Medical Advisor Journals

Sunday, May 29, 2016

The Smoothie of Orange, Yogurt and Honey for Prevention and Treatment of Vaginal Bleeding in Menopause caused by vaginal yeast infection

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The finding of a natural source for reduced risk and treatment of Vaginal Bleeding has encountered many obstacles, many ingredients showed initially the promising result in animal studies have not produced same potentials in either large sample size and mutli centers human trials.

Scientists in some well known institutions may have found the therapeutic and potential ingredients from natural sources(Green tea and grape) for reduced risk and treatment of pospartum depression.

Abnormal vaginal bleeding is a bleeding when you do not suppose to such as menopause, pregnancy or when your menstruation is lighter or heavier than it should be.

The Incredible and Effective smoothie for Prevention and treatment of Vaginal Bleeding in Menopause caused by vaginal yeast infection
Yield: 2 servings (about 8 ounces each)
1 cup orange
1/4 cup yogurt
1/4 cup honey

1 cup ginger herbal tea

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately

Candida albicans are members of a large group of micro organism whose cells contain complex structures enclosed within the membranes, including yeast, fungi, and mold that live among the gut flora in the human mouth and gastrointestinal tract. In fact, under normal circumstances, Candida albicans that do not cause harmful effects, but overgrowth results in candidiasis(1)

The finding of a natural source for reduced risk and treatment of vaginal yeast infection to replace the conventional medicine has been running into many obstacles, many ingredients showed initially with promising result in animal studies have not produced same potentials in either large sample size and mutli centers human trials.

Yogurt, make from whole milk may consist a powerful ingredient for prevention and treatment of Vaginal yeast infection as its promote the suppression of C. albicans growth through Lactobacillus colonization the in the reproductive tract(2).

The study of the Central Emek Hospital, Afula, Israel, insisted, "daily ingestion of 150 mL of yogurt, enriched with live L acidophilus, was associated with an increased prevalence of colonization of the rectum and vagina by the bacteria, and this ingestion of yogurt may have reduced episodes of BV."(3).

Vitamin C found abundantly in orange, a water soluble vitamin, as free radical scavengers and regenerated oxidized vitamin E for immune support may be a potential ingredient for treatment of vaginal yeast infection(4).
Feminella Vagi C, a commercial product of Vitamin C (Ascorbic Acid) exhibited anti bacterial vaginosis (BV) and/or mycotic infection activity when used conjunction with Nifuratel, Nistatin)(5) leading to higher percentage of clinically recovery (86.7% vs 84.6%), better microbiological cleaning (86.7% vs 82.1%) and longer effect of treatment.

Ginger (Zingiber officinale) or ginger root is the genus Zingiber, belongings to the family Zingiberaceae, native to Tamil, used in traditional and Chinese medicine to treat morning sickness, gastroparesis, constipation,...etc. According to the Teikyo University Institute of Medical Mycology, ginger essential oils, and particularly those from seed and air-dried rhizomes, had potent inhibitory activity, particular the 6]-shogaol constituent(6).

Dr. Giriraju A and Dr. Yunus GY. said, " 10% ethanolic ginger extract showed: (a) Maximum zone of inhibition of 8 mm, 14 mm, and 11 mm against S. mutans, C. albicans, and E. faecalis respectively. (b) MIC of 1.25%, 2.5%, and 2.5% against S. mutans, C. albicans, and E. faecalis respectively"(7).

Interestingly, the Institute of Veterinary Sciences University Ibn-KhadounTiaret, study suggested that use of ginger starch may allow honey benefit in constituted an alternative way against the resistance to antifungal agents(8).

The effectiveness of Orange, Yogurt, Honey and Ginger may serve as cornerstones of pharmaceutical target for further studies in production of a potential medication for for Reduced Risk and treatment of vaginal yeast infection with little or no adverse effects.

Women who are at increased risk of vaginal yeast infection may drink at least one serving daily and women with vaginal yeast infection may drink as much as they can, depending to the digestive toleration.
Life style and dietary patter change are recommended.

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

References
(1) The Reader Guide To Cure Candidiasis: Testing Candidiasis by Kyle J. Norton

(2) Utility of the oestrogen-dependent vaginal candidosis murine model in evaluating the efficacy of various therapies against vaginal Candida albicans infection by Hamad M1, Muta'eb E, Abu-Shaqra Q, Fraij A, Abu-Elteen K, Yasin SR.(PubMed)

