Kyle J. Norton (Scholar)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Musculoskeletal disorders (MSDs) are medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed. A major restriction of joint movement range was frequent in the shoulder but uncommon in other joints(1).
Types of Musculo-Skeletal disorders in elder(2)
1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia
Osteoarthritis
Osteoarthritis (OA), a form of arthritis, is defined as a condition of as a result of aging causes of wear and tear on a joint, affecting over 25 million people in the United States in alone. University of Porto Medical School indicated that one must understand the differences in prevalence and incidence estimates of osteoarthritis (OA), according to case definition, in knee, hip and hand joints(3).
The characteristics of osteoarthritis are aching pain(5), stiffness(6), or difficulty of moving the joint or joints(7). The pain usually gets worse in change of weather, at night and in the advanced diseases, the pain can occur even at rest(8). Today management of osteoarthritis (OA) focuses on pain relief and improved physical function through pharmacological, non pharmacological, and surgical treatments(4).
B. In herbal and traditional Chinese medicine perspective
B.2. Psychological intervention
Psychological intervention may be useful to reduce depression, anxiety and other symptoms in patient with RA due to associate to pain, distress and disability and reduced quality of life style in chronic pain patients, the University College London suggested(223). Dr. Matcham F and the research team at the joint study lead by King's College London said" The most consistent relationship was found between mood and fatigue, with low mood frequently associated with increased fatigue. Some evidence also highlighted the relationship between RA-related cognitions (such as RA self-efficacy) and fatigue, and non-RA-cognitions (such as goal ownership) and fatigue(224), as there is a psychological correlates of fatigue in rheumatoid arthritis.
Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offerrecommended by Kyle J. Norton
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
References
(223) Psychological therapies for the management of chronic pain (excluding headache) in adults by Williams AC1, Eccleston C, Morley S.(PubMed)
(224) Psychological correlates of fatigue in rheumatoid arthritis: a systematic review by Matcham F1, Ali S2, Hotopf M3, Chalder T4.(PubMed)
Sunday, April 10, 2016
The Smoothie of Vitamin D fortified whole milk, Alpha Lipoic acid (LA) and Orange Juice for Prevention and Treatment of podocyte injury Focal segmental glomerulosclerosis
Kyle J. Norton(Scholar, Master of Nutrient, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Focal segmental glomerulosclerosis is scar tissues in the filtering unit of the kidney due to primary glomerular diseases in children and adolescents inducing edema and the loss of protein from the plasma into the urine. The syndrome may result of kidney failure when affected children and adolescents grow into adulthood. According to Dr. Fogo AB, Focal segmental glomerulosclerosis (FSGS) has a common lesion in progressive kidney disease, and a disease characterized by marked proteinuria and podocyte injury(*).
Recent studies back by well known institutions proposed, Vitamin D fortified whole milk, Lipoic acid (LA) and Orange Juice may be the next generation of natural ingredients for prevention and treatment of podocyte injury due to Focal segmental glomerulosclerosis.
According to the Tokai University School of Medicine, the primary insult of podocyte injury may be short-lived. but the transmission of podocyte injury may form a vicious cycle leading to accelerated pother odocyte deterioration and glomerulosclerosis(1). Vitamin D is a fat-soluble secosteroids found in small amount in few foods, including mushroom may benefit patients of focal segmental glomerulosclerosis caused by podocyte injury(2). According to the Southeast University School of Medicine, vitamin D ameliorated podocyte injury in STZ-induced diabetic rats through down regulated over expression of TRPC6 involved the developed focal segmental glomerulosclerosis (FSGS)(3).
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Focal segmental glomerulosclerosis is scar tissues in the filtering unit of the kidney due to primary glomerular diseases in children and adolescents inducing edema and the loss of protein from the plasma into the urine. The syndrome may result of kidney failure when affected children and adolescents grow into adulthood. According to Dr. Fogo AB, Focal segmental glomerulosclerosis (FSGS) has a common lesion in progressive kidney disease, and a disease characterized by marked proteinuria and podocyte injury(*).
The smoothie for prevention and treatment of podocyte injury
Yield: 2 servings (about 8 ounces each)
1 cup Vitamin D fortified whole milk
20 mg Alpha Lipoic acid (LA)
1 cup organic orange juice
1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately
The finding of a natural source for treatment of podocyte injury has been running into many obstacles, many ingredients showed initially with promising result in animal studies have not produced same potentials in large sample size and mutli centers human trials.
Recent studies back by well known institutions proposed, Vitamin D fortified whole milk, Lipoic acid (LA) and Orange Juice may be the next generation of natural ingredients for prevention and treatment of podocyte injury due to Focal segmental glomerulosclerosis.
According to the Tokai University School of Medicine, the primary insult of podocyte injury may be short-lived. but the transmission of podocyte injury may form a vicious cycle leading to accelerated pother odocyte deterioration and glomerulosclerosis(1). Vitamin D is a fat-soluble secosteroids found in small amount in few foods, including mushroom may benefit patients of focal segmental glomerulosclerosis caused by podocyte injury(2). According to the Southeast University School of Medicine, vitamin D ameliorated podocyte injury in STZ-induced diabetic rats through down regulated over expression of TRPC6 involved the developed focal segmental glomerulosclerosis (FSGS)(3).
Lipoic acid (LA), a naturally occurring dithiol compound, has long been known as an essential cofactor for mitochondrial bioenergetic enzymes may also benefits to protect against podocyte injury. According to Anhui Provincial Hospital Affiliated to Anhui Medical University," Anti-inflammation of ALA in vivo and local kidney is implicated in the protection of glomerular Pod injury in patients with type 2 diabetes"(4).
Dr. Lin H and colleagues in the investigation of anti-inflammation of alpha-lipoic acid in type 2 diabetics, suggested that ALA exhibited protection against glomerular podocyte injury in type 2 diabetics through alleviating enhanced OS and strengthening antioxidant ability in vivo(5).
Ascorbic acid also known as vitamin C found abundantly in orange may also exhibit renal podocytes protection effects by increasing antioxidative capacity and ameliorating the renal oxidative stress(6).
Dr. Lin H and colleagues in the investigation of anti-inflammation of alpha-lipoic acid in type 2 diabetics, suggested that ALA exhibited protection against glomerular podocyte injury in type 2 diabetics through alleviating enhanced OS and strengthening antioxidant ability in vivo(5).
Ascorbic acid also known as vitamin C found abundantly in orange may also exhibit renal podocytes protection effects by increasing antioxidative capacity and ameliorating the renal oxidative stress(6).
According to L. Rydygier Medical University of Bydgoszcz, vitamin C expressed potential utility of antioxidant vitamins in the protection against the development of diabetic nephropathy (7) induced podocyte injury.
The effectiveness of Vitamin D fortified whole milk, Alpha Lipoic acid (LA) and Orange Juice may serve as cornerstones of pharmaceutical target for further studies in production of a potential medication for reduced risk, complications and treatment of podocyte injurywith little or no adverse effects.
People who are at high risk of podocyte injury in Focal segmental glomerulosclerosisdue should drink no more than 4 servings daily, depending to digestive toleration.
