Medical Advisor Journals

Friday, April 22, 2016

The Tasty and Delicious Smoothie of Green Tea, Coffee and Grape for Reduced Risk and Treatment of Kidney Cancer (Renal Cell Carcinoma)

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for reduced risk and treatment of Kidney Cancer (Renal Cell Carcinoma)
Yield: 2 serving (about 8 ounce each)
1/2 cup grape
3/4 cup regular coffee
1 cup green tea drink (Make from 4 grams(2 tea bags) of green tea, a slice of ginger and a cup of hot water lipped for 5 minutes, and set aside for cooling to room temperature)
1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed. Add more green tea drink if needed
3. Serve immediately

Renal cell carcinoma is a type of kidney cancer caused by malignant cells of the limning of the tubules in the kidney. It tends first to spread via bloodstream and the second tumor generally found in the lung, but it may also spread to lymph nodes and other organs as well.

The finding the natural ingredients for treatment of kidney cancer (renal cell carcinoma) is considered as a dream of many scientist to replace the long term chemotherapy adverse effect of conventional medicine. Unfortunately, many compounds found effective in initial studying failed to confirm the potential in large sample size and multi centers.

Recent studies back by some prominent institutions suggested that green tea(1), coffee(4) and grape(7) may be next generation of natural ingredients for reduced risk and treatment of kidney cancer (renal cell carcinoma) due to their phytochemicals in induced apoptosis in several human cell lines.

Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Due to its commercial values and health effects, green tea now has been cultivated all over the world in suitable climate.

According to the study lead by the Agricultural University of Georgia, green tea extract GTE and corresponding nanocomposites may be effective for treatment as auxiliary agents in cancer chemotherapy(1). Dr, The incidence of renal cell carcinoma (RCC) is high in Western and Northern Europe and North America, and low in Asia. and the research team at the in the investigation of prevalence of higher incidence of renal cell carcinoma (RCC) in Western and Northern Europe and North America,in comparison of Asia counter part, insisted that the differences of the pervasiveness of renal cell carcinoma (RCC) may be due to chronic tea drinking(2).

In a cohort included 47,997 males and 66,520 females aged 40 years and older study, Dr. Washio M and colleagues at the Sapporo Medical University School of Medicine said, "consumption of black tea were associated with an increased risk of kidney cancer death(3).

Coffee drink made from roasted coffee beans is considered as one most popular beverage in Western countries may also consist the property in ameliorate risk of kidney cancer. According to the Keimyung University, its phytochemical cafestol, has been reported for its tumor cell growth inhibitory activity and anti-carcinogenic activity, including kidney cancer through modulating multiple components in apoptotic response of human renal Caki cell line(4).

Kahweol, a coffee-specific diterpene, found in the beans of Coffea arabica, also exhibited anti kidney cancer effects in down regulating pro apoptosis in Bcl-2 and anti-apoptotic regulator in c-FLIP pathways(5).
Dr. Lee JE and colleagues at the Brigham and Women's Hospital and Harvard Medical School said," Our findings provide strong evidence that neither coffee nor tea consumption increases renal cell cancer risk. Instead, greater consumption of coffee and tea may be associated with a lower risk of renal cell cancer"(6).

Resveratrol (Res) is a phytochemical in the class of Stilbenoids, found abundantly in skins and seed of grape may also be potential ingredient for treatment of kidney cancer. According to the Marshall University, resveratrol reduced risk of kidney cancer through diminished cisplatin in vitro renal toxicity and modify the development of oxidative stress(7) as well as protecting kidney damage against exposure to arsenic(9).
Dr. Yang R and colleagues at the Xinxiang Medical University said, "Res significantly inhibits the proliferation of 786-0 cells and exerts an antitumor effect by suppressing the expression of the VEGF gene in regulation of the growth of new blood vessels"(8).

The discovery of combined ingredients of green tea(1), coffee(4) and grape(7) may act as a cornerstone for induction of further investigation of the effectiveness of natural smoothie in reduced risk and treatment of kidney cancer.

People who are at increased risk of kidney cancer due to family history, gene mutation, obesity.....should drink at least one serving daily and people with kidneycancer should drink no more than 4 serving a day, depending to digestive toleration.
Change of life style and diet pattern are also recommended.

