Thursday, March 24, 2016

The Best Smoothie of Carrot and Sweet Potato and Low Fat Cow Milk for Prevention of Giving Birth to Low birth-weight babies

Kyle J. Norton(Scholar, master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for reduced risk and treatment of Low birth-weight babies
Yield: 2 serving (about 8 ounce each)
1 cup sweet potato
1/2  cup carrot
1 cup of low fat cow milk


1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately

The finding of a natural source for reduced risk and treatment of low birth-weight babies has encountered many obstacles, many ingredients showed initially the promising result in animal studies have not produced same potentials in large sample size and mutli centers human trials.

Low birth weight is a condition of a baby who was born below the weight of gestational age due to several reasons, including, the baby was born too soon, were small for gestational age, the poor health of the mother, nutritional deficiency, certain diseases, etc. According to the statistic of the
World health organization, globally, more than 20 million infants were born with low birth weight.

Prevalence of vitamin A E, and D deficiencies is found to associated to pre-eclampsia and lower birth-weight babies in a total of 607 VLBW and 300 term neonates(1).
Vitamin A, a fat soluble vitamin and found abundantly in carrot, is a bi-polar molecule formed by bonds between carbon and hydrogen.
Dr. Murguía-Peniche T, professor at the National Center for Child and Adolescent Health (CeASIA), said, Preterm and low birth weight infants have low levels of these nutrients and are at risk for developing detrimental health consequences associated with vitamin A and vitamin D deficiencies"(2).
The Haukeland University Hospital study suggested, In HIV-infected women, vitamin A supplementation enhanced birth weight and growth in infants. Overdosing should be avoided(3).

Vitamin E, found abundantly in sweet potato, best known for its powerful antioxidant property is a fat soluble vitamin and can be stored in our body. Pregnant women with vitamin E is connected to ivinggbirth of very low birth-weight babies(1),Dr, Shah RS and researchers at the M.S. University,said, "maternal vitamin E deficiency is one of the features associated with prematurity and intra-uterine growth retardation"(4).

Vitamin D, found in very few food but added to milk in 103-105 (IU) per cup is associated to reduced risk of giving birth of low birth-weight babies(1). 
According to the Iran University of Medical Sciences, maternal Vitamin D deficiency may increase the risk of low birth weight neonate, improving maternal vitamin D level could be beneficial on pregnancy outcome(5). In support of the above, St George Hospital, Gray Street, suggested, maternal vitamin D deficiency increased the risk of neonatal vitamin D deficiency and lower birth weight and is common among pregnant women; immigrant, veiled and dark skinned women(6).

The smoothie of Carrot and Sweet Potato and Low Fat Cow Milk may hold a key for further studies in production of effective natural ingredients for prevention of giving birth to low birth-weight babies without inducing adverse effects.
Women who are pregnant with vitamin A, E and D deficiency or due to family history, ... should drink at least one cup daily, depending to the digestive toleration.

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References
(1) VitaminA, E, and D deficiencies in tunisian very low birth weight neonates: prevalence and risk factors by Fares S1, Sethom MM1, Khouaja-Mokrani C2, Jabnoun S2, Feki M3, Kaabachi N1.(PubMed)
(2) Vitamin D, vitamin A, maternal-perinatal considerations: old concepts, new insights, new questions by Murguía-Peniche T1.(PubMed)
(3) Influence of mineral and vitamin supplements on pregnancy outcome by Hovdenak N1, Haram K.(PubMed))
(4) Vitamin E status of the newborn in relation to gestational age, birth weight and maternal vitamin E status. by Shah RS1, Rajalakshmi R, Bhatt RV, Hazra MN, Patel BC, Swamy NB, Patel TV.(PubMed)) Vitamin A status of the newborn in relation to gestational age, body weight, and maternal nutritional status.
Shah RS, Rajalakshmi R.(5) The Relationship between Maternal Vitamin D Deficiency and Low Birth Weight Neonates by Khalessi N1, Kalani M2, Araghi M1, Farahani Z3.(PubMed)

The Smoothie of Green tea, Orange and Grape for Prevention and Treatment of Renal Amyloidosis

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for prevention and treatment of Renal Amyloidosis  
Yield: 2 servings (about 8 ounces each)

1/2 cup orange
1 cup grape
1 cup green tea drink (Make from 4 grams of green tea, a slice of ginger and a cup of hot water lipped for 5 minutes, and let cool to room temperature)

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately

The finding of a natural source for treatment of Renal Amyloidosis  has been running into many obstacles, many ingredients showed initially with promising result in animal studies have not produced same potentials in large sample size and mutli centers human trials.

Recent studies back by well known institutions proposed, Green tea, Orange and Grape may be the next generation of natural ingredients for prevention and treatment of Reno Amyloidosis. 

