Medical Advisor Journals

Saturday, April 9, 2016

Most Common Disease of 50plus: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Osteoarthritis: Life style Modification in alternative medicine

The Best Smoothie of Blueberry for Treatment of early stage of Breast Cancer: Lobular carcinoma in situ (LCIS)

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The finding the natural ingredients for treatment of Lobular carcinoma in situ (LCIS) is considered as a dream of many scientist to replace the long term usage adverse effect of conventional medicine to other organs in the body. Unfortunately, many compounds found effective in initial studying failed to confirm the potential in large sample size and multi center.

Lobular carcinoma in situ (LCIS) is a pre cancerous condition of abnormal cells formed in the lobules or milk glands in the breast not spreading to nearby tissues or beyond. Women with lobular carcinoma in situ (LCIS) are at 7 -11 times of increased risk of developed invasive breast cancer, according to American Cancer Society.

Since lobular carcinoma in situ (LCIS) is localized cancer with tendency to travel to distance from the tissue of originated, blueberry smoothie for reduced risk and treatment of Breast Cancer may also be effective for prevention of lobular carcinoma in situ (LCIS) to become cancerously.

The smoothie for reduced risk and Treatment of Lobular carcinoma in situ (LCIS), an early stage of breast cancer
Yield: 2 serving (about 8 ounce each)
1 1/2 cups Blueberries
1 cup rice milk
4-6 ice cubes

1. Place all the ingredients in a blender.
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately.

The dream of finding of a natural ingredient for replacement of serious side effects of chemotherapy for treatment of breast caner has been extremely difficult, probably due to physical differences in testing subjects.

Breast cancer (malignant breast neoplasm) is a cancer originated in the tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma).

In 2010, over 250,000 new cases of breast cancer were diagnosed in women in the U.S. alone and the risk of getting invasive breast cancer during life time of a women is 1/8.

Blueberry, a flower plant, belong to the family Eriaceae and native to Northern America contains several essential phytochemicals and nutrients, including, lutein and zeaxanthin, zinc, potassium, phosphorus, iron, calcium and vitamins.

Blueberry or whole blueberry powder may hold a key for reduced risk breast cancer and for treatment of the diseases. Recent studies insisted that intake of the fruits and the fruit products showed to the improve the survival rate of women with breast cancer.

In estrogen-mediated breast cancer, blueberry-supplemented diet protect women against breast cancer induced by 17β-estradiol (E2)-mediated mammary tumorigenesis(breast cancer)(1) in animals received 5% blueberry diet, either 2 weeks prior to or 12 weeks study.Dr. Ravoori S and the research team at the University of Louisville suggested, the effectiveness of blue berry for treatment of breast cancer may be a result of the exhibition of its phytochemicals reducing mammary tissue proliferation and tumor burden, tumor latency(2).

In fact the intake of berries reduced significantly mammary tumor incidence (10-30%) by suppressing the levels of E(2) to prevent the early onset of E(2) breast cancer(3).
Dr. Aiyer HS and Gupta RC. said, blueberries and other berries promote anti proliferation and apoptosis of breast cancer cell is due its effects in modulating enzymes of estrogen metabolism.

In breast cancer cell lines MCF7 and MDA-MB-231, pterostilbene, a phytochemical found in blueberries, effectively suppressed tumorigenesis and metastasis of cancer stem cells (CSCs) through reduced expressions in promoted(4) and increased tumor cell proliferation of breast cancer(5).

Addition to that, the joint study lead by the Indian Institute of Technology Roorkee showed that pterostilbene not only expressed itself as a effective inducer of apoptosis in human breast in affecting various cellular targets, it also may be a chemopreventive potential based on its stronger anti-proinflammatory cytokines and anti-inflammatory activities against many forms of diseases(6).

In the study of MCF7, Hs578t and MDA-MB-231 breast cancercell lines, pterostilbene suppressed tumor growth and metastasis in MDA-MB-231, the triple-negative breast cancer and Hs578t cells through inhibition of the migratory and invasive potential by blocking the initiate the metastatic process(7).

Further more, the phytochemical also found to inhibit breast cancer regardless of estrogen receptor (ER-α36 positive or negative breast cancer)status by inducing apoptosis(8) and anti-proliferation(9), with or without the execution of cell death in apoptotic cells(8).

The finding of the effectiveness of blueberry and its phytochemical pterostilbene may serve as a cornerstone of pharmaceutical target for further studies as well as a protential medication for treatment of breast disease.

Women who are at high risk of breast cancer such as genetic mutation genes BRCA1 and BRCA2 should drink at least one cup daily and women with breast cancer should drink the juices as much as they can depending to digestive toleration.

