Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Ursolic acid
Ursolic acid is a phytochemincal in the subclass of Triterpenoid, belonging to the group of Terpenes found abundantly in apples, basil, bilberries, cranberries, peppermint, lavender, oregano, hawthorn, prunes., etc.
Health Benefits
1. Multi-drug resistance cancers
In the study of the proliferation-inhibiting and apoptosis-inducing effects of ursolic acid (UA) and oleanolic acid (OA) on multi-drug resistance (MDR) cancer cells in vitro, indicated that Both UA and OA have antitumor effects on cancer cells with MDR, and the optimal effect is shown by UA on colonic cancer cells. Also, UA shows cell apoptosis-inducing effect on SW480, possibly by way of down-regulating the expressions of apoptosis antagonistic proteins, Bcl-2, Bcl-xL, and surviving, according to "Proliferation-inhibiting and apoptosis-inducing effects of ursolic acid and oleanolic acid on multi-drug resistance cancer cells in vitro" by Shan JZ, Xuan YY, Ruan SQ, Sun M.(1)
2. Skin fibroblast cells
In the observation of how ursolic and oleanolic acids can be used for the purpose of quality control of natural products used in dermatocosmetology as well as of various other therapeutic preparations, showed that Of the two isomeric compounds, UA showed a higher cytotoxic activity against HSF cells than did OA. Our investigations showed that OA, in view of its non-toxic nature, may be used as a supplementary factor for dermal preparations, according to "The effect of ursolic and oleanolic acids on human skin fibroblast cells" by Wójciak-Kosior M, Paduch R, Matysik-Woźniak A, Niedziela P, Donica H.(2)
3. Antibiotic resistance
In the investigation of antibiotic resistance effects of oleanolic acid (OA) and ursolic acid (UA), among bacterial pathogens (Pseudomonas aeruginosa, Listeria monocytogenes, Staphylococcus aureus and Staphylococcus epidermidis), found that Using FICI value estimation and the time-kill method it was demonstrated that in some combinations, the tested compounds acted in synergy to lower the susceptibility of S. aureus, S. epidermidis and L. monocytogenes to ampicillin and oxacillin, but no synergy was observed for P. aeruginosa, according to "Modulation of antibiotic resistance in bacterial pathogens by oleanolic acid and ursolic acid" by Kurek A, Nadkowska P, Pliszka S, Wolska KI.(3)
4. Cytotoxic activites
In the evaluation of the anti-proliferative capability of the derivatives of C-3 and C-28 positions of ursolic acid (UA). against HepG2, AGS, HT-29 and PC-3 cells by the MTT assay, showed the cytotoxic capacity of the compounds was: Group I
5. Hepatocellular carcinoma
In the study of the inhibitory effect and mechanisms of UA on the human hepatoma cell line SMMC-7721, indicated that the proliferation of SMMC-7721 cells was significantly inhibited in a dose- and time-dependent manner after UA treatment. UA induced cell cycle arrest and apoptosis. The DNA microarray analysis indicated that 64 genes were found to be markedly up- or down-expressed, including GDF15, SOD2, ATF3, and fos, according to "Ursolic acid induces human hepatoma cell line SMMC-7721 apoptosis via p53-dependent pathway" by Yu YX, Gu ZL, Yin JL, Chou WH, Kwok CY, Qin ZH, Liang ZQ.(5)
6. Bladder cancer
In the investigation of Ursolic acid (UA) anti-tumor properties against bladder cancer, found that the ceramide level was increased after UA treatment in T24 cells, and UA-induced AMPK activation and T24 cell apoptosis were inhibited by ceramide synthase inhibitor fumonisin B1, and was enhanced by exogenously adding cell permeable short-chain ceramide (C6), suggesting that ceramide might serve as an upstream signal for AMPK activation. Further, activation of AMPK by UA promoted c-Jun N-terminal kinase (JNK) activation, but inhibited mTOR complex 1 (mTORC1) signaling to cause survivin down-regulation, according to "Ursolic acid-induced AMP-activated protein kinase (AMPK) activation contributes to growth inhibition and apoptosis in human bladder cancer T24 cells" by Zheng QY, Yao C, Jin F, Zhang Y, Zhang GH.(6)
7. Anti cancers
In the investigation of QSAR models for predicting the activities of ursolic acid analogs against human lung (A-549) and CNS (SF-295) cancer cell lines, indicated that The QSAR study indicated that the LUMO energy, ring count, and solvent-accessible surface area were strongly correlated with anticancer activity. Similarly, the QSAR model for cytotoxic activity against the human CNS cancer cell line (SF-295) also showed a high correlation (r (2) = 0.99 and rCV(2) = 0.96), and indicated that dipole vector and solvent-accessible surface area were strongly correlated with activity. Ursolic acid analogs that were predicted to be active against these cancer cell lines by the QSAR models were semisynthesized and characterized on the basis of their (1)H and (13)C NMR spectroscopic data, and were then tested in vitro against the human lung (A-549) and CNS (SF-295) cancer cell lines. The experimental results obtained agreed well with the predicted values, according to "Pharmacophore, QSAR, and ADME based semisynthesis and in vitro evaluation of ursolic acid analogs for anticancer activity" by Kalani K, Yadav DK, Khan F, Srivastava SK, Suri N.(7)
8. Hippocrates, "Let food be thy medicine and medicine be thy food"
In the determination of the traditional medicine and diet on mankind through the ages for prevention and treatment of most chronic diseases, found that suggests that chronic inflammation mediates most chronic diseases, including cancer. More than other transcription factors, nuclear factor-kappaB (NF-κB) and STAT3 have emerged as major regulators of inflammation, cellular transformation, and tumor cell survival, proliferation, invasion, angiogenesis, and metastasis. Thus, agents ( avicins, betulinic acid, boswellic acid, celastrol, diosgenin, madecassic acid, maslinic acid, momordin, saikosaponins, platycodon, pristimerin, ursolic acid, and withanolide) that can inhibit NF-κB and STAT3 activation pathways have the potential to both prevent and treat cancer, according to "Targeting inflammatory pathways by triterpenoids for prevention and treatment of cancer" by Yadav VR, Prasad S, Sung B, Kannappan R, Aggarwal BB.(8)
9. Photoprotection
Inn the evaluation of photoprotective effects of against UVAR of triterpenoids, indicated that natural material-derived triterpenoids such as oleanolic acid can abrogate UVA-induced gene expression by raft stabilization. This effect depends on the structure of the molecule, because its isomer ursolic acid also integrates within the rafts without inhibiting ceramide formation and upregulation of gene expression, according to "Photoprotection against UVAR: effective triterpenoids require a lipid raft stabilizing chemical structure" by Bayer M, Proksch P, Felsner I, Brenden H, Kohne Z, Walli R, Duong TN, Götz C, Krutmann J, Grether-Beck S.(9)
10. Cardiotonic and antidysrhythmic effects
In the study of the cardiotonic and antidysrhythmic effects of four triterpenoid derivatives, namely oleanolic acid (OA), ursolic acid (UA), and uvaol (UV), isolated from the leaves of African wild olive (Olea europaea, subsp. africana) as well as methyl maslinate (MM) isolated from the leaves of Olea europaea (Cape cultivar), found that OA and UV isolated from wild African olive leaves, or crude extract containing all components, can provide a cheap and accessible source of additive to conventional treatment of hypertension, complicated by stenocardia and cardiac failure, according to "Cardiotonic and antidysrhythmic effects of oleanolic and ursolic acids, methyl maslinate and uvaol" by Somova LI, Shode FO, Mipando M.(10)
