Medical Advisor Journals

Monday, December 7, 2015

The Blueberry Smoothie for treatment of Breast Cancer

Kyle J. Norton(Scholar). All right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for people with breast cancer and high risk of the disease

Yield: 2 serving (about 8 ounce each)
1 1/2 cups Blueberries
1 cup rice milk

4-6 ice cubes

1. Place all the ingredients in a blender.
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately.

The dream of finding of a natural ingredient for replacement of serious side effects of chemotherapy for treatment of breast caner has been extremely difficult, probably due to physical differences in testing subjects.

Breast cancer (malignant breast neoplasm) is a cancer originated in the tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma).

In 2010, over 250,000 new cases of breast cancer were diagnosed in women in the U.S. alone and the risk of getting invasive breast cancer during life time of a women is 1/8.

Blueberry, a flower plant, belong to the family Eriaceae and native to Northern America contains several essential phytochemicals and nutrients, including, lutein and zeaxanthin, zinc, potassium, phosphorus, iron, calcium and vitamins.

Blueberry or whole blueberry powder may hold a key for reduced risk breast cancer and for treatment of the diseases. Recent studies insisted that intake of the fruits and the fruit products showed to the improve the survival rate of women with breast cancer.

In estrogen-mediated breast cancer, blueberry-supplemented diet protect women against breast cancer induced by 17β-estradiol (E2)-mediated mammary tumorigenesis(breast cancer)(1) in animals received 5% blueberry diet, either 2 weeks prior to or 12 weeks study.

Dr. Ravoori S and the research team at the University of Louisville suggested, the effectiveness of blue berry for treatment of breast cancer may be a result of the exhibition of its phytochemicals reducing mammary tissue proliferation and tumor burden, tumor latency(2).

In fact the intake of berries reduced significantly mammary tumor incidence (10-30%) by suppressing the levels of E(2) to prevent the early onset of E(2) breast cancer(3).

Dr. Aiyer HS and Gupta RC. said, blueberries and other berries promote anti proliferation and apoptosis of breast cancer cell is due its effects in modulating enzymes of estrogen metabolism.

In breast cancer cell lines MCF7 and MDA-MB-231, pterostilbene, a phytochemical found in blueberries, effectively suppressed tumorigenesis and metastasis of cancer stem cells (CSCs) through reduced expressions in promoted(4) and increased tumor cell proliferation of breast cancer(5).

Addition to that, the joint study lead by the Indian Institute of Technology Roorkee showed that pterostilbene not only expressed itself as a effective inducer of apoptosis in human breast in affecting various cellular targets, it also may be a chemopreventive potential based on its stronger anti-proinflammatory cytokines and anti-inflammatory activities against many forms of diseases(6).

In the study of MCF7, Hs578t and MDA-MB-231 breast cancercell lines, pterostilbene suppressed tumor growth and metastasis in MDA-MB-231, the triple-negative breast cancer and Hs578t cells through inhibition of the migratory and invasive potential by blocking the initiate the metastatic process(7).

Further more, the phytochemical also found to inhibit breast cancer regardless of estrogen receptor (ER-α36 positive or negative breast cancer)status by inducing apoptosis(8) and anti-proliferation(9), with or without the execution of cell death in apoptotic cells(8).

The finding of the effectiveness of blueberry and its phytochemical pterostilbene may serve as a cornerstone of pharmaceutical target for further studies as well as a protential medication for treatment of breast disease.

Women who are at high risk of breast cancer such as genetic mutation genes BRCA1 and BRCA2 should drink at least one cup daily and women with breast cancer should drink the juices as much as they can depending to digestive toleration.

References

(1) Chemopreventive and therapeutic activity of dietary blueberry against estrogen-mediated breast cancer by Jeyabalan J1, Aqil F, Munagala R, Annamalai L, Vadhanam MV, Gupta RC.(PubMed)

(2) Inhibition of estrogen-mediated mammary tumorigenesis by blueberry and black raspberry by Ravoori S1, Vadhanam MV, Aqil F, Gupta RC.(PubMed)

(3) Berries and ellagic acid prevent estrogen-induced mammary tumorigenesis by modulating enzymes of estrogen metabolism by Aiyer HS1, Gupta RC.(PubMed)

(4) Pterostilbene, a bioactive component of blueberries, suppresses the generation of breast cancer stem cells within tumor microenvironment and metastasis via modulating NF-κB/microRNA 448 circuit by Mak KK1, Wu AT, Lee WH, Chang TC, Chiou JF, Wang LS, Wu CH, Huang CY, Shieh YS, Chao TY, Ho CT, Yen GC, Yeh CT.(PubMed)

(5) Twist modulates breast cancer stem cells by transcriptional regulation of CD24 expression by Vesuna F1, Lisok A, Kimble B, Raman V.(PubMed)

(6) Understanding the mode of action of a pterostilbene derivative as anti-inflammatory agent by Nikhil K1, Sharan S1, Palla SR2, Sondhi SM2, Peddinti RK2, Roy P3.(PubMed)

(7) Pterostilbene inhibits triple-negative breast cancer metastasis via inducing microRNA-205 expression and negatively modulates epithelial-to-mesenchymal transition by Su CM1, Lee WH2, Wu AT3, Lin YK4, Wang LS5, Wu CH6, Yeh CT7.(PubMed)

(8) Estrogen receptor-α36 is involved in pterostilbene-induced apoptosis and anti-proliferation in in vitro and in vivobreast cancer by Pan C1, Hu Y2, Li J3, Wang Z4, Huang J5, Zhang S1, Ding L5.(PubMed)

(9) Estrogen receptor-α36 is involved in pterostilbene-induced apoptosis and anti-proliferation in in vitro and in vivobreast cancer by Pan C1, Hu Y2, Li J3, Wang Z4, Huang J5, Zhang S1, Ding L5.(PubMed)

Most Common Diseases of Ages of 50 Plus - Musculoskeletal disorders (MSDs): Cervical Stenosis (with Myleopathy) -The Symptoms, Causes and Risk Factors

Kyle J. Norton(Scholar)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) is medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed(1).

Cervical Stenosis

Cervical Stenosis is defined as a degeneration of the structures of the spine as a result of aging causes of a slowly progressive condition of the cervical spinal cord. Spinal stenosis cause pressure on the spinal cord, which may lead to the symptoms of myelopathy. Cervical spinal stenosis with myelopathy is a common disease in elderly patients of male gender(2).

A. SymptomsSymptoms are as of result of neurologic disease which can lead to progressive disability and eventual paralysis if without appropriate treatment, depending to the expression of the exact distribution of the myelopathy in the spinal cord. Most elders with Cervical Stenosis are experience painless symptoms, others may be experience one of more symptom, depending to the location of the compression and dysfunction of spinal cord.
1. Increased knee and ankle reflex may be a first sign of the disease
2. Tightness of gait and numbness of the legs, depending to the expression of the exact distribution of the myelopathy in the spinal cord of the individual patient, such as weakness, difficulty walking, frequent falls, etc.
3. Pins-and-needles (paraesthesia) sensation in the whole body.
4. Muscle weakness or paralysis
5. Deterioration in fine motor skills (such as handwriting or buttoning a shirt)
6. Intermittent shooting pains into the arms and legs (like an electrical shock), especially when bending their head forward (known as Lermitte’s phenomenon)
7. Arm and neck pain as a result of the myelopathy constitute a combination of cord failure at the affected level and of compression and irritation of the cervical nerve roots which leave the neck at this site, such as weakness, stiffness or clumsiness in the hands,
8. Loss of appreciation of temperature, pain and joint sense and often with impairment of bladder and bowel control, as a result of the transverse lesion of the spinal cord effecting modalities of cord transmission with spasticity of gait and increased tendon reflexes, in the later state of (3).
9. Etc.

