Medical Advisor Journals

Friday, March 4, 2016

Most Common Diseases of elder: Lower respiratory tract infection (Respiratory Disease) – Pneumonia - Viral causes of Pneumonia

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Respiratory Disease

Respiratory Disease is defined as medical conditions, affecting the breathing organ and tissues including Inflammatory lung disease, Obstructive lung diseases, Restrictive lung diseases, Respiratory tract infections, trachea, bronchi, bronchioles, alveoli, the nerves and muscles breathing , etc,.

Lower respiratory tract infection

The lower respiratory tract infection are the infection consisting of the trachea (wind pipe), bronchial tubes, the bronchioles, and the lungs, including the bronchitis and pneumonia. According to The World Health Report 2004 – Changing History(1), in 2002 lower respiratory track infection were still the leading cause of deaths among all infectious diseases, and accounted for 3.9 million deaths worldwide and 6.9% of all deaths that year.

Pneumonia

Pneumonia is a condition of the inflammation of the lung as a result of infection, caused by bacteria, such as bacteria Streptococcus pneumoniae or influenza viruses in most cases. Fungi, such as Pneumocystis jiroveci, certain medication such as PPI Stomach Acid Drugs and other conditions such as impaired immune systems can also induced the disease.

The Causes

Viral causes of Pneumonia
1. Human bocavirus (HBoV)
According to the study of the clinical characteristics of human bocavirus (HBoV) infection in children, found that Among 843 cases, 90 were HboV positive (10.7%), 131 were respiratory syncytial virus (RSV) positive (15.5%), 117 were influenza virus positive (13.9%), 84 were parainfluenza virus positive (10.0%), 55 were rhinovirus positive (6.5%), 48 were coronavirus positive (5.7%), and 33 were human metapneumovirus positive (3.7%). Of the 90 HBoV infected patients, 45 (50%) showed a co-infection with other respiratory tract viruses. Among them, 33 were infected with one other type of virus (37%), 11 (12%) were infected with two other types of virus, and 1 case (1%) was infected with other three viruses. The HBoV positive rate in children with wheezing was significantly higher than those without wheezing (17.0% vs 9.2%; P<0.01)(8).
2. Legionnaires’ disease or HPIV 3
According to the study by Infectious Disease Division, Winthrop-University Hospital, the most common mimics of H1N1 pneumonia are Legionnaires’ disease or HPIV 3 in adults, and metapneumovirus or respiratory syncytial virus in children(9).
3. Human metapneumovirus
Human metapneumovirus (hMPV) is a newly identified paramyxovirus causing lower respiratory tract infections (LRTI). According to the strudy by School of Medicine, DPMSC, University of Udine, Italy, during a 15-month study period, 124 children were admitted due to presumptive CAP and, in 116 of them, CAP was radiologically confirmed that hMPV caused 0% to 17.5% of LRTI cases in children in the mini-review. The figure was about 5% in the present and in the only earlier paediatric CAP study. Thus, hMPV is a real but rare cause of paediatric CAP, although seroconversion to hMPV in most children takes place in early childhood(10).
4. Adenovirus
Adenovirus is a frequent cause of mild self-limiting upper respiratory tract infection, gastroenteritis, and conjunctivitis in infants and young children. There is a report of a case of severe adenovirus pneumonia in a young immunocompetent male who presented with sudden onset respiratory distress that progressed rapidly to respiratory failure and made a successful recovery on supportive measures. Systematic review of the literature identified 14 cases of severe adenovirus pneumonia (defined as respiratory failure requiring ventilatory support at any point during the course of illness) in otherwise healthy immunocompetent adults both in epidemic and community settings(11).
5. Acute respiratory distress syndrome (ARDS)
According to the study by Department of Medicine, University of Manitoba, H1N1 2009 has emerged as an important cause of ARDS in 2009-2010(12).
6. Other virus
Pleural effusion (PE), a complication of community-acquired pneumonia (CAP), is usually attributed to a bacterial infection. According to the study by Federal University of Bahia School of Medicine, found that in the study bacterial and viral infections among 277 children hospitalized with CAP, among these children 206 (74%) had radiographic confirmation, of whom 25 (12%) had PE. The aetiology was established in 18 (72%) PE cases: bacterial (n = 5; 28%), viral (n = 9; 50%), and viral-bacterial (n = 4; 22%) infections were found. Infection by rhinovirus (n = 3), enterovirus,Streptococcus pneumoniae (n = 2 each), Haemophilus influenzae,Moraxella catarrhalis, Mycoplasma pneumoniae, influenza A virus, andrespiratory syncytial virus (RSV) (n = 1 each) were detected as probable sole infections. Parainfluenza virus 1/3 + influenza A virus and RSV + influenza A virus (n = 1 each) were identified as mixed viral-viral infections(13).
5. Etc.

