The Smoothie of Green Tea and Grape for treatment of Alzheimer's disease

Kyle J. Norton(Scholar)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for people with  Alzheimer's disease and high risk of the disease

Yield: 2 serving (about 8 ounce each)
1 1/2 cups grapes of any kind with seeds
1 cup green tea drink 1 cup green tea drink (Make from 4 grams(2 tea bags) of green tea, a slice of ginger and a cup of hot water lipped for 5 minutes, and set aside for cooling to room temperature)


1. Place the grapes, green tea, in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately

The findings of a natural ingredient for treatment and delay the progression of  Alzheimer's disease from scientific communities have not been abating. Many ingredients showed extremely prominent in animal studies do not produce the same effects in human trials. 

Alzheimer's disease is a severe aging chronic neurodegenerative disorder of the brain, causing problems of memory, thinking and behavior severe enough to affect language communication, lifelong hobbies and social life. 

Alzheimer's gets worse over time, and it is fatal.

Certain phytochemicals such as Ginkgo biloba flavonoids, soybean isoflavones, theanine have exhibited neuroprotective effect against AD through inhibition on Abeta-induced neurotoxicity in cell culture and AD transgenic animal models, according to Dr. Zhao Y and Dr. Zhao B at the Harbin Institute of Technology at Weihai(2).

Recent study suggested,  green tea catechins and grape skin and seed resveratrol have shown to prevent the early onset of the diseases through their anti-amyloidogenic, anti-oxidative, and anti-inflammatory properties(1) as well as exhibiting phototropic gene protective effect against the promotion of Alzheimer's disease(6)

Resveratrol (3,4',5-trihydroxystilbene) a polyphenolic compound, a naturally occurring phytochemical effectively promotes the non-amyloidogenic cleavage of the amyloid precursor protein, enhances clearance of amyloid beta-peptides, and reduces neuronal damage through its neuroprotective benefits in animal models of AD(3).

Amyloid beta (Aβ or Abeta), the peptides of 36–43 amino acids involved the the production and deposition of the amyloid-beta peptide (Abeta). Its aggregation has been strongly associated with the neurodegenerative pathology and a promotion of harmful event rated to Alzheimer's disease (AD)(5).

The Litwin-Zucker Research Center for the Study of Alzheimer's Disease and Memory Disorders, study found that people who are wine drinkers are associated with a lower incidence of Alzheimer's disease, through effects of intracellular degradation of Abeta via a mechanism that involves the proteasome in degrade unneeded or damaged proteins(4). Other researchers suggested the lower risk of red wine may be attributed to the effects of resveratrol and intracellular free-radical scavenger glutathione involved cell viability and an anti-oxidative action(7).

Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. The drink has showed to reduced risk neurodegenerative disorder, through its anti-oxidant phenolic compounds(9)

Dr. Bastianetto S and the research team at the McGill University said," the neuroprotective abilities of ... resveratrol, and (+)-catechin result from their antioxidant properties rather than their purported inhibitory effects on intracellular enzymes"(8).

Through its anti the antioxidant, anti-inflammatory, anti-amyloidogenic, neuroprotective, and cognitive action in reduced deposition of amyloid plaques and neurofibrillary tangles, as well as microglial and astroglial activation, green tea may be one of the potential therapeutic compounds used in delay the onset of AD or slow down its progression(10).

Similar to resveratrol (-)-epigallocatechin gallate (EGCG), a green tea polyphenol reduced Aβ aggregation, inhibits  toxic oligomers, Dr. Wobst HJ and the research team lead byMax Delbrück Center for Molecular Medicine said(11).

The finding of the effectiveness of Green Tea and Grape and theirs phytochemicals may serve as  cornerstones of pharmaceutical target for further studies as well as a potential medication for treatment of Alzheimer's disease.

People who are at high risk of Alzheimer's disease such as genetic mutation genes such as amyloid precursor protein (APP),.....should drink at least one cup daily and people with Alzheimer's disease should drink the juices as much as they can depending to digestive toleration.

