Medical Advisor Journals

Saturday, June 4, 2016

Most common Diseases of 50plus: The Obesity' Article of Serum Potassium and nonalcoholic fatty liver disease

The Obesity' Article of Serum Potassium and nonalcoholic fatty liver disease

Dietary Minerals are the group of minerals essential for our body to sustain normal functions and physical health.
In General, potassium is a very essential mineral to the human body for maintaining to build proteins and muscle, break down carbohydrates, maintain normal body growth and normal heart electricity, etc.
Fatty liver disease.
Fatty liver disease is defined as a condition of accumulation of fat in the liver, including people who drink little or no alcohol (Non alcohol fatty disease) or who are excessive alcohol drinking (Alcohol fatty liver disease). The disease can even occur after a short period of heavy drinking (acute alcoholic liver disease). More than 15 million people in the U.S. either abuse or overuse alcohol with fatty liver diseases with fat makes up 5-10 percent of liver weight.
Non-alcoholic fatty liver disease (NAFLD) encompasses a wide spectrum of clinical conditions, actually representing an emerging disease of great clinical interest(4).

The benefits
Nonalcoholic fatty liver disease (NAFLD) are associated to increased risk of metabolic syndrome. In the study of in 8592 subjects with NAFLD (30·3%) and gradually decreased across serum potassium quartiles, to investigate the association of serum potassium with the risk of prevalent NAFLD. The result showed a significant relation between serum potassium level and NAFLD in women, younger subjects, those with insulin resistance and central obesity. Other in the study to investigate the association between NAFLD and primary aldosteronism (PA), and to identify determinants of NAFLD in this condition, showed that Serum potassium was lower in primary aldosteronism (PA) than in LREH patients with NAFLD (P < 0.001), while it was similar in PA and LREH patients without NAFLD.

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

References
(1) Low serum potassium level is associated with nonalcoholic fatty liver diseaseand its related metabolic disorders by Sun K, Lu J, Jiang Y, Xu M, Xu Y, Zhang J, Xu B, Sun J, Sun W, Ren C, Liu J, Wang W, Bi Y, Ning G.(PubMed)
(2) Nonalcoholic fatty liver disease in primary aldosteronism: a pilot study by Fallo F, Dalla Pozza A, Tecchio M, Tona F, Sonino N, Ermani M, Catena C, Bertello C, Mulatero P, Sabato N, Fabris B, Sechi LA.(PubMed)
(3) Review article: the diagnosis of non-alcoholic fatty liver disease -- availability and accuracy of non-invasive methods by Festi D, Schiumerini R, Marzi L, Di Biase AR, Mandolesi D, Montrone L, Scaioli E, Bonato G, Marchesini-Reggiani G, Colecchia A.(PubMed)

Anti Ageing Tips: Clinical proven in getting rid of Acnes & Acne Scars and re smooth Your facial skin

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Who doesn't want to look 5, 10,15 or 20 years younger in comparison to people with the same age group?

The dream of finding the ingredients in rejuvenated aging skin has been ongoing since human civilization. Unfortunately, many ingredients with no commercial values have been discarded due to their effects in dampening the profits of cosmetic companies.

Don't ask me about commercial anti-aging products. Most of them are produced for making profits and do not perform as theirs' claims. Truly, if one is found to be effective, it will constitute to shelf-removal of many others with the same intention. Unfortunately, walking through the cosmetic section of health stores and super markets, thousands of these products are still packed on the shelves. How effective they are? You know the answer.

Most people know acne is caused by dirt in oily skin pores, but little is known that acne is also caused by the system of toxins in the body. If our liver and kidney can not cleanse all toxins in the body, then our skin become the third source for cleansing the remainder of toxins.

The below tips have been proven through our clinical studies of over 400 subjects between age of 57 - 63. If you are in this age, you can expect the same results(a)(b)(c).

Tip Five
How to get rid of Liver or Aging spots and re smooth Your facial skin

According to Dr. GEORGE E. MORRIS, M.D., in a study of 60 patients with acne being given 8 oz of citrus juice twice daily and vitamin C, (de oxidized form) of in 3 gm a day, after 4 months 43 showed improvement, 10 failed to show improvement and 7 did not return for follow up(1). Some articles showed that vitamin C may be effective in the reduction of the formation of acne scars through it’s anti-inflammatory and free radical scavenger activities(1), but no study of Dehydroascorbic acid (DHA ) in reduced formation of Acnes & Acne Scars has been found through searching on PubMed.

The Ingredients
A. Dehydroascorbic acid (DHA)(1)
1. The chemical reaction
Vitamin C + Water -----> Dehydroascorbic acid (DHA ) + 2e- +2H+
Chemical Structure

The equipment and Preparation
1. One bottle of synthetic vitamin C 100x 500mg tablets. You can purchase this in any pharmacy for about $5.00
2. A small bottle carries 100mL of warm tap water or still-water if desire.
3. A roll of bounty or a half hand size sponge.
4. A pair of plastic glove.