All Forms of Arthritis are Curable
Ovarian Cysts And PCOS Elimination
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
References
(1) Podocyte injury damages other podocytes by Matsusaka T1, Sandgren E, Shintani A, Kon V, Pastan I, Fogo AB, Ichikawa I.(PubMed)
(2) The novel role of TRPC6 in vitamin D ameliorating podocyte injury in STZ-induced diabetic rats by Zhang X1, Song Z, Guo Y, Zhou M.(PubMed)
(3) REPORT A Mutation in the TRPC6 Cation Channel Causes Familial Focal Segmental Glomerulosclerosis by Michelle P. Winn1,2,*, Peter J. Conlon4, Kelvin L. Lynn5, Merry Kay Farrington1,2, Tony Creazzo3, April F. Hawkins1, Nikki Daskalakis1,2, Shu Ying Kwan2, Seth Ebersviller2, James L. Burchette5, Margaret A. Pericak-Vance1,2, David N. Howell5, Jeffery M. Vance1,2,*, Paul B. Rosenberg1(Science,AAA)
(4) Alleviation of podocyte injury: the possible pathway implicated in anti-inflammation of alpha-lipoic acid in type 2 diabetics by Bao XH1, Xu J, Chen Y, Yang CL, Ye SD.(PubMed)
(5) The alpha-lipoic acid decreases urinary podocalyxin excretion in type 2 diabetics by inhibiting oxidative stress in vivo by Lin H1, Ye S2, Xu J3, Wang W3.(PubMed)
(6) [Study on the effect and mechanism of ascorbic acid on renal podocytes in diabetes].[Article in Chinese] by Qin QJ1, Deng HC, Zhao TF, Cao WF, Liu DF, Lan LZ.(PubMed)
(7) Effect of vitamin E and vitamin C supplementation on antioxidative state and renal glomerular basement membrane thickness in diabetic kidney by Kedziora-Kornatowska K1, Szram S, Kornatowski T, Szadujkis-Szadurski L, Kedziora J, Bartosz G.(PubMed)
(5) The alpha-lipoic acid decreases urinary podocalyxin excretion in type 2 diabetics by inhibiting oxidative stress in vivo by Lin H1, Ye S2, Xu J3, Wang W3.(PubMed)
(6) [Study on the effect and mechanism of ascorbic acid on renal podocytes in diabetes].[Article in Chinese] by Qin QJ1, Deng HC, Zhao TF, Cao WF, Liu DF, Lan LZ.(PubMed)
(7) Effect of vitamin E and vitamin C supplementation on antioxidative state and renal glomerular basement membrane thickness in diabetic kidney by Kedziora-Kornatowska K1, Szram S, Kornatowski T, Szadujkis-Szadurski L, Kedziora J, Bartosz G.(PubMed)
Most Common Diseases of 50plus: Pulmonary vascular disease(Respiratory disease): Pulmonary edema- The Diseases associated to
Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Respiratory Disease
Respiratory Disease is defined as medical conditions, affecting the breathing organ and tissues including Inflammatory lung disease, Obstructive lung diseases, Restrictive lung diseases, Respiratory tract infections, trachea, bronchi, bronchioles, alveoli, the nerves and muscles breathing, etc,.
Pulmonary vascular disease: Pulmonary edema
Pulmonary vascular disease is defined as a condition of blood flow to the lung’s artery is blocked suddenly due to a blood clot somewhere in the body, including pulmonary embolism, chronic thromboembolic disease, pulmonary arterial hypertension, pulmonary veno-occlusive disease, pulmonary arteriovenous malformations, pulmonary edema, etc.
1. Multiple sclerosis
young woman with multiple sclerosis presented to the Emergency Department in acute respiratory failure. She was cyanotic centrally, hypertensive, and tachycardic. The chest X-ray study suggested pulmonary edema, according to the study by the Centre for Neuroscience and Neurological Research, St Vincent’s Hospital(16).
2. Primary cardiac chondroma
Primary chondroma is an exceptionally rare cardiac tumor. There is a report of a case of a patient presenting with acute pulmonary edema with the incidental echocardiographic finding of a large left atrial tumor that was histopathologically diagnosed as primary cardiac chondroma(17).
3. Atrial myxoma
Atrial myxoma is the most common primary cardiac tumor. Its clinical presentation spreads from asymptomatic incidental mass to serious life-threatening cardiovascular complications. There is a report of the case of a 44-year-old man with evening fever and worsening dyspnea in the last weeks, admitted to our hospital for acute pulmonary edema(18).
4. Pleural effusion or pneumothorax
Re-expansion pulmonary edema (RPE) is a rare but potentially fatal complication that can occur following rapid lung expansion while managing patients with pleural effusion or pneumothorax. In this case, fatal outcome occurred due to RPE in a previously healthy young adult male patient subsequent to tube thoracostomy for spontaneous pneumothorax(19),
5. Etc.
All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Sources
(a) http://www.ncbi.nlm.nih.gov/pubmed/19739476
(16) http://www.ncbi.nlm.nih.gov/pubmed/22989694
(17) http://www.ncbi.nlm.nih.gov/pubmed/20889354
(18) http://www.ncbi.nlm.nih.gov/pubmed/23762077
(19) http://www.ncbi.nlm.nih.gov/pubmed/23744860
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Respiratory Disease
Respiratory Disease is defined as medical conditions, affecting the breathing organ and tissues including Inflammatory lung disease, Obstructive lung diseases, Restrictive lung diseases, Respiratory tract infections, trachea, bronchi, bronchioles, alveoli, the nerves and muscles breathing, etc,.
Pulmonary vascular disease: Pulmonary edema
Pulmonary vascular disease is defined as a condition of blood flow to the lung’s artery is blocked suddenly due to a blood clot somewhere in the body, including pulmonary embolism, chronic thromboembolic disease, pulmonary arterial hypertension, pulmonary veno-occlusive disease, pulmonary arteriovenous malformations, pulmonary edema, etc.
Pulmonary edema is defined as a condition of fluid accumulation in the air spaces and parenchyma of the lungs of that can lead to difficult of breathing and respiratory failure.
The Diseases associated to Pulmonary edema
1. Multiple sclerosis
young woman with multiple sclerosis presented to the Emergency Department in acute respiratory failure. She was cyanotic centrally, hypertensive, and tachycardic. The chest X-ray study suggested pulmonary edema, according to the study by the Centre for Neuroscience and Neurological Research, St Vincent’s Hospital(16).
2. Primary cardiac chondroma
Primary chondroma is an exceptionally rare cardiac tumor. There is a report of a case of a patient presenting with acute pulmonary edema with the incidental echocardiographic finding of a large left atrial tumor that was histopathologically diagnosed as primary cardiac chondroma(17).
3. Atrial myxoma
Atrial myxoma is the most common primary cardiac tumor. Its clinical presentation spreads from asymptomatic incidental mass to serious life-threatening cardiovascular complications. There is a report of the case of a 44-year-old man with evening fever and worsening dyspnea in the last weeks, admitted to our hospital for acute pulmonary edema(18).
4. Pleural effusion or pneumothorax
Re-expansion pulmonary edema (RPE) is a rare but potentially fatal complication that can occur following rapid lung expansion while managing patients with pleural effusion or pneumothorax. In this case, fatal outcome occurred due to RPE in a previously healthy young adult male patient subsequent to tube thoracostomy for spontaneous pneumothorax(19),
5. Etc.
All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Sources
(a) http://www.ncbi.nlm.nih.gov/pubmed/19739476
(16) http://www.ncbi.nlm.nih.gov/pubmed/22989694
(17) http://www.ncbi.nlm.nih.gov/pubmed/20889354
(18) http://www.ncbi.nlm.nih.gov/pubmed/23762077
(19) http://www.ncbi.nlm.nih.gov/pubmed/23744860
Saturday, April 9, 2016
Most Common Disease of 50plus: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Osteoarthritis: Life style Modification in alternative medicine
Kyle J. Norton (Scholar)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Musculoskeletal disorders (MSDs) are medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed. A major restriction of joint movement range was frequent in the shoulder but uncommon in other joints(1).
Types of Musculo-Skeletal disorders in elder(2)
1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia
Osteoarthritis
Osteoarthritis (OA), a form of arthritis, is defined as a condition of as a result of aging causes of wear and tear on a joint, affecting over 25 million people in the United States in alone. University of Porto Medical School indicated that one must understand the differences in prevalence and incidence estimates of osteoarthritis (OA), according to case definition, in knee, hip and hand joints(3).
The characteristics of osteoarthritis are aching pain(5), stiffness(6), or difficulty of moving the joint or joints(7). The pain usually gets worse in change of weather, at night and in the advanced diseases, the pain can occur even at rest(8). Today management of osteoarthritis (OA) focuses on pain relief and improved physical function through pharmacological, non pharmacological, and surgical treatments(4).
B. In herbal and traditional Chinese medicine perspective
B.1. Life style modification according herbal and TCM medicine specialist
Life style modification has shown to be beneficiary for patients with osteoartritis to improve musculoskeletal and bone health and reduce disability,according to the University of Tasmania(276). Modern herbal and TCM medicine specialists may suggest the following
1. Lose some weight
Over weight and obesity are found to associate the risk factors and risks of rapid progression of the disease(277)(278). In the discussion of obesity versus osteoarthritis, Dr. Sartori-Cintra AR and the research team at Universidade Estadual de Campinas, indicated that obesity is associated to wide range of diseases, such as osteometabolic diseases, including osteoporosis and osteoarthritis and suggested that physical activity combined with changes in diet composition can reverse the inflammatory and leptin resistance, reducing progression or preventing the onset of osteoarthritis(236).
2. Exercise
Exercise, today is less popular leisure-time activity in many countries throughout the Western world, especially in the youth due to promotion of information collection through mobile phone. According to study, moderate exercise, reduced the risk on the onset and progression of osteoarthritis joint disease(279). According to Boston University Arthritis, habitual physical activity post no risk of knee OA for men or women, during the 18th biennial examination (1983-85), in the study of 1,415 subjects had a mean age of 73 years(279). Walking is found to be the most preference of aerobic exercise tested in the older with knee osteoarthritis, depending to the distance, walking distance improves 26%, 31%, and 15% of pain and physical function, according to Dr.Stephen P. Messier,
Ph.D(280).