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

References

(1) Naturally occurring phytochemicals for the prevention of Alzheimer's disease by Kim J1, Lee HJ, Lee KW.(PubMed)

(2) Natural antioxidants in prevention and management of Alzheimer's disease by Zhao Y1, Zhao B.(PubMed)

(3) Resveratrol, a neuroprotective supplement for Alzheimer's disease by Li F1, Gong Q, Dong H, Shi J.(PubMed)

(4) Resveratrol promotes clearance of Alzheimer's disease amyloid-beta peptides by Marambaud P1, Zhao H, Davies P.(PubMed)

(5) Resveratrol inhibits beta-amyloid oligomeric cytotoxicity but does not prevent oligomer formation by Feng Y1, Wang XP, Yang SG, Wang YJ, Zhang X, Du XT, Sun XX, Zhao M, Huang L, Liu RT.(PubMed)

(6) Pleiotropic Protective Effects of Phytochemicals in Alzheimer's Disease by Sergio Davinelli, 1 Nadia Sapere, 1 Davide Zella, 2 Renata Bracale, 1 Mariano Intrieri, 1 and Giovanni Scapagnini 1(PMC)

(7) Red wine ingredient resveratrol protects from beta-amyloid neurotoxicity by Savaskan E1, Olivieri G, Meier F, Seifritz E, Wirz-Justice A, Müller-Spahn F.(PubMed)

(8) Neuroprotective abilities of resveratrol and other red wine constituents against nitric oxide-related toxicity in cultured hippocampal neurons by Bastianetto S1, Zheng WH, Quirion R.(PubMed)

(9) Comparative Histological Study on the Therapeutic Effect of Green Tea and Stem Cells in Alzheimer's DiseaseComplicating Experimentally Induced Diabetes by Bassiony HS1, Zickri MB1, Metwally HG2, Elsherif HA1, Alghandour SM1, Sakr W3.(PubMed)

(10)Natural compounds and plant extracts as therapeutics against chronic inflammation in Alzheimer's disease--a translational perspective.

Apetz N, Munch G, Govindaraghavan S, Gyengesi E1.(PubMed)

(11)The green tea polyphenol (-)-epigallocatechin gallate prevents the aggregation of tau protein into toxic oligomers at substoichiometric ratios.
Wobst HJ1, Sharma A2, Diamond MI2, Wanker EE3, Bieschke J4(PubMed)

Most Common Diseases of Ages of 50 Plus - Musculoskeletal disorders (MSDs): Cervical Stenosis (with Myleopathy) -The Complications

Kyle J. Norton(Scholar)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) is medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed(1).


                    Cervical Stenosis


Cervical Stenosis is defined as a degeneration of the structures of the spine as a result of aging causes of a slowly progressive condition of the cervical spinal cord. Spinal stenosis cause pressure on the spinal cord, which may lead to the symptoms of myelopathy. Cervical spinal stenosis with myelopathy is a common disease in elderly patients of male gender(2).

The Complications
1. Numbness and paresis
There was a report of a patient with X-rays of cervical spine showed fusion at two levels: C2 and C3 vertebrae, and C4 and C5 vertebrae and had a similar cervical spinal cord injury about 15 years ago, when he developed transient numbness and paresis of the lower limbs following a fall(5).

2. Incontinence
In the study of 214 patients undergoing surgery for degenerative spinal disease at our department between January 1 and December 31, 2008, researchers at the Neurochirurgické oddelenie JLF UK a MFN, Martin showed that Degenerative spinal disease can result in acute or chronic urinary incontinence. Factors associated with its development include gender, BMI, radicular weakness and the type of degenerative disease. Surgical treatment improved or eliminated the symptoms of urinary incontinence in more than half of the patients affected(6).

3. Paralysis
Cervical stenosis can cause increased risk of paralysis, depending on where the spinal cord and nerve roots are damaged by Cervical Stenosis.

