Medical Advisor Journals

Thursday, May 26, 2016

Most Common Diseases of 50plus: Diabetes(The Recipes) --- Olive and Lemon Juice Vinaigrette

Most Common Disease of 50plus: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Polymyalgia Arthritis (Rheumatica): Misdiagnosis and delay diagnosis

Kyle J. Norton (Scholar)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed. A major restriction of joint movement range was frequent in the shoulder but uncommon in other joints(1).

Types of Musculo-Skeletal disorders in elder(2)
1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalgia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia

Polymyalgia Arthritis (Rheumatica)

Polymalgia Arthritis is defined as a condition a common inflammatory rheumatic disease which causes pain, stiffness and tenderness in large muscles, including muscles shoulders and pelvic girdle as a result of the presence of a synovitis in proximal joints and periarticular structures.

The Misdiagnosis and delay diagnosis

Polymyalgia rheumatica (PMR) is a very painful inflammatory disease, affecting the shoulder region and the pelvic girdle region in people over 50 year of age. But according to Dr, Talke M and Dr. Schmidt WA. said" the misdiganosis is common, .....taking a structured medical history and performing a thorough clinical examination are crucial" and "patient with elevated erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) levels should be investigated particularly in patients who present with new onset bilateral shoulder pain and pronounced general impairment of movement"(84).
1. Spondyloarthropathy
Late onset of pondyloarthropathy, a disease characterized as a joint disease of the vertebral column is often misdiagnosed as Polymyalgia Rheumatica(PMR). According to the centre hospitalier d'Aulnay-sous-Bois, eight patients with spondyloarthropathy with poor response to corticosteroids and multiple flares,were misdiagnosed as PMR(85). The Gaziantep University study also showed the similarities of pondyloarthropathy and PMR in a patient of 50 year of age(86).

2. Osteoarthritis of the shoulders
Osteoarthritis of the shoulders in some case may be wrongly diagnosis as PMR due to the relapse of the symptoms of similarity in both diseases(87), According to the Istituto di Ricovero e Cura a Carattere Scientifico, patients with PMR and pain in the shoulder is alo hound in 2 patients with spinal osteoarthritis(88).

3. Calcifying tendinitis of the rotator cuff
Calcifying tendinitis is disease characterized by a building-up of calcium in the rotator cuff (calcific deposit) in some case may be misdianosed as PMR(87).

4. Bursitis
Bursitis is an inflammation of a bursa of the knee, elbow or shoulder in some cases may be misdiagnosed as PMR(87). According to Asklepios Clinic, in the investigation of 54 consecutive patients with recent-onset PMR, over 30% with Subdeltoid bursitis(89).

5. Rheumatoid arthritis
Rheumatoid arthritis, a chronic inflammatory rheumatic diseases, found most often in the people age of 50 and over may be misdiagnosed as PMR(87). According to the Università di Pavia, the percentage of patient diagnosed with RA and PMR often change in first and during follow up diagnosis(90) due to like onset of patient with PMR.

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

REFERENCES
(81) [Thrombocytosis in progressive generalized sclerosis (scleroderma) and in other rheumatic diseases].[Article in German] by Valentini G, Chianese U, Tirri G, Giordano M.(PubMed)
(82) Early recognition improves prognosis in elderly onset RA. by Negoescu A, Ostör AJ.(PubMed)
(83) Giant cell arteritis and polymyalgia rheumatica. Review for the otolaryngologist by Ferguson BJ, Allen NB, Farmer JC Jr.(PubMed)
(84) [Polymyalgia rheumatica in daily routine practice].[Article in German] by Talke M1, Schmidt WA.(PubMed)

(85) [Late onset spondyloarthropathy misdiagnosed as polymyalgia rheumatica].[Article in French] by Kouassi Djaha JM1, Jenvrin C, Dupont MP, Steiner J, de Bandt M.(PubMed)
(86) Late onset spondyloarthropathy mimicking polymyalgia rheumatica by Aydeniz A1, Altındağ O, Oğüt E, Gürsoy S.(PubMed)
(87) [Polymyalgia rheumatica in daily routine practice].[Article in German] by Talke M1, Schmidt WA(PubMed)
(88) Lumbar interspinous bursitis in active polymyalgia rheumatica by Salvarani C1, Barozzi L, Boiardi L, Pipitone N, Bajocchi GL, Macchioni PL, Catanoso M, Pazzola G, Valentino M, De Luca C, Hunder GG.(PubMed)
(89) Joint involvement in patients with early polymyalgia rheumatica using high-resolution ultrasound and its contribution to the EULAR/ACR 2012 classification criteria for polymyalgia rheumatica by Weigand S1, Ehrenstein B, Fleck M, Hartung W.(PubMed)
(90) Presenting features of polymyalgia rheumatica (PMR) and rheumatoid arthritis with PMR-like onset: a prospective study by Caporali R1, Montecucco C, Epis O, Bobbio-Pallavicini F, Maio T, Cimmino MA.(PubMed)

The Smoothie of Avocado, Banana, Yogurt, Plain Chocolate and Vitamin D fortified low fat milk for Treatment of Gitelman syndrome

Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.

Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post

Nominated for shorty award over last 4 years

Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for treatment of Gitelman syndrome

Yield: 2 servings (about 8 ounces each)

1/2 cup avocado
1/2 cup banana
1/4 cup yogurt
1/4 plain chocolate
1 cup vitamin D fortified low fat milk

1. Place all ingredients in a blender and puree about 1 minute

2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.

3. Serve immediately

The finding of a natural source for treatment of Gitelman syndrome has been running into many obstacles, many ingredients showed initially with promising result in animal studies have not produced same potentials in large sample size and mutli centers human trials.

Gitelman syndrome is an autosomal recessive distal renal tubular disorder caused by defective sodium chloride transporters inducing hypokalaemic metabolic alkalosis, hypomagnesaemia and hypocalciuria(1). In other words it is a kidney disease caused by an imbalance of ions of potassium, magnesium, and calcium. Recent study lead by the University of Padova suggested that patients with Gitelman syndrome are associated to increase existence of reactive oxygen species (ROS) and oxidative stress of that status could offer chances for new therapeutic targets in disease characterized by high levels of reactive oxygen species(2).
According to the Royal Liverpool and Broadgreen University Hospitals NHS Trust. treatment of Gitelman syndrome may include oral potassium supplement, weekly intravenous potassium and magnesium infusion, correction of vitamin D level and the offering of appropriate dietary advice(3).

Avocado and banana rich in potassium and yogurt and plain chocolate may be used a daily dietary sources for treatment of Gitelman syndrome in replacement of oral potassium and magnesium supplements.

In take of vitamin D fortified low fat milk should also be necessary for increased absorption of calcium according to study. Furthermore dietary change plays an important role to maintain right levels of potassium, magnesium, and calcium in the blood for prevention of the syndrome induced complications.

The combination of Avocado, Banana, Yogurt, Plain Chocolate and Vitamin D fortified low fat milk smoothie may hold a key in further studies in production of an effective natural ingredients for treatment of Gitelman syndrome without inducing adverse effects.
People with Gitelman syndrome should drink as much as they can depending to the digestive toleration.

Dietary change with lot of vegetables, fruits and deep sea fish will be helpful in reduced risk of muti nutrients deficiency case of syndrome exaggeration.

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
References
(1) Management of a severe case of Gitelman syndrome with poor response to standard treatment b Koudsi L1, Nikolova S1, Mishra V1.(PubMed)
(2) Bartter/Gitelman syndromes as a model to study systemic oxidative stress in humans by Maiolino G1, Azzolini M1, Rossi GP1, Davis PA2, Calò LA3(PubMed)
(3) Management of a severe case of Gitelman syndrome with poor response to standard treatment by Koudsi L1, Nikolova S1, Mishra V1.(PubMed)

Herbal therapy: Popular Herbal Cranberry

Popular Herbal Cranberry

Cranberry is a evergreen dwarf shrubs, genus Vaccinium, belonging to the familyEricaceae, native to Northern America and Southern Asia. Because of health benefits, it has been cultivated in some parts of the world forcommercial profits and used in traditional and herbal medicine to treat wounds,
urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.

Health Benefits
1. Infectious disease
In the investigation of cranberry Proanthocyanin constituents and it effects in infectious diseases found that mouthwash supplemented isolated cranberryderivative reduced significantly the caryogenic mutans streptococci, according to the study of "Cranberry components for the therapy of infectious disease" by Shmuely H, Ofek I, Weiss EI, Rones Z, Houri-Haddad Y.(1)

2. Urinary tract infection
In the observation of antiadherence properties in cranberry and it effects in preventing infection, found that it prevents fimbriated Escherichia coli from adhering to uroepithelial cells in the urinary tract, according "Cranberry juice andurinary tract infection" by Raz R, Chazan B, Dan M.(2)

3. Antibiotics
In the evaluation of Cranberry juice consumption taking along with low-dose oral antibiotics for prophylaxis for recurrent urinary tract infection (UTI) found that concurrent use of cranberry juice has no significant effect on the extent of oral absorption or the renal clearance of amoxicillin and cefaclor, but delays in the absorption of amoxicillin and cefaclor were observed, according to the study of"Effects of cranberry juice on pharmacokinetics of beta-lactam antibiotics following oral administration" by Li M, Andrew MA, Wang J, Salinger DH, Vicini P, Grady RW, Phillips B, Shen DD, Anderson GD.(3)

4. Antibacterial effects
In the examination of daily cranberry juice cocktail to those of placebo during pregnancy and it effects on asymptomatic bacteriuria and symptomatic urinary tract infections found that 27 urinary tract infections in 18 subjects in this cohort, with 6 in 4 group A subjects, 10 in 7 group B subjects and 11 in 7 group C subjects (p = 0.71). There was a 57% and 41% reduction in the frequency of asymptomatic bacteriuria and all urinary tract infections, respectively, according to the study "Daily cranberry juice for the prevention of asymptomatic bacteriuria in pregnancy: a randomized, controlled pilot study" by Wing DA, Rumney PJ, Preslicka CW, Chung JH.(4)