Combination of weight loss and exercise in older adults with knee osteoarthritis showed to improve level of leptin of which related to the biomarkers for earlier diagnosis in patient with OA(281).
Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer recommended by Kyle J. Norton
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
References
(1) Prevalence of rheumatic symptoms, rheumatoid arthritis, ankylosing spondylitis, and gout in Shanghai, China: a COPCORD study by Dai SM1, Han XH, Zhao DB, Shi YQ, Liu Y, Meng JM.(PubMed)
(2) Musculoskeletal Disorders in the Elderly by Ramon Gheno, Juan M. Cepparo, Cristina E. Rosca,1 and Anne Cotten(PMC)
(3) The effect of osteoarthritis definition on prevalence and incidence estimates: a systematic review by Pereira D1, Peleteiro B, Araújo J, Branco J, Santos RA, Ramos E.(PubMed)
(4) Effect of therapeutic aquatic exercise on symptoms and function associated with lower limb osteoarthritis: systematic review with meta-analysis by Waller B1, Ogonowska-Slodownik A2, Vitor M3, Lambeck J4, Daly D5, Kujala UM6, Heinonen A7.(PubMed)
(5) Effects of therapeutic ultrasound on pain, physical functions and safety outcomes in patients with kneeosteoarthritis: A systematic review and meta-analysis by Zhang C1, Xie Y2, Luo X3, Ji Q3, Lu C3, He C4, Wang P3.(PubMed)
(6) Oral intake of purple passion fruit peel extract reduces pain and stiffness and improves physical function in adult patients with knee osteoarthritis by Farid R1, Rezaieyazdi Z, Mirfeizi Z, Hatef MR, Mirheidari M, Mansouri H, Esmaelli H, Bentley G, Lu Y, Foo Y, Watson RR.(PubMed)
(7) Functional ability, mobility, and pain before and after knee replacement in patients aged 75 and older: a cross-sectional study by Limnell K1, Jämsen E, Huhtala H, Jäntti P, Puolakka T, Jylhä M.(PubMed)
(8) The symptoms of OA and the genesis of pain by David J. Hunter, MBBS PhD,1,2 Jason J. McDougall, BSc PhD,3 and Francis J. Keefe4(PubMed)
(276) Lifestyle modifications to improve musculoskeletal and bone health and reduce disability--a life-course approach by Jones G1, Winzenberg TM2, Callisaya ML3, Laslett LL4.(PubMed)
(277) Weight loss reduces knee-joint loads in overweight and obese older adults with knee osteoarthritis by Messier SP1, Gutekunst DJ, Davis C, DeVita P.(PubMed)
(278) Effect of weight reduction in obese patients diagnosed with knee osteoarthritis: a systematic review and meta-analysis by Christensen R1, Bartels EM, Astrup A, Bliddal H.(PubMed)
(279) Exercise and osteoarthritis by David J Hunter1,2 and Felix Eckstein3,4(PMC)
(280) Diet and Exercise for Obese Adults with Knee Osteoarthritis by Stephen P. Messier, Ph.D(PMC)
(281)Adipokines: Biomarkers for osteoarthritis? by Thitiya Poonpet and Sittisak Honsawek(PMC)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Musculoskeletal disorders (MSDs) are medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed. A major restriction of joint movement range was frequent in the shoulder but uncommon in other joints(1).
Types of Musculo-Skeletal disorders in elder(2)
1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia
Osteoarthritis
Osteoarthritis (OA), a form of arthritis, is defined as a condition of as a result of aging causes of wear and tear on a joint, affecting over 25 million people in the United States in alone. University of Porto Medical School indicated that one must understand the differences in prevalence and incidence estimates of osteoarthritis (OA), according to case definition, in knee, hip and hand joints(3).
The characteristics of osteoarthritis are aching pain(5), stiffness(6), or difficulty of moving the joint or joints(7). The pain usually gets worse in change of weather, at night and in the advanced diseases, the pain can occur even at rest(8). Today management of osteoarthritis (OA) focuses on pain relief and improved physical function through pharmacological, non pharmacological, and surgical treatments(4).
B. In herbal and traditional Chinese medicine perspective
B.1. Life style modification according herbal and TCM medicine specialist
Life style modification has shown to be beneficiary for patients with osteoartritis to improve musculoskeletal and bone health and reduce disability,according to the University of Tasmania(276). Modern herbal and TCM medicine specialists may suggest the following
1. Lose some weight
Over weight and obesity are found to associate the risk factors and risks of rapid progression of the disease(277)(278). In the discussion of obesity versus osteoarthritis, Dr. Sartori-Cintra AR and the research team at Universidade Estadual de Campinas, indicated that obesity is associated to wide range of diseases, such as osteometabolic diseases, including osteoporosis and osteoarthritis and suggested that physical activity combined with changes in diet composition can reverse the inflammatory and leptin resistance, reducing progression or preventing the onset of osteoarthritis(236).
2. Exercise
Exercise, today is less popular leisure-time activity in many countries throughout the Western world, especially in the youth due to promotion of information collection through mobile phone. According to study, moderate exercise, reduced the risk on the onset and progression of osteoarthritis joint disease(279). According to Boston University Arthritis, habitual physical activity post no risk of knee OA for men or women, during the 18th biennial examination (1983-85), in the study of 1,415 subjects had a mean age of 73 years(279). Walking is found to be the most preference of aerobic exercise tested in the older with knee osteoarthritis, depending to the distance, walking distance improves 26%, 31%, and 15% of pain and physical function, according to Dr.Stephen P. Messier,
Ph.D(280).
Combination of weight loss and exercise in older adults with knee osteoarthritis showed to improve level of leptin of which related to the biomarkers for earlier diagnosis in patient with OA(281).
Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer recommended by Kyle J. Norton
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
References
(1) Prevalence of rheumatic symptoms, rheumatoid arthritis, ankylosing spondylitis, and gout in Shanghai, China: a COPCORD study by Dai SM1, Han XH, Zhao DB, Shi YQ, Liu Y, Meng JM.(PubMed)
(2) Musculoskeletal Disorders in the Elderly by Ramon Gheno, Juan M. Cepparo, Cristina E. Rosca,1 and Anne Cotten(PMC)
(3) The effect of osteoarthritis definition on prevalence and incidence estimates: a systematic review by Pereira D1, Peleteiro B, Araújo J, Branco J, Santos RA, Ramos E.(PubMed)
(4) Effect of therapeutic aquatic exercise on symptoms and function associated with lower limb osteoarthritis: systematic review with meta-analysis by Waller B1, Ogonowska-Slodownik A2, Vitor M3, Lambeck J4, Daly D5, Kujala UM6, Heinonen A7.(PubMed)
(5) Effects of therapeutic ultrasound on pain, physical functions and safety outcomes in patients with kneeosteoarthritis: A systematic review and meta-analysis by Zhang C1, Xie Y2, Luo X3, Ji Q3, Lu C3, He C4, Wang P3.(PubMed)
(6) Oral intake of purple passion fruit peel extract reduces pain and stiffness and improves physical function in adult patients with knee osteoarthritis by Farid R1, Rezaieyazdi Z, Mirfeizi Z, Hatef MR, Mirheidari M, Mansouri H, Esmaelli H, Bentley G, Lu Y, Foo Y, Watson RR.(PubMed)
(7) Functional ability, mobility, and pain before and after knee replacement in patients aged 75 and older: a cross-sectional study by Limnell K1, Jämsen E, Huhtala H, Jäntti P, Puolakka T, Jylhä M.(PubMed)
(8) The symptoms of OA and the genesis of pain by David J. Hunter, MBBS PhD,1,2 Jason J. McDougall, BSc PhD,3 and Francis J. Keefe4(PubMed)
(276) Lifestyle modifications to improve musculoskeletal and bone health and reduce disability--a life-course approach by Jones G1, Winzenberg TM2, Callisaya ML3, Laslett LL4.(PubMed)
(277) Weight loss reduces knee-joint loads in overweight and obese older adults with knee osteoarthritis by Messier SP1, Gutekunst DJ, Davis C, DeVita P.(PubMed)
(278) Effect of weight reduction in obese patients diagnosed with knee osteoarthritis: a systematic review and meta-analysis by Christensen R1, Bartels EM, Astrup A, Bliddal H.(PubMed)
(279) Exercise and osteoarthritis by David J Hunter1,2 and Felix Eckstein3,4(PMC)
(280) Diet and Exercise for Obese Adults with Knee Osteoarthritis by Stephen P. Messier, Ph.D(PMC)
(281)Adipokines: Biomarkers for osteoarthritis? by Thitiya Poonpet and Sittisak Honsawek(PMC)
The Best Smoothie of Blueberry for Treatment of early stage of Breast Cancer: Lobular carcinoma in situ (LCIS)
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
The finding the natural ingredients for treatment of Lobular carcinoma in situ (LCIS) is considered as a dream of many scientist to replace the long term usage adverse effect of conventional medicine to other organs in the body. Unfortunately, many compounds found effective in initial studying failed to confirm the potential in large sample size and multi center.