4. Chronic pelvic pain and infertility
Cervical stenosis condition often recurs despite intervention. women who encounter ecurrent stenosis are at risk of developing severe complications such as chronic pelvic pain and infertility(7).

6. Etc.

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

References

(1) http://www.ncbi.nlm.nih.gov/pubmed/7864688
(2) http://www.ncbi.nlm.nih.gov/pubmed/22426774
(5) http://www.ncbi.nlm.nih.gov/pubmed/11985781
(6) http://www.ncbi.nlm.nih.gov/pubmed/21375969
(7) http://www.ncbi.nlm.nih.gov/pubmed/22711046

The Blueberry Smoothie for treatment of Breast Cancer

Kyle J. Norton(Scholar). All right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for people with breast cancer and high risk of the disease

Yield: 2 serving (about 8 ounce each)
1 1/2 cups Blueberries
1 cup rice milk

4-6 ice cubes

1. Place all the ingredients in a blender.
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately.

The dream of finding of a natural ingredient for replacement of serious side effects of chemotherapy for treatment of breast caner has been extremely difficult, probably due to physical differences in testing subjects.

Breast cancer (malignant breast neoplasm) is a cancer originated in the tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma).

In 2010, over 250,000 new cases of breast cancer were diagnosed in women in the U.S. alone and the risk of getting invasive breast cancer during life time of a women is 1/8.

Blueberry, a flower plant, belong to the family Eriaceae and native to Northern America contains several essential phytochemicals and nutrients, including, lutein and zeaxanthin, zinc, potassium, phosphorus, iron, calcium and vitamins.

Blueberry or whole blueberry powder may hold a key for reduced risk breast cancer and for treatment of the diseases. Recent studies insisted that intake of the fruits and the fruit products showed to the improve the survival rate of women with breast cancer.

In estrogen-mediated breast cancer, blueberry-supplemented diet protect women against breast cancer induced by 17β-estradiol (E2)-mediated mammary tumorigenesis(breast cancer)(1) in animals received 5% blueberry diet, either 2 weeks prior to or 12 weeks study.

Dr. Ravoori S and the research team at the University of Louisville suggested, the effectiveness of blue berry for treatment of breast cancer may be a result of the exhibition of its phytochemicals reducing mammary tissue proliferation and tumor burden, tumor latency(2).

In fact the intake of berries reduced significantly mammary tumor incidence (10-30%) by suppressing the levels of E(2) to prevent the early onset of E(2) breast cancer(3).

Dr. Aiyer HS and Gupta RC. said, blueberries and other berries promote anti proliferation and apoptosis of breast cancer cell is due its effects in modulating enzymes of estrogen metabolism.

In breast cancer cell lines MCF7 and MDA-MB-231, pterostilbene, a phytochemical found in blueberries, effectively suppressed tumorigenesis and metastasis of cancer stem cells (CSCs) through reduced expressions in promoted(4) and increased tumor cell proliferation of breast cancer(5).

Addition to that, the joint study lead by the Indian Institute of Technology Roorkee showed that pterostilbene not only expressed itself as a effective inducer of apoptosis in human breast in affecting various cellular targets, it also may be a chemopreventive potential based on its stronger anti-proinflammatory cytokines and anti-inflammatory activities against many forms of diseases(6).

In the study of  MCF7, Hs578t and MDA-MB-231 breast cancercell lines, pterostilbene suppressed tumor growth and metastasis in MDA-MB-231, the triple-negative breast cancer  and Hs578t cells through inhibition of the migratory and invasive potential by blocking the initiate the metastatic process(7).

Further more, the phytochemical also found to inhibit breast cancer regardless of estrogen receptor (ER-α36 positive or negative breast cancer)status by inducing apoptosis(8) and anti-proliferation(9), with or without the execution of cell death in apoptotic cells(8).

The finding of the effectiveness of blueberry and its phytochemical pterostilbene may serve as a cornerstone of pharmaceutical target for further studies as well as a protential medication for treatment of breast disease.

