considered functional foods for the promotion of healthy longevity with no side effects, pending the confirmation of a large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals' Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) Longevity and Stress Resistant Property of 6-Gingerol from Zingiber officinale Roscoe in Caenorhabditis elegans by Eun Byeol Lee,1 Jun Hyeong Kim,1 Chang Wan An,1 Yeong Jee Kim,1 Yun Jeong Noh,1Su Jin Kim,1 Ju-Eun Kim,1 Abinash Chandra Shrestha,1 Ha-Neul Ham,1 Jae-Yoon Leem,1Hyung-Kwon Jo,2 Dae-Sung Kim,2 Kwang Hyun Moon,3 Jeong Ho Lee,3 Kyung Ok Jeong,3 andDae Keun Kim. (PubMed)
(2) Viewpoint: A Contributory Role of Shell Ginger (Alpinia zerumbet) for Human Longevity in Okinawa, Japan? by Rolf Teschke1,* and Tran Dang Xuan. (PMC)
(3) The Population Health Benefits Of A Healthy Lifestyle: Life Expectancy Increased And Onset Of Disability Delayed by Mehta N1, Myrskylä M. (PubMed)
(4) Exercise and longevity by Vincent Gremeaux, Duxabcdef, MathieuGay, RomualdLeperse, Philippe Sosneraghi, MartinJuneau, AnilNigam. (Science Direct)
Tuesday, January 10, 2023
Fennel Balances the Ratio of the Levels Free Radicals and Antioxidants in Our Body, Researchers Find
Imbalancing the ratio of the free radicals and antioxidants in the facilitation of oxidative stress was associated with the increased risk of the early onset of many chronic diseases, scientists found.
Fennel is a species of Foeniculum Vulgare, belonging to the family Apiaceae (Umbelliferae), and native to the shores of the Mediterranean, may process a potential effect in improving the levels of antioxidant enzymes produced by the human body, therefore, adding a portion of fennel on your daily diet should be helpful in reducing the risk of diabetics, rheumatoid arthritis, post-ischemic perfusion injury, myocardial infarction, cardiovascular diseases, chronic inflammation, stroke ...
Dr. Moylan JS, the lead author in the study "Oxidative stress, chronic disease, and muscle wasting", wrote, "If an overproduction of oxidants overwhelms the antioxidant defenses, oxidative damage of cells, tissues, and organs ensue. In some cases, oxidative stress is assigned a causal role in disease pathogenesis, whereas in others the link is less certain".
Free radicals are unstable molecules with unpaired electrons produced daily in our body, reactive oxygen species, and reactive nitrogen can induce a domino's effect by stealing an electron from other molecules, leading to a continued function that cannot stop until they are paired or inhibited by the presence of antioxidant molecules.
If the generation of free radicals exceeds the protective effects of antioxidants and some co-factors, the process can cause oxidative damage accumulated during the life cycle, leading to the disruption in the function of the cells.
There are many risk factors that can increase the overexpression of free radicals, including fried foods, alcohol, tobacco smoke, pesticides, and air pollutants.
Therefore by changing your diet pattern with more fruits and vegetables, whole grains, and less red meat and processed foods and maintaining an active lifestyle, you can absolutely balance the ratio of free radicals and antioxidants in your body, thus decreasing the risk of many related chronic diseases.
In the review of the traditional use of fennel essential oils (EO) possess antimicrobial, anti-inflammable oil and insect repellent, anti-cancer, and antioxidant properties, researchers launched a comparison of essential oil and their main constituents in Citrus aurantium, C. limon, Cupressus sempervirens, Eucalyptus globulus, Foeniculum vulgare, and Thymus vulgaris.
EO of fennel showed the best free radicals scavenging capacity compared to others.
Fennel EO also was most effective against lipid peroxidation along with EO of C. limon.
Interestingly, after in-depth analysis, researchers discovered the antioxidant and anti-inflammatory activities of the EOs were plant-species-dependent and not always attributable to the EOs main components.
Additionally, in the evaluation of chemical constituents from essential oil from (Foeniculum vulgare var. azoricum, Foeniculum vulgare var. dulce, and Foeniculum vulgare var. Vulgare, researchers suggested
* trans-Anethole, estragole, fenchone and limonene found highly abundant in all of the examined oils demonstrated strong antioxidant activities in the DPPH radical scavenging, lipid peroxidation, and metal chelating assays
* All 3 tested essentials display significant antimicrobial activities against two species of fungi, two species of Gram-negative, and two species of Gram-positive bacteria.
Finally, in the study to assess the efficacy of medicinal plants used traditionally in folk medicine as natural healing remedies with therapeutic effects such as prevention of cardiovascular diseases, inflammation disorders, or reducing the risk of cancer, researchers found that fennel in comparison to other medical exerts a strong antioxidant effect through many of its bioactive compound such as phenolic compounds.
However, Dr. Škrovánková S, the lead scientist in the concerns of some conditions that may affect the herbal quality, said, "The antioxidant properties of medicinal plants depend on the plant, its variety, environmental conditions, climatic and seasonal variations, geographical regions of growth, degree of ripeness, growing practices, and many other factors such as postharvest treatment and processing.
