Tuesday, April 12, 2016

Most Common Diseases of 50plus: Pulmonary vascular disease(Respiratory disease): Pulmonary edema- The Diagnosis

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

                           Respiratory Disease

Respiratory Disease is defined as medical conditions, affecting the breathing organ and tissues including Inflammatory lung disease, Obstructive lung diseases, Restrictive lung diseases, Respiratory tract infections, trachea, bronchi, bronchioles, alveoli, the nerves and muscles breathing, etc,.

         Pulmonary vascular disease:  Pulmonary edema


Pulmonary vascular disease is defined as a condition of blood flow to the lung’s artery is blocked suddenly due to a blood clot somewhere in the body, including pulmonary embolism, chronic thromboembolic disease, pulmonary arterial hypertension, pulmonary veno-occlusive disease, pulmonary arteriovenous malformations, pulmonary edema, etc.
                                                   
Pulmonary edema is defined as a condition of fluid accumulation in the air spaces and parenchyma of the lungs of that can lead to difficult of breathing and respiratory failure.

                              The  Diagnosis

If you are experience certain symptoms above and suspected to develop, after a complete physical examination, including checking the presence of fluid in your lungs and recorded of your family, the tests which your doctor orders may include
1. Blood test
Blood chemistry tests are a procedure to examine the general health of a patient, but in this case it may be used to test for oxygen levels.
2. Lung ultrasound
Neurogenic pulmonary edema (NPE) is an acute life-threatening complication associated with many forms of central nervous system injury. NPE usually appears within minutes to hours after injury and has a high mortality rate if not recognized and treated appropriately. Lung ultrasound quickly provides at the bedside relevant information on the state of aeration and ventilation of the lung(25).
3. Chest X-ray
The aim of the test is to check for the presence of fluid in the lung. According to the study by the researcher team lead by Liebman PR, the portable chest x-ray technic does not provide quantitative information regarding cardiopulmonary function. It is especially hazardous to accept an x-ray diagnosis of congestive failure as the cause of pulmonary edema(26).
4. Electrocardiogram (ECG)
The aim of the test is to look for heart rhythm problems or signs of a heart attack. There is a report of a case of presented markedly low surface electrocardiographic (ECG) voltage and an infarction pattern are rapidly reversed with renal hemodialysis for pulmonary edema(27).
5. Echocardiogram
The aim of the test is to check for problems of the heart muscle including weakness, thickness, failure to relax properly, leaky or narrow heart valves, or fluid surrounding the heart(28).

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Monday, April 11, 2016

Most Common Disease of50plus: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Osteoarthritis: Treatment In herbal and traditional Chinese medicine - Life style Modification

Kyle J. Norton (Scholar)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed. A major restriction of joint movement range was frequent in the shoulder but uncommon in other joints(1).

Types of Musculo-Skeletal disorders in elder(2)

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia



                                                      Osteoarthritis


Osteoarthritis (OA), a form of arthritis, is defined as a condition of as a result of aging causes of wear and tear on a joint, affecting over 25 million people in the United States in alone. University of Porto Medical School indicated that one must understand the differences in prevalence and incidence estimates of osteoarthritis (OA), according to case definition, in knee, hip and hand joints(3).
The characteristics of osteoarthritis are aching pain(5), stiffness(6), or difficulty of moving the joint or joints(7). The pain usually gets worse in change of weather, at night and in the advanced diseases, the pain can occur even at rest(8). Today management of osteoarthritis (OA) focuses on pain relief and improved physical function through pharmacological, non pharmacological, and surgical treatments(4).


                        The Treatment


B. In herbal and traditional Chinese medicine perspective
B.1. Life style modification according herbal and TCM medicine specialist
Life style modification has shown to be beneficiary for patients with osteoartritis to improve musculoskeletal and bone health and reduce disability,according to the University of Tasmania(276). Modern herbal and TCM medicine specialists may suggest the following
1. Lose some weight
Over weight and obesity are found to associate the risk factors and risks of rapid progression of the disease(277)(278). In the discussion of obesity versus osteoarthritis, Dr. Sartori-Cintra AR and the research team at Universidade Estadual de Campinas, indicated that obesity is associated to wide range of diseases, such as osteometabolic diseases, including osteoporosis and osteoarthritis and suggested that physical activity combined with changes in diet composition can reverse the inflammatory and leptin resistance, reducing progression or preventing the onset of osteoarthritis(236).