Women who are at high risk of breast cancer such as genetic mutation genes BRCA1 and BRCA2 should drink at least one cup daily and women with breast cancer should drink the juices as much as they can depending to digestive toleration.

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

References

(1) Chemopreventive and therapeutic activity of dietary blueberry against estrogen-mediated breast cancer by Jeyabalan J1, Aqil F, Munagala R, Annamalai L, Vadhanam MV, Gupta RC.(PubMed)

(2) Inhibition of estrogen-mediated mammary tumorigenesis by blueberry and black raspberry by Ravoori S1, Vadhanam MV, Aqil F, Gupta RC.(PubMed)

(3) Berries and ellagic acid prevent estrogen-induced mammary tumorigenesis by modulating enzymes of estrogen metabolism by Aiyer HS1, Gupta RC.(PubMed)

(4) Pterostilbene, a bioactive component of blueberries, suppresses the generation of breast cancer stem cells within tumor microenvironment and metastasis via modulating NF-κB/microRNA 448 circuit by Mak KK1, Wu AT, Lee WH, Chang TC, Chiou JF, Wang LS, Wu CH, Huang CY, Shieh YS, Chao TY, Ho CT, Yen GC, Yeh CT.(PubMed)

(5) Twist modulates breast cancer stem cells by transcriptional regulation of CD24 expression by Vesuna F1, Lisok A, Kimble B, Raman V.(PubMed)

(6) Understanding the mode of action of a pterostilbene derivative as anti-inflammatory agent by Nikhil K1, Sharan S1, Palla SR2, Sondhi SM2, Peddinti RK2, Roy P3.(PubMed)

(7) Pterostilbene inhibits triple-negative breast cancer metastasis via inducing microRNA-205 expression and negatively modulates epithelial-to-mesenchymal transition by Su CM1, Lee WH2, Wu AT3, Lin YK4, Wang LS5, Wu CH6, Yeh CT7.(PubMed)

(8) Estrogen receptor-α36 is involved in pterostilbene-induced apoptosis and anti-proliferation in in vitro and in vivobreast cancer by Pan C1, Hu Y2, Li J3, Wang Z4, Huang J5, Zhang S1, Ding L5.(PubMed)

(9) Estrogen receptor-α36 is involved in pterostilbene-induced apoptosis and anti-proliferation in in vitro and in vivobreast cancer by Pan C1, Hu Y2, Li J3, Wang Z4, Huang J5, Zhang S1, Ding L5.(PubMed)

Most Common Diseases of Ages of 50 Plus - Musculoskeletal disorders (MSDs): Cervical Stenosis (with Myleopathy) -The Symptoms, Causes and Risk Factors

Kyle J. Norton(Scholar)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) is medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed(1).

                           Cervical Stenosis

 Cervical Stenosis is defined as a degeneration of the structures of the spine as a result of aging causes of a slowly progressive condition of the cervical spinal cord. Spinal stenosis cause pressure on the spinal cord, which may lead to the symptoms of myelopathy. Cervical spinal stenosis with myelopathy is a common disease in elderly patients of male gender(2).

A. SymptomsSymptoms are as of result of neurologic disease which can lead to progressive disability and eventual paralysis if without appropriate treatment, depending to the expression of the exact distribution of the myelopathy in the spinal cord. Most elders with Cervical Stenosis are experience painless symptoms, others may be experience one of more symptom, depending to the location of the compression and dysfunction of spinal cord.
1. Increased knee and ankle reflex may be a first sign of the disease
2. Tightness of gait and numbness of the legs, depending to the expression of the exact distribution of the myelopathy in the spinal cord of the individual patient, such as weakness, difficulty walking, frequent falls, etc.
3. Pins-and-needles (paraesthesia) sensation in the whole body.
4. Muscle weakness or paralysis
5. Deterioration in fine motor skills (such as handwriting or buttoning a shirt)
6. Intermittent shooting pains into the arms and legs (like an electrical shock), especially when bending their head forward (known as Lermitte’s phenomenon)
7. Arm and neck pain as a result of the myelopathy constitute a combination of cord failure at the affected level and of compression and irritation of the cervical nerve roots which leave the neck at this site, such as weakness, stiffness or clumsiness in the hands,
8. Loss of appreciation of temperature, pain and joint sense and often with impairment of bladder and bowel control, as a result of the transverse lesion of the spinal cord effecting modalities of cord transmission with spasticity of gait and increased tendon reflexes, in the later state of (3).
9. Etc.