11. Etc.
Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/21799944
(2) http://www.ncbi.nlm.nih.gov/pubmed/22252762
(3)
(4) http://www.ncbi.nlm.nih.gov/pubmed/22370266
(5) http://www.ncbi.nlm.nih.gov/pubmed/20819578
(6) http://www.ncbi.nlm.nih.gov/pubmed/22387548
(7) http://www.ncbi.nlm.nih.gov/pubmed/22271093
(8) http://www.ncbi.nlm.nih.gov/pubmed/22069560
(9) http://www.ncbi.nlm.nih.gov/pubmed/21824200
(10) http://www.ncbi.nlm.nih.gov/pubmed/15070161
(11) http://www.ncbi.nlm.nih.gov/pubmed/12648829
Monday, June 6, 2016
The Holistic prevention, management and treatment of Polycystic Ovarian Syndrome: PCOs Complications
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Polycystic Ovarian Syndrome
Polycystic Ovarian Syndrome is defined as endocrinologic diseases among reproductive-age women caused by undeveloped follicles clumping on the ovaries that interferes with the function of the normal ovaries associated with a high risk for metabolic disorder(1) as resulting of enlarged ovaries(2), leading to hormone imbalance(excessive androgen and anti-müllerian hormone (AMH) )(1)(3)(4)(5), induced Hirsutism(6)(7), reproductive disorder(10(12)), risks of type 2 diabetes(9)(10)(11), metabolic syndrome(10)(12) and early cardiovascular disease(8)(13), acne(10)(14), endometrial cancer(18)(19),weight gain and obesity(15)(16)(17). The syndrome effects over 5% of women population or 1 in 20 women.
Unfortunately, according to studies, women with PCOs after the reproductive age, are associated to continuously increase risk of type II diabetes, with no increasingaltered glucose tolerance(20), CVD and hypertension(21).
PCOs Complications
1. Cardiovascular diseases
Beside cancer, heart disease kills more than 2,000 Americans everyday. Approximately 60 million Americans have heart disease. Women with PCOs have found to have increased risk of CVD due to hyperandrogenism in aggravation of abdominal obesity(211), insulin resistance forming(211), metabolic syndrome(212), type 2 diabetes(212)(213), altered plasma lipid profile(215), sympathovagal imbalance(216),.... According to University of Western Australia, treatment in uncorrelated components, such as insulin resistance, dyslipidaemia/hypertension or hyperandrogenaemia may be effectively to reduce differing cardiometabolic outcomes(214). Non-medical (normalization of weight, healthy lifestyle) and medical (metformin, thiazolidinediones, spironolactone, and statins) interventions were found effectively in reduced long-term risk for cardiovascular morbidity and mortality in women with PCOs(217).
Conflictingly, according to the study by Division of General Internal Medicine, Mayo Clinic, although women with PCOS weighed more than controls, there was no increased prevalence of other CV risk factors(218). The study also insisted that data on the incidence of CV events are lacking in PCOs' population(218)
2. Stroke
Besides cancer and heart diseases, stroke is the third leading cause of death. Approximate 1/4 of all stroke victims die as a direct result of the stroke or it's complications. Epidemiological evidences suggested that women with PCOs are at increased risk of stroke(220)(221). According to the review of 1340 articles, 5 follow-up studies published between 2000 and 2008 conducted by Leiden University Medical Center,, risk of stroke of women with PCOs was 2 folds higher in comparison of women with PCOS to women without PCOS(219).
3. Endometrial cancer
Endometrium is the inner lining of the mammalian uterus and very susceptible hormone change, particular to menstrual cycle. Endometrial cancer is a late adulthood cancer defined as a condition of which the cells of the endometrial lining of uterus have growth uncontrollable or become cancerous as a result of the alternation of cells DNA. It's the fourth most common cancer among women overall, after breast cancer, lung cancer, and bowel cancer.
women with polycystic ovary syndrome (PCOS) with altered estrogen and/or abnormality of levels progesterone (P4) at gene level(222), mutation gene(223)(227), abnormal levels of hormone (gonadotropins, estrogens, androgens, prolactin, andserotonin and progesterone),(228), hyperandrogenism(224), abnormal menstrual pattern(225), insulin resistance(228) associated with PCOS and obesity(226)(228), may contribute to increased endometrial cancer risk(222). Metformin(229) and combination of metformax, bromcriptine mesylate and metformin showed to improve clinical and metabolic syndrome in women with PCOS(230) with metformin alone through up-regulated tumor suppressor gene such as p53, cyclin D2 and BCL-2)(229).
4. Dyslipidemia
Dyslipidemia, one of metabolic syndrome has found to be associated to many patients with polycystic ovary syndrome (PCOS) risk factor(233), chracterized by elevated low-density lipoprotein (LDL), triglyceride levels and decreased high-density lipoprotein (HDL)(234), probably different metabolic aetiologies depending on DHEA-S metabolism, independent to insulin concentrations(235).
According to University of Brescia, Italy, use of the oral contraceptive for suppressed gonadotropin and androgen values and increased the levels of sex hormone binding globulin in women with PCOs showed a significant increase in triglycerides, high density lipoprotein (HDL) cholesterol system(232). Phytochemicals Berberine and monacolin showed effectively in a balanced lipid profile, through improve lipid metabolism in oral contraceptive induced hypercholesterolemia in women with or without PCOS(231).
5. Pregnancy risk
Women with PCOs are associated to higher rate of early pregnancy loss in comparison to women with reproductive problems(237). According to joint study conducted by Norwegian University of Science and St Olavs Hospital, wone with PCOs are associated to pre term delivery in twin pregnancies(236). Treatment with N-acetylcysteine (NAC) showed to enhance higher odds of getting pregnant with a live birth(238). In subfertile women with anovulatory PCOS, letrozole improved live birth and pregnancy rates in comparison to clomiphene citrate(239).