 Renal Amyloidosis is a condition of kidney damage caused by deposited of amyloid, affecting kidney function in filtering wastes and breaking down proteins. According to the joint study led by the Tokushima University Graduate School, (-)-epigallocatechin-3-gallate (EGCG), a tea-derived flavanol, expressed anti Reno Amyloidosis effects by inhibited fibril formation and disaggregated fibrils preformed(1).
Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Because of their health benefits, they have been cultivated for commercial purposes all over the world. An observational study, suggested, green tea consumption is associated to amyloid fibril reduction, due to its (-)-epigallocatechin-3-gallate (EGCG) in significant decrease of left ventricular (LV) myocardial mass through stabilization of wild-type transthyretin amyloid cardiomyopathy (wtATTR-CM)(2).
Furthermore, the phytochemical isolated from greem tea also inhibited the progression of Reno Amyloidosis by modulating the rate of formation and structural properties of apolipoprotein C-II amyloid fibrils, the The University of Melbourne, Parkville insisted(3).

Resveratrol, a phytochemical in the class of Stilbenoids, found abundantly in grape and blueberry also inhibited the process of amyloid formation by the normally soluble hormone islet amyloid polypeptide (IAPP) which contributed to β-cell death in type 2 diabetes, according to the Stony Brook University(4).

Vitamin C, one of the powerful may benefit patients with amyloidosis, through its free radical scavenger activity(5). 
According to Dr. Ravid M and colleagues, in animal model, ascorbic acid partially restored the amyloid-degrading activity in dose-dependent manner(6).

The effectiveness of  Green tea, Orange and Grape may serve as cornerstones of pharmaceutical target for further studies in production of a potential medication for reduced risk, complications and treatment of Renal Amyloidosis with little or no adverse effects.

People who are at high risk of Renal Amyloidosis due to aging, weaken reno function... should drink at least one serving daily and women with Renal Amyloidosis  should drink no more than 4 servings daily, depending to digestive toleration.

Life style and diet pattern change are necessary.


References
(1) The polyphenol (-)-epigallocatechin-3-gallate prevents apoA-IIowa amyloidosis in vitro and protects human embryonic kidney 293 cells against amyloid cytotoxicity by Nakajima H1,2, Nishitsuji K1, Kawashima H3, Kuwabara K1,2, Mikawa S2, Uchimura K4, Akaji K3, Kashiwada Y5, Kobayashi N6, Saito H2,Sakashita N1.(PubMed)
(2) Green tea extract as a treatment for patients with wild-type transthyretin amyloidosis: an observational study by Siepen FA1, Bauer R1, Aurich M1, Buss SJ1, Steen H1, Altland K2, Katus HA1, Kristen AV1(PubMed)
(3) Fluphenazine·HCl and Epigallocatechin Gallate Modulate the Rate of Formation and Structural Properties of Apolipoprotein C-II Amyloid Fibrils by Zlatic CO1, Mao Y1, Ryan TM1, Mok YF1, Roberts BR1, Howlett GJ1, Griffin MD1.(PubMed)
(4) Mutational analysis of the ability of resveratrol to inhibit amyloid formation by islet amyloid polypeptide: critical evaluation of the importance of aromatic-inhibitor and histidine-inhibitor interactions by Tu LH1, Young LM, Wong AG, Ashcroft AE, Radford SE, Raleigh DP.(PubMed)
(6) Ascorbic acid-induced regression of amyloidosis in experimental animals by Ravid M, Chen B, Bernheim J, Kedar I.(PubMed)

Most Common Diseases of elder: Respiratory Pleural disease: Pleural effusion Treatment Caused by Pneumonia

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

                                          Respiratory Disease

Respiratory Disease is defined as medical conditions, affecting the breathing organ and tissues including Inflammatory lung disease, Obstructive lung diseases, Restrictive lung diseases, Respiratory tract infections, trachea, bronchi, bronchioles, alveoli, the nerves and muscles breathing , etc,.

                   Pleural disease: Pleural effusion

The pleura is a thin tissue covered by a layer of cells (mesothelial cells) that surrounds the lungs and lines the inside of the chest wall.
Pleural effusion is a condition of collection of fluid within the pleural cavity as a result of heart failure, bleeding (hemothorax), infections, excessive or decreased fluid volume, etc.

