Medical Advisor Journals

Monday, October 5, 2015

The effects of Phytochemicals against Bowel Cancer By Kyle J. Norton

Phytochemials are defined as a group of chemical compound found naturally in plants, including fruits, vegetables, beans, grains, etc.
Cancer is a class of diseases in which a group of cells growing and multiplying disordered and uncontrollable way in our body, have become progressively worse and damaged other healthy tissues, sometimes spreads to other organs in the body via lymph or blood and results in death.
Food intake can help to prevent and treat cancers. Many studies have proven that they can because of certain phytochemicals, but for what ever reason, there are either no clinical trials follow through or the studies can not make to stage of clinical trials. Do not expect the pharmateutical or foods industrial companies to pay for the researches, as the discovery of the phytochemicals to cure cancers can only dampen the profits of both industries as phytochemicals can not be patented.
I. Bowel Cancer (Colon and rectum)
Bowel cancer also known as colorectal cancer, is defined as a condition of the abnormal proliferation of cells in the colon, rectum, or vermiform appendix. Bowl is divided in 2 parts, the first part of the bowel, the small bowl, is involved with the digestion and absorption of food. The 2nd part, the large bowel which consist the the colon and rectum, is involved in absorption of water from the small bowel contents and broken down of certain materials in the feces into substances of which some of them to be re absorbed and reused by the body. Bowel cancer is relatively very common and slowly growing and progress cancer and in predictable way.
Bowel cancer is the third most commonly diagnosed cancer in developed countries, including U>S and Canada.

II. Types of bowel cancer
1. Adenocarcinomas
Most bowel cancers are adenocarcinomas, originated in epithelium tissues, including the surface layer of skin, glands and their tissues that line the cavities and organs of the body.

2. Squamous cell cancers
Squamous cells are the skin like cells that make up the bowel lining together with the gland cells. Squamous cell cancers are rare with the risk of 25 per 100000.

Other bowel tumours
3. Carcinoid
Carcinoid is an unusual type of slow growth neuroendocrine tumor. It looks benign but might spread to other parts of the body as they grow in hormone producing tissue in the digestive system.

4. Leiomyosarcomas
Leiomyosarcomas are the rare and resistant types of bowel cancer and generally not very responsive to chemotherapy or radiation. They are malignant abnormal mass of tissue of smooth muscles of colon, comprising between 5–10% of soft tissue sarcomas.

5. Lymphomas
Bowel lymphomas are rare and more likely to start in the rectum rather in the colon. Many patients with lymphomas are diagnosed in the late stage and already spread to other organs.

6. Melanomas
Melanomas are rare malignant tumor of cells that produce the dark pigment. This type of bowel cancer usually originates from somewhere else and then spread to the bowel.

7. Etc.

III. Types of Food to Prevent and Treat Bowel Cancer (Colon and rectum)
1. Coffee
Epidemiological studies suggest that coffee consumption reduces the risk of cancers, including colon cancer, but the molecular mechanisms and target(s) underlying the chemopreventive effects of coffee and its active ingredient(s) remain unknown. Dr. Kang NJ
, and scientists in the University of Minnesota, found that Coffee or caffeic acid (CaA) strongly suppressed mitogen-activated MEK1 and TOPK activities and bound directly to either MEK1 or TOPK in an ATP-noncompetitive manner. Coffee or CaA, but not caffeine, inhibited ERKs phosphorylation, AP-1 and NF-κB transactivation and subsequently inhibited TPA-, EGF- and H-Ras-induced neoplastic transformation of JB6 P+ cells. Coffee consumption was also associated with a significant attenuation of ERKs phosphorylation in colon cancer patients(1).

2. Green tea
pigallocatechin-3-gallate (EGCG), a major polyphenolic constituent in greentea has been exerted protective effects against proliferation and migration of the human colon cancer SW620 cells. In the study of Epigallocatechin-3-gallate inhibits proliferation and migration of human colon cancer SW620 cells in vitro found that EGCG blocks the proliferation and migration of SW620 cells induced by PAR2-AP and factor VIIa via inhibition of the ERK1/2 and NF-κB pathways. The compound may serve as a preventive and therapeutic agent for colon cancers(2).