Adding phytochemical Cimicifugae Racemosae to clomiphene-induction cycles with timed intercourse significantly improved cycle outcomes and pregnancy rates in women with polycystic ovarian(241). Traditional Chinese formula, Danzhi Xiaoyao Pill (DXP) effectively enhanced the ovulation rate and the clinical pregnancy rate of 60% in anovulation infertility patients with PCOS complicated IR(242).
Dr. Ried K. at National Institute of Integrative Medicine, Hawthorn, Melbourne, VIC, Australia said " Chinese herbal medicine can improve pregnancy rates 2-fold within a 3-6 month period compared with Western medical fertility drug therapy, including women with PCOS"(240).
6. Infertility(See diseases associated to PCOs)
7. Higher risk of Gestational diabetes
Epidemiologocal studies, linking higher incidence of gestational diabetes mellitus (GDM) for women with PCOs has porduced inconsistent result(243)(244). Aristotle University suggested a improve properly designed studies are necessary before any recommendation to pregnant women with PCOS in regard to the risk of GDM(245), But according to Imperial College School of Medicine, there is a higher prevalence of polycystic ovarian morphology in women with a history of gestational diabetes(246).
8. Depression
Women with PCOS are found to have a higher rate of depression in comparison group women without(247)(248)(250). Psychologically, according to Institute of Psychology, Eötvös Loránd University, women with PCOs are associated with a great number of psychological symptoms, including (e.g. depression, anxiety, body image dissatisfaction, eating and sexual disorders, and low life satisfaction) due to gynaecological disorder of endocrine origin(249).
9. Liver diseases
Women with PCOS are associated to high risk of NAFLD(251)(252)(253). The suggested that some women with PCOS particularly those with an evidence of metabolic syndrome. should be considered to be screened for liver disease at an earlier age(254).
10. Diabetes(See diseases associated to PCOs)
Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
References
(1) Adiposity and metabolic dysfunction in polycystic ovary syndrome by Sam S.(PubMed)
(2) A "kiss" before conception: triggering ovulation with kisspeptin-54 may improve IVF by Young SL.(PubMed)
(3.) Androgen hyperfunction and excessive heterosexual hair growth in women, with special attention to the polycystic ovarian syndrome by Lunde O1.(PubMed)
(4) Expression of anti-Müllerian hormone in letrozole rat model of polycystic ovary syndrome by Du DF1, Li XL, Fang F, Du MR.(PubMed)
(5) [Serum levels of anti-muller hormone in women with polycystic ovary syndromeand healthy women of reproductive age].[Article in Bulgarian] by Parahuleva N, Pehlivanov B, Orbecova M, Deneva T, Uchikova E.(PubMed)
(6) [Current opinions on the etiology and pathophysiology of hirsutism].[Article in Polish] by Krysiak R1, Kedzia A, Okopień B.(PubMed)
(7) The clinical evaluation of hirsutism by Somani N1, Harrison S, Bergfeld WF.(PubMed)
(8) Polycystic ovary syndrome and insulin: our understanding in the past, present and future by Mayer SB1, Evans WS, Nestler JE.(PubMed)
(9) Association of mean platelet volume with androgens and insulin resistance in nonobese patients with polycystic ovary syndrome by Dogan BA1, Arduc A2, Tuna MM1, Karakılıc E1, Dagdelen I1, Tutuncu Y1, Berker D1, Guler S1.(PubMed)
(10) Approach to the patient: contraception in women with polycystic ovary syndrome by Yildiz BO1.(PubMed)
(11) Polycystic ovarian syndrome (PCOS): a significant contributor to the overall burden of type 2 diabetes in women by Talbott EO1, Zborowski JV, Rager JR, Kip KE, Xu X, Orchard TJ.(PubMed)
(12) Prevalence of vitamin D deficiency in Slovak women with polycystic ovary syndrome and its relation to metabolic and reproductive abnormalities by Figurová J1, Dravecká I, Javorský M, Petríková J, Lazúrová I.(PubMed)
(13) Role of Insulin Sensitizers on Cardiovascular Risk Factors in Polycystic Ovarian Syndrome: A Meta-Analysis by Thethi TK1, Katalenich B2, Nagireddy P3, Chabbra P4, Kuhadiya N5, Fonseca V1.(PubMed)
(14) Acne in hirsute women by Lumezi BG1, Pupovci HL1, Berisha VL1, Goçi AU2, Gerqari A3.(PubMed)
(15) Obesity and polycystic ovary syndrome by Naderpoor N1, Shorakae S, Joham A, Boyle J, De Courten B, Teede HJ.(PubMed)
(16) Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan by Teede H1, Deeks A, Moran L.(PubMed)
(17) Metabolic Evidence of Diminished Lipid Oxidation in Women With Polycystic Ovary Syndrome. by Whigham LD1, Butz DE2, Dashti H3, Tonelli M3, Johnson LK1, Cook ME2, Porter WP4, Eghbalnia HR5, Markley JL6, Lindheim SR7, Schoeller DA8, Abbott DH9, Assadi-Porter FM10.(PubMed)
(18) Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis by Barry JA1, Azizia MM1, Hardiman PJ2.(PubMed)
(19) Risk of cancer among women with polycystic ovary syndrome: a Danish cohort study by Gottschau M1, Kjaer SK2, Jensen A1, Munk C1, Mellemkjaer L3.(PubMed)
(20) Polycystic ovary syndrome: metabolic consequences and long-term management by Carmina E1.(PubMed)
(21) Arterial stiffness is increased in asymptomatic nondiabetic postmenopausal women with a polycystic ovary syndrome phenotype by Armeni E1, Stamatelopoulos K, Rizos D, Georgiopoulos G, Kazani M, Kazani A, Kolyviras A, Stellos K, Panoulis K, Alexandrou A, Creatsa M, Papamichael C, Lambrinoudaki I.(PubMed)
(211) Cardiovascular risk factors and events in women with androgen excess by Macut D1, Antić IB, Bjekić-Macut J.(PubMed)
(212) Assessment of cardiovascular risk and prevention of cardiovascular disease in women with the polycystic ovary syndrome: a consensus statement by the Androgen Excess and Polycystic Ovary Syndrome (AE-PCOS) Society by Wild RA1, Carmina E, Diamanti-Kandarakis E, Dokras A, Escobar-Morreale HF, Futterweit W, Lobo R, Norman RJ, Talbott E, Dumesic DA.(PubMed)
(213) Type 2 diabetes and cardiovascular disease in polycystic ovary syndrome: what are the risks and can they be reduced? by Tomlinson J1, Millward A, Stenhouse E, Pinkney J.(PubMed)
(214) Clustering of metabolic and cardiovascular risk factors in the polycystic ovary syndrome: a principal component analysis by Stuckey BG1, Opie N2, Cussons AJ3, Watts GF4, Burke V4.(PubMed)
