Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Elecampane
Elecampane, also known as Horse-heal (Inula helenium) is a perennial composite plant, genus nula, belonging to Asteraceae, native to Southern Europe, andAsia. It has been used in traditional and herbal medicine in treating in bronchitis or emphysema, night sweats, pulmonary tuberculosis, irritating cough, catarrhal discharges, etc.
Health Benefits
1. Antioxidant response
In the evaluation of fractionated the methanolic extract and theirs detoxifying enzymes effect found that the highest QR-inducing activity and also induced glutathione S-transferase in a dose-dependent manner. Its potential to induce the reporter activity suggested an antioxidant response element-mediated mechanism of action in the induction of phase II detoxifying enzymes, according to the study of "Induction of detoxifying enzyme by sesquiterpenes present in Inula helenium" by Lim SS, Kim JR, Lim HA, Jang CH, Kim YK, Konishi T, Kim EJ, Park JH, Kim JS.(1)
2. Antiproliferative effects
In the investigation of components ginger and elecampane of Padma Laxand theirs effect on constipation found that PL exhibits antiproliferative properties which may be beneficial to prevent constipation-related cancer, according to the study of "Antiproliferative properties of Padma Lax and its components ginger andelecampane" by Hofbauer S, Kainz V, Golser L, Klappacher M, Kiesslich T, Heidegger W, Krammer B, Hermann A, Weiger TM.(2)
3. Prophet Job diseases
In the observation of Elecampane (Inula Campana) and it ani Prophet Job disease found that the herb relieves all kinds of pains, especially those arising from chills, and animal bites. In traditional medicine, Elecampane was and is still used in different forms for the cure of many diseases according to "Elecampane and Job's disease" by Al-Gammal SY.(3)
4. Antimycobacterial effects
In the evaluation of the root extracts of Elecampane (Inula helenium L.; Asteraceae) and Sweet Coneflower (Rudbeckia subtomentosa Pursh.; Asteraceae and their effects in Antimycobacterial eudesmanolides found that l. helenium, which exhibited significant activity against Mycobacterium tuberculosis, provided the known eudesmanolides alantolactone, isoalantolactone, and 11 alpha H, 13-dihydroisoalantolactone, according to "Antimycobacterial eudesmanolides from Inula helenium and Rudbeckia subtomentosa" by Cantrell CL, Abate L, Fronczek FR, Franzblau SG, Quijano L, Fischer NH.(4)
5. Relaxant effects
In the examination of the effects of volatile oils of 22 plants from 11 different families and of some of their constituents on tracheal and ileal smooth muscles found that in all of the oils had relaxant effects on the tracheal smooth muscle, the most potent were angelica root, clove, elecampane root, basil and balm leaves oil. 16 oils inhibited the phasic contractions of the ileal myenteric plexus-longitudinal muscle preparation, according to "Relaxant effects on tracheal and ileal smooth muscles of the guinea pig" by Reiter M, Brandt W.(5)
6. Anti-tumor activity
In the identification of botanical extracts with antineoplastic activity from Inulahelenium root and its effect found that the Inula helenium extract revealed a highly selective toxicity toward four different tumor cell lines (HT-29, MCF-7, Capan-2 and G1), but a much lower toxicity against healthy human peripheral blood lymphocytes (PBLs) from two donors, according to "Tumor cell specific toxicity of Inula helenium extracts" by Dorn DC, Alexenizer M, Hengstler JG, Dorn A.(6)
7. Cytostatic effect
In the affirmation of Biological activity of peptide extracts of medicinal plants, including Inula helenium L., found that thiers effect in non-small-cell lung carcinoma A549 cells, lung cancer H1299 cells, and cervical cancer HeLa cells, found that the cytostatic effect was produced by peptide extracts of Camelia sinesis Kuntze, Inonotus obliquus, and a mixture Inula helenium L., Chelidonium majus L., Equisetum arvense L., and Inonotus obliquus, according to "Cytostatic activity of peptide extracts of medicinal plants on transformed A549, H1299, and HeLa Cells" by Tepkeeva II, Aushev VN, Zborovskaya IB, Demushkin VP.(7)
8. Natural preservative system
In observation of development of a new natural preservative system containing both chitosan and I. helenium L. extract found that the patch test also showed that this preservative system reduced skin irritation by about 30-50%, as compared to the organic preservative system. Therefore, the good natural preservative system including chitosan and Inula helenium L. extract could be incorporated in cosmetic formulations according to "Development of a natural preservative system using the mixture of chitosan-Inula helenium L. extract" by Seo SB, Ryu CS, Ahn GW, Kim HB, Jo BK, Kim SH, Lee JD, Kajiuchi T.(8)
9. Skin cancer
in the study of Isocostunolide,a sesquiterpene lactone isolated from the roots ofInula helenium and its effect in cytotoxicity found that isolated and characterized isocostunolide from I. helenium. This compound induces apoptosis through a mitochondria-dependent pathway in A2058 cells, according to "Isocostunolide, a sesquiterpene lactone, induces mitochondrial membrane depolarization and caspase-dependent apoptosis in human melanoma cells" by Chen CN, Huang HH, Wu CL, Lin CP, Hsu JT, Hsieh HP, Chuang SE, Lai GM.(9)
10. Anti stress
In the evaluation of preparations from the underground part of elfwort (Inulahelenium) and its antistressor and antioxidant properties found that The preparations produced a protective effect with respect to internal organs, blood, carbohydrate metabolism, and lipid peroxidation process, according to "[Mechanisms of antistressor activity of Inula helenium preparations].[Article in Russian]" by Nesterova IuV, Zelenskaia KL, Vetoshkina TV, Aksinenko SG, Gorbacheva AV, Gorbatykh NA.(10)
11. Etc.
Side effects
1. Elecampane may cause allergic effect, according to "Contact allergy and medicinal herbs.[Article in English, German]" by Aberer W.(a)
2. Do not use the herb if you are pregnant or breast feeding without approval of related field specialist
3. Do not use elecampane in children
4. Etc.
Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/17887945
(2) http://www.ncbi.nlm.nih.gov/pubmed/16582559
(3) http://www.ncbi.nlm.nih.gov/pubmed/12587579
(4) http://www.ncbi.nlm.nih.gov/pubmed/10364842
(5) http://www.ncbi.nlm.nih.gov/pubmed/4039178
(6) http://www.ncbi.nlm.nih.gov/pubmed/16912983
(7) http://www.ncbi.nlm.nih.gov/pubmed/19526129
(8) http://www.ncbi.nlm.nih.gov/pubmed/18498511
(9) http://www.ncbi.nlm.nih.gov/pubmed/16697106
(10) http://www.ncbi.nlm.nih.gov/pubmed/14558358
(a) http://www.ncbi.nlm.nih.gov/pubmed/17919303
Tuesday, May 31, 2016
Traditional Chinese Medicine Herbal Therapy - Popular Herbal Chinese Herbs – Bai Jie Zi (Semen Sinapis Albae)
Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Bai Je Zi
Bai Je Zi is also known as white mustard seed, the warm, acrid and toxic herb has been used in TCM to treat cough, asthmatic, pain in limbs and joints, migrating sores, emphysema, leaching pleurisy, neuralgia, etc., as it warms the Lungs, eliminates Phlegm, moves Qi, disperses nodules Promotes circulation in the channels by enhancing the functions of lung and stomach channels.
Health Benefits
1. Liver cancer
Glucoraphasatin and myrosinase were isolated and purified from Daikon sprouts and Sinapis alba L, has demonstrated the activity as a potent inducer of hepatic enzymes involved in the detoxification of chemical carcinogens, according to the study of “4-Methylsulfanyl-3-butenyl isothiocyanate derived from glucoraphasatin is a potent inducer of rat hepatic phase II enzymes and a potential chemopreventive agent” by Abdull Razis AF, De Nicola GR, Pagnotta E, Iori R, Ioannides C.(1).
2. Antioxidants
Bai Jie Zi (Mustard Seed) has decreased plasma levels of the lipid peroxidation product malonaldehyde in mice exposed to the colon cancer-inducer azoxymethane (AOM) and reduced formation of colon adenomas by about 50%, according to the study of “Mustard seeds (Sinapis Alba Linn) attenuate azoxymethane-induced colon carcinogenesis” by Yuan H, Zhu M, Guo W, Jin L, Chen W, Brunk UT, Zhao M(2).
3. Asthma
Plasters made up of Gansui (Radix Euphorbiae Kansui), Baijiezi (Semen Sinapis Albae), Mahuang (Herba Ephedrae), Xixin (Herba Asari), etc. were applied to Feishu (BL 13), Fengmen (BL 12), Dingchuan (EX-B 1), Pishu (BL 20) Shenshu (BL 23), etc. has exerted the effectively improve asthma patients’ clinical symptoms, lower serum IgE and Eos count and raise LTR, according to the study of”[A study on the time-effect relationship in the treatment of bronchial asthma with medicinal vesiculation therapy]. [Article in Chinese]” by Zhuang LX, Zhao MH, Yang JJ, Deng QP.(3).
4. Calcium-rich drinks
A calcium-soluble protein isolate (CSPI) was prepared from the supernatant obtained after addition of 0.75 M calcium chloride to a pH 5.0 aqueous extract of yellow mustard (Sinapis alba) seed meal may be the next generation used to prepare calcium-fortified high protein liquid products, according to the study of “Characterization of a calcium-soluble protein fraction from yellow mustard (Sinapis alba) seed meal with potential application as an additive to calcium-rich drinks” by Aluko RE, Reaney M, McIntosh T, Ouellet F, Katepa-Mupondwa F.(4).
5. Prostatic hyperplasia
Sinalbin and beta-sitosterol separated from seeds of Brassica alba (Bai JIe Zi) significantly inhibit mice prostatic hyperplasia induced by testosterone propionate and activity of serum acid phosphatase, according to the study of “[An experimental study(II) on the inhibition of prostatic hyperplasia by extract of seeds of Brassica alba][Article in Chinese]” by Wu GX, Lin YX, Ou MR, Tan DF.(5).
6. Etc.
Side Effects
1. Allergic effects or occupational allergen as a result of the presence of predominant allergenic protein Sin a 1, according to the study of “Quantitative detection of allergenic protein Sin a 1 from yellow mustard (Sinapis alba L.) seeds using enzyme-linked immunosorbent assay” by Shim YY, Wanasundara JP(a)
2. External use in a prolonged period can cause inflammation
3. Do not use the herb, if you are pregnant or breast feeding without consulting with the related field specialist.
4. Etc.
Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/21960141
(2) http://www.ncbi.nlm.nih.gov/pubmed/21605497
(3) http://www.ncbi.nlm.nih.gov/pubmed/17580442
(4) http://www.ncbi.nlm.nih.gov/pubmed/15366859
(5) http://www.ncbi.nlm.nih.gov/pubmed/15139111 (a)http://www.ncbi.nlm.nih.gov/pubmed/18217709
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Bai Je Zi
Bai Je Zi is also known as white mustard seed, the warm, acrid and toxic herb has been used in TCM to treat cough, asthmatic, pain in limbs and joints, migrating sores, emphysema, leaching pleurisy, neuralgia, etc., as it warms the Lungs, eliminates Phlegm, moves Qi, disperses nodules Promotes circulation in the channels by enhancing the functions of lung and stomach channels.