3. Extra-virgin olive oil
"EVOO-derived complex phenols (especially from the Arbequina variety olive) have been shown to suppress cell growth of SW480 and HT29 human colonadenocarcinoma cell lines. Inhibition of proliferation by EVOO-PE Arbequina variety extract was accompanied by apoptosis in both colon-cancer-cell lines and a limited G₂M cell-cycle arrest in the case of SW480 cells" said Dr. v and the research team at the University of Granada(3).

4. Wheat bran
Phytic acid (PA) found abundantly in Wheat bran is a natural antioxidant and may have numerous health benefits. Dr. Khatiwada J, and the research team at the North Carolina A&T State University, Kannapolis, indicated that This experiment was designed to investigate the inhibitory effects of combinations of 1% and 2% GT, PA, and inositol (I) in reducing the incidence of azoxymethane-induced colon tumors in Fisher 344 male rats. After an acclimatization period of 1 week, nine groups of rats (15 rats per group) were initially assigned to consume AIN 93 G diet and later AIN 93 M diet after 20 weeks of age. Treatments were given in drinking water. All rats received azoxymethane injections (16 mg/kg of body weight) subcutaneously at 7 and 8 weeks of age. Rats were killed at 45 weeks of age by CO(2) euthanasia. Tumor incidence (93.76%) and the number of tumors per tumor-bearing rat ratio (2.25) were significantly (P<.05) higher in the control group compared with treatment groups. Glutathione S-transferase activity was significantly (P<.05) higher in rats fed combinations of 2% GT+PA+I and GT+PA (33.25 ± 1.23 and 29.83 ± 1.10 μmol/mL, respectively) compared with other groups(4).

5. Berries
Dr. Brown EM and the research team at the University of Ulste, in the study of Mechanisms underlying the anti-proliferative effects of berry components in in vitro models of colon cancer, said "Berries are a common element of Western diets, with members of the Rubus, Fragria, Sorbus, Ribes and Vaccinum genus featuring in desserts, preserves, yoghurts and juices. These soft fruit are rich in bioactive phytochemicals including several classes of phenolic compounds such as flavonoids (anthocyanins, flavonols and flavanols) and phenolic acids (hydroxybenzoic and hydroxycinnamic acids). Whilst there is little data linking berry consumption to reduced risk of colorectal cancer, in vitro evidence from models representing colorectal cancer suggests that berry polyphenols may modulate cellular processes essential for cancer cell survival, such as proliferation and apoptosis"(5).

6. Etc.

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Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/21317303
(2) http://www.ncbi.nlm.nih.gov/pubmed/22101170
(3) http://www.ncbi.nlm.nih.gov/pubmed/22365054
(4) http://www.ncbi.nlm.nih.gov/pubmed/21501094
(5) http://www.ncbi.nlm.nih.gov/pubmed/21466426

Sunday, October 4, 2015

The effects of Phytochemicals against Cancer of Esophagus/Esophageal cancer By Kyle J. Norton

Back to Phytochemicals and Cancers and Diseases http://kylejnorton.blogspot.ca/p/blog-page_18.html
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Please follow me at http://twitter.com/kylejnorton
Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/20232121
(2) http://www.ncbi.nlm.nih.gov/pubmed/15203378
(3) http://www.ncbi.nlm.nih.gov/pubmed/12963477
(4) http://www.ncbi.nlm.nih.gov/pubmed/8182766
(5) http://www.ncbi.nlm.nih.gov/pubmed/19398904

Saturday, October 3, 2015

Munchable Snack Mix

Recipe contributed by Quick and easy family favorites by Vickie and JoAnn

This sweet and salty mix is ideal to take along in a road trip. It's a snack that will appeal to savory and sweet lovers alike
2(12-oz.) pkgs. candy-coated chocolate mini baking bits
12-oz. can salted peanuts
11-oz. pkg. butterscotch chips
2. c. raisins
1. cashews

Combined all ingredients in a large mixing bowl, mix well. Place in plastic zipping bags.
Make 9 cups.