B. Causes of risk factors
B.1. Causes
Cervical Stenosis with Myleopathy may be result of degenerative changes within the spine or bone spurs of that can lead to the size of the spinal canal becoming smaller and bone spurs begin to press on the spinal cord or the nerve roots due to related to age, genetics, and wear and tear of daily living. Tumor located between the spinal cord and vertebrae can cause Cervical Stenosis with Myleopathy
B.2. Risk factors
1. Aging and gender
If you are male and over 50 years of age, you are at higher risk to develop Cervical Stenosis with Myleopathy.
2. Genetics
Congenital narrowing of the cervical spinal canal may result in cord compression without a history of injury and occasionally without evidence of significant bony degenerative changes(4).
3. Wear and tear of daily living
Tear and wear, injure can cause scar tissues and weaken the function of disc in absorbing shock, causing pressure on the spinal cord.
4. Injure
Injure to the spine can cause scar tissues which can weaken the spinal tissues, such as thickened ligaments.
5. Etc.

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
References
(1) http://www.ncbi.nlm.nih.gov/pubmed/7864688
(2) http://www.ncbi.nlm.nih.gov/pubmed/22426774
(3)http://www.saspine.org/conditions/cervical_spinal_stenosis_myelopathy.htm
(4) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC492191/

Saturday, December 5, 2015

The Smoothie Recipe of Tangerine peels and Grapes For Lung Cancer

Kyle J. Norton(Scholar)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for people with lung cancer and high risk of the disease

Yield: 2 serving (about 8 ounce each)
1 1/2 cups grapes of any kind with seeds

1 medium tangerine peels
1 cup rice milk

1. Place the grapes, tangerine peels, rice milk, in a blender and puree about 1 minute

2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately

Recent studies suggested that tangerine peels and grape skin and seeds may have a potential effect on treatment of patient with lung cancer.

Lung cancer is defined as a condition of the abnormal growth of the cells in the lung's tissue. Most common form of primary lung cancers are derived from epithelial cells. In Us, Lung cancer is the leading cause of cancer deaths, causing 158,683 people deaths, including 88,329 men and 70,354 women, according to 2007 statistic.

Tangerine, one of the winter fruits found on Chinese New year represent prosperity and good fortune, now has been cultivated all over the world in suitable climate for commercial and health benefits. The peel of the fruit also has been recorded in Chinese herbal medicine over thousand of years for treatment of respiratory diseases, including cough, asthma,.........

Epidemiological study suggested that Tangeretin has long been found to consist the ability in inhibition of apoptosis of human gastric cancer AGS cells through extrinsic and intrinsic signaling pathways (such as P53 antigen and caspase activation).

Tangeretin, a major phytochemicals in tangerine peels, in vitro and in vivo exhibited anti lung cancer effects through induced CL1-5 cell apoptosis and autophagy and inhibited NSCLC cell proliferation, and induce G(2)/M phase arrest and via the mitochondrial apoptotic pathway and autophagy(1)

"By interference of the cancer cell division and destruction of the function of new cell formation in mitochondrial apoptotic pathway involved the The Bcl-2 family of proteins" Kyle J. Norton said " The finding of tangeretin may provide us a natural sources for treatment of lung with little or no adverse effect".

In support of the finding, Dr. Charoensinphon N and the research team at the University of Massachusetts suggested, in comparison of the effects of Tangeretin (TAN) and 5-demethyltangeretin (5DT) on three human nonsmall cell lung cancer (NSCLC) cells, 5DT inhibited NSCLC cell growth by inducing G2/M cell cycle arrest and apoptosismuch stronger than the phytochemical TAN(2).

Other study also insisted that the effectiveness of the phytochemicals for treatment of lung cancer in tangerine peel may be associated to the suppression of inflammation and cell proliferation in the Nuclear factor-κB (NF-κB) family and certain signaling proteins(5).

Grape skin and seeds contains many concentrations, including vitamin E, flavonoids, linoleic acid,oligomeric proanthocyanidins(OPCs), etc..The herb has been used in traditional medicine as antioxidant, anti-inflammatory agents.

Resveratrol, an phytochemical found abundantly in grape seed and skin is a class of Stilbenoids. Epidemiologically, the antioxidant has found effectively for treatment many types of cancer(6) including prostate cancer(7).

Dr. Zhu Y and the research team at the Genomic Medicine Institute, Cleveland Clinic indicated the effects of resveratrol for treatment of non-small cell lung cancer (NSCLC) patients with activating EGFR mutations, probably through induction of cell apoptosis, autophagy, cell cycle arrest and senescence accompanied by increased expression of anti inflammation and proliferation pathways(8).

Analogue of resveratrol, (Z)3,4,5,4'-trans-tetramethoxystilbene (TMS), also inhibited gefitinb-resistant non-small cell lung cancer through inducing apoptosis and autophagy via mediation of calcium signaling pathway(9).

Other studies in support of the above include the joint study lead by the Northeast Ohio Medical University, Rootstown,showed that resveratrol inhibits lung cancer cells, through activation of GADD45α in induction of cancer cell suicide(10). Dr. Sancho M and Dr. Mach N said," The wine polyphenols plays a significant role as antioxidant and prooxidant in cancer, although more extensive studies are required to determine the clinical significance in humans"(11).

" The combination of tangerine and grape smoothie may hold a key to reduce risk for people who are at higher risk of lung cancer as well as for treatment of patient who have already developed the disease" Mr. Kyle J. Norton said, " people with lung cancer in any stage should drink as much as they can depending to the digestive toleration"

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

References

(1) Tangeretin Derivative, 5-Acetyloxy-6,7,8,4'-tetramethoxyflavone Induces G2/M arrest, Apoptosis and Autophagy in Human Non-Small Cell Lung Cancer Cells In vitro and In vivo(PubMed)

Li YR1, Li S2, Ho CT3, Chang YH1, Tan KT1,4, Chung TW5, Wang BY6, Chen YK7, Lin CC1.

(2) 5-demethyltangeretin inhibits human nonsmall cell lung cancer cell growth by inducing G2/M cell cycle arrest and apoptosis by Charoensinphon N1, Qiu P, Dong P, Zheng J, Ngauv P, Cao Y, Li S, Ho CT, Xiao H.(PubMed)

(3) Tangeretin, a citrus polymethoxyflavonoid, induces apoptosis of human gastric cancer AGS cells through extrinsic and intrinsic signaling pathways by Dong Y1, Cao A2, Shi J3, Yin P2, Wang L2, Ji G4, Xie J4, Wu D2.(PubMed)

(4) Tangeretin enhances radiosensitivity and inhibits the radiation-induced epithelial-mesenchymal transition of gastric cancer cells by Zhang X1, Zheng L1, Sun Y1, Wang T2, Wang B3(PubMed)

(5) Tangeretin suppresses IL-1beta-induced cyclooxygenase (COX)-2 expression through inhibition of p38 MAPK, JNK, and AKT activation in human lung carcinoma cells by Chen KH1, Weng MS, Lin JK.(PubMed)

(6) Fighting cancer with red wine? Molecular mechanisms of resveratrol by Kraft TE1, Parisotto D, Schempp C, Efferth T.(PubMed)