Lobular carcinoma in situ (LCIS) is a pre cancerous condition of abnormal cells formed in the lobules or milk glands in the breast not spreading to nearby tissues or beyond. Women with lobular carcinoma in situ (LCIS) are at 7 -11 times of increased risk of developed invasive breast cancer, according to American Cancer Society.
Since lobular carcinoma in situ (LCIS) is localized cancer with tendency to travel to distance from the tissue of originated, blueberry smoothie for reduced risk and treatment of Breast Cancer may also be effective for prevention of lobular carcinoma in situ (LCIS) to become cancerously.
The smoothie for reduced risk and Treatment of Lobular carcinoma in situ (LCIS), an early stage of breast cancer
Yield: 2 serving (about 8 ounce each)
1 1/2 cups Blueberries
1 cup rice milk
4-6 ice cubes
1. Place all the ingredients in a blender.
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately.
The dream of finding of a natural ingredient for replacement of serious side effects of chemotherapy for treatment of breast caner has been extremely difficult, probably due to physical differences in testing subjects.
Breast cancer (malignant breast neoplasm) is a cancer originated in the tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma).
In 2010, over 250,000 new cases of breast cancer were diagnosed in women in the U.S. alone and the risk of getting invasive breast cancer during life time of a women is 1/8.
Blueberry, a flower plant, belong to the family Eriaceae and native to Northern America contains several essential phytochemicals and nutrients, including, lutein and zeaxanthin, zinc, potassium, phosphorus, iron, calcium and vitamins.
Blueberry or whole blueberry powder may hold a key for reduced risk breast cancer and for treatment of the diseases. Recent studies insisted that intake of the fruits and the fruit products showed to the improve the survival rate of women with breast cancer.
In estrogen-mediated breast cancer, blueberry-supplemented diet protect women against breast cancer induced by 17β-estradiol (E2)-mediated mammary tumorigenesis(breast cancer)(1) in animals received 5% blueberry diet, either 2 weeks prior to or 12 weeks study.Dr. Ravoori S and the research team at the University of Louisville suggested, the effectiveness of blue berry for treatment of breast cancer may be a result of the exhibition of its phytochemicals reducing mammary tissue proliferation and tumor burden, tumor latency(2).
In fact the intake of berries reduced significantly mammary tumor incidence (10-30%) by suppressing the levels of E(2) to prevent the early onset of E(2) breast cancer(3).
Dr. Aiyer HS and Gupta RC. said, blueberries and other berries promote anti proliferation and apoptosis of breast cancer cell is due its effects in modulating enzymes of estrogen metabolism.
In breast cancer cell lines MCF7 and MDA-MB-231, pterostilbene, a phytochemical found in blueberries, effectively suppressed tumorigenesis and metastasis of cancer stem cells (CSCs) through reduced expressions in promoted(4) and increased tumor cell proliferation of breast cancer(5).
Addition to that, the joint study lead by the Indian Institute of Technology Roorkee showed that pterostilbene not only expressed itself as a effective inducer of apoptosis in human breast in affecting various cellular targets, it also may be a chemopreventive potential based on its stronger anti-proinflammatory cytokines and anti-inflammatory activities against many forms of diseases(6).
In the study of MCF7, Hs578t and MDA-MB-231 breast cancercell lines, pterostilbene suppressed tumor growth and metastasis in MDA-MB-231, the triple-negative breast cancer and Hs578t cells through inhibition of the migratory and invasive potential by blocking the initiate the metastatic process(7).
Further more, the phytochemical also found to inhibit breast cancer regardless of estrogen receptor (ER-α36 positive or negative breast cancer)status by inducing apoptosis(8) and anti-proliferation(9), with or without the execution of cell death in apoptotic cells(8).
The finding of the effectiveness of blueberry and its phytochemical pterostilbene may serve as a cornerstone of pharmaceutical target for further studies as well as a protential medication for treatment of breast disease.
Women who are at high risk of breast cancer such as genetic mutation genes BRCA1 and BRCA2 should drink at least one cup daily and women with breast cancer should drink the juices as much as they can depending to digestive toleration.
All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to General health http://kylejnorton.blogspot.ca/p/general-health.html
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
References
(1) Chemopreventive and therapeutic activity of dietary blueberry against estrogen-mediated breast cancer by Jeyabalan J1, Aqil F, Munagala R, Annamalai L, Vadhanam MV, Gupta RC.(PubMed)
(2) Inhibition of estrogen-mediated mammary tumorigenesis by blueberry and black raspberry by Ravoori S1, Vadhanam MV, Aqil F, Gupta RC.(PubMed)
(3) Berries and ellagic acid prevent estrogen-induced mammary tumorigenesis by modulating enzymes of estrogen metabolism by Aiyer HS1, Gupta RC.(PubMed)
(4) Pterostilbene, a bioactive component of blueberries, suppresses the generation of breast cancer stem cells within tumor microenvironment and metastasis via modulating NF-κB/microRNA 448 circuit by Mak KK1, Wu AT, Lee WH, Chang TC, Chiou JF, Wang LS, Wu CH, Huang CY, Shieh YS, Chao TY, Ho CT, Yen GC, Yeh CT.(PubMed)
(5) Twist modulates breast cancer stem cells by transcriptional regulation of CD24 expression by Vesuna F1, Lisok A, Kimble B, Raman V.(PubMed)
(6) Understanding the mode of action of a pterostilbene derivative as anti-inflammatory agent by Nikhil K1, Sharan S1, Palla SR2, Sondhi SM2, Peddinti RK2, Roy P3.(PubMed)
(7) Pterostilbene inhibits triple-negative breast cancer metastasis via inducing microRNA-205 expression and negatively modulates epithelial-to-mesenchymal transition by Su CM1, Lee WH2, Wu AT3, Lin YK4, Wang LS5, Wu CH6, Yeh CT7.(PubMed)
(8) Estrogen receptor-α36 is involved in pterostilbene-induced apoptosis and anti-proliferation in in vitro and in vivobreast cancer by Pan C1, Hu Y2, Li J3, Wang Z4, Huang J5, Zhang S1, Ding L5.(PubMed)
(9) Estrogen receptor-α36 is involved in pterostilbene-induced apoptosis and anti-proliferation in in vitro and in vivobreast cancer by Pan C1, Hu Y2, Li J3, Wang Z4, Huang J5, Zhang S1, Ding L5.(PubMed)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
The finding the natural ingredients for treatment of Lobular carcinoma in situ (LCIS) is considered as a dream of many scientist to replace the long term usage adverse effect of conventional medicine to other organs in the body. Unfortunately, many compounds found effective in initial studying failed to confirm the potential in large sample size and multi center.
Lobular carcinoma in situ (LCIS) is a pre cancerous condition of abnormal cells formed in the lobules or milk glands in the breast not spreading to nearby tissues or beyond. Women with lobular carcinoma in situ (LCIS) are at 7 -11 times of increased risk of developed invasive breast cancer, according to American Cancer Society.
Since lobular carcinoma in situ (LCIS) is localized cancer with tendency to travel to distance from the tissue of originated, blueberry smoothie for reduced risk and treatment of Breast Cancer may also be effective for prevention of lobular carcinoma in situ (LCIS) to become cancerously.
The smoothie for reduced risk and Treatment of Lobular carcinoma in situ (LCIS), an early stage of breast cancer
Yield: 2 serving (about 8 ounce each)
1 1/2 cups Blueberries
1 cup rice milk
4-6 ice cubes
1. Place all the ingredients in a blender.
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately.
The dream of finding of a natural ingredient for replacement of serious side effects of chemotherapy for treatment of breast caner has been extremely difficult, probably due to physical differences in testing subjects.
Breast cancer (malignant breast neoplasm) is a cancer originated in the tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma).
In 2010, over 250,000 new cases of breast cancer were diagnosed in women in the U.S. alone and the risk of getting invasive breast cancer during life time of a women is 1/8.
Blueberry, a flower plant, belong to the family Eriaceae and native to Northern America contains several essential phytochemicals and nutrients, including, lutein and zeaxanthin, zinc, potassium, phosphorus, iron, calcium and vitamins.