Coralita Truax
Loudonville, OH

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Using Holistic Ancient Chinese Medicine

The effects of Phytochemicals against Brain and Spinal Cord Cancer By Kyle J. Norton

Phytochemials are defined as a group of chemical compound found naturally in plants, including fruits, vegetables, beans, grains, etc.
Cancer is a class of diseases in which a group of cells growing and multiplying disordered and uncontrollable way in our body, have become progressively worse and damaged other healthy tissues, sometimes spreads to other organs in the body via lymph or blood and results in death.
Food intake can help to prevent and treat cancers. Many studies have proven that they can because of certain phytochemicals, but for what ever reason, there are either no clinical trials follow through or the studies can not make to stage of clinical trials. Do not expect the pharmateutical or foods industrial companies to pay for the researches, as the discovery of the phytochemicals to cure cancers can only dampen the profits of both industries as phytochemicals can not be patented.
III. Brain and Spinal Cord Cancer
A. Brain and spinal cord make up the nervous system. Brain and Spinal Cord tumors originating is not very common. Most primary tumors are caused by abnormal cells growth that surround and support neurons, with a small number may be caused by gene defect from exposure to radiation or toxic chemicals. Benign tumors are noncancerous, and malignant tumors are cancerous. More than 190.000 people in US are diagnosed with a brain tumor each year alone.

B. Types of brains and spinal cord cancer
1. Non-infiltrating astrocytomas
Noninfiltrating astrocytomas are tumors that grow slowly and usually do not grow into the tissues around them and is considered as benign tumors.
a. Juvenile pilocytic astrocytomas
Juvenile pilocytic astrocytomas occur most often in the cerebellum in young children and is a neoplasm of the brain that occurs more often in children and young adults (in the first 20 years of life).
b. Subependymal giant cell astrocytomas
Subependymal giant cell astrocytomas grow in the ventricles and are almost always seen in children with tuberous sclerosis, but it can can become aggressive and cause obstructive hydrocephalus usually in older children and adolescents.

2. Low-grade astrocytomas (Infiltrating or diffuse astrocytomas)
An astrocytoma is a type of glioma that develops from star-shaped cells (astrocytes) that support nerve cells and accounts for about 10 percent to 15 percent of gliomas, a primary brain tumor that originates from the supportive cells of the brain. Low-grade astrocytomas is classified as a grade II tumor.

3. Intermediate- and high-grade astrocytomas
a. Intermediate- grade astrocytomas
Intermediate-grade astrocytomas (grade III) have more anaplasia and readily detectable mitotic activity, but not necrosis. The white arrow points to a mitotic figure. Glioblastomas, which are the most malignant grade of astrocytoma, are highly anaplastic and contain mitotic activity and tumour necrosis.
b. High-grade astrocytomas
High-grade astrocytomas are very different from secondary brain tumors, which originally developed elsewhere in the body and spread (metastasized) to the brain and generally respond poorly to surgery, radiation therapy, and chemotherapy.

4. Oligodendrogliomas and anaplastic oligodendrogliomas
a. Anaplastic astrocytomas
Malignant or anaplastic astrocytoma is a glioma that develops from star-shaped glial cells (astrocytes) that support nerve cells. It is an infiltrating, primary brain tumor, with tentacles that may invade surrounding tissue and is classified as more aggressive grade III astrocytomas.
b. Glioblastomas
Glioblastomas is the most common and most aggressive malignant primary brain tumor in humans, involving glial cells and accounting for 52% of all parenchymal brain tumor cases and 20% of all intracranial tumors and is and is classified as more aggressive grade IV astrocytomas.

5. Ependymomas and anaplastic ependymomas
a. Ependymomas
Ependymoma is malignant glioma originated in ependyma, a tissue of the central nervous system. Usually, in children the location is intracranial, while in adults it is spinal. The common location of intracranial ependymoma is the fourth ventricle. Rarely, ependymoma can occur in the pelvic cavity.

6. Anaplastic ependymomas
Anaplastic ependymoma is a malignant tumor of ependymomas, a tissue of the central nervous systemcommonly found in children and adults that are younger than 25 years old. These tumors grow rapidly and most patient eventually die if the tumor is not diagnosed and treated early.

7. Schwannomas (including acoustic neuromas)
Schwannomas is a noncancerous nerve sheath tumor arises from the nerve sheath and consisted of Schwann cells in a collagenous matrix, which normally produce the protective covering to peripheral nerves. As it grows, it can cause pressure, irritation or damage to the nerve and affect the sensations of hearing and balance.