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

References
(1) Chemopreventive and therapeutic activity of dietary blueberry against estrogen-mediated breast cancer by Jeyabalan J1, Aqil F, Munagala R, Annamalai L, Vadhanam MV, Gupta RC.(PubMed)
(2) Inhibition of estrogen-mediated mammary tumorigenesis by blueberry and black raspberry by Ravoori S1, Vadhanam MV, Aqil F, Gupta RC.(PubMed)
(3) Berries and ellagic acid prevent estrogen-induced mammary tumorigenesis by modulating enzymes of estrogen metabolism by Aiyer HS1, Gupta RC.(PubMed)
(4) Pterostilbene, a bioactive component of blueberries, suppresses the generation of breast cancer stem cells within tumor microenvironment and metastasis via modulating NF-κB/microRNA 448 circuit by Mak KK1, Wu AT, Lee WH, Chang TC, Chiou JF, Wang LS, Wu CH, Huang CY, Shieh YS, Chao TY, Ho CT, Yen GC, Yeh CT.(PubMed)
(5) Twist modulates breast cancer stem cells by transcriptional regulation of CD24 expression by Vesuna F1, Lisok A, Kimble B, Raman V.(PubMed)
(6) Understanding the mode of action of a pterostilbene derivative as anti-inflammatory agent by Nikhil K1, Sharan S1, Palla SR2, Sondhi SM2, Peddinti RK2, Roy P3.(PubMed)
(7) Pterostilbene inhibits triple-negative breast cancer metastasis via inducing microRNA-205 expression and negatively modulates epithelial-to-mesenchymal transition by Su CM1, Lee WH2, Wu AT3, Lin YK4, Wang LS5, Wu CH6, Yeh CT7.(PubMed)
(8) Estrogen receptor-α36 is involved in pterostilbene-induced apoptosis and anti-proliferation in in vitro and in vivobreast cancer by Pan C1, Hu Y2, Li J3, Wang Z4, Huang J5, Zhang S1, Ding L5.(PubMed)
(9) Estrogen receptor-α36 is involved in pterostilbene-induced apoptosis and anti-proliferation in in vitro and in vivobreast cancer by Pan C1, Hu Y2, Li J3, Wang Z4, Huang J5, Zhang S1, Ding L5.(PubMed)

Most Common Diseases of 50plus: Pulmonary vascular disease(Respiratory disease): Pulmonary edema- The Complications

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Respiratory Disease

Respiratory Disease is defined as medical conditions, affecting the breathing organ and tissues including Inflammatory lung disease, Obstructive lung diseases, Restrictive lung diseases, Respiratory tract infections, trachea, bronchi, bronchioles, alveoli, the nerves and muscles breathing, etc,.

Pulmonary vascular disease: Pulmonary edema

Pulmonary vascular disease is defined as a condition of blood flow to the lung’s artery is blocked suddenly due to a blood clot somewhere in the body, including pulmonary embolism, chronic thromboembolic disease, pulmonary arterial hypertension, pulmonary veno-occlusive disease, pulmonary arteriovenous malformations, pulmonary edema, etc.

Pulmonary edema is defined as a condition of fluid accumulation in the air spaces and parenchyma of the lungs of that can lead to difficult of breathing and respiratory failure.

The Complications

1. Acute heart attack (myocardial infarction [MI])
According to the article by American medical network, typical causes of acute cardiogenic pulmonary edema include acute myocardial infarction or severe ischemia, exacerbation of chronic heart failure, acute volume overload of the left ventricle (valvular regurgitation), and mitral stenosis(11).
2. Cardiogenic shock
According to the study to identify the independent predictors of 30-day mortality and to analyse the outcomes of patients with cardiogenic shock (CS) associated with acute myocardial infarction (AMI) and necessitating extracorporeal life support (ECLS), of a total 77 patients who had required ECLS support for AMI with CS, Pulmonary oedema occurred in 24 patients (31.6%)(12).
3. Arrhythmias
In Thirty cases (23 males) of post cardioversion acute pulmonary edema identified with the mean age was 53.8 +/- 13 years (range, 18 to 75 years), underlying arrhythmias were atrial fibrillation (69%), atrial flutter (24%), supraventricular tachycardia (4%), and ventricular tachycardia (4%). The duration of arrhythmia preceding cardioversion varied widely ranging from 1 day to 13 years, according to Beth Israel Medical Cente(13).
4. Electrolyte disturbances
According to the article of Fluid and Electrolyte Regulation by Kathryn E.Roberts, respiratory system examination includes an assessment of thepatient’s respiratory effort, an increaseor decrease in respiratory rate and depth, and work of breathing.The presence of rales on auscultation, indicating fluid volume excess, is observed(14).
5. Protein enteropathyIn the differential diagnosis, protein-losing enteropathy (PLE) is a rarely considered explanation of edema. Three such cases are reported in this the study by the Kaohsiung Medical University(15).
6. Death.