Taken all together, adding a portion of fennel into your diet may have a potential effect in increasing the levels of antioxidants in your body and countering the risk of overexpression of free radicals.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals' Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Anti-oxidant, anti-inflammatory and anti-proliferative activities of Moroccan commercial essential oils by Aazza S, Lyoussi B, Megías C, Cortés-Giraldo I, Vioque J, Figueiredo AC, Miguel MG. (PubMed)
(4) Distillation time modifies essential oil yield, composition, and antioxidant capacity of fennel (Foeniculum vulgare Mill) by Zheljazkov VD1, Horgan T, Astatkie T, Schlegel V.(PubMed)
(3) Antioxidant activity and protecting health effects of common medicinal plants.
(4) Oxidative stress, chronic disease, and muscle wasting by Moylan JS1, Reid M. (PubMed)
Fennel is a species of Foeniculum Vulgare, belonging to the family Apiaceae (Umbelliferae), and native to the shores of the Mediterranean, may process a potential effect in improving the levels of antioxidant enzymes produced by the human body, therefore, adding a portion of fennel on your daily diet should be helpful in reducing the risk of diabetics, rheumatoid arthritis, post-ischemic perfusion injury, myocardial infarction, cardiovascular diseases, chronic inflammation, stroke ...
Dr. Moylan JS, the lead author in the study "Oxidative stress, chronic disease, and muscle wasting", wrote, "If an overproduction of oxidants overwhelms the antioxidant defenses, oxidative damage of cells, tissues, and organs ensue. In some cases, oxidative stress is assigned a causal role in disease pathogenesis, whereas in others the link is less certain".
Free radicals are unstable molecules with unpaired electrons produced daily in our body, reactive oxygen species, and reactive nitrogen can induce a domino's effect by stealing an electron from other molecules, leading to a continued function that cannot stop until they are paired or inhibited by the presence of antioxidant molecules.
If the generation of free radicals exceeds the protective effects of antioxidants and some co-factors, the process can cause oxidative damage accumulated during the life cycle, leading to the disruption in the function of the cells.
There are many risk factors that can increase the overexpression of free radicals, including fried foods, alcohol, tobacco smoke, pesticides, and air pollutants.
Therefore by changing your diet pattern with more fruits and vegetables, whole grains, and less red meat and processed foods and maintaining an active lifestyle, you can absolutely balance the ratio of free radicals and antioxidants in your body, thus decreasing the risk of many related chronic diseases.
In the review of the traditional use of fennel essential oils (EO) possess antimicrobial, anti-inflammable oil and insect repellent, anti-cancer, and antioxidant properties, researchers launched a comparison of essential oil and their main constituents in Citrus aurantium, C. limon, Cupressus sempervirens, Eucalyptus globulus, Foeniculum vulgare, and Thymus vulgaris.
EO of fennel showed the best free radicals scavenging capacity compared to others.
Fennel EO also was most effective against lipid peroxidation along with EO of C. limon.
Interestingly, after in-depth analysis, researchers discovered the antioxidant and anti-inflammatory activities of the EOs were plant-species-dependent and not always attributable to the EOs main components.
Additionally, in the evaluation of chemical constituents from essential oil from (Foeniculum vulgare var. azoricum, Foeniculum vulgare var. dulce, and Foeniculum vulgare var. Vulgare, researchers suggested
* trans-Anethole, estragole, fenchone and limonene found highly abundant in all of the examined oils demonstrated strong antioxidant activities in the DPPH radical scavenging, lipid peroxidation, and metal chelating assays
* All 3 tested essentials display significant antimicrobial activities against two species of fungi, two species of Gram-negative, and two species of Gram-positive bacteria.
Finally, in the study to assess the efficacy of medicinal plants used traditionally in folk medicine as natural healing remedies with therapeutic effects such as prevention of cardiovascular diseases, inflammation disorders, or reducing the risk of cancer, researchers found that fennel in comparison to other medical exerts a strong antioxidant effect through many of its bioactive compound such as phenolic compounds.
However, Dr. Škrovánková S, the lead scientist in the concerns of some conditions that may affect the herbal quality, said, "The antioxidant properties of medicinal plants depend on the plant, its variety, environmental conditions, climatic and seasonal variations, geographical regions of growth, degree of ripeness, growing practices, and many other factors such as postharvest treatment and processing.
Taken all together, adding a portion of fennel into your diet may have a potential effect in increasing the levels of antioxidants in your body and countering the risk of overexpression of free radicals.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals' Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Anti-oxidant, anti-inflammatory and anti-proliferative activities of Moroccan commercial essential oils by Aazza S, Lyoussi B, Megías C, Cortés-Giraldo I, Vioque J, Figueiredo AC, Miguel MG. (PubMed)
(4) Distillation time modifies essential oil yield, composition, and antioxidant capacity of fennel (Foeniculum vulgare Mill) by Zheljazkov VD1, Horgan T, Astatkie T, Schlegel V.(PubMed)
(3) Antioxidant activity and protecting health effects of common medicinal plants.
(4) Oxidative stress, chronic disease, and muscle wasting by Moylan JS1, Reid M. (PubMed)
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