5. Pathogenic microorganisms
In the determination of cranberry juice and its inhibitory effects of pathogenic microorganisms found that S. aureus was more susceptible to cranberry juiceinhibition than the other microorganisms. L. monocytogenes was the most resistant to the inhibitory action of cranberry juice, showing a significant difference from the inhibition of P. aeruginosa, uropathogenic E. coli, Salmonella spp., and S. aureus, according to the study of "In vitro inhibitory effect of cranberry (Vacciniummacrocarpom Ait.) juice on pathogenic microorganisms" by Magariños HL, Sahr C, Selaive SD, Costa ME, Figuerola FE, Pizarro OA(5)

6. Antioxidant effects
In the determination of Cranberry products and especially cranberry juice (CJ) and its phenolic antioxidants found that the control High fructose corn syrup (HFCS) caused a slight decrease in plasma antioxidant capacity at all time points and thus an oxidative stress in spite of the presence of ascorbate. CJ produced an increase in plasma antioxidant capacity that was significantly greater than control HFCS at all time points, according to the study of "Cranberries and cranberry products: powerful in vitro, ex vivo, and in vivo sources of antioxidants" by Vinson JA, Bose P, Proch J, Al Kharrat H, Samman N.(6)

7. Drug interaction
In the evaluation of cranbeery juice and its interaction on warfarin found that large volumes of cranberry juice destabilize warfarin therapy. Small amounts of juice are not expected to cause such an interaction, according to the study of "Interaction between warfarin and cranberry juice" by Aston JL, Lodolce AE, Shapiro NL.(7)

8. PH levels
In the research of cranberry juice and it effect on urinary pH, found that there were significant (.01 level) differences in mean urinary pH between each control group and its corresponding experimental group, according to the study of "Effect ofcranberry juice on urinary pH" by

Kinney AB, Blount M.(8)

9. Lipoprotein oxidation
In the investigation of Cranberry juice consumptionand it effects on cholesterol found that when LDL oxidation took place in the presence of diluted cranberryextracts, the formation of thiobarbituric acid reactive substances (TBARS) and LDL electrophoretic mobility were reduced. LDL electrophoretic migration was also reduced when the cranberry extract had a pH of 7.00 prior to dilution. according to the study of "Cranberry extract inhibits low density lipoprotein oxidation" byWilson T, Porcari JP, Harbin D.(9)

10. Skin conditions
In research of Cranberry juice and it effects on skin condition of urostomy patients found that while drinking cranberry juice did not appear to acidify the urine as expected, improvements were still seen in the skin conditions of the study participants, suggesting that drinking cranberry juice does positively impact the incidence of skin complications for these patients, according to the study of "Cranberry juice and its impact on peri-stomal skin conditions for urostomy patients" by Tsukada K, Tokunaga K, Iwama T, Mishima Y, Tazawa K, Fujimaki M.(10)

11. Etc.

Phytochemicals In Foods: The effects of Sinigrin

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sinigrin is a phytochemical glucosinolate, belongs to the family of glucosides found abundantly in Brussels sprouts, broccoli, the seeds of black mustard, etc.

Health Benefits
1. Bladder cancer
In the design of testing the hypothesis of AITC-containing cruciferous vegetables also inhibit bladder cancer development, indicated that Comparison between hydrated MSP-1 and pure sinigrin with added myrosinase suggested that the anticancer effect of MSP-1 was derived principally, if not entirely, from the AITC generated from sinigrin. In an orthotopic rat bladder cancer model, oral MSP-1 at 71.5 mg/kg (sinigrin dose of 9 μmol/kg) inhibited bladder cancer growth by 34.5% (P < 0.05) and blocked muscle invasion by 100%, according to "Allyl isothiocyanate-rich mustard seed powder inhibits bladder cancer growth and muscle invasion" by Bhattacharya A, Li Y, Wade KL, Paonessa JD, Fahey JW, Zhang Y.(1)

2. Multidirectional time-dependent effect
In a research of nutritional significance of parent glucosinolate sinigrin 50 μmol/kg b. w./day and its degradation product allyl isothiocyanate 25 μmol/kg b. w./day and 50 μmol/kg b. w./day was studied by the evaluation of their influence on some parameters of carbohydrate and lipid metabolism in an animal rat model in vivo after their single (4 h) and 2 weeks oral administration, showed that the effect of SIN and AITC is multidirectional, indicating its impact on many organs like liver as well as pancreas, intestine in vivo action and rat adipocytes in vitro. Whilst consumption of cruciferous vegetables at levels currently considered "normal" seems to be beneficial to human health, this data suggest that any large increase in intake could conceivably lead to undesirable effect, according to "Multidirectional time-dependent effect of sinigrin and allyl isothiocyanate on metabolic parameters in rats" by Okulicz M.(2)