2. Exercise
Exercise, today is less popular leisure-time activity in many countries throughout the Western world, especially in the youth due to promotion of information collection through mobile phone. According to study, moderate exercise, reduced the risk on the onset and progression of osteoarthritis joint disease(279). According to Boston University Arthritis, habitual physical activity post no risk of knee OA for men or women, during the 18th biennial examination (1983-85), in the study of 1,415 subjects had a mean age of 73 years(279). Walking is found to be the most preference of aerobic exercise tested in the older with knee osteoarthritis, depending to the distance, walking distance improves 26%, 31%, and 15% of pain and physical function, according to Dr.Stephen P. Messier,
Ph.D(280).
Combination of weight loss and exercise in older adults with knee osteoarthritis showed to improve level of leptin of which related to the biomarkers for earlier diagnosis in patient with OA(281).



Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer recommended by Kyle J. Norton

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca


References
(1) Prevalence of rheumatic symptoms, rheumatoid arthritis, ankylosing spondylitis, and gout in Shanghai, China: a COPCORD study by Dai SM1, Han XH, Zhao DB, Shi YQ, Liu Y, Meng JM.(PubMed)
(2) Musculoskeletal Disorders in the Elderly by Ramon Gheno, Juan M. Cepparo, Cristina E. Rosca,1 and Anne Cotten(PMC)
(3) The effect of osteoarthritis definition on prevalence and incidence estimates: a systematic review by Pereira D1, Peleteiro B, Araújo J, Branco J, Santos RA, Ramos E.(PubMed)
(4) Effect of therapeutic aquatic exercise on symptoms and function associated with lower limb osteoarthritis: systematic review with meta-analysis by Waller B1, Ogonowska-Slodownik A2, Vitor M3, Lambeck J4, Daly D5, Kujala UM6, Heinonen A7.(PubMed)
(5) Effects of therapeutic ultrasound on pain, physical functions and safety outcomes in patients with kneeosteoarthritis: A systematic review and meta-analysis by Zhang C1, Xie Y2, Luo X3, Ji Q3, Lu C3, He C4, Wang P3.(PubMed)
(6) Oral intake of purple passion fruit peel extract reduces pain and stiffness and improves physical function in adult patients with knee osteoarthritis by Farid R1, Rezaieyazdi Z, Mirfeizi Z, Hatef MR, Mirheidari M, Mansouri H, Esmaelli H, Bentley G, Lu Y, Foo Y, Watson RR.(PubMed)
(7) Functional ability, mobility, and pain before and after knee replacement in patients aged 75 and older: a cross-sectional study by Limnell K1, Jämsen E, Huhtala H, Jäntti P, Puolakka T, Jylhä M.(PubMed)
(8) The symptoms of OA and the genesis of pain by David J. Hunter, MBBS PhD,1,2 Jason J. McDougall, BSc PhD,3 and Francis J. Keefe4(PubMed)
(276) Lifestyle modifications to improve musculoskeletal and bone health and reduce disability--a life-course approach by Jones G1, Winzenberg TM2, Callisaya ML3, Laslett LL4.(PubMed)
(277) Weight loss reduces knee-joint loads in overweight and obese older adults with knee osteoarthritis by Messier SP1, Gutekunst DJ, Davis C, DeVita P.(PubMed)
(278) Effect of weight reduction in obese patients diagnosed with knee osteoarthritis: a systematic review and meta-analysis by Christensen R1, Bartels EM, Astrup A, Bliddal H.(PubMed)
(279) Exercise and osteoarthritis by David J Hunter1,2 and Felix Eckstein3,4(PMC)
(280) Diet and Exercise for Obese Adults with Knee Osteoarthritis by Stephen P. Messier, Ph.D(PMC)
(281)Adipokines: Biomarkers for osteoarthritis? by Thitiya Poonpet and Sittisak Honsawek(PMC)

The Smoothie of Bell Pepper, Sweet potato and Pineapple for reduced Risk and Treatment of Irregular Menstruation

Kyle J. Norton(Scholar, Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for reduced symptoms and treatment of irregular menstruation
Yield: 2 serving (about 8 ounce each)
1/4 cup bell pepper
3/4 cup sweet potato
1/2 cup pineapple
1 cup of rice milk

1. Place all ingradietns in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed. Add more green tea drink if needed
3. Serve immediately

The dream of finding the natural ingredient for prevention and treatment of irregular menstruation without adverse effects in replacement of conventional medication has no through antioxidant t been abated. Some ingredients have to discard due to it can achieve the same potent results in human trials.

