Medical Advisor Journals

Thursday, June 2, 2016

Most common Diseases of 50plus: The Obesity' Research and Studies of Green tea on weight maintenance

You can calculate your BMI index BMI= weight (kg)/ height (m2)

The Research and Studies of Green tea on weight maintenance

In the investigation of whether green tea may improve weight maintenance by preventing or limiting weight regain after weight loss of 5 to 10 % in overweight and moderately obese subjects. A randomised, parallel, placebo-controlled design, conducted by Maastricht University (1). A total of 104 overweight and moderately obese male and female subjects (age 18-60 years; BMI 25-35 kg/m(2)) participated. The study consisted of a very-low-energy diet intervention (VLED; 2.1 MJ/d) of 4 weeks followed by a weight-maintenance period of 13 weeks in which the subjects received green tea or placebo. The result showed that in the green tea treatment, habitual high caffeine consumption was associated with a higher weight regain compared with habitual low caffeine consumption (39 (sd 17) and 16 (sd 11) %, respectively; P<0.05).

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

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(1) "Effects of green tea on weight maintenance after body-weight loss" by Kovacs EM, Lejeune MP, Nijs I, Westerterp-Plantenga MS., posted in PubMed

Most common Diseases of 50plus: Heart Disease(The Articles) - Heart diseases Affecting Heart Valves

Heart Disease

Beside cancer, heart disease kills more than 2,000 Americans everyday. Approximately 60 million Americans have heart disease. There are many causes of heart disease. Anything that serves to damage the inner lining of blood vessels and impedes the transportation of oxygen and nutrition to the heart can be defined as a risk of heart disease.

Heart diseases Affecting Heart Valves

Heart diseases are caused by high blood pressure that contributes to the hardening of the arteries. High levels of bad cholesterol (LDL) build up in the arteries as a result of uncontrolled diet with high levels of saturated fat and trans fat.

Heart diseases affecting heart valves occur when the mitral valve in the heart narrows, causing the heart to work harder to pump blood from the left atrium into the ventricle.

1. Mitral Stenosis
Mitral Stenosis is a heart valve disorder that involves a narrowing or blockage of the opening of the mitral valve causing the volume and pressure of blood in the left atrium increases.

2. Mitral valves regurgitation
Mitral regurgitation is the heart disease in which your heart's mitral valve doesn't close tightly causing the blood to be unable to move through the heart efficiently. Symptoms of mitral valve regurgitation are fatigue and shortness of breath.

3. Mitral valves prolapse
In mitral valve prolapse, one or both leaflets of the valve are too large resulting in uneven closure of the valve during each heartbeat. Symptoms of mitral valves prolapse are palpitation, shortness of breath, dizzy, fatigue and chest pains.

4. Aortic Stenosis
With aging, protein collagen of the valve leaflets are destroyed and calcium is deposited on the leaflets causing scarring, thickening, and stenosis of the valve therefore increasing the wear and tear on the valve leaflets resulting in the symptoms and heart problems of aortic stenosis.

5. Aortic regurgitation
Aortic regurgitation is the leaking of the aortic valve of the heart that causes blood to flow in the reverse direction during ventricular diastole, from the aorta into the left ventricle. Symptoms of aortic regurgitation include fatigue or weakness, shortness of breath, chest pain, palpitation and irregular heart beats.

6. Tricuspid stenosis
Tricuspid stenosis is the narrowing of the orifice of the tricuspid valve of the heart causing increased resistance to blood flow through the valve. Symptoms of tricuspid stenosis include fatigue, enlarged liver, abdominal swelling, neck discomfort and leg and ankle swelling.

7. Tricuspid regurgitation.
Tricuspid regurgitation is the failure of the right ventricular causing blood to leak back through the tricuspid valve from the right ventricle into the right atrium of the heart. Symptoms of tricuspid regurgitation include leg and ankle swelling and swelling in the abdomen.

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

Anti Ageing Tips: Clinical proven in Reduced Visibility of Forehead Fine Lines up to 100%

The α-tocopherol form of vitamin E
The equipment and Preparation
1. One bottle of synthetic vitamin C 100x 500mg tablets. You can purchase this in any pharmacy for about $5.00
2. A bottle of vitamin E purified oil (You can only buy it from any pharmacy for $10) (We used provitamin E produced by Jamieson, due to complaints of irritation and stickiness of many tested subjects, You can also buy it at any pharmacy and super market for about $20 for a jar of 60ml)
2. A small bottle carries 100mL of warm tap water or still-water if desire.
3. A roll of bounty or a half hand size sponge.
4. A pair of plastic glove.