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

Sources
(a) http://www.ncbi.nlm.nih.gov/pubmed/19739476
(11) http://www.health.am/cardio/more/acute_heart_failure_pulmonary_edema/
(12) http://www.ncbi.nlm.nih.gov/pubmed/23616484
(13) http://www.ncbi.nlm.nih.gov/pubmed/14659864
(14) http://repository.upenn.edu/cgi/viewcontent.cgi?filename=10&article=1003&context=miscellaneous_papers&type=additional
(15) http://www.ncbi.nlm.nih.gov/pubmed/12036201

Friday, April 8, 2016

Most Common Disease of 50Plus: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Osteoarthritis: Medication and Surgical Treatment in Conventional Medicine

Kyle J. Norton (Scholar)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed. A major restriction of joint movement range was frequent in the shoulder but uncommon in other joints(1).

Types of Musculo-Skeletal disorders in elder(2)
1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia

Osteoarthritis

Osteoarthritis (OA), a form of arthritis, is defined as a condition of as a result of aging causes of wear and tear on a joint, affecting over 25 million people in the United States in alone. University of Porto Medical School indicated that one must understand the differences in prevalence and incidence estimates of osteoarthritis (OA), according to case definition, in knee, hip and hand joints(3).
The characteristics of osteoarthritis are aching pain(5), stiffness(6), or difficulty of moving the joint or joints(7). The pain usually gets worse in change of weather, at night and in the advanced diseases, the pain can occur even at rest(8). Today management of osteoarthritis (OA) focuses on pain relief and improved physical function through pharmacological, non pharmacological, and surgical treatments(4).

The Treatment

A. In conventional medicine
2. Medication
Medication or combined medication are used to stop the progression and relieve the symptoms of the diseases may include
2.1. Medication for reduced symptoms
Nonsteroidal anti-inflammatory drugs (NSAIDs)can be bought as over counter medicine for reduced pain and inflammation for patient with rheumatoid arthritis with an incidence of significant upper GI toxic effects, according to a total of 8059 patients (>/=18 years old) with osteoarthritis (OA) or rheumatoid arthritis (RA)(186). Dr. Wienecke T and Dr. Gøtzsche PC. in the comparison of NSAIDs and Paracetamol for treatment of RA said " There is a need for a large trial, with appropriate randomisation, double-blinding, test of the success of the blinding, and with explicit methods to measure and analyse pain and adverse effects"(187) due to favorable of onsteroidal anti-inflammatory drugs (NSAIDs) in general population.

2.2. Medication for interfering the disease progression
a. Corticosteroids
Corticosteroid, a class a class of chemicals including the steroid hormones medication prednisone, prednisolone and methyprednisolone have been used in conventional medicine for quick treatment of inflammatory diseases such as rheumatoid arthritis, through reduced in activity and expression as a result of oxidative/nitrative stress(188). The University de Montréal joint study of 838 patient indicated the effectiveness of corticosteroids for treatment of inflammation of RA may accompany with increased hazard of infection(189), risk for the development of secondary osteoporosis(190) and dyslipidemia and hypertension(192). adrenal suppression, bone loss, skin thinning, increased cataract formation, decreased linear growth in children, metabolic changes, and behavioral abnormalities(191).

b. DMARDs, (Disease-modifying antirheumatic drugs)

DMARDs, a disease-modifying antirheumatic drug such as methotrexate, hydroxycholorquine, sulfasalazine, leflunomide used by conventional doctor to modify the course of the disease(RA in this case) by releasing 4 h later to coincide with the rise of nocturnal inflammatory cytokines associated with development of symptoms of RA(192). According to the report of Dr. Sitzia J and Dr. Huggins L. the adverse effects of DMARDs may include alopecia, fatigue, weight gain with fatigue and nausea to be the "most troublesome" problems, followed by difficulty sleeping and sore eyes(193), as well as other incidences of gastrointestinal side effects(194).

c. Biologics
Biologics including abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, infliximab, golimumab and rituximab works with similar effects as DMARDs but more quickly in blocking a specific step in the inflammation process, such as blocking the activation of T cells(197), B cells(198), pro inflammatory cytokines(199),...... have found significantly improved outcomes for patients with rheumatoid arthritis(195), through reducing the signs and symptoms of RA, slowing radiographic progression of joint destruction, and improving physical function and quality of life in patients with RA(196).