Ingredients
1. Sinalbin
2.Myrosin
3. Sinapine
4. 4-hydroxybenzoylcholine
5. 4-hydroxybenzylamine
6. Glucosinalbin
7. Sinapinrhodanide
8. Fatty acid
9. Polysaccharides
10. Etc.
1. Sinalbin
2.Myrosin
3. Sinapine
4. 4-hydroxybenzoylcholine
5. 4-hydroxybenzylamine
6. Glucosinalbin
7. Sinapinrhodanide
8. Fatty acid
9. Polysaccharides
10. Etc.
Health Benefits
1. Liver cancer
Glucoraphasatin and myrosinase were isolated and purified from Daikon sprouts and Sinapis alba L, has demonstrated the activity as a potent inducer of hepatic enzymes involved in the detoxification of chemical carcinogens, according to the study of “4-Methylsulfanyl-3-butenyl isothiocyanate derived from glucoraphasatin is a potent inducer of rat hepatic phase II enzymes and a potential chemopreventive agent” by Abdull Razis AF, De Nicola GR, Pagnotta E, Iori R, Ioannides C.(1).
2. Antioxidants
Bai Jie Zi (Mustard Seed) has decreased plasma levels of the lipid peroxidation product malonaldehyde in mice exposed to the colon cancer-inducer azoxymethane (AOM) and reduced formation of colon adenomas by about 50%, according to the study of “Mustard seeds (Sinapis Alba Linn) attenuate azoxymethane-induced colon carcinogenesis” by Yuan H, Zhu M, Guo W, Jin L, Chen W, Brunk UT, Zhao M(2).
3. Asthma
Plasters made up of Gansui (Radix Euphorbiae Kansui), Baijiezi (Semen Sinapis Albae), Mahuang (Herba Ephedrae), Xixin (Herba Asari), etc. were applied to Feishu (BL 13), Fengmen (BL 12), Dingchuan (EX-B 1), Pishu (BL 20) Shenshu (BL 23), etc. has exerted the effectively improve asthma patients’ clinical symptoms, lower serum IgE and Eos count and raise LTR, according to the study of”[A study on the time-effect relationship in the treatment of bronchial asthma with medicinal vesiculation therapy]. [Article in Chinese]” by Zhuang LX, Zhao MH, Yang JJ, Deng QP.(3).
4. Calcium-rich drinks
A calcium-soluble protein isolate (CSPI) was prepared from the supernatant obtained after addition of 0.75 M calcium chloride to a pH 5.0 aqueous extract of yellow mustard (Sinapis alba) seed meal may be the next generation used to prepare calcium-fortified high protein liquid products, according to the study of “Characterization of a calcium-soluble protein fraction from yellow mustard (Sinapis alba) seed meal with potential application as an additive to calcium-rich drinks” by Aluko RE, Reaney M, McIntosh T, Ouellet F, Katepa-Mupondwa F.(4).
5. Prostatic hyperplasia
Sinalbin and beta-sitosterol separated from seeds of Brassica alba (Bai JIe Zi) significantly inhibit mice prostatic hyperplasia induced by testosterone propionate and activity of serum acid phosphatase, according to the study of “[An experimental study(II) on the inhibition of prostatic hyperplasia by extract of seeds of Brassica alba][Article in Chinese]” by Wu GX, Lin YX, Ou MR, Tan DF.(5).
6. Etc.
Side Effects
1. Allergic effects or occupational allergen as a result of the presence of predominant allergenic protein Sin a 1, according to the study of “Quantitative detection of allergenic protein Sin a 1 from yellow mustard (Sinapis alba L.) seeds using enzyme-linked immunosorbent assay” by Shim YY, Wanasundara JP(a)
2. External use in a prolonged period can cause inflammation
3. Do not use the herb, if you are pregnant or breast feeding without consulting with the related field specialist.
4. Etc.
Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/21960141
(2) http://www.ncbi.nlm.nih.gov/pubmed/21605497
(3) http://www.ncbi.nlm.nih.gov/pubmed/17580442
(4) http://www.ncbi.nlm.nih.gov/pubmed/15366859
(5) http://www.ncbi.nlm.nih.gov/pubmed/15139111 (a)http://www.ncbi.nlm.nih.gov/pubmed/18217709
Most common Diseases of 50plus: The Obesity' Research and Studies of Dietary carbohydrate and fat and diabetes
Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Obesity is a medical condition of excess body fat accumulated overtime, while overweight is a condition of excess body weight relatively to the height. According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered over weight, while a BMI of over 30 is an indication of obesity. According to the statistic, 68% of American population are either overweight or obese.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Obesity is a medical condition of excess body fat accumulated overtime, while overweight is a condition of excess body weight relatively to the height. According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered over weight, while a BMI of over 30 is an indication of obesity. According to the statistic, 68% of American population are either overweight or obese.
You can calculate your BMI index BMI= weight (kg)/ height (m2)
The Research and Studies of Dietary carbohydrate and fat and diabetes
The Research and Studies of Dietary carbohydrate and fat and diabetes
In the review of the emphasis in recent years has been on the reduction of total fat and saturated fat and replacement with complex carbohydrate. Scientist from the Stanford University School of Medicine(1) indicated that there is little evidence to support the notion that low-fat high-carbohydrate diets per se lead to any reduction in the risk for CAD in individuals with diabetes from the available data, but the only data indicating that low-fat high-carbohydrate diets lead to beneficial effects on carbohydrate and lipoprotein metabolism are confounded either by the lack of suitable experimental control. The group said that diets also differed in the type of dietary fat and amount of dietary cholesterol, or were enormously enriched in dietary fiber. When these factors are taken into consideration, there appears to be little evidence in support of the view that substituting carbohydrate for fat in the diets of individuals with diabetes results in any measurable beneficial effect.
The group continued that indeed, it could be argued that the most characteristic defects in carbohydrate and lipoprotein metabolism are exacerbated in response to low-fat high-carbohydrate diets. Alternatively, the data presented herein strongly suggest that diets containing conventional quantities of fat, in which saturated fat is replaced by unsaturated fat and dietary cholesterol reduced, would result in the desired reductions to total and low-density lipoprotein cholesterol concentrations without the adverse effects of increased postprandial glucose and insulin concentrations, increased fasting and postprandial total and very-low-density lipoprotein triglyceride concentrations, and decreased fasting high-density lipoprotein cholesterol concentrations.
Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
(1) "Effects of dietary carbohydrate and fat intake on glucose and lipoprotein metabolism in individuals with diabetes mellitus" by Hollenbeck CB, Coulston AM., posted in PubMed
The group continued that indeed, it could be argued that the most characteristic defects in carbohydrate and lipoprotein metabolism are exacerbated in response to low-fat high-carbohydrate diets. Alternatively, the data presented herein strongly suggest that diets containing conventional quantities of fat, in which saturated fat is replaced by unsaturated fat and dietary cholesterol reduced, would result in the desired reductions to total and low-density lipoprotein cholesterol concentrations without the adverse effects of increased postprandial glucose and insulin concentrations, increased fasting and postprandial total and very-low-density lipoprotein triglyceride concentrations, and decreased fasting high-density lipoprotein cholesterol concentrations.
Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
(1) "Effects of dietary carbohydrate and fat intake on glucose and lipoprotein metabolism in individuals with diabetes mellitus" by Hollenbeck CB, Coulston AM., posted in PubMed
Most common Diseases Free and Longevity of 50 plus - Organic Soy Part A By Healthy Foods Soy Sauce
Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Over the years of research, 4 foods appeared mostly in medical studies in preventing and treating diseases, are Green Tea, Grape seed and skin, Turmeric and Organic Soy(Not for Western Women). All Right Reserved.
IV. Organic Soy
Soy foods, including tofu have been in traditional Chinese diet over thousands of year, according to Chinese literature. The reduced risk of chronic disease in Asian population, including metabolic syndrome such as cardiovascular diseases, obesity and diabetes and lesser menopause symptoms in advanced age, may be aided by eating a lot of soy food accompanied with large portion of vegetables and fruits. Indeed, according to the study, only 10% of women in the East are experience symptoms of menopause in advanced age compared to over 70% of their Western counterparts.
According to Dr. Mark Messina, Ph.D., Soy foods contributed from 6.5%8 to 12.8%7 of total protein intake in older adult in Japan.(b)
The approval of cardiovascular benefit of soy by FDA in 1999 accompanied with the discovery of health benefits in clinical studies over past decade, prompted the promotion and advertisement of soy's health benefits in every aspect in Western society. Evidences could be seen by walking through the supermarkets and drug stores. Soy supplements and products such as tofu, soy milk, soy-based infant formula, and meatless “texturized vegetable protein” burgers were widely available. According to the United Soybean Board’s 2004–2005, 25% of Americans consumed soy foods or beverages at least once per week, and 74% viewed soy products as healthy.
Today, the promotion of soy is no longer existed, it may be results of discovery of adverse effects in single ingredient and animal studies, as intake of soy is associated to induce risk of certain mammary cancers and infertility. The publication of the result have drawn many criticisms. According to Thomas Badger, director and senior investigator at the Arkansas Children’s Nutrition Center in Little Rock, these effects are seen only under certain experimental conditions that are not likely to occur in humans—and therein lies the crux of the debate(a).Equol (4',7-isoflavandiol), an isoflavandiol metabolized from daidzein may be the causes, as 90% of Eastern population are equol producers but only 30% in the West.
The explanation of the positive effect of soy isoflavones in reduced risk of mammary cancers by University of Goettingen may be interesting, as researchers said" Most importantly, there is dispute as to whether isoflavones derived from soyor red clover have negative, positive or any effect at all on the mammary gland or endometrium. It is beyond any doubt that soy products may have cancerpreventing properties in a variety of organs including the mammary gland. However, these properties may only be exerted if the developing organ was under the influence of isoflavones during childhood and puberty".
Soy sauce
Soy sauce is a seasoning produced by fermenting soybeans and filamentous fungus, along with water and salt after a period of sometime, it yields a moromi or thick mash of cereal to obtain soy sauce by pressing it to liquid form. Tamari is made by collecting the liquid which was pressed and the liquid drained drains from miso after a certain time of fermentation.
Nutrients
1. Sodium
2. protein
3. Fat
4. Niacin (Vitamin B3)
5. Iron
6. Manganese
7. Magnesium
7. Phosphorus
8. Riboflavin
9. Vitamin B6
10. Isoflavones
11. Etc
I. Health benefits by Healthy Food Soy Sauce
Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Sources
(a) http://www.ncbi.nlm.nih.gov/pubmed/22139566
(b) http://www.ncbi.nlm.nih.gov/pubmed/19240374
(c) http://www.ncbi.nlm.nih.gov/pubmed/15492861
(d) http://www.ncbi.nlm.nih.gov/pubmed?term=Shoyu%20and%20breast%20cancer
(e) http://www.ncbi.nlm.nih.gov/pubmed/18813866
(1) http://www.ncbi.nlm.nih.gov/pubmed/19539268
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
IV. Organic Soy
Soy foods, including tofu have been in traditional Chinese diet over thousands of year, according to Chinese literature. The reduced risk of chronic disease in Asian population, including metabolic syndrome such as cardiovascular diseases, obesity and diabetes and lesser menopause symptoms in advanced age, may be aided by eating a lot of soy food accompanied with large portion of vegetables and fruits. Indeed, according to the study, only 10% of women in the East are experience symptoms of menopause in advanced age compared to over 70% of their Western counterparts.