B. Causes of risk factors
B.1. Causes
Cervical Stenosis with Myleopathy may be result of degenerative changes within the spine or bone spurs of that can lead to the size of the spinal canal becoming smaller and bone spurs begin to press on the spinal cord or the nerve roots due to related to age, genetics, and wear and tear of daily living. Tumor located between the spinal cord and vertebrae can cause Cervical Stenosis with Myleopathy
B.2. Risk factors
1. Aging and gender
If you are male and over 50 years of age, you are at higher risk to develop Cervical Stenosis with Myleopathy.
2. Genetics
Congenital narrowing of the cervical spinal canal may result in cord compression without a history of injury and occasionally without evidence of significant bony degenerative changes(4).
3. Wear and tear of daily living
Tear and wear, injure can cause scar tissues and weaken the function of disc in absorbing shock, causing pressure on the spinal cord.
4. Injure
Injure to the spine can cause scar tissues which can weaken the spinal tissues, such as thickened ligaments.
5. Etc.

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
References
(1) http://www.ncbi.nlm.nih.gov/pubmed/7864688
(2) http://www.ncbi.nlm.nih.gov/pubmed/22426774
(3)http://www.saspine.org/conditions/cervical_spinal_stenosis_myelopathy.htm
(4) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC492191/

The Smoothie Recipe of Tangerine peels and Grapes For Lung Cancer

Kyle J. Norton(Scholar)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for people with lung cancer and high risk of the disease

Yield: 2 serving (about 8 ounce each)
1 1/2 cups grapes of any kind with seeds

1 medium tangerine peels
1 cup rice milk


1. Place the grapes, tangerine peels, rice milk, in a blender and puree about 1 minute 

2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately

Recent studies suggested that tangerine peels and grape skin and seeds may have a potential effect on treatment of patient with lung cancer.

Lung cancer is defined as a condition of the abnormal growth of the cells in the lung's tissue. Most common form of primary lung cancers are derived from epithelial cells. In Us, Lung cancer is the leading cause of cancer deaths, causing 158,683 people deaths, including 88,329 men and 70,354 women, according to 2007 statistic.

Tangerine, one of the winter fruits found on Chinese New year represent prosperity and good fortune, now has been cultivated all over the world in suitable climate for commercial and health benefits. The peel of the fruit also has been recorded in Chinese herbal medicine over thousand of years for treatment of respiratory diseases, including cough, asthma,.........

Epidemiological study suggested that Tangeretin has long been found to consist the ability in inhibition of apoptosis of human gastric cancer AGS cells through extrinsic and intrinsic signaling pathways (such as P53 antigen and caspase activation).

Tangeretin, a major phytochemicals in tangerine peels, in vitro and in vivo exhibited anti lung cancer effects through induced CL1-5 cell apoptosis and autophagy and inhibited NSCLC cell proliferation, and induce G(2)/M phase arrest and via the mitochondrial apoptotic pathway and autophagy(1)

"By interference of the cancer cell division and destruction of the function of new cell formation in mitochondrial apoptotic pathway involved the The Bcl-2 family of proteins" Kyle J. Norton said " The finding of tangeretin may provide us a natural sources for treatment of lung with little or no adverse effect".

In support of the finding, Dr. Charoensinphon N and the research team at the University of Massachusetts suggested, in comparison of the effects of Tangeretin (TAN) and 5-demethyltangeretin (5DT) on three human nonsmall cell lung cancer (NSCLC) cells, 5DT inhibited NSCLC cell growth by inducing G2/M cell cycle arrest and apoptosismuch stronger than the phytochemical TAN(2).