d. JAK inhibitors
JAK inhibitors, the medication used in conventional doctors for inhibition of the activity of one or more of the Janus kinase family of enzymes, involving function in cytokine receptor signalling pathway, through interaction with signal transducers(transmission of molecularsignals from a cell's exterior to its interior) and activators of transcription proteins(a sequence-specific DNA-binding factor in controlling the rate of transcription of genetic information from DNA to messenger RNA)(200) is also known as a new subcategory of DMARDs. Dr. Norman P. said" JAK inhibitors differ in isoform specificity profiles, with good efficacy achievable by selective inhibition of either JAK1 (filgotinib or INCB-039110) or JAK3 (decernotinib)' of that contrite to the effective treatment of patient with rheumatoid arthritis)(201). According to the University of Occupational and Environmental Health, use of Tofacitinib, a new class of DMARDs orally available exhibited a strong clinical efficacy similar to biologic DMARDs through inhibited multiple cytokines and signaling pathways at clinical doses that are in contrast to biological DMARDs(202).

Here, we quoted the criteria of medication or combined medication is used to stop the progression and relieve the symptoms of RA by Dr. da Mota LM, and scientists at the Universidade de Brasília
1) The therapeutic decision should be shared with the patient;
2) Immediately after the diagnosis, a disease-modifying antirheumatic drug (DMARD) should be prescribed, and the treatment adjusted to achieve remission;
3) Treatment should be conducted by a rheumatologist;
4) The initial treatment includes synthetic DMARDs;
5) Methotrexate is the drug of choice;
6) Patients who fail to respond after two schedules of synthetic DMARDsshould be assessed for the use of biologic DMARDs;
7) Exceptionally, biologic DMARDs can be considered earlier;
8) Anti-TNF agents are preferentially recommended as the initial biologic therapy; 9) after therapeutic failure of a first biologic DMARD, other biologics can be used;
10) Cyclophosphamide and azathioprine can be used in severe extra-articular manifestations;
11) Oral corticoid is recommended at low doses and for short periods of time;
12) Non-steroidal anti-inflammatory drugs should always be prescribed in association with a DMARD; 13) clinical assessments should be performed on a monthly basis at the beginning of treatment;
14) Physical therapy, rehabilitation, and occupational therapy are indicated;
15) Surgical treatment is recommended to correct sequelae;
16) Alternative therapy does not replace traditional therapy;
17) Family planning is recommended;
18) The active search and management of comorbidities are recommended;
19) The patient’s vaccination status should be recorded and updated;
20) Endemic-epidemic transmissible diseases should be investigated and treated.

3. Surgery
Surgery in some cases may be necessary to relieve severe pain and extensive joint deformities and with patient do not response to non and medical treatment. According to the Wrightington Hospital NHS Trust, in the study of postoperative infection or surgical complications occurring within one year of surgery in patient with RA found that the surgical procedure induced 27% of infection and complication for patient with different in the intake of Methotrexate(204), a synthetic compound used for treatment of some forms of cancers.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer recommended by Kyle J. Norton

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
References
(1) 8 Areas of Age-Related Change(NIH)
(2) Arthritis-Related Statistics(CDC)
(3) Valgus deformities of the feet and characteristics of gait in patients who have rheumatoid arthritis by Keenan MA1, Peabody TD, Gronley JK, Perry J.(PubMed)
(4) Serum Sclerostin Level Among Egyptian Rheumatoid Arthritis Patients: Relation to Disease Activity ,Bone Mineral Density and Radiological Grading by Mehaney DA, Eissa M, Anwar S, El-Din SF(PubMed)
(4a) Death rates and causes of death in patients with rheumatoid arthritis: a population-based study by Sihvonen S1, Korpela M, Laippala P, Mustonen J, Pasternack A(PubMed)