(3) Ingestion of yogurt containing Lactobacillus acidophilus compared with pasteurized yogurt as prophylaxis for recurrent candidal vaginitis and bacterial vaginosis by Shalev E1, Battino S, Weiner E, Colodner R, Keness Y.(PubMed)
(4) Vulvovaginitis: screening for and management of trichomoniasis, vulvovaginal candidiasis, and bacterial vaginosis by van Schalkwyk J1, Yudin MH2; Infectious Disease Committee, Yudin MH2, Allen V3, Bouchard C4, Boucher M5, Boucoiran I1, Caddy S6, Castillo E6, Kennedy VL2, Money DM1, Murphy K2, Ogilvie G1, Paquet C7, van Schalkwy JK1; Society of Obstetricians and Gynaecologists of Canada.(PubMed)
(5) [Multipurpose treatment of vaginal infections].[Article in Bulgarian] by Nikolov A, Masseva A, Shopova E, Georgiev S.(PubMed)
(6) Anti-Candida and radical scavenging activities of essential oils and oleoresins of Zingiber officinale Roscoe and essential oils of other plants belonging to the family Zingiberaceae by Takahashi M1, Inouye S, Abe S.(PubMed)
(7) Assessment of antimicrobial potential of 10% ginger extract against Streptococcus mutans, Candida albicans, and Enterococcus faecalis: an in vitro study by Giriraju A1, Yunus GY.(PubMed)
(9) Additive potential of ginger starch on antifungal potency of honey against Candida albicans by Moussa A1, Noureddine D, Hammoudi SM, Saad A, Bourabeh A, Houari H(PubMed)

Most common Diseases Free and Longevity of 50 plus - Organic Soy(The Articles) Soy and the risk of Prostate cancer in Japanese Men

Over the years of research, 4 foods appeared mostly in medical studies in preventing and treating diseases, are Green Tea, Grape seed and skin, Turmeric and Organic Soy(Not for Western Women). All Right Reserved.

IV. Organic Soy
Soy foods, including tofu have been in traditional Chinese diet over thousands of year, according to Chinese literature. The reduced risk of chronic disease in Asian population, including metabolic syndrome such as cardiovascular diseases, obesity and diabetes and lesser menopause symptoms in advanced age, may be aided by eating a lot of soy food accompanied with large portion of vegetables and fruits. Indeed, according to the study, only 10% of women in the East are experience symptoms of menopause in advanced age compared to over 70% of their Western counterparts.
According to Dr. Mark Messina, Ph.D., Soy foods contributed from 6.5%8 to 12.8%7 of total protein intake in older adult in Japan.(b)

The approval of cardiovascular benefit of soy by FDA in 1999 accompanied with the discovery of health benefits in clinical studies over past decade, prompted the promotion and advertisement of soy's health benefits in every aspect in Western society. Evidences could be seen by walking through the supermarkets and drug stores. Soy supplements and products such as tofu, soy milk, soy-based infant formula, and meatless “texturized vegetable protein” burgers were widely available. According to the United Soybean Board’s 2004–2005, 25% of Americans consumed soy foods or beverages at least once per week, and 74% viewed soy products as healthy.

Today, the promotion of soy is no longer existed, it may be results of discovery of adverse effects in single ingredient and animal studies, as intake of soy is associated to induce risk of certain mammary cancers and infertility. The publication of the result have drawn many criticisms. According to Thomas Badger, director and senior investigator at the Arkansas Children’s Nutrition Center in Little Rock, these effects are seen only under certain experimental conditions that are not likely to occur in humans—and therein lies the crux of the debate(a).Equol (4',7-isoflavandiol), an isoflavandiol metabolized from daidzein may be the causes, as 90% of Eastern population are equol producers but only 30% in the West.
The explanation of the positive effect of soy isoflavones in reduced risk of mammary cancers by University of Goettingen may be interesting, as researchers said" Most importantly, there is dispute as to whether isoflavones derived from soyor red clover have negative, positive or any effect at all on the mammary gland or endometrium. It is beyond any doubt that soy products may have cancerpreventing properties in a variety of organs including the mammary gland. However, these properties may only be exerted if the developing organ was under the influence of isoflavones during childhood and puberty".

Soybean is genus Glycine, the family Fabaceae, one of the legumes that contains twice as much protein per acre as any other major vegetable or grain crop, native to Southeast Asia. Now, it is grown worldwide with suitable climate for commercial profit and a a healthy foods.

Nutrients
1. Carbohydrates
2. Dietary fiber
3. Fat
4. Protein
5. Essential amino acid
6. Vitamin A
7. Vitamin B6
8. Vitamin B12
9. Vitamin C
10. Vitamin K
11. Calcium
12. Iron
13. Magnesium
14. Phosphorus
15. Potassium
16. Sodium
17. Zinc
18. Etc.
Phytochemicals
1. Isoflavones
2. Genistein
3. Saponins
4. Beta-sitosterol
5. Daidzein

I. The Articles (Soy in The Japanese population)

Japan, an island nation in the Pacific Ocean, lies to the east of the Sea of Japan, China, North Korea, South Korea and Russia, stretching from the Sea of Okhotsk in the north to the East China Sea and Taiwan in the south(1). According to Moriyama, Japanese women and men live longer and healthier than everyone else on Earth, it may be result of healthier Japanese diet and lifestyle. According to the World Health Organization, the Japanese have an average of 75 years healthy living with disability-free, it may be due to average soy intake 10 to 70 times higher than in Western people(1a)(1b).