3. Postprandial hypertriglyceridemia
In the examination of the bioactivity of Yamato-mana (Brassica rapa L. Oleifera Group) constituent glucosinolates with 3-butenyl glucosinolate (gluconapin) decreased the plasma triglyceride gain induced by corn oil administration to mice, indicated that phenethyl glucosinolate (gluconasturtiin) had little effect. 2-Propenyl glucosinolate (sinigrin) also reduced the plasma triglyceride level, which suggests that alkenyl glucosinolates might be promising agents to prevent postprandial hypertriglyceridemia, according to "Suppressive effect of Yamato-mana (Brassica rapa L. Oleifera Group) constituent 3-butenyl glucosinolate (gluconapin) on postprandial hypertriglyceridemia in mice" by Washida K, Miyata M, Koyama T, Yazawa K, Nomoto K.(3)

4. Antimicrobial effects
In the investigation of Allyl isothiocyanate (AIT) derived from the glucosinolatesinigrin found in plants of the family Brassicaceae and its antimicrobial agent against a variety of organisms, including foodborne pathogens such as Escherichia coli O157:H7, found that it can be postulated that: 1) AIT is a more effective antimicrobial at low pH values and its degradation reduces this activity; 2) decomposition products in water might not participate in the antimicrobial action of AIT; and 3) AIT seems to have a multi-targeted mechanism of action, perhaps inhibiting several metabolic pathways and damaging cellular structures, according to "Enzymatic inhibition by allyl isothiocyanate and factors affecting its antimicrobial action against Escherichia coli O157:H7" by Luciano FB, Holley RA.(4)

5. Liver cancer
In the determination of the inhibitory effects of AITC and its NAC conjugate on cell proliferation, the expression of matrix metalloproteinases (MMPs), adhesion, invasion, and migration in SK-Hep 1 human hepatoma cells, found that AITC and NAC-AITC suppress SK-Hep 1 cell proliferation in a dose-dependent manner; by 25% and 30% for 10 microM AITC and 10 microM NAC-AITC, respectively. The influence of AITC and NAC-AITC on the gene expression of MMPs and tissue inhibitors of metalloproteinase (TIMPs). Gelatin zymography also revealed a significant downregulation of MMP-2/-9 expression in SK-Hep1 cells treated with 0.1-5 microM AITC and NAC-AITC compared with controls. Reverse transcriptase polymerase chain reaction revealed dose-dependent decreases in MMP-2/-9 messenger RNA levels in both AITC-treated and NAC-AITC-treated cells, according to "Allyl isothiocyanate and its N-acetylcysteine conjugate suppress metastasis via inhibition of invasion, migration, and matrix metalloproteinase-2/-9 activities in SK-Hep 1 human hepatoma cells" by Hwang ES, Lee HJ.(5)

6. Detoxication enzymes
In the examination of the ability of allyl nitrile, a hydrolysis product of the glucosinolate sinigrin, to increase tissue levels of the phase 2 detoxication enzymes glutathione S-transferase and quinone reductase and GSH in a variety of mouse tissues, found that show that allyl nitrile displays its maximum potency in the stomach and lungs, which is of interest in light of epidemiological studies demonstrating an inverse association between crucifer intake and the incidence of stomach and lung cancers, according to "Induction of detoxication enzymes in mice by naturally occurring allyl nitrile" by Tanii H, Higashi T, Nishimura F, Higuchi Y, Saijoh K.(6)

7. Anti-SARS coronavirus 3C-like protease effects
In the study, Isatis indigotica root extract, five major compounds of I. indigotica root, and seven plant-derived phenolic compounds were tested for anti-SARS-CoV 3CLpro effects using cell-free and cell-based cleavage assays, found that Cleavage assays with the 3CLpro demonstrated that IC50 values were in micromolar ranges for I. indigotica root extract, indigo, sinigrin, aloe emodin and hesperetin. Sinigrin(IC50: 217 microM) was more efficient in blocking the cleavage processing of the 3CLpro than indigo (IC50: 752 microM) and beta-sitosterol (IC50: 1210 microM) in the cell-based assay. Only two phenolic compounds aloe emodin and hesperetin dose-dependently inhibited cleavage activity of the 3CLpro, in which the IC50 was 366 microM for aloe emodin and 8.3 microM for hesperetin in the cell-based assay, according to "Anti-SARS coronavirus 3C-like protease effects of Isatis indigotica root and plant-derived phenolic compounds" by Lin CW, Tsai FJ, Tsai CH, Lai CC, Wan L, Ho TY, Hsieh CC, Chao PD.(7)

8. Colorectal cancer
In the investigation of raw juice extracted from Brussels sprouts rich in the glucosinolate sinigrin to explore the effect of naturally occurring glucosinolate breakdown products on cell cycle progression and apoptosis in human colorectal carcinoma cells (HT29), found that the main glucosinolate breakdown products were as follows: the sinigrin breakdown product, 1-cyano-2,3-epithiopropane (ca. 38 mM); the gluconapin hydrolysis product, 3-butenyl isothiocyanate (ca. 2.2.mM); the glucobrassicin metabolite, ascorbigen (ca. 8 mM); and low concentrations of other indole glucosinolate-derived hydrolysis products such as neoascorbigen and 3,3'-diindolylmethane. A variety of biologically active glucosinolate breakdown products are released by mechanical disruption of raw Brussels sprout tissue, but contrary to previous assumptions, allyl isothiocyanate is not the main compound responsible for the inhibition of cell proliferation, according to "Effects of Brussels sprout juice on the cell cycle and adhesion of human colorectal carcinoma cells (HT29) in vitro" by Smith TK, Lund EK, Clarke RG, Bennett RN, Johnson IT.(8)

9. Tumor cell proliferation and cyclooxygenase inhibitory
In the investigation of Cyclooxygenase and human tumor cell growth inhibitory from 5 compounds, namely plastoquinone-9 (1), 6-O-acyl-beta-d-glucosyl-beta-sitosterol (2), 1,2-dilinolenoyl-3-galactosylglycerol (3), linolenoyloleoyl-3-beta-galactosylglycerol (4), and 1,2-dipalmitoyl-3-beta-galactosylglycerol (5). 3-Acyl-sitosterols, sinigrin, gluconasturtiin, and phosphatidylcholines isolated from horseradish and alpha-tocopherol and ubiquinone-10 from wasabi rhizomes, showed that Compounds 3, 4, and 5 gave 75, 42, and 47% inhibition of COX-1 enzyme, respectively, at a concentration of 250 microg/mL. In a dose response study, compound 3 inhibited the proliferation of colon cancer cells (HCT-116) by 21.9, 42.9, 51.2, and 68.4% and lung cancer cells (NCI-H460) by 30, 39, 44, and 71% at concentrations of 7.5, 15, 30, and 60 microg/mL, respectively. At a concentration of 60 microg/mL, compound 4 inhibited the growth of colon, lung, and stomach cancer cells by 28, 17, and 44%, according to "Tumor cell proliferation and cyclooxygenase inhibitory constituents in horseradish (Armoracia rusticana) and Wasabi (Wasabia japonica)" by Weil MJ, Zhang Y, Nair MG.(9)

10. Antioxidants
In the examination of the effect of an aqueous extract of cooked Brussels sprouts on formation of 7-hydro-8-oxo-2'-deoxyguanosine (8-oxodG) in calf thymus DNA in vitro, found that Sinigrin, a glucosinolate abundant in Brussels sprouts, co-eluted with the most effective fraction and had DNA protective effects. In comparison with other antioxidants the patterns of effect of the extract in the five damage systems were more similar to that of sodium azide than to those of dimethylsulfoxide and vitamin C, according to "Inhibition of oxidative DNA damage in vitro by extracts of brussels sprouts" by Zhu C, Poulsen HE, Loft S.(10)

11. Etc.

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

Sources(1) http://www.ncbi.nlm.nih.gov/pubmed/20889681
(2) http://www.ncbi.nlm.nih.gov/pubmed/20809411
(3) http://www.ncbi.nlm.nih.gov/pubmed/20530888
(4) http://www.ncbi.nlm.nih.gov/pubmed/19346022
(5) http://www.ncbi.nlm.nih.gov/pubmed/16565438
(6) http://www.ncbi.nlm.nih.gov/pubmed/16277393
(7) http://www.ncbi.nlm.nih.gov/pubmed/16115693
(8) http://www.ncbi.nlm.nih.gov/pubmed/15884814
(9) http://www.ncbi.nlm.nih.gov/pubmed/15740020
(10) http://www.ncbi.nlm.nih.gov/pubmed/10885626

Most common Diseases Free and Longevity of 50 plus - Turmeric Part C By Foods to prevent and treat diseases

Over the years of research, 4 foods appeared mostly in medical studies in preventing and treating diseases, are Green Tea, Grape seed and skin, Turmeric and Organic Soy(Not for Western Women). All Right Reserved.

III. Turmeric
Turmeric, principal curcuminoid of the popular Indian spice, a rhizomatousherbaceous perennial plant of the ginger family, Zingiberaceae, native totropical South Asia, according to "Effects of different drying methods on the antioxidant properties of leaves and tea of ginger species" by E.W.C. Chan, Y.Y. Lim, S.K. Wong, K.K. Lim, S.P. Tan, F.S. Lianto and M.Y. Yong, posted in Science Direct. It has been used in traditional herbal medicine as an anti-inflammatory agent and to treat gastrointestinal symptoms associated with irritable bowel syndrome and other digestive disorders. Curcumin is a phytochemical found abundant in the plant. In acidic solutions (pH <7.4) it turns yellow, whereas in basic (pH > 8.6) solutions it turns bright red.

C. By Foods to prevent and treat diseases
1. Anxiety
In the study to evaluate the effect of curcumin (10 and 20mg/kg), an active constituent of Curcuma longa was evaluated for its antianxiety-like activity in mice subjected to immobilization-induced restraint stress for 6h, indicated that the combination of aminoguanidine and curcumin significantly decreased the plasma nitrite levels as compared to curcumin and aminoguanidine per se in stressed mice. Curcumin and aminoguanidine did not produce any significant change in brain GABA contents of the animals. Diazepam (2mg/kg) produced significant anxiolytic-like effect only in unstressed mice, but could not exert significant anxiolysis in stressed mice. However, diazepam significantly increased GABA contents in both unstressed and stressed mice as compared to respective control groups. These findings suggest the possible involvement of only inducible NOS and not neuronal NOS in antianxiety-like effect of curcumin(1).