(215) Cardiac fatty acid uptake and metabolism in the rat model of polycystic ovary syndrome by Tepavčević S1, Milutinović DV, Macut D, Stojiljković M, Nikolić M, Božić-Antić I, Ćulafić T, Bjekić-Macut J, Matić G, Korićanac G.(PubMed)
(216) Assessment of cardiovascular autonomic function in patients with polycystic ovary syndrome by Saranya K1, Pal GK, Habeebullah S, Pal P.(PubMed)
(217) Cardiovascular risk and subclinical cardiovascular disease in polycystic ovary syndrome by Bajuk Studen K1, Jensterle Sever M, Pfeifer M.(PubMed)
(218) Risk of cardiovascular events in patients with polycystic ovary syndrome by Iftikhar S1, Collazo-Clavell ML, Roger VL, St Sauver J, Brown RD Jr, Cha S, Rhodes DJ.(PubMed)
(220) Risk of coronary heart disease and risk of stroke in women with polycystic ovary syndrome: a systematic review and meta-analysis by Anderson SA1, Barry JA1, Hardiman PJ2(PubMed)
(221) Cardiovascular disease and risk factors in PCOS women of postmenopausal age: a 21-year controlled follow-up study by Schmidt J1, Landin-Wilhelmsen K, Brännström M, Dahlgren E.(PubMed)
(22) Endometrial stromal fibroblasts from women with polycystic ovary syndrome have impaired progesterone-mediated decidualization, aberrant cytokine profiles and promote enhanced immune cell migration in vitro by Piltonen TT1, Chen JC2, Khatun M3, Kangasniemi M3, Liakka A4, Spitzer T2, Tran N2, Huddleston H2, Irwin JC2, Giudice LC5.(PubMed)
(223) The effect of Metformin on endometrial tumor-regulatory genes and systemic metabolic parameters in polycystic ovarian syndrome - a proof-of-concept study by Shafiee MN1, Malik DA, Yunos RI, Atiomo W, Omar MH, Ghani NA, Hatta AZ, Seedhouse C, Chapman C, Mokhtar NM.(PubMed)
(224) Micronized estradiol and progesterone therapy in primary, preinvasiveendometrial cancer (1A/G1) in young women with polycystic ovarian syndrome by Stanosz S1, von Mach-Szczypiński J, Sieja K, Koœciuszkiewicz J.(PubMed)
(225) The percentages of endometrial hyperplasia and endometrial cancer among polycystic ovary syndrome (PCOS) patients presenting with abnormal menstrual pattern by Prakansamut N, Sirayapiwat P, Triratanachat S.(PubMed)
(226) PCOS and obesity: insulin resistance might be a common etiology for the development of type I endometrial carcinoma by Li X1, Shao R2(PubMed)
(227) Mesenchymal stem/progenitors and other endometrial cell types from women with polycystic ovary syndrome (PCOS) display inflammatory and oncogenic potential by Piltonen TT1, Chen J, Erikson DW, Spitzer TL, Barragan F, Rabban JT, Huddleston H, Irwin JC, Giudice LC.(PubMed)
(229) The effect of Metformin on endometrial tumor-regulatory genes and systemic metabolic parameters in polycystic ovarian syndrome - a proof-of-concept study by Shafiee MN1, Malik DA, Yunos RI, Atiomo W, Omar MH, Ghani NA, Hatta AZ, Seedhouse C, Chapman C, Mokhtar NM.(PubMed)
(230) Micronized estradiol and progesterone therapy in primary, preinvasive endometrial cancer (1A/G1) in young women with polycystic ovarian syndrome by Stanosz S1, von Mach-Szczypiński J, Sieja K, Koœciuszkiewicz J.(PubMed)
(231) Berberine and monacolin effects on the cardiovascular risk profile of women with oestroprogestin-induced hypercholesterolemia by Cicero AF1, Reggi A, Parini A, Morbini M, Rosticci M, Grandi E, Borghi C.(PubMed)
(232) Effects of long-term administration of an oral contraceptive containing ethinylestradiol and cyproterone acetate on lipid metabolism in women with polycystic ovary syndrome by Falsetti L1, Pasinetti E.(PubMed)
(233) Polycystic Ovary Syndrome and the Metabolic Syndrome by Julie L. Sharpless, MD(American diabeyes association)
(234) Pathophysiology and types of dyslipidemia in PCOS by Diamanti-Kandarakis E1, Papavassiliou AG, Kandarakis SA, Chrousos GP(PubMed)
(235) Dyslipidaemia in polycystic ovarian syndrome: different groups, different aetiologies? by Meirow D1, Raz I, Yossepowitch O, Brzezinski A, Rosler A, Schenker JG, Berry EM.(PubMed)
(236) Pregnancy and perinatal outcomes in women with polycystic ovary syndrome and twin births: a population-based cohort study by Løvvik TS1, Wikström AK, Neovius M, Stephansson O, Roos N, Vanky E.(PubMed)
(237) [Reproductive problems in women with PCOS, the impact of PAI-1 carriers of 4G PAI-1 polymorphism and BMI]. [Article in Russian] [No authors listed](PubMed)
(238) N-acetylcysteine for polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled clinical trials byThakker D1, Raval A2, Patel I3, Walia R4.(PubMed)
(239) Aromatase inhibitors for subfertile women with polycystic ovary syndrome by Franik S1, Kremer JA, Nelen WL, Farquhar C.(PubMed)
(240) Chinese herbal medicine for female infertility: an updated meta-analysis by Ried K1.(PubMed)
(241) Adding the phytoestrogen Cimicifugae Racemosae to clomiphene induction cycles with timed intercourse in polycystic ovary syndrome improves cycle outcomes and pregnancy rates - a randomized trial by Shahin AY1, Mohammed SA.(PubMed)
(242) [Effect of danzhi xiaoyao pill on ovulation induction of polycystic ovarian syndrome patients of pathogenic fire derived from stagnation of gan-qi]. [Article in Chinese] by Liu Y1, Mao LH.(PubMed)
(243) Prevalence of gestational diabetes mellitus in polycystic ovarian syndrome (PCOS) patients pregnant after ovulation induction with gonadotrophins by Vollenhoven B1, Clark S, Kovacs G, Burger H, Healy D.(PubMed)
(244) Prevalence of gestational diabetes mellitus and pregnancy outcomes in Asian women with polycystic ovary syndrome by Weerakiet S1, Srisombut C, Rojanasakul A, Panburana P, Thakkinstian A, Herabutya Y.(PubMed)
(245)
(246) The prevalence of polycystic ovaries in women with a history of gestational diabetes. Kousta E1, Cela E, Lawrence N, Penny A, Millauer B, White D, Wilson H, Robinson S, Johnston D, McCarthy M, Franks S.(PubMed)
(247) Reporting the rates of depression in polycystic ovary syndrome (PCOS) by Barry JA1, Kuczmierczyk AR, Hardiman PJ.(PubMed)
(248) Depression symptoms and body dissatisfaction association among polycystic ovary syndrome women by Pastore LM1, Patrie JT, Morris WL, Dalal P, Bray MJ.(PubMed)
(249) Psychological aspects of the polycystic ovary syndrome by Farkas J1, Rigó A, Demetrovics Z.(PubMed)
(250) Is having polycystic ovary syndrome a predictor of poor psychological function including anxiety and depression? by Deeks AA1, Gibson-Helm ME, Paul E, Teede HJ.(PubMed)
(251) Are women with polycystic ovarian syndrome at a high risk of non-alcoholic Fatty liver disease; a meta-analysis by Ramezani-Binabaj M1, Motalebi M2, Karimi-Sari H3, Rezaee-Zavareh MS1, Alavian SM4.(PubMed)
(252) Nonalcoholic fatty liver disease in women with polycystic ovary syndrome by Cerda C1, Pérez-Ayuso RM, Riquelme A, Soza A, Villaseca P, Sir-Petermann T, Espinoza M, Pizarro M, Solis N, Miquel JF, Arrese M.(PubMed)
(253) [Prevalence of nonalcoholic fatty liver disease in patients with polycystic ovary syndrome: a case-control study]. [Article in Chinese] by Zheng RH1, Ding CF.(PubMed)
(254) An association between non-alcoholic fatty liver disease and polycystic ovarian syndrome by Brzozowska MM1, Ostapowicz G, Weltman MD(PubMed)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Polycystic Ovarian Syndrome
Unfortunately, according to studies, women with PCOs after the reproductive age, are associated to continuously increase risk of type II diabetes, with no increasingaltered glucose tolerance(20), CVD and hypertension(21).
PCOs Complications
1. Cardiovascular diseases
Beside cancer, heart disease kills more than 2,000 Americans everyday. Approximately 60 million Americans have heart disease. Women with PCOs have found to have increased risk of CVD due to hyperandrogenism in aggravation of abdominal obesity(211), insulin resistance forming(211), metabolic syndrome(212), type 2 diabetes(212)(213), altered plasma lipid profile(215), sympathovagal imbalance(216),.... According to University of Western Australia, treatment in uncorrelated components, such as insulin resistance, dyslipidaemia/hypertension or hyperandrogenaemia may be effectively to reduce differing cardiometabolic outcomes(214). Non-medical (normalization of weight, healthy lifestyle) and medical (metformin, thiazolidinediones, spironolactone, and statins) interventions were found effectively in reduced long-term risk for cardiovascular morbidity and mortality in women with PCOs(217).
Conflictingly, according to the study by Division of General Internal Medicine, Mayo Clinic, although women with PCOS weighed more than controls, there was no increased prevalence of other CV risk factors(218). The study also insisted that data on the incidence of CV events are lacking in PCOs' population(218)
2. Stroke
Besides cancer and heart diseases, stroke is the third leading cause of death. Approximate 1/4 of all stroke victims die as a direct result of the stroke or it's complications. Epidemiological evidences suggested that women with PCOs are at increased risk of stroke(220)(221). According to the review of 1340 articles, 5 follow-up studies published between 2000 and 2008 conducted by Leiden University Medical Center,, risk of stroke of women with PCOs was 2 folds higher in comparison of women with PCOS to women without PCOS(219).
3. Endometrial cancer
Endometrium is the inner lining of the mammalian uterus and very susceptible hormone change, particular to menstrual cycle. Endometrial cancer is a late adulthood cancer defined as a condition of which the cells of the endometrial lining of uterus have growth uncontrollable or become cancerous as a result of the alternation of cells DNA. It's the fourth most common cancer among women overall, after breast cancer, lung cancer, and bowel cancer.
women with polycystic ovary syndrome (PCOS) with altered estrogen and/or abnormality of levels progesterone (P4) at gene level(222), mutation gene(223)(227), abnormal levels of hormone (gonadotropins, estrogens, androgens, prolactin, andserotonin and progesterone),(228), hyperandrogenism(224), abnormal menstrual pattern(225), insulin resistance(228) associated with PCOS and obesity(226)(228), may contribute to increased endometrial cancer risk(222). Metformin(229) and combination of metformax, bromcriptine mesylate and metformin showed to improve clinical and metabolic syndrome in women with PCOS(230) with metformin alone through up-regulated tumor suppressor gene such as p53, cyclin D2 and BCL-2)(229).
4. Dyslipidemia
Dyslipidemia, one of metabolic syndrome has found to be associated to many patients with polycystic ovary syndrome (PCOS) risk factor(233), chracterized by elevated low-density lipoprotein (LDL), triglyceride levels and decreased high-density lipoprotein (HDL)(234), probably different metabolic aetiologies depending on DHEA-S metabolism, independent to insulin concentrations(235).
According to University of Brescia, Italy, use of the oral contraceptive for suppressed gonadotropin and androgen values and increased the levels of sex hormone binding globulin in women with PCOs showed a significant increase in triglycerides, high density lipoprotein (HDL) cholesterol system(232). Phytochemicals Berberine and monacolin showed effectively in a balanced lipid profile, through improve lipid metabolism in oral contraceptive induced hypercholesterolemia in women with or without PCOS(231).
5. Pregnancy risk
Women with PCOs are associated to higher rate of early pregnancy loss in comparison to women with reproductive problems(237). According to joint study conducted by Norwegian University of Science and St Olavs Hospital, wone with PCOs are associated to pre term delivery in twin pregnancies(236). Treatment with N-acetylcysteine (NAC) showed to enhance higher odds of getting pregnant with a live birth(238). In subfertile women with anovulatory PCOS, letrozole improved live birth and pregnancy rates in comparison to clomiphene citrate(239).
Adding phytochemical Cimicifugae Racemosae to clomiphene-induction cycles with timed intercourse significantly improved cycle outcomes and pregnancy rates in women with polycystic ovarian(241). Traditional Chinese formula, Danzhi Xiaoyao Pill (DXP) effectively enhanced the ovulation rate and the clinical pregnancy rate of 60% in anovulation infertility patients with PCOS complicated IR(242).
Dr. Ried K. at National Institute of Integrative Medicine, Hawthorn, Melbourne, VIC, Australia said " Chinese herbal medicine can improve pregnancy rates 2-fold within a 3-6 month period compared with Western medical fertility drug therapy, including women with PCOS"(240).