Soy and Prostate cancer in Japanese Men

Prostate cancer is defined as a condition in which the cells of prostate has become cancerous, causing abnormal cell growth with possibility of spreading to the distant parts of the body. Most prostate cancers are slow growing and enlarged prostate and prostate cancer may be detected during physical (rectum) exams.

The widespread of prostate cancer, once considered a disease of aging male, now have become major concerns of governments and scientific community in South East Asian with tendency to effect even younger age population. Suggestions emerged of over consuming bad fats in any time in history accompanied with unhealthy diet and life style may be the possible causes of the disease, linking to the economic prosperity over 2 decades.

In fact, the incidence of prostate cancer in Asia is still lower if compared to their Western counterparts.
The Research Center for Cancer Prevention and Screening, National CancerCenter. suggested that isoflavones and soy food are associated with a dose-dependent decrease in the reduced risk of localized cancer, in a population-based prospective study in 43,509 Japanese men ages 45 to 74 years with participants responded to a validated questionnaire, which included 147 food items. During follow-up from 1995 through 2004, 307 men were newly diagnosed with prostate cancer, of which 74 cases were advanced, 220 cases were organ localized, and 13 cases were of an undetermined stage(5).

Environment, Diet, intestinal microbiota and Geography
The testing of North American Japanese and Japanese in Japan showed the environment factor may be involved in the development of prostate cancer regardless to genetic similarity(7). The incidence of the disease increased vary both from country to country and ethnic group, with the highest incidence reported for Afro-Americans and the lowest for Asian men(2).

The study of the associations between nutritional and other lifestyle factors and the prevalence of prostate cancer in a case-control study of Japanese men, showed that soy isoflavone significantly decreased the risk of prostate cancerregardless to the intake of other nutrients such as PUFA, (n-6) fatty acids or magnesium from other food sources(9).

Other suggested that legumes (not limited to soy products) and certain categories of vegetables may protect against prostate cancer(10).

DR. Akaza H. said "not having equol converting bacteria in the intestine (non-equol producers) can be a risk factor for prostate cancer and that one direction for future research will be to examine the possibility of improving the intestinal environment to enable equol production"(13).

Genes differentiation
1n gene differentiation, estrogen related genes may be the culprits for the development of prostate cancer. In an one hundred and eighty cases and 177 controls selected from three geographic areas of Japan study, though analysis by the multifactor dimensionality reduction method, soy isoflavones, showed to exhibit its anti prostate cancer, depending to differ between the genotypes of estrogen related genes(3).
According to Dr. Kimura T., the incidence of prostate cancer in Asia is much lower than that in African Americans and European Caucasians and soy food consumption, more popular in Asian populations, is associated with a 25% to 30% reduced risk of prostate cancer, it may be as a result of genetic mutation of approximately 30 genetic polymorphisms in populations of countries in the West.(1).

Serum of isoflavones
In a case-control study within the Japan Public Health Center-based Prospective of a total of 14,203 men aged 40 to 69 years who had returned the baseline questionnaire and provided blood samples observed from 1990 to 2005, showed that plazma genistein level is associated inversely to the risk of prostate cancer(4).

Other in the study of four isoflavonoids in plasma of 14 Japanese and 14 Finnish men, also showed that the mean plasma of total individual isoflavonoid levels of Japnaese are 7 to 110 times higher Japanese than in the Finnish men. Genistein, a tyrosine kinase inhibitor, occurred in the highest concentration(11).

In the experiment of Urinary excretion of lignans and isoflavonoid phytoestrogens in Japanese men and women consuming a traditional Japanese diet showed that the excretion of isoflavonoids correlated with soybean-product intake is associated to reduced mortality in breast and prostate cancer of Japanese women and men(12).

In view of above, the Loma Linda University, insisted that soy isoflavones should be tested against different populations of prostate cancer patients for its efficacy(6). Other suggested that the lower incidence of prostate cancer in Japanese men may be a result of traditional Japanese diet with a lot of soy foods and fishes(8) and promotes the production of Soy-derived food products and the metabolization of the isoflavones to enhance equol production to those of non producers of Asian and European/North American populations(13).