(7) Resveratrol regulates the PTEN/AKT pathway through androgen receptor-dependent and -independent mechanisms in prostate cancer cell lines by Wang Y1, Romigh T, He X, Orloff MS, Silverman RH, Heston WD, Eng C.(PubMed)

(8) Resveratrol overcomes gefitinib resistance by increasing the intracellular gefitinib concentration and triggering apoptosis, autophagy and senescence in PC9/G NSCLC cells by Zhu Y1, He W1, Gao X1, Li B1, Mei C1, Xu R1, Chen H1.(PubMed)

(9) (Z)3,4,5,4'-trans-tetramethoxystilbene, a new analogue of resveratrol, inhibits gefitinb-resistant non-small celllung cancer via selectively elevating intracellular calcium level by Fan XX1, Yao XJ1, Xu SW1, Wong VK1, He JX2, Ding J3, Xue WW4, Mujtaba T5, Michelangeli F5, Huang M3, Huang J2, Xiao DK2, Jiang ZB1, Zhou YL1, Kin-Ting Kam R6, Liu L1, Lai-Han Leung E1.(PubMed)

(10) CArG-driven GADD45α activated by resveratrol inhibits lung cancer cells by Shi Q1, Geldenhuys W2, Sutariya V3, Bishayee A4, Patel I5, Bhatia D5.(PubMed)

(11) [Effects of wine polyphenols on cancer prevention].[Article in Spanish] by Sancho M1, Mach N2.(PubMed)

Most Common Diseases of Ages of 50 Plus - Musculoskeletal disorders (MSDs): Fibromyalgia Treatments In Traditional Chinese Medicine perspective

Kyle J. Norton(Scholar)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) is medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed(1).

Fibromyalgia

According to the American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia in the newly proposed criteria for the classification of fibromyalgia are 1) widespread pain in combination with 2) tenderness at 11 or more of the 18 specific tender point sites(a) as a result in responding to pressure.

The Treatment
C. In traditional Chinese medicine perspective
1. Acupuncture
In a study to test the hypothesis that acupuncture improves symptoms of fibromyalgia, researchers at the
Department of Anesthesiology, Mayo Clinic College of Medicine, showed that acupuncture significantly improved symptoms of fibromyalgia. Symptomatic improvement was not restricted to pain relief and was most significant for fatigue and anxiety(39).
2. Combination of acupuncture and cupping therapy
A combination of acupuncture and cupping therapy was better than conventional medications for reducing pain (MD, -1.66; 95% CI, -2.14 to -1.19; p < 0.00001; I(2) = 0%), and for improving depression scores with related to FM (MD, -4.92; 95% CI, -6.49 to -3.34; p < 0.00001; I(2) = 32%). Other individual trials demonstrated positive effects of Chinese herbal medicine on pain reduction compared with conventional medications. There were no serious adverse effects reported that were related to TCM therapies in these trials, according to the study by The Centre for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine(40).
2. Chinese herbal formulas
In a study of differentiation of Two TCM practitioners conducted baseline TCM diagnostic examinations on 56 women with FM, found that three primary TCM diagnoses were found in the population: Qi and Blood Deficiency(46.4%, CI 33.0% to 60.36%), Qi and Blood Stagnation (26.8%, CI 15.8% to 40.3%), and Liver Qi Stagnation (19.6%, CI 10.2% to 32.4%). Other study showed that syndromes were found to be important in FS include : 1)liver-Qi-stagnation 2) Yin and blood deficiency of the liver, 3) Yang-weakness of the spleen and kidney, 4) Yin-weakness of the kidney(41).
Dr. Shen in the article of Chinese Herbs & Chinese Medicine for Fibromyalgia, suggested the below formula to relieve pain
bai shao – 20%, qin jiao – 10%, du huo – 10%, yan hu sou – 10%, yu jin – 10%, tao ren – 10%, hong hua – 10%, mu dan pi – 10%, da zao – 5%, gan cao – 5%,
Basic Pain Formula; Take 3-4 grams (scoops), 3 times a day mixed with liquid or food.
Preferably on an empty stomach. (Should not be taken by pregnant women)(42).

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 MonthsBack to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(39) http://www.ncbi.nlm.nih.gov/pubmed/16770975
(40) http://www.ncbi.nlm.nih.gov/pubmed/20423209
(41) http://www.ncbi.nlm.nih.gov/pubmed/22026964
(42) http://www.drshen.com/herbsforfibromyalgia.htm

Friday, December 4, 2015

Most Common Diseases of Ages of 50 Plus - Musculoskeletal disorders (MSDs): Fibromyalgia Treatments In Herbal medicine perspective

Kyle J. Norton(Scholar)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) is medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed(1).

Fibromyalgia

According to the American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia in the newly proposed criteria for the classification of fibromyalgia are 1) widespread pain in combination with 2) tenderness at 11 or more of the 18 specific tender point sites(a) as a result in responding to pressure.

The Treatment
B. In Herbal medicine perspective
In the measurement of the prevalence of NHP use among adults in Canada, identify the most commonly used agents, and determine the socioeconomic, demographic, and health-related correlates of use, showed that Glucosamine, echinacea, and garlic were the most frequently used products. Women reported NHP use more frequently than men (11.5% vs. 7.1%). As compared to young adults, NHP use was about 50% higher in middle-aged and older Canadians. There were no associations with either income or education level. Several disease states were associated with a high prevalence of NHP use: respondents with fibromyalgia (23.3%), inflammatory bowel disease (17.4%), and urinary incontinence (16.8%) were most likely to be NHP users(35).
1. Ginkgo biloba
In an open, uncontrolled study was undertaken to measure the subjective effects of coenzyme Q10 combined with a Ginkgo biloba extract in volunteer subjects with clinically diagnosed fibromyalgia syndrome, researchers found that a progressive improvement in the quality-of-life scores was observed over the study period and at the end, the scores showed a significant difference from those at the start. This was matched by an improvement in self-rating with 64% claiming to be better and only 9% claiming to feel worse. Adverse effects were minor(36).
2. Harpagophytum procumbens (Devil’s claw), Salix alba (White willow bark), and Capsicum frutescens (Cayenne)
In a systematic review of randomized controlled trials to determine the effectiveness of herbal medicine compared with placebo, no intervention, or “standard/accepted/conventional treatments” for nonspecific low back pain, found that Harpagophytum procumbens (Devil’s claw), Salix alba (White willow bark), and Capsicum frutescens (Cayenne) seem to reduce pain more than placebo. Additional trials testing these herbal medicines against standard treatments will clarify their equivalence in terms of efficacy(37).
3. Cayenne is also known as Cayenne Pepper, a red, hot chili pepper, belonging to Capsicum annuum, the family Solanaceae, native to sub-tropical and tropical regions. It has been used in traditional medicine to increases metabolism, enhance circulatory system and stomach and the intestinal tract, adjust blood pressure, lower LDL cholesterol and triglycerides, treat frostbite, muscles, arthritis, rheumatism, low back pain, strains, sprains, bruises and neuralgia, etc.
the non-pungent pepper CH-19 Sweet and of hot red pepper activates the sympathetic nervous system (SNS) and enhances thermogenesis as effectively as hot red pepper, ant that the heat loss effect due to CH-19 Sweet is weaker than that due to hot red pepper. Furthermore, we found that intake of CH-19 Sweet does not affect systolic BP or HR, while hot red pepper transiently elevates them, according to the study of “Effects of CH-19 Sweet, a non-pungent cultivar of red pepper, on sympathetic nervous activity, body temperature, heart rate, and blood pressure in humans” by Hachiya S, Kawabata F, Ohnuki K, Inoue N, Yoneda H, Yazawa S, Fushiki T(38).