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

References

(1) Green tea, red wine and lemon extracts reduce experimental tumor growth and cancer drug toxicity by Zaletok SP1, Gulua L2, Wicker L3, Shlyakhovenko VA1, Gogol S1, Orlovsky O1, Karnaushenko OV1, Verbinenko A1, Milinevska V1, Samoylenko O1, Todor I1,Turmanidze T2.(PubMed)
(2) Risk factors for renal cell carcinoma in a Japanese population by Washio M1, Mori M, Mikami K, Miki T, Watanabe Y, Nakao M, Kubo T, Suzuki K, Ozasa K, Wakai K, Tamakoshi A.(PubMed)
(3) Risk factors for kidney cancer in a Japanese population: findings from the JACC Study by Washio M1, Mori M, Sakauchi F, Watanabe Y, Ozasa K, Hayashi K, Miki T, Nakao M, Mikami K, Ito Y, Wakai K, Tamakoshi A; JACC Study Group.(PubMed)
(4) Cafestol, a coffee-specific diterpene, induces apoptosis in renal carcinoma Caki cells through down-regulation of anti-apoptotic proteins and Akt phosphorylation by Choi MJ1, Park EJ, Oh JH, Min KJ, Yang ES, Kim YH, Lee TJ, Kim SH, Choi YH, Park JW, Kwon TK.(PubMed)
(5) The coffee diterpene kahweol sensitizes TRAIL-induced apoptosis in renal carcinoma Caki cells through down-regulation of Bcl-2 and c-FLIP by Um HJ1, Oh JH, Kim YN, Choi YH, Kim SH, Park JW, Kwon TK.(PubMed)
(6) Intakes of coffee, tea, milk, soda and juice and renal cell cancer in a pooled analysis of 13 prospective studies by Lee JE1, Hunter DJ, Spiegelman D, Adami HO, Bernstein L, van den Brandt PA, Buring JE, Cho E, English D, Folsom AR, Freudenheim JL, Gile GG,Giovannucci E, Horn-Ross PL, Leitzmann M, Marshall JR, Männistö S, McCullough ML, Miller AB, Parker AS, Pietinen P, Rodriguez C, Rohan TE, Schatzkin A,Schouten LJ, Willett WC, Wolk A, Zhang SM, Smith-Warner SA.(PubMed)
(7) Resveratrol attenuates cisplatin renal cortical cytotoxicity by modifying oxidative stress by Valentovic MA1, Ball JG2, Brown JM2, Terneus MV3, McQuade E2, Van Meter S2, Hedrick HM2, Roy AA2, Williams T2.(PubMed)
(8) Inhibitory effect of resveratrol on the expression of the VEGF gene and proliferation in renal cancer cells by Yang R1, Zhang H, Zhu L.(PubMed)
(9) Protective effect of resveratrol on arsenic trioxide-induced nephrotoxicity in rats by Zhang W1, Liu Y2, Ge M1, Jing J1, Chen Y1, Jiang H1, Yu H1, Li N1, Zhang Z1.(PubMed)

Most Common Diseases of 50plus: Pulmonary vascular disease(Respiratory disease): Pulmonary arterial hypertension - The Causes

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Respiratory Disease

Respiratory Disease is defined as medical conditions, affecting the breathing organ and tissues including Inflammatory lung disease, Obstructive lung diseases, Restrictive lung diseases, Respiratory tract infections, trachea, bronchi, bronchioles, alveoli, the nerves and muscles breathing, etc,.

Pulmonary vascular disease: Pulmonary arterial hypertension

Pulmonary vascular disease is defined as a condition of blood flow to the lung’s artery is blocked suddenly due to a blood clot somewhere in the body, including pulmonary embolism, chronic thromboembolic disease, pulmonary arterial hypertension, pulmonary veno-occlusive disease, pulmonary arteriovenous malformations, pulmonary edema, etc.

Pulmonary arterial hypertension is a subgroup of a specific subgroup of pulmonary hypertension (PH) defined as a condition of slowly progressive disorder as a result of abnormally high blood pressure in the blood vessel, including pulmonary artery, pulmonary vein, or pulmonary capillaries, that carries blood from the heart to the lungs due to narrowing in diameter of most of the very small arteries throughout the lungs of that increased resistance to blood flow, leading to right heart failure and death. Because the phrase pulmonary arterial hypertension is long and pulmonary hypertension is a bit shorter the phrase pulmonary hypertension is often used in place of pulmonary arterial hypertension(a).According to statistic, approximately over 1,000 new cases of pulmonary arterial hypertension are diagnosed each year, In the United States alone.