(185) A randomized double-blind sham-controlled trial of the Prosorba column for treatment of refractory rheumatoid arthritis by Gendreau RM1; Prosorba Clinical Trial Group(PubMed)
(186) Gastrointestinal toxicity with celecoxib vs nonsteroidal anti-inflammatory drugs for osteoarthritis andrheumatoid arthritis: the CLASS study: A randomized controlled trial. Celecoxib Long-term Arthritis Safety Study by Silverstein FE1, Faich G, Goldstein JL, Simon LS, Pincus T, Whelton A, Makuch R, Eisen G, Agrawal NM, Stenson WF, Burr AM, Zhao WW, Kent JD, Lefkowith JB, Verburg KM, Geis GS.(PubMed)
(187) Paracetamol versus nonsteroidal anti-inflammatory drugs for rheumatoid arthritis by Wienecke T1, Gøtzsche PC.(PubMed)
(188) How corticosteroids control inflammation: Quintiles Prize Lecture 2005 by Barnes PJ1.(PubMed)
(189) Use of corticosteroids in patients with rheumatoid arthritis treated with infliximab: treatment implications based on a real-world Canadian population by Haraoui B1, Jovaisas A2, Bensen WG3, Faraawi R3, Kelsall J4, Dixit S3, Rodrigues J5, Sheriff M6, Rampakakis E7, Sampalis JS7, Lehman AJ8, Otawa S8,Nantel F8, Shawi M8.(PubMed)
(190) Adverse effects of corticosteroids on bone metabolism: a review by Mitra R1.(PubMed)
(191) Adverse effects of inhaled corticosteroids by Hanania NA1, Chapman KR, Kesten S.(PubMed)
(191) Adverse effects of corticosteroids on the cardiovascular system by Sholter DE1, Armstrong PW.(PubMed)
(192) Delayed-release prednisone improves fatigue and health-related quality of life: findings from the CAPRA-2 double-blind randomised study in rheumatoid arthritis by Alten R1, Grahn A2, Holt RJ3, Rice P4, Buttgereit F5.(PubMed)
(193) Side effects of cyclophosphamide, methotrexate, and 5-fluorouracil (CMF) chemotherapy for breast cancer by Sitzia J1, Huggins L.(PubMed)
(194) Folic acid and folinic acid for reducing side effects in patients receiving methotrexate for rheumatoid arthritis by Shea B1, Swinden MV2, Ghogomu ET2, Ortiz Z2, Katchamart W2, Rader T2, Bombardier C2, Wells GA2, Tugwell P2.(PubMed)
(195) Biologics in rheumatoid arthritis: where are we going? by Fechtenbaum M1, Nam JL, Emery P.(PubMed)
(196) Use of biologics in rheumatoid arthritis: where are we going? by Pucino F Jr1, Harbus PT, Goldbach-Mansky R.(PubMed)
(197) [Efficacy and safety of abatacept in patients with rheumatoid arthritis and no prior treatment with biologics].[Article in Spanish] by Escudero Contreras A1, Castro-Villegas MC, Hernández-Hernández MV, Díaz-González F.(PubMed)
(198) Complement activation and C3b deposition on rituximab-opsonized cells substantially blocks binding of phycoerythrin-labeled anti-mouse IgG probes to rituximab by Beum PV1, Kennedy AD, Li Y, Pawluczkowycz AW, Williams ME, Taylor RP.(PubMed)
(199) Infections and biological therapy in rheumatoid arthritis by Cunnane G1, Doran M, Bresnihan B.(PubMed)
(200) Transcription factors: An overview by David S. Latchman(Science direct)
(201) Selective JAK inhibitors in development for rheumatoid arthritis by Norman P1.(PubMed)
(202) Targeting the Janus kinases in rheumatoid arthritis: focus on tofacitinib by Yamaoka K1, Tanaka Y.(PubMed)
(203) Methotrexate and early postoperative complications in patients with rheumatoid arthritis undergoing elective orthopaedic surgery by Grennan DM1, Gray J, Loudon J, Fear S.(PubMed)

(204) 2012 Brazilian Society of Rheumatology Consensus for the treatment of rheumatoid arthritis.[Article in English, Portuguese] by da Mota LM1, Cruz BA, Brenol CV, Pereira IA, Rezende-Fronza LS, Bertolo MB, de Freitas MV, da Silva NA, Louzada-Júnior P, Giorgi RD, Lima RA, da Rocha Castelar Pinheiro G; Brazilian Society of Rheumatology.(PubMed)

The Best Smoothie of Carrot and Sweet Potato for Prevention and Treatment of Breast Fat Necrosis(oil cysts)

1 cup rice milk

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately

Fat necrosis (oil cysts) are conditions of benign breast lesion caused by damage of fatty breast tissue due to injure. According to the University of Tokyo School of Medicine, Oil cysts are the worst outcome of fat grafting, as it may lead to long-term chronic inflammation persistence and calcification in progress without limits(1).

The finding of a natural source for reduced risk and treatment of fat necrosis and oil cysts to replace the conventional medicine has been running into many obstacles, many ingredients showed initially with promising result in animal studies have not produced same potentials in large sample size and mutli centers human trials.