Other study also insisted that the effectiveness of the phytochemicals for treatment of  lung cancer in tangerine peel may be associated to the suppression of inflammation and cell proliferation in the Nuclear factor-κB (NF-κB) family and certain signaling proteins(5).

Grape skin and seeds contains many concentrations, including vitamin E, flavonoids, linoleic acid,oligomeric proanthocyanidins(OPCs), etc..The herb has been used in traditional medicine as antioxidant, anti-inflammatory agents.

Resveratrol, an phytochemical found abundantly in grape seed and skin is a class of Stilbenoids. Epidemiologically, the antioxidant has found effectively for treatment many types of cancer(6) including prostate cancer(7).

Dr. Zhu Y and the research team at the Genomic Medicine Institute, Cleveland Clinic indicated the effects of resveratrol for treatment of non-small cell lung cancer (NSCLC) patients with activating EGFR mutations, probably through induction of cell apoptosis, autophagy, cell cycle arrest and senescence accompanied by increased expression of anti inflammation and proliferation pathways(8).

Analogue of resveratrol, (Z)3,4,5,4'-trans-tetramethoxystilbene (TMS), also inhibited gefitinb-resistant non-small cell lung cancer through inducing apoptosis and autophagy via mediation of calcium signaling pathway(9). 

Other studies in support of the above include the joint study lead by the Northeast Ohio Medical University, Rootstown,showed that resveratrol inhibits lung cancer cells, through activation of GADD45α in induction of cancer cell suicide(10). Dr. Sancho M and Dr. Mach N said," The wine polyphenols plays a significant role as antioxidant and prooxidant in cancer, although more extensive studies are required to determine the clinical significance in humans"(11).

" The combination of tangerine and grape smoothie may hold a key to reduce risk for people who are at higher risk of lung cancer as well as for treatment of patient who have already developed the disease" Mr. Kyle J. Norton said, " people with lung cancer in any stage should drink as much as they can depending to the digestive toleration"

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

References

(1) Tangeretin Derivative, 5-Acetyloxy-6,7,8,4'-tetramethoxyflavone Induces G2/M arrest, Apoptosis and Autophagy in Human Non-Small Cell Lung Cancer Cells In vitro and In vivo(PubMed)

Li YR1, Li S2, Ho CT3, Chang YH1, Tan KT1,4, Chung TW5, Wang BY6, Chen YK7, Lin CC1.

(2) 5-demethyltangeretin inhibits human nonsmall cell lung cancer cell growth by inducing G2/M cell cycle arrest and apoptosis by  Charoensinphon N1, Qiu P, Dong P, Zheng J, Ngauv P, Cao Y, Li S, Ho CT, Xiao H.(PubMed)

(3) Tangeretin, a citrus polymethoxyflavonoid, induces apoptosis of human gastric cancer AGS cells through extrinsic and intrinsic signaling pathways by Dong Y1, Cao A2, Shi J3, Yin P2, Wang L2, Ji G4, Xie J4, Wu D2.(PubMed)

(4) Tangeretin enhances radiosensitivity and inhibits the radiation-induced epithelial-mesenchymal transition of gastric cancer cells by Zhang X1, Zheng L1, Sun Y1, Wang T2, Wang B3(PubMed)

(5) Tangeretin suppresses IL-1beta-induced cyclooxygenase (COX)-2 expression through inhibition of p38 MAPK, JNK, and AKT activation in human lung carcinoma cells by Chen KH1, Weng MS, Lin JK.(PubMed)

(6) Fighting cancer with red wine? Molecular mechanisms of resveratrol by Kraft TE1, Parisotto D, Schempp C, Efferth T.(PubMed)

(7) Resveratrol regulates the PTEN/AKT pathway through androgen receptor-dependent and -independent mechanisms in prostate cancer cell lines by Wang Y1, Romigh T, He X, Orloff MS, Silverman RH, Heston WD, Eng C.(PubMed)