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to 1000 free AND HEALTHY recipes and counting
http://kylejnorton.blogspot.ca/p/recipes.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

References
(1) East meets West: ethnic differences in prostate cancer epidemiology between East Asians and Caucasians by Kimura T.(PubMed)
(2) Hereditary prostate cancer and other genetic predispositions to prostate cancer by Cussenot O1, Valeri A, Berthon P, Fournier G, Mangin P.(PubMed)
(3) Polymorphisms in estrogen related genes may modify the protective effect of isoflavones against prostate cancer risk in Japanese men by Sonoda T1, Suzuki H, Mori M, Tsukamoto T, Yokomizo A, Naito S, Fujimoto K, Hirao Y, Miyanaga N, Akaza H.(PubMed)
(4) Plasma isoflavones and subsequent risk of prostate cancer in a nested case-control study: the Japan Public Health Center by Kurahashi N1, Iwasaki M, Inoue M, Sasazuki S, Tsugane S.(PubMed)
(5) Soy product and isoflavone consumption in relation to prostate cancer inJapanese men by Kurahashi N1, Iwasaki M, Sasazuki S, Otani T, Inoue M, Tsugane S; Japan Public Health Center-Based Prospective Study Group.(PubMed)
(6) An overview of the health effects of isoflavones with an emphasis on prostate cancer risk and prostate-specific antigen levels by Messina M1, Kucuk O, Lampe JW.(PubMed)
(7) Prostate cancer in native Japanese and Japanese-American men: effects of dietary differences on prostatic tissue by Marks LS1, Kojima M, Demarzo A, Heber D, Bostwick DG, Qian J, Dorey FJ, Veltri RW, Mohler JL, Partin AW.(PubMed)
(8) A case-control study of diet and prostate cancer in Japan: possible protective effect of traditional Japanese diet by Sonoda T1, Nagata Y, Mori M, Miyanaga N, Takashima N, Okumura K, Goto K, Naito S, Fujimoto K, Hirao Y, Takahashi A, Tsukamoto T, Fujioka T, Akaza H.(PubMed)
(9) Nagata Y1, Sonoda T, Mori M, Miyanaga N, Okumura K, Goto K, Naito S, Fujimoto K, Hirao Y, Takahashi A, Tsukamoto T, Akaza H.(PubMed)
(10) Vegetables, fruits, legumes and prostate cancer: a multiethnic case-control study by Kolonel LN1, Hankin JH, Whittemore AS, Wu AH, Gallagher RP, Wilkens LR, John EM, Howe GR, Dreon DM, West DW, Paffenbarger RS Jr.(PubMed)
(11) Plasma concentrations of phyto-oestrogens in Japanese men by Adlercreutz H1, Markkanen H, Watanabe S.(PubMed) (12) Urinary excretion of lignans and isoflavonoid phytoestrogens in Japanese men and women consuming a traditionalJapanese diet by Adlercreutz H1, Honjo H, Higashi A, Fotsis T, Hämäläinen E, Hasegawa T, Okada H.(PubMed)
(13) Prostate cancer chemoprevention by soy isoflavones: role of intestinal bacteria as the "second human genome" by Akaza H.(PubMed)

Saturday, May 28, 2016

Herbal therapy: Popular Herbal Devil's Club(Oplopanax horridus)

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Devil's Club

Devil's Club is a large shrub, genus Oplopanax, belonging to the family Aralioideae, native to the cool moist forests of western North America. The herb has been used in traditional and herbal medicine as Adaptogen, Antipyretic, Pain Reliever, Antitussive, Antibacterial agent and to treat Arthritis, Diabetes, Colds, Cough, Sore throat, Chest congestion, Stomach pain, Constipation, Gall stones, Influenza, Cancer, etc.

Health Effects
1. Antimycobacterial polyynes
In the investigation of isolated polyynes isolated from Devil's Club (Oplopanaxhorridus; Araliaceae) and its antimycobacterial effects found that polyynes exhibited significant anti-Candida, antibacterial, and antimycobacterial activity, with an ability to kill Mycobacterium tuberculosis and isoniazid-resistant Mycobacterium avium at 10 micrograms/disk in a disk diffusion assay, according to the study of "Antimycobacterial polyynes of Devil's Club (Oplopanaxhorridus), a North American native medicinal plant' by Kobaisy M, Abramowski Z, Lermer L, Saxena G, Hancock RE, Towers GH, Doxsee D, Stokes RW.(1)

2. Anticancer activities
In the investigation of Devil's Club (Oplopanax horridus) is one of the most important spiritual and medicinal plants to many indigenous peoples of Alaska and the Pacific Northwest. and its potential anticancer activity found that Hydrophobic falcarindiol extracted from the herb possesses the strongest activity. Further cell cycle and apoptosis tests by flow cytometry showed the polyacetylenes 1-4 induced HCT-116 cell arresting in G2/M phase and inhibited proliferation by the induction of apoptosis at both earlier and later stages, according to "Hydrophobic constituents and their potential anticancer activities from Devil's Club(Oplopanax horridus Miq.)" by Sun S, Du GJ, Qi LW, Williams S, Wang CZ, Yuan CS.(2)

3. Anti-proliferative and antioxidant effects
In the analyzing Devil's Club, Oplopanax horridus (OH) and its anti-proliferative and antioxidant effects and found that OH significantly reduced nitric oxide production by lipopolysaccharide activated RAW 264.7 cells (p<0.001). Our data show that the ethanolic extract of OH has anti-proliferative on several cancer cell lines, and has strong antioxidant activity, according to "In vitro anti-proliferative and antioxidant studies on Devil's Club Oplopanax horridus" by Tai J, Cheung S, Cheah S, Chan E, Hasman D.(3)