Blueberry or whole blueberry powder may hold a key for reduced risk breast cancer and for treatment of the diseases. Recent studies insisted that intake of the fruits and the fruit products showed to the improve the survival rate of women with breast cancer.
In estrogen-mediated breast cancer, blueberry-supplemented diet protect women against breast cancer induced by 17β-estradiol (E2)-mediated mammary tumorigenesis(breast cancer)(1) in animals received 5% blueberry diet, either 2 weeks prior to or 12 weeks study.Dr. Ravoori S and the research team at the University of Louisville suggested, the effectiveness of blue berry for treatment of breast cancer may be a result of the exhibition of its phytochemicals reducing mammary tissue proliferation and tumor burden, tumor latency(2).
In fact the intake of berries reduced significantly mammary tumor incidence (10-30%) by suppressing the levels of E(2) to prevent the early onset of E(2) breast cancer(3).
Dr. Aiyer HS and Gupta RC. said, blueberries and other berries promote anti proliferation and apoptosis of breast cancer cell is due its effects in modulating enzymes of estrogen metabolism.
In breast cancer cell lines MCF7 and MDA-MB-231, pterostilbene, a phytochemical found in blueberries, effectively suppressed tumorigenesis and metastasis of cancer stem cells (CSCs) through reduced expressions in promoted(4) and increased tumor cell proliferation of breast cancer(5).
Addition to that, the joint study lead by the Indian Institute of Technology Roorkee showed that pterostilbene not only expressed itself as a effective inducer of apoptosis in human breast in affecting various cellular targets, it also may be a chemopreventive potential based on its stronger anti-proinflammatory cytokines and anti-inflammatory activities against many forms of diseases(6).
In the study of MCF7, Hs578t and MDA-MB-231 breast cancercell lines, pterostilbene suppressed tumor growth and metastasis in MDA-MB-231, the triple-negative breast cancer and Hs578t cells through inhibition of the migratory and invasive potential by blocking the initiate the metastatic process(7).
Further more, the phytochemical also found to inhibit breast cancer regardless of estrogen receptor (ER-α36 positive or negative breast cancer)status by inducing apoptosis(8) and anti-proliferation(9), with or without the execution of cell death in apoptotic cells(8).
The finding of the effectiveness of blueberry and its phytochemical pterostilbene may serve as a cornerstone of pharmaceutical target for further studies as well as a protential medication for treatment of breast disease.
Women who are at high risk of breast cancer such as genetic mutation genes BRCA1 and BRCA2 should drink at least one cup daily and women with breast cancer should drink the juices as much as they can depending to digestive toleration.
All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to General health http://kylejnorton.blogspot.ca/p/general-health.html
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
References
(1) Chemopreventive and therapeutic activity of dietary blueberry against estrogen-mediated breast cancer by Jeyabalan J1, Aqil F, Munagala R, Annamalai L, Vadhanam MV, Gupta RC.(PubMed)
(2) Inhibition of estrogen-mediated mammary tumorigenesis by blueberry and black raspberry by Ravoori S1, Vadhanam MV, Aqil F, Gupta RC.(PubMed)
(3) Berries and ellagic acid prevent estrogen-induced mammary tumorigenesis by modulating enzymes of estrogen metabolism by Aiyer HS1, Gupta RC.(PubMed)
(4) Pterostilbene, a bioactive component of blueberries, suppresses the generation of breast cancer stem cells within tumor microenvironment and metastasis via modulating NF-κB/microRNA 448 circuit by Mak KK1, Wu AT, Lee WH, Chang TC, Chiou JF, Wang LS, Wu CH, Huang CY, Shieh YS, Chao TY, Ho CT, Yen GC, Yeh CT.(PubMed)
(5) Twist modulates breast cancer stem cells by transcriptional regulation of CD24 expression by Vesuna F1, Lisok A, Kimble B, Raman V.(PubMed)
(6) Understanding the mode of action of a pterostilbene derivative as anti-inflammatory agent by Nikhil K1, Sharan S1, Palla SR2, Sondhi SM2, Peddinti RK2, Roy P3.(PubMed)
(7) Pterostilbene inhibits triple-negative breast cancer metastasis via inducing microRNA-205 expression and negatively modulates epithelial-to-mesenchymal transition by Su CM1, Lee WH2, Wu AT3, Lin YK4, Wang LS5, Wu CH6, Yeh CT7.(PubMed)
(8) Estrogen receptor-α36 is involved in pterostilbene-induced apoptosis and anti-proliferation in in vitro and in vivobreast cancer by Pan C1, Hu Y2, Li J3, Wang Z4, Huang J5, Zhang S1, Ding L5.(PubMed)
(9) Estrogen receptor-α36 is involved in pterostilbene-induced apoptosis and anti-proliferation in in vitro and in vivobreast cancer by Pan C1, Hu Y2, Li J3, Wang Z4, Huang J5, Zhang S1, Ding L5.(PubMed)
Most Common Diseases of 50plus: Pulmonary vascular disease(Respiratory disease): Pulmonary edema- The Complications
Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Respiratory Disease
Respiratory Disease is defined as medical conditions, affecting the breathing organ and tissues including Inflammatory lung disease, Obstructive lung diseases, Restrictive lung diseases, Respiratory tract infections, trachea, bronchi, bronchioles, alveoli, the nerves and muscles breathing, etc,.
Pulmonary vascular disease: Pulmonary edema
Pulmonary vascular disease is defined as a condition of blood flow to the lung’s artery is blocked suddenly due to a blood clot somewhere in the body, including pulmonary embolism, chronic thromboembolic disease, pulmonary arterial hypertension, pulmonary veno-occlusive disease, pulmonary arteriovenous malformations, pulmonary edema, etc.
Pulmonary edema is defined as a condition of fluid accumulation in the air spaces and parenchyma of the lungs of that can lead to difficult of breathing and respiratory failure.
The Complications
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Respiratory Disease
Respiratory Disease is defined as medical conditions, affecting the breathing organ and tissues including Inflammatory lung disease, Obstructive lung diseases, Restrictive lung diseases, Respiratory tract infections, trachea, bronchi, bronchioles, alveoli, the nerves and muscles breathing, etc,.
Pulmonary vascular disease: Pulmonary edema
Pulmonary vascular disease is defined as a condition of blood flow to the lung’s artery is blocked suddenly due to a blood clot somewhere in the body, including pulmonary embolism, chronic thromboembolic disease, pulmonary arterial hypertension, pulmonary veno-occlusive disease, pulmonary arteriovenous malformations, pulmonary edema, etc.
Pulmonary edema is defined as a condition of fluid accumulation in the air spaces and parenchyma of the lungs of that can lead to difficult of breathing and respiratory failure.
The Complications
1. Acute heart attack (myocardial infarction [MI])
According to the article by American medical network, typical causes of acute cardiogenic pulmonary edema include acute myocardial infarction or severe ischemia, exacerbation of chronic heart failure, acute volume overload of the left ventricle (valvular regurgitation), and mitral stenosis(11).
2. Cardiogenic shock
According to the study to identify the independent predictors of 30-day mortality and to analyse the outcomes of patients with cardiogenic shock (CS) associated with acute myocardial infarction (AMI) and necessitating extracorporeal life support (ECLS), of a total 77 patients who had required ECLS support for AMI with CS, Pulmonary oedema occurred in 24 patients (31.6%)(12).
3. Arrhythmias
In Thirty cases (23 males) of post cardioversion acute pulmonary edema identified with the mean age was 53.8 +/- 13 years (range, 18 to 75 years), underlying arrhythmias were atrial fibrillation (69%), atrial flutter (24%), supraventricular tachycardia (4%), and ventricular tachycardia (4%). The duration of arrhythmia preceding cardioversion varied widely ranging from 1 day to 13 years, according to Beth Israel Medical Cente(13).
4. Electrolyte disturbances
According to the article of Fluid and Electrolyte Regulation by Kathryn E.Roberts, respiratory system examination includes an assessment of thepatient’s respiratory effort, an increaseor decrease in respiratory rate and depth, and work of breathing.The presence of rales on auscultation, indicating fluid volume excess, is observed(14).
5. Protein enteropathyIn the differential diagnosis, protein-losing enteropathy (PLE) is a rarely considered explanation of edema. Three such cases are reported in this the study by the Kaohsiung Medical University(15).
6. Death.
All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Sources
(a) http://www.ncbi.nlm.nih.gov/pubmed/19739476
(11) http://www.health.am/cardio/more/acute_heart_failure_pulmonary_edema/
(12) http://www.ncbi.nlm.nih.gov/pubmed/23616484
(13) http://www.ncbi.nlm.nih.gov/pubmed/14659864
(14) http://repository.upenn.edu/cgi/viewcontent.cgi?filename=10&article=1003&context=miscellaneous_papers&type=additional
(15) http://www.ncbi.nlm.nih.gov/pubmed/12036201
According to the article by American medical network, typical causes of acute cardiogenic pulmonary edema include acute myocardial infarction or severe ischemia, exacerbation of chronic heart failure, acute volume overload of the left ventricle (valvular regurgitation), and mitral stenosis(11).