6. Infertility(See diseases associated to PCOs)
7. Higher risk of Gestational diabetes
Epidemiologocal studies, linking higher incidence of gestational diabetes mellitus (GDM) for women with PCOs has porduced inconsistent result(243)(244). Aristotle University suggested a improve properly designed studies are necessary before any recommendation to pregnant women with PCOS in regard to the risk of GDM(245), But according to Imperial College School of Medicine, there is a higher prevalence of polycystic ovarian morphology in women with a history of gestational diabetes(246).
8. Depression
Women with PCOS are found to have a higher rate of depression in comparison group women without(247)(248)(250). Psychologically, according to Institute of Psychology, Eötvös Loránd University, women with PCOs are associated with a great number of psychological symptoms, including (e.g. depression, anxiety, body image dissatisfaction, eating and sexual disorders, and low life satisfaction) due to gynaecological disorder of endocrine origin(249).
9. Liver diseases
Women with PCOS are associated to high risk of NAFLD(251)(252)(253). The suggested that some women with PCOS particularly those with an evidence of metabolic syndrome. should be considered to be screened for liver disease at an earlier age(254).
10. Diabetes(See diseases associated to PCOs)
Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
References
(1) Adiposity and metabolic dysfunction in polycystic ovary syndrome by Sam S.(PubMed)
(2) A "kiss" before conception: triggering ovulation with kisspeptin-54 may improve IVF by Young SL.(PubMed)
(3.) Androgen hyperfunction and excessive heterosexual hair growth in women, with special attention to the polycystic ovarian syndrome by Lunde O1.(PubMed)
(4) Expression of anti-Müllerian hormone in letrozole rat model of polycystic ovary syndrome by Du DF1, Li XL, Fang F, Du MR.(PubMed)
(5) [Serum levels of anti-muller hormone in women with polycystic ovary syndromeand healthy women of reproductive age].[Article in Bulgarian] by Parahuleva N, Pehlivanov B, Orbecova M, Deneva T, Uchikova E.(PubMed)
(6) [Current opinions on the etiology and pathophysiology of hirsutism].[Article in Polish] by Krysiak R1, Kedzia A, Okopień B.(PubMed)
(7) The clinical evaluation of hirsutism by Somani N1, Harrison S, Bergfeld WF.(PubMed)
(8) Polycystic ovary syndrome and insulin: our understanding in the past, present and future by Mayer SB1, Evans WS, Nestler JE.(PubMed)
(9) Association of mean platelet volume with androgens and insulin resistance in nonobese patients with polycystic ovary syndrome by Dogan BA1, Arduc A2, Tuna MM1, Karakılıc E1, Dagdelen I1, Tutuncu Y1, Berker D1, Guler S1.(PubMed)
(10) Approach to the patient: contraception in women with polycystic ovary syndrome by Yildiz BO1.(PubMed)
(11) Polycystic ovarian syndrome (PCOS): a significant contributor to the overall burden of type 2 diabetes in women by Talbott EO1, Zborowski JV, Rager JR, Kip KE, Xu X, Orchard TJ.(PubMed)
(12) Prevalence of vitamin D deficiency in Slovak women with polycystic ovary syndrome and its relation to metabolic and reproductive abnormalities by Figurová J1, Dravecká I, Javorský M, Petríková J, Lazúrová I.(PubMed)
(13) Role of Insulin Sensitizers on Cardiovascular Risk Factors in Polycystic Ovarian Syndrome: A Meta-Analysis by Thethi TK1, Katalenich B2, Nagireddy P3, Chabbra P4, Kuhadiya N5, Fonseca V1.(PubMed)
(14) Acne in hirsute women by Lumezi BG1, Pupovci HL1, Berisha VL1, Goçi AU2, Gerqari A3.(PubMed)
(15) Obesity and polycystic ovary syndrome by Naderpoor N1, Shorakae S, Joham A, Boyle J, De Courten B, Teede HJ.(PubMed)
(16) Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan by Teede H1, Deeks A, Moran L.(PubMed)
(17) Metabolic Evidence of Diminished Lipid Oxidation in Women With Polycystic Ovary Syndrome. by Whigham LD1, Butz DE2, Dashti H3, Tonelli M3, Johnson LK1, Cook ME2, Porter WP4, Eghbalnia HR5, Markley JL6, Lindheim SR7, Schoeller DA8, Abbott DH9, Assadi-Porter FM10.(PubMed)
(18) Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis by Barry JA1, Azizia MM1, Hardiman PJ2.(PubMed)
(19) Risk of cancer among women with polycystic ovary syndrome: a Danish cohort study by Gottschau M1, Kjaer SK2, Jensen A1, Munk C1, Mellemkjaer L3.(PubMed)
(20) Polycystic ovary syndrome: metabolic consequences and long-term management by Carmina E1.(PubMed)
(21) Arterial stiffness is increased in asymptomatic nondiabetic postmenopausal women with a polycystic ovary syndrome phenotype by Armeni E1, Stamatelopoulos K, Rizos D, Georgiopoulos G, Kazani M, Kazani A, Kolyviras A, Stellos K, Panoulis K, Alexandrou A, Creatsa M, Papamichael C, Lambrinoudaki I.(PubMed)
(211) Cardiovascular risk factors and events in women with androgen excess by Macut D1, Antić IB, Bjekić-Macut J.(PubMed)
(212) Assessment of cardiovascular risk and prevention of cardiovascular disease in women with the polycystic ovary syndrome: a consensus statement by the Androgen Excess and Polycystic Ovary Syndrome (AE-PCOS) Society by Wild RA1, Carmina E, Diamanti-Kandarakis E, Dokras A, Escobar-Morreale HF, Futterweit W, Lobo R, Norman RJ, Talbott E, Dumesic DA.(PubMed)
(213) Type 2 diabetes and cardiovascular disease in polycystic ovary syndrome: what are the risks and can they be reduced? by Tomlinson J1, Millward A, Stenhouse E, Pinkney J.(PubMed)
(214) Clustering of metabolic and cardiovascular risk factors in the polycystic ovary syndrome: a principal component analysis by Stuckey BG1, Opie N2, Cussons AJ3, Watts GF4, Burke V4.(PubMed)
(215) Cardiac fatty acid uptake and metabolism in the rat model of polycystic ovary syndrome by Tepavčević S1, Milutinović DV, Macut D, Stojiljković M, Nikolić M, Božić-Antić I, Ćulafić T, Bjekić-Macut J, Matić G, Korićanac G.(PubMed)
(216) Assessment of cardiovascular autonomic function in patients with polycystic ovary syndrome by Saranya K1, Pal GK, Habeebullah S, Pal P.(PubMed)
(217) Cardiovascular risk and subclinical cardiovascular disease in polycystic ovary syndrome by Bajuk Studen K1, Jensterle Sever M, Pfeifer M.(PubMed)
(218) Risk of cardiovascular events in patients with polycystic ovary syndrome by Iftikhar S1, Collazo-Clavell ML, Roger VL, St Sauver J, Brown RD Jr, Cha S, Rhodes DJ.(PubMed)
(220) Risk of coronary heart disease and risk of stroke in women with polycystic ovary syndrome: a systematic review and meta-analysis by Anderson SA1, Barry JA1, Hardiman PJ2(PubMed)
(221) Cardiovascular disease and risk factors in PCOS women of postmenopausal age: a 21-year controlled follow-up study by Schmidt J1, Landin-Wilhelmsen K, Brännström M, Dahlgren E.(PubMed)
(22) Endometrial stromal fibroblasts from women with polycystic ovary syndrome have impaired progesterone-mediated decidualization, aberrant cytokine profiles and promote enhanced immune cell migration in vitro by Piltonen TT1, Chen JC2, Khatun M3, Kangasniemi M3, Liakka A4, Spitzer T2, Tran N2, Huddleston H2, Irwin JC2, Giudice LC5.(PubMed)
(223) The effect of Metformin on endometrial tumor-regulatory genes and systemic metabolic parameters in polycystic ovarian syndrome - a proof-of-concept study by Shafiee MN1, Malik DA, Yunos RI, Atiomo W, Omar MH, Ghani NA, Hatta AZ, Seedhouse C, Chapman C, Mokhtar NM.(PubMed)
(224) Micronized estradiol and progesterone therapy in primary, preinvasiveendometrial cancer (1A/G1) in young women with polycystic ovarian syndrome by Stanosz S1, von Mach-Szczypiński J, Sieja K, Koœciuszkiewicz J.(PubMed)
(225) The percentages of endometrial hyperplasia and endometrial cancer among polycystic ovary syndrome (PCOS) patients presenting with abnormal menstrual pattern by Prakansamut N, Sirayapiwat P, Triratanachat S.(PubMed)
(226) PCOS and obesity: insulin resistance might be a common etiology for the development of type I endometrial carcinoma by Li X1, Shao R2(PubMed)
(227) Mesenchymal stem/progenitors and other endometrial cell types from women with polycystic ovary syndrome (PCOS) display inflammatory and oncogenic potential by Piltonen TT1, Chen J, Erikson DW, Spitzer TL, Barragan F, Rabban JT, Huddleston H, Irwin JC, Giudice LC.(PubMed)
(229) The effect of Metformin on endometrial tumor-regulatory genes and systemic metabolic parameters in polycystic ovarian syndrome - a proof-of-concept study by Shafiee MN1, Malik DA, Yunos RI, Atiomo W, Omar MH, Ghani NA, Hatta AZ, Seedhouse C, Chapman C, Mokhtar NM.(PubMed)
(230) Micronized estradiol and progesterone therapy in primary, preinvasive endometrial cancer (1A/G1) in young women with polycystic ovarian syndrome by Stanosz S1, von Mach-Szczypiński J, Sieja K, Koœciuszkiewicz J.(PubMed)
(231) Berberine and monacolin effects on the cardiovascular risk profile of women with oestroprogestin-induced hypercholesterolemia by Cicero AF1, Reggi A, Parini A, Morbini M, Rosticci M, Grandi E, Borghi C.(PubMed)
(232) Effects of long-term administration of an oral contraceptive containing ethinylestradiol and cyproterone acetate on lipid metabolism in women with polycystic ovary syndrome by Falsetti L1, Pasinetti E.(PubMed)
(233) Polycystic Ovary Syndrome and the Metabolic Syndrome by Julie L. Sharpless, MD(American diabeyes association)
(234) Pathophysiology and types of dyslipidemia in PCOS by Diamanti-Kandarakis E1, Papavassiliou AG, Kandarakis SA, Chrousos GP(PubMed)
(235) Dyslipidaemia in polycystic ovarian syndrome: different groups, different aetiologies? by Meirow D1, Raz I, Yossepowitch O, Brzezinski A, Rosler A, Schenker JG, Berry EM.(PubMed)
(236) Pregnancy and perinatal outcomes in women with polycystic ovary syndrome and twin births: a population-based cohort study by Løvvik TS1, Wikström AK, Neovius M, Stephansson O, Roos N, Vanky E.(PubMed)
(237) [Reproductive problems in women with PCOS, the impact of PAI-1 carriers of 4G PAI-1 polymorphism and BMI]. [Article in Russian] [No authors listed](PubMed)
(238) N-acetylcysteine for polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled clinical trials byThakker D1, Raval A2, Patel I3, Walia R4.(PubMed)
(239) Aromatase inhibitors for subfertile women with polycystic ovary syndrome by Franik S1, Kremer JA, Nelen WL, Farquhar C.(PubMed)
(240) Chinese herbal medicine for female infertility: an updated meta-analysis by Ried K1.(PubMed)
(241) Adding the phytoestrogen Cimicifugae Racemosae to clomiphene induction cycles with timed intercourse in polycystic ovary syndrome improves cycle outcomes and pregnancy rates - a randomized trial by Shahin AY1, Mohammed SA.(PubMed)
(242) [Effect of danzhi xiaoyao pill on ovulation induction of polycystic ovarian syndrome patients of pathogenic fire derived from stagnation of gan-qi]. [Article in Chinese] by Liu Y1, Mao LH.(PubMed)
(243) Prevalence of gestational diabetes mellitus in polycystic ovarian syndrome (PCOS) patients pregnant after ovulation induction with gonadotrophins by Vollenhoven B1, Clark S, Kovacs G, Burger H, Healy D.(PubMed)
(244) Prevalence of gestational diabetes mellitus and pregnancy outcomes in Asian women with polycystic ovary syndrome by Weerakiet S1, Srisombut C, Rojanasakul A, Panburana P, Thakkinstian A, Herabutya Y.(PubMed)
(245)
(246) The prevalence of polycystic ovaries in women with a history of gestational diabetes. Kousta E1, Cela E, Lawrence N, Penny A, Millauer B, White D, Wilson H, Robinson S, Johnston D, McCarthy M, Franks S.(PubMed)
(247) Reporting the rates of depression in polycystic ovary syndrome (PCOS) by Barry JA1, Kuczmierczyk AR, Hardiman PJ.(PubMed)
(248) Depression symptoms and body dissatisfaction association among polycystic ovary syndrome women by Pastore LM1, Patrie JT, Morris WL, Dalal P, Bray MJ.(PubMed)
(249) Psychological aspects of the polycystic ovary syndrome by Farkas J1, Rigó A, Demetrovics Z.(PubMed)
(250) Is having polycystic ovary syndrome a predictor of poor psychological function including anxiety and depression? by Deeks AA1, Gibson-Helm ME, Paul E, Teede HJ.(PubMed)
(251) Are women with polycystic ovarian syndrome at a high risk of non-alcoholic Fatty liver disease; a meta-analysis by Ramezani-Binabaj M1, Motalebi M2, Karimi-Sari H3, Rezaee-Zavareh MS1, Alavian SM4.(PubMed)
(252) Nonalcoholic fatty liver disease in women with polycystic ovary syndrome by Cerda C1, Pérez-Ayuso RM, Riquelme A, Soza A, Villaseca P, Sir-Petermann T, Espinoza M, Pizarro M, Solis N, Miquel JF, Arrese M.(PubMed)