4. Ovarian cancer
In the study of 70% ethanol, 100% ethanol, and ethyl acetate extracts of OH and its potential proliferation of human ovarian cancer cell lines found that OH extract with cisplatin and paclitaxel enhanced its anti-proliferation IC(50) on A2780 and A2780CP70 cells. Cell cycle analysis demonstrated that the effect of OH extract on cell cycle was dependent on the concentration tested, blocking cells in the S and G2/M phases. At low concentrations it induced cell death by apoptosis, while at high concentrations, it kills cells by necrosis, according to "Inhibition of human ovarian cancer cell lines by devil's club Oplopanax horridus" by Tai J, Cheung S, Chan E, Hasman D.(4)

5. Colorectal cancer
in the observation of inhibitive effects of Oplopanax horridus extract (OhE) and its fractions (OhF1, OhF2, OhF3, OhF4 and OhF5) on the growth of human colorectal cancer cells found that OhE had potential antiproliferative effects on human colorectal cancer cells, and the active components are enriched in the OhF4 and OhF5 fractions. The anticancer mechanism of OhE, OhF4 and OhF5 might be attributed to the induction of apoptosis and the regulation of cell cycle transition, according to "Effects of Oplopanax horridus on human colorectal cancer cells" by Li XL, Sun S, Du GJ, Qi LW, Williams S, Wang CZ, Yuan CS.(5)

6. Anti-tuberculosis
The crude extract of an Alaskan ethnobotanical plant, Oplopanax horridus and its Anti-tuberculosis effects found that among the entire polarity range, fractions with distribution constant between 0.44 and 0.81 showed the most synergistic enhancement with an increase in potency by 108% for the recombined fractions, according to "Counter-current chromatography based analysis of synergy in an anti-tuberculosis ethnobotanical" by Inui T, Wang Y, Deng S, Smith DC, Franzblau SG, Pauli GF.(6)

7. Antiviral effects
In the observation of One hundred methanolic plant extracts were screened for antiviral activity against seven viruses, including Devil's claw found that the inner bark extract of Oplopanax horridus partially inhibited this virus, according to the study of "Antiviral screening of British Columbian medicinal plants" by McCutcheon AR, Roberts TE, Gibbons E, Ellis SM, Babiuk LA, Hancock RE, Towers GH.(7)

8. Etc.

Side effects
1. Do not use Devil's claw in children, if you are pregnant or breast feeding with out consulting with related field specialist,
2. The herb may interact with certain medicine, if you are taking lower blood sugar medicine, please consult with your doctor before applying.
3. It may cause allergic reaction.
4. Etc.

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/9392889
(2) http://www.ncbi.nlm.nih.gov/pubmed/20723598
(3) http://www.ncbi.nlm.nih.gov/pubmed/16814500(4)http://www.ncbi.nlm.nih.gov/pubmed/19835944
(5) http://www.ncbi.nlm.nih.gov/pubmed/20332432
(6) http://www.ncbi.nlm.nih.gov/pubmed/17316661
(7) http://www.ncbi.nlm.nih.gov/pubmed/8847882

Most Common Disease of 50plus: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Polymyalgia Arthritis (Rheumatica): The Antioxidants

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed. A major restriction of joint movement range was frequent in the shoulder but uncommon in other joints(1).

Types of Musculo-Skeletal disorders in elder(2)
1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalgia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia

Polymyalgia Arthritis (Rheumatica)

Polymalgia Arthritis is defined as a condition a common inflammatory rheumatic disease which causes pain, stiffness and tenderness in large muscles, including muscles shoulders and pelvic girdle as a result of the presence of a synovitis in proximal joints and periarticular structures.

The Antioxidants

Free radicals are atoms, molecules, or ions with unpaired electrons through chemical bonds with other atoms or molecules during a chemical reaction. They may have positive, negative or zero charge.

1. Immune system and functioning (Free radical scavengers)
Free Radicals play an important role in the function of the Immune System. The immune system produces free radicals to kill foreign microbes(176, 127)(177,128), but the production of free radical sometime can be excessive, leading to formation of a large number of free radicals(178,129)(179,130). The domino effects have shown to induce many chronic illness, such as cancers(179,130).

a. Vitamin A
vitamin A plays an essential roles in enhancing a broad range of immune processes, including white blood cells activation and proliferation(180,132)of T-helper-cell differentiation, the production of specific antibody in regulation of the immune response(182,133).

b. Vitamin C
Due to recent promotion of western diet in some developed country, deficiencies of micronutrients are emerging as the limiting factors in ensuring children's optimal health, according Bayer Consumer Care Ltd(134). Deficiency of vitamin C and zinc in fact, interfere with normal children's growth and development(134). Researchers found that vitamin C raised the concentration in the blood of total immunoglobulin(183,135) in promotion of the ability of antibodies and phagocytic cells to clear pathogens(184,136).
c. Vitamin D
Deficiency of vitamin D is found to associate to nonspecific musculoskeletal pain. According to Maccabi Healthcare Services, improvement of levels of 25OHD reduced Polymyalgia pain induced by the use of statins(131).