Please Note, Kyle J. Norton and Associates DO NOT receive funding for Jamieson(The giant vitamins company)

How to make Dehydroascorbic acid (DHA) 4% concentration
Day one
Put 8 tablets of synthetic vitamin C into the bottle which carries 100 mL of water[(8x500mg)/100mL=4000mg/100,000mg=4/100=4% concentration ofDehydroascorbic acid (DHA)] on the day before application to make sure all vitamin C tablets are dissolved.

How to reduced visibility of forehead fine lines up to 100%
Fine line is a result of effect of gravity in aging, and causes of slower process in cell rejuvenation and longer in elastic fibers replacement. Some researchers insisted that adding to the aging skin, free radicals and inflammatory molecules may degrade facial skin even quicker.
The next day
Put on your glove. Shake the bottle well. Pour some Dehydroascorbic acid (DHA ) onto a piece of fold-twice bounty paper towels.
Apply the solutions 3 times a days
Application first of Dehydroascorbic acid (DHA) 4% concentration to induce forehead fine line skin cleansing through its detoxified, antioxidant and cell regeneration effects by rubbing against the skin of the effects area with little pressure for about one minutes. Apply more solution if require. Wait for 5 minutes then apply vitamin E directly and generously onto the fine lines for enhancement of cell regeneration and elastic fibers replacement effects.

After applying, clean the sponge if used and glove, return and store the bottle of solution and vitamin E into first aid box in room temperature. Replace the solution of Dehydroascorbic acid (DHA ) every ten days to retain accurate concentration.

What to expect
1. In the first few days of application
Visibility of forehead fine lines shows signs of receding

2. In a few weeks
Depending to types of skin and severity of the effected areas, and according to our clinical study
Up to 100% of forehead fine lines have been removed depending to age, types of skin and severity of the effect areas, according to the study of ages between 57 - 62(Approximately, 5% and 60% of tested-subjects had achieved reduced visibility of 100% and 80% of forehead fine lines after 12 weeks, respectively).

Millions have been spent in our studies, we provide this information free and do not ask for anything in return. You promise to tell everyone you know about this webpage and retweet it, so they do not waste any more money on ineffective commercial products.

Precautions
1. Always testing your topical skin solution, including Dehydroascorbic acid (DHA ) and vitamin E for allergic reaction, by applying a tiny portion onto your wrist for 5 minutes. Do not use the solution if there is.
2. Although there were no adverse effect in our study, please make sure you always wear gloves before applying, as higher concentration than that ofDehydroascorbic acid (DHA) 4% concentration has been shown to cause brownness on the finger nails.
3. The Dehydroascorbic acid (DHA) 4% concentration has been shown to cause yellowness on the surface of some metal (very old) sinks, please make sure your test it to avoid the same messes.
4. Higher concentration of the solution has been used in skin tanning industry, please make that Dehydroascorbic acid (DHA) 4% concentration is completely absorbed(about 5- 10 minutes) into your skin before going to the extreme sun.
5. If the solutions get into your eyes, use tap water to clear them.
6. Do not attempt to make higher than Dehydroascorbic acid (DHA) 4% concentration solution, as it has not been tested.

All articles written by Kyle J. Norton are for information & education only, please consult your Doctor & Related field specialist before applying. If you have any questions about this article, please email at Kylenorton@live.ca

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

References
(a) http://kylejnorton.blogspot.ca/2014/06/dehydroascorbic-acid-dhavitamin-c.html
(b) http://kylejnorton.blogspot.ca/2014/04/skin-aging-in-vitamin-e-points-of-view.html
(c) http://kylejnorton.blogspot.ca/2014/08/vitamin-dehydroascorbic-acid-dha-and.html
(1) http://kylejnorton.blogspot.ca/2014/10/anti-skin-aging-in-dehydroascorbic-acid.html
(2) http://kylejnorton.blogspot.ca/2014/04/skin-aging-in-vitamin-points-of-view.html
(3) http://kylejnorton.blogspot.ca/2014/04/skin-aging-in-vitamin-e-points-of-view.html

Traditional Chinese Medicine Herbal Therapy - Popular Herbal Chinese Herbs – Bai Jiang Can (Bombyx Batryticatus)

2. Localized neurodermatitis (Skin diseases)
Jiang can (Bai Jiang Can, Bombyx Batryticatus) in modified yangxue dingfeng tang (a decoction for nourishing the blood and expelling wind), has exhibited a better and stable effect for the localized neurodermatitis, according to the study of “Treatment of the localized neurodermatitis by plum-blossom needle tapping and with the modified yangxue dingfeng tang–a clinical observation of 47 cases” by Weiying L, Yuanjiang D, Baolian L(2).