8. Spinal cord tumors
Primary cancerous tumors of spinal cord are not common. Most of spinal cord tumors are secondary tumors, and are spread from other parts of the body but they can interfere with the transmitting signals from the brain to the spinal cord, leading to loss of function and sensation.

9. Lymphomas
Lymphomas is a cancer in the lymphatic cells of the immune system, including Hodgkin disease and non-Hodgkin lymphoma.
a. Hodgkin disease
Hodgkin disease is a type of lymphoma found in the lymph nodes, named after Thomas Hodgkin who published the first description of lymphoma in 1832 and can spread systemically from one lymph node group to another.
b. Non-Hodgkin lymphoma
Non-Hodgkin lymphomas are caused by abnormal growth of cancerous white blood cells (T and B cells) due to mutation or alternation of cells DNA. They can spread to almost any other part of the body.

10. Brain tumors that occur more often in children
a. Astrocytomas
Astrocytomas in children age from 5 -8 age are usually benign, low grade which are localized and grow slowly.
b. Ependymomas
Ependymomas arises from cells of the ependymal lining located in tiny passageways (ventricles) in the brain and interfered with the flow of cerebrospinal fluid (CSF), causing problem of speak, walk, eat, see and other normal functions in children.

c. Medulloblastomas
Medulloblastomas are the most common types of brain cancers in children originated in the cerebellum (10-20%) or posterior fossa (40%) and occurred more often in boys than girls between age 5 to 10.

11. Etc.

C. Types of Food to Prevent and Treat Brain and Spinal Cord Cancer
1, Green tea
Epigallocatechin-gallate (EGCG), a main ingredients in green tea has shown protective effect against brain cancer. In the study to investigate the effect of epigallocatechin-gallate (EGCG), the main constituent of green teapolyphenols, on human glioblastoma cell lines U-373 MG and U-87 MG, rat glioma cell line C6, and rat nonfunctioning pituitary adenoma cell line MtT/E, showed that EGCG inhibited viability of MtT/E cells only at a concentration of 100 microg/ml. Quantitative study by flow cytometry demonstrated that lower doses of EGCG (12.5, 25, 50 microg/ml) induced apoptosis in U-373 MG, U-87 MG, and C6 cells; however, only the highest dose (100 microg/ml) induced apoptosis in MtT/E cells. Compared with other cell lines, MtT/E cells showed stronger IGF-I immunoreactivity. Neutralization of IGF-I with an antihuman IGF-I antibody reduced viability of the cell lines(1).

2. Mangosteen
γ-mangostin, a phytochemical compound found abundantly in Mangosteen has found to be effective in against Gliomas which is a common type of primary brain tumor with glioblastoma multiforme accounting for the majority of human brain tumors. Dr. Chang HF and the research team at the ollege of Pharmacy, and Center of e-CAM, Taipei Medical University showed that The γ-mangostin showed potent antiproliferative activity toward MGs in dose- and time-dependent manners. In addition, flow cytometric analysis of cell morphology in the apoptotic cells revealed an increase in hypodiploid cells in γ-mangostin treated U87 MG and GBM 8401 cells, while significant enhancement of intracellular peroxide production was detected in the same γ-mangostin treated cells by DCHDA assay and DiOC(6)(3) stain. g-Mangostin induced apoptosis, which in turn mediates cytotoxicity in human MG cells was prevented by the addition of catalase(2).

3. Grapes, red wine, berries and peanuts
Resveratrol is a type of natural phenol found abundantly in Grapes, red wine, berries and peanuts of the group of Stilbenoids, produced naturally by many plants when under attack by bacteria or fungi. It has been studied by many researchers for it health benefits in treating chronic diaereses, including cancer, diabetes, heart disease, etc. Resveratrol is known to have antioxidant, anti-inflammatory and antiproliferative effects on a variety of cancer cells in vitro and in various animal models. However, the effect(s) of resveratrol in vivo on humans are still controversial. This study discusses current knowledge with regard to the effects of resveratrol in relation to its potential as a chemopreventive and/or chemotherapeutic molecule against human gliomas(3).