According to Dr. Mark Messina, Ph.D., Soy foods contributed from 6.5%8 to 12.8%7 of total protein intake in older adult in Japan.(b)
The approval of cardiovascular benefit of soy by FDA in 1999 accompanied with the discovery of health benefits in clinical studies over past decade, prompted the promotion and advertisement of soy's health benefits in every aspect in Western society. Evidences could be seen by walking through the supermarkets and drug stores. Soy supplements and products such as tofu, soy milk, soy-based infant formula, and meatless “texturized vegetable protein” burgers were widely available. According to the United Soybean Board’s 2004–2005, 25% of Americans consumed soy foods or beverages at least once per week, and 74% viewed soy products as healthy.
Today, the promotion of soy is no longer existed, it may be results of discovery of adverse effects in single ingredient and animal studies, as intake of soy is associated to induce risk of certain mammary cancers and infertility. The publication of the result have drawn many criticisms. According to Thomas Badger, director and senior investigator at the Arkansas Children’s Nutrition Center in Little Rock, these effects are seen only under certain experimental conditions that are not likely to occur in humans—and therein lies the crux of the debate(a).Equol (4',7-isoflavandiol), an isoflavandiol metabolized from daidzein may be the causes, as 90% of Eastern population are equol producers but only 30% in the West.
The explanation of the positive effect of soy isoflavones in reduced risk of mammary cancers by University of Goettingen may be interesting, as researchers said" Most importantly, there is dispute as to whether isoflavones derived from soyor red clover have negative, positive or any effect at all on the mammary gland or endometrium. It is beyond any doubt that soy products may have cancerpreventing properties in a variety of organs including the mammary gland. However, these properties may only be exerted if the developing organ was under the influence of isoflavones during childhood and puberty".
Soybean is genus Glycine, the family Fabaceae, one of the legumes that contains twice as much protein per acre as any other major vegetable or grain crop, native to Southeast Asia. Now, it is grown worldwide with suitable climate for commercial profit and a a healthy foods.
Soy sauce is a seasoning produced by fermenting soybeans and filamentous fungus, along with water and salt after a period of sometime, it yields a moromi or thick mash of cereal to obtain soy sauce by pressing it to liquid form. Tamari is made by collecting the liquid which was pressed and the liquid drained drains from miso after a certain time of fermentation.
Nutrients
1. Sodium
2. protein
3. Fat
4. Niacin (Vitamin B3)
5. Iron
6. Manganese
7. Magnesium
7. Phosphorus
8. Riboflavin
9. Vitamin B6
10. Isoflavones
11. Etc
I. Health benefits by Healthy Food Soy Sauce
A. Health benefits according to studies
1. Cardiovascular health
In the investigation of dietary proteins and their effect in heart diseases found that a direct cholesterol lowering effect of proteins has not been shown. Despite earlier research indicating that soy protein has cardioprotective effects as compared to other proteins, these observations have not been confirmed by randomized placebo-controlled trials. However, most experts recommend the consumption offoods rich in plant proteins as alternatives to meat and dairy products rich in saturated fat and containing cholesterol, according to "Dietary proteins and atherosclerosis" by Darioli R.(a)
2. Perennial allergic rhinitis (PAR)
In the study of isolated a halophilic lactic acid bacterium, Tetragenococcus halophilus Th221, from soy sauce moromi and the its effect on serum total immunoglobulin E, found that The change in serum total immunoglobulin E improved significantly at the end of the trial compared with the beginning in this group (p < 0.05). The safety of Th221 treatment was confirmed by laboratory tests and inspection of the general condition of each subject and concluded that Th221 can be expected to safely improve the symptoms of PAR, according to "Clinical efficacy of halophilic lactic acid bacterium Tetragenococcus halophilus Th221 from soy sauce moromi for perennial allergic rhinitis" by Nishimura I, Igarashi T, Enomoto T, Dake Y, Okuno Y, Obata A.(b)
3. Anti-allergic activities
In the assessment of oral supplementation of Shoyu polysaccharides (SPS) and its effective intervention for patients with perennial allergic rhinitis found that evaluation of the medication's effectiveness after 4 weeks treatment showed significant differences between the SPS- and placebo-treated groups (p<0.05). In conclusion, SPS of soy sauce improved the quality of life for patients with perennial allergic rhinitis, and soy sauce would be useful in an anti-allergic therapy utilizing everyday foods, according to "Quality of life improvement with soy sauce ingredients, Shoyu polysaccharides, in perennial allergic rhinitis: a double-blind placebo-controlled clinical study" by Kobayashi M, Matsushita H, Shioya I, Nagai M, Tsukiyama R, Saito M, Sugita T, Sugimura T, Yamamoto K.(c)
4. Breast cancer
In the analyzing of Shoyu and on the gastric mucosa of the rat found that the animals given shoyu were smaller than the controls; 15 intact rats receiving the sauce were healthy at 33 months compared with 7 controls. Only 9 of 50 operated rats lived 33 months. Breast tumors developed in 10 control rats but in none givenshoyu. The distribution of other tumors was the same,... and concluded that Shoyudid not appear to be a carcinogen in the rat; its prolonged use impaired neither health nor longevity. Long-term use was associated with gastric mucus loss and nuclear changes in a few rats, occasionally with a mild gastritis. according to "Long-term effect of shoyu (Japanese soy sauce) on the gastric mucosa of the rat" by MacDonald WC, Dueck JW.(4)
5. Hypolipidemic effect
In the observation of Soy sauce (Shoyu), a traditional Japanese fermented seasoning and its effect on cholesterol level found that in a 4-week randomized, double-blind, placebo-controlled parallel group study, hyperlipidemic men (TG >150 mg/dl) were treated with 600 mg of SPS (n=15) or placebo (n=15) daily. After 4 weeks, serum TG levels in the SPS-treated group were significantly (P<0.05) lower than the baseline (0 week). In conclusion, SPS of soy sauce reduce lipid absorption, and soy sauce is a potentially promising seasoning for the treatment of hyperlipidemia through food, according to "Hypolipidemic effect of Shoyupolysaccharides from soy sauce in animals and humans" by Kobayashi M, Magishi N, Matsushita H, Hashimoto T, Fujimoto M, Suzuki M, Tsuji K, Saito M, Inoue E, Yoshikawa Y, Matsuura T.(e)
6. Etc.
B. Health benefits according to concentration
1. Tryptophan
Tryptophan is one of the 10 essential amino acids which the body uses to synthesize the proteins for brain cells need, thus enhancing the nerve cells in information transmitting between themselves and cells in the parts of the body that reduces the risk of anxiety and depression, according to the study of "The effects of tryptophan depletion on neural responses to emotional words in remitted depression" by Roiser JP, Levy J, Fromm SJ, Nugent AC, Talagala SL, Hasler G, Henn FA, Sahakian BJ, Drevets WC.(1)
2. Manganese
Manganese beside plays an vital role for the proper and normal growth of human bone structure (accodring to the study of "Bone formation within alumina tubes: effect of calcium, manganese, and chromium dopants" by Pabbruwe MB,Standard OC, Sorrell CC, Howlett CR., posted in PubMed (http://www.ncbi.nlm.nih.gov/pubmed/15109850)), it also helps to reduce the risk of cancer, (according to the study of "The effects of 3, 4 or 5 amino salicylic acids onmanganese-induced neuronal death: ER stress and mitochondrial complexes" by Yoon H, Lee GH, Kim DS, Kim KW, Kim HR, Chae HJ., posted in PubMed (http://www.ncbi.nlm.nih.gov/pubmed/21477646 researchers indicated that the salicylate analogues and the antioxidants did not mediate ER stress in this model. The salicylate analogues reduced reactive oxygen species (ROS) and reversed the deficient mitochondrial membrane potential that was induced by Mn. Taken together, the 3, 4, 5 ASA worked in a similar way, regulating the Mn-induced mitochondrial dysfunction and protecting cells.
3. Protein
Protein beside is important building block of bones, muscles, cartilage, skin, and blood, it also enhances the nervous system in information transmitting between cells and cells of the other parts of the body, thus reducing the risk of nervous tension, (according to the study of "The planar polarity protein Scribble1 is essential for neuronal plasticity and brain function" by Moreau MM, Piguel N, Papouin T, Koehl M, Durand CM, Rubio ME, Loll F, Richard EM, Mazzocco C, Racca C, Oliet SH, Abrous DN, Montcouquiol M, Sans N, posted in PubMed (http://www.ncbi.nlm.nih.gov/pubmed/20660256)
4. Niacin or vitamin B3
Niacin or vitamin B3 beside is important in production of energy in metabolism of carbohydrate, it also essential for DNA repairing, according to the study of `Niacindeficiency delays DNA excision repair and increases spontaneous and nitrosourea-induced chromosomal instability in rat bone marrow`by Kostecki LM, Thomas M, Linford G, Lizotte M, Toxopeus L, Bartleman AP, Kirkland JB., posted in PubMed (http://www.ncbi.nlm.nih.gov/pubmed/17618655), production of steroid hormones in the adrenal gland, improving blood circulation and lowering the bad cholesterol (LDL) levels., according to the study of `Lowering LDL cholesterol with margarine containing plant stanol/sterol esters: is it still relevant in 2011?`by Doggrell SA., posted in PubMed (http://www.ncbi.nlm.nih.gov/pubmed/21296266)
5. Etc.
C. Other health benefits
Since soy sauce contains high amount of sodium, a trace mineral is classified as a cause of heart diseases and stroke if eating in high amount. In fact with correct amount, soy sauce not only helps to replace the daily intake of sodium but also enhances health benefits
1. Cholesterol
Certain studies found that certain types of soy sauce (popular in Chinese cookery) have been shown to reduce the levels of bad cholesterol (LDL) because of the existence of large amounts of the isoflavones, so choose your soy sauce wisely, according to the study of `Soy isoflavones lower serum total and LDL cholesterolin humans: a meta-analysis of 11 randomized controlled trials`by Taku K, Umegaki K, Sato Y, Taki Y, Endoh K, Watanabe S., posted in PubMed (http://www.ncbi.nlm.nih.gov/pubmed/17413118)
2. Isoflavones
Isoflavones is one of the weak estrogen that can compete with estrogen for the same receptor sites, as it decreasing the health risks of excess estrogen, promoting healthy menstrual cycle and reducing the risk of cancers caused by high levels of strong estrogen., according to the study of `Red clover and soyisoflavones-an in vitro safety assessment`by Reiter E, Gerster P, Jungbauer A., posted in PubMed (http://www.ncbi.nlm.nih.gov/pubmed/21801124), researchers wrote that
Isoflavones and plant extracts significantly reduced the proliferation activity of the treated cancer cell lines.