3. Lipid peroxidation and protection of antioxidative enzymes.
Bombycis corpus(BC), a is a drug consisting of the dried larva of silkworm has denomstrated the effect against Abeta -induced cytotoxicity in cultured astrocyte cells through the inhibition of lipid peroxidation and protection of antioxidative enzymes, according to the study of “Bombycis corpus extract prevents amyloid-beta-induced cytotoxicity and protects superoxide dismutase activity in cultured rat astrocytes” Kim HJ, Lee WH, Yoon CH, Jeong JC, Nam KS, Kim HM, Choo YK, Lee MC, Kim CH.(3).

4. Ovarian cancer
Bai Jiang Can contains high amount of Asparagine, a chemical compound may be considered for next steps in the development of ASNS as a biomarker for ovarian cancer treatment, according to the study of “Asparagine synthetase: a new potential biomarker in ovarian cancer” by Lorenzi PL, Weinstein JN(4).

5. Anti bacterial and fungal activity
Beauvericin shows the potential use of the endophytic fungus for its biological role in providing its host plant with protection, as well as the possible development of beauvericin as an antibacterial, according to the study of “Beauvericin from the endophytic fungus, Fusarium redolens, isolated from Dioscorea zingiberensis and its antibacterial activity” byXu L, Wang J, Zhao J, Li P, Shan T, Wang J, Li X, Zhou L.(5).

6. Impotent
Dimethyladenosine may be a lead compound of Bai Jiang Can for the development and improvement of vasculogenic impotence drugs through phosphodiesterase inhibition and NO production in endothelial cells., according to the study of “Purification of a dimethyladenosine compound from silkworm pupae as a vasorelaxation substance” by Ahn MY, Shim SH, Jeong HK, Ryu KS.(6).

Side Effects
1. Do not take if you suffer from high blood pressure (not controlled) or have a heart condition(a)
2. Do not take the herb if you are pregnant or breast feeding with out approval of related field specialist.
3. Etc.
Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/12784912
(2) http://www.ncbi.nlm.nih.gov/pubmed/17078443
(3) http://www.ncbi.nlm.nih.gov/pubmed/11207060
(4) http://www.ncbi.nlm.nih.gov/pubmed/19209300
(5) http://www.ncbi.nlm.nih.gov/pubmed/20521553
(6) http://www.ncbi.nlm.nih.gov/pubmed?term=Bombyx%20mori%20L%20and%20impotence%20
(a) http://www.lewtress-health.com/subprod/bombyx-mori-male-aphrodisiac-0003451.aspx

Most common Diseases Free and Longevity of 50 plus - Organic Soy(Whole Food) Part C By Phytochemicals in Foods - Genistein

Over the years of research, 4 foods appeared mostly in medical studies in preventing and treating diseases, are Green Tea, Grape seed and skin, Turmeric and Organic Soy(Not for Western Women). All Right Reserved.

IV. Organic Soy
Soy foods, including tofu have been in traditional Chinese diet over thousands of year, according to Chinese literature. The reduced risk of chronic disease in Asian population, including metabolic syndrome such as cardiovascular diseases, obesity and diabetes and lesser menopause symptoms in advanced age, may be aided by eating a lot of soy food accompanied with large portion of vegetables and fruits. Indeed, according to the study, only 10% of women in the East are experience symptoms of menopause in advanced age compared to over 70% of their Western counterparts.
According to Dr. Mark Messina, Ph.D., Soy foods contributed from 6.5%8 to 12.8%7 of total protein intake in older adult in Japan.(b)

The approval of cardiovascular benefit of soy by FDA in 1999 accompanied with the discovery of health benefits in clinical studies over past decade, prompted the promotion and advertisement of soy's health benefits in every aspect in Western society. Evidences could be seen by walking through the supermarkets and drug stores. Soy supplements and products such as tofu, soy milk, soy-based infant formula, and meatless “texturized vegetable protein” burgers were widely available. According to the United Soybean Board’s 2004–2005, 25% of Americans consumed soy foods or beverages at least once per week, and 74% viewed soy products as healthy.

Today, the promotion of soy is no longer existed, it may be results of discovery of adverse effects in single ingredient and animal studies, as intake of soy is associated to induce risk of certain mammary cancers and infertility. The publication of the result have drawn many criticisms. According to Thomas Badger, director and senior investigator at the Arkansas Children’s Nutrition Center in Little Rock, these effects are seen only under certain experimental conditions that are not likely to occur in humans—and therein lies the crux of the debate(a).Equol (4',7-isoflavandiol), an isoflavandiol metabolized from daidzein may be the causes, as 90% of Eastern population are equol producers but only 30% in the West.
The explanation of the positive effect of soy isoflavones in reduced risk of mammary cancers by University of Goettingen may be interesting, as researchers said" Most importantly, there is dispute as to whether isoflavones derived from soyor red clover have negative, positive or any effect at all on the mammary gland or endometrium. It is beyond any doubt that soy products may have cancerpreventing properties in a variety of organs including the mammary gland. However, these properties may only be exerted if the developing organ was under the influence of isoflavones during childhood and puberty".

Soybean is genus Glycine, the family Fabaceae, one of the legumes that contains twice as much protein per acre as any other major vegetable or grain crop, native to Southeast Asia. Now, it is grown worldwide with suitable climate for commercial profit and a a healthy foods.

Nutrients
1. Carbohydrates
2. Dietary fiber
3. Fat
4. Protein
5. Essential amino acid
6. Vitamin A
7. Vitamin B6
8. Vitamin B12
9. Vitamin C
10. Vitamin K
11. Calcium
12. Iron
13. Magnesium
14. Phosphorus
15. Potassium
16. Sodium
17. Zinc
18. Etc.
Phytochemicals
1. Isoflavones
2. Genistein
3. Saponins
4. Beta-sitosterol
5. Daidzein

D. By Phytochemicals in Foods - Genistein

Genistein is a phytochemical in the Isoflavones, belonging to the group of Flavonoids (polyphenols), found abundantly in food of the family of legumes, soy, alfalfa sprouts, red clover, chickpeas, peanuts, etc.
1. Bladder Cancer
In a phase 2 randomized, placebo-controlled trial investigated whether daily, oralgenistein (300 or 600 mg/day as the purified soy extract G-2535) for 14-21 days before surgery alters molecular pathways in bladder epithelial tissue in 59 subjects diagnosed with urothelial bladder cancer (median age 71), found that G-2535 treatment was well tolerated; observed toxicities were primarily mild to moderate gastrointestinal or metabolic and usually not attributed to study drug. Genisteinwas detected in plasma and urine of subjects receiving G-2535 at concentrations greater than placebo subjects' but were not dose-dependent. Reduction in bladder cancer tissue p-EGFR staining between the placebo arm and the combinedgenistein arms was significant at the protocol-specified significance level of 0.10 (p=0.07), according to "A Phase 2 Cancer Chemoprevention Biomarker Trial of Isoflavone G-2535 (Genistein) in Presurgical Bladder Cancer Patients" byMessing E, Gee JR, Saltzstein DR, Kim K, Disant'agnese PA, Kolesar J, Harris L, Faerber A, Havighurst TC, Young JM, Efros M, Getzenberg RH, Wheeler MA, Tangrea J, Parnes HL, House M, Busby JE, Hohl RJ, Bailey HH.(1)

2. Immunomodulation And Anti-Inflammation
In the review of new concepts have emerged in relation to mechanisms that contribute to the regulation of carcinogenesis processes and associated inflammatory effects, found that the effects of polyphenols on the adaptative and innate immune cells that could infiltrate the tumor. Reduction of chronic inflammation or its downstream consequences may represent a key mechanism in the fight of cancer development and polyphenols could reduce various pro-inflammatory substance productions through targeting signal transduction or through antioxidant effects, according to "Immunomodulation And Anti-Inflammatory Roles Of Polyphenols As Anticancer Agents" by Ghiringhelli F, Rébé C, Hichami A, Delmas D.(2)

3. Bone density
In the investigation of the association between habitual phyto-oestrogen intake and broadband ultrasound attenuation (BUA) of the calcanaeum as a marker of bone density, found that the non-soya isoflavones formononetin and biochanin A were marginally significant or significantly associated with BUA in postmenopausal women (β = 1·2; P < 0·1) and men (β = 1·2; P < 0·05), respectively; enterolignans and equol were positively associated with bone density in postmenopausal women, but this association became non-significant when dietary Ca was added to the model. In the lowest quintile of Ca intake, soya isoflavones were positively associated with bone density in postmenopausal women (β = 1·4; P < 0·1), according to "Association between dietary phyto-oestrogens and bone density in men and postmenopausal women" by Kuhnle GG, Ward HA, Vogiatzoglou A, Luben RN, Mulligan A, Wareham NJ, Forouhi NG, Khaw KT.(3)

4. Antioxidant effects
In the testing effects of the soy isoflavone genistein on antioxidant enzymes in DU145 prostate cancer cells, found that Genistein significantly decreased reactive oxygen species levels and induced the expression of the antioxidant enzymes manganese (Mn) superoxide dismutase (SOD) and catalase, which were associated with AMP-activated protein kinase (AMPK) and phosphatase and tensin homolog deleted from chromosome 10 (PTEN) pathways. The induced expression of catalase, MnSOD, and PTEN were attenuated by pretreatment with a pharmacological inhibitor for AMPK. Furthermore, PTEN is essential forgenistein activity, as shown by PTEN transfection in PTEN-deficient PC3 cells. Thus, genistein induces antioxidant enzymes through AMPK activation and increased PTEN expression. indicating the effects of genistein primarily depend on AMPK, according to "The antioxidant effects of genistein are associated with AMP-activated protein kinase activation and PTEN induction in prostate cancer cells" by Park CE, Yun H, Lee EB, Min BI, Bae H, Choe W, Kang I, Kim SS, Ha J.(4)

5. Anti cancers
In the determination of Genistein, the predominant isoflavones found in soy, has been shown to inhibit the carcinogenesis in animal models, indicated that there are growing body of experimental evidence that show the inhibition of human cancer cells by genistein through the modulation of genes that are related to the control of cell cycle and apoptosis. Moreover, it has been shown that genistein inhibits the activation of NF-kappa B and Akt signaling pathways, both of which are known to maintain a homeostatic balance between cell survival and apoptosis. Genistein is commonly known as phytoestrogen, which targets estrogen- and androgen-mediated signaling pathways in the processes of carcinogenesis, according to"Soy isoflavones and cancer prevention" by Sarkar FH, Li Y.(5)

6. Prostate cells
In the investigation of the hypothesis that the soy-isoflavone genistein could protect DNA of LAPC-4 prostate cells from oxidative stress-related damage by enhancing the expression of antioxidative genes and proteins, found that genisteinprotects prostate cells from oxidative stress-related DNA damage presumably by inducing the expression of antioxidative products, such as metallothioneins.Genistein, therefore, might counteract the age-related decline of important antioxidative defence systems which in turn maintain DNA integrity, according to "Genistein protects prostate cells against hydrogen peroxide-induced DNA damage and induces expression of genes involved in the defence against oxidative stress" by Raschke M, Rowland IR, Magee PJ, Pool-Zobel BL(6)

7. Breast cancer
In the investigation of the potential preventive effects of lycopene and genistein, alone and in combination, on breast cancer development in female Wistar rats treated with 7,12-dimethylbenz[a]anthracene (DMBA), a carcinogen known to induce breast tumors.
found that treatment was continued for 20 wk. Rats treated with DMBA developed mammary tumors with 100% tumor incidence during the 20-wk study. Inhibition of mammary cancer incidence by lycopene (70%), genistein (60%) and their combination (40%) was observed. Tumor weight decreased by 48%, 61%, and 67%, and mean tumor volume decreased by 18%, 35%, and 65% with lycopene,genistein, and lycopene + genistein, respectively (P < 0.01 for the combination). The proportions of adenocarcinoma masses decreased with lycopene andgenistein combination (P < 0.05). Administration of lycopene and genisteincombination suppressed breast cancer development and was associated with a decrease in MDA, 8-isoprostane, and 8-OhdG levels and with an increase in serum lycopene and genistein levels. Animals administered DMBA developed breast cancer, which was associated with increased expression of Bcl-2 and decreased expression of Bax, caspase 3, and caspase 9 in mammary tissues, according to "Inhibitory effects of combination of lycopene and genistein on 7,12- dimethyl benz(a)anthracene-induced breast cancer in rats" by Sahin K, Tuzcu M, Sahin N, Akdemir F, Ozercan I, Bayraktar S, Kucuk O.(7)

8. Neuroprotective effects
in the investigation of whether GEN could alleviate oxidative damage induced by beta-amyloid peptides 25-35 (Abeta25-35) in PC12 cells, found that GEN attenuated the cytotoxicity and partially prevented apoptosis induced by Abeta25-35. GEN dramatically attenuated ROS levels induced by Abeta25-35 in PC12 cells. In addition, GEN significantly reversed the reduction of MMP caused by Abeta25-35 to maintain the normal levels of the cells. The GSH/GSSG ratio in GEN pretreated groups significantly increased compared to the groups without GEN pretreatment. GEN reversed Abeta25-35 induced down regulation of the protein expression of gamma-GCS, Nrf2 and HO-1, according to "Genistein as a neuroprotective antioxidant attenuates redox imbalance induced by beta-amyloid peptides 25-35 in PC12 cells" by Ma W, Yuan L, Yu H, Ding B, Xi Y, Feng J, Xiao R.(8)

9. Anti diabetes
In the investigation of the effect of genistein on beta-cell proliferation and cellular signaling related to this effect and further determined its antidiabetic potential in insulin-deficient diabetic mice, found that genistein induced protein expression of cyclin D1, a major cell-cycle regulator essential for beta-cell growth. Dietary intake of genistein significantly improved hyperglycemia, glucose tolerance, and blood insulin levels in streptozotocin-induced diabetic mice, concomitant with improved islet beta-cell proliferation, survival, and mass. These results demonstrate thatgenistein may be a natural antidiabetic agent by directly modulating pancreatic beta-cell function via activation of the cAMP/PKA-dependent ERK1/2 signaling pathway, according to "Genistein induces pancreatic beta-cell proliferation through activation of multiple signaling pathways and prevents insulin-deficient diabetes in mice" by Fu Z, Zhang W, Zhen W, Lum H, Nadler J, Bassaganya-Riera J, Jia Z, Wang Y, Misra H, Liu D.(9)

10. Bone homeostasis
In the deiermination of the effect of genistein on bone homeostasis in mandibular subchondral bone of rats.Methods:Female SD rats were administered withgenistein (10 and 50 mg/kg) or placebo by oral gavage for 6 weeks, found that the low and high doses of genistein significantly increased the expression of ERβ, while ERα expression was increased by the low dose genistein and decreased by the high dose genistein. ERβ silencing abrogated most of the effects of genisteintreatment.Conclusion:In rat mandibular condylar subchondral bone, low-dosegenistein increases bone formation and inhibit bone resorption, while excessgenistein inhibits both bone formation and resorption, according to"Dose-dependent effects of genistein on bone homeostasis in rats' mandibular subchondral bone" by
Li YQ, Xing XH, Wang H, Weng XL, Yu SB, Dong GY.(10)

11. Obesity
In the study of the role of ER alpha and ER beta in a model of nutrition induced obesity, found that Treatment with E2 and Alpha decreased body weight, total cholesterol and VLDL. Visceral fat mass, adipocyte size, and serum leptin were reduced by E2, Alpha and Beta. In the soleus muscle, treatment with E2 and Beta modulated Igf1 and Pax7 gene expression and resulted in larger muscle fibers, according to "Impact of estradiol, ER subtype specific agonists and genisteinon energy homeostasis in a rat model of nutrition induced obesity" by
Weigt C, Hertrampf T, Zoth N, Fritzemeier KH, Diel P.(11)

Etc.

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/22293631
(2) http://centaur.reading.ac.uk/20335/
(3) http://www.ncbi.nlm.nih.gov/pubmed/22292769
(4) http://www.ncbi.nlm.nih.gov/pubmed/20673057
(5) http://www.ncbi.nlm.nih.gov/pubmed/21736835
(6) http://www.ncbi.nlm.nih.gov/pubmed/14628433
(7) http://www.ncbi.nlm.nih.gov/pubmed/21958026
(8) http://www.ncbi.nlm.nih.gov/pubmed/20362658
(9) http://www.ncbi.nlm.nih.gov/pubmed/20484465
(10) http://www.ncbi.nlm.nih.gov/pubmed/22120966
(11) http://www.ncbi.nlm.nih.gov/pubmed/22230815

General Health: Candida Albicans: Treatment in Chinese Herbs for Lower and Middle burner causes of Candida Albicans Overgrowth

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

What is Candida Albicans
Candida albicans are members of a large group of micro organism whose cells contain complex structures enclosed within the membranes, including yeast(2)(3), fungi(4)(5)(6), and mold(6) that live among the gut flora in the human mouth and gastrointestinal tract. In fact, under normal circumstances, Candida albicans that do not cause harmful effects, but overgrowth results in candidiasis. Non-albicansCandida (NAC) species cause 35-65% of all candidaemias in the general patient population(1). According to joint study, in many cases, biofilm(microorganisms with cells stick to each other on a surface) formation(7) gene mutations(8) and overexpression of genes(9)(10) are often associated with increased Candidaresistance toward antifungal agents.

Treatment

In Traditional Chinese Medicine
In traditional Chinese medicine, candidiasis is defined as a malfunction of the Triple Burner-related condition due to spleen and stomach disorder(401), causing excess fluid or phlegm in our system(402), weakening immune system(403)(402), leading to damp heat accumulates in the Lower, Middle and Upper Burner causes of candidiasis(401).

Cleansing TCM Herbs

Overgrowth of candida in TCM is considered as the accumulation of waste, phlegm and damp heat, toxins due to inability of spleen and stomach in digesting foods properly(401).
Chinese Herbs for Lower and Middle burner causes of Candida Albicans Overgrowth
1. Long Dan Cao (Gentianae Radix)
Long can cao is also known as Gentian is a genus of flowering plants (Gentiana L),belonging to the family Gentianaceae. The bitter, cold and non toxic herb has been used in TCM as analgesic(407) and to treat inflammation(404)(406), stimulate the digestive system(407)(408), in regulation of production of bile(409)(411), hydrochloride acid(411)(413) and other digestive enzymes secretion from panceas(414) by clearing liver and gallbladder damp heat(419) as it enhances the functions of liver, gallbladder and stomach channels(410)(412). According to study, the herb contains 5 active iridoids (loganic acid, 6'-O-beta-D-glucopyranosylgentiopicroside, swertiamarin, gentiopicroside, sweroside)(405), responsible for some of pharmaceutical activities, including cardiovascular, antihepatotoxic, choleretic, hypoglycemic, analgesic, anti-inflammatory,..... activities(406).
According to The University of Hong Kong, Long gan cao showed effectively in inhibition of Streptococcus mitis, Streptococcus sanguis, Streptococcus mutans and Porphyromonas gingivalis, through its anti microbial activities(418)

2. Huang Qin (Skullcap)
Huang qin is also known as skullcap, a genus of Scutellaria, belonging to the family Lamiaceae. The bitter and cold herb has been used in TCM as antihistamine(415), anti edema(415) and anti-toxin(415) agents and to promote bowel movements(416), treat hepatitis B(417) by clearing heat(419), drying fire, draining dampness(419) as it promotes the functions of gallbladder, large intestine, lung, stomach channels. According to Integrating Complementary Medicine into Veterinary Practice By Paula Jo Broadfoot, Richard E. Palmquist, Karen Johnston, Jiu Jia Wen, Barbara Fougere, skullcap exhibited anti inflammatory, anti allergic, anti microorganisms effects(419), probably through its antioxidant and stimulating immune activities(420).

3. Zhi Zi (Gardenia)
Zhi zi is also known as gardenia fruit, a genus of Gardenia, belonging to the family Rubiaceae, native to the tropical and subtropical regions of Africa, southern Asia,Australasia and Oceania. The bitter, cold and toxic herb has been used in TCM as anti toxic and antimalarial(421) antibiotic, antibacterial (424) antithrombotic(423), including resistant bacteria carrying blaNDM-1 and Candida albicans(426) and anti-inflammatory(421) effects and to treat digestive disorder(425) by dispersing fire, clearing heat, draining dampness, expelling toxins as it enhances the functions of heart, liver, lung, stomach, triple warmer channels.

4. Mu Tong (Akebia caulis)
Mu Tong is also known as Akebia caulis, a genus of akebia, belonging to the family Lardizabalaceae. The bitter and cool herb has been used in TCM as antibiotic, (Including inhibition of a variety of pathogenic fungi, including candida albicans(428)) anti-tumor, anti-inflammatory(429), a diuretic(430) and a pain reliever agent(427)(429) and to calm pain on urination(428)(429) and clearing heat as it promotes the functions of bladder, heart, small intestine channels(428).

5. Che Qian Cao (Plaintain)
Che qian cao is also known as Plaintain, the common name for herbaceous plants of the genus Musa, native to Southeast Asia and Oceania. The sweet and cold herb has been used in TCM as antimicrobials agent(431)(432) and to promote intestinal health, by blocking adhesion of intestinal pathogens(433), probably through its antioxidant(436) and Immunomodulatory(437) effects, treat damp heat in the lower burner channel(439) due to infection(431)(434)and sexual dysfunction(435), stop diarrhea(438) by clearing the liver and lungs and transforming phlegm as it promotes the functions of bladder, kidney, liver, lung channels(439).

6. Ze Xie (Alismatis Rhizoma)
Ze xie is also known as Alisma, a genus of flowering plants in the family Alismataceae, found in a variety of still water habitats all over the world. The sweet and cold herb has been used in TCM as antioxidant(450) agent and to treat painful and difficult urination, edema, atopic dermatitis(445), nephropathy, hypoglycemica(446), diabetes(449), inflammation(441)(444), diarrhea(442), leukorrhagia(443), caused by damp heat in the lower burner(440), by eliminating water(441), clearing heat and damp heat as its enhances the functions of kidney and bladder channels(440).
According to Shanghai University of Traditional Chinese Medicine, herbal formula Jianpi Huoxue Decoction, containing ze xie, effectively improved intestinal permeability by allowing nutrients to pass through the gut, while blocking potentially toxins from entering(448).

7. Chai Hu (Radix Bupleuri)
Chai hu is also known as Buplerum, a genus Buplerum of plants of the Apiaceae family. The bitter and cold herd has been used in TCM as anthelmintic(453)(456), anti proliferative(456), antimicrobial(459) and anti stress(455) agent and to treat fever, cold, hepatitis(451), diabetes(452), irregular menses(59), prolapse of uterus(459), and prolapse of rectum(459) by clearing heat and resolving depression(457) and liver stagnation(458) as it promotes the functions of the liver, gallbladder, pericardium, triple burner channels.
According to studies, the herb also process a very strong antioxidant contents through its total phenolic compounds including B. falcatum, B. falcatum 'Mishima' and B. latissimum, via radical scavenging activity(454).

8. Etc.

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References
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(411) Active constituents of Gentian.Radix Gentianae.Gentian root(MDidea)
(412) long dan cao(Complementary and Alternative Healing University)
(413) Influence of d-galactosamine hydrochloride on lipids and their fatty acidcomposition in plasma and liver of guinea pigs by Gallenkamp H, Bartsch GG, Löhr JP, Brachtel D, Richter E.(PubMed)
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(415) Huang Qin (Complementary and Alternative Healing University)
(416) Felter, H.W. The Eclectic Materia Medica, Pharmacology and Therapeutics. Cincinnati, Ohio: John K. Scudder, 1922, p. 625.
(417) Skullcap(University of Maryland medical center)
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(427) Akebia - Ask Dr. Mao
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[Article in Spanish] by Bernal C1, Alcaraz GM, Botero JE.(PubMed)
(439) Che Qian Cao (Complementary and Alternative Healing University)
(440) Ze Xie (Complementary and Alternative Healing University)
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(442) 间明中药学 By Eric Brand, Nigel Wiseman. Page 509
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(446) Study on the hypoglycemic activities and metabolism of alcohol extract ofAlismatis Rhizoma by Li Q1, Qu H.(PubMed)
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(451) Saikosaponin a, an active compound of Radix Bupleuri, attenuates inflammation in hypertrophied 3T3-L1 adipocytes via ERK/NF-κB signaling pathways by Kim SO1, Park JY1, Jeon SY1, Yang CH2, Kim MR1.(PubMed)
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(456)Antioxidant and Proliferative Activities of Bupleuri Radix Extract Against Serum Deprivation in SH-SY5Y Cells by Seo MK1, Cho HY, Lee CH, Koo KA, Park YK, Lee JG, Lee BJ, Park SW, Kim YH.(PubMed)
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(459) Chai Hu(Complementary and Alternative Healing University)

Most common Diseases of 50plus: The Obesity' Article of Phytochemical Triterpenoid and Non alcoholic Fatty liver disease

The Obesity' Article of Phytochemical Triterpenoid and Non alcoholic Fatty liver disease

Triterpenoid is a various unsaturated hydrocarbons, found in essential oils and oleoresins of plants, including Ilex hainanensis Merr.

Non-alcoholic Fatty Liver Disease is defined as a condition of the fatty liver diseases as a result of accumulated of fat in the liver, not caused by abusive alcohol consumption.

Progression of nonalcoholic steatohepatitis (NASH) to Non alcoholic liver disease is inevitable if left untreated. Ilex hainanensis Merr. is the Chinese herb used to treat for hypertension, dyslipidemia and inflammation in Traditional Chinese Medicine (TCMs) and may be a potential medicine to treat Non alcoholic fatty disease. In the study to test the effect of Triterpenoid-rich fraction (TP) from Ilex hainanensis Merr. on NAFLD with Male Sprague-Dawley (SD) rats fed a normal diet (control) or high fat diet (NAFLD model), after 4 weeks, the high fat diet group was orally administrated TF (250 mg/kg) for another two weeks. TP not only improves the symptoms of the subjects, but also decreases the levels of triglyceride , total cholesterol, low-density lipoprotein cholesterol, abnormality of lipid accumulation , levels of inflammation and infection and apoptosis response in the liver. Of these results, TF is found to be effective in protecting liver againstNAFLD by regulating lipids metabolism and alleviating insulin resistance, inflammation and oxidative stress.

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Reference
(1) Pharmacokinetic study of major bioactive components in rats after oral administration of extract of Ilex hainanensis by high-performance liquid chromatography/electrospray ionization mass spectrometry by Jie Yanga, 1, Fang Lva, 1, Xiao-qing Chenb, Wei-xi Cuia, Li-hong Chenc, Xiao-dong Wena, Qiang Wanga(Science direct)
(2) Triterpenoid-rich fraction from Ilex hainanensis Merr. attenuates non-alcoholic fatty liver disease induced by high fat diet in rats by Cui WX, Yang J, Chen XQ, Mao Q, Wei XL, Wen XD, Wang Q.(PubMed)