(8) Resveratrol overcomes gefitinib resistance by increasing the intracellular gefitinib concentration and triggering apoptosis, autophagy and senescence in PC9/G NSCLC cells by Zhu Y1, He W1, Gao X1, Li B1, Mei C1, Xu R1, Chen H1.(PubMed)

(9) (Z)3,4,5,4'-trans-tetramethoxystilbene, a new analogue of resveratrol, inhibits gefitinb-resistant non-small celllung cancer via selectively elevating intracellular calcium level by Fan XX1, Yao XJ1, Xu SW1, Wong VK1, He JX2, Ding J3, Xue WW4, Mujtaba T5, Michelangeli F5, Huang M3, Huang J2, Xiao DK2, Jiang ZB1, Zhou YL1, Kin-Ting Kam R6, Liu L1, Lai-Han Leung E1.(PubMed)

(10) CArG-driven GADD45α activated by resveratrol inhibits lung cancer cells by Shi Q1, Geldenhuys W2, Sutariya V3, Bishayee A4, Patel I5, Bhatia D5.(PubMed)

(11) [Effects of wine polyphenols on cancer prevention].[Article in Spanish] by Sancho M1, Mach N2.(PubMed)

Most Common Diseases of Ages of 50 Plus - Musculoskeletal disorders (MSDs): Fibromyalgia Treatments In Traditional Chinese Medicine perspective

Kyle J. Norton(Scholar)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) is medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed(1).

                      Fibromyalgia

According to the American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia in the newly proposed criteria for the classification of fibromyalgia are 1) widespread pain in combination with 2) tenderness at 11 or more of the 18 specific tender point sites(a) as a result in responding to pressure.

The Treatment
C. In traditional Chinese medicine perspective
1. Acupuncture
In a study to test the hypothesis that acupuncture improves symptoms of fibromyalgia, researchers at the
Department of Anesthesiology, Mayo Clinic College of Medicine, showed that acupuncture significantly improved symptoms of fibromyalgia. Symptomatic improvement was not restricted to pain relief and was most significant for fatigue and anxiety(39).
2. Combination of acupuncture and cupping therapy
A combination of acupuncture and cupping therapy was better than conventional medications for reducing pain (MD, -1.66; 95% CI, -2.14 to -1.19; p < 0.00001; I(2) = 0%), and for improving depression scores with related to FM (MD, -4.92; 95% CI, -6.49 to -3.34; p < 0.00001; I(2) = 32%). Other individual trials demonstrated positive effects of Chinese herbal medicine on pain reduction compared with conventional medications. There were no serious adverse effects reported that were related to TCM therapies in these trials, according to the study by The Centre for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine(40).
2. Chinese herbal formulas
In a study of differentiation of Two TCM practitioners conducted baseline TCM diagnostic examinations on 56 women with FM, found that three primary TCM diagnoses were found in the population: Qi and Blood Deficiency(46.4%, CI 33.0% to 60.36%), Qi and Blood Stagnation (26.8%, CI 15.8% to 40.3%), and Liver Qi Stagnation (19.6%, CI 10.2% to 32.4%). Other study showed that syndromes were found to be important in FS include : 1)liver-Qi-stagnation 2) Yin and blood deficiency of the liver, 3) Yang-weakness of the spleen and kidney, 4) Yin-weakness of the kidney(41).
Dr. Shen in the article of Chinese Herbs & Chinese Medicine for Fibromyalgia, suggested the below formula to relieve pain
bai shao – 20%, qin jiao – 10%, du huo – 10%, yan hu sou – 10%, yu jin – 10%, tao ren – 10%, hong hua – 10%, mu dan pi – 10%, da zao – 5%, gan cao – 5%,
Basic Pain Formula; Take 3-4 grams (scoops), 3 times a day mixed with liquid or food.
Preferably on an empty stomach. (Should not be taken by pregnant women)(42).

