Tocopherols Reduce the Risk and Progression of Prostate Cancer in Vivo

The prostate gland wrapped around around a tube (the urethra), is a gland of the male reproductive system found in front of the rectum and just below the bladder.
The prostate gland is a gland that makes and stores semen. It is located below the bladder and surrounds the tube that carries urine out of your body.

Additionally, the muscles of the prostate gland also play a critical role in propelling seminal fluid into the urethra during ejaculation

Symptoms of an enlarged prostate are associated with a natural impend the conversion of testosterone to DHT. Unfortunately, aging is not the only cause of enlarged prostate.

Prostate cancer is a medical and chronic condition caused by the growth of cells irregularly in the tissue of the prostate.

Most cases of prostate cancer start in the cells on the surface of the inner lining of the prostate gland.
According to the statistic provided by the Canadian Cancer Society, prostate cancer is the third most common cancer among Canadian men and the 3rd leading cause of death from cancer in men in Canada.

In 2017, approximately 21,300 men were diagnosed with prostate cancer, accounting for 21% of all new cancer cases in men.

Furthermore, approximately 1 in 7 Canadian men will develop prostate cancer during his lifetime and 1 in 29 will die from it.

The 5-year survival rate for most men with local or regional prostate cancer is nearly 100%.

In other words, For men diagnosed with prostate cancer that has not spread to other parts of the body, the 5-year survival rate is 100%.


However, the 5 years survival rate of prostate cancer that has spread to other parts of the body, is only 30%.

Tocopherols are phytochemicals of which many have vitamin E activity, belonging to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, and seed or nut oils, etc.

On finding a potential phytochemical for the treatment of chronic diseases, researchers examined the effect of tocopherols on prostate cancer.

The study included specific Pten-/- (Ptenp-/-) mice induced cancer by activation of AKT cancer promotion signaling, fed by Ptenp-/- mice with AIN93M or 0.2% δ-T supplemented diet, at the age of 6 or 12 weeks.According to the analysis,
* δ-T treatment reduced prostate adenocarcinoma multiplicity at the age of 40 weeks by 53.3 and 42.7%, respectively.

* Furthermore, the phosphorylation of AKT (T308) that promotes cancer growth and survival was reduced in the prostate of the mice administered the δ-T diet.

* δ-T diet also, reduced proliferation and increased apoptosis in the prostate cancer cell line without affecting the oxidative stress.

Interestingly, α-tocopherol (α-T) at 0.2% in the diet exhibited anti-prostate cancer cell activity with no effects on prostate adenocarcinoma multiplicity in the Ptenp-/- mice.


After taking other factors into account, researchers said, " δ-T inhibits the development of prostate adenocarcinoma in Ptenp-/- mice, mainly through inhibition of AKT activation".

Taken together, tocopherols may be considered an adjunct therapy in the treatment of prostate cancer, pending the confirmation of the larger sample size and multicenter human study.

Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.Norton's


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the prostate-specificinternational journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Carotenoids, retinol, tocopherols, and prostate cancer risk: a pooled analysis of 15 studies by Key TJ1, Appleby PN2, Travis RC2, Albanes D3, Alberg AJ4, Barricarte A5, Black A3, Boeing H6, Bueno-de-Mesquita HB7, Chan JM8, Chen C9, Cook MB3, Donovan JL10, Galan P11, Gilbert R10, Giles GG12, Giovannucci E13, Goodman GE14, Goodman PJ15, Gunter MJ16, Hamdy FC17, Heliövaara M18, Helzlsouer KJ19, Henderson BE20, Hercberg S11, Hoffman-Bolton J21, Hoover RN3, Johansson M22, Khaw KT23, King IB24, Knekt P18, Kolonel LN25, Le Marchand L25, Männistö S18, Martin RM26, Meyer HE27, Mondul AM3, Moy KA3, Neal DE28, Neuhouser ML29, Palli D30, Platz EA31, Pouchieu C12, Rissanen H18, Schenk JM32, Severi G12, Stampfer MJ13, Tjønneland A33, Touvier M11, Trichopoulou A34, Weinstein SJ3, Ziegler RG3, Zhou CK3, Allen NE35; Endogenous Hormones Nutritional Biomarkers Prostate Cancer Collaborative Group. (PubMed)
(2) δ-Tocopherol inhibits the development of prostate adenocarcinoma in prostate specific Pten-/- mice by Wang H1, Yang X1, Liu A1, Wang G2, Bosland MC3, Yang CS. (PubMed)