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) http://www.who.int/whr/2004/en/
(8) http://www.ncbi.nlm.nih.gov/pubmed/7839256
(9) http://www.ncbi.nlm.nih.gov/pubmed/20888645
(10) http://www.ncbi.nlm.nih.gov/pubmed/18618373
(11) http://www.ncbi.nlm.nih.gov/pubmed/18030505
(12) http://www.ncbi.nlm.nih.gov/pubmed/21157318
(13) http://www.ncbi.nlm.nih.gov/pubmed/23286738

Thursday, March 3, 2016

The Curable Smoothie of Green tea, Orange and Apple for Reduced Risk and Treatment of Cirrhosis back by Respectable Institutions

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for reduced risk and Treatment of idiopathic pulmonary fibrosis
Yield: 2 servings (about 8 ounces each)
1 cup tomato
1/2 cup grape
1 cup green tea drink (Make from 4 grams of green tea, and a cup of hot water lipped for 5 minutes. Set aside for cooling to room temperature)

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed. Add more green tea drink if needed
3. Serve immediately

The finding the natural ingredients for treatment of Cirrhosis considered as a dream of many scientist to replace the long usage adverse effect of conventional medicine . Unfortunately, many compounds found effective in initial studying failed to confirm the potential in large sample size and multi center.

Cirrhosis is a condition of irreversible scarring liver as a result of liver tissue by fibrosis due to final phase of chronic liver diseases of that can lead to poor function of the liver and liver failure. According to the statistics, Number of discharges with chronic liver disease or cirrhosis as the first-listed diagnosis: 101,000 in 2009 and Deaths per 100,000 population: 10.3 in 2010(1). Hepatitis B infection cause of the disease is very prevalent in South-East Asia.

According to the studies reported by some respectable institutions, Green tea may process the anti Cirrhosis effects through expression antixiodant effects. Green tea contains more amount of antioxidants than any drinks or food with the same volume, and is the leaves of Camellia sinensis, undergone minimal oxidation during processing, originated from China. .

According to the study lead by Dr. Safer AM, Green Tea Extract (GTE) encapsulated into Chitosan Nanoparticles (CS-NPs) removed all the extracellular collagen caused by CCl4, a ligand for the primary human immunodeficiency virus type 1 (HIV-1) in the hepatic fibrosis rat liver(2).

In animal model, Chitosan Nano-Encapsulated Green Tea expressed the healing ratio of heals nearly 25% of the sub-cellular area infected with hepatic fibrosis(3),

In the study of liver disease with green tea consumption, by searching the data bases of PubMed, CNKI, Wanfang and Weipu, Zhujiang Hospital of Southern Medical University Guangzhou firmly suggested the effectiveness of green tea in reduced risk of liver disease. However, more long term randomized clinical trials are needed to comprehensively evaluate the health benefits(4).

Naringenin, an phytochemical found in Citrus fruits, including orange attenuated the expression of liver fibrosis by exhibiting antioxidant and anti-inflammatory activities(5).

According to the Annamalai University, application of naringenin promoted the expression of therapeutic potential in the abatement of ethanol-induced hepatotoxicity by reduced the toxic levels, including serum aspartate and alanine transaminases, gamma-glutamyl transpeptidase, tissue thiobarbituric acid reactive substances(6).

Furthermore, According to dr. Hermenean A and research team at the Vasile Goldis Western University of Arad, the flavonoid naringenin (NGN), exerted antioxidant and hepatoprotective effects against injuries induced by CCl4, a natural ligand for the primary human immunodeficiency virus type 1 (HIV-1)(7).

Flavonoids, a group of plant phytochemicals found abundantly in apple may consist a numbers of health benefit through its effects in cell signalling pathways and antioxidant activity. According to the Chinese study, flavonoids, attenuate the risk of thioacetamide-induced hepatic fibrosis through mechanism related to the down-regulation of the protein expressions of TGF-β1 in controlling the expression of proliferation, differentiation, and Caspase-3 in cell apoptosis(8).
The phytochemical , flavonoids found in the the extracts of pomegranate peels (EPP) and seeds (EPS) also exerted the protective effects against liver fibrosis induced by CCl4, through restored the decreased superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) activities and inhibited the formation of lipid peroxidized products(9).
Dr. Yuan LP and colleagues at the College of Pharmacy, Anhui Medical University said,"(the) total flavonoids of Bidens bipinnata L.b was able to ameliorate liver injury and protect rats from CCl4-induced liver fibrosisby suppressing oxidative stress" through " inhibiting the induction of NF-kappaB (proinflammatory signaling pathway) on hepatic stellate cell activation and the expression of TGF-beta1 in controlling cells proliferation, differentiation"(10).