c. Vitamin E
According to Dr. Moriguchi S and Dr. Muraga M., vitamin E plays an essential role in enhanced immunity especially in cellular immunity with aging(137). Deficiency of vitamin E is found to induces the decreased differentiation of immature T cells associated to the increased infectious diseases and the incidence of tumors(137)

d. Zinc
Zinc, having a regulatory role in the immune system, as a antioxidant is essential mineral improved immune system by enhancing the proper function of T and B cells(188,138) which belong to a group of white blood cells known as lymphocytes, in fighting against damaging free radicals(190,139).

2. Antioxidants and inflammation
Diet included vitamin E significantly reduce the levels of inflammation by analyzing the pro and anti-inflammatory cytokines in the blood serum(193,140).
a. Glucosamine and chondroitin
Glucosamine used for treatment of osteoporosis and prevent the degenerative collagen, has been found to consist anti-inflammatory properties through reduction of the expression of proinflammatory cytokines such as C-reactive protein (hsCRP), interleukin (IL)-1β, IL-6(141). The supplement also exhibited a significant reduction in pain intensity at movement and resting state, according to a Russian study(142).
b DLPA (dl- phenylalanine)
DLPA, a mixture of D-Phenylalanine and L-Phenylalanine, is a nutritional supplement amino acid(196,143). Taltirelin, a thyrotropin-releasing hormone analog, showed effectively to relieve inflammatory persistent pain through iots antiallodynic action(144).

c. Methylsulfonylmethane, also known DMSO2 is an organosulfur compound with the formula (CH3)2SO2 showed to exhibit anti inflammatory effects in attenuated production of mitochondrial reactive oxygen species (ROS)(145).
In a randomized, double-blind, placebo-controlled trial of Fifty men and women, 40-76 years of age MSM (3g twice a day) improved symptoms of pain and physical function during the short intervention without major adverse events, after 12 weeks(199,146)(200,147).

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

References
(177,128) Superoxide Anion and Its Functions(Beta Forces)
(178,129) Free radicals and antioxidants in normal physiological functions and human disease by Valko M1, Leibfritz D, Moncol J, Cronin MT, Mazur M, Telser J.(PubMed)
(179,130) Free radicals, metals and antioxidants in oxidative stress-induced cancer by Valko M1, Rhodes CJ, Moncol J, Izakovic M, Mazur M.(PubMed)

(131) Muscle pain and serum creatine kinase are not associated with low serum 25(OH) vitamin D levels in patients receiving statins by Kurnik D1, Hochman I, Vesterman-Landes J, Kenig T, Katzir I, Lomnicky Y, Halkin H, Loebstein R.
(180,132) Cellular immunity in osteoarthritis: novel concepts for an old disease by Liossis SN1, Tsokos GC.(PubMed)
(182,133) Free Radicals, Antioxidants in Disease and Health by Lien Ai Pham-Huy,1 Hua He,2 and Chuong Pham-Huy3(PMC)
(134) Essential role of vitamin C and zinc in child immunity and health by Maggini S1, Wenzlaff S, Hornig D.(PubMed)
(183,135) New insights into the mechanisms of polyphenols beyond antioxidant properties; lessons from the green tea polyphenol, epigallocatechin 3-gallate by Hae-Suk Kim,a Michael J. Quon,c and Jeong-a Kima,b(PMC)
(184,136) Green tea catechin, epigallocatechin-3-gallate (EGCG): mechanisms, perspectives and clinical applications by Singh BN1, Shankar S, Srivastava RK.(PubMed)
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(188,138) Green tea: a new option for the prevention or control of osteoarthritis by Katiyar SK, Raman C.(PubMed)
(190,139) Inflammatory cytokine concentrations are acutely increased by hyperglycemia in humans role of oxidative stress by K Esposito, F Nappo, R Marfella, G Giugliano, F Giugliano, M Ciotola(Circulation)
(193,140) Green tea polyphenol epigallocatechin 3-gallate in arthritis: progress and promise by Ahmed S1.(PubMed)
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(142) [A role of melatonin in the treatment of low back pain].[Article in Russian] by Kurganova YM, Danilov AB.(PubMed)
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Most common Diseases of 50plus: The Obesity' Research and Studies of Very-low-carbohydrate diet vs High-carbohydrate diet In Renal Function

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(a) http://www.blogger.com/post-create.g?blogID=3714065621840877985
(1) http://www.ncbi.nlm.nih.gov/pubmed/20338292

Most Common Diseases of 50plus: Diabetes - The Antioxidants

Diabetes is defined as a condition caused by insufficient insulin entering the bloodstream to regulate the glucose. It is either caused by cells in pancreas dying off or receptor sites clogged up by fat and cholesterol.