4. Phytochemical diet(PtcD)
In the study of Glioma induced by ethylnitrosourea to pregnant females fed the diets from the start of gestation until the moment of sacrifice of the offpsrings, found that in male rats fed the PtcD or the BD the incidence of gliomas was markedly reduced compared to rats fed a standard diet (StD). In females this effect was weaker and was limited to the PtcD. A significant proportion of rats with brain tumors and fed the StD exhibited SE evidenced by weight loss, a shorter survival, reduction in liver weight and an increased proportion of liver mitochondria, effects that were not observed in their counterpart fed PtcD. Comparison of the expression of genes involved in the balance proliferation/apoptosis and in the response to oxidative stress in malebrain tumors showed that the prevention of SE was associated with an increase in bcl-2 and catalase and a decrease in ki-67, sod-1 and sod-2 transcripts(4)

5. Dietary antioxidants
Dr, Sheweita SA and Dr. Sheikh BY. at the Alexandria University, Egypt in the study of Can dietary antioxidants reduce the incidence of brain tumors?, showed that dietary supplementation with antioxidants [e.g. vitamins C & E] was found to reduce the incidence of brain tumors in children whose mothers took these vitamins throughout pregnancy. On the other hand, decreases in antioxidant levels were correlated with the severity of malignancy of braintumors, and also with accumulation of considerable amounts of oxidative stress products including free radicals which damage this tissue. The mechanisms of protection of these antioxidants against brain tumors might be due to inhibition of the nitrosation process, decreasing of tumor necrotic factor, scavenging of free radicals, inhibition of telomerase activity which facilitates telomere attrition(5)

6. Beans
In the study to investigate potential associations between diet and adult glioma with a population-based case-control study of adult glioma in eastern Nebraska. Nutrient and food group intakes were estimated for 236 glioma cases and 449 controls using information obtained from a food-frequency questionnaire, indicated that after adjusting for potential confounders, inverse associations with risk of adult glioma were observed for intakes of dark yellow vegetables (highest quartile versus lowest: OR = 0.6, Ptrend = 0.03) and beans (OR = 0.4, Ptrend = 0.0003), but no associations were seen for dietary sources of preformed nitrosamines or high-nitrate vegetables. Our nutrient analysis revealed significant inverse associations between risk of adult glioma and dietary intake of pro-vitamin A carotenoids (highest quartile versus lowest: OR = 0.5, Ptrend = 0.005), a-carotene (OR = 0.5, Ptrend = 001), beta-carotene (OR = 0.5, Ptrend = 0.01), dietary fiber (OR=0.6, Ptrend = 0.048) and fiber from beans (OR = 0.5, Ptrend = 0.0002). We observed no significant associations with risk of adult glioma for intakes of other nutrients or compounds including nitrate, nitrite, vitamin C, vitamin E, saturated fat, cholesterol, dietary fiber from grain products, or fiber from fruit and vegetables(6).

7. Etc.

Made From Fresh Fruits And Vegetable Recipes
Secret To A Vibrant And Healthy Lifestyle
That You Can Find Easily At The Comfort Of Your Kitchen.

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Pregnancy Miracle
Reverse Infertility And Get Pregnant Naturally
Using Holistic Ancient Chinese Medicine

Back to Phytochemicals and Cancers and Diseases http://kylejnorton.blogspot.ca/p/blog-page_18.html
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Please follow me at http://twitter.com/kylejnorton

Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/11305413
(2) http://www.ncbi.nlm.nih.gov/pubmed/21139533
(3) http://www.ncbi.nlm.nih.gov/pubmed/20010425
(4) http://www.ncbi.nlm.nih.gov/pubmed/18412241
(5) http://www.ncbi.nlm.nih.gov/pubmed/21434862
(6) http://www.ncbi.nlm.nih.gov/pubmed/12296512

Friday, October 2, 2015

Pizza

Recipe contributed by Quick and easy family favorites by Vickie and JoAnn

Offer a pizza buffet line. Put all ingredients in the separate bowls, and let everyone create their own pizza.
8-oz. tube refrigerated crescent rolls
14 -oz. jar pizza sauce
3/4 c. sliced pepperoni
3/4 sliced mushrooms
1 c. shredded mozzarella cheese
Unroll crescent rolls into individual triangles on an ungreased baking sheet. Spread a layer of pizza sauce over dough and top with pepperoni and mushrooms. Sprinkle cheese on top; roll up into crescent shape.
baking at 375 degrees for 18 to 25 minutes or until rolls are golden and cheese is bubbling,
Make 8 appetizers.