The combined ingredient found in green tea, orange and apple may contribute to further investigation of therapeutic natural ingredients for reduced risk and treatment of Cirrhosis .
People who are at increased risk of Cirrhosis due to family history, genetic mutation,... should drink at least one serving daily and people with Cirrhosis should drink as much as they can, depending to digestive toleration.

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

References

(1) Center for Diseases control and Prevention(CDC)

(2) Effect of Green Tea Extract Encapsulated Into Chitosan Nanoparticles on Hepatic Fibrosis Collagen Fibers Assessed by Atomic Force Microscopy in Rat Hepatic Fibrosis Model by Safer AM, Hanafy NA, Bharali DJ, Cui H, Mousa SA.(PubMed)

(3) Quantification of the Healing Effect in Hepatic Fibrosis Induced by Chitosan Nano-Encapsulated Green Tea in Rat Model by Safer AM, Sen A, Hanafy NA, Mousa SA.(PubMed)

(4) The effect of green tea intake on risk of liver disease: a meta analysis by Yin X1, Yang J2, Li T3, Song L4, Han T5, Yang M1, Liao H1, He J1, Zhong X1.(PubMed)

(5) Naringenin ameliorates daunorubicin induced nephrotoxicity by mitigating AT1R, ERK1/2-NFκB p65 mediated inflammation by Karuppagounder V1, Arumugam S1, Thandavarayan RA2, Pitchaimani V1, Sreedhar R1, Afrin R1, Harima M1, Suzuki H1, Suzuki K3, Nakamura M4, Ueno K5,Watanabe K6.(PubMed)

(6) Potential beneficial effect of naringenin on lipid peroxidation and antioxidant status in rats with ethanol-induced hepatotoxicity by Jayaraman J1, Veerappan M, Namasivayam N.(PubMed)

(7) Antioxidant and hepatoprotective effects of naringenin and its β-cyclodextrin formulation in mice intoxicated with carbon tetrachloride: a comparative study by Hermenean A1, Ardelean A, Stan M, Hadaruga N, Mihali CV, Costache M, Dinischiotu A.(PubMed)

(8) [Inhibitory effect of flavonoids from Glycyrrhiza uralensis on expressions of TGF-β1 and Caspase-3 in thioacetamide-induced hepatic fibrosis in rats].[Article in Chinese] by Jing J, Zhao JY, Hua B, Xue MQ, Zhu YF, Liu G, Wang YH, Peng XD.(PubMed)

(9) Protective effects of extracts from Pomegranate peels and seeds on liver fibrosis induced by carbon tetrachloride in rats by Wei XL1,2, Fang RT3, Yang YH4, Bi XY1, Ren GX2, Luo AL2, Zhao M5, Zang WJ6.(PubMed)

(10) Protective effects of total flavonoids of Bidens bipinnata L. against carbon tetrachloride-induced liver fibrosis in rats by Yuan LP1, Chen FH, Ling L, Bo H, Chen ZW, Li F, Zhong MM, Xia LJ.(PubMed)

The Smoothie of Sweet Potato, Orange and Sunflower Seed for Reduced Risk and Treatment of Endometriosis

Endometriosis is a condition of endometrial tissues grown outside the Due to its reaction to hormone signals of the monthly menstrual cycle, building up tissues, breaking it and eliminating it through menstrual period, endometriosis also cause severe pelvic pain.

Recent studies suggested that scientist in some research centers have found the naturally potential ingredients of antioxidant supplementation in ameliorated endometriosis-associated symptoms, including vitamin C(1), E(1) and A(2).

Sweet potato is a large, starchy, sweet tasting tuberous roots vegetable, genus Ipomoea, belongings to the family Convolvulaceae. The root vegetable contains a highest amount of vitamin A in comparison to other foods in the same content,

According to the joint study lead by the University of Maryland School of Pharmacy, the impairment of retinoic acid biosynthesis involved in the transport of retinol (vitamin A alcohol) from the liver storage site to peripheral tissue.is associated to the development of human and murine endometriosis(3).

Dr. Sokalska A and research team at the University of California said, " the expression of the key protein regulating the uptake of retinol (STRA6) and the expression of apoptosis-promoting CRABP2,....may contribute to cooperative apoptosis-inducing effects of simvastatin and RA and support the examination of these compounds in the treatment of endometriosis" in the investigation of the effects of simvastatin on retinoic acid system against endometriosis(4).

Vitamin C, alangeso known as L-ascorbate, a water soluble vitamin with a chemical structure formula of C6H6O6 found abundantly in orange is best known for it's antioxidant property in strengthening the immune system against any inflammatory diseases, including endometriosis(1).
In experimental endometriotic cysts study, vitamin C in dose-dependent ameliorated the volumes and weights of the endometriotic cysts(5).