2. Cardiogenic shock
According to the study to identify the independent predictors of 30-day mortality and to analyse the outcomes of patients with cardiogenic shock (CS) associated with acute myocardial infarction (AMI) and necessitating extracorporeal life support (ECLS), of a total 77 patients who had required ECLS support for AMI with CS, Pulmonary oedema occurred in 24 patients (31.6%)(12).
3. Arrhythmias
In Thirty cases (23 males) of post cardioversion acute pulmonary edema identified with the mean age was 53.8 +/- 13 years (range, 18 to 75 years), underlying arrhythmias were atrial fibrillation (69%), atrial flutter (24%), supraventricular tachycardia (4%), and ventricular tachycardia (4%). The duration of arrhythmia preceding cardioversion varied widely ranging from 1 day to 13 years, according to Beth Israel Medical Cente(13).
4. Electrolyte disturbances
According to the article of Fluid and Electrolyte Regulation by Kathryn E.Roberts, respiratory system examination includes an assessment of thepatient’s respiratory effort, an increaseor decrease in respiratory rate and depth, and work of breathing.The presence of rales on auscultation, indicating fluid volume excess, is observed(14).
5. Protein enteropathyIn the differential diagnosis, protein-losing enteropathy (PLE) is a rarely considered explanation of edema. Three such cases are reported in this the study by the Kaohsiung Medical University(15).
6. Death.
All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Sources
(a) http://www.ncbi.nlm.nih.gov/pubmed/19739476
(11) http://www.health.am/cardio/more/acute_heart_failure_pulmonary_edema/
(12) http://www.ncbi.nlm.nih.gov/pubmed/23616484
(13) http://www.ncbi.nlm.nih.gov/pubmed/14659864
(14) http://repository.upenn.edu/cgi/viewcontent.cgi?filename=10&article=1003&context=miscellaneous_papers&type=additional
(15) http://www.ncbi.nlm.nih.gov/pubmed/12036201
Friday, April 8, 2016
Most Common Disease of 50Plus: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Osteoarthritis: Medication and Surgical Treatment in Conventional Medicine
Kyle J. Norton (Scholar)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Musculoskeletal disorders (MSDs) are medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed. A major restriction of joint movement range was frequent in the shoulder but uncommon in other joints(1).
Types of Musculo-Skeletal disorders in elder(2)
1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia
Osteoarthritis
Osteoarthritis (OA), a form of arthritis, is defined as a condition of as a result of aging causes of wear and tear on a joint, affecting over 25 million people in the United States in alone. University of Porto Medical School indicated that one must understand the differences in prevalence and incidence estimates of osteoarthritis (OA), according to case definition, in knee, hip and hand joints(3).
The characteristics of osteoarthritis are aching pain(5), stiffness(6), or difficulty of moving the joint or joints(7). The pain usually gets worse in change of weather, at night and in the advanced diseases, the pain can occur even at rest(8). Today management of osteoarthritis (OA) focuses on pain relief and improved physical function through pharmacological, non pharmacological, and surgical treatments(4).
The Treatment
A. In conventional medicine
2. Medication
Medication or combined medication are used to stop the progression and relieve the symptoms of the diseases may include
2.1. Medication for reduced symptoms
Nonsteroidal anti-inflammatory drugs (NSAIDs)can be bought as over counter medicine for reduced pain and inflammation for patient with rheumatoid arthritis with an incidence of significant upper GI toxic effects, according to a total of 8059 patients (>/=18 years old) with osteoarthritis (OA) or rheumatoid arthritis (RA)(186). Dr. Wienecke T and Dr. Gøtzsche PC. in the comparison of NSAIDs and Paracetamol for treatment of RA said " There is a need for a large trial, with appropriate randomisation, double-blinding, test of the success of the blinding, and with explicit methods to measure and analyse pain and adverse effects"(187) due to favorable of onsteroidal anti-inflammatory drugs (NSAIDs) in general population.
2.2. Medication for interfering the disease progression
a. Corticosteroids
Corticosteroid, a class a class of chemicals including the steroid hormones medication prednisone, prednisolone and methyprednisolone have been used in conventional medicine for quick treatment of inflammatory diseases such as rheumatoid arthritis, through reduced in activity and expression as a result of oxidative/nitrative stress(188). The University de Montréal joint study of 838 patient indicated the effectiveness of corticosteroids for treatment of inflammation of RA may accompany with increased hazard of infection(189), risk for the development of secondary osteoporosis(190) and dyslipidemia and hypertension(192). adrenal suppression, bone loss, skin thinning, increased cataract formation, decreased linear growth in children, metabolic changes, and behavioral abnormalities(191).
b. DMARDs, (Disease-modifying antirheumatic drugs)
DMARDs, a disease-modifying antirheumatic drug such as methotrexate, hydroxycholorquine, sulfasalazine, leflunomide used by conventional doctor to modify the course of the disease(RA in this case) by releasing 4 h later to coincide with the rise of nocturnal inflammatory cytokines associated with development of symptoms of RA(192). According to the report of Dr. Sitzia J and Dr. Huggins L. the adverse effects of DMARDs may include alopecia, fatigue, weight gain with fatigue and nausea to be the "most troublesome" problems, followed by difficulty sleeping and sore eyes(193), as well as other incidences of gastrointestinal side effects(194).
c. Biologics
Biologics including abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, infliximab, golimumab and rituximab works with similar effects as DMARDs but more quickly in blocking a specific step in the inflammation process, such as blocking the activation of T cells(197), B cells(198), pro inflammatory cytokines(199),...... have found significantly improved outcomes for patients with rheumatoid arthritis(195), through reducing the signs and symptoms of RA, slowing radiographic progression of joint destruction, and improving physical function and quality of life in patients with RA(196).
d. JAK inhibitors
JAK inhibitors, the medication used in conventional doctors for inhibition of the activity of one or more of the Janus kinase family of enzymes, involving function in cytokine receptor signalling pathway, through interaction with signal transducers(transmission of molecularsignals from a cell's exterior to its interior) and activators of transcription proteins(a sequence-specific DNA-binding factor in controlling the rate of transcription of genetic information from DNA to messenger RNA)(200) is also known as a new subcategory of DMARDs. Dr. Norman P. said" JAK inhibitors differ in isoform specificity profiles, with good efficacy achievable by selective inhibition of either JAK1 (filgotinib or INCB-039110) or JAK3 (decernotinib)' of that contrite to the effective treatment of patient with rheumatoid arthritis)(201). According to the University of Occupational and Environmental Health, use of Tofacitinib, a new class of DMARDs orally available exhibited a strong clinical efficacy similar to biologic DMARDs through inhibited multiple cytokines and signaling pathways at clinical doses that are in contrast to biological DMARDs(202).
Here, we quoted the criteria of medication or combined medication is used to stop the progression and relieve the symptoms of RA by Dr. da Mota LM, and scientists at the Universidade de Brasília
1) The therapeutic decision should be shared with the patient;
2) Immediately after the diagnosis, a disease-modifying antirheumatic drug (DMARD) should be prescribed, and the treatment adjusted to achieve remission;
3) Treatment should be conducted by a rheumatologist;
4) The initial treatment includes synthetic DMARDs;
5) Methotrexate is the drug of choice;
6) Patients who fail to respond after two schedules of synthetic DMARDsshould be assessed for the use of biologic DMARDs;
7) Exceptionally, biologic DMARDs can be considered earlier;
8) Anti-TNF agents are preferentially recommended as the initial biologic therapy; 9) after therapeutic failure of a first biologic DMARD, other biologics can be used;
10) Cyclophosphamide and azathioprine can be used in severe extra-articular manifestations;
11) Oral corticoid is recommended at low doses and for short periods of time;
12) Non-steroidal anti-inflammatory drugs should always be prescribed in association with a DMARD; 13) clinical assessments should be performed on a monthly basis at the beginning of treatment;
14) Physical therapy, rehabilitation, and occupational therapy are indicated;
15) Surgical treatment is recommended to correct sequelae;
16) Alternative therapy does not replace traditional therapy;
17) Family planning is recommended;
18) The active search and management of comorbidities are recommended;
19) The patient’s vaccination status should be recorded and updated;
20) Endemic-epidemic transmissible diseases should be investigated and treated.