How to make Dehydroascorbic acid (DHA) 4% concentration
Day one
Put 8 tablets of synthetic vitamin C into the bottle which carries 100 mL of water[(8x500mg)/100mL=4000mg/100,000mg=4/100=4% concentration ofDehydroascorbic acid (DHA)] on the day before application to make sure all vitamin C tablets are dissolved.

How to remove Acnes & Acne Scars and re smooth Your facial skin
The next day
Put on your glove. Shake the bottle well. Pour some Dehydroascorbic acid (DHA ) onto a piece of fold-twice bounty paper towels. Apply the solution 3 times a days by rubbing against the skin of the effects area with little pressure for about one minutes. Apply more solution if require. Dehydroascorbic acid (DHA) 4% concentration should be able to get rid of the appearance of some acnes, prevent the re-occurrence, recover past acne scar through cell rejuvenation, and re smooth some of the skin on the effect areas in a few days.

After applying, clean the sponge if used and glove, return and store the bottle of solution into first aid box in room temperature. Replace the solution every ten days to retain accurate concentration.

What to expect
How Dehydroascorbic acid (DHA) exhibited its detoxified, antioxidant, anti inflammatory and enhanced cell regeneration effects in getting rid of Acnes & Acne Scars and re smooth Your facial skin.
1. In the first few days of application
a. Reduced inflammation cause of Acnes on the skin to recede,
b. Prevent the occurrence of new acnes
b. Some of the effected skin area start to smooth out
c. Enhanced cell rejuvenation, Small size acne scars begin to recover

2. In a few weeks
Depending to types of skin and severity of the effected areas, and according to our clinical study
a. Up to 100% of removal of all acne (90% of test subjects achieved this result) and No re occurrence of acnes over 12 weeks of study depending to age, types of skin and severity of the effect areas, according to the study of ages between 57 - 62.
b. Recovered most mall size of acne scars (90% of test subjects achieved this result), continued recovery of large size acne scars and marks of recovered small acne scars are still visible on all tested subjects, at the 12 weeks study.
c. Smooth up to 100% of the effect areas depending to age, types of skin and severity of the effect areas, according to the study of ages between 57 - 62[approximately, 70 % (100% of moderate and 80% of severe tested-subjects) had achieved that result].
As the results, we suggested that the effectiveness of Dehydroascorbic acid (DHA) 4% concentration in getting rid of f Acnes & Acne Scars and re smooth Your facial skin may be through its detoxified, free radical scavenging, anti inflammatory and enhanced cell regeneration activities.

Millions have been spent in our studies, we provide you this information free and do not ask for anything in return. You promise to tell everyone you know about this webpage and retweet it, so they do not waste their money on ineffective commercial products.

Precautions
1. Always testing your topical skin solution, including Dehydroascorbic acid (DHA ) for allergic reaction, by applying a tiny portion onto your wrist for 5 minutes. Do not use the solution if there is allergic reaction.
2. Although there were no adverse effect in our study, please make sure you always wear gloves before applying, as higher concentration of the solution has shown to brownness on the finger nails.
3. The solution has shown to cause yellowness on the surface of some metal (very old) sinks, please make sure your test it to avoid the same messes.
4. Higher concentration of the solution has been used in skin tanning industry, please make the solution is completely absorbed(about 5- 10 minutes) into your skin before going to the extreme sun.
5. If the solution get into your eyes, use tap water to clear them.
6. Do not attempt to make higher solution and put them on your facial skin, as it has not been tested.
If you have any questions, please email me at kylenorton@live.ca

All articles written by Kyle J. Norton are for information & education only, please consult your Doctor & Related field specialist before applying

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
References
(a) http://kylejnorton.blogspot.ca/2014/06/dehydroascorbic-acid-dhavitamin-c.html
(b) http://kylejnorton.blogspot.ca/2014/04/skin-aging-in-vitamin-e-points-of-view.html
(c) http://kylejnorton.blogspot.ca/2014/08/vitamin-dehydroascorbic-acid-dha-and.html
(1) http://kylejnorton.blogspot.ca/2014/10/anti-skin-aging-in-dehydroascorbic-acid.html
(2) http://kylejnorton.blogspot.ca/2014/04/skin-aging-in-vitamin-points-of-view.html
(3) http://kylejnorton.blogspot.ca/2014/04/skin-aging-in-vitamin-e-points-of-view.html

Most Common Disease of 50plus: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Polymyalagia Arthritis (Rheumatica) Treatment: Non Medication and Diet therapy

Musculoskeletal disorders (MSDs) are medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed(1).

Types of Musculo-Skeletal disorders in elder(2)
1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalgia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia

Polymyalgia Arthritis (Rheumatica)

Polymalgia Arthritis is defined as a condition a common inflammatory rheumatic disease which causes pain, stiffness and tenderness in large muscles, including muscles shoulders and pelvic girdle as a result of the presence of a synovitis in proximal joints and periarticular structures.

Treatments
A. In conventional medicine perspective
A.1. Non Medication
1. Fasting as part of a naturopathic treatment
Fasting may be formed part of polymyalgia rheumatica (PMR) treatment, according to the Dr. Stange R. and Dr, Pflugbeil C. a complex therapy with methods of natural medicine comprising fasting as its main treatment element may be the best solution for treatment of the diseases(148), as the therapy has significant improvement of the immune condition of the intestine and consequently of the whole body(149).

2. Diet therapy
Leucine-rich milk and whey proteins may be a potential treatment of age related loss of muscle mass and strength, according to the study of Douglas Paddon-Jones and Dr. Blake B. Rasmussen(150). Other in a A randomized double blind crossover trial, suggested that exercise and amino acid supplementation (AAS) together may be effective in enhancing not only muscle strength, but also combined variables of muscle mass and walking speed and of muscle mass and strength in sarcopenic women(151).

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

References

(148) [Fasting as part of a naturopathic treatment approach for polymyalgia rheumatica].[Article in German] by Stange R1, Pflugbeil C.(PubMed)
(149)[Progression of intestinal secretory immunoglobulin A and the condition of the patients during naturopathic therapy and fasting therapy].[Article in German] by Beer AM1, Rüffer A, Balles J, Ostermann T.(PubMed)
(150) Dietary protein recommendations and the prevention of sarcopenia Protein, amino acid metabolism and therapy by Douglas Paddon-Jones and Blake B. Rasmussen(PubMed)
(151) Similar effects of leucine rich and regular dairy products on muscle mass and functions of older polymyalgia rheumatica patients: a randomized crossover trial. by Björkman MP1, Pilvi TK, Kekkonen RA, Korpela R, Tilvis RS.(PubMed)

Food therapy - Vegetables - Brussels Sprouts (Brassica oleracea)

Brussels sprout is a species of wild cabbage (Brassica oleracea), belong to the family of Brassicaceae and was cultivated since ancient Rome.

Nutritients
1. Carbohydrates
2. Sugars
3. Fiber
4. Omega 3 Fatty acid
5. Protein
6. Vitamin A
7. Thiamine (Vitamin B1)
8. Riboflavin (Vitamin B2)
9. Niacin (Vitamin B3)
10. Pantothenic acid (Vitamin B5)
11. Folate (Vitamin B9)
12. Vitamin C
13. Vitamin E
14. Vitamin K
15. Calcium
16. Copper
17. Iron
18. Magnesium
19. Manganese
20. Phosphorus
21 Potassium
22. Sodium
23. Zinc
24. Etc.

Health Benefits
A. Health benefits according to studies
1. Detoxification
In the investigation of cruciferous vegetables, myrosinase metabolizes the relatively inactive glucosinolates into isothiocyanates and other products that have the ability to increase detoxification enzyme expression found that as predicted by the in vitro experiment, in vivo exposure to Brussels sprouts with active myrosinase resulted in greater induction of both phase I and phase II detoxification enzymes in the liver and the lungs that correlated with plasma sulforaphane concentrations, according to "Induction of detoxification enzymes by feeding unblanched Brussels sprouts containing active myrosinase to mice for 2 wk"by Robbins MG, Hauder J, Somoza V, Eshelman BD, Barnes DM, Hanlon PR.(a)

2. Antioxidants
In the evaluation of consumption of the sprouts and its antioxidant effects found that Serum vitamin C levels were increased by 37% after sprout consumption but no correlations were seen between prevention of DNA-damage and individual alterations of the vitamin levels. Our study shows for the first time that sprout consumption leads to inhibition of sulfotransferases in humans and to protection against PhIP and oxidative DNA-damage, according to "Consumption ofBrussels sprouts protects peripheral human lymphocytes against 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and oxidative DNA-damage: results of a controlled human intervention trial"by Hoelzl C, Glatt H, Meinl W, Sontag G, Haidinger G, Kundi M, Simic T, Chakraborty A, Bichler J, Ferk F, Angelis K, Nersesyan A, Knasmüller S.(b)

3. Thyroid function
In the observation of the effect of dietary Brussels sprouts, a particularly rich source of such glucosinolates, on thyroid function found that a normal diet of 10 volunteer subjects had no effect on thyroid function as determined by measurement of thyrotrophic hormone, thyroxine and tri-iodothyronine even though the sprouts contained high concentrations (220 mg/100 g) of glucosinolates. In view of the reported antithyroid activity of 5-vinyloxazolidine-2-thione it is suggested that this lack of activity of cooked Brussels sprouts is due to inactivation during cooking of myrosinase, the specific glucosinolate-degrading enzyme, according to "Preliminary observations on the effect of dietarybrussels sprouts on thyroid function" by McMillan M, Spinks EA, Fenwick GR.(c)

4. Anti Cancers
In the classification of the cancer-preventive effect of brassica vegetables, including cabbages, kale, broccoli, Brussels sprouts, and cauliflower, found that most evidence concerning anticarcinogenic effects of glucosinolate hydrolysis products and brassica vegetables has come from studies in animals. In addition, studies carried out in humans using high but still realistic human consumption levels of indoles and brassica vegetables have shown putative positive effects on health. The combination of epidemiological and experimental data provide suggestive evidence for a cancer preventive effect of a high intake of brassicavegetables, found that "Brassica vegetables and cancer prevention. Epidemiology and mechanisms" by van Poppel G, Verhoeven DT, Verhagen H, Goldbohm RA.(d)

5. Type 2 diabetes
In the determination of young broccoli sprouts improve oxidative stress status in diabetic condition found that 63 patients in three groups were included in the analysis: 10 g/d BSP (n=21), 5 g/d (n=22) and placebo (n=20). After 4 weeks, consumption of BSP resulted in significant decrease in malondialdehyde (MDA) (P=0.001 for treatment effect), oxidized low density lipoprotein cholesterol (P=0.03 for treatment effect), OSI (P=0.001 for treatment effect) and significant increase in Serum total antioxidant capacity (TAC) (P=0.001 for treatment effect), according to "Broccoli sprouts reduce oxidative stress in type 2 diabetes: a randomized double-blind clinical trial" by Bahadoran Z, Mirmiran P, Hosseinpanah F, Hedayati M, Hosseinpour-Niazi S, Azizi F.(e)

6. Etc.

B. Health benefits according to concentration
1. Vitamin K
Vitamin K not only plays an important role in protecting our skin from aging, it is also needed for the proper clotting of blood, thus decreasing the risk of excessive bleeding, in a study of "Delayed vitamin K deficiency as a cause of bleeding: still a concern in the 21st century!" by Kasatkar P, Shetty S, Ghosh K., posted inPubMed, researchers found that Laboratory tests confirmed acquired bleeding diathesis due to vitamin K deficiency, which was corrected after adequate vitamin K supplementation. VKDB is not an uncommon phenomenon and should be considered in the differential diagnosis of a child with bleeding diathesis.

2. Vitamin CIn the evaluation of pulmonary dysfunction. and it effects on pulmonary dysfunction found that At present, evidence from randomised-controlled trials is insufficient to recommend a specific role for vitamin C in the treatment ofasthma. Further methodologically strong and large-scale randomised controlled trials are needed in order to address the question of the effectiveness of vitamin Cin children with asthma but some outcome data showed effectiveness on lung function, symptom scores, IgE levels and inhaled steroid use. One small study showed a significant difference in % drop in FEV1 post-exercise, according to the study of "Vitamin C supplementation for asthma" by Kaur B, Rowe BH, Arnold E.(1)

3. ManganeseIt is one of important trace in preventing osteoporosis, according to the study of "[Study of estrogen deficiency impact on manganese levels in teeth and mandible of rats after ovariectomy]. [Article in Polish]" by Rahnama M, Błoniarz J, Zareba S, Swiatkowski W.(1)and regulating blood sugar level, according to the study of "[An inadequate intake of manganese may favour insulin resistance in girls]. [Article in Spanish]" by Rodríguez-Rodríguez E, Bermejo LM, López-Sobaler AM, Ortega RM.(2)

4. Dietary fiberDaily intake of right amount of fibers can prvent and treata. Diabetes, as Increased consumption of vegetables, whole grains, and soluble and insoluble fiber is associated with improved glucose metabolism in both diabetic and nondiabetic individuals. Improvements in insulin sensitivity and glucose homeostasis were more evident in participants following a plant-based diet compared with other commonly used diets, according to the study of "Efficacy of high-fiber diets in the management of type 2 diabetes mellitus" by Wolfram T, Ismail-Beigi F.(3)

5. FolateIn the investigation of the prevalence and multifactorial etiology of anemia among Indian human immunodeficiency virus (HIV)-infected children and its effect on anemia, found that Anemia, particularly iron deficiency anemia and anemia of inflammation, is highly prevalent among children with HIV infection. Micronutrient supplements (iron and, folate) combined with ART(antiretroviral therapy) improved anemia in HIV-infected children, according to "The prevalence and etiology of anemia among HIV-infected children in India" by Shet A, Arumugam K, Rajagopalan N, Dinakar C, Krishnamurthy S, Mehta S, Shet AS.(4)
6. Etc.

C. Other health benefits
1. Antioxidants
Since brussels sprouts contains phyto-nutrients and antioxidants such as vitamin A and C, it helps to improve the immune system in fighting against the forming of free radicals, thus decreasing the risk of irregular cell growth, including tumor and cancer, according to "Antioxidants - Cancers and Diseases - Section Antioxidants"(I)

2. Body cleansing and detoxification.
Brussels sprouts, contains high amounts of vitamin C which play a major role, acting as cofactors for many enzyme systems including those of liver detoxification, in cleansing the body toxins, according to "[Features of vitamin Cmetabolism and the functional status of the liver in alcoholism and alcoholic delirium in the stage of detoxification therapy].[Article in Russian]" Shugaleĭ IuS.(II)

3. Rheumatoid arthritis
Brussels sprout contains high amount of antioxidants that enhances the immune system fighting against inflammation thus reducing the risk of chronic inflammation of the joints, according to "Antioxidants and antiinflammatory dietary supplements for osteoarthritis and rheumatoid arthritis" by Rosenbaum CC, O'Mathúna DP, Chavez M, Shields K.(III)

4. Heart diseases
Brussels sprout contains high amount of fiber which helps to bind the bad cholesterol from forming plague attached to the arterial walls, thus reducing the risk of heart diseases, according to "Effects of soluble dietary fiber on low-density lipoprotein cholesterol and coronary heart disease risk" by Bazzano LA.(IV)

5. Folate (Vitamin B9)
Folate can help prevent serious the neural tube defect causes of neural tube fails to close completely during the early weeks of pregnancy, causing to severe physical disabilities and developmental delay, according to "Folate and neural tube defects" by Pitkin RM.(V)
6. Etc.

Side Effects
1. Allergic effect
2. Mild oxalates can cause health problem for people with untreated kidney and gallbladder diseases.
3. Overcooking causes the releases sulfurous odor, dislike by some people.
4. No other known side effect.

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

Sources
(a) http://www.ncbi.nlm.nih.gov/pubmed/20722931
(b) http://www.ncbi.nlm.nih.gov/pubmed/18293303
(c) http://www.ncbi.nlm.nih.gov/pubmed/2419242
(d) http://www.ncbi.nlm.nih.gov/pubmed/10736624
(e) http://www.ncbi.nlm.nih.gov/pubmed/21559038
(1) http://www.ncbi.nlm.nih.gov/pubmed/21285035
(2) http://onlinelibrary.wiley.com/doi/10.1111/j.1469-8749.2010.03724.x/pdf
(3) http://www.ncbi.nlm.nih.gov/pubmed/22072339
(4) http://www.ncbi.nlm.nih.gov/pubmed/20713332

(I) http://the-anti-aging-guide.blogspot.com/2011/03/anti-aging-guide.html
(II) http://www.ncbi.nlm.nih.gov/pubmed/3577514
(III) http://www.ncbi.nlm.nih.gov/pubmed/20232616
(IV) http://www.ncbi.nlm.nih.gov/pubmed/18937894
(V) http://www.ncbi.nlm.nih.gov/pubmed/17209211

Phytochemicals In Foods: The effects of Gamma-linolenic acid

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Gamma-linolenic acid

Gamma-linolenic acid is a phytochemincalsin the group of Omega-3, 6,9 fatty acids, belonging the class of Lipids, found abundantly in evening primrose, borage, blackcurrant, etc.

Health Benefits
1. Neuropathic symptoms
in the evaluation of the effects of alpha-lipoic acid (ALA) and gamma-linolenic acid(GLA) and the beneficial effect of physical exercise on positive sensory symptoms and neuropathic pain in patients with compressive radiculopathy syndrome from disc-nerve root conflict, found that oral treatment with alpha-lipoic acid (ALA) andgamma-linolenic acid (GLA) for six weeks in synergy with rehabilitation therapy improved neuropathic symptoms and deficits in patients with radicular neuropathy, according to "The use of alpha-lipoic acid (ALA), gamma linolenic acid (GLA) and rehabilitation in the treatment of back pain: effect on health-related quality of life" by Ranieri M, Sciuscio M, Cortese AM, Santamato A, Di Teo L, Ianieri G, Bellomo RG, Stasi M, Megna M.(1)

2. Anti inflammatory effects
In the evaluation of wheather The PUFAs of omega-3 and omega-6 series play a significant role in health and disease by generating potent modulatory molecules for inflammatory responses,
found that GLA and its metabolites also affect expression of various genes where by regulating the levels of gene products including matrix proteins. These gene products play a significant role in immune functions and also in cell death (apoptosis). The present review will emphasize the role of GLA in modulating inflammatory response, and hence its potential applications as an anti-inflammatory nutrient or adjuvant, according to "Gamma linolenic acid: an antiinflammatory omega-6 fatty acid" by Kapoor R, Huang YS.(2)

3. Brain tumor
In the investigation of the effects of oral consumption of gamma linolenic acid(GLA) and docosahexaenoic acid (DHA) on brain tumor fatty acid composition, showed that dietary supplementation of DHA containing oil could be an effective way to increase levels of long chain n-3 fatty acids in brain tumors and this increase may be mediated partly by up-regulation of FABP7 expression, according to "The influence of feeding linoleic, gamma-linolenic and docosahexaenoicacid rich oils on rat brain tumor fatty acids composition and fatty acidbinding protein 7 mRNA expression" by Nasrollahzadeh J, Siassi F, Doosti M, Eshraghian MR, Shokri F, Modarressi MH, Mohammadi-Asl J, Abdi K, Nikmanesh A, Karimian SM.(3)

4. Proliferation diseases
In the determination of a controversial dietary approaches focused on the diverse function of dihomo-dietary gamma-linolenic acid (DGLA) in anti-inflammation and anti-proliferation diseases, especially for cancers, found that hese compounds possess both anti-inflammatory and anti-proliferative properties. PGE1 could also induce growth inhibition and differentiation of cancer cells. Although the mechanism of DGLA has not yet been elucidated, it is significant to anticipate the antitumor potential benefits from DGLA, according to "Multiple roles of dihomo-gamma-linolenic acid against proliferation diseases" by Wang X, Lin H, Gu Y.(4)

5. Human health and nutrition
In the deiermination of weather a controversial dietary approaches has been the possible prophylactic role of dietary gamma-linolenic acid (GLA) in treating various chronic disease states, showed that these compounds possess both anti-inflammatory and antiproliferative properties. Although an optimal feeding regimen to maximize the potential benefits of dietary GLA has not yet been determined, it is the purpose of this review to summarize the most recent research that has focused on objectively and reproducibly determining the mechanism(s) by which GLA may ameliorate health problems, according to "Importance of dietarygamma-linolenic acid in human health and nutrition" by Fan YY, Chapkin RS.(5)

6. Skin protection
in the elucidation of the effect of GLA-rich oil on skin function, found that the mechanism of improvement of skin barrier has been associated with possible generation of anti-inflammatory metabolites from GLA. The clinical physician also confirmed that none of the subjects showed any noteworthy side effects. GLA-enriched food appears to be safe and to improve skin barrier function in subjects with dry skin conditions and mild atopic dermatitis, according to 'Dietary supplementation of gamma-linolenic acid improves skin parameters in subjects with dry skin and mild atopic dermatitis" by Kawamura A, Ooyama K, Kojima K, Kachi H, Abe T, Amano K, Aoyama T.(6)

7. Drug-sensitive and resistant tumor cells
In the investigation of weather dihomo-gamma-linolenic acid (DGLA) and AA, EPA and DHA have cytotoxic action on both vincristine-sensitive (KB-3-1) and resistant (KB-Ch(R)-8-5) cancer cells in vitro, indicated that GLA, DGLA, AA, EPA and DHA enhanced the uptake and decreased efflux in both drug-sensitive and drug-resistant cells and augmented the susceptibility of tumor cells especially, of drug-resistant cells to the cytotoxic action of vincristine. These results suggest that certain polyunsaturated fatty acids have tumoricidal action and are capable of enhancing the cytotoxic action of anti-cancer drugs specifically, on drug-resistant cells by enhancing drug uptake and reducing its efflux. Thus, polyunsaturated fatty acids either by themselves or in combination with chemotherapeutic drugs have the potential as anti-cancer molecules, according to "Effect of polyunsaturated fatty acids on drug-sensitive and resistant tumor cells in vitro" by Das UN, Madhavi N.(7)

8. Acute lung injury or acute respiratory distress syndrome (ARDS)
In the assessment of the effect of an enteral diet enriched with eicosapentaenoicacid (EPA), gamma-linolenic acid (GLA), and anti-oxidants on the incidence of organ dysfunction and nosocomial infections in septic patients with acute lung injury or acute respiratory distress syndrome (ARDS) compared with a standard enteral diet, found that A diet enriched with EPA, GLA, and anti-oxidants does not improve gas exchange or decrease the incidence of novel organ failures in critically ill septic patients with acute lung injury or ARDS. Patients treated with the EPA-GLA diet stayed in the ICU for less time, but we did not find any differences in infectious complications, according to "Effect of an enteral diet enriched with eicosapentaenoic acid, gamma-linolenic acid and anti-oxidants on the outcome of mechanically ventilated, critically ill, septic patients" by Grau-Carmona T, Morán-García V, García-de-Lorenzo A, Heras-de-la-Calle G, Quesada-Bellver B, López-Martínez J, González-Fernández C, Montejo-González JC, Blesa-Malpica A, Albert-Bonamusa I, Bonet-Saris A, Herrero-Meseguer JI, Mesejo A, Acosta J.(8)

9. Antineoplastic effects
In the investigation of the effect and the mechanism of gamma linolenic acid(GLA) treatment on human hepatocellular (HCC) cell lines, showed that GLA treatment has induced cell growth inhibition, ROS generation including lipid peroxidation, and HO-1 production for antioxidant protection against oxidative stress caused by GLA in Huh7 cells. GLA treatment should be considered as a therapeutic modality in patients with advanced HCC, according to "Antineoplastic effects of gamma linolenic Acid on hepatocellular carcinoma cell lines' by Itoh S, Taketomi A, Harimoto N, Tsujita E, Rikimaru T, Shirabe K, Shimada M, Maehara Y.(9)

10. Chronic myelogenous leukemia
In the testing the apoptotic effect of GLA on human chronic myelogenous leukemia K562 cells,
showed that the apoptosis could be inhibited by a pancaspase inhibitor (z-VAD-fmk), suggesting the involvement of caspases. Further, release of cytochrome c, activation of caspase-3 and cleavage of PARP were found in GLA-induced apoptosis.GLA treatment could also elevate lipid peroxidation in K562 cells, and antioxidant alpha-tocopherol could reverse the cytotoxicity of GLA. The saturated fatty acid SA, which did not exhibit significant increase in lipid peroxidation, also did not induce cytotoxicity. Intracellular GSH was also determined, and there was no marked change of GSH levels in cells after incubation with GLA compared with the control. These results demonstrate that GLA could induce apoptosis in K562 cells. Apoptosis is mediated by release of cytochrome c, activation of caspase-3. Lipid peroxidation may play a role in GLA cytotoxicity, according to "Gamma-linolenic acid induces apoptosis and lipid peroxidation in human chronic myelogenous leukemia K562 cells" by Ge H, Kong X, Shi L, Hou L, Liu Z, Li P.(10)

11. Etc.

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Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/19887043
(2) http://www.ncbi.nlm.nih.gov/pubmed/17168669
(3) http://www.ncbi.nlm.nih.gov/pubmed/19014610
(4) http://www.ncbi.nlm.nih.gov/pubmed/22333072
(5) http://www.ncbi.nlm.nih.gov/pubmed/9732298
(6) http://www.ncbi.nlm.nih.gov/pubmed/22123240
(7) http://www.ncbi.nlm.nih.gov/pubmed/21917129
(8) http://www.ncbi.nlm.nih.gov/pubmed/21474219
(9) http://www.ncbi.nlm.nih.gov/pubmed/20664735
(10) http://www.ncbi.nlm.nih.gov/pubmed/19356705

The Fabulous Smoothie of Coffee, Carrot and Green Tea for Prevention and Treatment of Cervical Dysplasia

Kyle J. Norton(Scholar, Master of Nutrient, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for reduced risk and treatment of cervical polyps
Yield: 2 servings (about 8 ounces each)
5/8 cup black coffee drink
1/2 cup carrot
1 cup green tea drink (Make from 4 grams of green tea, a slice of ginger and a cup of hot water lipped for 5 minutes, and let cool to room temperature)

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed. Add more green tea drink if needed

3. Serve immediately

The finding of a natural source for reduced risk and treatment of cervical polyps to replace the conventional medicine has been running into many obstacles, many ingredients showed initially with promising result in animal studies have not produced same potentials in either large sample size and mutli centers human trials.

Cervical dysplasia is a precancerous condition in which abnormal cell growth occurs on the surface lining of the cervix or endocervical canal.
Green Tea(1) and Wolfberry(4) Juice and Honey(6) in recent studies by renowned institution suggested that the combined ingredients may consist a potential effect for production of natural alternation in treating Cervical dysplasia

Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Due to its commercial values and health effects, green tea now has been cultivated all over the world in suitable climate. According to the Huazhong University of Science and Technology drinking more green tea may help to reduce the risk of cervical cancer or CINII/III in people of the Wufeng area(1). Dr. Ahn WS and colleagues in the study of the protective effects of green tea extracts (polyphenon E and EGCG), insisted that in a form of ointment and capsule green tea extracts are effective for treating cervical lesions with a 69% response rate(2). In the advancement of phase III clinical intervention trials conducted by University of Leicester, tea polyphenols tentatively supports the prevention of progression of prostate intraepithelial neoplasia, leukoplakia or premalignant cervical disease(3).

Tannin acid found abundantly in over-the-counter Indian tea, of green coffee beans and of the roasted coffee beans(4) also expressed strong binding capacity of cell surface carbohydrates in normal, premalignant, and malignant squamous epithelium of the human uterine cervix, according to the Dr,Davina JH and colleagues(5).

Beta-carotene (OR = 0.65) and zeaxanthin/lutein , the derivatives of carotenoids, found abundantly in carrot, are associated to reduce risk of cervical dysplasia in a case-control study in Japan(6). Higher serum level of alpha-carotene was significantly associated with decreased risk of cervical dysplasia after controlling for HPV infection(6).

According to Dr. Basta T and colleagues, insisted that normal vitamin A serum levels may have a protective effect against cervical carcinogenesis as .women with cervical intraepithelial neopiasia are found to have lower serum of vitamin A concentration in blood(7).

The effectiveness of Coffee, Carrot and Green Tea may serve as cornerstones of pharmaceutical target for further studies in production of a potential medication for Reduced Risk of Consequences of Cervical dysplasia with little or no adverse effects.

Women who are at increased risk of Cervical dysplasia due to family history,... may drink 1 cup daily and women with Cervical dysplasia should drink at least 4 cups a day, depending to the digestive toleration.
Life style and dietary patter change are recommended.

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References

(1) Case-control study of diet in patients with cervical cancer or precancerosis in Wufeng, a high incidence region in China by Jia Y1, Hu T, Hang CY, Yang R, Li X, Chen ZL, Mei YD, Zhang QH, Huang KC, Xiang QY, Pan XY, Yan YT, Wang XL, Wang SS, Hang Z,Tang FX, Liu D, Zhou J, Xi L, Wang H, Lu YP, Ma D, Wang SX, Li S.(PubMed)(2) Protective effects of green tea extracts (polyphenon E and EGCG) on human cervical lesions by Ahn WS1, Yoo J, Huh SW, Kim CK, Lee JM, Namkoong SE, Bae SM, Lee IP.(PubMed)
(3) Dietary polyphenolic phytochemicals--promising cancer chemopreventive agents in humans? A review of their clinical properties by Thomasset SC1, Berry DP, Garcea G, Marczylo T, Steward WP, Gescher AJ.(PubMed)
(4) Tannin content of tea and coffee by Savolainen H1.(PubMed)
(5) Tannic acid binding of cell surfaces in normal, premalignant, and malignant squamous epithelium of the human uterine cervix by Davina JH, Lamers GE, van Haelst UJ, Kenemans P, Stadhouders AM.(PubMed)
(6) Serum carotenoids and vitamins and risk of cervical dysplasia from a case-control study in Japan. by Nagata C1, Shimizu H, Yoshikawa H, Noda K, Nozawa S, Yajima A, Sekiya S, Sugimori H, Hirai Y, Kanazawa K, Sugase M, Kawana T.(PubMed)
(7) [Significance of vitamins A and E in the cervical intraepithelial neopiasia--CEN].[Article in Polish] by Basta T, Jach R, Streb J, Hosiawa W, Gawron I.(PubMed)

Most common Diseases of 50plus: Heart Disease(The Articles) - Heart Diseases' Diet

Heart Disease

Beside cancer, heart disease kills more than 2,000 Americans everyday. Approximately 60 million Americans have heart disease. There are many causes of heart disease. Anything that serves to damage the inner lining of blood vessels and impedes the transportation of oxygen and nutrition to the heart can be defined as a risk of heart disease.

Heart Diseases' Diet

Most heart diseases are preventable with a change of life style and healthy diet.
Unhealthy diet is a major cause of heart diseases resulting in the buildup of cholesterol and fat in the inner wall of arteries that narrows the arteries, impedes the circulation and eventually causes heart attacks.

To prevent heart diseases, your daily diet should contain:
1. Fiber
Fiber can be soluble or insoluble. As we mentioned in a previous article, soluble fiber can lower your LDL and raise your HDL cholesterol while insoluble fiber has no effect on cholesterol but promotes regular bowel movements. The intake of fatty foods causes the liver to release bile into the intestines to break down the fat. The soluble fiber will help eliminate the bile instead of returning it to the blood resulting in reduced amounts of cholesterol in the blood.

2. Reduce intake of saturated fat and trans fat
We know that saturated and trans fat are toxins causing cholesterol to build up in the arteries damaging the arterial wall and narrows the arterial passage in result of poor circulation and oxygen transportation to our body in result of high blood pressure as the heart has to work harder than normal in order to provide enough nutrition to the body`s cells. Eventually, the heart will fail and result in heart diseases. It is recommended that you reduce the intake of animal fat and increase the intake of cold water fish which is the best sources of omega 3 and 6 fatty acids that can help your cholesterol levels as well as lowering your blood pressure.

3. Diet high in complex carbohydrates
Vegetables, fruits, some beans and grains contain high amounts of plant pigments known as flavonoids that provide healthy protection against heart diseases. Unfortunately study shows that diets high in complex carbohydrate may increase the release of too much insulin to respond to carbohydrates in the diet. The type and amount of carbohydrate foods may need individual monitoring. Please consult with your doctor if you wish to include high amounts of complex carbohydrates in your diet.

4. Drink half of your body weight of water or juices in ounces
If you weigh 160 pounds then you are require to drink 80 ounces of water or juices to prevent the cells in our body to become dehydrated. Maintaining normal function of our body's cells is a healthy way to normalize high blood pressure.