Beth Flack
Terre Haute, IN

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Pregnancy Miracle
Reverse Infertility And Get Pregnant Naturally
Using Holistic Ancient Chinese Medicine

The effects of Phytochemicals against Bone Cancer By Kyle J. Norton

Phytochemials are defined as a group of chemical compound found naturally in plants, including fruits, vegetables, beans, grains, etc.
Cancer is a class of diseases in which a group of cells growing and multiplying disordered and uncontrollable way in our body, have become progressively worse and damaged other healthy tissues, sometimes spreads to other organs in the body via lymph or blood and results in death.
Food intake can help to prevent and treat cancers. Many studies have proven that they can because of certain phytochemicals, but for what ever reason, there are either no clinical trials follow through or the studies can not make to stage of clinical trials. Do not expect the pharmateutical or foods industrial companies to pay for the researches, as the discovery of the phytochemicals to cure cancers can only dampen the profits of both industries as phytochemicals can not be patented.
II. Bone cancer
A. A bone cancer is an abnormal growth of cells within the bone that have became cancerous. Bone cancer may be classified as primary canceroriginated in the bone, and secondary cancer originated from elsewhere.

B. Types of bone cancer
B.1. Osteosarcoma(35%)
Osteosarcoma, a cancerous bone tumor, is the most common type of aggressive and primary bone cancer, usually arise in a bone and destroy local tissue and weakens the bone. Since osteosarcoma develops fromosteoblasts, it most commonly affects adolescents and young adult and most cases of osteosarcoma involve the knee joint. It affects about four in one million people in the United States every year.

B.2. Chondrosarcoma(25%)
Chondrosarcoma is a cancer composed of cells derived from transformed cells that produce flexible connective tissues between bones. It is is the second most frequent primary malignant tumor of bone, representing approximately 25% of all primary osseous neoplasms.

B.3. Ewing's sarcoma(16%)
Ewing's sarcoma, a rare cancer disease found in the bone or in soft tissue, is a malignant bone tumor that affects childhood and young adulthood, but usually develops during puberty and spreads to the lungs and other bones.

B.4. Less frequently (≤ 5%) occurring tumors are chordoma, malignant fibrous histiocytoma of bone, and fibrosarcoma of bone.

C. Types of Food to Prevent and Treat Bone Cancer
C.1. Osteosarcoma(35%)
1. Green tea
Dr. Hönicke AS and the research team at University Medicine Greifswald, in the study of The link between cancer and inflammation, found that IL-1Ra and EGCG downregulated IL-1-induced IL-6 and IL-8 release from U-2 OS cells by 65-85%. IL-1Ra and EGCG also reduced secretion of invasiveness-promoting MMP-2 and pro-angiogenic VEGF to 62-75% without affecting the metabolic response and caspase-3 activity. In conclusion, downregulation of IL-1-induced tumorigenic factors (IL-6, IL-8, VEGF, MMP-2) in U-2 OS by IL-1Ra and EGCG may positively affect tumor-associated inflammation and, as a consequence, lead to reduction in angiogenesis and invasiveness. This renders a combined administration of EGCG and IL-1Ra a promising approach as an adjuvant therapy in patients with osteosarcoma(1).

2. Aromatic plants like nutmeg, basil, cinnamon and bay leaves
Eugenol (4-allyl-2-methoxyphenol) found abundantly in aromatic plan has exerted the protective effect against certain types of cancer. Dr. Jaganathan SK and Dr. Supriyanto E., in the study of Antiproliferative and molecular mechanism of eugenol-induced apoptosis in cancer cells, showed that eugenol possesses antioxidant, antimutagenic, antigenotoxic, anti-inflammatory and anticancer properties. Molecular mechanism of eugenol-induced apoptosis in melanoma, skin tumors, osteosarcoma, leukemia, gastric and mast cells(2).