The Antioxidants

Free radicals are formed disproportionately in diabetes by glucose oxidation, nonenzymatic glycation of proteins, and the subsequent oxidative degradation of glycated proteins. Abnormally high levels of free radicals and the simultaneous decline of antioxidant defense mechanisms can lead to damage of cellular organelles and enzymes, increased lipid peroxidation, and development of insulin resistance. These consequences of oxidative stress can promote the development of complications of diabetes mellitus(63).
1. Vitamin E (Free radical scavenger)
According to the study of Vitamin E: function and metabolism, Vitamin E is the term for a group of tocopherols and tocotrienols, of which α-tocopherol has the highest biological activity(a), and is the most common in the North American diet.
In the study of twenty-eight rats rendered diabetic by streptozotocin injection and fed either with a diet with low (10 mg/kg of chow), medium (75 mg/kg of chow) or high amounts of vitamin E (1300 mg/kg of chow). Nine age-matched nondiabetic rats receiving 75 mg of vitamin E/kg chow served as controls, the results showed that 1) vitamin E has a potential to prevent partially hyperglycemia-induced endothelial dysfunction, 2) under in vivo conditions vitamin E deficiency enhanced diabetic endothelial dysfunction dramatically, and 3) positive effects of vitamin E may be attenuated with a longer disease duration(64).

2. Vitamin C (Free radical scavenger)
Vitamin C or L-ascorbic acid is a water-soluble vitamin needed for the growth and repair of tissues of the body. Epidemiological studies showed that diets high in fruits and vegetables are associated with lower risk of cardiovascular disease, stroke and cancer, and with increased longevity(65).
In the study of 84 patients with type 2 diabetes referred to Yazd Diabetes Research Center, Iran, were included in the study. They received randomly either 500 mg or 1000 mg daily of vitamin C for six weeks, found that daily consumption of 1000 mg supplementary vitamin C may be beneficial in decreasing blood glucose and lipids in patients with type 2 diabetes and thus reducing the risk of complications(66).

3. Vitamin D
Vitamin D is a membrane antioxidant: thus Vitamin D3 (cholecalciferol) and its active metabolite 1,25-dihydroxycholecalciferol and also Vitamin D2 (ergocalciferol) and 7-dehydrocholesterol (pro-Vitamin D3) all inhibited iron-dependent liposomal lipid peroxidation(66a). There is evidence supporting that vitamin D status is important to regulate some pathways related to type 2 diabetes development. Based on available clinical and epidemiological data, the positive effects of vitamin D seem to be primarily related to its action on insulin secretion and sensitivity and secondary to its action on inflammation, according to the study by São Paulo State University(66b). Other study linked vitamin D deficiency as a culprit to the development of Type I and II diabetes. According yo the study by Laboratory of Experimental Medicine and Endocrinology (LEGENDO), Catholic University of Leuven, vitamin D deficiency has been shown to impair insulin synthesis and secretion in humans and in animal models of diabetes, suggesting a role in the development of type 2 diabetes. Furthermore, epidemiological studies suggest a link between vitamin D deficiency in early life and the later onset of type 1 diabetes(66c).

4. Coenzyme Q10
Coenzyme Q10 (CoQ10) found naturally in the body is necessary for the basic functioning of cells. In the study to investigate the effects of coenzyme Q10 (CoQ10) treatment on insulin secretory response, hearing capacity and clinical symptoms of maternally inherited diabetes mellitus and deafness (MIDD), found that the insulin secretory response assessed by glucagon-induced C-peptide secretion and 24 h urinary C-peptide excretion after 3 years in the CoQ10-DM group was significantly higher than that in the control-DM group. CoQ10 therapy prevented progressive hearing loss and improved blood lactate after exercise in the MIDD patients. CoQ10 treatment did not affect the diabetic complications or other clinical symptoms of MIDD patients(67). Other study suggested that CoQ supplementation may improve blood pressure and long-term glycaemic control in subjects with type 2 diabetes, but these improvements were not associated with reduced oxidative stress, as assessed by F2-isoprostanes(68).

5. Alpha-lipoic acid
Alpha-lipoic acid, an antioxidant made by the body and is is necessary for the basic functioning of cells
to turn glucose into energy. According to the study of Bühl and City Hospital, Baden-Baden, Germany, alpha-lipoic acid (ALA), a naturally occuring compound and a radical scavenger was shown to enhance glucose transport and utilization in different experimental and animal models. Oral administration of alpha-lipoic acid can improve insulin sensitivity in patients with type-2 diabetes. The encouraging findings of this pilot trial need to be substantiated by further(69).

6. L-carnitine
L carnitines, is an antioxidant protected our body against lipid peroxidation and oxidative stress. Supplementation of L-carnitine and antioxidants improve lipid profiles and exercise ability in exercise-trained rats. Also, both exercise training and supplementation of carnitine and antioxidants improved lipid profiles and carnitine metabolism in humans, suggesting that carnitine and antioxidant supplementation may improve exercise performance, according to the study by Faculty of Medicine, University of British Columbia(70).