Recent studies suggested that pepper fruits (Capsicum annuum L.)(1), sweet potato(4) and pineapple(5) may have a potential and therapeutic value for reduced risk and treatment of cervical cancer probably due to theirs' phytochemicals effect in ameliorated proliferation of cancer cell expression.

Irregular menstruation or period is defined as condition in which a woman is experience abnormal variation of length of the menstrual cycle. While the normal menstrual cycle is 28-35 days, women who are experience with irregular menstrual cycle can have a length variation between 8 and 20 days or shorter than 21 days, or longer than 36 days

Phenolic acid glycossides found hot pepper fruits(1) and herbal medicine such as rhizomes of Polygonum paleaceum(2) exerted anti irregular menstruation effects through exhibition of free radical-scavenging activity(2). According to the Kunming Institute of Botany, Chinese Academy of Science, a new phenolic glycoside isolated from Balanophora involucrata HOOK.f. & THOMSON (Balanophoraceae), also displayed antioxidant properties in attenuated the expression of free radicals(3).

Vitamin E, best known for its powerful antioxidant property is a fat soluble vitamin found abundantly in sweet potato plays an essential role in regulation of normal menstrual period(4).Low serum vitamin E concentration is associated to irregular menstrual function in in athletes, according
to reported by Dr. Tomten SE Dr, Høstmark AT(4).

Melatonin, best known for its function in induced sleep, found abundantly in pineapples may also have an direct influence against irregular menstruation(5). According to the Yamaguchi University School of Medicine, abnormal plasma melatonin concentration in most of the women with an anovulatory cycle or amenorrhea was within the range of the mean level of +/- 1.5 x the standard deviation obtained from the 20 women with a regular menstrual cycle(5).

Dr.Miyauchi F and colleagues at the Ehime Rosai Hospital said, " The incidence (of irregular menstrual cycle)was significantly higher in women working at night than women working during the day" plasma concentrations of melatonin and prolactin at 0200 h were significantly lower in nurses of the working group than others of the resting group"(6).

The combination of Bell Pepper, Sweet potato and Pineapple smoothie may hold a key in further studies in production of an effective natural ingredients to reduce risk and treatment of irregular menstruation without inducing adverse effects.
Women who are at higher risk of irregular menstruation due to family history, obesity,...should take at least one serving daily. Women with irregular menstruation should drink as much as they can depending to the digestive toleration.

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
References
(1) Isolation and structure elucidation of flavonoid and phenolic acid glycosides from pericarp of hot pepper fruit Capsicum annuum L. by Materska M1, Piacente S, Stochmal A, Pizza C, Oleszek W, Perucka I.(PubMed)
(2) Antioxidant phenolic compounds from rhizomes of Polygonum paleaceum.by Wang KJ1, Zhang YJ, Yang CR.(PubMed)
(3) A new phenolic constituent and a cyanogenic glycoside from Balanophora involucrata (Balanophoraceae) by She GM1, Zhang YJ, Yang CR.(PubMed)
(4) Serum vitamin E concentration and osmotic fragility in female long-distance runners by Tomten SE1, Høstmark AT.(PubMed)
(5) [Clinical significance of measurement of plasma melatonin concentration in women withirregular menstrual cycles].[Article in Japanese] by Miyauchi F1, Nakamura Y, Numa F, Kato H, Nanjo K, Otsuka K, Sasaki T, Yonezawa M, Tsukada Y.(PubMed)
(6) [Effects of night shift on plasma concentrations of melatonin, LH, FSH and prolactin, and menstrual irregularity].[Article in Japanese]by Miyauchi F1, Nanjo K, Otsuka K.(PubMed)

Most Common Diseases of 50plus: Pulmonary vascular disease(Respiratory disease): Pulmonary edema- The Misdiagnosis

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

                           Respiratory Disease

Respiratory Disease is defined as medical conditions, affecting the breathing organ and tissues including Inflammatory lung disease, Obstructive lung diseases, Restrictive lung diseases, Respiratory tract infections, trachea, bronchi, bronchioles, alveoli, the nerves and muscles breathing, etc,.