2. Alzheimer's disease
Turmeric, principal curcuminoid of the popular Indian spice, a rhizomatousherbaceous perennial plant of the ginger family, Zingiberaceae, native to tropicalSouth Asia, according to "Effects of different drying methods on the antioxidant properties of leaves and tea of ginger species" by E.W.C. Chan, Y.Y. Lim, S.K. Wong, K.K. Lim, S.P. Tan, F.S. Lianto and M.Y. Yong, posted in Science Direct. It has been used in traditional herbal medicine as an anti-inflammatory agent and to treat gastrointestinal symptoms associated with irritable bowel syndrome and other digestive disorders.
Curcumin is a phytochemical found abundant in the plant. In acidic solutions (pH <7.4) it turns yellow, whereas in basic (pH > 8.6) solutions it turns bright red.
In other study of `NSAID and antioxidant prevention of Alzheimer's disease: lessons from in vitro and animal models.`by Cole GM, Morihara T, Lim GP, Yang F, Begum A, Frautschy SA. (Source from Greater Los Angeles Healthcare System, Veterans Administration Medical Center, North Hills, CA 91343, USA. gmcole@ucla.edu) posted in US National Library of Medicine National Institutes of Health, reseachers found that the unconventional NSAID/antioxidant curcumin was effective, lowering oxidative damage, cognitive deficits, synaptic marker loss, and amyloid deposition. Curcumin proved to be immunomodulatory, simultaneously inhibiting cytokine and microglial activation indices related to neurotoxicity, but increasing an index of phagocytosis. Curcumin directly targeted Abeta and was also effective in other models, warranting further preclinical and clinical exploration(2).

3. Rheumatoid Arthritis (RA)
Turmeric (Curcuma longa L., Zingiberaceae) rhizomes contain two classes of secondary metabolites, curcuminoids and the less well-studied essential oils. Dr. Funk JL and research team at the University of Arizona, indicated that Crude or refined TEO extracts dramatically inhibited joint swelling (90-100% inhibition) in female rats with streptococcal cell wall (SCW)-induced arthritis when extracts were administered via intraperitoneal injection to maximize uniform delivery. However, this anti-arthritic effect was accompanied by significant morbidity and mortality. Oral administration of a 20-fold higher dose TEO was nontoxic, but only mildly joint-protective (20% inhibition). These results do not support the isolated use of TEO for arthritis treatment but, instead, identify potential safety concerns in vertebrates exposed to TEO(3).

4. Polymalagia Arthritis(PMR)
Turmeric, principal curcuminoid of the popular Indian spice, a rhizomatousherbaceous perennial plant of the ginger family, Zingiberaceae, native to tropicalSouth Asia.
a. Anti inflammatory effects
In a systematic review of the literature was to summarize the literature on the safety and anti-inflammatory activity of curcumin, found that curcumin has been demonstrated to be safe in six human trials and has demonstrated anti-inflammatory activity. It may exert its anti-inflammatory activity by inhibition of a number of different molecules that play a role in inflammation, according to "Safety and anti-inflammatory activity of curcumin: a component of tumeric (Curcuma longa)" by Chainani-Wu N (4)
b. Antioxidants
In the research of a literature search (PubMed) of almost 1500 papers dealing with curcumin, most from recent years, with ll available abstracts were read and pproximately 300 full papers were reviewed, found that curcumin, a component of turmeric, has been shown to be non-toxic, to have antioxidant activity, and to inhibit such mediators of inflammation as NFkappaB, cyclooxygenase-2 (COX-2), lipooxygenase (LOX), and inducible nitric oxide synthase (iNOS). Significant preventive and/or curative effects have been observed in experimental animal models of a number of diseases, including arteriosclerosis, cancer, diabetes, respiratory, hepatic, pancreatic, intestinal and gastric diseases, neurodegenerative and eye diseases, "Curcumin, an atoxic antioxidant and natural NFkappaB, cyclooxygenase-2, lipooxygenase, and inducible nitric oxide synthase inhibitor: a shield against acute and chronic diseases" by Bengmark S.(4a)

5. Chlamydia
In the study to evaluate the Berberine of a plant alkaloid with a long history of medicinal use in both Ayurvedic and Chinese medicine, presented abundantly inturmeric, found that erberine extracts and decoctions have demonstrated significant antimicrobial activity against a variety of organisms including bacteria, viruses, fungi, protozoans, helminths, and chlamydia. Currently, the predominant clinical uses of berberine include bacterial diarrhea, intestinal parasite infections, and ocular trachoma infections(5)

6. Chronic obstructive pulmonary disease (COPD)
Cadmium is a toxic metal present in the environment and its inhalation can lead topulmonary disease such as lung cancer and chronic obstructive pulmonary disease. These lung diseases are characterized by chronic inflammation. In the study of Curcumin regulates airway epithelial cell cytokine responses to the pollutant cadmium, researchers found that the natural antioxidant curcumin could prevent both cadmium-induced IL-6 and IL-8 secretion by human airway epithelial cells. In conclusion, curcumin could be used to prevent airway inflammation due to cadmium inhalation(6).