3. Turmeric
Curcumin the main ingredient of turmeric has shown to induce cell apoptosis in human osteosarcoma. Dr. Li Y, and scientists at the Qilu Hospital, Shandong University indicated that curcumin caused marked inhibition ofosteosarcoma cell growth and G2/M phase cell cycle arrest. This was associated with concomitant attenuation of Notch-1 and downregulation of its downstream genes, such as matrix metalloproteinases, resulting in the inhibition of osteosarcoma cell invasion through Matrigel. We also found that specific downregulation of Notch-1 via small-interfering RNA prior to curcumin treatment resulted in enhanced inhibition of cell growth and invasion(3).

4. Etc.

C.2. Chondrosarcoma(25%)
1. Green Tea
Chondrosarcoma is a malignant primary bone tumor that responds poorly to both chemotherapy and radiation therapy. (-)-Epigallocatechin-3-gallate (EGCG), the major polyphenol in green tea, has been shown to inhibit tumorigenesis and cancer cell growth in animal models. In the study conducted by National Chung Hsing University, Dr. Yang WH and research team indicated that EGCG induced cell apoptosis in human chondrosarcoma cell lines but not primary chondrocytes. EGCG induced upregulation of Bax and Bak, downregulation of Bcl-2 and Bcl-XL, and dysfunction of mitochondria in chondrosarcoma and EGCG triggered ROS and activated the ASK1-p38/JNK pathway, resulting chondrosarcoma cell death. Importantly, animal studies revealed a dramatic reduction in tumor volume after 24 days of treatment(4)

2. Turmeric
Turmeric, principal curcuminoid of the popular Indian spice, a rhizomatousherbaceous perennial plant of the ginger family, Zingiberaceae, native totropical South Asia, Curcumin the main ingredient of turmeric has shown to induce cell apoptosis in human chondrosarcoma. Dr. Lee HP, and scientists at the China Medical University Hospital, found that Curcumin induced upregulation of Fas, FasL, and DR5 expression in chondrosarcoma cells. Transfection of cells with Fas, FasL, or DR5 siRNA reduced curcumin-induced cell death. In addition, p53 involved in curcumin-mediated Fas, FasL, and DR5 expression and cell apoptosis in chondrosarcoma cells. Most importantly, animal studies revealed a dramatic 60% reduction in tumor volume after 21days of treatment(5).

3. Etc.

C.3. Ewing's sarcoma(16%)
1. Turmeric
Curcumin is a naturally occurring polyphenolic compound found in theturmeric. Under investigation as a chemotherapeutic and chemopreventive agent in adult cancer models at both pre-clinical and clinical levels. In this preliminary study, showed that curcumin is effective in causing cell cycle arrest, inducing apoptosis, and suppressing colony formation in the Ewing sarcoma cell line SK-NEP-1. Curcumin causes upregulation of cleaved caspase 3 and downregulation of phospho-Akt, producing apoptosis in Ewing sarcoma cells at an inhibitory concentration 50% (IC50) of approximately 4 μM. (6)

2. Green tea
The insulin-like growth factor I receptor (IGFIR) is constitutively activated in Ewing family tumors (EFT) and that the major catechin derivative found ingreen tea, (-)-epigallocatechin gallate (EGCG), can inhibit cell proliferation and survival of EFT cells through the inhibition of IGFIR activity, as treatment of EFT cell lines with EGCG blocked the autophosphorylation of IGFIR tyrosine residues and inhibited its downstream pathways including phosphoinositide 3-kinase-Akt, Ras-Erk, and Jak-Stat cascades. EGCG treatment was associated with dose- and time-dependent inhibition of cellular proliferation, viability, and anchorage-independent growth, as well as with the induction of cell cycle arrest and apoptosis. Apoptosis in EFT cells by EGCG correlated with altered expression of Bcl-2 family proteins, including increased expression of proapoptotic Bax and decreased expression of prosurvival Bcl2, Bcl-XL, and Mcl-1 proteins. Dr. Kang HG and the research team at Children's Hospital Los Angeles suggested(7)

3. Etc.

Made From Fresh Fruits And Vegetable Recipes
Secret To A Vibrant And Healthy Lifestyle
That You Can Find Easily At The Comfort Of Your Kitchen.

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months