According to the Instituto Nacional de Perinatología, regular intake of vitamin C and E, lowered oxidative stress marker levels in attenuated the symptoms of endometriosis(6).

In fact, intake of vitamin C and vitamin E expressed a a positive association between the pathology development and the lipoperoxidation status in women with endometriosis(7).

Vitamin E, best known for its powerful antioxidant property a fat soluble vitamin found abundantly
in sunflower seed. According to the Maternal and Child Health Hospital of Guangdong Province, intake of vitamin E in patient with endonetriosis decreased oxidative stress, as well as improved mature oocyte rates and fertilization rates(8).

In fact, regular intake of "vitamin E from food sources are found inversely related to endometriosis risk" Dr. Darling AM and colleagues at the joint study lead by the Harvard School of Public Health said.
The discovery of combined ingredients of Sweet Potato, Orange and Sunflower Seed may act as a cornerstone for induction of further investigation of the effectiveness of natural smoothie in reduced risk and treatment of Sweet Potato, Orange and Sunflower Seed.

Women who are at increased risk of Sweet Potato, Orange and Sunflower Seed due to family history, ... may drink one or 2 servings a day, women with endometriosis should drink as much as they can depending to the digestive alternation.
Life style and dietary pattern change are recommended.

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

References,

(1) Antioxidant supplementation reduces endometriosis-related pelvic pain in humans by Santanam N1, Kavtaradze N, Murphy A, Dominguez C, Parthasarathy S.(PubMed)

(2) Women with endometriosis improved their peripheral antioxidant markers after the application of a high antioxidant diet by Mier-Cabrera J1, Aburto-Soto T, Burrola-Méndez S, Jiménez-Zamudio L, Tolentino MC, Casanueva E, Hernández-Guerrero C.(PubMed)

(3) Retinoic acid biosynthesis is impaired in human and murine endometriosis by Pierzchalski K1, Taylor RN2, Nezhat C3, Jones JW1, Napoli JL4, Yang G5, Kane MA6, Sidell N7(PubMed)

(4) Effects of simvastatin on retinoic acid system in primary human endometrial stromal cells and in a chimeric model of human endometriosis by Sokalska A1, Anderson M, Villanueva J, Ortega I, Bruner-Tran KL, Osteen KG, Duleba AJ.(PubMed)

(5) Effect of vitamin C on the growth of experimentally induced endometriotic cysts by Durak Y1, Kokcu A, Kefeli M, Bildircin D, Çelik H, Alper T.(PubMed)
(6) Effect of vitamins C and E supplementation on peripheral oxidative stress markers and pregnancy rate in women with endometriosis. by Mier-Cabrera J1, Genera-García M, De la Jara-Díaz J, Perichart-Perera O, Vadillo-Ortega F, Hernández-Guerrero C.(PubMed)
(7) [Endometriosis and deficient intake of antioxidants molecules related to peripheral and peritoneal oxidative stress].[Article in Spanish]by Hernández Guerrero CA1, Bujalil Montenegro L, de la Jara Díaz J, Mier Cabrera J, Bouchán Valencia P.(PubMed)
(8) Oxidative stress impairs oocyte quality and melatonin protects oocytes from free radical damage and improves fertilization rate. by Tamura H1, Takasaki A, Miwa I, Taniguchi K, Maekawa R, Asada H, Taketani T, Matsuoka A, Yamagata Y, Shimamura K, Morioka H,Ishikawa H, Reiter RJ, Sugino N.(PubMed)
(9) A prospective cohort study of Vitamins B, C, E, and multivitamin intake and endometriosis. by Darling AM1, Chavarro JE2, Malspeis S3, Harris HR4, Missmer SA5.(PubMed)

Most Common Diseases of elder: Lower respiratory tract infection (Respiratory Disease) – Pneumonia - Bacterial causes of Pneumonia