Recent studies from well known institutions suggested that vitamin E(Sweet potato) may process naturally potential ingredients, for reduced risk and treatment for Fat necrosis (oil cysts). According to the Malaysian Palm Oil Board, 6 Persiaran Insitusi, higher adipose tissue concentrations of (vitamin E)tocotrienols in benign patients may provide protection against breast cancer(2).
Dr. Sylvester P and Dr., Shah SJ said,"dietary supplementation of tocotrienols may provide significant health benefits in lowering the risk of breast cancer in women"......through" antiproliferative and cytotoxic effects"(3).

Vitamin A, found abundantly in carrot also expressed protective effect of breast adipose tissue through its derivatives 9-cis beta-carotene and zeta-carotene from lactating women and serum and breast adipose tissue samples(4). According to the Tufts University, concentrations of the major serum carotenoids are correlated to breast adipose tissue carotenoid levels, as a substantial amount of 9-cis beta-carotenewas presented in adipose tissue had a significantly lower level in benign breast tumor patients(5).

The effectiveness of Carrot and Sweet Potato may serve as cornerstones of pharmaceutical target for further studies in production of a potential medication for for Reduced Risk and treatment of Breast Fat Necrosis (oil cysts) with little or no adverse effects.

Women who are at increased risk of Breast Fat Necrosis (oil cysts) may drink at least one serving daily and women with Breast Fat Necrosis (oil cysts) may drink as much as they can, depending to the digestive toleration.
Life style and dietary patter change are recommended.

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

References

(1) Chronic inflammation and progressive calcification as a result of fat necrosis: the worst outcome in fat grafting by Mineda K1, Kuno S, Kato H, Kinoshita K, Doi K, Hashimoto I, Nakanishi H, Yoshimura K.(PubMed)
(2) Tocotrienol levels in adipose tissue of benign and malignant breast lumps in patients in Malaysia by Nesaretnam K1, Gomez PA, Selvaduray KR, Razak GA.(PubMed)
(3) Mechanisms mediating the antiproliferative and apoptotic effects of vitamin E in mammary cancer cells by Sylvester PW1, Shah SJ.(PubMed)
(4) Determination of 9-cis beta-carotene and zeta-carotene in biological samples by Qin J1, Yeum KJ, Johnson EJ, Krinsky NI, Russell RM, Tang G.(PubMed)
(5) Correlation between carotenoid concentrations in serum and normal breast adipose tissue of women with benignbreast tumor or breast cancer by Yeum KJ1, Ahn SH, Rupp de Paiva SA, Lee-Kim YC, Krinsky NI, Russell RM.(PubMed)

Most Common Diseases of 50plus: Pulmonary vascular disease(Respiratory disease): Pulmonary edema- The Risk Factors

Pulmonary edema is defined as a condition of fluid accumulation in the air spaces and parenchyma of the lungs of that can lead to difficult of breathing and respiratory failure.

The Risk factors

1. High altitude
High altitude pulmonary edema (HAPE) is a noncardiogenic pulmonary edema which typically occurs in lowlanders who ascend rapidly to altitudes greater than 2500-3000 m with early symptoms of HAPE include a nonproductive cough, dyspnoea on exertion and reduced exercise performance(8).
2. Swimming induced pulmonary edema (SIPE)
SIPE can be described as a cardiogenic pulmonary edema, at least in part, since an increased transalveolar pressure gradient has been implicated in the pathogenesis of SIPE. Brain natriuretic peptide (BNP) is used in the clinical setting to differentiate cardiac from pulmonary sources of dyspnea, specifically to diagnose cardiogenic pulmonary edema, according to the study by the Loyola University Medical Center(9).
3. Chronic kidney disease
According to the study by the The VA Medical Center, Chronic kidney disease is often associated with predisposing cardiac risk factors that make patients susceptible to development of flash pulmonary edema(10).
4. Prior history of pulmonary edema
Patients with Prior history of pulmonary edema are at increased risk of recurrent pulmonary edema.
5. Hypertension
Many patients with flash pulmonary edema have preserved systolic left ventricular function and coronary artery disease. Flash pulmonary edema frequently reoccurs in association with marked systolic hypertension, even after coronary revascularization. This suggests that control of hypertension is important and that coronary revascularization may not be adequate to prevent reoccurrence of flash pulmonary edema(10a).
6. History of lung diseases
There is a report of a case of NPE in a middle-aged female patient following a breakthrough seizure in whom an immunological cause for respiratory findings was high on the differential list, based on her past medical history and chronicity of symptoms. Rapid symptomatic and radiological improvement following hospitalization led to the correct diagnosis(10b).
7. Increased vascular permeability
Increased vascular permeability contributes to many diseases, including acute respiratory distress syndrome, cancer and inflammation. studies reveal that pulmonary vascular leakage can be increased by altering extracellular matrix compliance in vitro and by manipulating lysyl oxidase-mediated collagen crosslinking in vivo. Either decreasing or increasing extracellular matrix stiffness relative to normal levels disrupts junctional integrity and increases vascular leakage. The identification of lysyl oxidase and the extracellular matrix as critical regulators of lung vascular leakage might lead to the development of new therapeutic approaches for the treatment of pulmonary oedema and other diseases caused by abnormal vascular permeability, according to the Children’s Hospital and Harvard Medical School, Boston(10c).
8. Etc.