3. Riboflavin
Riboflavin or vitamin B2 besides is important for the production of energy in the metabolism of fats, carbohydrates, and proteins due to its coenzymes, flavin adenine dinucleotide and Flavin mononucleotide properties, it also is the best of natural element for treating migraines and muscle pain reliever used together with magnesium, according to the study of `Effectiveness of high-dose riboflavin inmigraine prophylaxis. A randomized controlled trial`by Schoenen J, Jacquy J, Lenaerts M., posted in PubMed (http://www.ncbi.nlm.nih.gov/pubmed/9484373)
4. Magnesium
Magnesium beside helps to maintain the right ratio with calcium, thus aiding the digestive system in absorption of calcium, according to the study of `Associations of calcium and magnesium in serum and hair with bone mineral density in premenopausal women`by Song CH, Barrett-Connor E, Chung JH, Kim SH, Kim KS., posted in PubMed (http://www.ncbi.nlm.nih.gov/pubmed/17848724) it also reduces the risk of irregular heart beat and impairs glucose tolerance, according to the study of `Dietary magnesium deficiency induces heart rhythm changes, impairs glucose tolerance, and decreases serum cholesterol in post menopausal women`by Nielsen FH, Milne DB, Klevay LM, Gallagher S, Johnson L., posted in PubMed (http://www.ncbi.nlm.nih.gov/pubmed/17536123)
5. Etc.
1. Cardiovascular health
In the investigation of dietary proteins and their effect in heart diseases found that a direct cholesterol lowering effect of proteins has not been shown. Despite earlier research indicating that soy protein has cardioprotective effects as compared to other proteins, these observations have not been confirmed by randomized placebo-controlled trials. However, most experts recommend the consumption offoods rich in plant proteins as alternatives to meat and dairy products rich in saturated fat and containing cholesterol, according to "Dietary proteins and atherosclerosis" by Darioli R.(a)
2. Perennial allergic rhinitis (PAR)
In the study of isolated a halophilic lactic acid bacterium, Tetragenococcus halophilus Th221, from soy sauce moromi and the its effect on serum total immunoglobulin E, found that The change in serum total immunoglobulin E improved significantly at the end of the trial compared with the beginning in this group (p < 0.05). The safety of Th221 treatment was confirmed by laboratory tests and inspection of the general condition of each subject and concluded that Th221 can be expected to safely improve the symptoms of PAR, according to "Clinical efficacy of halophilic lactic acid bacterium Tetragenococcus halophilus Th221 from soy sauce moromi for perennial allergic rhinitis" by Nishimura I, Igarashi T, Enomoto T, Dake Y, Okuno Y, Obata A.(b)
3. Anti-allergic activities
In the assessment of oral supplementation of Shoyu polysaccharides (SPS) and its effective intervention for patients with perennial allergic rhinitis found that evaluation of the medication's effectiveness after 4 weeks treatment showed significant differences between the SPS- and placebo-treated groups (p<0.05). In conclusion, SPS of soy sauce improved the quality of life for patients with perennial allergic rhinitis, and soy sauce would be useful in an anti-allergic therapy utilizing everyday foods, according to "Quality of life improvement with soy sauce ingredients, Shoyu polysaccharides, in perennial allergic rhinitis: a double-blind placebo-controlled clinical study" by Kobayashi M, Matsushita H, Shioya I, Nagai M, Tsukiyama R, Saito M, Sugita T, Sugimura T, Yamamoto K.(c)
4. Breast cancer
In the analyzing of Shoyu and on the gastric mucosa of the rat found that the animals given shoyu were smaller than the controls; 15 intact rats receiving the sauce were healthy at 33 months compared with 7 controls. Only 9 of 50 operated rats lived 33 months. Breast tumors developed in 10 control rats but in none givenshoyu. The distribution of other tumors was the same,... and concluded that Shoyudid not appear to be a carcinogen in the rat; its prolonged use impaired neither health nor longevity. Long-term use was associated with gastric mucus loss and nuclear changes in a few rats, occasionally with a mild gastritis. according to "Long-term effect of shoyu (Japanese soy sauce) on the gastric mucosa of the rat" by MacDonald WC, Dueck JW.(4)
5. Hypolipidemic effect
In the observation of Soy sauce (Shoyu), a traditional Japanese fermented seasoning and its effect on cholesterol level found that in a 4-week randomized, double-blind, placebo-controlled parallel group study, hyperlipidemic men (TG >150 mg/dl) were treated with 600 mg of SPS (n=15) or placebo (n=15) daily. After 4 weeks, serum TG levels in the SPS-treated group were significantly (P<0.05) lower than the baseline (0 week). In conclusion, SPS of soy sauce reduce lipid absorption, and soy sauce is a potentially promising seasoning for the treatment of hyperlipidemia through food, according to "Hypolipidemic effect of Shoyupolysaccharides from soy sauce in animals and humans" by Kobayashi M, Magishi N, Matsushita H, Hashimoto T, Fujimoto M, Suzuki M, Tsuji K, Saito M, Inoue E, Yoshikawa Y, Matsuura T.(e)
6. Etc.
B. Health benefits according to concentration
1. Tryptophan
Tryptophan is one of the 10 essential amino acids which the body uses to synthesize the proteins for brain cells need, thus enhancing the nerve cells in information transmitting between themselves and cells in the parts of the body that reduces the risk of anxiety and depression, according to the study of "The effects of tryptophan depletion on neural responses to emotional words in remitted depression" by Roiser JP, Levy J, Fromm SJ, Nugent AC, Talagala SL, Hasler G, Henn FA, Sahakian BJ, Drevets WC.(1)
2. Manganese
Manganese beside plays an vital role for the proper and normal growth of human bone structure (accodring to the study of "Bone formation within alumina tubes: effect of calcium, manganese, and chromium dopants" by Pabbruwe MB,Standard OC, Sorrell CC, Howlett CR., posted in PubMed (http://www.ncbi.nlm.nih.gov/pubmed/15109850)), it also helps to reduce the risk of cancer, (according to the study of "The effects of 3, 4 or 5 amino salicylic acids onmanganese-induced neuronal death: ER stress and mitochondrial complexes" by Yoon H, Lee GH, Kim DS, Kim KW, Kim HR, Chae HJ., posted in PubMed (http://www.ncbi.nlm.nih.gov/pubmed/21477646 researchers indicated that the salicylate analogues and the antioxidants did not mediate ER stress in this model. The salicylate analogues reduced reactive oxygen species (ROS) and reversed the deficient mitochondrial membrane potential that was induced by Mn. Taken together, the 3, 4, 5 ASA worked in a similar way, regulating the Mn-induced mitochondrial dysfunction and protecting cells.
3. Protein
Protein beside is important building block of bones, muscles, cartilage, skin, and blood, it also enhances the nervous system in information transmitting between cells and cells of the other parts of the body, thus reducing the risk of nervous tension, (according to the study of "The planar polarity protein Scribble1 is essential for neuronal plasticity and brain function" by Moreau MM, Piguel N, Papouin T, Koehl M, Durand CM, Rubio ME, Loll F, Richard EM, Mazzocco C, Racca C, Oliet SH, Abrous DN, Montcouquiol M, Sans N, posted in PubMed (http://www.ncbi.nlm.nih.gov/pubmed/20660256)
4. Niacin or vitamin B3
Niacin or vitamin B3 beside is important in production of energy in metabolism of carbohydrate, it also essential for DNA repairing, according to the study of `Niacindeficiency delays DNA excision repair and increases spontaneous and nitrosourea-induced chromosomal instability in rat bone marrow`by Kostecki LM, Thomas M, Linford G, Lizotte M, Toxopeus L, Bartleman AP, Kirkland JB., posted in PubMed (http://www.ncbi.nlm.nih.gov/pubmed/17618655), production of steroid hormones in the adrenal gland, improving blood circulation and lowering the bad cholesterol (LDL) levels., according to the study of `Lowering LDL cholesterol with margarine containing plant stanol/sterol esters: is it still relevant in 2011?`by Doggrell SA., posted in PubMed (http://www.ncbi.nlm.nih.gov/pubmed/21296266)
5. Etc.
C. Other health benefits
Since soy sauce contains high amount of sodium, a trace mineral is classified as a cause of heart diseases and stroke if eating in high amount. In fact with correct amount, soy sauce not only helps to replace the daily intake of sodium but also enhances health benefits
1. Cholesterol
Certain studies found that certain types of soy sauce (popular in Chinese cookery) have been shown to reduce the levels of bad cholesterol (LDL) because of the existence of large amounts of the isoflavones, so choose your soy sauce wisely, according to the study of `Soy isoflavones lower serum total and LDL cholesterolin humans: a meta-analysis of 11 randomized controlled trials`by Taku K, Umegaki K, Sato Y, Taki Y, Endoh K, Watanabe S., posted in PubMed (http://www.ncbi.nlm.nih.gov/pubmed/17413118)
2. Isoflavones
Isoflavones is one of the weak estrogen that can compete with estrogen for the same receptor sites, as it decreasing the health risks of excess estrogen, promoting healthy menstrual cycle and reducing the risk of cancers caused by high levels of strong estrogen., according to the study of `Red clover and soyisoflavones-an in vitro safety assessment`by Reiter E, Gerster P, Jungbauer A., posted in PubMed (http://www.ncbi.nlm.nih.gov/pubmed/21801124), researchers wrote that
Isoflavones and plant extracts significantly reduced the proliferation activity of the treated cancer cell lines.
3. Riboflavin
Riboflavin or vitamin B2 besides is important for the production of energy in the metabolism of fats, carbohydrates, and proteins due to its coenzymes, flavin adenine dinucleotide and Flavin mononucleotide properties, it also is the best of natural element for treating migraines and muscle pain reliever used together with magnesium, according to the study of `Effectiveness of high-dose riboflavin inmigraine prophylaxis. A randomized controlled trial`by Schoenen J, Jacquy J, Lenaerts M., posted in PubMed (http://www.ncbi.nlm.nih.gov/pubmed/9484373)
4. Magnesium
Magnesium beside helps to maintain the right ratio with calcium, thus aiding the digestive system in absorption of calcium, according to the study of `Associations of calcium and magnesium in serum and hair with bone mineral density in premenopausal women`by Song CH, Barrett-Connor E, Chung JH, Kim SH, Kim KS., posted in PubMed (http://www.ncbi.nlm.nih.gov/pubmed/17848724) it also reduces the risk of irregular heart beat and impairs glucose tolerance, according to the study of `Dietary magnesium deficiency induces heart rhythm changes, impairs glucose tolerance, and decreases serum cholesterol in post menopausal women`by Nielsen FH, Milne DB, Klevay LM, Gallagher S, Johnson L., posted in PubMed (http://www.ncbi.nlm.nih.gov/pubmed/17536123)
5. Etc.
Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Sources
(a) http://www.ncbi.nlm.nih.gov/pubmed/22139566
(b) http://www.ncbi.nlm.nih.gov/pubmed/19240374
(c) http://www.ncbi.nlm.nih.gov/pubmed/15492861
(d) http://www.ncbi.nlm.nih.gov/pubmed?term=Shoyu%20and%20breast%20cancer
(e) http://www.ncbi.nlm.nih.gov/pubmed/18813866
(1) http://www.ncbi.nlm.nih.gov/pubmed/19539268
General Health: Candida Albicans: Treatment and Controlling of Candida Albicans Overgrowth - The Effectiveness of Vitamins
Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
What is Candida Albicans
Candida albicans are members of a large group of micro organism whose cells contain complex structures enclosed within the membranes, including yeast(2)(3), fungi(4)(5)(6), and mold(6) that live among the gut flora in the human mouth and gastrointestinal tract. In fact, under normal circumstances, Candida albicans that do not cause harmful effects, but overgrowth results in candidiasis. Non-albicansCandida (NAC) species cause 35-65% of all candidaemias in the general patient population(1). According to joint study, in many cases, biofilm(microorganisms with cells stick to each other on a surface) formation(7) gene mutations(8) and overexpression of genes(9)(10) are often associated with increased Candidaresistance toward antifungal agents.