                       The Treatment

B.6.1. Treatments in conventional medicine perspective

Pleural effusion Caused by Pneumonia

Antibiotics are the mosst efective medication used to treat pneumonia. Other medication used conjucntion with antibiotics can be helpful in relieveing breathing and symptoms.
1. Antibiotics
Pneumonia caused by bacterial pathogens is the leading cause of mortality in children in low-income countries. In a review to identify effective antibiotics for community acquired pneumonia (CAP) in children by comparing various antibiotics, conducted by All India Institute of Medical Sciences, Ansari Nagar, indicated that for treatment of ambulatory patients with CAP, amoxycillin is an alternative to co-trimoxazole. With limited data on other antibiotics, co-amoxyclavulanic acid and cefpodoxime may be alternative second-line drugs. For severe pneumonia without hypoxia, oral amoxycillin may be an alternative to injectable penicillin in hospitalised children; however, for ambulatory treatment of such patients with oral antibiotics, more studies in community settings are required. For children hospitalised with severe and very severe CAP, penicillin/ampicillin plus gentamycin is superior to chloramphenicol. The other alternative drugs for such patients are ceftrioxone, levofloxacin, co-amoxyclavulanic acid and cefuroxime. Until more studies are available, these can be used as a second-line therapy(80).
Side effects are not limit to soft stools or diarrhea, mild stomach upset, etc.
2. Antivirals
Parainfluenza viruses affect the upper respiratory tract in all age group patients, in children aged 6 months to 3 years in particular. In the study to investigate the antiviral activity of Ingavirin (2-(imidazole-4-yl) ethanamide of pentandioic-1,5 acid) on a model of parainfluenza infection in Syrian hamsters, showed that the drug was shown to restrict the infectious process in animal lung tissue. This restriction manifested itself as reductions in the infectious titer of parainfluenza virus in the lung tissue, in the degree of pulmonary edema and tissue cell infiltration, and in virus-specific lesion of bronchial epithelial cells(81). Side effects are not limit to dizziness, fatigue, joint or muscle pain, headache, dry mouth, nausea, vomiting, loss of appetite, weight loss, insomnia, etc.
3. Other Supportive treatment to reduce symptoms, include
Fever and pain reducers such as aspirin, ibuprofen, naproxen or acetaminophen, etc. and cough medicine.

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Sources
(80) http://www.ncbi.nlm.nih.gov/pubmed/20238334
(81) http://www.ncbi.nlm.nih.gov/pubmed/22834146

Most Common Diseases of elder: Respiratory Pleural disease: Pleural effusion treatment Pleural effusion Caused by Congestive heart failure

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

                                          Respiratory Disease

Respiratory Disease is defined as medical conditions, affecting the breathing organ and tissues including Inflammatory lung disease, Obstructive lung diseases, Restrictive lung diseases, Respiratory tract infections, trachea, bronchi, bronchioles, alveoli, the nerves and muscles breathing , etc,.

                   Pleural disease: Pleural effusion

The pleura is a thin tissue covered by a layer of cells (mesothelial cells) that surrounds the lungs and lines the inside of the chest wall.
Pleural effusion is a condition of collection of fluid within the pleural cavity as a result of heart failure, bleeding (hemothorax), infections, excessive or decreased fluid volume, etc.

                                  The Treatment

B.6.1. Treatments in conventional medicine perspective
Treatments in conventional medicine perspective are depending to the underlined causes of the diseases with an aim to produce enough oxygen to the lung for the body to function.