3. Surgery
Surgery in some cases may be necessary to relieve severe pain and extensive joint deformities and with patient do not response to non and medical treatment. According to the Wrightington Hospital NHS Trust, in the study of postoperative infection or surgical complications occurring within one year of surgery in patient with RA found that the surgical procedure induced 27% of infection and complication for patient with different in the intake of Methotrexate(204), a synthetic compound used for treatment of some forms of cancers.
Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer recommended by Kyle J. Norton
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
References
(1) 8 Areas of Age-Related Change(NIH)
(2) Arthritis-Related Statistics(CDC)
(3) Valgus deformities of the feet and characteristics of gait in patients who have rheumatoid arthritis by Keenan MA1, Peabody TD, Gronley JK, Perry J.(PubMed)
(4) Serum Sclerostin Level Among Egyptian Rheumatoid Arthritis Patients: Relation to Disease Activity ,Bone Mineral Density and Radiological Grading by Mehaney DA, Eissa M, Anwar S, El-Din SF(PubMed)
(4a) Death rates and causes of death in patients with rheumatoid arthritis: a population-based study by Sihvonen S1, Korpela M, Laippala P, Mustonen J, Pasternack A(PubMed)
(185) A randomized double-blind sham-controlled trial of the Prosorba column for treatment of refractory rheumatoid arthritis by Gendreau RM1; Prosorba Clinical Trial Group(PubMed)
(186) Gastrointestinal toxicity with celecoxib vs nonsteroidal anti-inflammatory drugs for osteoarthritis andrheumatoid arthritis: the CLASS study: A randomized controlled trial. Celecoxib Long-term Arthritis Safety Study by Silverstein FE1, Faich G, Goldstein JL, Simon LS, Pincus T, Whelton A, Makuch R, Eisen G, Agrawal NM, Stenson WF, Burr AM, Zhao WW, Kent JD, Lefkowith JB, Verburg KM, Geis GS.(PubMed)
(187) Paracetamol versus nonsteroidal anti-inflammatory drugs for rheumatoid arthritis by Wienecke T1, Gøtzsche PC.(PubMed)
(188) How corticosteroids control inflammation: Quintiles Prize Lecture 2005 by Barnes PJ1.(PubMed)
(189) Use of corticosteroids in patients with rheumatoid arthritis treated with infliximab: treatment implications based on a real-world Canadian population by Haraoui B1, Jovaisas A2, Bensen WG3, Faraawi R3, Kelsall J4, Dixit S3, Rodrigues J5, Sheriff M6, Rampakakis E7, Sampalis JS7, Lehman AJ8, Otawa S8,Nantel F8, Shawi M8.(PubMed)
(190) Adverse effects of corticosteroids on bone metabolism: a review by Mitra R1.(PubMed)
(191) Adverse effects of inhaled corticosteroids by Hanania NA1, Chapman KR, Kesten S.(PubMed)
(191) Adverse effects of corticosteroids on the cardiovascular system by Sholter DE1, Armstrong PW.(PubMed)
(192) Delayed-release prednisone improves fatigue and health-related quality of life: findings from the CAPRA-2 double-blind randomised study in rheumatoid arthritis by Alten R1, Grahn A2, Holt RJ3, Rice P4, Buttgereit F5.(PubMed)
(193) Side effects of cyclophosphamide, methotrexate, and 5-fluorouracil (CMF) chemotherapy for breast cancer by Sitzia J1, Huggins L.(PubMed)
(194) Folic acid and folinic acid for reducing side effects in patients receiving methotrexate for rheumatoid arthritis by Shea B1, Swinden MV2, Ghogomu ET2, Ortiz Z2, Katchamart W2, Rader T2, Bombardier C2, Wells GA2, Tugwell P2.(PubMed)
(195) Biologics in rheumatoid arthritis: where are we going? by Fechtenbaum M1, Nam JL, Emery P.(PubMed)
(196) Use of biologics in rheumatoid arthritis: where are we going? by Pucino F Jr1, Harbus PT, Goldbach-Mansky R.(PubMed)
(197) [Efficacy and safety of abatacept in patients with rheumatoid arthritis and no prior treatment with biologics].[Article in Spanish] by Escudero Contreras A1, Castro-Villegas MC, Hernández-Hernández MV, Díaz-González F.(PubMed)
(198) Complement activation and C3b deposition on rituximab-opsonized cells substantially blocks binding of phycoerythrin-labeled anti-mouse IgG probes to rituximab by Beum PV1, Kennedy AD, Li Y, Pawluczkowycz AW, Williams ME, Taylor RP.(PubMed)
(199) Infections and biological therapy in rheumatoid arthritis by Cunnane G1, Doran M, Bresnihan B.(PubMed)
(200) Transcription factors: An overview by David S. Latchman(Science direct)
(201) Selective JAK inhibitors in development for rheumatoid arthritis by Norman P1.(PubMed)
(202) Targeting the Janus kinases in rheumatoid arthritis: focus on tofacitinib by Yamaoka K1, Tanaka Y.(PubMed)
(203) Methotrexate and early postoperative complications in patients with rheumatoid arthritis undergoing elective orthopaedic surgery by Grennan DM1, Gray J, Loudon J, Fear S.(PubMed)
(204) 2012 Brazilian Society of Rheumatology Consensus for the treatment of rheumatoid arthritis.[Article in English, Portuguese] by da Mota LM1, Cruz BA, Brenol CV, Pereira IA, Rezende-Fronza LS, Bertolo MB, de Freitas MV, da Silva NA, Louzada-Júnior P, Giorgi RD, Lima RA, da Rocha Castelar Pinheiro G; Brazilian Society of Rheumatology.(PubMed)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Musculoskeletal disorders (MSDs) are medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed. A major restriction of joint movement range was frequent in the shoulder but uncommon in other joints(1).
Types of Musculo-Skeletal disorders in elder(2)
1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia
Osteoarthritis
Osteoarthritis (OA), a form of arthritis, is defined as a condition of as a result of aging causes of wear and tear on a joint, affecting over 25 million people in the United States in alone. University of Porto Medical School indicated that one must understand the differences in prevalence and incidence estimates of osteoarthritis (OA), according to case definition, in knee, hip and hand joints(3).
The characteristics of osteoarthritis are aching pain(5), stiffness(6), or difficulty of moving the joint or joints(7). The pain usually gets worse in change of weather, at night and in the advanced diseases, the pain can occur even at rest(8). Today management of osteoarthritis (OA) focuses on pain relief and improved physical function through pharmacological, non pharmacological, and surgical treatments(4).
The Treatment
A. In conventional medicine
2. Medication
Medication or combined medication are used to stop the progression and relieve the symptoms of the diseases may include
2.1. Medication for reduced symptoms
Nonsteroidal anti-inflammatory drugs (NSAIDs)can be bought as over counter medicine for reduced pain and inflammation for patient with rheumatoid arthritis with an incidence of significant upper GI toxic effects, according to a total of 8059 patients (>/=18 years old) with osteoarthritis (OA) or rheumatoid arthritis (RA)(186). Dr. Wienecke T and Dr. Gøtzsche PC. in the comparison of NSAIDs and Paracetamol for treatment of RA said " There is a need for a large trial, with appropriate randomisation, double-blinding, test of the success of the blinding, and with explicit methods to measure and analyse pain and adverse effects"(187) due to favorable of onsteroidal anti-inflammatory drugs (NSAIDs) in general population.
2.2. Medication for interfering the disease progression
a. Corticosteroids
Corticosteroid, a class a class of chemicals including the steroid hormones medication prednisone, prednisolone and methyprednisolone have been used in conventional medicine for quick treatment of inflammatory diseases such as rheumatoid arthritis, through reduced in activity and expression as a result of oxidative/nitrative stress(188). The University de Montréal joint study of 838 patient indicated the effectiveness of corticosteroids for treatment of inflammation of RA may accompany with increased hazard of infection(189), risk for the development of secondary osteoporosis(190) and dyslipidemia and hypertension(192). adrenal suppression, bone loss, skin thinning, increased cataract formation, decreased linear growth in children, metabolic changes, and behavioral abnormalities(191).
b. DMARDs, (Disease-modifying antirheumatic drugs)
DMARDs, a disease-modifying antirheumatic drug such as methotrexate, hydroxycholorquine, sulfasalazine, leflunomide used by conventional doctor to modify the course of the disease(RA in this case) by releasing 4 h later to coincide with the rise of nocturnal inflammatory cytokines associated with development of symptoms of RA(192). According to the report of Dr. Sitzia J and Dr. Huggins L. the adverse effects of DMARDs may include alopecia, fatigue, weight gain with fatigue and nausea to be the "most troublesome" problems, followed by difficulty sleeping and sore eyes(193), as well as other incidences of gastrointestinal side effects(194).