Pneumonia

The Causes
Bacterial causes of Pneumonia
1. Atypical Bacteria
‘Atypical’ bacteria, especially C. pneumoniae (Legionella pneumophila serogroup 1, C. pneumoniae, Chlamydia psittaci, Coxiella burnetii (phase-2 antigen) and Mycoplasma pneumoniae (IgG and IgM)), are a common cause of community-acquired pneumonia in adults in South Africa. In the study to assess the proportion of cases of community-acquired pneumonia caused by ‘atypical’ bacteria, including the recently discovered Chlamydia pneumoniae, and to compare the clinical, radiographic and laboratory features of patients with and without ‘atypical’ bacteria, showed that in the he records of 4 patients could not be traced and 17 patients did not fulfil the inclusion criteria. Thirty-two of these 92 patients (35.9%) were found to be infected with ‘atypical’ bacteria. The two most common organisms were C. pneumoniae (20.7%) and L. pneumophila (8.7%)(14).
2. Streptococcus pneumoniae and Staphylococcus aureus
Pneumonia is an infection of the lower respiratory tract caused by microbial pathogens. Two such pathogens, Streptococcus pneumoniae and Staphylococcus aureus, are the most common causes of community-acquired and hospital-acquired pneumonia respectively(15).
3. Bacillus anthraxis
There is a report of a case of rapidly progressive, fatal, anthrax-like pneumonia and the overwhelming infection caused by a Bacillus species of uncertain provenance in a patient residing in rural Texas, according to teh study by Department of Pathology and Laboratory Medicine, The Methodist Hospital System(16).
4. Coxiella burnetii
Coxiella burnetii, the causative agent of Q fever is an intracellular bacterium and a potential weapon for bioterrorism. The widespread throughout the world zoonosis is manifested clinically as a self-limited febrile illness, as pneumonia (acute Q fever) or as a chronic illness with endocarditis being its major complication(17).
5. Legionella pneumophila
Legionella pneumophila, the causative agent of Legionnaires’ disease is a facultative intracellular bacterium, which in the course of human infection multiplies in lung macrophages predominantly manifesting as pneumonia(18).
6. Etc.

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

The Curable Smoothie of Green Tea and Strawberry for Reduced Risk and Treatment of Pulmonary fibrosis

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for reduced risk and Treatment of pulmonary fibrosis
Yield: 2 servings (about 8 ounces each)
1 1/2 cups strawberry
1 cup green tea drink (Make from 4 grams of green tea, and a cup of hot water lipped for 5 minutes. Set aside for cooling to room temperature)

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed. Add more green tea drink if needed
3. Serve immediately

The finding the natural ingredients for treatment of pulmonary fibrosis is considered as a dream of many scientist to replace the long usage adverse effect of conventional medicine to other organs in the body. Unfortunately, many compounds found effective in initial studying failed to confirm the potential in large sample size and multi center.

Pulmonary fibrosis is a lung disease caused by damaged and scarred.in lung tissues, leading to serious breathing problems. According to statistic, the most common risk factors of risk factors of pulmonary fibrosis include occupational and environmental exposures, tobacco smoking, gastroesophageal reflux, and genetic factors(1), effecting 200,000 people in the US with 48,000 new cases are diagnosed each year.

According to scientist in some respectable institutions, phytochemicals epigallocatechin-3-gallate

in green tea extract(2) and gallic acid isolated from strawberry may process an effectively potential as therapeutic agents for reduced risk and treatment of pulmonary fibrosis.

Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Due to its commercial values and health effects, green tea now has been cultivated all over the world in suitable climate. According to the joint study lead by the Wuhan University, epigallocatechin-3-gallate inhibited pulmonary fibrosis through its antioxidant effects in reduced the expression numerous proinflammatory cytokines(2).

According to Dr. Sriram N and colleagues at the University of Madras, the green tea phytochemical
also protected against the early onset of pulmonary fibrosis through ameliorated bleomycin-induced glycoconjugates, lysosomal hydrolases and ultrastructural changes in the lungs of Wistar rats(3).

Furthermore, Epigallocatechin-3-gallate (EGCG), a polyphenol and a major component of green tea reduced the expression of oxidative stress causes of imbalance between radical-generating and radical scavenging systems in the pathogenesis of pulmonary fibrosis(4).

Gallic acid, a phytochemical in the class of Phenolic acids, found abundantly in strawberries, also exhibited anti pulmonary fibrosis through demonstartion of its antioxidant properties in attenuated oxidative damage and fibrosis induced by Bleomycin (BLM)(5).

According to the Nanhua University study, garlic acid induce apoptosis in tumor cell lines and lung fibroblasts, through anti ROS as a result of c-Jun N-terminal kinases (JNKs) inflammatory signals and cell cycle division of p53 activation, and cell death pathways(6)(7).

Dr. Chuang CY and colleagues at the Chung Shan Medical University said, "Targeting fibroblasts with apoptotic agents represents a major therapeutic intervention for debilitating IPF" and " Gallic acid (3,4,5-trihydroxybenzoic acid), a naturally occurring plant phenol, has been reported to induce apoptosis in tumor cell lines and renal fibroblasts"(8).

The combined epigallocatechin gallate (EGCG) and gallic acid, found in green tea, and strawberry may contribute to further investigation of therapeutic natural ingredients for reduced risk and treatment of Pulmonary fibrosis.
People who are at increased risk of Pulmonary fibrosis due to family history, genetic mutation,... should drink at least one serving daily and people with Pulmonary fibrosis. should drink as much as they can, depending to digestive toleration.

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

References
(1) Epidemiology of idiopathic pulmonary fibrosi by Brett Ley and Harold R Collard(PubMed)

(2) The green tea extract epigallocatechin-3-gallate inhibits irradiation-induced pulmonary fibrosis in adult rats by You H1, Wei L2, Sun WL1, Wang L3, Yang ZL4, Liu Y4, Zheng K5, Wang Y6, Zhang WJ1.(PubMed)

(3) Epigallocatechin-3-gallate exhibits anti-fibrotic effect by attenuating bleomycin-induced glycoconjugates, lysosomal hydrolases and ultrastructural changes in rat model pulmonary fibrosis by Sriram N1, Kalayarasan S, Sudhandiran G.(PubMed)

(4) Enhancement of antioxidant defense system by epigallocatechin-3-gallate during bleomycin induced experimental pulmonary fibrosis by Sriram N1, Kalayarasan S, Sudhandiran G.(PubMed)
(5) Protective effect of gallic acid against bleomycin-induced pulmonary fibrosis in rats by Nikbakht J1, Hemmati AA1, Arzi A1, Mansouri MT2, Rezaie A3, Ghafourian M4.(PubMed)
(6) Gallic Acid Induces a Reactive Oxygen Species-Provoked c-Jun NH2-Terminal Kinase-Dependent Apoptosis in Lung Fibroblasts by Chen CY1, Chen KC, Yang TY, Liu HC, Hsu SL.(PubMed)
(7) Gallic acid induces apoptosis of lung fibroblasts via a reactive oxygen species-dependent ataxia telangiectasia mutated-p53 activation pathway. by Chuang CY1, Liu HC, Wu LC, Chen CY, Chang JT, Hsu SL.(PubMed)
(8) Gallic acid induces apoptosis of lung fibroblasts via a reactive oxygen species-dependent ataxia telangiectasia mutated-p53 activation pathway by Chuang CY1, Liu HC, Wu LC, Chen CY, Chang JT, Hsu SL.(PubMed)

Most Common Diseases of elder: Lower respiratory tract infection (Respiratory Disease) – Pneumonia - The Risk Factors

Pneumonia

Pneumonia is a condition of the inflammation of the lung as a result of infection, caused by bacteria, such as bacteria Streptococcus pneumoniae or influenza viruses in most cases. Fungi, such as Pneumocystis jiroveci, certain medication such as PPI Stomach Acid Drugs and other conditions such as impaired immune systems can also induced the disease.

The Risk factors

1. In Hospitalization
If you are being hospitalized, you are at increased risk to acquire the diseases. According to the study by Shanghai Jiao Tong University School of Medicine, Shanghai, Klebsiella pneumoniae is a member of the family Enterobacteriaceae, opportunistic pathogens that are among the eight most prevalent infectious agents in hospitals. The emergence of multidrug-resistant strains of K. pneumoniae has became a public health problem globally(21).

2. Certain chronical conditions
a. Chronic obstructive pulmonary disease (COPD)
Patients with chronic obstructive pulmonary disease are at inscreased risk of Chlamydia pneumoniae.
There is a correlation between Chlamydia pneumonia (Cpn) infection and chronic obstructive pulmonary disease (COPD), according to the study by Department of Respiratory Medicine of People’s Hospital of Jiangyin(22).
b. Asthma
Asthma is a chronic inflammatory disease affecting the air way of the lung with recurring symptoms, such as wheezing, chest tightness, shortness of breath, and coughing. Of 18 controlled epidemiologic studies (over 4000 cases/controls), 15 found significant associations between Cpn infection and asthma using organism detection (polymerase chain reaction (PCR) testing (n = 2 studies) or fluorescent antigen testing (n = 1)), Cpn-specific secretory IgA (sIgA) antibody testing (n = 1), and/or specific serum IgE (n = 2), IgA (n = 4), IgG (n = 3) or other antibody criteria (n = 7). According to the studyby Dean Medical Center, Madison(23).
c. Cystic fibrosis
Cystic fibrosis (SIS-tik fi-BRO-sis), or CF, is an inherited disease of the secretory (
see-KREH-tor-ee) glands. Pulmonary infection with Pseudomonas aeruginosa and neutrophilic lung inflammation significantly contribute to morbidity and mortality in cystic fibrosis (CF), according to the study by St. John’s University College of Pharmacy and Allied Health Professions(24). d. Congestive heart failure (CHF) and diabetes
Congestive heart failure (CHF) is defined as a condition of that the heart’s function can enough oxgen to the body. According to the study of the estimation of the economic impact of community-acquired pneumonia (CAP) for adults with asthma, diabetes, chronic obstructive pulmonary disease (COPD) and congestive heart failure (CHF) by Dr. Polsky D, and research team, in adults with certain comorbid conditions have a higher risk of pneumonia than the overall population. If treatment of pneumonia is more costly in certain predictable situations, this would affect the value proposition of populations for pneumonia prevention(25).
e. Sickle cell anemia
Sickle cell anemia is defined as a codition of which the body produces abnormally shaped like a crescent or sickle red blood cells. Patient with sickle cell disease are at high risk of developing an acute infection of the pulmonary parenchyma called community-acquired pneumonia(26).
g. Bronchiectasis
There is a report of a case of a 76-year-old man with a community-acquired pneumonia, in whom both sputum samples and bronchial secretions obtained with bronchoscopic protected catheter brush grew pure culture of N. sicca with abundant polymorphonuclear neutrophils. Bronchiectasis underlying lesions were disclosed by computed tomography. N. sicca should be added to the list of commensal organisms able to cause pulmonary infection(27).
h. Inmune deficiency
Pneumocystis jiroveci pneumonia (PJP) is a potentially fatal fungal infection occurring in immunocompromised patients. There are a number of case reports in the literature, the only collagen vascular disease with an increased incidence of PJP is Wegener granulomatosis.(28).
g. Etc.

3. Smoking
Smoking increases the risk of hospitalization for pneumonia. Tobacco cessation is likely important in reducing hospital admissions for pneumonia, but its benefit depends on duration of smoking cessation and is likely attenuated in the presence of COPD., according to the study of 25,235 participants, whom are identified 6720 current, 13,625 former, and 4890 never smokers(29).

4. Heavy alcohol drinking
Regular moderate alcohol intake is not associated with increased risk of hospitalisation for pneumonia. High weekly alcohol consumption in males and infrequent heavy drinking in both sexes may increase pneumonia risk(30).
5. Enhanced drug users
Epidemic of severe Streptococcus pyogenes infections in injecting drug users in the UK, 2003-2004 were reported and injecting drug users (IDUs) presented with a wide range of clinical manifestations, including pneumonia(31).
6. Older age

Older ages are at the increased risk to develop as a result of weakened immune system.

7. New born and young children
New and under age children are at the increased risk to develop as a result of immature immune system.

8. Season related
According to the study included 243 patients, 64.6% men and 54.7% over the age of 65. The highest incidence of CAP was in the winter. Streptococcus pneumoniae was the most common causative agent for all seasons except in summer when the main agent was Legionella pneumophila. We observed a significant correlation between the lowest seasonal average temperature and pneumococcal etiology of CAP; inversely, with higher temperatures, Legionella pneumophila was more common. No etiological differences were found by season when related with environmental humidity(32).

9. Certain chemicals exposure
Hypersensitivity pneumonitis (HP) is an interstitial lung disease caused by the inhalation of organic substances and certain inorganic chemicals(33).

10. Travellers
According to the investigation of travel-associated morbidity in European travellers in 2009 in comparison with 2008, with a particular emphasis on emerging infectious diseases with the potential for introduction into Europe, respiratory illnesses, in particular pandemic A(H1N1) influenza, influenza-like syndromes, and tuberculosis, were also observed more frequently. A significant increase in reported dengue cases in 2009 as compared with 2008 was observed (n = 172, 2.7% vs. n = 131, 1.90%) (p 0.002). The numbers of malaria and chikungunya cases were also increasing, although not significantly. Two deaths were recorded: visceral leishmaniasis and sepsis in a Sudanese migrant, and Acinetobacter sp. pneumonia in a patient who had visited Spain(34).

11. Etc.

Wednesday, March 2, 2016

The Tasty Smoothie of Green Tea, Grape and Flax Seed for Reduced Risk and Treatment of Cystic Fibrosis

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for reduced risk and Treatment of cystic fibrosis
Yield: 2 serving (about 8 ounce each)
13/8 grape
1/8 cup flax seed
1 cup green tea drink (Make from 4 grams of green tea, and a cup of hot water lipped for 5 minutes. Set aside for cooling to room temperature)

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed. Add more green tea drink if needed
3. Serve immediately

The finding the natural ingredients for treatment of cystic fibrosis is considered as a dream of many scientist to replace the long usage adverse effect of conventional medicine to other organs in the body. Unfortunately, many compounds found effective in initial studying failed to confirm the potential in large sample size and multi center.