         Pulmonary vascular disease:  Pulmonary edema


Pulmonary vascular disease is defined as a condition of blood flow to the lung’s artery is blocked suddenly due to a blood clot somewhere in the body, including pulmonary embolism, chronic thromboembolic disease, pulmonary arterial hypertension, pulmonary veno-occlusive disease, pulmonary arteriovenous malformations, pulmonary edema, etc.
                                                   
Pulmonary edema is defined as a condition of fluid accumulation in the air spaces and parenchyma of the lungs of that can lead to difficult of breathing and respiratory failure.

                             The Misdiagnosis

1. Pneumonia
Unilateral pulmonary edema can mimic as pneumonia. Clinician should be aware of differential diagnosis of pulmonary edema, otherwise it can lead to unnecessary investigation and delay in starting definitive treatment< according to the study by ths National University Hospital, National University Health System(20).
2. Acute rheumatic fever
Although the diagnostic criteria for acute rheumatic fever (ARF) are well known, a high index of suspicion is necessary in order to assure timely diagnosis and appropriate treatment. We present a case of an 8-year-old child who presented with unilateral pulmonary edema secondary to acute mitral insufficiency due to ARF. ARF should be considered in the differential diagnosis of unilateral pulmonary edema in children(21).
3. Acute mitral regurgitation
Differential diagnosis of unilateral alveolar pulmonary infiltration includes various possibilities. Acutely developing mitral insufficiency, often without any prior cardiac symptoms, may be the cause of pulmonary edema localized exclusively in the right upper lobe(22).
4. Amiodarone pneumonitis
There is a report of a case of the case of a 78-year-old woman with a history of cardiac surgery, who after 2 years of amiodarone therapy for prophylactic treatment of atrial fibrillation developed amiodarone pneumonitis mimicking an acute pulmonary edema(23).
5. Acute myocardial infarction
There is a report of a case of neurogenic pulmonary oedema (NPO) following massive left cerebral infarct, which was initially misdiagnosed as acute myocardial infarction (AMI)(24).

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

Sunday, April 10, 2016

Most Common Disease of 50plus: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Osteoarthritis: Psychological intervention in alternative medicine

Kyle J. Norton (Scholar)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed. A major restriction of joint movement range was frequent in the shoulder but uncommon in other joints(1).

Types of Musculo-Skeletal disorders in elder(2)

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia



                                                      Osteoarthritis


Osteoarthritis (OA), a form of arthritis, is defined as a condition of as a result of aging causes of wear and tear on a joint, affecting over 25 million people in the United States in alone. University of Porto Medical School indicated that one must understand the differences in prevalence and incidence estimates of osteoarthritis (OA), according to case definition, in knee, hip and hand joints(3).
The characteristics of osteoarthritis are aching pain(5), stiffness(6), or difficulty of moving the joint or joints(7). The pain usually gets worse in change of weather, at night and in the advanced diseases, the pain can occur even at rest(8). Today management of osteoarthritis (OA) focuses on pain relief and improved physical function through pharmacological, non pharmacological, and surgical treatments(4).

B. In herbal and traditional Chinese medicine perspective
B.2. Psychological intervention
Psychological intervention may be useful to reduce depression, anxiety and other symptoms in patient with RA due to associate to pain, distress and disability and reduced quality of life style in chronic pain patients, the University College London suggested(223). Dr. Matcham F and the research team at the joint study lead by King's College London said" The most consistent relationship was found between mood and fatigue, with low mood frequently associated with increased fatigue. Some evidence also highlighted the relationship between RA-related cognitions (such as RA self-efficacy) and fatigue, and non-RA-cognitions (such as goal ownership) and fatigue(224), as there is a psychological correlates of fatigue in rheumatoid arthritis.


Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offerrecommended by Kyle J. Norton

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
References

(223) Psychological therapies for the management of chronic pain (excluding headache) in adults by Williams AC1, Eccleston C, Morley S.(PubMed)
(224) Psychological correlates of fatigue in rheumatoid arthritis: a systematic review by Matcham F1, Ali S2, Hotopf M3, Chalder T4.(PubMed)

The Smoothie of Vitamin D fortified whole milk, Alpha Lipoic acid (LA) and Orange Juice for Prevention and Treatment of podocyte injury Focal segmental glomerulosclerosis

Kyle J. Norton(Scholar, Master of Nutrient, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Focal segmental glomerulosclerosis is scar tissues in the filtering unit of the kidney due to primary glomerular diseases in children and adolescents inducing edema and the loss of protein from the plasma into the urine. The syndrome may result of kidney failure when affected children and adolescents  grow into adulthood. According to Dr. Fogo AB, Focal segmental glomerulosclerosis (FSGS) has a common lesion in progressive kidney disease, and a disease characterized by marked proteinuria and podocyte injury(*).

The smoothie for prevention and treatment of podocyte injury
Yield: 2 servings (about 8 ounces each)
1 cup Vitamin D fortified whole milk
20 mg Alpha Lipoic acid (LA)
1 cup organic orange juice

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately

The finding of a natural source for treatment of podocyte injury  has been running into many obstacles, many ingredients showed initially with promising result in animal studies have not produced same potentials in large sample size and mutli centers human trials.

Recent studies back by well known institutions proposed, Vitamin D fortified whole milk, Lipoic acid (LA)  and Orange Juice may be the next generation of natural ingredients for prevention and treatment of podocyte injury due to Focal segmental glomerulosclerosis.

According to the Tokai University School of Medicine, the primary insult of podocyte injury may be short-lived. but the transmission of podocyte injury may form a vicious cycle leading to accelerated pother odocyte deterioration and glomerulosclerosis(1). Vitamin D is a fat-soluble secosteroids found in small amount in few foods, including mushroom may benefit patients of focal segmental glomerulosclerosis caused by podocyte injury(2). According to the Southeast University School of Medicine, vitamin D ameliorated podocyte injury in STZ-induced diabetic rats through down regulated over expression of TRPC6 involved the developed focal segmental glomerulosclerosis (FSGS)(3).

Lipoic acid (LA), a naturally occurring dithiol compound, has long been known as an essential cofactor for mitochondrial bioenergetic enzymes may also benefits to protect against podocyte injury. According to Anhui Provincial Hospital Affiliated to Anhui Medical University," Anti-inflammation of ALA in vivo and local kidney is implicated in the protection of glomerular Pod injury in patients with type 2 diabetes"(4).
Dr. Lin H and colleagues in the investigation of anti-inflammation of alpha-lipoic acid in type 2 diabetics, suggested that ALA exhibited protection against glomerular podocyte injury in type 2 diabetics through alleviating enhanced OS and strengthening antioxidant ability in vivo(5).

Ascorbic acid also known as vitamin C found abundantly in orange may also exhibit renal podocytes protection effects by increasing antioxidative capacity and ameliorating the renal oxidative stress(6).
According to  L. Rydygier Medical University of Bydgoszcz, vitamin C expressed potential utility of antioxidant vitamins in the protection against the development of diabetic nephropathy (7) induced podocyte injury.

The effectiveness of Vitamin D fortified whole milk, Alpha Lipoic acid (LA) and Orange Juice may serve as cornerstones of pharmaceutical target for further studies in production of a potential medication for reduced risk, complications and treatment of podocyte injurywith little or no adverse effects.

People who are at high risk of podocyte injury in Focal segmental glomerulosclerosisdue should drink no more than 4 servings daily, depending to digestive toleration.



References
(*) Causes and pathogenesis of focal segmental glomerulosclerosis by Fogo AB1.(PubMed)
(1) Podocyte injury damages other podocytes by Matsusaka T1, Sandgren E, Shintani A, Kon V, Pastan I, Fogo AB, Ichikawa I.(PubMed)
(2) The novel role of TRPC6 in vitamin D ameliorating podocyte injury in STZ-induced diabetic rats by Zhang X1, Song Z, Guo Y, Zhou M.(PubMed)
(3) REPORT A Mutation in the TRPC6 Cation Channel Causes Familial Focal Segmental Glomerulosclerosis by Michelle P. Winn1,2,*, Peter J. Conlon4, Kelvin L. Lynn5, Merry Kay Farrington1,2, Tony Creazzo3, April F. Hawkins1, Nikki Daskalakis1,2, Shu Ying Kwan2, Seth Ebersviller2, James L. Burchette5, Margaret A. Pericak-Vance1,2, David N. Howell5, Jeffery M. Vance1,2,*, Paul B. Rosenberg1(Science,AAA)
(4) Alleviation of podocyte injury: the possible pathway implicated in anti-inflammation of alpha-lipoic acid in type 2 diabetics by Bao XH1, Xu J, Chen Y, Yang CL, Ye SD.(PubMed)
(5) The alpha-lipoic acid decreases urinary podocalyxin excretion in type 2 diabetics by inhibiting oxidative stress in vivo by Lin H1, Ye S2, Xu J3, Wang W3.(PubMed)
(6) [Study on the effect and mechanism of ascorbic acid on renal podocytes in diabetes].[Article in Chinese] by Qin QJ1, Deng HC, Zhao TF, Cao WF, Liu DF, Lan LZ.(PubMed)
(7) Effect of vitamin E and vitamin C supplementation on antioxidative state and renal glomerular basement membrane thickness in diabetic kidney by Kedziora-Kornatowska K1, Szram S, Kornatowski T, Szadujkis-Szadurski L, Kedziora J, Bartosz G.(PubMed)

Most Common Diseases of 50plus: Pulmonary vascular disease(Respiratory disease): Pulmonary edema- The Diseases associated to

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

                           Respiratory Disease

Respiratory Disease is defined as medical conditions, affecting the breathing organ and tissues including Inflammatory lung disease, Obstructive lung diseases, Restrictive lung diseases, Respiratory tract infections, trachea, bronchi, bronchioles, alveoli, the nerves and muscles breathing, etc,.

         Pulmonary vascular disease:  Pulmonary edema


Pulmonary vascular disease is defined as a condition of blood flow to the lung’s artery is blocked suddenly due to a blood clot somewhere in the body, including pulmonary embolism, chronic thromboembolic disease, pulmonary arterial hypertension, pulmonary veno-occlusive disease, pulmonary arteriovenous malformations, pulmonary edema, etc.
                                                    
Pulmonary edema is defined as a condition of fluid accumulation in the air spaces and parenchyma of the lungs of that can lead to difficult of breathing and respiratory failure.


      The Diseases associated to Pulmonary edema

1. Multiple sclerosis
young woman with multiple sclerosis presented to the Emergency Department in acute respiratory failure. She was cyanotic centrally, hypertensive, and tachycardic. The chest X-ray study suggested pulmonary edema, according to the study by the Centre for Neuroscience and Neurological Research, St Vincent’s Hospital(16).
2. Primary cardiac chondroma
Primary chondroma is an exceptionally rare cardiac tumor. There is a report of a case of a patient presenting with acute pulmonary edema with the incidental echocardiographic finding of a large left atrial tumor that was histopathologically diagnosed as primary cardiac chondroma(17).
3. Atrial myxoma
Atrial myxoma is the most common primary cardiac tumor. Its clinical presentation spreads from asymptomatic incidental mass to serious life-threatening cardiovascular complications. There is a report of the case of a 44-year-old man with evening fever and worsening dyspnea in the last weeks, admitted to our hospital for acute pulmonary edema(18).
4. Pleural effusion or pneumothorax
Re-expansion pulmonary edema (RPE) is a rare but potentially fatal complication that can occur following rapid lung expansion while managing patients with pleural effusion or pneumothorax. In this case, fatal outcome occurred due to RPE in a previously healthy young adult male patient subsequent to tube thoracostomy for spontaneous pneumothorax(19),
5. Etc.

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Sources
(a) http://www.ncbi.nlm.nih.gov/pubmed/19739476
(16) http://www.ncbi.nlm.nih.gov/pubmed/22989694
(17) http://www.ncbi.nlm.nih.gov/pubmed/20889354
(18) http://www.ncbi.nlm.nih.gov/pubmed/23762077
(19) http://www.ncbi.nlm.nih.gov/pubmed/23744860