Sources
(a) http://www.ncbi.nlm.nih.gov/pubmed/2306288
(35) http://www.ncbi.nlm.nih.gov/pubmed/16921199
(36) http://www.ncbi.nlm.nih.gov/pubmed/12025528
(37) http://www.ncbi.nlm.nih.gov/pubmed/17202897 .
(38) http://www.ncbi.nlm.nih.gov/pubmed/17341828

Most Common Disease of elder: The Clinical trials and Studies edition of Musculo-Skeletal disorders(MSDs) - Osteoarthritis Treatment of Herbal and TCM medicine; The Herbal Formulas

Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed(1).

Types of Musculo-Skeletal disorders in elder(2)

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia

The Treatment

B. In herbal and traditional Chinese medicine perspective

B.2.2. Herbal and traditional Chinese medicine formulas
1. Phytodolor (STW 1)
Phytodolor, a fixed herbal formulation containing alcoholic extracts of aspen leaves and bark (Populus tremula), common ash bark (Fraxinus excelsior), and golden rod herb (Solidago virgaurea), has been used for treatment in painful inflammatory or degenerative rheumatic diseases(483), probably due to its antiinflammatory, antioedematous, antioxidative and analgesic properties(483).
According to the University Hospital Zurich, in the review of the data base of randomized controlled trials (RCTs), STW1 can be used as non-steroidal anti-inflammatory drugs (NSAIDs) in relieving pain in patient with musculoskeletal disorders, including osteoarthritis(484). DR. Gundermann KJ and Dr., Müller J. in the study of painful inflammatory or degenerative rheumatic diseases, said" Phytodolor (STW 1) is a reasonable alternative to NSAIDs and to cyclooxygenase(COX)-2-inhibitors such as rofecoxib"(483) and "STW 1 has a high drug safety"(483) with little side effects(486).

The formula although is found to be effective in some extension in treating pain for patient with MD, some research suggested that most popular CAM therapies for pain from arthritis-related conditions, should be gone through additional high quality research, especially for herbals and homeopathy(485).

2. Reumalex
Reumalex, is a herbal medicine formula containing 100 mg White Willow bark, 40 mg, Guaiacum Resin BHP, 35 mg Black Cohosh, 25 mg Extract of Sarsparilla and 17 mg Extract of Poplar Bark. In a 2 months without cross-over study, in 82 subjects with chronic arthritic pain, Dr. Mills SY and the research team at the University of Exeter showed that Reumalex, the herbal medicine improved the pain symptoms through its mild analgesic effect(487).

3. Gitadyl
Gitadyl is another herbal medicine formula containing 110 mg feverfew, 90 mg American aspen and 60 mg milfoil(488). According to a double-blind, randomized, cross-over study conducted by Hvidovre Hospital, in comparison of the effectiveness of herbal formula Gitadyl and conventional medicine ibuprofen(490) in patients with osteoarthritis, researchers found that Gitadyl can be used for treatment of such as reduced pain(488) and working ability(488) of patient with osteoarthritis who are prone to bleeding or who develop gastrointestinal (GI) symptoms from NSAIDs(489),

4. SKI306X

SKI306X, is a herbal formula containing Clematis mandshurica (CM), Prunella vulgaris (PV), and Trichosanthes kirilowii (TK),

According to the study by the Hanyang University Hospital for Rheumatic Diseases, SKI3006X, reduced pain and improve physical performance(498) by inhibited degradation of glycosaminoglycan (GAG) through its expression on anti inflammatory(497)(499) and analgesic(499)properties in interleukin (IL)-1β induced gene expression in human OA(497). In a a double-blind placebo controlled study of 96 patients with classical osteoarthritis of the knee, SKI 306X at 100mm demonstrated its clinical efficacy in comparison to placebo, according to the Chung-Ang University(500).

5. Duhuo Jisheng Wan (DJW)
Duhuo Jisheng Wan (DJW)or Duhuo Jisheng Tang (DJT) is a Chinese herbal formula containing over 18 individual herbs(501) has been used for treatment of knee osteoarthritis with limit scientific evidence(502), according to the Nestlé Research Center(503), but in a randomized, double-blind, double-dummy, controlled trial of a total of 200 patients suffering from OA of the knee, researcher at the Chiang Mai University, showed to improve walking pain, standing pain and stiffness, with approximately 30% of patients in both groups experienced mild adverse events(504).
The Taipei City Hospital study of Duhuo Jisheng Wan(DJW) also supported the effectiveness of the herbal formula in reduced pain, stiffness and improved physical functioning as well as other symptoms of degenerative osteoarthritis of the knee(502).

6. Huo-Luo-Xiao-Ling (HLXL) Dan
Huo-Luo-Xiao-Ling (HLXL) Dan is a Chinese herbal formula containing Ru Xiang (Boswellia carterii Birdw.), Mo Yao (Commiphora myrrha Engl.), Dang Gui (Angelica sinensis (Oliv.) Diels) and Dan Shen (Salvia miltiorrhiza Bge), used over thousands of year in Chinese history for treatment in alleviating pain caused rheumatoid arthritis (RA) and other inflammatory disorders(505)(508). On a Phase II clinical trial at Kernan Hospital of the University of Maryland School of Medicine, the herbal formula moderately inhibited hyperanalgesic (severe pain killing)(508) with no side effect in comparison to placebo(506) in patient with osteoarthritis OA. The phase II clinical trials also showed treatment of HLXL-Dan was not superior to placebo in pain relief or functional improvement in patients with knee OA if use only in 8 weeks(507).

7. Si Miao Fang
SI Miao Fang is a herbal formula comprised of Phellodendri Chines Cortex, Atractylodis rhizoma, Coicis Semen, and Achyranthis bidentatae Radix used in traditional Chinese medicine for pain relief, due to inflammation and and analgesics(509) in patient with gouty arthritis(510) and rheumatoid arthritis(511). In osteoarthritic rat model, according to the China Academy of Chinese Medical Sciences, herbal formula inhibited expression of matrix metalloproteinases (MMPs) -3 and -13 and aggrecanases (ADAMTS) -4 and -5, induced OA causes of cartilage matrix degradation, by increasing proteoglycan and collagen content(512) through its interferes with secretion of pro-inflammatory cytokines and inflammatory mediators(512).

8. Other Chinese herbal prescription for treatment of OA, according to Osteoporosis & Osteoarthritis in TCM Therapy by Chun Yi, Lu O.M.D., LAc. may also include Shu Jing Huo Xue Tang

Shu Jing Huo Xue Tang can be prescribed for treatment of patient with osteoarthritis caused by blood stagnation and blood stasis induced chronic pain syndromes, through its effect in suppressed neuropathic pain behaviors(514), including adjuvant arthritis(515). According to the article of Osteoporosis & Osteoarthritis in TCM Therapy by Chun Yi, Lu O.M.D., LAc(513), the formula can also used for treatment of OA patient due to the effects in induced blood downward movement, strengthened the movement of bone, relived pain, improved joint function and inhibited inflammation causes of swollen of the joint lining and (513).