c. Biologics
Biologics including abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, infliximab, golimumab and rituximab works with similar effects as DMARDs but more quickly in blocking a specific step in the inflammation process, such as blocking the activation of T cells(197), B cells(198), pro inflammatory cytokines(199),...... have found significantly improved outcomes for patients with rheumatoid arthritis(195), through reducing the signs and symptoms of RA, slowing radiographic progression of joint destruction, and improving physical function and quality of life in patients with RA(196).
d. JAK inhibitors
JAK inhibitors, the medication used in conventional doctors for inhibition of the activity of one or more of the Janus kinase family of enzymes, involving function in cytokine receptor signalling pathway, through interaction with signal transducers(transmission of molecularsignals from a cell's exterior to its interior) and activators of transcription proteins(a sequence-specific DNA-binding factor in controlling the rate of transcription of genetic information from DNA to messenger RNA)(200) is also known as a new subcategory of DMARDs. Dr. Norman P. said" JAK inhibitors differ in isoform specificity profiles, with good efficacy achievable by selective inhibition of either JAK1 (filgotinib or INCB-039110) or JAK3 (decernotinib)' of that contrite to the effective treatment of patient with rheumatoid arthritis)(201). According to the University of Occupational and Environmental Health, use of Tofacitinib, a new class of DMARDs orally available exhibited a strong clinical efficacy similar to biologic DMARDs through inhibited multiple cytokines and signaling pathways at clinical doses that are in contrast to biological DMARDs(202).
Here, we quoted the criteria of medication or combined medication is used to stop the progression and relieve the symptoms of RA by Dr. da Mota LM, and scientists at the Universidade de Brasília
1) The therapeutic decision should be shared with the patient;
2) Immediately after the diagnosis, a disease-modifying antirheumatic drug (DMARD) should be prescribed, and the treatment adjusted to achieve remission;
3) Treatment should be conducted by a rheumatologist;
4) The initial treatment includes synthetic DMARDs;
5) Methotrexate is the drug of choice;
6) Patients who fail to respond after two schedules of synthetic DMARDsshould be assessed for the use of biologic DMARDs;
7) Exceptionally, biologic DMARDs can be considered earlier;
8) Anti-TNF agents are preferentially recommended as the initial biologic therapy; 9) after therapeutic failure of a first biologic DMARD, other biologics can be used;
10) Cyclophosphamide and azathioprine can be used in severe extra-articular manifestations;
11) Oral corticoid is recommended at low doses and for short periods of time;
12) Non-steroidal anti-inflammatory drugs should always be prescribed in association with a DMARD; 13) clinical assessments should be performed on a monthly basis at the beginning of treatment;
14) Physical therapy, rehabilitation, and occupational therapy are indicated;
15) Surgical treatment is recommended to correct sequelae;
16) Alternative therapy does not replace traditional therapy;
17) Family planning is recommended;
18) The active search and management of comorbidities are recommended;
19) The patient’s vaccination status should be recorded and updated;
20) Endemic-epidemic transmissible diseases should be investigated and treated.
3. Surgery
Surgery in some cases may be necessary to relieve severe pain and extensive joint deformities and with patient do not response to non and medical treatment. According to the Wrightington Hospital NHS Trust, in the study of postoperative infection or surgical complications occurring within one year of surgery in patient with RA found that the surgical procedure induced 27% of infection and complication for patient with different in the intake of Methotrexate(204), a synthetic compound used for treatment of some forms of cancers.
Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer recommended by Kyle J. Norton
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
References
(1) 8 Areas of Age-Related Change(NIH)
(2) Arthritis-Related Statistics(CDC)
(3) Valgus deformities of the feet and characteristics of gait in patients who have rheumatoid arthritis by Keenan MA1, Peabody TD, Gronley JK, Perry J.(PubMed)
(4) Serum Sclerostin Level Among Egyptian Rheumatoid Arthritis Patients: Relation to Disease Activity ,Bone Mineral Density and Radiological Grading by Mehaney DA, Eissa M, Anwar S, El-Din SF(PubMed)
(4a) Death rates and causes of death in patients with rheumatoid arthritis: a population-based study by Sihvonen S1, Korpela M, Laippala P, Mustonen J, Pasternack A(PubMed)
(185) A randomized double-blind sham-controlled trial of the Prosorba column for treatment of refractory rheumatoid arthritis by Gendreau RM1; Prosorba Clinical Trial Group(PubMed)
(186) Gastrointestinal toxicity with celecoxib vs nonsteroidal anti-inflammatory drugs for osteoarthritis andrheumatoid arthritis: the CLASS study: A randomized controlled trial. Celecoxib Long-term Arthritis Safety Study by Silverstein FE1, Faich G, Goldstein JL, Simon LS, Pincus T, Whelton A, Makuch R, Eisen G, Agrawal NM, Stenson WF, Burr AM, Zhao WW, Kent JD, Lefkowith JB, Verburg KM, Geis GS.(PubMed)
(187) Paracetamol versus nonsteroidal anti-inflammatory drugs for rheumatoid arthritis by Wienecke T1, Gøtzsche PC.(PubMed)
(188) How corticosteroids control inflammation: Quintiles Prize Lecture 2005 by Barnes PJ1.(PubMed)
(189) Use of corticosteroids in patients with rheumatoid arthritis treated with infliximab: treatment implications based on a real-world Canadian population by Haraoui B1, Jovaisas A2, Bensen WG3, Faraawi R3, Kelsall J4, Dixit S3, Rodrigues J5, Sheriff M6, Rampakakis E7, Sampalis JS7, Lehman AJ8, Otawa S8,Nantel F8, Shawi M8.(PubMed)
(190) Adverse effects of corticosteroids on bone metabolism: a review by Mitra R1.(PubMed)
(191) Adverse effects of inhaled corticosteroids by Hanania NA1, Chapman KR, Kesten S.(PubMed)
(191) Adverse effects of corticosteroids on the cardiovascular system by Sholter DE1, Armstrong PW.(PubMed)
(192) Delayed-release prednisone improves fatigue and health-related quality of life: findings from the CAPRA-2 double-blind randomised study in rheumatoid arthritis by Alten R1, Grahn A2, Holt RJ3, Rice P4, Buttgereit F5.(PubMed)
(193) Side effects of cyclophosphamide, methotrexate, and 5-fluorouracil (CMF) chemotherapy for breast cancer by Sitzia J1, Huggins L.(PubMed)
(194) Folic acid and folinic acid for reducing side effects in patients receiving methotrexate for rheumatoid arthritis by Shea B1, Swinden MV2, Ghogomu ET2, Ortiz Z2, Katchamart W2, Rader T2, Bombardier C2, Wells GA2, Tugwell P2.(PubMed)
(195) Biologics in rheumatoid arthritis: where are we going? by Fechtenbaum M1, Nam JL, Emery P.(PubMed)
(196) Use of biologics in rheumatoid arthritis: where are we going? by Pucino F Jr1, Harbus PT, Goldbach-Mansky R.(PubMed)
(197) [Efficacy and safety of abatacept in patients with rheumatoid arthritis and no prior treatment with biologics].[Article in Spanish] by Escudero Contreras A1, Castro-Villegas MC, Hernández-Hernández MV, Díaz-González F.(PubMed)
(198) Complement activation and C3b deposition on rituximab-opsonized cells substantially blocks binding of phycoerythrin-labeled anti-mouse IgG probes to rituximab by Beum PV1, Kennedy AD, Li Y, Pawluczkowycz AW, Williams ME, Taylor RP.(PubMed)
(199) Infections and biological therapy in rheumatoid arthritis by Cunnane G1, Doran M, Bresnihan B.(PubMed)
(200) Transcription factors: An overview by David S. Latchman(Science direct)
(201) Selective JAK inhibitors in development for rheumatoid arthritis by Norman P1.(PubMed)
(202) Targeting the Janus kinases in rheumatoid arthritis: focus on tofacitinib by Yamaoka K1, Tanaka Y.(PubMed)
(203) Methotrexate and early postoperative complications in patients with rheumatoid arthritis undergoing elective orthopaedic surgery by Grennan DM1, Gray J, Loudon J, Fear S.(PubMed)
(204) 2012 Brazilian Society of Rheumatology Consensus for the treatment of rheumatoid arthritis.[Article in English, Portuguese] by da Mota LM1, Cruz BA, Brenol CV, Pereira IA, Rezende-Fronza LS, Bertolo MB, de Freitas MV, da Silva NA, Louzada-Júnior P, Giorgi RD, Lima RA, da Rocha Castelar Pinheiro G; Brazilian Society of Rheumatology.(PubMed)
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