Treatments and controllings
B. Vitamins
1. Vitamin B2
Vitamin B2 required for a wide variety of cellular processes, plays a key role in energy metabolism, enhances the digestive system in absorbing nutrients and supports the immune system(230)(231) in fighting against bacteria causes of inflammatory disease, including candida(232).
2. Vitamin C
Vitamin C, a water-soluble vitamin and an antioxidant found in high concentrations in immune cells, is not only important in aiding the digestive system in absorbing nutrients, but also enhances the production of white blood cell(233)(234) of the immune system(235) in protection of the body by binding to the harmful bacteria(236) and ingesting them.
3. Vitamin A
Retinoic acid, appears to maintain normal skin health by switching on genes and differentiating keratinocytes (immature skin cells)(237) into mature epidermal cells and helps to detoxify liver(238), and enhances the immune system(239)(240) in protecting our body through its antimicrobial functions, including candida albicans(241).
4. Vitamin E
Vitamin E is fat-soluble compounds included both tocopherols and tocotrienols. It besides is an polyphenol antioxidants(242)(246) in scavenging free radicals, but also promotes the immune system in enhanced functions of B-cells(244)(245), the immune cells(245)(247) in production of antibodies to destroy microorganisms.
5. Etc.
Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
References
(1) Non-albicans Candida spp. causing fungaemia: pathogenicity and antifungal resistance by Krcmery V1, Barnes AJ.(PubMed)
(2) Pathogenicity and drug resistance in Candida albicans and other yeast species. A review by Mishra NN1, Prasad T, Sharma N, Payasi A, Prasad R, Gupta DK, Singh R.(PubMed)
(3) Multidrug resistance in yeast Candida by Prasad R1, Kapoor K.(PubMerd)
(4) New evidence that Candida albicans possesses additional ATP-binding cassette MDR-like genes: implications for antifungal azole resistance. by Walsh TJ1, Kasai M, Francesconi A, Landsman D, Chanock SJ.(PubMed)
(5) Mechanisms of resistance to azole antifungal agents in Candida albicansisolates from AIDS patients involve specific multidrug transporters.by Sanglard D1, Kuchler K, Ischer F, Pagani JL, Monod M, Bille J.(PubMed)
(6) Structural analysis of phospho-D-mannan-protein complexes isolated from yeast and mold form cells of Candida albicans NIH A-207 serotype A strain by Shibata N1, Fukasawa S, Kobayashi H, Tojo M, Yonezu T, Ambo A, Ohkubo Y, Suzuki S.(PubMed)
(7) The effect of antifungal combination on transcripts of a subset of drug-resistance genes in clinical isolates of Candida species induced biofilms by Ibrahim NH1, Melake NA2, Somily AM3, Zakaria AS4, Baddour MM5, Mahmoud AZ6(PubMed)
(8) Antifungal drug resistance in pathogenic fungi. by Vanden Bossche H1, Dromer F, Improvisi I, Lozano-Chiu M, Rex JH, Sanglard D.(PubMed)
(9) The genetic basis of fluconazole resistance development in Candida albicansby Morschhäuser J1.(PubMed)
(10) A proteomic approach to understanding the development of multidrug-resistantCandida albicans strains by Kusch H1, Biswas K, Schwanfelder S, Engelmann S, Rogers PD, Hecker M, Morschhäuser J.(PubMed)
(230) Edible mushrooms: improving human health and promoting quality life by Valverde ME1, Hernández-Pérez T1, Paredes-López O1.(PubMed)
(231) [Effect of some vitamins on activity of immunocompetent cells].[Article in Russian]by Nezgovorov DV.(PubMed)
(232) Antioxidants keep the potentially probiotic but highly oxygen-sensitive human gut bacterium Faecalibacterium prausnitzii alive at ambient air by Khan MT1, van Dijl JM1, Harmsen HJ1.(PubMed)
(233) Storing red blood cells with vitamin C and N-acetylcysteine prevents oxidative stress-related lesions: a metabolomics overview by Pallotta V1, Gevi F1, D'alessandro A1, Zolla L1.(PubMed)
(234) Red blood cell metabolism under prolonged anaerobic storage by D'Alessandro A1, Gevi F, Zolla L.(PubMed)
(235) Alterations in antioxidant defense system of workers chronically exposed to arsenic, cadmium and mercury from coal flying ash by Zeneli L1, Sekovanić A, Ajvazi M, Kurti L, Daci N.(PubMed)
(236) Indomethacin-induced translocation of bacteria across enteric epithelia is reactive oxygen species-dependent and reduced by vitamin C by Schoultz I1, McKay CM, Graepel R, Phan VC, Wang A, Söderholm J, McKay DM.(PubMed)
(237) Vitamin C derivative ascorbyl palmitate promotes ultraviolet-B-induced lipid peroxidation and cytotoxicity in keratinocytes by Meves A1, Stock SN, Beyerle A, Pittelkow MR, Peus D.(PubMed)
238. Effects of dried fish on antioxidant levels in rat liver by Anilakumar KR1, Khanum F, Krishna KR, Viswanathan KR.(PubMed)
(239) Vitamin A and retinoic acid in T cell-related immunity by Ross AC1.(PubMed)
(240) Vitamin A and immune regulation: role of retinoic acid in gut-associated dendritic cell education, immune protection and tolerance by Cassani B1, Villablanca EJ, De Calisto J, Wang S, Mora JR.(PubMed)
(241) Modulatory role of vitamin A on the Candida albicans-induced immune response in human monocytes by Klassert TE1, Hanisch A, Bräuer J, Klaile E, Heyl KA, Mansour MK, Tam JM, Vyas JM, Slevogt H.(PubMed)
(242) [Toxicology of the synthetic antioxidants BHA and BHT in comparison with the natural antioxidant vitamin E].[Article in German]by Kahl R1, Kappus H.(PubMed)
(243) Effectiveness of antioxidants (vitamin C and E) with and without sunscreens as topical photoprotectants by Darr D1, Dunston S, Faust H, Pinnell S.(PubMed)
(244) Immune dysfunction and cytokine production in hemodialysis. Could they be lessened by vitamin E-coated dialyzer membrane by Senatore M, Cecere P, Colombo P, Costantini L, Filiberti O, Piccini G, Peona C, Buemi M, Nicoletti A, Rizzuto G.(PubMed)
(245) Prospective crossover trial of the influence of vitamin E-coated dialyzer membranes on T-cell activation and cytokine induction by Girndt M1, Lengler S, Kaul H, Sester U, Sester M, Köhler H.(PubMed)
(246) Vitamin E and immunity by Moriguchi S1, Muraga M.(PubMed)
(247) The role of vitamin E in T-cell differentiation and the decrease of cellularimmunity with aging.by Moriguchi S1.(PubMed)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
What is Candida Albicans
Candida albicans are members of a large group of micro organism whose cells contain complex structures enclosed within the membranes, including yeast(2)(3), fungi(4)(5)(6), and mold(6) that live among the gut flora in the human mouth and gastrointestinal tract. In fact, under normal circumstances, Candida albicans that do not cause harmful effects, but overgrowth results in candidiasis. Non-albicansCandida (NAC) species cause 35-65% of all candidaemias in the general patient population(1). According to joint study, in many cases, biofilm(microorganisms with cells stick to each other on a surface) formation(7) gene mutations(8) and overexpression of genes(9)(10) are often associated with increased Candidaresistance toward antifungal agents.
Treatments and controllings
B. Vitamins
1. Vitamin B2
Vitamin B2 required for a wide variety of cellular processes, plays a key role in energy metabolism, enhances the digestive system in absorbing nutrients and supports the immune system(230)(231) in fighting against bacteria causes of inflammatory disease, including candida(232).
2. Vitamin C
Vitamin C, a water-soluble vitamin and an antioxidant found in high concentrations in immune cells, is not only important in aiding the digestive system in absorbing nutrients, but also enhances the production of white blood cell(233)(234) of the immune system(235) in protection of the body by binding to the harmful bacteria(236) and ingesting them.
3. Vitamin A
Retinoic acid, appears to maintain normal skin health by switching on genes and differentiating keratinocytes (immature skin cells)(237) into mature epidermal cells and helps to detoxify liver(238), and enhances the immune system(239)(240) in protecting our body through its antimicrobial functions, including candida albicans(241).
4. Vitamin E
Vitamin E is fat-soluble compounds included both tocopherols and tocotrienols. It besides is an polyphenol antioxidants(242)(246) in scavenging free radicals, but also promotes the immune system in enhanced functions of B-cells(244)(245), the immune cells(245)(247) in production of antibodies to destroy microorganisms.