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

References

(483) Phytodolor--effects and efficacy of a herbal medicine by Gundermann KJ1, Müller J.(PubMed)
(484) Phytodolor® in musculoskeletal disorders: re-analysis and meta-analysis by Uehleke B1, Brignoli R, Rostock M, Saller R, Melzer J.(PubMed)
(485) Selected CAM therapies for arthritis-related pain: the evidence from systematic reviews.
Soeken KL1.(PubMed)

(486) EFFECT OF A PROPRIETARY HERBAL MEDICINE ON THE RELIEF OF CHRONIC ARTHRITIC PAIN: A DOUBLE-BLIND STUDY by S. Y. MILLS, R. K. JACOBY*, M. CHACKSFIELD and M. WILLOUGHBY(Rheumatology)
(487) Effect of a proprietary herbal medicine on the relief of chronic arthritic pain: a double-blind study by Mills SY1, Jacoby RK, Chacksfield M, Willoughby M.(PubMed)
(488) [Gitadyl versus ibuprofen in patients with osteoarthrosis. The result of a double-blind, randomized cross-over study].[Article in Danish]by Ryttig K1, Schlamowitz PV, Warnøe O, Wilstrup F.(PubMed)
(489) Gitadyl versus ibuprofen in patients with osteoarthritis: a double-blind, randomized, cross-over study of clinical efficacy and effects on platelets and PMNs by Mieszczak CI1, Kharazmi A, Rein J, Winther K.(PubMed)
(490) [Gitadyl versus ibuprofen].[Article in Danish] by [No authors listed](PubMed)

(491) Danshen prevents articular cartilage degeneration via antioxidation in rabbits with osteoarthritis by Bai B1, Li Y2.(PubMed)

(492) Veterinary Herbal Medicine By Susan G. Wynn, Barbara Fougère, page 349.

(493) Dan Shen (Salvia miltiorrhiza) in Medicine: Volume 2. Pharmacology ..., Volume 2 edited by Xijun Yan
(494) [Comparative analysis on composition principles of traditional Chinese medicine prescriptions for osteoporosis and osteoarthritis].[Article in Chinese] by Zheng ZR, Tang SH.(PubMed)
(495) Complementary and Alternative Medicine Use Among Adults and Children: United States, 2007 by Patricia M. Barnes, M.A., and Barbara Bloom, M.P.A., Division of Health Interview Statistics, National Center for Health Statistics; and Richard L. Nahin, Ph.D., M.P.H., National Center for Complementary and Alternative Medicine, National Institutes of Health
(496) Chinese Herbal Bath Therapy for the Treatment of Knee Osteoarthritis: Meta-Analysis of Randomized Controlled Trials by Chen B1, Zhan H1, Chung M2, Lin X1, Zhang M1, Pang J1, Wang C3.(PubMed)

(497) Assessment of comparative pain relief and tolerability of SKI306X compared with celecoxib in patients with rheumatoid arthritis: a 6-week, multicenter, randomized, double-blind, double-dummy, phase III, noninferiority clinical trial by Song YW1, Lee EY, Koh EM, Cha HS, Yoo B, Lee CK, Baek HJ, Kim HA, Suh YI, Kang SW, Lee YJ, Jung HG.(PubMed)

(498) SKI306X inhibition of glycosaminoglycan degradation in human cartilage involves down-regulation of cytokine-induced catabolic genes by Choi CH1, Kim TH2, Sung YK2, Choi CB2, Na YI3, Yoo H4, Jun JB2.(PubMed)

(499) Effects of SKI306X on arachidonate metabolism and other inflammatory mediators by Kim JH1, Ryu KH, Jung KW, Han CK, Kwak WJ, Cho YB.(PubMed)

(500) Effect of SKI 306X, a new herbal anti-arthritic agent, in patients with osteoarthritis of the knee: a double-blind placebo controlled study by Jung YB1, Roh KJ, Jung JA, Jung K, Yoo H, Cho YB, Kwak WJ, Kim DK, Kim KH, Han CK(PubMed)

(501) Du Huo Ji Sheng Tang(American Dragon)

(502) Duhuo Jisheng Tang for treating osteoarthritis of the knee: a prospective clinical observation by Jung-Nien Lai,1 Huey-Jeng Chen,2 Chao-Chung Chen,3 Jer-Huei Lin,4 Jing-Shiang Hwang,5 and Jung-Der Wang(PMC)

(503) Osteoarthritis and nutrition. From nutraceuticals to functional foods: a systematic review of the scientific evidence by Ameye LG1, Chee WS.(PubMed)

(504) Chinese herbal recipe versus diclofenac in symptomatic treatment of osteoarthritis of the knee: a randomized controlled trial [ISRCTN70292892] by Teekachunhatean S1, Kunanusorn P, Rojanasthien N, Sananpanich K, Pojchamarnwiputh S, Lhieochaiphunt S, Pruksakorn S.(PubMed)

(505) Chinese Herbal Formula Huo-Luo-Xiao-Ling Dan Protects against Bone Damage in Adjuvant Arthritis by Modulating the Mediators of Bone Remodeling by Siddaraju M. Nanjundaiah,1 David Y.-W. Lee,2 Brian M. Berman,3 and Kamal D. Moudgil(Hindawi Publishing Corporation)

(506) Dose Escalation Study Of Chinese Herbs In Osteoarthritis Of The Knee (TCM-OAK)(Clinical trial. Gov)

(507) Huo-Luo-Xiao-Ling (HLXL)-Dan, a Traditional Chinese Medicine, for patients with osteoarthritis of the knee: a multi-site, randomized, double-blind, placebo-controlled phase II clinical trial by Lao L1, Hochberg M2, Lee DY3, Gilpin AM4, Fong HH5, Langenberg P6, Chen K7, Li EK8, Tam LS9, Berman B10.(PubMed)

(508) Anti-hyperalgesic and anti-inflammatory effects of the modified Chinese herbal formula Huo Luo Xiao Ling Dan (HLXL) in rats by Lao L1, Fan AY, Zhang RX, Zhou A, Ma ZZ, Lee DY, Ren K, Berman B.(PubMed)

(509) Experimental Study on Anti-Inflammatory Effect and Analgesic Effect of Simiao Powder by Jing Yun, Li weilin

(510) Randomized and controlled clinical study of modified prescriptions of Simiao Pill in the treatment of acute gouty arthritis by Shi XD1, Li GC, Qian ZX, Jin ZQ, Song Y.(PubMed)

(511) [Effects and mechanisms of Simiao pill on adjuvant arthritis rats model].[Article in Chinese]by Wang X1, Zhang X, Zhang L, Li Y.(PubMed)

(512) Treatment with SiMiaoFang, an anti-arthritis chinese herbal formula, inhibits cartilage matrix degradation in osteoarthritis rat model by Xu Y1, Liu Q, Liu ZL, Lim L, Chen WH, Lin N.(PubMed)

(513) Osteoporosis & Osteoarthritis in TCM Therapy by Chun Yi, Lu O.M.D., LAc.

(514) Anti-hypersensitivity effects of Shu-jing-huo-xue-tang, a Chinese herbal medicine, in CCI-neuropathic rats by Shu H1, Arita H, Hayashida M, Zhang L, An K, Huang W, Hanaoka K.(PubMed)

(515) Study of sokei-kakketu-to (shu-jing-huo-xue-tang) in adjuvant arthritis rats by Kanai S1, Taniguchi N, Higashino H.(PubMed)

Thursday, December 3, 2015

Most Common Disease of elder: The Clinical trials and Studies edition of Musculo-Skeletal disorders(MSDs) - Osteoarthritis Treatment of Herbal and TCM medicine; The Individual Herbal Medicine

B.2. Herbal and Traditional Chinese medicine
Many herbal medicine have been found effectively for reduction of symptoms and treatment for patient with osteoarthritis(430), including

B.2.1. Individual herb

1. Ginger

Ginger has been used internally and externally for over a thousand years in China to manage all types of arthritis symptoms, through its effective in compress therapy(431). According to Dr. Therkleson T., in the study of 20 adults with moderate to severe osteoarthritis(414). On a self-report arthritis Health Assessment Questionnaire, topical ginger showed to relief osteoarthritic symptoms, in both body physiological recordings and pain scale(415).