7. Diabetes
In the evaluation of the effect of feeding 0.5% curcumin diet or 1% cholesterol diet in albino rats rendered diabetic with streptozotocin injection, indicated that curcumin feeding improves the metabolic status in diabetic conditions, despite no effect on hyperglycemic status or the body weights. The mechanism by which curcumin improves this situation is probably by virtue of its hypocholesterolemic influence, antioxidant nature and free radical scavenging property(7).

8. Depression
Curcumin is a major active compound of Curcuma longa. In the study to investigate the effect of curcumin on endogenous glutamate release in nerve terminals of rat prefrontal cortex and the underlying mechanisms, suggested thatcurcumin inhibits evoked glutamate release from rat prefrontocortical synaptosomes by the suppression of presynaptic Ca(v)2.2 and Ca(v)2.1 channels. The inhibitory effect of curcumin on 4-AP-evoked glutamate release was completely abolished by the clinically effective antidepressant fluoxetine. This suggests that curcumin and fluoxetine use a common intracellular mechanism to inhibit glutamate release from rat prefrontal cortex nerve terminals(8).

9. Crohn's disease
The up regulation of gut mucosal cytokines such as tumor necrosis factor (TNF)-α and oxidative stress have been related to inflammatory bowel diseases (IBD) such as ulcerative colitis (UC) and Crohn's disease (CD). In the study to investigate an immune-mediated model of colitis. TNF-α injected intraperitonally to mice induced a dose-dependent recruitment of neutrophils into abdominal mesentery, showed that AG and Cur treatments significantly attenuated the hallmarks of oxidative stress, neutrophils influx and ROS-related cellular and histological damages, in TNF-α-treated mice. Taken together, our results provide insights into the role of phagocytes-derived oxidants in TNF-α-colitis in mice. Cur and AG, by inhibiting neutrophils priming and iNOsynthase could be effective against oxidative bowel damages induced in IBD by imbalanced gut immune response(9).

10. Fibroids
Uterine leiomyomas are the most common gynaecological benign tumour and greatly affect reproductive health and wellbeing. Curcumin, a well-known component of turmeric, has been reported to prevent various diseases such as cancer, diabetes and obesity. Researchers at Tohoku University Graduate School of Medicine, suggested that curcumin significantly inhibited ELT-3 cell proliferation. PPARγ was expressed in ELT-3 cells and curcumin acted as a PPARγ ligand. This inhibitory effect of curcumin was attenuated by the treatment of cells with PPARγ antagonist(10).

11. Flu (influenza)
In the studt to investigate selected polyphenols for their antiviral activity againstinfluenza A and B viruses. Among the polyphenols, isoquercetin inhibited the replication of both influenza A and B viruses at the lowest effective concentration. In a double treatment of isoquercetin and amantadine, synergistic effects were observed on the reduction of viral replication in vitro. The serial passages of virus in the presence of isoquercetin did not lead to the emergence of resistant virus, and the addition of isoquercetin to amantadine or oseltamivir treatment suppressed the emergence of amantadine- or oseltamivir-resistant virus. In a mouse model ofinfluenza virus infection, isoquercetin administered intraperitoneally to mice inoculated with human influenza A virus significantly decreased the virus titers and pathological changes in the lung. Our results suggest that isoquercetin may have the potential to be developed as a therapeutic agent for the treatment of influenzavirus infection and for the suppression of resistance in combination therapy with existing drugs.(11).

12. Hepatitis
Curcumin has not only shown anti-inflammatory, anti-oxidant, antifungal, antibacterial and anticancer activities but also has had the ability to inhibit several factors like nuclear factor-kappaB, which modulates several pro-inflammatory and profibrotic cytokines as well as its anti-oxidant properties, provide a rational molecular basis to use it in hepatic disorders. Curcumin attenuates liver injury induced by ethanol, thioacetamide, iron overdose, cholestasis and acute, subchronic and chronic carbon tetrachloride (CCl(4)) intoxication; moreover, it reverses CCl(4) cirrhosis to some extent(12).

13. Genital herpes
In the study to investigate Curcumin, a phenolic compound from the curry spiceturmeric in exhibiting a wide range of activities in eukaryotic cells, including antiviral effect, found that curcumin affects VP16-mediated recruitment of RNA polymerase II to IE gene promoters by a mechanism independent of p300/CBP histone acetyltransferase activity(13).

14. Irritable bowel syndrome
In the study to assess the effects of turmeric (Curcuma longa) extract on irritable bowel syndrome (IBS) symptomology in otherwise healthy adults, indicated thatIBS prevalence decreased significantly in both groups between screening and baseline (41% and 57%), with a further significant drop of 53% and 60% between baseline and after treatment, in the one- and two-tablet groups respectively (p < 0.001). A post-study analysis revealed abdominal pain/discomfort score reduced significantly by 22% and 25% in the one- and two-tablet group respectively, the difference tending toward significance (p = 0.071). There were significant improvements in all bar one of the IBSQOL scales of between 5% and 36% in both groups, approximately two thirds of all subjects reported an improvement in symptoms after treatment, and there was a favorable shift in self-reported bowel pattern(14).