5. Etc.
Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
References
(1) Non-albicans Candida spp. causing fungaemia: pathogenicity and antifungal resistance by Krcmery V1, Barnes AJ.(PubMed)
(2) Pathogenicity and drug resistance in Candida albicans and other yeast species. A review by Mishra NN1, Prasad T, Sharma N, Payasi A, Prasad R, Gupta DK, Singh R.(PubMed)
(3) Multidrug resistance in yeast Candida by Prasad R1, Kapoor K.(PubMerd)
(4) New evidence that Candida albicans possesses additional ATP-binding cassette MDR-like genes: implications for antifungal azole resistance. by Walsh TJ1, Kasai M, Francesconi A, Landsman D, Chanock SJ.(PubMed)
(5) Mechanisms of resistance to azole antifungal agents in Candida albicansisolates from AIDS patients involve specific multidrug transporters.by Sanglard D1, Kuchler K, Ischer F, Pagani JL, Monod M, Bille J.(PubMed)
(6) Structural analysis of phospho-D-mannan-protein complexes isolated from yeast and mold form cells of Candida albicans NIH A-207 serotype A strain by Shibata N1, Fukasawa S, Kobayashi H, Tojo M, Yonezu T, Ambo A, Ohkubo Y, Suzuki S.(PubMed)
(7) The effect of antifungal combination on transcripts of a subset of drug-resistance genes in clinical isolates of Candida species induced biofilms by Ibrahim NH1, Melake NA2, Somily AM3, Zakaria AS4, Baddour MM5, Mahmoud AZ6(PubMed)
(8) Antifungal drug resistance in pathogenic fungi. by Vanden Bossche H1, Dromer F, Improvisi I, Lozano-Chiu M, Rex JH, Sanglard D.(PubMed)
(9) The genetic basis of fluconazole resistance development in Candida albicansby Morschhäuser J1.(PubMed)
(10) A proteomic approach to understanding the development of multidrug-resistantCandida albicans strains by Kusch H1, Biswas K, Schwanfelder S, Engelmann S, Rogers PD, Hecker M, Morschhäuser J.(PubMed)
(230) Edible mushrooms: improving human health and promoting quality life by Valverde ME1, Hernández-Pérez T1, Paredes-López O1.(PubMed)
(231) [Effect of some vitamins on activity of immunocompetent cells].[Article in Russian]by Nezgovorov DV.(PubMed)
(232) Antioxidants keep the potentially probiotic but highly oxygen-sensitive human gut bacterium Faecalibacterium prausnitzii alive at ambient air by Khan MT1, van Dijl JM1, Harmsen HJ1.(PubMed)
(233) Storing red blood cells with vitamin C and N-acetylcysteine prevents oxidative stress-related lesions: a metabolomics overview by Pallotta V1, Gevi F1, D'alessandro A1, Zolla L1.(PubMed)
(234) Red blood cell metabolism under prolonged anaerobic storage by D'Alessandro A1, Gevi F, Zolla L.(PubMed)
(235) Alterations in antioxidant defense system of workers chronically exposed to arsenic, cadmium and mercury from coal flying ash by Zeneli L1, Sekovanić A, Ajvazi M, Kurti L, Daci N.(PubMed)
(236) Indomethacin-induced translocation of bacteria across enteric epithelia is reactive oxygen species-dependent and reduced by vitamin C by Schoultz I1, McKay CM, Graepel R, Phan VC, Wang A, Söderholm J, McKay DM.(PubMed)
(237) Vitamin C derivative ascorbyl palmitate promotes ultraviolet-B-induced lipid peroxidation and cytotoxicity in keratinocytes by Meves A1, Stock SN, Beyerle A, Pittelkow MR, Peus D.(PubMed)
238. Effects of dried fish on antioxidant levels in rat liver by Anilakumar KR1, Khanum F, Krishna KR, Viswanathan KR.(PubMed)
(239) Vitamin A and retinoic acid in T cell-related immunity by Ross AC1.(PubMed)
(240) Vitamin A and immune regulation: role of retinoic acid in gut-associated dendritic cell education, immune protection and tolerance by Cassani B1, Villablanca EJ, De Calisto J, Wang S, Mora JR.(PubMed)
(241) Modulatory role of vitamin A on the Candida albicans-induced immune response in human monocytes by Klassert TE1, Hanisch A, Bräuer J, Klaile E, Heyl KA, Mansour MK, Tam JM, Vyas JM, Slevogt H.(PubMed)
(242) [Toxicology of the synthetic antioxidants BHA and BHT in comparison with the natural antioxidant vitamin E].[Article in German]by Kahl R1, Kappus H.(PubMed)
(243) Effectiveness of antioxidants (vitamin C and E) with and without sunscreens as topical photoprotectants by Darr D1, Dunston S, Faust H, Pinnell S.(PubMed)
(244) Immune dysfunction and cytokine production in hemodialysis. Could they be lessened by vitamin E-coated dialyzer membrane by Senatore M, Cecere P, Colombo P, Costantini L, Filiberti O, Piccini G, Peona C, Buemi M, Nicoletti A, Rizzuto G.(PubMed)
(245) Prospective crossover trial of the influence of vitamin E-coated dialyzer membranes on T-cell activation and cytokine induction by Girndt M1, Lengler S, Kaul H, Sester U, Sester M, Köhler H.(PubMed)
(246) Vitamin E and immunity by Moriguchi S1, Muraga M.(PubMed)
(247) The role of vitamin E in T-cell differentiation and the decrease of cellularimmunity with aging.by Moriguchi S1.(PubMed)
Most common Diseases of 50plus: Obesity and Obesity's complication of Obesity Hypoventilation Syndrome
Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Obesity is a medical condition of excess body fat accumulated overtime, while overweight is a condition of excess body weight relatively to the height. According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered over weight, while a BMI of over 30 is an indication of obesity. According to the statistic, 68% of American population are either overweight or obese.
You can calculate your BMI index BMI= weight (kg)/ height (m2)
Obesity hypoventilation syndrome is defined as a condition of low blood oxygen levels and high blood carbon dioxide (CO2) levels in the body of severe obese people who can not breath rapidly and deeply.
How Obesity associates with Obesity Hypoventilation Syndrome
1. In a study of "[Obesity and Sleep-related Breathing Disorders]" Luo JM, Xiao Y., posted in PubMed, researchers wrote that Obesity, with an increasing prevalence,has become one of the most common metabolic diseases. Obesity is associated with many respiratory diseases, especially sleep-related breathing disorders including obstructive sleep apnea-hypopnea syndrome, obesity hypoventilation syndrome, and overlap syndrome. This article reviews the association between obesity and these sleep-related breathing disorders.
2. According to a study of "The pickwickian syndrome-obesity hypoventilation syndrome" by Littleton SW, Mokhlesi B., posted in PubMed, researchers wrote that Obesity-hypoventilation syndrome (OHS), also historically described as the Pickwickian syndrome, consists of the triad of obesity, sleep disordered breathing, and chronic hypercapnia during wakefulness in the absence of other known causes of hypercapnia. Its exact prevalence is unknown, but it has been estimated that 10% to 20% of obese patients with obstructive sleep apnea have hypercapnia
3. In the abstract of the study of "Respiratory complications of obesity" [Article in English, Spanish] by Rabec C, de Lucas Ramos P, Veale D., posted in PubMed, researchers indicated that Obesity, well known as a cardiovascular risk factor, can also lead to significant respiratory complications. The respiratory changes associated with obesity extend from a simple change in respiratory function, with no effect on gas exchange, to the more serious condition of hypercapnic respiratory failure, characteristic of obesity hypoventilation syndrome. More recently, it has been reported that there is an increased prevalence of asthma which is probably multifactorial in origin, but in which inflammation may play an important role.
4. In a study of "Influence of body mass index on treatment of breathing-related sleep disorders" by Dzieciolowska-Baran E, Gawlikowska-Sroka A, Poziomkotska-Gesicka I, Teul-Swiniarska I, Sroczynski T., posted in PubMed, researchers found that the analysis demonstrated a significant influence of body mass on snoring, particularly in complicated and severe types of breathing disorders, such obstructive sleep apnea or hypopnea, and the obesity hypoventilation syndrome. Corrective interventions carried out to eliminate anatomical abnormalities causing obstruction of upper airways provided the best therapeutic effects in patients with normal body mass.
5. According to the study of "Sleep-related breathing disorders, loud snoring and excessive daytime sleepiness in obese subjects" by Resta O, Foschino-Barbaro MP, Legari G, Talamo S, Bonfitto P, Palumbo A, Minenna A, Giorgino R, De Pergola G., posted in PubMed, researchers concluded that OSA is present in more than 50% of a population of obese patients with a mean BMI higher than 40.0, this percentage being much higher than that commonly reported in previous studies, particularly in women. Neck circumference in men and BMI in women seem to be the strongest predictors of the severity of OSA in obese patients. Nocturnal hypoventilation seems to be present in more than 29% of a severe obese population. Moreover, this study indicates that morbid obesity can be associated with excessive daytime sleepiness even in the absence of sleep apnea.
6. Etc.
Treatments of Obesity and Obesity Hypoventilation Syndrome
1. According to the study of "Noninvasive Ventilation in Mild obesity hypoventilation syndrome: A randomized controlled trial" by Borel JC, Tamisier R, Gonzalez-Bermejo J, Baguet JP, Monneret D, Arnol N, Roux-Lombard P, Wuyam B, Levy P, Pepin JL, posted in PubMed, researchers found that NIV group patients (n=18) were older (58±11 versus 54±6 years) with a higher baseline PaCO(2) (47.9±4.2 versus 45.2±3 mmHg). In intention to treat analysis, compared to control group, NIV significantly reduced daytime PaCO(2) (difference between treatments: -3.5 mmHg; 95%CI:-6.2 to -0.8) and apnea-hypopnea-index (-40.3/h 95%CI:-62.4 to -18.2). Sleep architecture was restored although non-respiratory micro-arousals increased (+9.4/hour of sleep; 95%CI: 1.9 to 16.9) and daytime sleepiness was not completely normalized. Despite a dramatic improvement in sleep hypoxemia, glucidic and lipidic metabolism parameters as well as cytokines profiles did not vary significantly. Accordingly, neither RH-PAT (+0.02; 95%CI: -0.24 to 0.29) nor arterial stiffness (+0.22m.s(-1); 95%CI: -1.47 to 1.92) improved.
2. According to the study of "Obesity hypoventilation syndrome" by Al Dabal L, Bahammam AS., posted in PubMed, researchers indicated that Despite its major impact on health, this disorder is under-recognized and under-diagnosed. Available management options include aggressive weight reduction, oxygen therapy and using positive airway pressure techniques. In this review, we will go over the epidemiology, pathophysiology, presentation and diagnosis and management of OHS.
3. In the abstract of the study of "Diagnosis and management of obesity hypoventilation syndrome in the ICU" by Lee WY, Mokhlesi B., posted inPubMed, researchers concluded that Because of the global obesity epidemic and the high prevalence of obstructive sleep apnea in the general population, critical care physicians are likely to encounter patients who have acute-on-chronic respiratory failure attributable to OHS in their clinical practice. In this article we define the clinical characteristics of OHS, review its pathophysiology, and discuss the morbidity and mortality associated with OHS. Finally, we offer treatment strategies during ICU management using noninvasive positive pressure ventilation that may guide the physician in the care of these challenging patients.
Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Obesity is a medical condition of excess body fat accumulated overtime, while overweight is a condition of excess body weight relatively to the height. According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered over weight, while a BMI of over 30 is an indication of obesity. According to the statistic, 68% of American population are either overweight or obese.
You can calculate your BMI index BMI= weight (kg)/ height (m2)
Obesity hypoventilation syndrome is defined as a condition of low blood oxygen levels and high blood carbon dioxide (CO2) levels in the body of severe obese people who can not breath rapidly and deeply.
How Obesity associates with Obesity Hypoventilation Syndrome
1. In a study of "[Obesity and Sleep-related Breathing Disorders]" Luo JM, Xiao Y., posted in PubMed, researchers wrote that Obesity, with an increasing prevalence,has become one of the most common metabolic diseases. Obesity is associated with many respiratory diseases, especially sleep-related breathing disorders including obstructive sleep apnea-hypopnea syndrome, obesity hypoventilation syndrome, and overlap syndrome. This article reviews the association between obesity and these sleep-related breathing disorders.
2. According to a study of "The pickwickian syndrome-obesity hypoventilation syndrome" by Littleton SW, Mokhlesi B., posted in PubMed, researchers wrote that Obesity-hypoventilation syndrome (OHS), also historically described as the Pickwickian syndrome, consists of the triad of obesity, sleep disordered breathing, and chronic hypercapnia during wakefulness in the absence of other known causes of hypercapnia. Its exact prevalence is unknown, but it has been estimated that 10% to 20% of obese patients with obstructive sleep apnea have hypercapnia
3. In the abstract of the study of "Respiratory complications of obesity" [Article in English, Spanish] by Rabec C, de Lucas Ramos P, Veale D., posted in PubMed, researchers indicated that Obesity, well known as a cardiovascular risk factor, can also lead to significant respiratory complications. The respiratory changes associated with obesity extend from a simple change in respiratory function, with no effect on gas exchange, to the more serious condition of hypercapnic respiratory failure, characteristic of obesity hypoventilation syndrome. More recently, it has been reported that there is an increased prevalence of asthma which is probably multifactorial in origin, but in which inflammation may play an important role.