Cystic fibrosis is a genetic disease passing through the family affecting the body's epithelial cells. The genetic disease cause the building up of mucus of that may block the lungs and ducts and passageway, causing infection and breathing problem.
Recent discoveries from respectable institutions suggested that green tea(1), grape(4) and flax seed(7) exert theirs antioxidant effects through numerous mechanisms in reduced risk and treatment of cystic fibrosis. Epigallocatechin-3-gallate (EGCg), a green tea component exhibited against Stenotrophomonas maltophilia (Sm) isolates from cystic fibrosis (CF) patients, through significantly reduced Sm bacterial counts in an acute infection model(1) back by its anti microbial activities(2).

Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years used in traditional Chinese medicine for treatment of various diseases, including cancers and heart diseases.

Dr. Namkung W and the research team at the University of California, in the evaluated CaCC modulators showed that epicatechin, catechin, and malvidin-3-glucoside from green tea inhibited calcium-activated Cl(-) channel (CaCC) for treatment of cystic fibrosis(3).

Resveratrol, a phytochemical in the class of Stilbenoids, found abundantly in grape wine also exhibited anti Cystic fibrosis effects through ameliorate and modulated CFTR expression and localization for reduced risk of gene mutation causes of development of cystic fibrosis(4).

According to the Liaoning Normal University, two resveratrol oligomers found in from Chinese wild grapevine mimicked the function of transmembrane conductance regulator (CFTR) for treatment of cystic fibrosis(5).

Dr. Yu B and colleagues at the Liaoning Normal University, said, "resveratrol (RES) could potentiate cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel activity(of) two most common forms of CF-related mutation (deltaF508 and G551D-CFTR)"(6).

Omega 3 fatty acids, phytochemincals in the class of Lipids, found abundantly flax seed have shown to associate for reduced risk and treatment of Cystic fibrosis(7).
According to the Harvard Medical School, Massachusetts General Hospital, fatty acid alterations have been found in the blood and tissues of cystic fibrosis (CF) patients(10).

Dr. Oliver anmd Dr., Watson H. in the study of Omega-3 fatty acids for cystic fibrosis,
said, " regular omega-3 supplements may provide some benefits for people with cystic fibrosis with relatively few adverse effects."(8) through restoration of abnormal fatty acid profiles in patients with in cystic fibrosis(9).

The combined epigallocatechin gallate (EGCG), resveratrol and omega 3 fatty acids, found in green tea, grape and flax seed respectively may contribute to further investigation of therapeutic natural ingredients for reduced risk and treatment of cystic fibrosis.

People who are at increased risk of cystic fibrosis.due to family history, genetic mutation,... should drink at least one serving daily and people with cystic fibrosis. should drink as much as they can, depending to digestive toleration.

References

(1) Effects of green tea compound epigallocatechin-3-gallate against Stenotrophomonas maltophilia infection and biofilm by Vidigal PG1, Müsken M2, Becker KA3, Häussler S2, Wingender J4, Steinmann E5, Kehrmann J1, Gulbins E3, Buer J1, Rath PM1, Steinmann J1.(PubMed)

(2) Antimicrobial activity of the green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG) against clinical isolates of Stenotrophomonas maltophilia by Gordon NC1, Wareham DW.(PubMed)

(3) Inhibition of Ca2+-activated Cl- channels by gallotannins as a possible molecular basis for health benefits of red wine and green tea by Namkung W1, Thiagarajah JR, Phuan PW, Verkman AS.(PubMed)

(4) Resveratrol rescues cAMP-dependent anionic transport in the cystic fibrosis pancreatic cell line CFPAC1 by Hamdaoui N1, Baudoin-Legros M, Kelly M, Aissat A, Moriceau S, Vieu DL, Colas J, Fritsch J, Edelman A, Planelles G.(PubMed)

(5) Identification of resveratrol oligomers as inhibitors of cystic fibrosis transmembrane conductance regulator by high-throughput screening of natural products from Chinese medicinal plants by Zhang Y1, Yu B1, Sui Y2, Gao X3, Yang H1, Ma T2.(PubMed)

(6) Potentiation of mutant CFTR Cl- channel currents by the naturally occurring stilbene compound resveratrol by Yu B1, Zhang Y1, Sui Y2, Yang S1, Luan J1, Wang X1, Ma T1, Yang H1.(PubMed)

(7) Is there a case for n-3 fatty acid supplementation in cystic fibrosis? by Cawood AL1, Carroll MP, Wootton SA, Calder PC.(PubMed)

(8) Omega-3 fatty acids for cystic fibrosis by Oliver C1, Watson H.(PubMed)

(9) Is there a case for n-3 fatty acid supplementation in cystic fibrosis? by Cawood AL1, Carroll MP, Wootton SA, Calder PC.(PubMed)

(10) Fatty acid alterations and n-3 fatty acid supplementation in cystic fibrosis by Al-Turkmani MR1, Freedman SD, Laposata M.(PubMed)