The Edith Cowan University, in the study of a self-treatment using the ginger patch for a further 24 week, showed that ginger treatment relieve symptoms, improve the overall health, and increase independence of people with chronic osteoarthritis(416).
Ginger extract, according to Frederiksberg Hospital, in adouble blind study conducted in accordance with Good Clinical Practice (European Guideline for GCP), exhibited a statistically significant effect on reducing symptoms of OA of the knee(432).

2. Willow bark

A herbal medicine used over thousands of years for treatment as an anti-inflammatory, antipyretic, and analgesic advocate in many culture(433). Its extract, according to studies may be a potential medicine for treatment of patient with painful osteoarthritis(434)(436) or used conjunction with NSAIDs and opioids(434).

In the trail of total of 78 patients (39 willow bark extract, 39 placebo),. researcher sat the Universität Tübingen showed that Willow bark extract reduces pain, stiffness and improvesphysical function
after 2 weeks of treatment for patient with OA, through its moderate analgesic effect with tolerate side effects(437).

Unfortunately, the study by the Eberhard Karls-Universität, in the 127 outpatients with hip or knee OA 2 randomized, controlled, double-blind trials with followup for 6 weeks, showed insufficient different of the herbal extract in comparison to the placebo(435).

3. Stinging nettle
Stinging nettle also known as Urtica dioica, a herbal medicine with long history for the effectiveness in treating of getting rid of water in the body and relieve pain, showed to relive pain and reduce risk of progression of the disease patients with osteoarthritis(438)(439). Application of stinging nettle daily for one week to the painful area in patient with OA, effectively relieves more pain in comparison to placebo(442)
In a randomized double-blind parallel-groups clinical trial, conduced by the University of Bordeaux, Phytalgic (fish-oil, vitamin E, Urtica dioica) improve not only the symptoms of patient with osteoarthritis. but also reduced the need for analgesics and NSAIDs(440).

Dr. Christensen R, and Dr. Bliddal H. said " Phytalgic... tested in a placebo-controlled trial for 3 months and according to the authors has a very large clinical effect, considerably larger than that of any other known product. Even experts endorsing nutraceuticals for OA symptoms.."(441).

4. Devil’s claw
Devil’s claw is also one most common used in alternative medicine for treatment of patient suffering from osteoarthritis(443), probably through anti inflammatory activity(446) in inhibition of different proinflammatory mediators(447)(448).
In the review of the data of literature on Devil's Claw and OA from 1966 to 2006, research at the University of Southampton indicated that Devil's Claw exhibits effectively the reduction of the main clinical symptom of pain in OA patient but suggestion of it safety in use is necessary(444).
Dr. Chrubasik S said that preparations of devil's claw extract, should be taken account of the presence of the quantity of harpagoside of which has proven importantly in relived painful lower back or arthrotic pain as an attractive alternative to synthetic analgesics(445).

5. Hot Chilli (Capsaicin)
Topical capsaicin is considered as alternative therapy in patient with osteoarthritis, without any severe adverse effects, according to Dr Rains C, and Bryson HM(449).

Topical Capsaicin cream used for treatment of soft tissue with a pharmaceutical name of Finalgon®(420), may be effective for treatment of osteoarthritis in dependent to its concentration.
In a randomized, single-blind, 28-day study conducted by Research Testing Laboratories, capsaicin cream (0.25%) applied twice daily, showed to relieve severity of osteoartghritic pain with side effect of burning sensation(419).

Civamide cream produced by Winston Pharmaceuticals, approved by FDA, civamide cream is a cis-isomer of capsaicin topical medication used for treatment of osteoarthritis of the knee and other neuropathic pain(417). In the study by Northwestern University Feinberg School of Medicine, in patients with OA of the knee, civamide cream 0.075% or a lower dose of civamide cream, 0.01% effectively in relieve pain and improve physical functions(418).

5. Green Tea
Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years.

In mouse model, epigallocatechin 3-gallate (EGCG), a polyphenol present in green tea, exhibited reduced OA palliative effect and progression, through less Safranin O loss and cartilage erosion(450) by attenuating the inflammation induced by calcium pyrophosphate crystals(452)(453).
Sunphenon, a green tea extract has shown to enhance bone mineralization, relieves osteoarthritis, and aids digestion, through its antioxidant effects(451).

According to the Texas Tech University Health Sciences Center, epigallocatechin gallate and green tea extract, suppressed the condition caused in part by injury, loss of cartilage structure and function, through their effects in balanced inflammatory and anti-inflammatory pathways(454), probably caused by IL-1β, a major cytokine driving the inflammatory processes(455)(456).

6. Turmeric
Turmeric, a cooking spice used in many culture in South East Asian, especially in India, also has been used as herbal medicine over thousands of year as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.(457). Curcumin (Cur) and bisdemethoxycurcumin (BDMC), extracted from Curcuma longa slow osteoarthritis progression against bone turn over through the stimulation of interleukin (IL)-1β , downregulate the expression of inflammatory markers on osteoblasts(459).
The joint study St. Louis University School of Medicine and University of Nebraska Medical Center in review of research at the laboratory, translational and clinical levels data found that most the studies and trails supports the use of curcumin for various musculoskeletal disorders, including osteoarthritis, osteoporosis,..(458). In the antioxidant perspective, curcuminoids relieve osteoarthritis symptoms. through reduction of systemic oxidative stress(460) in patients with knee osteoarthritis(460).

The Belgium study of 820 patients treated with a new Curcuma extract (Flexofytol®, 4-6 capsules per day), suggested that the extract improves patient pain, articular mobility, and quality of life. Within the first 6 weeks, more than half of participants were able to discontinue analgaesic and anti-inflammatory drugs with tolerate adverse effects(461)

7. Cat's claw
Cat's claw (Uncaria tomentosa), the very commonherbal medicine, has been used in traditional medicine over two thousand years as a tonic, contraceptive, anti-inflammatory and infectious agent, and to treat diarrhea, rheumatic disorders, acne, diabetes, cancer and diseases of the urinary tract, etc.(462). The The natural mineral supplement, sierrasil combined with a cat's claw extract, may be protential treatment to improved joint health, according to a a randomized controlled trial (466). Recently, according to the study by Case Western Reserve University, herbal and amino acid mixture containing extract of the Uncaria tomentosa, may be potentially useful as a new adjunct therapeutic/preventive agent for OA or injury recovery effectively, due to its anti inflammatory(464) and chondroprotective activities, in up-regulation of ACAN and COL2A1 expression in IL-1β-stimulated and inhibiting the activation of nuclear factor (NF)-kB in human OA chondrocytes(463) as well as reducing of pro-inflammatory mediators and effectors(464).
The Facultad de Medicina, in the comparison of the species U guianensis and U tomentosa, found that both herbal medicine are effective in treatment of Osteoarthritis, probably through its anti-inflammatory properties in inhibited TNFalpha and PGE2 production(465).

8. Bromelain
Bromelain, a group of protein digesting enzymes found in pineapples (Ananas comosus) has been used in traditional medicine as inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.(467). The herbal medicine may be used as valuable and safe alternative to NSAIDs in patients suffering acute and chronic OA pain from degenerative joint diseases due to its anti-inflammatory and analgesic effects(468).