4. In a study of "Influence of body mass index on treatment of breathing-related sleep disorders" by Dzieciolowska-Baran E, Gawlikowska-Sroka A, Poziomkotska-Gesicka I, Teul-Swiniarska I, Sroczynski T., posted in PubMed, researchers found that the analysis demonstrated a significant influence of body mass on snoring, particularly in complicated and severe types of breathing disorders, such obstructive sleep apnea or hypopnea, and the obesity hypoventilation syndrome. Corrective interventions carried out to eliminate anatomical abnormalities causing obstruction of upper airways provided the best therapeutic effects in patients with normal body mass.
5. According to the study of "Sleep-related breathing disorders, loud snoring and excessive daytime sleepiness in obese subjects" by Resta O, Foschino-Barbaro MP, Legari G, Talamo S, Bonfitto P, Palumbo A, Minenna A, Giorgino R, De Pergola G., posted in PubMed, researchers concluded that OSA is present in more than 50% of a population of obese patients with a mean BMI higher than 40.0, this percentage being much higher than that commonly reported in previous studies, particularly in women. Neck circumference in men and BMI in women seem to be the strongest predictors of the severity of OSA in obese patients. Nocturnal hypoventilation seems to be present in more than 29% of a severe obese population. Moreover, this study indicates that morbid obesity can be associated with excessive daytime sleepiness even in the absence of sleep apnea.
6. Etc.
Treatments of Obesity and Obesity Hypoventilation Syndrome
1. According to the study of "Noninvasive Ventilation in Mild obesity hypoventilation syndrome: A randomized controlled trial" by Borel JC, Tamisier R, Gonzalez-Bermejo J, Baguet JP, Monneret D, Arnol N, Roux-Lombard P, Wuyam B, Levy P, Pepin JL, posted in PubMed, researchers found that NIV group patients (n=18) were older (58±11 versus 54±6 years) with a higher baseline PaCO(2) (47.9±4.2 versus 45.2±3 mmHg). In intention to treat analysis, compared to control group, NIV significantly reduced daytime PaCO(2) (difference between treatments: -3.5 mmHg; 95%CI:-6.2 to -0.8) and apnea-hypopnea-index (-40.3/h 95%CI:-62.4 to -18.2). Sleep architecture was restored although non-respiratory micro-arousals increased (+9.4/hour of sleep; 95%CI: 1.9 to 16.9) and daytime sleepiness was not completely normalized. Despite a dramatic improvement in sleep hypoxemia, glucidic and lipidic metabolism parameters as well as cytokines profiles did not vary significantly. Accordingly, neither RH-PAT (+0.02; 95%CI: -0.24 to 0.29) nor arterial stiffness (+0.22m.s(-1); 95%CI: -1.47 to 1.92) improved.
2. According to the study of "Obesity hypoventilation syndrome" by Al Dabal L, Bahammam AS., posted in PubMed, researchers indicated that Despite its major impact on health, this disorder is under-recognized and under-diagnosed. Available management options include aggressive weight reduction, oxygen therapy and using positive airway pressure techniques. In this review, we will go over the epidemiology, pathophysiology, presentation and diagnosis and management of OHS.
3. In the abstract of the study of "Diagnosis and management of obesity hypoventilation syndrome in the ICU" by Lee WY, Mokhlesi B., posted inPubMed, researchers concluded that Because of the global obesity epidemic and the high prevalence of obstructive sleep apnea in the general population, critical care physicians are likely to encounter patients who have acute-on-chronic respiratory failure attributable to OHS in their clinical practice. In this article we define the clinical characteristics of OHS, review its pathophysiology, and discuss the morbidity and mortality associated with OHS. Finally, we offer treatment strategies during ICU management using noninvasive positive pressure ventilation that may guide the physician in the care of these challenging patients.
Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Monday, May 30, 2016
Food therapy - Whole wheat (Triticum)
Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Whole wheat
Wheat is a type of glass originally from the Middle East, but now cultivated worldwide for commercial purposes. In its natural unrefined state, it contains many important nutrients that can help nourish the healthy body and enhances fertility in men and women alike.
Nutrients
1. Carbohydrates
2. Dietary fiber
3. Protein
4. Vitamin B Complex
5. Tryptophan
6. Calcium
7. Iron
8. Magnesium
9. Manganese
10. Phosphorus
11. Potassium
12. Zinc
13. Etc.
Heath Benefits
A. Health benefits according to studies
1. Hyperglycemic/hyperinsulinemic effects
In the assessment to the effects of 6-week consumption of whole grain wheatsourdough bread in comparison to white bread on fasting serum lipids in normoglycemic/normoinsulinemic (NGI; n = 14) and hyperglycemic/hyperinsulinemic (HGI; n = 14) adults, found that add to limited literature comparing wheat whole grains to wheat refined grains on CVD risk and highlight the need to consider genetic variation in relation to lipoprotein lipid content and CVD risk, according to "The effect of whole grain wheat sourdough bread consumption on serum lipids in healthy normoglycemic/normoinsulinemic and hyperglycemic/hyperinsulinemic adults depends on presence of the APOE E3/E3 genotype: a randomized controlled trial" by Tucker AJ, Mackay KA, Robinson LE, Graham TE, Bakovic M, Duncan AM.(a)
2. Prostate cancer progression
In the investigation of rye whole grain and bran products (RP) or refined wheatproducts with added cellulose (WP) and theirs effect on pregression of prostate cancer found that Daily excretion of 5 lignans was higher after the RP treatment than after the WP treatment (P < 0.001). We conclude that whole grain and bran from rye resulted in significantly lower plasma PSA compared with a cellulose-supplemented refined wheat diet in patients with prostate cancer. The effect may be related to inhibition of prostate cancer progression caused by decreased exposure to insulin, as indicated by plasma insulin and urinary C-peptide excretion, according to "Rye whole grain and bran intake compared with refined wheatdecreases urinary C-peptide, plasma insulin, and prostate specific antigen in men with prostate cancer" by Landberg R, Andersson SO, Zhang JX, Johansson JE, Stenman UH, Adlercreutz H, Kamal-Eldin A, Aman P, Hallmans G.(b)
3. Antioxidants
In the classification of Anthocyanins of whole purple wheat, unpolished red rice, and partially polished red rice before and after processing to produce infant cereals and it antioxidant efect found that purple wheat infant cereals had higher cellular antioxidant activity than unpolished red rice ones (p < 0.05). Whole purple wheatinfant cereals showed higher antioxidant activity than the commercial infant cereal, suggesting a possibility of improving infant antioxidant status by incorporating this grain in their diet, according to "Comparative Evaluation of the Antioxidant Potential of Infant Cereals Produced from Purple Wheat and Red Rice Grains and LC-MS Analysis of Their Anthocyanins" by Hirawan R, Diehl-Jones W, Beta T.(c)
4. Glucose and Lipid metabolism
In the observation of Whole grain products, fish and bilberries and theirs effect on Glucose and Lipid metabolism found that the diet rich in whole grain and low insulin response grain products, bilberries, and fatty fish improve glucose metabolism and alter the lipidomic profile. Therefore, such a diet may have a beneficial effect in the efforts to prevent type 2 diabetes in high risk persons, according to "Whole grain products, fish and bilberries alter glucose and lipid metabolism in a randomized, controlled trial: the Sysdimet study" byLankinen M, Schwab U, Kolehmainen M, Paananen J, Poutanen K, Mykkänen H, Seppänen-Laakso T, Gylling H, Uusitupa M, Orešič M.(d)
5. Etc.
B. Health benefits according to concentration
1. Manganese
It is one of important trace in preventing osteroposis, according to the study of "[Study of estrogen deficiency impact on manganese levels in teeth and mandible of rats after ovariectomy]. [Article in Polish]" by Rahnama M, Błoniarz J, Zareba S, Swiatkowski W.(4)and regulating blood sugar level, according to the study of "[An inadequate intake of manganese may favour insulin resistance in girls]. [Article in Spanish]" by Rodríguez-Rodríguez E, Bermejo LM, López-Sobaler AM, Ortega RM.(I)
2. Dietary fiber
Since it contains high levels of fiber, it reduces the risk of type II diabetes and insulin sensitive, according to the study of "Efficacy of high-fiber diets in the management of type 2 diabetes mellitus" by Wolfram T, Ismail-Beigi F., posted in PubMed(II)
3. Tryptophan
Tryptophan is one of the 10 essential amino acids which the body uses to synthesize the proteins for brain cells need, thus enhancing the nerve cells in information transmitting between themselves and cells in the parts of the body that reduces the risk of anxiety and depression, according to the study of "The effects of tryptophan depletion on neural responses to emotional words in remitted depression" by Roiser JP, Levy J, Fromm SJ, Nugent AC, Talagala SL, Hasler G, Henn FA, Sahakian BJ, Drevets WC.(III)
4. Magnesium
Magnesium not only important for bone health, according to the study of "Magnesium, zinc, copper, manganese, and selenium levels in postmenopausal women with osteoporosis. Can magnesium play a key role in osteoporosis?" by Odabasi E, Turan M, Aydin A, Akay C, Kutlu M(6) but also play and important role in protecting against Alzheimer's disease, according to the study of "Altered ionized magnesium levels in mild-to-moderate Alzheimer's disease" by Barbagallo M, Belvedere M, Di Bella G, Dominguez LJ.(IV)
5. Etc.
C. Other health benefits
1. Weight control and body organs
Since whole wheat in its natural state, it contains high amount of fiber that can reduce the fluctuation of insulin and the risk of depress of pancreas that can increase appetite and weigh gain., according to the study of "The effect of usingwhole wheat grain in the diet of game pheasants on their body weight, dimensions and development of some internal organs" by Kokoszyński D, Bernacki Z, Cisowska A., posted in PubMed(1).
2. Diabetes
Since fiber also reduces the risk of insulin sensitive by releasing sugar slowly in to blood stream, thus decreasing the risk of type II diabetes, according to the study of "Efficacy of high-fiber diets in the management of type 2 diabetes mellitus" by Wolfram T, Ismail-Beigi F., posted pubMed(2).
3. High blood pressure, heart disease and stroke
As we mention in the previous article, high levels of magnesium reduces the risk of blood clot by dilating blood vessels, according to the study of "Magnesiumcauses nitric oxide independent coronary artery vasodilation in humans" by Teragawa H, Kato M, Yamagata T, Matsuura H, Kajiyama G., posted in PubMed(3), thus decreasing the risk of high blood pressure, heart disease and stroke.