Pleural effusion Caused by Congestive heart failure
Congestive heart failure is a condition of which the heart can’t pump enough blood to the body’s needs.
1. Nonsurgical treatment
1.1. Medication
The renin-angiotensin-aldosterone system is a well-established therapeutic target in the treatment of heart failure (HF). Substantial advances have been made with existing agents-angiotensin-converting enzyme (ACE) inhibitors, angiotensin II-receptor blockers (ARBs), and mineralocorticoid-receptor antagonists (MRAs)-and new data continue to emerge. According to teh study by the Medical Research Institute, University of Dundee, ARBs have been shown to be a beneficial alternative to ACE inhibitors in HFrEF, but their value when added to ACE inhibitors has been questioned. Upstream, direct renin blockade with aliskiren is being pursued in two large trials of HF, despite the premature halting of a third study. A substantial, unmet need remains in patients who have HF with preserved ejection fraction (HFpEF)(70).
2. Surgical treatments
2.1. Implantation of medical devices
a. Ventricular assist device (VAD).
Ventricular assist devices (VADs) have become an established therapeutic option for patients with end-stage heart failure. There is a reprot of six cases of VAD patients with clinical presentation of heart failure at different times after implantation and describe the mechanisms involved(71)
b. Cardiac resynchronization therapy (CRT) device (biventricular cardiac pacemaker).
In the study to elucidate the role of nuclear medicine imaging in the selection of candidates for cardiac resynchronization therapy (CRT) and in the evaluation of CRT effectiveness of a total of 28 patients (19 male and 9 female) with dilated cardiomyopathy (DCM) and heart failure (HF), found that all patients after CRT were divided into three groups. The first group included 10 patients with LVEF increased by more than 10 % (hyperresponders), the 2nd group included 11 patients with an increase in EF of more than 5 % but less than 10 % (responders) and third group consisted of 7 males whose LVEF remained unchanged or worsened compared with pre-operative values (nonresponders). Prior to CRT, no statistically significant differences were found between groups in hemodynamic parameters (EF, EDV, ESV, SV), intra- and interventricular dyssynchrony, as well as in the midsize of perfusion defects. Following long-term CRT, we found increase in LVEF and decrease in average size of perfusion defects in groups of hyperresponders and responders (p < 0.05). Results of SPECT with 123I-BMIPP, performed prior to CRT, showed that nonresponders had more pronounced disturbance of myocardial metabolism compared with the group of hyperresponders (20 vs. 14.7 %, p < 0.05)(72).
c. Internal cardiac defibrillator (ICD)
The Kalmar County Hospita, presented a case report and a selective review of pertinent literature retrieved by a PubMed search, including two up-to-date consensus documents. One-third to two-thirds of all ICD patients receive defibrillation therapy in the final days of their lives. Patients and their physicians rarely discuss deactivating the ICD. Automatic defibrillation therapy in a terminally ill patient with an ICD is painful and distressing, serves no medical purpose, and should be avoided. This issue should be discussed with ICD patients and their families. Institutions caring for terminally ill patients, as well as cardiology units where ICD patients are treated, should develop ethically and legally well-founded protocols for dealing with the question of ICD deactivation(73).
d. Rotary blood pumps
Rotary blood pumps are increasingly recognized as mainstream therapy for severely symptomatic heart failure. Carefully targeted refinements in patient selection and postoperative care have substantially reduced the adverse event burden. The Oxford University Hospitals Trust, John Radcliffe Hospital, suggested that It should focus on the choice between pump versus palliative care for the thousands of patients of all age groups who are judged ineligible for transplantation. Comprehensive healthcare systems must consider contemporary evidence and provide the most symptomatic of heart failure patients with effective care(74).
2.2. Surgical treatments
a. Heart valve repair or replacement.
The aim of the surgery is to relieve symptoms and improve quality of life of patients with congestive heart failure. In the study to o describe the pathophysiology of functional tricuspid regurgitation, summarize the current reports favoring a more aggressive approach toward tricuspid valve surgery, and discuss the emerging role of tricuspid valve annuloplasty with left ventricular assist device (LVAD) implantation, found that the presence of significant tricuspid regurgitation, whether in the context of mitral valve disease or heart failure, should no longer be treated with 'surgical abstention'. Whether the surgical correction of tricuspid regurgitation in left heart disease can definitively improve clinical outcomes should be addressed by prospective clinical trials(75). Other in the study to evaluate the long-term (5-year) safety and efficacy of mitral valve surgery with and without the CorCap cardiac support device (Acorn Cardiovascular, St Paul, Minn) in patients with dilated cardiomyopathy and New York Heart Association class II-IV heart failure, indicated that the data provide evidence supporting mitral valve repair in combination with the Acorn CorCap device for patients with nonischemic heart failure with severe left ventricular dysfunction who have been medically optimized yet remain symptomatic with significant mitral regurgitation(76).
b. Coronary bypass surgery
According to the study by the University of California, in the study to quantify the effects of a novel implantable hydrogel (Algisyl-LVR™) treatment in combination with coronary artery bypass grafting (i.e. Algisyl-LVR™+CABG) on both LV function and wall stress in heart failure patients. The data supportedthe novel concept that Algisyl-LVR™+CABG treatment leads to decreased myofiber stress, restored LV geometry and improved function(77)..
c. Heart transplant
Only for patients with severe congestive heart failure and other treatments have failed. According to the Ohio State University, Columbus, Avoidance of the clinical syndrome of acute right-sided heart failure after heart transplantation is, unfortunately, not possible. Clinical experience and the literature certainly suggest that a significant factor in the successful management of right ventricular (RV) failure is recipient selection. Moreover, threshold hemodynamic values beyond which RV failure is certain to occur and heart transplantation is contraindicated do not exist.Only through careful preoperative planning can this life-threatening condition be managed in the postoperative period(78).
d. Myectomy
Patient with blockage that occurs in hypertrophic cardiomyopathy may meed myectomy, if all medication have failed. There is a report of a 38-year-old woman of Hypertrophic Obstructive Cardiomyopathy, HOCM complicated with lung edema and cardiac arrest due to acute left heart failure. Intraventricular pressure gradient showed 125 mmHg in previous study, and echocardiogram demonstrated evidences suggestive of terminal-staged HOCM. After unsuccessful attempts of intravenous propranolol administration, emergency myectomy of left ventricular outflow tract was carried out. Postoperative course was uneventful, and intraventricular pressure gradient was relieved. The patient is now asymptomatic without medication after 1 years of operation. This case suggests that emergency myectomy may be a choice to relieve refractory congestive heart failure in patient with HOCM(79). 

Wednesday, March 23, 2016

The Smoothie of Green tea, Tomato and Blueberry for Prevention and Treatment of acute kidney failure in Adenine phosphoribosyltransferase

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for prevention and treatment of Adenine phosphoribosyltransferase deficiency(acute kidney failure)
Yield: 2 servings (about 8 ounces each)

1/2 cup Tomato
1 cup blueberry
1 cup green tea drink (Make from 4 grams of green tea, a slice of ginger and a cup of hot water lipped for 5 minutes, and let cool to room temperature)

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately

The finding of a natural source for treatment of Adenine phosphoribosyltransferase deficiency has been running into many obstacles, many ingredients showed initially with promising result in animal studies have not produced same potentials in large sample size and mutli centers human trials.

Adenine phosphoribosyltransferase deficiency is an inherited metabolic disorder associated to excessive production of 2,8-dihydroxyadenine (DHA), affecting the kidneys and urinary tract.
According to the study led by the University of Iceland, Progressive chronic kidney disease (CKD) and acute kidney injury (AKI) episodes are major features of APRT deficiency, whereas kidney stone is the most common presentation(12).

Acute kidney failure is the rapid (less than 2 days) loss of your kidney function in removed waste and  balanced fluids and electrolytes in your body. According to the Vrije Universiteit Brussel and Academic Hospital of the Vrije Universiteit Brussel, the progression of acute kidney failure also altered antioxidant defense in mouse adriamycin model(1), due to increased oxidative stress(2).

Recent studies back by well known institutions proposed, Green tea, Tomato and Blueberry may be the next generation of natural ingredients for prevention and treatment of acute kidney failure in Adenine phosphoribosyltransferase deficiency.

Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Due to its commercial values and health effects, green tea now has been cultivated all over the world in suitable climate. According to the study led by the Kyoto University Graduate School of Medicine, epigallocatechin-3-gallate (EGCG) is a major component of the polyphenolic fraction of green tea, ameliorated (Acute kidney failure) AKI in a cardiopulmonary bypass (CPB) model of diabetic rats through antioxidative properties(3).
In a small piglet model of extracorporeal circulation, the phytochemical also exhibited reno protective effects through its antioxidant, antiapoptotic and NO-scavenging properties(4).
Dr. Nasri H and professors led by the Isfahan University of Medical Sciences said," beneficial property of green tea, against renal toxicity of contrast media was observed. Green tea extract is an inexpensive, nontoxic, and effective treatment modality in individuals with a risk for acute kidney injury of contrast media"(5).

Resveratrol, a phytochemical in the class of Stilbenoids, found abundantly grape and blueberry also
exhibited anti acute kidney diseases by prevented endotoxin-induced disruption of endothelial cell permeability and inhibited inflammation of kidney tissue(6).
According to the University of Arkansas for Medical Sciences, resveratrol reduced the mortality rate of patients who develop acute kidney injury during sepsis through improvement in capillary perfusion and increased renal blood flow and the glomerular filtration rate without raising systemic pressure(7).
Dr. Kim DH and colleagues at the Chonbuk National University said, " Resveratrol expressed modulation of p53 (antigen), by SIRT1 (in several separated cellular functions), could be a possible target to attenuate cisplatin-induced kidney injury"(8).

Lycopene found abundantly in tomato, a derivative of carotenoids also expressed nephroprotective effect against cisplatin-induced acute kidney injury in rats, according to the Firat University(9).
The Federal University of Santa Maria study, proposed " lycopene could plays a beneficial role in acute renal failure against HgCl(2) toxicity by preventing lipid peroxidation and changes in the activity of delta-aminolevulinate dehydratase and antioxidant enzymes"(10).
Dr. Ateşşahin A and colleagues in the investigation of the possible protective role of antioxidant treatment with lycopene on cyclosporine A-induced nephrotoxicity using biochemical and histopatological approaches found that natural antioxidant lycopene might have protective effect against cyclosporine-induced nephrotoxicity and oxidative stress in rat(11).

The effectiveness of  Green tea, Tomato and Blueberry may serve as cornerstones of pharmaceutical target for further studies in production of a potential medication for reduced risk, complications and treatment of Acute kidney failure in Adenine phosphoribosyltransferase deficiencywith little or no adverse effects.

People who are at high risk of Acute kidney failure in Adenine phosphoribosyltransferase deficiency due to aging, weaken reno function... should drink at least one serving daily and women with Acute kidney failure in Adenine phosphoribosyltransferase deficiency should drink no more than 4 servings daily, depending to digestive toleration.

Life style and diet pattern change are necessary.


References
(1) Altered antioxidant defense in a mouse adriamycin model of glomerulosclerosis by Deman A1, Ceyssens B, Pauwels M, Zhang J, Houte KV, Verbeelen D, Van den Branden C.(PubMed)
(2) Increased oxidative stress in the mouse adriamycin model of glomerulosclerosis is accompanied by deposition of ferric iron and altered GGT activity in renal cortex by Ceyssens B1, Pauwels M, Meulemans B, Verbeelen D, Van den Branden C.(PubMed)
(3) Green Tea Polyphenol Prevents Diabetic Rats From Acute Kidney Injury After Cardiopulmonary Bypass by Funamoto M1, Masumoto H1, Takaori K2, Taki T1, Setozaki S1, Yamazaki K1, Minakata K1, Ikeda T3, Hyon SH4, Sakata R1.(PubMed)
(4) Reno-protective effects of epigallocatechingallate in a small piglet model of extracorporeal circulation by Twal M1, Kiefer P, Salameh A, Schnabel J, Ossmann S, von Salisch S, Krämer K, Sobiraj A, Kostelka M, Mohr FW, Dhein S.(PubMed)
(5) A biochemical study on ameliorative effect of green tea (Camellia sinensis) extract against contrast media induced acute kidney injury by Nasri H1, Ahmadi A2, Baradaran A3, Nasri P4, Hajian S4, Pour-Arian A4, Kohi G5, Rafieian-Kopaei M5.(PubMed)
(6) Resveratrol attenuates lipopolysaccharide-induced acute kidney injury by suppressing inflammation driven by macrophages by Chen L1, Yang S, Zumbrun EE, Guan H, Nagarkatti PS, Nagarkatti M.(PubMed)
(7) Resveratrol improves renal microcirculation, protects the tubular epithelium, and prolongs survival in a mouse model of sepsis-induced acute kidney injury by Holthoff JH1, Wang Z, Seely KA, Gokden N, Mayeux PR.(PubMed)
(8) SIRT1 activation by resveratrol ameliorates cisplatin-induced renal injury through deacetylation of p53 by Kim DH1, Jung YJ, Lee JE, Lee AS, Kang KP, Lee S, Park SK, Han MK, Lee SY, Ramkumar KM, Sung MJ, Kim W.(PubMed)
(9) Effect of lycopene against cisplatin-induced acute renal injury in rats: organic anion and cation transporters evaluation by Erman F1, Tuzcu M, Orhan C, Sahin N, Sahin K.(PubMed)
(10) Effect of lycopene on nephrotoxicity induced by mercuric chloride in rats by Augusti PR1, Conterato GM, Somacal S, Einsfeld L, Ramos AT, Hosomi FY, Graça DL, Emanuelli T.(PubMed)
(11) Lycopene, a carotenoid, attenuates cyclosporine-induced renal dysfunction and oxidative stress in rats by Ateşşahin A1, Ceribaşi AO, Yilmaz S.(PubMed)
(12) Kidney Disease in Adenine Phosphoribosyltransferase Deficiency. by Runolfsdottir HL1, Palsson R2, Agustsdottir IM3, Indridason OS4, Edvardsson VO5.(PubMed)

Most Common Diseases of elder: Respiratory Pleural disease: Pleural effusion - The Antioxidants

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

                                          Respiratory Disease

Respiratory Disease is defined as medical conditions, affecting the breathing organ and tissues including Inflammatory lung disease, Obstructive lung diseases, Restrictive lung diseases, Respiratory tract infections, trachea, bronchi, bronchioles, alveoli, the nerves and muscles breathing , etc,.

                   Pleural disease: Pleural effusion

The pleura is a thin tissue covered by a layer of cells (mesothelial cells) that surrounds the lungs and lines the inside of the chest wall.
Pleural effusion is a condition of collection of fluid within the pleural cavity as a result of heart failure, bleeding (hemothorax), infections, excessive or decreased fluid volume, etc.

                             The Antioxidants 

a. Matonon
In the study to evaluate the Oxidative stress of thirty-six consecutive patients with clinically stable moderate to very severe COPD (30 men; mean±S.D.=66.6±7.8yr) randomized to receive 3mg melatonin (N=18) or placebo for 3 months found that dyspnea was improved by melatonin (P=0.01), despite no significant changes in lung function or exercise capacity(65).

b. Resveratrol
According to the study bythe John Hunter Hospital, Newcastle, Antioxidants provide protection against the damaging effects of oxidative stress and thus may be useful in the management of inflammatory airways disease. Resveratrol, a polyphenol that demonstrates both antioxidative and anti-inflammatory functions, has been shown to improve outcomes in a variety of diseases(66).

c. Vitamin C
Although many epidemiological studies indicate protective effect of vitamin C against a variety of human malignancies its mechanism(s) of action is questionable, the presented results show that the part of its effect may be accomplished by mononuclear cells, as necessary participants in body defence. Namely, in a long-term in vitro assay we tested vitamin C influence on random migration ability of malignant pleural effusion mononuclears (PEM) obtained from breast cancer patients. Vitamin C in a dose- (50-500 micrograms) and time-dependent (4-44 h) manner inhibited PEM motility, suggesting that immobilization of cells in situ may contribute to its beneficial effect in human cancers, according to the Institute of Physiology, Medical Faculty, Belgrade(67)

d. L-Arginine
According to the study by Hôpital Cochin, Paris, in the study to assess the vNO generation in the course of two acute, non immune, inflammatory reactions (pleurisy induced by rat isologous serum and carrageenan) by means of nitrite measurement in pleural exudate from 0.5 to 24 h, indicated that NO release varied time-dependently, similarly for the two inflammatory reactions. A first, but transient, peak was reached in 30 min while a second peak, more sustained, began at the fourth hour and was maximum at the tenth. Kinetic evolution of NO release was consistent with activation, in a first step, of a constitutive NO synthase probably from endothelial origin (inhibited by 2-Methyl-2-Thiopseudourea sulfate but not by dexamethasone) and with activation, in a second wave, of inducible NOS from endothelial and exudative cells. NO release was potentiated by administration per os of L-Arginine and seems to be involved in the evolution of acute inflammatory reactions and oxygen metabolite production(68).

e. Other antioxidants
According to the study by the University of Rochester Medical Center, antioxidant and/or anti-inflammatory agents such as thiol molecules (glutathione and mucolytic drugs, such as N-acetyl-L-cysteine and N-acystelyn), dietary polyphenol (curcumin-diferuloylmethane, a principal component of turmeric), resveratrol (a flavanoid found in red wine), green tea (theophylline and epigallocatechin-3- gallate), ergothioneine (xanthine and peroxynitrite inhibitor), quercetin, erdosteine and carbocysteine lysine salt, have been reported to control NF-kappaB activation, regulation of glutathione biosynthesis genes, chromatin remodeling and hence inflammatory gene expression. Specific spin traps such as alpha-phenyl-N-tert-butyl nitrone, a catalytic antioxidant (ECSOD mimetic), manganese (III) meso-tetrakis (N,N’-diethyl-1,3-imidazolium-2-yl) porphyrin (AEOL 10150 and AEOL 10113), and a SOD mimetic M40419 have also been reported to inhibit cigarette smoke-induced inflammatory responses in vivo(69). 

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Tuesday, March 22, 2016

The Smoothie of Green Tea, Tomato and Blueberry for reduced risk and treatment of Acute kidney failure in Analgesic Nephropathy

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for prevention and treatment of  Acute kidney failure in Analgesic Nephropathy 
Yield: 2 servings (about 8 ounces each)

1/2 cup tomato
1 cup blueberry
1 cup green tea drink (Make from 4 grams of green tea, a slice of ginger and a cup of hot water lipped for 5 minutes, and let cool to room temperature)

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately

The finding of a natural source for treatment of Acute kidney failure in Analgesic Nephropathy has been running into many obstacles, many ingredients showed initially with promising result in animal studies have not produced same potentials in large sample size and mutli centers human trials.

Analgesic nephropathy is several kidney diseases caused by analgesic medications such as aspirin, phenacetin, and paracetamol.
Acute kidney failure is the rapid (less than 2 days) loss of your kidney function in removed waste and  balanced fluids and electrolytes in your body. According to the Vrije Universiteit Brussel and Academic Hospital of the Vrije Universiteit Brussel, the progression of acute kidney failure also altered antioxidant defense in mouse adriamycin model(1), due to increased oxidative stress(2).

Recent studies back by well known institutions proposed, Green tea, Olive and Grape Juice may be the next generation of natural ingredients for prevention and treatment of Acute kidney failure in Analgesic Nephropathy

Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Due to its commercial values and health effects, green tea now has been cultivated all over the world in suitable climate. According to the study led by the Kyoto University Graduate School of Medicine, epigallocatechin-3-gallate (EGCG) is a major component of the polyphenolic fraction of green tea, ameliorated (Acute kidney failure) AKI in a cardiopulmonary bypass (CPB) model of diabetic rats through antioxidative properties(3).
In a small piglet model of extracorporeal circulation, the phytochemical also exhibited reno protective effects through its antioxidant, antiapoptotic and NO-scavenging properties(4).
Dr. Nasri H and professors led by the Isfahan University of Medical Sciences said," beneficial property of green tea, against renal toxicity of contrast media was observed. Green tea extract is an inexpensive, nontoxic, and effective treatment modality in individuals with a risk for acute kidney injury of contrast media"(5).

Resveratrol, a phytochemical in the class of Stilbenoids, found abundantly grape and blueberry also
exhibited anti acute kidney diseases by prevented endotoxin-induced disruption of endothelial cell permeability and inhibited inflammation of kidney tissue(6).
According to the University of Arkansas for Medical Sciences, resveratrol reduced the mortality rate of patients who develop acute kidney injury during sepsis through improvement in capillary perfusion and increased renal blood flow and the glomerular filtration rate without raising systemic pressure(7).
Dr. Kim DH and colleagues at the Chonbuk National University said, " Resveratrol expressed modulation of p53 (antigen), by SIRT1 (in several separated cellular functions), could be a possible target to attenuate cisplatin-induced kidney injury"(8).

Lycopene found abundantly in tomato, a derivative of carotenoids also expressed nephroprotective effect against cisplatin-induced acute kidney injury in rats, according to the Firat University(9).
The Federal University of Santa Maria study, proposed " lycopene could plays a beneficial role in acute renal failure against HgCl(2) toxicity by preventing lipid peroxidation and changes in the activity of delta-aminolevulinate dehydratase and antioxidant enzymes"(10).
Dr. Ateşşahin A and colleagues in the investigation of the possible protective role of antioxidant treatment with lycopene on cyclosporine A-induced nephrotoxicity using biochemical and histopatological approaches found that natural antioxidant lycopene might have protective effect against cyclosporine-induced nephrotoxicity and oxidative stress in rat(11).

The effectiveness of  Green tea, Tomato and Blueberry may serve as cornerstones of pharmaceutical target for further studies in production of a potential medication for reduced risk, complications and treatment of Acute kidney failure in Analgesic Nephropathy with little or no adverse effects.

People who are at high risk of Acute kidney failure in Analgesic Nephropathy due to aging, weaken reno function... should drink at least one serving daily and women with Acute kidney failure in Analgesic Nephropathy should drink no more than 4 servings daily, depending to digestive toleration.

Life style and diet pattern change are necessary.


References
(1) Altered antioxidant defense in a mouse adriamycin model of glomerulosclerosis by Deman A1, Ceyssens B, Pauwels M, Zhang J, Houte KV, Verbeelen D, Van den Branden C.(PubMed)
(2) Increased oxidative stress in the mouse adriamycin model of glomerulosclerosis is accompanied by deposition of ferric iron and altered GGT activity in renal cortex by Ceyssens B1, Pauwels M, Meulemans B, Verbeelen D, Van den Branden C.(PubMed)
(3) Green Tea Polyphenol Prevents Diabetic Rats From Acute Kidney Injury After Cardiopulmonary Bypass by Funamoto M1, Masumoto H1, Takaori K2, Taki T1, Setozaki S1, Yamazaki K1, Minakata K1, Ikeda T3, Hyon SH4, Sakata R1.(PubMed)
(4) Reno-protective effects of epigallocatechingallate in a small piglet model of extracorporeal circulation by Twal M1, Kiefer P, Salameh A, Schnabel J, Ossmann S, von Salisch S, Krämer K, Sobiraj A, Kostelka M, Mohr FW, Dhein S.(PubMed)
(5) A biochemical study on ameliorative effect of green tea (Camellia sinensis) extract against contrast media induced acute kidney injury by Nasri H1, Ahmadi A2, Baradaran A3, Nasri P4, Hajian S4, Pour-Arian A4, Kohi G5, Rafieian-Kopaei M5.(PubMed)
(6) Resveratrol attenuates lipopolysaccharide-induced acute kidney injury by suppressing inflammation driven by macrophages by Chen L1, Yang S, Zumbrun EE, Guan H, Nagarkatti PS, Nagarkatti M.(PubMed)
(7) Resveratrol improves renal microcirculation, protects the tubular epithelium, and prolongs survival in a mouse model of sepsis-induced acute kidney injury by Holthoff JH1, Wang Z, Seely KA, Gokden N, Mayeux PR.(PubMed)
(8) SIRT1 activation by resveratrol ameliorates cisplatin-induced renal injury through deacetylation of p53 by Kim DH1, Jung YJ, Lee JE, Lee AS, Kang KP, Lee S, Park SK, Han MK, Lee SY, Ramkumar KM, Sung MJ, Kim W.(PubMed)
(9) Effect of lycopene against cisplatin-induced acute renal injury in rats: organic anion and cation transporters evaluation by Erman F1, Tuzcu M, Orhan C, Sahin N, Sahin K.(PubMed)
(10) Effect of lycopene on nephrotoxicity induced by mercuric chloride in rats by Augusti PR1, Conterato GM, Somacal S, Einsfeld L, Ramos AT, Hosomi FY, Graça DL, Emanuelli T.(PubMed)
(11) Lycopene, a carotenoid, attenuates cyclosporine-induced renal dysfunction and oxidative stress in rats by Ateşşahin A1, Ceribaşi AO, Yilmaz S.(PubMed)