Most common Diseases of 50plus: Obesity and Obesity's complication of Type II diabetes

Diabetes is defined as a medical condition of insufficient insulin entering the bloodstream to regulate the glucose. It is either caused by cells in the pancreas dying off or receptor sites clogged up by the accumulation of fat and cholesterol. In some case, diabetes is also caused by allergy reactions of cells in our body.

How obesity cause type II diabetes
Type II diabetes is a result of insulin resistance and obesity is considered as a risk factor for developing insulin resistance.
1. According to the article of "Obesity and insulin resistance" by Barbara B. Kahn and Jeffrey S. Flier (1), researchers indicated that the association of obesity with type 2 diabetes has been recognized for decades, and the major basis for this link is the ability of obesity to engender insulin resistance. Insulin resistance is a fundamental aspect of the etiology of type 2 diabetes and is also linked to a wide array of other pathophysiologic sequelae including hypertension, hyperlipidemia, atherosclerosis (i.e., the metabolic syndrome, or syndrome X), and polycystic ovarian disease.

In conclusion, the author wrote that advances over the last decade have expanded our understanding of the role of adipocytes in biology, and this has begun to provide mechanistic insights into the causal relationship between obesity and diabetes. It is now clear that adipocytes function as endocrine glands with wide-reaching effects on other organs including the brain. The release of a wide variety of molecules including hormones such as leptin, cytokines such as TNF-α, and substrates such as FFAs allows the adipose organ to play a major regulatory role in energy balance and glucose homeostasis.

2. Adipogenesis
Some researchers suggested that adipogenesis may be the cause of obesity and insulin resistance due to preadipocytes become adipocytes ( lipocytes and fat cells)as a result of gene expression. According to the study of "Obesity, adipogenesis and insulin resistance." [Article in English, Spanish] by Ros Pérez M, Medina-Gómez G. (Source from Departamento de Bioquímica, Fisiología y Genética Molecular, Universidad Rey Juan Carlos, Facultad de Ciencias de la Salud, Alcorcón, Madrid, España.), posted in PubMed, researchers found that Obesity is considered as a risk factor for developing insulin resistance. Increased adipose tissue has been related to an increased production of pro-inflammatory cytokines which, together with fatty acids, appear to be responsible for the development of insulin resistance. Thus, a greater or lesser expansibility or ability of adipose tissue to store lipids also appears to play a significant role in the development of insulin resistance because overcoming of this capacity, which is variable in each case, would result in leaking of lipids to other tissues where they could interfere with insulin signaling.

3. Etc.

Treatments
1. Can Gene and Inherited factor cause of Obesity and type II diabetes be changed
Obesity and type II diabetes as a result of genetic susceptible or heredity can be prevented, according to the study of " Lifestyle and Genetics in Obesity and type 2 Diabetes." by Temelkova-Kurktschiev T, Stefanov T. (Source from Medicobiological Unit.) posted in PubMed, researchers found that gene-lifestyle interaction studies suggest that
a. Genetic susceptibility to obesity and type 2 diabetes may be partially or totally kept under control by healthy lifestyle or lifestyle modification and that lifestyle determines whether an individual is likely to develop the disease.
b. Inherited factors, however, seem to influence individual response to a lifestyle intervention program and even the motivation for lifestyle change. Personalized interventions according to genotype may be, therefore, considered in the future.
By then lifestyle modification targeting dietary change and increased physical activity may be recommended for successful obesity and type 2 diabetesprevention irrespectively of genetic susceptibility.

2. Leptin and Obesity and Type 2 Diabetes
Since leptin is the protein product of the obese gene, many researchers have tries to develop the mew approach to treat obesity and type 2 diabetes. In a study of "Novel Approaches to the Treatment of Obesity and Type 2 Diabetes Mellitus: Bioactive Leptin-Related Synthetic Peptide Analogs." by Grasso P. (Source from Department of Medicine, Division of Endocrinology and Metabolism Albany Medical College, MC 141, Albany, NY 12208, USA. grassop@mail.amc.edu), posted in PubMed, researches indicated that The pleiotropic nature of leptin has been confirmed by demonstration of a role for leptin in hematopoiesis, angiogenesis, immune function, osteogenesis, reproduction, and wound healing. Unfortunately, the results of the majority of clinical trials with recombinant human leptin indicated that its effectiveness in restoring energy balance and correcting obesity-related endocrinopathies in genetically obese rodent models extended only to the management of those rare forms of human obesity caused by mutation in the ob gene. Failure of leptin in the clinic, and withdrawal of fenfluramine, phentermine, and sibutrimine from clinical use in the United States, have stimulated new approaches in the development of anti-obesity and anti-diabetes pharmacophores.
Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer