Medical Advisor Journals

Thursday, June 2, 2016

Phytochemicals In Foods: The effects of Omega-3, 6,9 fatty acids

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Omega-3, 6,9 fatty acids

Omega-3, 6,9 fatty acids are phytochemincals in the class of Lipids, found abundantly in dark-green leafy vegetables, grains, legumes, nuts, etc.

Health Benefits
1. Vascular smooth muscle tone
In the investigation of the comparative effects of omega-3, omega-6 and omega-9fatty acids on vascular smooth muscle tone, showed that Docosahexaenoic acid (1-255 microM) and eicosapentaenoic acid (31-255 microM) inhibited phenylephrine-induced contractions, (8-63%) and (20-65%), respectively, which were not altered by indomethacin, NDGA, or by removal of the endothelium. Linoleic acid (18:2n6) and arachidonic acid (20:4n6) also induced significant relaxation. Therefore, fatty acid-induced relaxation of the rat aorta is specific to polyunsaturated fatty acids, 20:5n3, 22:6n3, 18:2n6 and 20:4n6, according to "Effects of omega-3, omega-6 and omega-9 fatty acids on vascular smooth muscle tone" by Engler MB.(1)

2. Breast cancer
In the review of the literature concerning the role of fatty acids and eicosanoid synthesis inhibitors in breast carcinoma, indicated that The omega-6 polyunsaturated fatty acids (PUFAs), primarily linoleic acid, promote breast cancer tumorigenesis and tumor cell proliferation directly and indirectly via increased synthesis of cyclooxygenase- and lipoxygenase-catalyzed products. The omega-3PUFAs, primarily docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), suppress breast carcinoma tumorigenesis and tumor cell proliferation, although the effect of DHA may be partly ascribed to increased amounts of EPA derived from DHA. Both cyclooxygenase and lipoxygenase inhibitors suppress tumorigenesis and/or tumor proliferation, with the latter being more active. Thus, arachidonic acid-derived eicosanoids play an important role in breast cancer, and the balance of the various eicosanoids may be a critical determinant of cell proliferation, according to "The role of fatty acids and eicosanoid synthesis inhibitors in breast carcinoma" by Noguchi M, Rose DP, Earashi M, Miyazaki I.(2)

3. Regulatory effects
In the examination of the effects of individual n-6 (linoleic acid) and n-3 (alpha-linolenic, eicosapentaenoic, and docosahexaenoic acid) PUFAs on plasma lipid levels and on the major transport processes that determine plasma LDL concentrations, found that Rats were fed a semisynthetic cholesterol-free diet supplemented with 4% (by wt) linoleic, alpha-linolenic, eicosapentaenoic, or docosahexaenoic acid for 2 weeks. Dietary eicosapentaenoic and docosahexaenoic acids lowered plasma triglyceride concentrations by 62% and 52%, respectively, and lowered plasma cholesterol concentrations by 54% and 43%, respectively. In contrast, dietary linoleic and alpha-linolenic acids had relatively little effect on plasma triglyceride or cholesterol concentrations. Dietary eicosapentaenoic and docosahexaenoic acids increased hepatic LDL receptor activity by 72% and 58%, respectively, and reduced the rate of LDL cholesterol entry into plasma by 36% and 30%, respectively, according to "Regulatory effects of individual n-6 and n-3 polyunsaturated fatty acids on LDL transport in the rat" by Spady DK.(3)

4. Systolic blood pressure, triglycerides and LDL cholesterol
In the ccomparison of the cardiovascular risk-reduction potential of three major polyunsaturated fatty acids in a double-blind study. showed that for the diet supplemented with EPA plus DHA compared with the linoleic acid diet systolic blood pressure fell 5.1 mm Hg (p = 0.01); plasma triglyceride and VLDL cholesterol fell by 39% (p = 0.001) and 49% (p = 0.01), respectively; and LDL cholesterol rose by 9% (p = 0.01). There were no significant changes with the diet supplemented with alpha-linolenic acid. The net effect on cardiovascular risk therefore is complex and the systolic blood pressure reduction was substantial, according to "n-3 fatty acids of marine origin lower systolic blood pressure and triglycerides but raise LDL cholesterol compared with n-3 and n-6 fatty acids from plants" by Kestin M, Clifton P, Belling GB, Nestel PJ.(4)

5. Cardiovascular effects
In the comparison of the effects of alpha-linolenic acid (ALA, C18:3n-3) to those of eicosapentaenoic acid (EPA, C20:5n-3) plus docosahexaenoic acid (DHA, C22:6n-3) on cardiovascular risk markers in healthy elderly subjects, found that Both n-3fatty acid diets did not change concentrations of total-cholesterol, LDL-cholesterol, HDL-cholesterol, triacylglycerol and apoA-1 when compared with the oleic acid-rich diet. However, after the EPA/DHA-rich diet, LDL-cholesterol increased by 0.39 mmol/l (P = 0.0323, 95% CI (0.030, 0.780 mmol/l)) when compared with the ALA-rich diet. Intake of EPA/DHA also increased apoB concentrations by 14 mg/dl (P = 0.0031, 95% CI (4, 23 mg/dl)) and 12 mg/dl (P = 0.005, 95% CI (3, 21 mg/dl)) versus the oleic acid and ALA-rich diet, respectively. Except for an EPA/DHA-induced increase in tissue factor pathway inhibitor (TFPI) of 14.6% (P = 0.0184 versus ALA diet, 95% CI (1.5, 18.3%)), changes in markers of hemostasis and endothelial integrity did not reach statistical significance following consumption of the two n-3 fatty acid diets, according to "Effects of alpha-linolenic acid versus those of EPA/DHA on cardiovascular risk markers in healthy elderly subjects" by Goyens PL, Mensink RP.(5)

6. Cognitive effects
In the assessment of the cognitive effects of fish oil supplementation at college age, hypothesizing benefits on affect, executive control, inhibition, and verbal learning and memory. College-aged participants, indicated that the benefits of n-3 PUFA on RAVLT performance derived more from depreciated placebo performance than improved performance due to fish oil. The placebo gain on TMT performance likely derived from a learning effect. Together, these results present limited cognitive benefits of n-3 PUFA at college age; however, the treatment may have been subtherapeutic, with a larger sample needed to generalize these results, according to "Omega-3 polyunsaturated fatty acids and cognition in a college-aged population" by Karr JE, Grindstaff TR, Alexander JE.(6)

7. Depression-related cognition
In the investigation of the effects of n-3 PUFA on depression-relevant cognitive functioning in healthy individuals, found that The n-3 PUFA group made fewer risk-averse decisions than the placebo group. This difference appeared only in non-normative trials of the decision-making test, and was not accompanied by increased impulsiveness. N-3 PUFAs improved scores on the control/perfectionism scale of the cognitive reactivity measure. No effects were found on the other cognitive tasks and no consistent effects on mood were observed. The present findings indicate that n-3 PUFA supplementation may have a selective effect on risky decision making in healthy volunteers, which is unrelated to impulsiveness, according to "Omega-3 fatty acids (fish-oil) and depression-related cognition in healthy volunteers" by Antypa N, Van der Does AJ, Smelt AH, Rogers RD.(7)

8. Mental illness
In the review of the double blind placebo controlled clinical trials published prior to April 2007 to determine whether omega-3 PUFA are likely to be efficacious in these psychiatric disorders, found that for schizophrenia and borderline personality disorder we found little evidence of a robust clinically relevant effect. In the case of attention deficit hyperactivity disorder and related disorders, most trials showed at most small benefits over placebo. A limited meta-analysis of these trials suggested that benefits of omega-3 PUFA supplementation may be greater in a classroom setting than at home. Some evidence indicates that omega-3 PUFA may reduce symptoms of anxiety although the data is preliminary and inconclusive. The most convincing evidence for beneficial effects of omega-3PUFA is to be found in mood disorders. A meta-analysis of trials involving patients with major depressive disorder and bipolar disorder provided evidence that omega-3 PUFA supplementation reduces symptoms of depression. Furthermore, meta-regression analysis suggests that supplementation with eicosapentaenoic acid may be more beneficial in mood disorders than with docosahexaenoic acid, although several confounding factors prevented a definitive conclusion being made regarding which species of omega-3 PUFA is most beneficial, according to "Omega-3 fatty acids as treatments for mental illness: which disorder and which fatty acid?" by Ross BM, Seguin J, Sieswerda LE.(8)

9. Antioxidant, antimicrobial activities
In the investigation of the hexane extract from different parts in several Hypericum species, found that The antioxidant activity of all hexane extracts was evaluated by the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging method. The results indicate that hexane extracts from different parts of H. scabrum possess considerable antioxidant activity. The highest radical scavenging activity was detected in seed, which had an IC50 = 165 microg/mL. The antimicrobial activity of the extracts of those samples were determined against seven Gram-positive and Gram-negative bacteria (Bacillus subtilis, Enterococcus faecalis, Staphylococcus aureus, S. epidermidis, Escherichia coli, Pseudomonas aeruginosa, and Klebsiella pneumoniae), as well as three fungi (Candida albicans, Saccharomyces cerevisiae, and Aspergillus niger), according to "Antioxidant, antimicrobial activities and fatty acid components of flower, leaf, stem and seed of Hypericum scabrum" by Shafaghat A.(9)

10. Post-partum depression PPD
In the investigation of the effect of unbalanced dietary intake of omega-6/omega-3ratio >9:1 in the prevalence for PPD, comprising a prospective cohort with four waves of follow-up during pregnancy and one following delivery. PPD was evaluated according to the Edinburgh Post-partum Depression Scale (PPD ≥ 11) in 106 puerperae between 2005 and 2007, in Rio de Janeiro, Brazil. Independent variables included socio-demographic, obstetric, pre-pregnancy body mass index (BMI) and dietary intake data, which were obtained by means of a food frequency questionnaire in the first trimester of pregnancy, verified that an association between omega-6/omega-3 ratio above 9:1, the levels recommended by the Institute of Medicine, and the prevalence of PPD. These results add to the evidence regarding the importance of omega-6 and omega-3 fatty acids in the regulation of mental health mechanisms, according to "High dietary ratio of omega-6 to omega-3 polyunsaturated acids during pregnancy and prevalence of post-partum depression" by da Rocha CM, Kac G.(10)

11. Relieving inflammation
In the evaluation of the effects of lymphatic drainage and omega-3 polyunsaturatedfatty acid (omega-3PUFA) on high mobility group box 1 (HMGB1), inflammatory cytokines and endotoxin in rats with intestinal ischemia-reperfusion (I/R) injury, found that Lymphatic drainage may reduce the levels of endotoxin, inflammatory cytokines and HMGB1 so as to alleviate the intestinal I/R injury. The intervention of omega-3PUFA has some protective effect through relieving inflammation, according to "[Effects of lymphatic drainage and omega-3 polyunsaturatedfatty acids on intestinal ischemia-reperfusion injury in rats].[Article in Chinese]" by Zhou KG, He GZ, Zhang R, Chen XF.(11)

12. Suppression of inflammatory
In the determination of whether salmon (rich in n-3 LCPUFAs) consumption twice a week during pregnancy affected offspring umbilical vein EC CAM expression, showed that increased dietary salmon intake in pregnancy dampens offspring EC activation, which implicates a role for n-3 LCPUFAs in the suppression of inflammatory processes in humans. This trial was registered at clinicaltrials.gov as NCT00801502, according to "Salmon consumption by pregnant women reduces ex vivo umbilical cord endothelial cell activation" by van den Elsen LW, Noakes PS, van der Maarel MA, Kremmyda LS, Vlachava M, Diaper ND, Miles EA, Eussen SR, Garssen J, Willemsen LE, Wilson SJ, Godfrey KM, Calder PC.(12)

13. Neonatal immune responses
In thye assessment of whether an increased intake of oily fish in pregnancy modifies neonatal immune responses and early markers of atopy, showed that Oily fish intervention in pregnancy modifies neonatal immune responses but may not affect markers of infant atopy assessed at 6 mo of age, according to "Increased intake of oily fish in pregnancy: effects on neonatal immune responses and on clinical outcomes in infants at 6 mo" by Noakes PS, Vlachava M, Kremmyda LS, Diaper ND, Miles EA, Erlewyn-Lajeunesse M, Williams AP, Godfrey KM, Calder PC.(13)

14. Allergic disease
In the study of the effects of maternal n-3 (PUFA)-rich fish oil supplementation on cord blood (CB) IgE and cytokine levels in neonates at risk of developing allergic disease, found that increasing neonatal n-3 PUFA levels with maternal dietary supplementation can achieve subtle modification of neonatal cytokine levels. Further assessment of immune function and clinical follow-up of these infants will help determine if there are any significant effects on postnatal immune development and expression of allergic disease, according to " Maternal fish oil supplementation in pregnancy reduces interleukin-13 levels in cord blood of infants at high risk of atopy' by Dunstan JA, Mori TA, Barden A, Beilin LJ, Taylor AL, Holt PG, Prescott SL.(14)

15. Mucosal immune function
In the evaluation of if changes in breast milk omega-3 polyunsaturated fatty acid (n-3 PUFA) composition as a result of maternal dietary fish oil supplementation during pregnancy can modify levels of these immunological parameters in breast milk, found that Supplementation with fish oil during pregnancy significantly alters early post-partum breast milk fatty acid composition. omega-3 PUFA levels were positively associated with IgA and sCD14 levels, suggesting a relationship between fatty acid status and mucosal immune function, according to "The effect of supplementation with fish oil during pregnancy on breast milk immunoglobulin A, soluble CD14, cytokine levels and fatty acid composition" by Dunstan JA, Roper J, Mitoulas L, Hartmann PE, Simmer K, Prescott SL.(15)

16. Ventricular arrhythmias and myocardial infarction
In the investigation of the effectiveness of prescription medication containing 90%omega-3 polyunsaturated fatty acids for 6 months on ventricular arrhythmias in patients with myocardial infarction less than a year ago, found that Administration of highly concentration preparation of omega-3 PUFAs for 3 months reduced number of PVCs per day, frequencies of grades 2, 3, 4A, 4B, and high grade PVCs (grades 3 - 5) as a whole. These effects persisted after 6 months of treatment, according to "[Possibilities of a preparation omega-3 polyunsaturatedfatty acids in the treatment of patients with ventricular arrhythmias and myocardial infarction].[Article in Russian]" by Gogolashvili NG, Litvinenko MV, Pochikaeva TN, Vavitova ES, Polikarpov LS, Novgorodtseva NIa.(16)

17. Health effects
In the investigation of the health effects of Perilla frutescens seeds, a good source of polyunsaturated fatty acids (PUFAs), showed that in comparing to other plant oils, perilla seed oil consistently contains the one of the highest proportion ofomega-3 (ALA) fatty acids, at 54-64%. The omega-6 (linoleic acid) component is usually around 14% and omega-9 (Oleic acid) is also present in perilla oil. These polyunsaturated fatty acids are most beneficial to human health and in prevention of different diseases like cardiovascular disorders, cancer, inflammatory, rheumatoid arthritis etc., according to "Health effects of omega-3,6,9 fatty acids: Perilla frutescens is a good example of plant oils" by Asif M.(17)

18. Obesity
in the determination of whether obesity modifies the association between plasma phospholipid polyunsaturated fatty acids (PUFAs) and markers of inflammation and endothelial activation in Multi-Ethnic Study of Atherosclerosis (MESA) participants, found that the modifying effect of obesity on the association of plasma PUFAs with IL-6 and sICAM-1 suggests differences in fatty acid metabolism and may also have implications in dietary fatty acid intake for obese individuals, particularly for linoleic and EPAs. Further study is warranted to confirm and explain the strong associations of dihomo-γ-linolenic acid (DGLA) with inflammatory and endothelial activation markers, according to "Obesity modifies the association between plasma phospholipid polyunsaturated fatty acidsand markers of inflammation: the Multi-Ethnic Study of Atherosclerosis" by Steffen BT, Steffen LM, Tracy R, Siscovick D, Hanson NQ, Nettleton J, Tsai MY.(18)

19. Crohn's disease (CD)
In the investigation of the effects of a nutritionally balanced inflammatory bowel disease nutrition formula (IBDNF) on nutrition status in CD patients, indicate that twenty patients completed the final visit. After 4 months, there was a significant decrease in plasma phospholipid levels of arachidonic acid with increases in eicosapentaenoic acid (EPA) and docosahexaenoic acid. Ten patients had a final EPA concentration of >2%. There was improvement in fat-free and fat mass in patients with final EPA >2% (P = .014 and P = .05). Vitamin D (25-OH) levels improved in all patients (18.5-25.9 ng/mL, P < .001). Those with EPA >2% had significantly lower CDAI (116 ± 94.5 vs 261.8 ± 86.5; P = .005) and higher IBDQ (179.1 ± 26.6 vs 114.6 ± 35.9, P < .001) compared to those with EPA <2%, according to "The effects of an oral supplement enriched with fish oil, prebiotics, and antioxidants on nutrition status in Crohn's disease patients" by Wiese DM, Lashner BA, Lerner E, DeMichele SJ, Seidner DL.(19)

20. Etc.

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The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

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Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

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Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/1396998
(2) http://www.ncbi.nlm.nih.gov/pubmed/7777237
(3) http://www.ncbi.nlm.nih.gov/pubmed/8105015
(4) http://www.ncbi.nlm.nih.gov/pubmed/1971991
(5) http://www.ncbi.nlm.nih.gov/pubmed/16482073
(6) http://www.ncbi.nlm.nih.gov/pubmed/22250656
(7) http://www.ncbi.nlm.nih.gov/pubmed/18583436
(8) http://www.ncbi.nlm.nih.gov/pubmed/17877810
(9) http://www.ncbi.nlm.nih.gov/pubmed/22224301
(10) http://www.ncbi.nlm.nih.gov/pubmed/22136220
(11) http://www.ncbi.nlm.nih.gov/pubmed/22093738
(12) http://www.ncbi.nlm.nih.gov/pubmed/22011457
(13) http://www.ncbi.nlm.nih.gov/pubmed/22218160
(14) http://www.ncbi.nlm.nih.gov/pubmed/12680858
(15) http://www.ncbi.nlm.nih.gov/pubmed/15298564
(16) http://www.ncbi.nlm.nih.gov/pubmed/21942955
(17) http://www.ncbi.nlm.nih.gov/pubmed/21909287
(18) http://www.ncbi.nlm.nih.gov/pubmed/21829163
(19) http://www.ncbi.nlm.nih.gov/pubmed/21775642

The Curable Smoothie for Prevention and Treatment of Reye’s Syndrome Caused by Chicken Pox(Varicella-zoster virus)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.

Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post

Nominated for shorty award over last 4 years

Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The finding of a natural source for treatment of Reye’s Syndrome has been running into many obstacles, many ingredients showed initially with promising result in animal studies have not produced same potentials in large sample size and mutli centers human trials.

Reye’s Syndrome is a condition causes of swelling of liver and brain, affecting mostly children often ages 4 to 12 and almost always associated with a previous viral infection such as influenza (flu), cold, or chicken pox(*).

Reye’s Syndrome caused by chicken pox

The smoothie for Prevention and Treatment of Chickenpox(Varicella-zoster virus)
Yield: 2 servings (about 8 ounces each)
1/2 cup orange
1/2 cup sweet potato
1/2 tomato
1 cup rice milk

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed. Add more green tea drink if needed
3. Serve immediately

Recent studies by some renowned institutions suggested that orange(1), sweet potato(3) and tomato(5) may be the next generation of ingredient extracted from natural sources for reduced risk and treatment of Chicken Pox caused by Varicella-zoster virus.

Chickenpox is a infection infection caused by varicella zoster virus (VZV) of which can lead to extremely itchy blisters all over the body. The disease is is a highly contagious illness and one of the classic childhood diseases.

Herpes zoster or zona is defined as a viral disease with condition of a painful, blistering skin rash on one side of the body. Vitamin C, also known as L-ascorbate is a water soluble vitamin with a chemical structure formula of C6H6O6 found abundantly in orange may be effect for prevention and treatment of shingles. According to the Heart-Jesus Hospital, Dernbach, intravenously administered ascorbic acid may have beneficial effects on herpes zoster-associated pain(1).

Dr. Schencking M and Dr. Kraft K. in the study of vitamin C against shingles suggested, combination of Cantharidin patches and intravenous administration of vitamin C is the best concomitant treatment of herpes zoster(2).

Vitamin E, found abundantly in sweet potato also exhibited anti human papillomavirus and herpes infections effect through decreased viral load and increased antiviral cytokine and peroxynitrite plasma levels(3).

According to the, vitamin E in the form of d, alpha-tocopherol acetate, in dose of 400 IU, 4 times a day, may be a highly effective therapy for patients with herpes zoster or zona(4).

Vitamin A, a bi-polar molecule formed by bonds between carbon and hydrogen and fat soluble vitamin, found abundantly in tomato is associated to patient with herpes zoster infections. Accoridng to the Wake Forest University School of Medicine, acute reductions in concentrations of plasma retinol (vitamin A) in patient with shingle may be related to existence of herpes zoster infection in recipients(5).

Taking altogether, The combination of Orange, Sweet Potato and Tomato may offer the potential effect not only in prevention of the onset and treatment of Chicken Pox caused by Varicella-zoster virus.
Children with increased risk of Chicken Pox are wise to drink at least one serving daily. Children with Chicken Pox should drink the juice as much as they can, depending to the toleration of digestive system.

All Forms of Arthritis are Curable
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By addressing the Underlying Causes through Clinical Trials and Studies

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Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

References

(*) Reye’s Syndrome (national Reye’s Syndrome association)
References
(1) Intravenous vitamin C in the treatment of shingles: results of a multicenter prospective cohort study. by Schencking M1, Vollbracht C, Weiss G, Lebert J, Biller A, Goyvaerts B, Kraft K.(PubMed)
(2) Cantharidin patches and intravenous administration of vitamin C in the concomitant treatment of herpes zoster: a case report by Schencking M1, Kraft K.(PubMed)
(3) Coenzyme Q(10), vitamin E, selenium, and methionine in the treatment of chronic recurrent viral mucocutaneous infections by De Luca C1, Kharaeva Z, Raskovic D, Pastore P, Luci A, Korkina L.(PubMed)
(4) Other treatments for herpes zoster neuralgia(PMC)
(5) Low plasma concentrations of retinol and alpha-tocopherol in hematopoietic stem cell transplant recipients: the effect of mucositis and the risk of infection by High KP1, Legault C, Sinclair JA, Cruz J, Hill K, Hurd DD.(PubMed)

Most common Diseases of 50plus: The Obesity' Research and Studies of Green tea on weight maintenance

You can calculate your BMI index BMI= weight (kg)/ height (m2)

The Research and Studies of Green tea on weight maintenance

In the investigation of whether green tea may improve weight maintenance by preventing or limiting weight regain after weight loss of 5 to 10 % in overweight and moderately obese subjects. A randomised, parallel, placebo-controlled design, conducted by Maastricht University (1). A total of 104 overweight and moderately obese male and female subjects (age 18-60 years; BMI 25-35 kg/m(2)) participated. The study consisted of a very-low-energy diet intervention (VLED; 2.1 MJ/d) of 4 weeks followed by a weight-maintenance period of 13 weeks in which the subjects received green tea or placebo. The result showed that in the green tea treatment, habitual high caffeine consumption was associated with a higher weight regain compared with habitual low caffeine consumption (39 (sd 17) and 16 (sd 11) %, respectively; P<0.05).

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

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(1) "Effects of green tea on weight maintenance after body-weight loss" by Kovacs EM, Lejeune MP, Nijs I, Westerterp-Plantenga MS., posted in PubMed

Most common Diseases of 50plus: Heart Disease(The Articles) - Heart diseases Affecting Heart Valves

Heart Disease

Beside cancer, heart disease kills more than 2,000 Americans everyday. Approximately 60 million Americans have heart disease. There are many causes of heart disease. Anything that serves to damage the inner lining of blood vessels and impedes the transportation of oxygen and nutrition to the heart can be defined as a risk of heart disease.

Heart diseases Affecting Heart Valves

Heart diseases are caused by high blood pressure that contributes to the hardening of the arteries. High levels of bad cholesterol (LDL) build up in the arteries as a result of uncontrolled diet with high levels of saturated fat and trans fat.

Heart diseases affecting heart valves occur when the mitral valve in the heart narrows, causing the heart to work harder to pump blood from the left atrium into the ventricle.

1. Mitral Stenosis
Mitral Stenosis is a heart valve disorder that involves a narrowing or blockage of the opening of the mitral valve causing the volume and pressure of blood in the left atrium increases.

2. Mitral valves regurgitation
Mitral regurgitation is the heart disease in which your heart's mitral valve doesn't close tightly causing the blood to be unable to move through the heart efficiently. Symptoms of mitral valve regurgitation are fatigue and shortness of breath.

3. Mitral valves prolapse
In mitral valve prolapse, one or both leaflets of the valve are too large resulting in uneven closure of the valve during each heartbeat. Symptoms of mitral valves prolapse are palpitation, shortness of breath, dizzy, fatigue and chest pains.

4. Aortic Stenosis
With aging, protein collagen of the valve leaflets are destroyed and calcium is deposited on the leaflets causing scarring, thickening, and stenosis of the valve therefore increasing the wear and tear on the valve leaflets resulting in the symptoms and heart problems of aortic stenosis.

5. Aortic regurgitation
Aortic regurgitation is the leaking of the aortic valve of the heart that causes blood to flow in the reverse direction during ventricular diastole, from the aorta into the left ventricle. Symptoms of aortic regurgitation include fatigue or weakness, shortness of breath, chest pain, palpitation and irregular heart beats.

6. Tricuspid stenosis
Tricuspid stenosis is the narrowing of the orifice of the tricuspid valve of the heart causing increased resistance to blood flow through the valve. Symptoms of tricuspid stenosis include fatigue, enlarged liver, abdominal swelling, neck discomfort and leg and ankle swelling.

7. Tricuspid regurgitation.
Tricuspid regurgitation is the failure of the right ventricular causing blood to leak back through the tricuspid valve from the right ventricle into the right atrium of the heart. Symptoms of tricuspid regurgitation include leg and ankle swelling and swelling in the abdomen.

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

Anti Ageing Tips: Clinical proven in Reduced Visibility of Forehead Fine Lines up to 100%

The α-tocopherol form of vitamin E
The equipment and Preparation
1. One bottle of synthetic vitamin C 100x 500mg tablets. You can purchase this in any pharmacy for about $5.00
2. A bottle of vitamin E purified oil (You can only buy it from any pharmacy for $10) (We used provitamin E produced by Jamieson, due to complaints of irritation and stickiness of many tested subjects, You can also buy it at any pharmacy and super market for about $20 for a jar of 60ml)
2. A small bottle carries 100mL of warm tap water or still-water if desire.
3. A roll of bounty or a half hand size sponge.
4. A pair of plastic glove.

Please Note, Kyle J. Norton and Associates DO NOT receive funding for Jamieson(The giant vitamins company)

How to make Dehydroascorbic acid (DHA) 4% concentration
Day one
Put 8 tablets of synthetic vitamin C into the bottle which carries 100 mL of water[(8x500mg)/100mL=4000mg/100,000mg=4/100=4% concentration ofDehydroascorbic acid (DHA)] on the day before application to make sure all vitamin C tablets are dissolved.

How to reduced visibility of forehead fine lines up to 100%
Fine line is a result of effect of gravity in aging, and causes of slower process in cell rejuvenation and longer in elastic fibers replacement. Some researchers insisted that adding to the aging skin, free radicals and inflammatory molecules may degrade facial skin even quicker.
The next day
Put on your glove. Shake the bottle well. Pour some Dehydroascorbic acid (DHA ) onto a piece of fold-twice bounty paper towels.
Apply the solutions 3 times a days
Application first of Dehydroascorbic acid (DHA) 4% concentration to induce forehead fine line skin cleansing through its detoxified, antioxidant and cell regeneration effects by rubbing against the skin of the effects area with little pressure for about one minutes. Apply more solution if require. Wait for 5 minutes then apply vitamin E directly and generously onto the fine lines for enhancement of cell regeneration and elastic fibers replacement effects.

After applying, clean the sponge if used and glove, return and store the bottle of solution and vitamin E into first aid box in room temperature. Replace the solution of Dehydroascorbic acid (DHA ) every ten days to retain accurate concentration.

What to expect
1. In the first few days of application
Visibility of forehead fine lines shows signs of receding

2. In a few weeks
Depending to types of skin and severity of the effected areas, and according to our clinical study
Up to 100% of forehead fine lines have been removed depending to age, types of skin and severity of the effect areas, according to the study of ages between 57 - 62(Approximately, 5% and 60% of tested-subjects had achieved reduced visibility of 100% and 80% of forehead fine lines after 12 weeks, respectively).

Millions have been spent in our studies, we provide this information free and do not ask for anything in return. You promise to tell everyone you know about this webpage and retweet it, so they do not waste any more money on ineffective commercial products.

Precautions
1. Always testing your topical skin solution, including Dehydroascorbic acid (DHA ) and vitamin E for allergic reaction, by applying a tiny portion onto your wrist for 5 minutes. Do not use the solution if there is.
2. Although there were no adverse effect in our study, please make sure you always wear gloves before applying, as higher concentration than that ofDehydroascorbic acid (DHA) 4% concentration has been shown to cause brownness on the finger nails.
3. The Dehydroascorbic acid (DHA) 4% concentration has been shown to cause yellowness on the surface of some metal (very old) sinks, please make sure your test it to avoid the same messes.
4. Higher concentration of the solution has been used in skin tanning industry, please make that Dehydroascorbic acid (DHA) 4% concentration is completely absorbed(about 5- 10 minutes) into your skin before going to the extreme sun.
5. If the solutions get into your eyes, use tap water to clear them.
6. Do not attempt to make higher than Dehydroascorbic acid (DHA) 4% concentration solution, as it has not been tested.

All articles written by Kyle J. Norton are for information & education only, please consult your Doctor & Related field specialist before applying. If you have any questions about this article, please email at Kylenorton@live.ca

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

References
(a) http://kylejnorton.blogspot.ca/2014/06/dehydroascorbic-acid-dhavitamin-c.html
(b) http://kylejnorton.blogspot.ca/2014/04/skin-aging-in-vitamin-e-points-of-view.html
(c) http://kylejnorton.blogspot.ca/2014/08/vitamin-dehydroascorbic-acid-dha-and.html
(1) http://kylejnorton.blogspot.ca/2014/10/anti-skin-aging-in-dehydroascorbic-acid.html
(2) http://kylejnorton.blogspot.ca/2014/04/skin-aging-in-vitamin-points-of-view.html
(3) http://kylejnorton.blogspot.ca/2014/04/skin-aging-in-vitamin-e-points-of-view.html

Traditional Chinese Medicine Herbal Therapy - Popular Herbal Chinese Herbs – Bai Jiang Can (Bombyx Batryticatus)

2. Localized neurodermatitis (Skin diseases)
Jiang can (Bai Jiang Can, Bombyx Batryticatus) in modified yangxue dingfeng tang (a decoction for nourishing the blood and expelling wind), has exhibited a better and stable effect for the localized neurodermatitis, according to the study of “Treatment of the localized neurodermatitis by plum-blossom needle tapping and with the modified yangxue dingfeng tang–a clinical observation of 47 cases” by Weiying L, Yuanjiang D, Baolian L(2).

3. Lipid peroxidation and protection of antioxidative enzymes.
Bombycis corpus(BC), a is a drug consisting of the dried larva of silkworm has denomstrated the effect against Abeta -induced cytotoxicity in cultured astrocyte cells through the inhibition of lipid peroxidation and protection of antioxidative enzymes, according to the study of “Bombycis corpus extract prevents amyloid-beta-induced cytotoxicity and protects superoxide dismutase activity in cultured rat astrocytes” Kim HJ, Lee WH, Yoon CH, Jeong JC, Nam KS, Kim HM, Choo YK, Lee MC, Kim CH.(3).

4. Ovarian cancer
Bai Jiang Can contains high amount of Asparagine, a chemical compound may be considered for next steps in the development of ASNS as a biomarker for ovarian cancer treatment, according to the study of “Asparagine synthetase: a new potential biomarker in ovarian cancer” by Lorenzi PL, Weinstein JN(4).

5. Anti bacterial and fungal activity
Beauvericin shows the potential use of the endophytic fungus for its biological role in providing its host plant with protection, as well as the possible development of beauvericin as an antibacterial, according to the study of “Beauvericin from the endophytic fungus, Fusarium redolens, isolated from Dioscorea zingiberensis and its antibacterial activity” byXu L, Wang J, Zhao J, Li P, Shan T, Wang J, Li X, Zhou L.(5).

6. Impotent
Dimethyladenosine may be a lead compound of Bai Jiang Can for the development and improvement of vasculogenic impotence drugs through phosphodiesterase inhibition and NO production in endothelial cells., according to the study of “Purification of a dimethyladenosine compound from silkworm pupae as a vasorelaxation substance” by Ahn MY, Shim SH, Jeong HK, Ryu KS.(6).

Side Effects
1. Do not take if you suffer from high blood pressure (not controlled) or have a heart condition(a)
2. Do not take the herb if you are pregnant or breast feeding with out approval of related field specialist.
3. Etc.
Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/12784912
(2) http://www.ncbi.nlm.nih.gov/pubmed/17078443
(3) http://www.ncbi.nlm.nih.gov/pubmed/11207060
(4) http://www.ncbi.nlm.nih.gov/pubmed/19209300
(5) http://www.ncbi.nlm.nih.gov/pubmed/20521553
(6) http://www.ncbi.nlm.nih.gov/pubmed?term=Bombyx%20mori%20L%20and%20impotence%20
(a) http://www.lewtress-health.com/subprod/bombyx-mori-male-aphrodisiac-0003451.aspx

Most common Diseases Free and Longevity of 50 plus - Organic Soy(Whole Food) Part C By Phytochemicals in Foods - Genistein

Over the years of research, 4 foods appeared mostly in medical studies in preventing and treating diseases, are Green Tea, Grape seed and skin, Turmeric and Organic Soy(Not for Western Women). All Right Reserved.

IV. Organic Soy
Soy foods, including tofu have been in traditional Chinese diet over thousands of year, according to Chinese literature. The reduced risk of chronic disease in Asian population, including metabolic syndrome such as cardiovascular diseases, obesity and diabetes and lesser menopause symptoms in advanced age, may be aided by eating a lot of soy food accompanied with large portion of vegetables and fruits. Indeed, according to the study, only 10% of women in the East are experience symptoms of menopause in advanced age compared to over 70% of their Western counterparts.
According to Dr. Mark Messina, Ph.D., Soy foods contributed from 6.5%8 to 12.8%7 of total protein intake in older adult in Japan.(b)

The approval of cardiovascular benefit of soy by FDA in 1999 accompanied with the discovery of health benefits in clinical studies over past decade, prompted the promotion and advertisement of soy's health benefits in every aspect in Western society. Evidences could be seen by walking through the supermarkets and drug stores. Soy supplements and products such as tofu, soy milk, soy-based infant formula, and meatless “texturized vegetable protein” burgers were widely available. According to the United Soybean Board’s 2004–2005, 25% of Americans consumed soy foods or beverages at least once per week, and 74% viewed soy products as healthy.

Today, the promotion of soy is no longer existed, it may be results of discovery of adverse effects in single ingredient and animal studies, as intake of soy is associated to induce risk of certain mammary cancers and infertility. The publication of the result have drawn many criticisms. According to Thomas Badger, director and senior investigator at the Arkansas Children’s Nutrition Center in Little Rock, these effects are seen only under certain experimental conditions that are not likely to occur in humans—and therein lies the crux of the debate(a).Equol (4',7-isoflavandiol), an isoflavandiol metabolized from daidzein may be the causes, as 90% of Eastern population are equol producers but only 30% in the West.
The explanation of the positive effect of soy isoflavones in reduced risk of mammary cancers by University of Goettingen may be interesting, as researchers said" Most importantly, there is dispute as to whether isoflavones derived from soyor red clover have negative, positive or any effect at all on the mammary gland or endometrium. It is beyond any doubt that soy products may have cancerpreventing properties in a variety of organs including the mammary gland. However, these properties may only be exerted if the developing organ was under the influence of isoflavones during childhood and puberty".

Soybean is genus Glycine, the family Fabaceae, one of the legumes that contains twice as much protein per acre as any other major vegetable or grain crop, native to Southeast Asia. Now, it is grown worldwide with suitable climate for commercial profit and a a healthy foods.

Nutrients
1. Carbohydrates
2. Dietary fiber
3. Fat
4. Protein
5. Essential amino acid
6. Vitamin A
7. Vitamin B6
8. Vitamin B12
9. Vitamin C
10. Vitamin K
11. Calcium
12. Iron
13. Magnesium
14. Phosphorus
15. Potassium
16. Sodium
17. Zinc
18. Etc.
Phytochemicals
1. Isoflavones
2. Genistein
3. Saponins
4. Beta-sitosterol
5. Daidzein

D. By Phytochemicals in Foods - Genistein

Genistein is a phytochemical in the Isoflavones, belonging to the group of Flavonoids (polyphenols), found abundantly in food of the family of legumes, soy, alfalfa sprouts, red clover, chickpeas, peanuts, etc.
1. Bladder Cancer
In a phase 2 randomized, placebo-controlled trial investigated whether daily, oralgenistein (300 or 600 mg/day as the purified soy extract G-2535) for 14-21 days before surgery alters molecular pathways in bladder epithelial tissue in 59 subjects diagnosed with urothelial bladder cancer (median age 71), found that G-2535 treatment was well tolerated; observed toxicities were primarily mild to moderate gastrointestinal or metabolic and usually not attributed to study drug. Genisteinwas detected in plasma and urine of subjects receiving G-2535 at concentrations greater than placebo subjects' but were not dose-dependent. Reduction in bladder cancer tissue p-EGFR staining between the placebo arm and the combinedgenistein arms was significant at the protocol-specified significance level of 0.10 (p=0.07), according to "A Phase 2 Cancer Chemoprevention Biomarker Trial of Isoflavone G-2535 (Genistein) in Presurgical Bladder Cancer Patients" byMessing E, Gee JR, Saltzstein DR, Kim K, Disant'agnese PA, Kolesar J, Harris L, Faerber A, Havighurst TC, Young JM, Efros M, Getzenberg RH, Wheeler MA, Tangrea J, Parnes HL, House M, Busby JE, Hohl RJ, Bailey HH.(1)

2. Immunomodulation And Anti-Inflammation
In the review of new concepts have emerged in relation to mechanisms that contribute to the regulation of carcinogenesis processes and associated inflammatory effects, found that the effects of polyphenols on the adaptative and innate immune cells that could infiltrate the tumor. Reduction of chronic inflammation or its downstream consequences may represent a key mechanism in the fight of cancer development and polyphenols could reduce various pro-inflammatory substance productions through targeting signal transduction or through antioxidant effects, according to "Immunomodulation And Anti-Inflammatory Roles Of Polyphenols As Anticancer Agents" by Ghiringhelli F, Rébé C, Hichami A, Delmas D.(2)

3. Bone density
In the investigation of the association between habitual phyto-oestrogen intake and broadband ultrasound attenuation (BUA) of the calcanaeum as a marker of bone density, found that the non-soya isoflavones formononetin and biochanin A were marginally significant or significantly associated with BUA in postmenopausal women (β = 1·2; P < 0·1) and men (β = 1·2; P < 0·05), respectively; enterolignans and equol were positively associated with bone density in postmenopausal women, but this association became non-significant when dietary Ca was added to the model. In the lowest quintile of Ca intake, soya isoflavones were positively associated with bone density in postmenopausal women (β = 1·4; P < 0·1), according to "Association between dietary phyto-oestrogens and bone density in men and postmenopausal women" by Kuhnle GG, Ward HA, Vogiatzoglou A, Luben RN, Mulligan A, Wareham NJ, Forouhi NG, Khaw KT.(3)

4. Antioxidant effects
In the testing effects of the soy isoflavone genistein on antioxidant enzymes in DU145 prostate cancer cells, found that Genistein significantly decreased reactive oxygen species levels and induced the expression of the antioxidant enzymes manganese (Mn) superoxide dismutase (SOD) and catalase, which were associated with AMP-activated protein kinase (AMPK) and phosphatase and tensin homolog deleted from chromosome 10 (PTEN) pathways. The induced expression of catalase, MnSOD, and PTEN were attenuated by pretreatment with a pharmacological inhibitor for AMPK. Furthermore, PTEN is essential forgenistein activity, as shown by PTEN transfection in PTEN-deficient PC3 cells. Thus, genistein induces antioxidant enzymes through AMPK activation and increased PTEN expression. indicating the effects of genistein primarily depend on AMPK, according to "The antioxidant effects of genistein are associated with AMP-activated protein kinase activation and PTEN induction in prostate cancer cells" by Park CE, Yun H, Lee EB, Min BI, Bae H, Choe W, Kang I, Kim SS, Ha J.(4)

5. Anti cancers
In the determination of Genistein, the predominant isoflavones found in soy, has been shown to inhibit the carcinogenesis in animal models, indicated that there are growing body of experimental evidence that show the inhibition of human cancer cells by genistein through the modulation of genes that are related to the control of cell cycle and apoptosis. Moreover, it has been shown that genistein inhibits the activation of NF-kappa B and Akt signaling pathways, both of which are known to maintain a homeostatic balance between cell survival and apoptosis. Genistein is commonly known as phytoestrogen, which targets estrogen- and androgen-mediated signaling pathways in the processes of carcinogenesis, according to"Soy isoflavones and cancer prevention" by Sarkar FH, Li Y.(5)

6. Prostate cells
In the investigation of the hypothesis that the soy-isoflavone genistein could protect DNA of LAPC-4 prostate cells from oxidative stress-related damage by enhancing the expression of antioxidative genes and proteins, found that genisteinprotects prostate cells from oxidative stress-related DNA damage presumably by inducing the expression of antioxidative products, such as metallothioneins.Genistein, therefore, might counteract the age-related decline of important antioxidative defence systems which in turn maintain DNA integrity, according to "Genistein protects prostate cells against hydrogen peroxide-induced DNA damage and induces expression of genes involved in the defence against oxidative stress" by Raschke M, Rowland IR, Magee PJ, Pool-Zobel BL(6)

7. Breast cancer
In the investigation of the potential preventive effects of lycopene and genistein, alone and in combination, on breast cancer development in female Wistar rats treated with 7,12-dimethylbenz[a]anthracene (DMBA), a carcinogen known to induce breast tumors.
found that treatment was continued for 20 wk. Rats treated with DMBA developed mammary tumors with 100% tumor incidence during the 20-wk study. Inhibition of mammary cancer incidence by lycopene (70%), genistein (60%) and their combination (40%) was observed. Tumor weight decreased by 48%, 61%, and 67%, and mean tumor volume decreased by 18%, 35%, and 65% with lycopene,genistein, and lycopene + genistein, respectively (P < 0.01 for the combination). The proportions of adenocarcinoma masses decreased with lycopene andgenistein combination (P < 0.05). Administration of lycopene and genisteincombination suppressed breast cancer development and was associated with a decrease in MDA, 8-isoprostane, and 8-OhdG levels and with an increase in serum lycopene and genistein levels. Animals administered DMBA developed breast cancer, which was associated with increased expression of Bcl-2 and decreased expression of Bax, caspase 3, and caspase 9 in mammary tissues, according to "Inhibitory effects of combination of lycopene and genistein on 7,12- dimethyl benz(a)anthracene-induced breast cancer in rats" by Sahin K, Tuzcu M, Sahin N, Akdemir F, Ozercan I, Bayraktar S, Kucuk O.(7)

8. Neuroprotective effects
in the investigation of whether GEN could alleviate oxidative damage induced by beta-amyloid peptides 25-35 (Abeta25-35) in PC12 cells, found that GEN attenuated the cytotoxicity and partially prevented apoptosis induced by Abeta25-35. GEN dramatically attenuated ROS levels induced by Abeta25-35 in PC12 cells. In addition, GEN significantly reversed the reduction of MMP caused by Abeta25-35 to maintain the normal levels of the cells. The GSH/GSSG ratio in GEN pretreated groups significantly increased compared to the groups without GEN pretreatment. GEN reversed Abeta25-35 induced down regulation of the protein expression of gamma-GCS, Nrf2 and HO-1, according to "Genistein as a neuroprotective antioxidant attenuates redox imbalance induced by beta-amyloid peptides 25-35 in PC12 cells" by Ma W, Yuan L, Yu H, Ding B, Xi Y, Feng J, Xiao R.(8)

9. Anti diabetes
In the investigation of the effect of genistein on beta-cell proliferation and cellular signaling related to this effect and further determined its antidiabetic potential in insulin-deficient diabetic mice, found that genistein induced protein expression of cyclin D1, a major cell-cycle regulator essential for beta-cell growth. Dietary intake of genistein significantly improved hyperglycemia, glucose tolerance, and blood insulin levels in streptozotocin-induced diabetic mice, concomitant with improved islet beta-cell proliferation, survival, and mass. These results demonstrate thatgenistein may be a natural antidiabetic agent by directly modulating pancreatic beta-cell function via activation of the cAMP/PKA-dependent ERK1/2 signaling pathway, according to "Genistein induces pancreatic beta-cell proliferation through activation of multiple signaling pathways and prevents insulin-deficient diabetes in mice" by Fu Z, Zhang W, Zhen W, Lum H, Nadler J, Bassaganya-Riera J, Jia Z, Wang Y, Misra H, Liu D.(9)

10. Bone homeostasis
In the deiermination of the effect of genistein on bone homeostasis in mandibular subchondral bone of rats.Methods:Female SD rats were administered withgenistein (10 and 50 mg/kg) or placebo by oral gavage for 6 weeks, found that the low and high doses of genistein significantly increased the expression of ERβ, while ERα expression was increased by the low dose genistein and decreased by the high dose genistein. ERβ silencing abrogated most of the effects of genisteintreatment.Conclusion:In rat mandibular condylar subchondral bone, low-dosegenistein increases bone formation and inhibit bone resorption, while excessgenistein inhibits both bone formation and resorption, according to"Dose-dependent effects of genistein on bone homeostasis in rats' mandibular subchondral bone" by
Li YQ, Xing XH, Wang H, Weng XL, Yu SB, Dong GY.(10)

11. Obesity
In the study of the role of ER alpha and ER beta in a model of nutrition induced obesity, found that Treatment with E2 and Alpha decreased body weight, total cholesterol and VLDL. Visceral fat mass, adipocyte size, and serum leptin were reduced by E2, Alpha and Beta. In the soleus muscle, treatment with E2 and Beta modulated Igf1 and Pax7 gene expression and resulted in larger muscle fibers, according to "Impact of estradiol, ER subtype specific agonists and genisteinon energy homeostasis in a rat model of nutrition induced obesity" by
Weigt C, Hertrampf T, Zoth N, Fritzemeier KH, Diel P.(11)

Etc.

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/22293631
(2) http://centaur.reading.ac.uk/20335/
(3) http://www.ncbi.nlm.nih.gov/pubmed/22292769
(4) http://www.ncbi.nlm.nih.gov/pubmed/20673057
(5) http://www.ncbi.nlm.nih.gov/pubmed/21736835
(6) http://www.ncbi.nlm.nih.gov/pubmed/14628433
(7) http://www.ncbi.nlm.nih.gov/pubmed/21958026
(8) http://www.ncbi.nlm.nih.gov/pubmed/20362658
(9) http://www.ncbi.nlm.nih.gov/pubmed/20484465
(10) http://www.ncbi.nlm.nih.gov/pubmed/22120966
(11) http://www.ncbi.nlm.nih.gov/pubmed/22230815