The Causes

1. Mutation of BMPR2 gene
Experimental and clinical studies now converge on the intersection and interactions between a genetic predisposition involving the BMPR2 signaling pathway and an impaired metabolic and chronic inflammatory state in the vessel wall(4). According to the study by the University of Cambridge School of Clinical Medicine, Heterozygous germline mutations in the gene encoding the bone morphogenetic protein type II (BMPR-II) receptor underlie the majority (>70%) of cases of familial pulmonary arterial hypertension (FPAH), and dysfunction of BMP signaling has been implicated in other forms of PAH(5).
2. Pulmonary veno-occlusive disease (PVOD)
Pulmonary veno-occlusive disease (PVOD) is a rare cause of pulmonary hypertension. So far some 200 cases have been published worldwide. Since the latest classification, agreed at a meeting in Venice in 2003, PVOD is included in the group of pulmonary arterial hypertension (PAH)(6).
3. Pulmonary endothelial injury and enhanced inflammatory response
In the study to examine the effect of pulmonary endothelial injury in BMPR2(+/-) mice, with mice with two injections of monocrotaline combined with intratracheal instillation of replication-deficient adenovirus expressing 5-lipoxygenase (MCT+Ad5LO), showed that greater endothelial injury and an enhanced inflammatory response could be the underlying causes of the sensitivity and may work in concert with BMPR2 heterozygosity to promote the development of persistent pulmonary hypertension(7).
4. The role of disturbed blood flow
According to the study by University Medical Centre Groningen-GUIDE, In this concept disturbed blood flow is seen as an important trigger in the development of vascular remodeling. For instance, in PAH associated with congenital heart disease, increased pulmonary blood flow (i.e. systemic-to-pulmonary shunt) is an essential trigger for the occurrence of neointimal lesions and PAH development. Still, questions remain about the exact role of these blood flow characteristics in disease progression(7a)
5. Certain Medication
In the late 1960s, an epidemic of primary pulmonary hypertension (PPH) occurred in Europe shortly after the introduction of aminorex fumarate, a potent anorexigen. According to the study by the McGill University Faculty of Medicinethere is a strong association between aminorex and PPH probably led to a 5-fold increase in PPH incidence, and thus a very noticeable epidemic. The association with dexfenfluramine would result in an increase in incidence of only 20%. Based on the available evidence, a repeat PPH epidemic seems unlikely(7b).

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offerrecommended by Kyle J. Norton

Sources
(a) http://pulmonaryhypertensionrn.com/ph-vs-pah/
(4) http://www.ncbi.nlm.nih.gov/pubmed/23202738
(5) http://www.ncbi.nlm.nih.gov/pubmed/16497988
(6) http://www.ncbi.nlm.nih.gov/pubmed/18814100
(7) http://www.ncbi.nlm.nih.gov/pubmed/18552156
(7a) http://www.ncbi.nlm.nih.gov/pubmed/23624788
(7b) http://www.ncbi.nlm.nih.gov/pubmed/9539893

Thursday, April 21, 2016

Most Common Disease of50plus: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Rheumatoid Arthritis: The Complications

Kyle J. Norton (Scholar)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed. A major restriction of joint movement range was frequent in the shoulder but uncommon in other joints(1).

Types of Musculo-Skeletal disorders in elder(2)
1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia

Rheumatoid Arthritis

Rheumatoid Arthritis is defined a chronic disorder as a result of inflammation, affecting mostly the flexible (synovial) joints and tissues and organs in the body. The disease affects more women than men and generally occurs after the ages of 40, causing diminished quality of life of many elders(1). According to CDC, Musculoskeletal disorders (MSDs) affects over 52 millions of adults in the US alone, including 294,000 children under age 18 with some form of arthritis or rheumatic conditions(2). Rheumatoid Arthritis can induced bone loss through elevating bone resorption without increasing bone formation(4). A cross-sectional population-based study of 1042 patients with rheumatoid arthritis showed that RA patients had an increased risk of death from various causes(4a).

The Complications

The progression of RA as of other chronic diseases in most cases induced complications constitute the expressions of other diseases, especially of the adverse effects of certain medication use.

1. Osteoporosis
The condition of gradually loss of bone mineral density due to aging has found to be associate to the complication of rheumatoid arthritis. It mat be result of bone weakening induced by the progression of the disease.
Dr Lee SG, and the research team at the Pusan National University School of Medicine, suggest, the prevalence of osteoporosis in the RA patients was 1.9 times higher than in healthy subjects. Glucocorticoid use for treatment of osteoporosis was a risk factor for generalized bone loss in female RA patients(80). In the study of Italian Study Group on Bone Mass in patient with Rheumatoid Arthritis, Dr. Insignia L and his team concluded "... osteoporosis and its dramatic complications in RA the therapeutic challenge is to preserve functional capacity using the lowest possible dosage of corticosteroids"(81).

2. Lymphoproliferative diseases
The use of Methotrexate (MTX) as a first choice of medicine for treatment of RA has been found to induced complication of MTX-related lymphoproliferative diseases (MTX-LPDs). The joint study by the Niigata Rheumatic Center suggests the cytological examinations of the synovial fluid followed by knee operation are important and effective for early diagnosis of MTX-LPD(82). The study 589 RA outpatients examined at the National Center for Global Health and Medicine in the period from January 1990 to October 2010 conducted by the Osaka University Graduate School of Medicine also supported of the above claim and expressed the concern of the therapeutic challenge is to preserve functional capacity using the lowest possible dosage of corticosteroids.(83).

3. Neurologic complications
According to Dr. Bhattacharyya S and Dr. Helfgott SM, insisted that patient with RA in many cases have found to associate to neurologic complications because of its inflammatory origins and affect on nervous system (84). Recent study of 2624 patients treated with rituximab for rheumatoid arthritis RA and other autoimmune diseases, the late-onset neutropenia was observed in 40 patients with 25 of RA of which contributed to risk of 1.3% of patients(85). Other support of above includes the study by the
The Ipswich Hospital NHS Trust, of which insisted that Late-onset neutropenia (LON) occurs infrequently after treatment with RTX, but can present with infection(86).

4. Carpal tunnel syndrome
Carpal tunnel syndrome is defined as a condition of pressure on the nerve in the wrist that supplies Carpal tunnel syndrome caused by volar dislocation of the lunate, associated with median nerve neuropathy has found in a patient with rheumatoid arthritis(87).

5. Scabies
Scabies is highly contagious skin disease caused by an infestation by the itch mite Sarcoptes is found to be another complication of medication use cause of disease(89).

6. Dry eye syndrome and Sjogren’s syndrome
According to 61 patients with rheumatoid arthritis recruited at Siriraj Hospital during March 2009-September 2010. the prevalence of secondary Sjogren's syndrome and dry eye were found with astonished rate of 28%(90). The awareness and detection of dry eye syndrome and secondary Sjogren’s syndrome in rheumatoid arthritis may has constituted the importantevaluation of their severity and proper management(91), the Mahidol University suggested.

7. Cerebral vasculitis
Cerebral vasculitis is a condition of inflammation of blood vessel wall involving the nervous system.
The diseases also share some characteristics with RA such as elevated levels of white blood cells, erythrocyte sedimentation rate, C-reactive protein, IgG-rheumatoid factor and immune complex(92). Dr. Ohno T and the reaserch team at the Ohtsu Red Cross Hospital reported that methotrexate is found effectively in treatment of long lasting rheumatoid cerebral vasculitis(93).

8. Other complications
According to 10 relevant studies out of 2326 bibliographic citations found by the University of Palermo, complication associate to RA, include ericardial effusion (OR 10.7; 95% CI 5.0-23.0), valvular nodules (OR 12.5; 95% CI 2.8-55.4), tricuspidal valve insufficiency (OR 5.3; 95% CI 2.4-11.6), aortic valve stenosis (OR 5.2; 95% CI 1.1-24.1), mitral valve insufficiency (OR 3.4; 95% CI 1.7-6.7), aortic valve insufficiency (OR 1.7; 95% CI 1.0-2.7), combined valvular alterations (OR 4.3; 95% CI 2.3-8.0), mitral valve thickening and/or calcification (OR 5.0; 95% CI 2.0-12.7), aortic valve thickening and/or calcification (OR 4.4; 95% CI 1.1-17.4), valvular thickening and/or calcification (OR 4.8; 95% CI 2.2-10.5), and mitral valve prolapse (OR 2.2; 95% CI 1.2-4.0)(88).

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer recommended by Kyle J. Norton

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

References
(1) 8 Areas of Age-Related Change(NIH)
(2) Arthritis-Related Statistics(CDC)
(3) Valgus deformities of the feet and characteristics of gait in patients who have rheumatoid arthritis by Keenan MA1, Peabody TD, Gronley JK, Perry J.(PubMed)
(4) Serum Sclerostin Level Among Egyptian Rheumatoid Arthritis Patients: Relation to Disease Activity ,Bone Mineral Density and Radiological Grading by Mehaney DA, Eissa M, Anwar S, El-Din SF(PubMed)
(4a) Death rates and causes of death in patients with rheumatoid arthritis: a population-based study by Sihvonen S1, Korpela M, Laippala P, Mustonen J, Pasternack A(PubMed)
(81) A multicenter cross sectional study on bone mineral density in rheumatoid arthritis. Italian Study Group on Bone Mass in Rheumatoid Arthritis by Sinigaglia L1, Nervetti A, Mela Q, Bianchi G, Del Puente A, Di Munno O, Frediani B, Cantatore F, Pellerito R, Bartolone S, La Montagna G, Adami S.(PubMed)
(82) A case of rheumatoid arthritis with methotrexate related lymphoproliferative diseases of the knee by Abe A1, Wakaki K2, Ishikawa H1, Ito S1, Murasawa A1.(PubMed)
(83) Clinical characteristics and incidence of methotrexate-related lymphoproliferative disorders of patients withrheumatoid arthritis by Yoshida Y1, Takahashi Y, Yamashita H, Kano T, Kaneko H, Mimori A(PubMed)
(84) Neurologic complications of systemic lupus erythematosus, sjögren syndrome, and rheumatoid arthritis by Bhattacharyya S1, Helfgott SM2.(PubMed)
(85) Late-onset neutropenia after treatment with rituximab for rheumatoid arthritis and other autoimmune diseases: data from the AutoImmunity and Rituximab registry by Salmon JH1, Cacoub P2, Combe B3, Sibilia J4, Pallot-Prades B5, Fain O6, Cantagrel A7, Dougados M8, Andres E9, Meyer O10, Carli P11, Pertuiset E12, Pane I13, Maurier F14, Ravaud P13, Mariette X15, Gottenberg JE16.(PubMed)
(86) Late-onset neutropenia in patients with rheumatoid arthritis after treatment with rituximab by Abdulkader R1, Dharmapalaiah C, Rose G, Shand LM, Clunie GP, Watts RA.(PubMed)
(87) Carpal tunnel syndrome caused by volar dislocation of the lunate in a patient with rheumatoid arthritis by Oka Y1, Tokunaga D, Fujiwara H, Hojo T, Takatori R, Kubo T.(PubMed)
(88) Heart involvement in rheumatoid arthritis: systematic review and meta-analysis by Corrao S1, Messina S, Pistone G, Calvo L, Scaglione R, Licata G.(PubMed)

(89) Scabies in a Patient with Rheumatoid Arthritis Treated with Adalimumab - A Case Report by Marković I, Pukšić S, Gudelj Gračanin A, Čulo MI, Mitrović J, Morović-Vergles J1.(PubMed)
(90) Prevalence of dry eye syndrome and Sjogren's syndrome in patients with rheumatoid arthritis by Kosrirukvongs P1, Ngowyutagon P, Pusuwan P, Koolvisoot A, Nilganuwong S.(PubMed)
(91) A study of the prevalence of sicca symptoms and secondary Sjögren's syndrome in patients with rheumatoid arthritis, and its association to disease activity and treatment profile by Haga HJ1, Naderi Y, Moreno AM, Peen E.(PubMed)
(92) [Multiple cerebral infarction associated with cerebral vasculitis in rheumatoid arthritis].[Article in Japanese]by Ohta K1, Tanaka M, Funaki M, Sakauchi M, Suzuki N.(PubMed)
(93) Recovery from rheumatoid cerebral vasculitis by low-dose methotrexate by Ohno T1, Matsuda I, Furukawa H, Kanoh T.(PubMed)
(94) Evidence-based Recommendations for the Management of Comorbidities in Rheumatoid Arthritis, Psoriasis, and Psoriatic Arthritis: Expert Opinion of the Canadian Dermatology-Rheumatology Comorbidity Initiative by Roubille C1, Richer V1, Starnino T1, McCourt C1, McFarlane A1, Fleming P1, Siu S1, Kraft J1, Lynde C1, Pope J1, Gulliver W1, Keeling S1, Dutz J1, Bessette L1,Bissonnette R1, Haraoui B1.(PubMed)

The Best Smoothie of Flax seed, Cabbage Leaf, Vitex agnus(Chasteberry) extract and avocado for Prevention and Treatment of Breast engorgement

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The curable smoothie for reduced risk and treatment of Breast engorgement
1/2 cup flaxseed
6 mg Vitex agnus extract
1 1/2 cooked cabbage leaf
1 cup organic avocado juice

The finding of a natural source for reduced risk and treatment of Breast engorgement has encountered many obstacles, many ingredients showed initially the promising result in animal studies have not produced same potentials in either large sample size and mutli centers human trials.

Scientists in some well known institutions may have found the therapeutic and potential ingredients from natural sources(such as Ginger, Alfalfa Sprout and Orange) for reduced risk and treatment of Breast engorgement.

Breast engorgement is the painful swelling with overfilling of the breasts with milk or extra blood and lymph fluids in the breast tissue.
Applying cabbage leaf may benefits for women with breast engorgement(2) on relieving discomfort and decreasing tissue hardness, according to the Northern Territory University in Darwin(1).

Dr. Lim AR and colleagues led by the Korea Institute of Oriental Medicine Daejeon, suggested that cabbage compression early breast care (CCEBC) sginificantly effect on breast pain, breasthardness with general nursing breast care (GNBC) in primiparous women after cesarean birth(3).

Furthermore, a randomized, controlled trial conducted to evaluate the effect of cabbage leaves on mothers' perceptions of breast engorgement said,"The experimental group tended to report less breast engorgement, but this trend was not statistically significant. At six weeks, women who received the cabbage leafapplication were more likely to be breastfeeding exclusively,"(4).

Flaxseed oil, an extracted from the seeds of the flax plant (Linum usitatissimum) contained both omega-3 and omega-6 fatty acids may be effective in reduced breast pain for women with Breast engorgement. According to the joint study led by the Tabriz University of Medical Sciences, in randomized controlled trial on 159 women, Flaxseed are effective in short-term period in decreasing cyclical mastalgia(5).

The Memorial Sloan-Kettering Cancer Center study in review the effectiveness of flaxseed in of the literature of data bases suggetsed that the seed may benefit women with cyclic mastalgia (breast pain) due to the efficacy of alpha-linoleic acid(6).

Dr. Rosolowich V and colleagues at the Winnipeg Regional Health Authority, said, "Flaxseedshould be considered as a first-line treatment for cyclical mastalgia"(7).

Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belongings to the family Lamiaceae, native to the Mediterranean region, used in herbal medicine for thousands of year as anaphrodisiac herb and is considered as Queen herb in treating menstrual problems. The herbal extract has found effectively in reduced pain in women with Breast engorgement(5).

According to the Royal Melbourne Institute of Technology-University, the popular herbal treatment, Vitex agnus-castus L. showed to reduce serum prolactin levels and ameliorate cyclic mastalgia in comparable to bromocriptine(8).

Dr. Halaska M and colleafues at the I. gynek.-porod. klinika 1. said, " Intensity of breast pain diminished quicker with .Vitex agnus castus (VACS) extract group. The tolerability was satisfactory. We found VACS to be useful in the treatment of cyclical breast pain in women"(9).

Vitamin E, a fat soluble viatmin found abundantly in avocado may also be used as natural supplemental agents for treatment of cyclic mastalgia, according to the study led by Hamadan University of Medical Sciences(10).

The evaluation the effectiveness of vitamin E, evening primrose oil (EPO), and the combination of vitamin E and EPO for pain control in women with cyclical mastalgiam conducted by the Mayo Clinic said,"Daily doses of 1,200 IU vitamin E, 3,000 mg EPO, or vitamin E and EPO in combination at these same dosages taken for six months may decrease the severity of cyclical mastalgia"(10).

The effectiveness of Flax seed, Cabbage Leaf, Vitex agnus extract and avocado may serve as cornerstones of pharmaceutical target for further studies in production of a potential medication for for Reduced Risk and treatment of Breast engorgement with little or no adverse effects.