15. Liver disease
In the stdu8y to evaluate the protective role of soy against CCl(4)-induced liverdamage in rats as four experimental groups were treated for 8 weeks and included the control group,showed that Supplementation with soy succeeded to restore the elevation of liver enzymes activities and improved serum biochemical parameters. Moreover, soy supplementation improved the antioxidant enzymes, decreased lipid peroxidation, and improved the histological picture of the liver tissue. It could be concluded that soy-protein-enriched isoflavones may be a promising agent againstliver diseases(15).

16. Lupus Cerebritis
c. Anti inflammatory effects
In a systematic review of the literature was to summarize the literature on the safety and anti-inflammatory activity of curcumin, found that curcumin has been demonstrated to be safe in six human trials and has demonstrated anti-inflammatory activity. It may exert its anti-inflammatory activity by inhibition of a number of different molecules that play a role in inflammation, according to "Safety and anti-inflammatory activity of curcumin: a component of tumeric (Curcuma longa)" by Chainani-Wu N.

b. Antioxidants
In the research of a literature search (PubMed) of almost 1500 papers dealing with curcumin, most from recent years, with ll available abstracts were read and pproximately 300 full papers were reviewed, found that curcumin, a component of turmeric, has been shown to be non-toxic, to have antioxidant activity, and to inhibit such mediators of inflammation as NFkappaB, cyclooxygenase-2 (COX-2), lipooxygenase (LOX), and inducible nitric oxide synthase (iNOS). Significant preventive and/or curative effects have been observed in experimental animal models of a number of diseases, including arteriosclerosis, cancer, diabetes, respiratory, hepatic, pancreatic, intestinal and gastric diseases, neurodegenerative and eye diseases, "Curcumin, an atoxic antioxidant and natural NFkappaB, cyclooxygenase-2, lipooxygenase, and inducible nitric oxide synthase inhibitor: a shield against acute and chronic diseases" by Bengmark S.

c. Neuroprotective effect
In the finding of the A Potential Neuroprotective Agent in treating Parkinson's Disease, found that curcumin exhibits antioxidant, anti-inflammatory and anti-cancer properties, crosses the blood-brain barrier and is neuroprotective in neurological disorders. Several studies in different experimental models of PD strongly support the clinical application of curcumin in PD. The current review explores the therapeutic potential of curcumin in PD, according to "Curcumin: A Potential Neuroprotective Agent in Parkinson's Disease" by Mythri RB, Bharath MS.

17. Multiple sclerosis
In the study of Curcuminoids in Neurodegenerative Diseases, by Dr. Kim DS and research team at the Core LifeSource Inc., showed that curcuminoids found in turmeric prevent β-synuclein aggregation in PD; attenuate ROS-induced COX-2 expression in ALS; ameliorate the symptoms of MS, DE and traumatic brain injury, in addition to neurodamages caused by heavy metal poisoning(4). Others suggested that Curcumin, a dietary spice from turmeric, has outstanding anti-inflammation and neuroprotective effects(17).

18. Obesity
In the study to investigate the effect of curcumin, the major polyphenol in turmeric spice, on angiogenesis, adipogenesis, differentiation, apoptosis, and gene expression involved in lipid and energy metabolism in 3T3-L1 adipocyte in cell culture systems and on body weight gain and adiposity in mice, found that in vivo effect of curcumin on the expression of these enzymes was also confirmed by real-time RT-PCR in subcutaneous adipose tissue. In addition, curcumin significantly lowered serum cholesterol and expression of PPARgamma and CCAAT/enhancer binding protein alpha, 2 key transcription factors in adipogenesis and lipogenesis. The curcumin suppression of angiogenesis in adipose tissue together with its effect on lipid metabolism in adipocytes may contribute to lower body fat and body weight gain(18).

19. Pelvic inflammatory disease
According to the study of evaluation of anti-inflammatory property of curcumin (diferuloyl methane) in patients with postoperative inflammation by Satoskar RR, Shah SJ, Shenoy SG., poated in US National Library of Medicine National Institutes of Health, researchers wrote that In this model of postoperative inflammation, the anti-inflammatory activity of curcumin (diferuloyl methane) was investigated in comparison with phenylbutazone and placebo. Phenylbutazone and curcumin produced a better anti-inflammatory response than placebo(19).

20. Etc.

Side effects
1. Overdose may cause gastrointestinal discomfort such as nausea and diarrhea and liver damage.
2. Topical use may be allergic to skin such irritation to certain peoples
3. Do not use the herb in new born, children or if you are pregnant and breast feeding without approval from the related field specialist.
4. Etc.

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(1) " Dietary protein and exercise have additive effects on body composition duringweight loss in adult women." by Layman DK, Evans E, Baum JI, Seyler J, Erickson DJ, Boileau RA., Posted in PubMed