According to the Rehabilitation Centre for Cardiovascular and Rheumatic Diseases, oral enzyme therapy (Phlogenzym-(PE)), has found effectively in treatment for patient with osteoarthritis with high levels of pain due to signs of inflammation(469). Other oral enzyme-rutosid combination (ERC) containing rutosid and the enzymes bromelain and trypsin, showed to consist the same effectiveness as NSAIDs in the treatment of painful episodes of OA of the knee(471).
Dr. Brien S and the research team in the study of the anti-inflammatory and analgesic properties in patient with osteoarthritis said that more studies and trials are necessary to trials to establish the efficacy and optimum dosage for bromelain as a safer alternative or adjunctive treatment for osteoarthritis(470).

10. Boswellia serrata
Boswellia serrata used as incense in religious and cultural ceremonies and in medicine over thousands of year may be the potential source for treatment of osteoarthritis due to its anti inflammatory(472), anti-arthritic and analgesic activity activity(473) in decreased knee pain, increased knee flexion and increased walking distance(473).
FlexiQule, the commercial Boswellia extract, improved pain, stiffness, physical, social/emotional functions and walking distance at 4 weeks of treatment with patient of symptomatic knee osteoarthritis (OA)(474), the Circulation Sciences and the International Irvine Network suggested.

DR. Kizhakkedath said that formula containing Curcuma longa and Boswellia serrata extracts (CB formulation) at 500 mg administered twice a day in a directly compared with the selective COX-2 inhibitor, celecoxib at 100 mg twice a day, induced more successful symptom scoring and clinical examination(475).

The study of Indira Gandhi Medical College also supported of Boswellia extract effectiveness by decreasing in knee pain, increasing knee flexion and walking distance of in the study of 30 patient with osteoarthritis of knee(476).

11. Gingko
Gingko is also known as Ginkgo biloba, one of the oldest herbal medicine in human medical history, used in traditional herbal medicine in treating impotence, memory loss,respiratory diseases, circulatory disorders,,...(477).

Gingko extract, with anti inflammatory(478) and immune modulatory(479) activities may be a potential herbal medicine for treatment of osteoarthritis by inhibiting the interleukin-1 (IL-1)-stimulated human chondrocytes degeneration and MMP(matrix metalloproteinases)-1, MMP-3, and 13.causes of cartilage degradation(481)(482) found in patient of osteoarthritis(480) of which make the extract the candidate as a potential therapeutic agent, according to the Postgraduate Institute of Medical Education and Research(480).

In Osteoarthritis (OA) rat model, the extract EGb761, a standardized extract of Ginkgo biloba leaves also expressed its anti inflammatory effect on human articular chondrocytes of which inhibited cartilage degradation(482).

12. Dan Shen
Dan Shen with the pharmaceutical name of Radix Salvia miltiorrhizae, is a bitter and slightly cold herb, used mainly in traditional Chinese medicine for tonifying blood(494), such as getting rid of clot blood, invigorate blood, breakup blood stasis,... through its effects on liver and heart meridians.
In the animal model study of rabbits, with severe articular cartilage degeneration and lower proteoglycan (PG), the herbal medicine Dan Shen showed effectively in against oxidative stress causes ofarticular cartilage degeneration in patient with Osteoarthritis OA(491).
According to Veterinary Herbal Medicine By Susan G. Wynn, Barbara Fougère, page 349. Dan Shen induced formation of dense callus and increased activity of osteoblasts of which enhanced the improvement of bone heeling(492). Certain studies found in Dan Shen (Salvia miltiorrhiza) in Medicine: Volume 2. Pharmacology ..., Volume 2 edited by Xijun Yan also supported the use of Dan Shen injection for treatment of osteoarthritis because of its anti inflammatory effect(493).

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca p/general-health.html

(430) Herbal medicines for the treatment of osteoarthritis: a systematic review by L. Long, K. Soeken 1 and E. Ernst(Rheumatology)

(431) Ginger compress therapy for adults with osteoarthritis by Therkleson T1.(PubMed)

(432) Effects of a ginger extract on knee pain in patients with osteoarthritis by Altman RD1, Marcussen KC.(PubMed)

(433) Efficacy and Safety of White Willow Bark (Salix alba) Extracts by Shara M1, Stohs SJ2.(PubMed)

(434) Willow bark extract STW 33-I in the long-term treatment of outpatients with rheumatic pain mainly osteoarthritisor back pain by Uehleke B1, Müller J, Stange R, Kelber O, Melzer J.(PubMed)

(435) Efficacy and safety of willow bark extract in the treatment of osteoarthritis and rheumatoid arthritis: results of 2 randomized double-blind controlled trials by Biegert C1, Wagner I, Lüdtke R, Kötter I, Lohmüller C, Günaydin I, Taxis K, Heide L.(PubMed)

(436) Willow bark extract, a useful alternative for the treatment of osteoarthritis: comment on the editorial by Marcus and Suarez-Almazor by Chrubasik S, Pollak S, Black A.(PubMed)

(437) Efficacy and tolerability of a standardized willow bark extract in patients with osteoarthritis: randomized placebo-controlled, double blind clinical trial by Schmid B1, Lüdtke R, Selbmann HK, Kötter I, Tschirdewahn B, Schaffner W, Heide L.(PubMed)

(438) STINGING NETTLE CREAM FOR OSTFOARTHRITIS by Keith Rayburn, MD; Eric Fleischbein, PharmD; Jessica Song, PharmD; Blaine Allen, RN; Mary Kundert, PharmD; Charles Leiter, PharmD; Thomas Bush, MD(Research letter)

(439) Stinging nettle cream for osteoarthritis by Rayburn K1, Fleischbein E, Song J, Allen B, Kundert M, Leiter C, Bush T.(PubMed)

(440) Phytalgic, a food supplement, vs placebo in patients with osteoarthritis of the knee or hip: a randomised double-blind placebo-controlled clinical trial by Jacquet A1, Girodet PO, Pariente A, Forest K, Mallet L, Moore N.(PubMed)

(441) Is Phytalgic(R) a goldmine for osteoarthritis patients or is there something fishy about this nutraceutical? A summary of findings and risk-of-bias assessment by Christensen R, Bliddal H.(PubMed)

(442) Randomized controlled trial of nettle sting for treatment of base-of-thumb pain by Randall C1, Randall H, Dobbs F, Hutton C, Sanders H.(PubMed)

(443) The use of glucosamine, devil's claw (Harpagophytum procumbens), and acupuncture as complementary and alternative treatments for osteoarthritis by Sanders M1, Grundmann O.(PubMed)

(444) Devil's Claw (Harpagophytum procumbens) as a treatment for osteoarthritis: a review of efficacy and safety by Brien S1, Lewith GT, McGregor G.(PubMed)

(445) [Devil's claw extract as an example of the effectiveness of herbal analgesics].[Article in German] by Chrubasik S1.(PubMed)

(446) A complex of three natural anti-inflammatory agents provides relief of osteoarthritis pain by Conrozier T, Mathieu P, Bonjean M, Marc JF, Renevier JL, Balblanc JC.(PubMed)

(447) Alteration of anti-inflammatory activity of Harpagophytum procumbens (devil's claw) extract after external metabolic activation with S9 mix by Hostanska K1, Melzer J, Rostock M, Suter A, Saller R.(PubMed)

(448) A review of the efficacy and safety of devil's claw for pain associated with degenerative musculoskeletal diseases, rheumatoid, and osteoarthritis by Denner SS1.(PubMed)