Women who are at increased risk of Breast engorgement due to family history,.....may drink at least one serving daily and women with Breast engorgement may drink as much as they can, depending to the digestive toleration.
Topical administration of cabbage leaf are recommended.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer recommended by Kyle J. Norton

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

References
(1) Effects of cabbage leaf extract on breast engorgement by Roberts KL1, Reiter M, Schuster D.(PubMed)
(2) Cabbage leaves vs hot and cold compresses in the treatment of breast engorgement by Arora S1, Vatsa M, Dadhwal V.(PubMed)
(3) Cabbage compression early breast care on breast engorgement in primiparous women after cesarean birth: a controlled clinical trial by Lim AR1, Song JA1, Hur MH1, Lee MK1, Lee MS2.(PubMed)
(4) Do cabbage leaves prevent breast engorgement? A randomized, controlled study by Nikodem VC, Danziger D, Gebka N, Gulmezoglu AM, Hofmeyr GJ.(PubMed)
(5) Effects of Vitex agnus and Flaxseed on cyclic mastalgia: A randomized controlled trial by Mirghafourvand M1, Mohammad-Alizadeh-Charandabi S2, Ahmadpour P3, Javadzadeh Y4.(PubMed)
(6) Flax and flaxseed oil (Linum usitatissimum): a review by the Natural Standard Research Collaboration by Basch E1, Bent S, Collins J, Dacey C, Hammerness P, Harrison M, Smith M, Szapary P, Ulbricht C, Vora M, Weissner W; Natural Standard Resource Collaboration(PubMed)
(7) Mastalgia.[Article in English, French]by Rosolowich V1, Saettler E, Szuck B, Lea RH, Levesque P, Weisberg F, Graham J, McLeod L, Rosolowich V; Society of Obstetricians and Gynecologists of Canada (SOGC).(PubMed)
(8) Vitex agnus-castus extracts for female reproductive disorders: a systematic review of clinical trials by van Die MD1, Burger HG, Teede HJ, Bone KM.(PubMed)
(9) [Treatment of cyclical mastodynia using an extract of Vitex agnus castus: results of a double-blind comparison with a placebo].[Article in Czech]by Halaska M1, Raus K, Bĕles P, Martan A, Paithner KG.(PubMed)
(10) Vitamin E and evening primrose oil for management of cyclical mastalgia: a randomized pilot study by Pruthi S1, Wahner-Roedler DL, Torkelson CJ, Cha SS, Thicke LS, Hazelton JH, Bauer BA.(PubMed)

Most Common Diseases of 50plus: Pulmonary vascular disease(Respiratory disease): Pulmonary arterial hypertension – The Symptoms

The Symptoms

1. Depressive disorder
In the study to screen Consecutive outpatients with PAH of a A group of 100 patients (88% women, 50% with idiopathic PAH) (idiopathic; or associated with scleroderma, congenital heart disease, or anorexiant use) seen in two university PAH clinics, showed that 5% of subjects had symptoms suggestive of major depressive disorder; 40% had mild-to-moderate depressive symptoms; and 45% had no-to-minimal depressive symptoms(1).
2. Other symptoms
In the study to use cluster analysis to describe the symptom profile in PAH and differences in the health outcomes of health status, health-related quality of life (HRQoL) and psychological states in the cluster groups, by University of Pennsylvania, School of Nursing, found that of the 151 participants, the mean age was 53.5 ± 15.1 with the majority female (n = 128, 85%). Fifty-eight (41%) were disabled and 67 (44%) were Functional Class IV. The most prevalent symptoms were shortness of breath with exertion (n = 149, 99%) and fatigue (n = 144, 93%). Three clusters emerged: Cluster 1 diffuse symptoms (n = 93), Cluster 2 severe cardiopulmonary symptoms (n = 32) and Cluster 3 moderate cardiopulmonary symptoms (n = 26). Overall, on the SF-36 the participants had poor general health, reduced physical function, role physical, vitality, and a low composite score for physical health. On the POMS the sample had limited vigor and increased fatigue. Other study showed that
The most common symptom of PH is breathlessness on exertion. Syncope may be the presenting symptom especially in children. Other PH symptoms include: angina pectoris, palpitations, dry cough, exertional nausea and vomiting(3).

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

Sources
(a) http://pulmonaryhypertensionrn.com/ph-vs-pah/
(1) http://www.ncbi.nlm.nih.gov/pubmed/20587763
(2) http://www.ncbi.nlm.nih.gov/pubmed/22357779
(3) http://www.ncbi.nlm.nih.gov/pubmed/23477017

Most Common Disease of50plus: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Rheumatoid Arthritis: Misdiagnosis and Delay diagnosis

The Smoothie of Ginger, Alfalfa Sprout Juice and Orange Juice for Prevention and Treatment of Menorrhagia

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The curable smoothie for reduced risk and treatment of Menorrhagia
1 cup of organic orange juice
1 large slice ginger root
1 cup alfalfa sprout juice

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed. Add more green tea drink if needed
3. Serve immediately

The finding of a natural source for reduced risk and treatment of Menorrhagia has encountered many obstacles, many ingredients showed initially the promising result in animal studies have not produced same potentials in either large sample size and mutli centers human trials.

Scientists in some well known institutions may have found the therapeutic and potential ingredients from natural sources(such as Ginger, Alfalfa Sprout and Orange) for reduced risk and treatment of Menorrhagia

Menorrhagia is a menstrual condition of abnormal heavier vaginal bleeding. According to the bioflavonoids and vitamin C(1) may offer the potential treatment by preventing the breaking of vaginal capillaries inducing heavy bleeding(2).

Ginger (Zingiber officinale) or ginger root is the genus Zingiber, belongings to the family Zingiberaceae, native to Tamil. According to the Iran University of Medical Sciences, application of ginger in 92 young women who experienced HMB significantly reduced the level of menstrual blood loss during the three intervention cycles in ginger-receiving group(3).

Phytoestrogen found in alfalfa sprout juice expressed both estrogenic and anti estrogenic effect may also benefit women with heavy menstrual bleeding due to hormone imbalance(4). According to Fatih Yildiz, as in functional foods, intake of phytoestrogen may contribute to the deduction of heavy bleeding due to estrogen deficiency(5)(6).

Vitamin C, a water soluble vitamin found abundantly in orange may also be used to treat heavy
bleeding due to weaken uterine capillaries due to aging or vitamin C deficiency(1)(7). According to
the Burn Center-BG Trauma Center Ludwigshafen, high dose of vitamin C significantly reduced capillary leakage after burn plasma transfer in animal model(7).
In fact, the effectiveness of vitamin C in reduced risk of heavy bleeding may be due to its effect in wound healing of the breaking off of endometrial lining during menstruation(8)(9).

The effectiveness of Ginger, Alfalfa Sprout Juice and Orange Juice may serve as cornerstones of pharmaceutical target for further studies in production of a potential medication for for Reduced Risk and treatment of Menorrhagia with little or no adverse effects.

Women who are at increased risk of Menorrhagia due to family history, aging,.....may drink at least one serving daily and women with Menorrhagia may drink as much as they can, depending to the digestive toleration.
Life style and dietary patter change are recommended.

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

References
(1) Functional menorrhagia: treatment with bioflavonoids and vitamin C. by COHEN JD, RUBIN HW.(PubMed)
(2) Capillary strength of women with menorrhagia by ALAN C, CLEMETSON B, BLAIR LM.(PubMed)
(3) Effect of ginger (Zingiber officinale) on heavy menstrual bleeding: a placebo-controlled, randomized clinical trial by Kashefi F1, Khajehei M, Alavinia M, Golmakani E, Asili J.(PubMed)
(4) Phytoestrogen content and estrogenic effect of legume fodder by Saloniemi H1, Wähälä K, Nykänen-Kurki P, Kallela K, Saastamoinen I.(PubMed)
(5) Phytoestrogens In Functional Foodsedited by Fatih Yildiz
(6) The New Harvard Guide to Women's Health By Karen J. Carlson, Stephanie A. Eisenstat, Terra Diane Ziporyn
(7) High-dose vitamin C treatment reduces capillary leakage after burn plasma transfer in rats by Kremer T1, Harenberg P, Hernekamp F, Riedel K, Gebhardt MM, Germann G, Heitmann C, Walther A.(PubMed)
(8) Vitamin C and human wound healing by Ringsdorf WM Jr, Cheraskin E.(PubMed)
(9) Efficacy of vitamin supplementation in situations with wound healing disorders: results from clinical intervention studies by6 Ellinger S1, Stehle P.(PubMed)