4. Cholesterol Levels
Whole wheat contains plant sterols and stanols which are proven to be effective in slowing the progression of atherosclerosis by reserving atherosclerosis naturally caused by cholesterol builds up the plaques inside the arteries, leading arteries clogged, resulting in cardiovascular diseases, according to the study of "New insights into the molecular actions of plant sterols and stanols in cholesterolmetabolism" by Calpe-Berdiel L, Escolà-Gil JC, Blanco-Vaca F., posted in PubMed(4).
5. Breast cancer
High levels of lignan in whole wheat acts as antioxidant that improves the immune function in fighting against irregular cell growth, thus reducing the risk of cancer, according to the study of " Avemar, a nontoxic fermented wheat germ extract, attenuates the growth of sensitive and 5-FdUrd/Ara-C cross-resistant H9 human lymphoma cells through induction of apoptosis"byAgarwal RP, Grusch M, Hidvégi M, Jaeger W, Krupitza G, Lackner A, Madlener S, Ozsvar-Kozma M, Saiko P, Szekeres T, Fritzer-Szekeres M, Graser G posted in Journal: Oncology Reports Release date: 2009 (5), researchers found that Avemar exerts a number of beneficial effects which could support conventional chemotherapy of human malignancies.
6. Etc.
Side effects
1. Gliadin in whole wheat can weaken the immune system, leading to inflammation.
2. Wheat allergy.
3. Oxalates
Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Sources
(a) http://www.ncbi.nlm.nih.gov/pubmed/20444273
(b) http://www.ncbi.nlm.nih.gov/pubmed/20980650
(c) http://www.ncbi.nlm.nih.gov/pubmed/22035073
(d) http://www.ncbi.nlm.nih.gov/pubmed/21901116
(I) http://www.ncbi.nlm.nih.gov/pubmed/22072339
(II) http://www.ncbi.nlm.nih.gov/pubmed/20713332
(III) http://www.ncbi.nlm.nih.gov/pubmed/19539268
(IV) http://www.ncbi.nlm.nih.gov/pubmed/21951617
1. http://www.ncbi.nlm.nih.gov/pubmed/20420203
2. http://www.ncbi.nlm.nih.gov/pubmed/20713332
3. http://www.ncbi.nlm.nih.gov/pubmed/114548464.http://www.ncbi.nlm.nih.gov/pubmed/18692849
5. http://www.avemar.com/for_medical_professionals/48
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Whole wheat
Wheat is a type of glass originally from the Middle East, but now cultivated worldwide for commercial purposes. In its natural unrefined state, it contains many important nutrients that can help nourish the healthy body and enhances fertility in men and women alike.
Nutrients
1. Carbohydrates
2. Dietary fiber
3. Protein
4. Vitamin B Complex
5. Tryptophan
6. Calcium
7. Iron
8. Magnesium
9. Manganese
10. Phosphorus
11. Potassium
12. Zinc
13. Etc.
Heath Benefits
A. Health benefits according to studies
1. Hyperglycemic/hyperinsulinemic effects
In the assessment to the effects of 6-week consumption of whole grain wheatsourdough bread in comparison to white bread on fasting serum lipids in normoglycemic/normoinsulinemic (NGI; n = 14) and hyperglycemic/hyperinsulinemic (HGI; n = 14) adults, found that add to limited literature comparing wheat whole grains to wheat refined grains on CVD risk and highlight the need to consider genetic variation in relation to lipoprotein lipid content and CVD risk, according to "The effect of whole grain wheat sourdough bread consumption on serum lipids in healthy normoglycemic/normoinsulinemic and hyperglycemic/hyperinsulinemic adults depends on presence of the APOE E3/E3 genotype: a randomized controlled trial" by Tucker AJ, Mackay KA, Robinson LE, Graham TE, Bakovic M, Duncan AM.(a)
2. Prostate cancer progression
In the investigation of rye whole grain and bran products (RP) or refined wheatproducts with added cellulose (WP) and theirs effect on pregression of prostate cancer found that Daily excretion of 5 lignans was higher after the RP treatment than after the WP treatment (P < 0.001). We conclude that whole grain and bran from rye resulted in significantly lower plasma PSA compared with a cellulose-supplemented refined wheat diet in patients with prostate cancer. The effect may be related to inhibition of prostate cancer progression caused by decreased exposure to insulin, as indicated by plasma insulin and urinary C-peptide excretion, according to "Rye whole grain and bran intake compared with refined wheatdecreases urinary C-peptide, plasma insulin, and prostate specific antigen in men with prostate cancer" by Landberg R, Andersson SO, Zhang JX, Johansson JE, Stenman UH, Adlercreutz H, Kamal-Eldin A, Aman P, Hallmans G.(b)
3. Antioxidants
In the classification of Anthocyanins of whole purple wheat, unpolished red rice, and partially polished red rice before and after processing to produce infant cereals and it antioxidant efect found that purple wheat infant cereals had higher cellular antioxidant activity than unpolished red rice ones (p < 0.05). Whole purple wheatinfant cereals showed higher antioxidant activity than the commercial infant cereal, suggesting a possibility of improving infant antioxidant status by incorporating this grain in their diet, according to "Comparative Evaluation of the Antioxidant Potential of Infant Cereals Produced from Purple Wheat and Red Rice Grains and LC-MS Analysis of Their Anthocyanins" by Hirawan R, Diehl-Jones W, Beta T.(c)
4. Glucose and Lipid metabolism
In the observation of Whole grain products, fish and bilberries and theirs effect on Glucose and Lipid metabolism found that the diet rich in whole grain and low insulin response grain products, bilberries, and fatty fish improve glucose metabolism and alter the lipidomic profile. Therefore, such a diet may have a beneficial effect in the efforts to prevent type 2 diabetes in high risk persons, according to "Whole grain products, fish and bilberries alter glucose and lipid metabolism in a randomized, controlled trial: the Sysdimet study" byLankinen M, Schwab U, Kolehmainen M, Paananen J, Poutanen K, Mykkänen H, Seppänen-Laakso T, Gylling H, Uusitupa M, Orešič M.(d)
5. Etc.
B. Health benefits according to concentration
1. Manganese
It is one of important trace in preventing osteroposis, according to the study of "[Study of estrogen deficiency impact on manganese levels in teeth and mandible of rats after ovariectomy]. [Article in Polish]" by Rahnama M, Błoniarz J, Zareba S, Swiatkowski W.(4)and regulating blood sugar level, according to the study of "[An inadequate intake of manganese may favour insulin resistance in girls]. [Article in Spanish]" by Rodríguez-Rodríguez E, Bermejo LM, López-Sobaler AM, Ortega RM.(I)
2. Dietary fiber
Since it contains high levels of fiber, it reduces the risk of type II diabetes and insulin sensitive, according to the study of "Efficacy of high-fiber diets in the management of type 2 diabetes mellitus" by Wolfram T, Ismail-Beigi F., posted in PubMed(II)
3. Tryptophan
Tryptophan is one of the 10 essential amino acids which the body uses to synthesize the proteins for brain cells need, thus enhancing the nerve cells in information transmitting between themselves and cells in the parts of the body that reduces the risk of anxiety and depression, according to the study of "The effects of tryptophan depletion on neural responses to emotional words in remitted depression" by Roiser JP, Levy J, Fromm SJ, Nugent AC, Talagala SL, Hasler G, Henn FA, Sahakian BJ, Drevets WC.(III)
4. Magnesium
Magnesium not only important for bone health, according to the study of "Magnesium, zinc, copper, manganese, and selenium levels in postmenopausal women with osteoporosis. Can magnesium play a key role in osteoporosis?" by Odabasi E, Turan M, Aydin A, Akay C, Kutlu M(6) but also play and important role in protecting against Alzheimer's disease, according to the study of "Altered ionized magnesium levels in mild-to-moderate Alzheimer's disease" by Barbagallo M, Belvedere M, Di Bella G, Dominguez LJ.(IV)
5. Etc.
C. Other health benefits
1. Weight control and body organs
Since whole wheat in its natural state, it contains high amount of fiber that can reduce the fluctuation of insulin and the risk of depress of pancreas that can increase appetite and weigh gain., according to the study of "The effect of usingwhole wheat grain in the diet of game pheasants on their body weight, dimensions and development of some internal organs" by Kokoszyński D, Bernacki Z, Cisowska A., posted in PubMed(1).
2. Diabetes
Since fiber also reduces the risk of insulin sensitive by releasing sugar slowly in to blood stream, thus decreasing the risk of type II diabetes, according to the study of "Efficacy of high-fiber diets in the management of type 2 diabetes mellitus" by Wolfram T, Ismail-Beigi F., posted pubMed(2).
3. High blood pressure, heart disease and stroke
As we mention in the previous article, high levels of magnesium reduces the risk of blood clot by dilating blood vessels, according to the study of "Magnesiumcauses nitric oxide independent coronary artery vasodilation in humans" by Teragawa H, Kato M, Yamagata T, Matsuura H, Kajiyama G., posted in PubMed(3), thus decreasing the risk of high blood pressure, heart disease and stroke.
4. Cholesterol Levels
Whole wheat contains plant sterols and stanols which are proven to be effective in slowing the progression of atherosclerosis by reserving atherosclerosis naturally caused by cholesterol builds up the plaques inside the arteries, leading arteries clogged, resulting in cardiovascular diseases, according to the study of "New insights into the molecular actions of plant sterols and stanols in cholesterolmetabolism" by Calpe-Berdiel L, Escolà-Gil JC, Blanco-Vaca F., posted in PubMed(4).
5. Breast cancer
High levels of lignan in whole wheat acts as antioxidant that improves the immune function in fighting against irregular cell growth, thus reducing the risk of cancer, according to the study of " Avemar, a nontoxic fermented wheat germ extract, attenuates the growth of sensitive and 5-FdUrd/Ara-C cross-resistant H9 human lymphoma cells through induction of apoptosis"byAgarwal RP, Grusch M, Hidvégi M, Jaeger W, Krupitza G, Lackner A, Madlener S, Ozsvar-Kozma M, Saiko P, Szekeres T, Fritzer-Szekeres M, Graser G posted in Journal: Oncology Reports Release date: 2009 (5), researchers found that Avemar exerts a number of beneficial effects which could support conventional chemotherapy of human malignancies.
6. Etc.
Side effects
1. Gliadin in whole wheat can weaken the immune system, leading to inflammation.
2. Wheat allergy.
3. Oxalates
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Sources
(a) http://www.ncbi.nlm.nih.gov/pubmed/20444273
(b) http://www.ncbi.nlm.nih.gov/pubmed/20980650
(c) http://www.ncbi.nlm.nih.gov/pubmed/22035073
(d) http://www.ncbi.nlm.nih.gov/pubmed/21901116
(I) http://www.ncbi.nlm.nih.gov/pubmed/22072339
(II) http://www.ncbi.nlm.nih.gov/pubmed/20713332
(III) http://www.ncbi.nlm.nih.gov/pubmed/19539268
(IV) http://www.ncbi.nlm.nih.gov/pubmed/21951617
1. http://www.ncbi.nlm.nih.gov/pubmed/20420203
2. http://www.ncbi.nlm.nih.gov/pubmed/20713332
3. http://www.ncbi.nlm.nih.gov/pubmed/114548464.http://www.ncbi.nlm.nih.gov/pubmed/18692849
5. http://www.avemar.com/for_medical_professionals/48
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