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

Sources
(a) http://www.ncbi.nlm.nih.gov/pubmed/19739476
(8) http://www.ncbi.nlm.nih.gov/pubmed/23580834
(9) http://www.ncbi.nlm.nih.gov/pubmed/19739476
(10) http://www.ncbi.nlm.nih.gov/pubmed/17345689
(10a) http://www.ncbi.nlm.nih.gov/pubmed/10966547
(1b) http://www.ncbi.nlm.nih.gov/pubmed/22919397
(10c) http://www.ncbi.nlm.nih.gov/pubmed/23612300

Thursday, April 7, 2016

Most Common Disease of 50Plus: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Osteoarthritis: Non Medication Treatment in Conventional Medicine

Kyle J. Norton (Scholar)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed. A major restriction of joint movement range was frequent in the shoulder but uncommon in other joints(1).

Types of Musculo-Skeletal disorders in elder(2)
1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia

Osteoarthritis

Osteoarthritis (OA), a form of arthritis, is defined as a condition of as a result of aging causes of wear and tear on a joint, affecting over 25 million people in the United States in alone. University of Porto Medical School indicated that one must understand the differences in prevalence and incidence estimates of osteoarthritis (OA), according to case definition, in knee, hip and hand joints(3).
The characteristics of osteoarthritis are aching pain(5), stiffness(6), or difficulty of moving the joint or joints(7). The pain usually gets worse in change of weather, at night and in the advanced diseases, the pain can occur even at rest(8). Today management of osteoarthritis (OA) focuses on pain relief and improved physical function through pharmacological, non pharmacological, and surgical treatments(4).

The Treatment

A. In conventional medicine perspective
The aim of treatment is to stop the progression and relieve the symptoms of the diseases
1. Non Medication
1.1. Physical therapy
Physical therapy with functions of re mediated impairments and promoted mobility, used conjunction with others including education, medical treatment,and occupational therapy may play an essential role for management of RA(172). In the treatment of patient with RA using the Whole-body cryotherapy (WBC) in supplement to physical therapy, Dr. combination and the research team at the joint study lead by the University School of Physical Education in Poznań said" (The combined therapies showed )improvement in pain, disease activity, fatigue, time of walking, and the number of steps over a distance of 50 m,...... similar significant reduction in IL-6 and TNF-α level (the inflammatory cytokines),...regardless of the kind of the applied physical procedure in patient with RA(173).

1.2. Relaxation therapy and biofeedback training
Relaxation and temperature biofeedback training as an adjunctive therapy has showed to alleviate both pain and stress-related symptoms as well as improvement of pain, tension, and sleep patterns. In fact, the therapy are found to induced higher physical/functional indices in comparison to physical therapy(174). Dr. Astin JA. and the research team at the University of Maryland School of Medicine suggested that psychological interventions such as relaxation, biofeedback, cognitive-behavioral therapy, may form an important part in may be important adjunctive therapies in the medical management of RA, especially for patients who have had the illness for shorter duration(175).In fact, a systematic review and meta-analysis of randomized controlled trials, also showed that psychological intervention improved both depressive symptoms and anxiety among patients with RA(176).

1.3. Low level laser therapy
Low level laser therapy may be beneficiary in modulated inflammatory response both in early as well as in late progression stages of RA, through its effects in significantly improved mononuclear inflammatory cells(177) as well as modulating inflammatory mediators (IL-1β, IL-6)(178). The study of 132 patients at the age varying from 18 to 85 years presenting with rheumatoid arthritis by Dr.Kulova LA, and Dr. Burduli NM also found thatn the therapy showed an improvement of the endothelial function and the microcirculation indices in patient with rheumatoid arthritis(179). But according to a randomized double-blind controlled trial laser therapy using low-level aluminum gallium arsenide was not effective at the wavelength, dosage, and power studied for the treatment of hands among patients with rheumatoid arthritis(180).

1.4. Occupational therapy
According to the Canadian association of occupation therapy, it is form of treatment to solve the problems that interfere with your ability to do the things that are important to you. It can also prevent a problem or minimize its effects(181). According to the Netherlands Institute for Health Services Research, in controlled (randomized and non-randomized) and other than controlled studies (OD) addressing OT for RA patients showed that occupation therapy improved outcome on functional ability, social participation and/or health related quality of life(182). Rheumatologically, occupation therapy in many cases has successfully improved and maintained functional capacity, prevented progression of deformities, ......... of that may require for the engagement of the individual in meaningful occupations, favoring autonomy and independence in self-care activities, employment, educational, social and leisure(183)
1.5. Prosorba column apheresis therapy (PCT)
Prosorba column apheresis therapy (PCT), a medical device containnig purified staphylococcal protein A covalently bound to a silica matrix has been used in many medical centers for treatment severerheumatoid arthritis (RA) since its approval in 1999(184) with some promising result(185).
The therapy showed a 52% improvement in joint tenderness, 40% improvement in swelling, 42% improvement in patient's pain, 38% improvement in patient's global response, and 48% improvement in physician's global scores 76% of responders, according to the study by Cypress Bioscience(184).

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer recommended by Kyle J. Norton

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
References
(1) 8 Areas of Age-Related Change(NIH)
(2) Arthritis-Related Statistics(CDC)
(3) Valgus deformities of the feet and characteristics of gait in patients who have rheumatoid arthritis by Keenan MA1, Peabody TD, Gronley JK, Perry J.(PubMed)
(4) Serum Sclerostin Level Among Egyptian Rheumatoid Arthritis Patients: Relation to Disease Activity ,Bone Mineral Density and Radiological Grading by Mehaney DA, Eissa M, Anwar S, El-Din SF(PubMed)
(4a) Death rates and causes of death in patients with rheumatoid arthritis: a population-based study by Sihvonen S1, Korpela M, Laippala P, Mustonen J, Pasternack A(PubMed)

(172) Juvenile rheumatoid arthritis: physical therapy and rehabilitation by Cakmak A1, Bolukbas N.(PubMed)
(173) Effects of Whole-Body Cryotherapy in Comparison with Other Physical Modalities Used with Kinesitherapy inRheumatoid Arthritis by Gizińska M1, Rutkowski R1, Romanowski W2, Lewandowski J3, Straburzyńska-Lupa A4.(PubMed)
(174) Rheumatoid arthritis: a study of relaxation and temperature biofeedback training as an adjunctive therapy by Achterberg J, McGraw P, Lawlis GF.(PubMed)
(175) Psychological interventions for rheumatoid arthritis: a meta-analysis of randomized controlled trials by Astin JA1, Beckner W, Soeken K, Hochberg MC, Berman B.(PubMed)
(176) Psychological interventions for rheumatoid arthritis: examining the role of self-regulation with a systematic review and meta-analysis of randomized controlled trials by Knittle K1, Maes S, de Gucht V.(PubMed)
(177) Low-level laser therapy in different stages of rheumatoid arthritis: a histological study by Alves AC1, de Carvalho PT, Parente M, Xavier M, Frigo L, Aimbire F, Leal Junior EC, Albertini R.(PubMed)
(178) Effect of low-level laser therapy on the expression of inflammatory mediators and on neutrophils and macrophages in acute joint inflammation by Alves AC, Vieira R, Leal-Junior E, dos Santos S, Ligeiro AP, Albertini R, Junior J, de Carvalho P.(PubMed)
(179) [The influence of intravenous laser therapy on the endothelial function and the state of microcirculation in the patients presenting with rheumatoid arthritis].[Article in Russian] by Kulova LA, Burduli NM.(PubMed)
(180) Assessment of the effectiveness of low-level laser therapy on the hands of patients with rheumatoid arthritis: a randomized double-blind controlled trial by Meireles SM1, Jones A, Jennings F, Suda AL, Parizotto NA, Natour J.(PubMed)
(181) What is occupation therapy(Canadian association of occupation therapy)
(182) Occupational therapy for rheumatoid arthritis by Steultjens EM1, Dekker J, Bouter LM, van Schaardenburg D, van Kuyk MA, van den Ende CH.(PubMed)
(183) [Occupational therapy in rheumatoid arthritis: what rheumatologists need to know?].[Article in Portuguese] by de Almeida PH1, Pontes TB2, Matheus JP2, Muniz LF3, da Mota LM3.(PubMed)
(184) Effects of Prosorba column apheresis in patients with chronic refractory rheumatoid arthritis by
Roth S1(PubMed)