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 MonthsBack to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(39) http://www.ncbi.nlm.nih.gov/pubmed/16770975
(40) http://www.ncbi.nlm.nih.gov/pubmed/20423209
(41) http://www.ncbi.nlm.nih.gov/pubmed/22026964
(42) http://www.drshen.com/herbsforfibromyalgia.htm

Most Common Diseases of Ages of 50 Plus - Musculoskeletal disorders (MSDs): Fibromyalgia Treatments In Herbal medicine perspective

Kyle J. Norton(Scholar)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) is medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed(1).

                      Fibromyalgia

According to the American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia in the newly proposed criteria for the classification of fibromyalgia are 1) widespread pain in combination with 2) tenderness at 11 or more of the 18 specific tender point sites(a) as a result in responding to pressure.

The Treatment
B. In Herbal medicine perspective
In the measurement of the prevalence of NHP use among adults in Canada, identify the most commonly used agents, and determine the socioeconomic, demographic, and health-related correlates of use, showed that Glucosamine, echinacea, and garlic were the most frequently used products. Women reported NHP use more frequently than men (11.5% vs. 7.1%). As compared to young adults, NHP use was about 50% higher in middle-aged and older Canadians. There were no associations with either income or education level. Several disease states were associated with a high prevalence of NHP use: respondents with fibromyalgia (23.3%), inflammatory bowel disease (17.4%), and urinary incontinence (16.8%) were most likely to be NHP users(35).
1. Ginkgo biloba
In an open, uncontrolled study was undertaken to measure the subjective effects of coenzyme Q10 combined with a Ginkgo biloba extract in volunteer subjects with clinically diagnosed fibromyalgia syndrome, researchers found that a progressive improvement in the quality-of-life scores was observed over the study period and at the end, the scores showed a significant difference from those at the start. This was matched by an improvement in self-rating with 64% claiming to be better and only 9% claiming to feel worse. Adverse effects were minor(36).
2. Harpagophytum procumbens (Devil’s claw), Salix alba (White willow bark), and Capsicum frutescens (Cayenne)
In a systematic review of randomized controlled trials to determine the effectiveness of herbal medicine compared with placebo, no intervention, or “standard/accepted/conventional treatments” for nonspecific low back pain, found that Harpagophytum procumbens (Devil’s claw), Salix alba (White willow bark), and Capsicum frutescens (Cayenne) seem to reduce pain more than placebo. Additional trials testing these herbal medicines against standard treatments will clarify their equivalence in terms of efficacy(37).
3. Cayenne is also known as Cayenne Pepper, a red, hot chili pepper, belonging to Capsicum annuum, the family Solanaceae, native to sub-tropical and tropical regions. It has been used in traditional medicine to increases metabolism, enhance circulatory system and stomach and the intestinal tract, adjust blood pressure, lower LDL cholesterol and triglycerides, treat frostbite, muscles, arthritis, rheumatism, low back pain, strains, sprains, bruises and neuralgia, etc.
the non-pungent pepper CH-19 Sweet and of hot red pepper activates the sympathetic nervous system (SNS) and enhances thermogenesis as effectively as hot red pepper, ant that the heat loss effect due to CH-19 Sweet is weaker than that due to hot red pepper. Furthermore, we found that intake of CH-19 Sweet does not affect systolic BP or HR, while hot red pepper transiently elevates them, according to the study of “Effects of CH-19 Sweet, a non-pungent cultivar of red pepper, on sympathetic nervous activity, body temperature, heart rate, and blood pressure in humans” by Hachiya S, Kawabata F, Ohnuki K, Inoue N, Yoneda H, Yazawa S, Fushiki T(38). 

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Sources
(a) http://www.ncbi.nlm.nih.gov/pubmed/2306288
(35) http://www.ncbi.nlm.nih.gov/pubmed/16921199
(36) http://www.ncbi.nlm.nih.gov/pubmed/12025528
(37) http://www.ncbi.nlm.nih.gov/pubmed/17202897 .
(38) http://www.ncbi.nlm.nih.gov/pubmed/17341828