(449) Topical capsaicin. A review of its pharmacological properties and therapeutic potential in post-herpetic neuralgia, diabetic neuropathy and osteoarthritis by Rains C1, Bryson HM.(PubMed)

(450) Green tea polyphenol treatment is chondroprotective, anti-inflammatory and palliative in a mouse post-traumaticosteoarthritis model by Leong DJ, Choudhury M, Hanstein R, Hirsh DM, Kim SJ, Majeska RJ, Schaffler MB, Hardin JA, Spray DC, Goldring MB, Cobelli NJ, Sun HB.(PubMed)

(451) Antioxidant and pro-apoptotic effects of marine-derived, multi-mineral aquamin supplemented with a pine bark extract, Enzogenol, and a green tea extract, Sunphenon. by O'Callaghan YC1, Drummond E, O'Gorman DM, O'Brien NM.(PubMed)

(452) Epigallocatechin-3-gallate reduces inflammation induced by calcium pyrophosphate crystals in vitro by Oliviero F1, Sfriso P, Scanu A, Fiocco U, Spinella P, Punzi L.(PubMed)

(453) Epigallocatechin-3-gallate selectively inhibits interleukin-1beta-induced activation of mitogen activated protein kinase subgroup c-Jun N-terminal kinase in human osteoarthritis chondrocytes. by Singh R1, Ahmed S, Malemud CJ, Goldberg VM, Haqqi TM.(PubMed)

(454) Dietary polyphenols and mechanisms of osteoarthritis by Shen CL1, Smith BJ, Lo DF, Chyu MC, Dunn DM, Chen CH, Kwun IS.(PubMed)

(455) Green tea: a new option for the prevention or control of osteoarthritis by Katiyar SK, Raman C.(PubMed)

(456) Epigallocatechin-3-gallate selectively inhibits interleukin-1beta-induced activation of mitogen activated protein kinase subgroup c-Jun N-terminal kinase in human osteoarthritis chondrocytes by Singh R1, Ahmed S, Malemud CJ, Goldberg VM, Haqqi TM.(PubMed)

(457) Popular #Herbs - Turmeric (Curcuma longa) by Kyle J. Norton
(458) Role of Curcumin in Common Musculoskeletal Disorders: a Review of Current Laboratory, Translational, and Clinical Data by Peddada KV1, Peddada KV2, Shukla SK3, Mishra A3, Verma V4.(PubMed)
(459) Evaluation of the protective effects of curcuminoid (curcumin and bisdemethoxycurcumin)-loaded liposomes against bone turnover in a cell-based model of osteoarthritis by Yeh CC1, Su YH2, Lin YJ2, Chen PJ2, Shi CS3, Chen CN2, Chang HI2.(PubMed)
(460) Mitigation of Systemic Oxidative Stress by Curcuminoids in Osteoarthritis: Results of a Randomized Controlled Trial by Panahi Y1, Alishiri GH, Parvin S, Sahebkar A.(PubMed)
(461) A new curcuma extract (flexofytol®) in osteoarthritis: results from a belgian real-life experience by Appelboom T1, Maes N2, Albert A3.(PubMed)
(462) Cat's claw (Uncaria tomentosa) by Kyle J. Norton
(463) Effect of a Herbal-Leucine mix on the IL-1β-induced cartilage degradation and inflammatory gene expression in human chondrocytes by Akhtar N1, Miller MJ, Haqqi TM.(PubMed)
(464) Cat's claw: an Amazonian vine decreases inflammation in osteoarthritis by Hardin SR1.(PubMed)
(465) Efficacy and safety of freeze-dried cat's claw in osteoarthritis of the knee: mechanisms of action of the species Uncaria guianensis by Piscoya J1, Rodriguez Z, Bustamante SA, Okuhama NN, Miller MJ, Sandoval M.(PubMed)
(466) Early relief of osteoarthritis symptoms with a natural mineral supplement and a herbomineral combination: a randomized controlled trial [ISRCTN38432711] by Miller MJ1, Mehta K, Kunte S, Raut V, Gala J, Dhumale R, Shukla A, Tupalli H, Parikh H, Bobrowski P, Chaudhary J.(PubMed)

(467) Popular #Herbs - Bromelain by Kyle J. Norton

(468) A complex of three natural anti-inflammatory agents provides relief of osteoarthritis pain by Conrozier T, Mathieu P, Bonjean M, Marc JF, Renevier JL, Balblanc JC.(PubMed)

(469) Efficacy and tolerance of an oral enzyme combination in painful osteoarthritis of the hip. A double-blind, randomised study comparing oral enzymes with non-steroidal anti-inflammatory drugs by Klein G1, Kullich W, Schnitker J, Schwann H.(PubMed)

(470) Bromelain as a Treatment for Osteoarthritis: a Review of Clinical Studies by Brien S, Lewith G, Walker A, Hicks SM, Middleton D.(PubMed)

(471) Oral enzyme combination versus diclofenac in the treatment of osteoarthritis of the knee--a double-blind prospective randomized study by Akhtar NM1, Naseer R, Farooqi AZ, Aziz W, Nazir M.(PubMed)
(472) Boswellia Serrata, A Potential Antiinflammatory Agent: An Overview by M. Z. Siddiqui(PMC)
(473) Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee--a randomized double blind placebo controlled trial by Kimmatkar N1, Thawani V, Hingorani L, Khiyani R.(PubMed)
(474) FlexiQule (Boswellia extract) in the supplementary management of osteoarthritis: a supplement registry by Belcaro G1, Dugall M, Luzzi R, Ledda A, Pellegrini L, Cesarone MR, Hosoi M, Errichi M, Francis S, Cornelli U.(PubMed)
(475) Clinical evaluation of a formulation containing Curcuma longa and Boswellia serrata extracts in the management of knee osteoarthritis by Kizhakkedath R1.(PubMed)
(476) Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee--a randomized double blind placebo controlled trial by Kimmatkar N1, Thawani V, Hingorani L, Khiyani R.(PubMed)
(477) Popular Herbs - Ginkgo biloba by Kyle J. Norton
(478) Ginkgo biloba extract EGb 761 has anti-inflammatory properties and ameliorates colitis in mice by driving effector T cell apoptosis by Venkata S. Kotakadi,† Yu Jin,† Anne B. Hofseth, Lei Ying, Xiangli Cui, Suresh Volate, Alexander Chumanevich, Patricia A. Wood,1 Robert L. Price,2 Anna McNeal,2 Udai P. Singh,2 Narendra P. Singh,2 Mitzi Nagarkatti,2 Prakash S. Nagarkatti,2 Lydia E. Matesic,3 Karine Auclair,4 Michael J. Wargovich,5 and Lorne J. Hofseth(PMC)
(479) Effectiveness of oral Ginkgo biloba in treating limited, slowly spreading vitiligo by Parsad D1, Pandhi R, Juneja A.(PubMed)
(480) Ginkgo biloba extract individually inhibits JNK activation and induces c-Jun degradation in human chondrocytes: potential therapeutics for osteoarthritis by Ho LJ1, Hung LF2, Liu FC3, Hou TY3, Lin LC4, Huang CY2, Lai JH5.(PubMed)
(481) Inhibitory effects of EGb761 on the expression of matrix metalloproteinases (MMPs) and cartilage matrix destruction by Wang X1, Zhao X, Tang S.(PubMed)
(482) EGb761 inhibits inflammatory responses in human chondrocytes and shows chondroprotection in osteoarthritic rat knee by Chen YJ1, Tsai KS, Chiu CY, Yang TH, Lin TH, Fu WM, Chen CF, Yang RS, Liu SH.(PubMed)