(253) [Prevalence of nonalcoholic fatty liver disease in patients with polycystic ovary syndrome: a case-control study]. [Article in Chinese] by Zheng RH1, Ding CF.(PubMed)
(254) An association between non-alcoholic fatty liver disease and polycystic ovarian syndrome by Brzozowska MM1, Ostapowicz G, Weltman MD(PubMed)
The Fabulous Smoothie of Green Tea, Blueberry and Mango for Prevention and Treatment of Stomach Cancer/Gastric Cancer
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
The smoothie for prevention and treatment of Stomach Cancer/Gastric Cancer
Yield: 2 serving (about 8 ounce each)
1 cup blueberry
1/2 cup mango
1 cup green tea drink (Make from 4 grams of green tea and a cup of hot water lipped for 5 minutes, and let cool to room temperature)
1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately
The finding of a natural source for treatment of Stomach Cancer/Gastric Cancer has been running into many obstacles, many ingredients showed initially with promising result in animal studies have not produced same potentials in large sample size and mutli centers human trials.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
The smoothie for prevention and treatment of Stomach Cancer/Gastric Cancer
Yield: 2 serving (about 8 ounce each)
1 cup blueberry
1/2 cup mango
1 cup green tea drink (Make from 4 grams of green tea and a cup of hot water lipped for 5 minutes, and let cool to room temperature)
1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately
The finding of a natural source for treatment of Stomach Cancer/Gastric Cancer has been running into many obstacles, many ingredients showed initially with promising result in animal studies have not produced same potentials in large sample size and mutli centers human trials.
Stomach cancer is defined as condition of abnormal growth of the mucus-producing cells of the inside lining of the stomach. Adenocarcinoma is the most common type of stomach cancer.
Recent studies back by renowned institutions, conveyed that green tea(1), blueberry(4) and mango(7) may be holding a key for extracting natural ingredient for reduced early onset and treatment of Stomach Cancer/Gastric Cancer. According to the Sichuan University, regular green tea consumption is associated to a minor inverse association of risk of gastric cancer in all population-based case-control studies(1).
Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Due to its commercial values and health effects,
green tea now has been cultivated all over the world in suitable climate.
The University of Utah School of Medicine study propose the prevention effects of green tea against the early onset of cancers overall(2).
In fact, the conflict results between green tea intake and gastric cancer risk may be due to how the drink was served in temperature wise. One study had shown a significantly lowered GC risk when tea was served warm to cold. Another study also showed a significantly risk with lukewarm tea(3).
Resveratrol, a phytochemical in the class of Stilbenoids, found abundantly in blueberry and grape is also associated to reduce risk of gastric cancer, according to the Cook County Hospital(4).
Dr. Riles WL and colleagues in the investigation of the resveratrol effect against gastric cancer, indicated that the antioxidant up regulating cancer suppressive gene p53 in in SNU-1 and AGS cancer cell lines in different mechanisms(5).
Other study suggested the effectiveness of resveratrol for treatment of gastric cancer probable through intracellular signaling in growth arrest and apoptosis against tumor progression(6).
Gallic acid is a phytochemical in the class of Phenolic acids, found abundantly in mango and strawberries also inhibited gastric cancer cell lines through inhibition of NF-κB, the pro inflammatory cytokines activity(7), in immunoreactivity assay of cytoskeletal F-actin(8).
Dr. Yoshioka K and researchers at the Mie University, suggested, in human stomach cancer KATO III cells, gallic acid exhibited anti the KATO III cell line through induction of apoptosis in concentration- and time-dependen(9).Gallic acid is a phytochemical in the class of Phenolic acids, found abundantly in mango and strawberries also inhibited gastric cancer cell lines through inhibition of NF-κB, the pro inflammatory cytokines activity(7), in immunoreactivity assay of cytoskeletal F-actin(8).
The finding of the effectiveness of Green Tea, Blueberry and Mango may serve as cornerstones of pharmaceutical target for further studies as well as a potential medication for treatment of Stomach Cancer/Gastric Cancer
People who are at increased risk of Stomach Cancer/Gastric Cancer , due to family history, auto immunity,....should drink the juices at least one a day. People with Stomach Cancer/Gastric Cancer should drink the juice as much as as they can depending to digestive toleration.
Life style and diet pattern change are recommended.
References
(1) Green tea and gastric cancer risk: meta-analysis of epidemiologic studies by Zhou Y1, Li N, Zhuang W, Liu G, Wu T, Yao X, Du L, Wei M, Wu X(PubMed)
(2) Coffee, tea, caffeine intake, and the risk of cancer in the PLCO cohort by Hashibe M1,2, Galeone C3, Buys SS4, Gren L1, Boffetta P5, Zhang ZF6, La Vecchia C7.(PubMed)
(3) Green tea and the risk of gastric cancer: epidemiological evidence by Hou IC, Amarnani S, Chong MT, Bishayee A.(PubMed)
(4) Resveratrol regulates cellular PKC alpha and delta to inhibit growth and induce apoptosis in gastric cancer cells by Atten MJ1, Godoy-Romero E, Attar BM, Milson T, Zopel M, Holian O.(PubMed)
(5) Resveratrol engages selective apoptotic signals in gastric adenocarcinoma cells by Riles WL1, Erickson J, Nayyar S, Atten MJ, Attar BM, Holian O.(PubMed)
(6) Resveratrol: A potential challenger against gastric cancer by Zulueta A1, Caretti A1, Signorelli P1, Ghidoni R1.(PubMed)
(7) Gallic acid inhibits gastric cancer cells metastasis and invasive growth via increased expression of RhoB, downregulation of AKT/small GTPase signals and inhibition of NF-κB activity by Ho HH1, Chang CS, Ho WC, Liao SY, Lin WL, Wang CJ.(PubMed)
(8) Anti-metastasis effects of gallic acid on gastric cancer cells involves inhibition of NF-kappaB activity and downregulation of PI3K/AKT/small GTPase signals by Ho HH1, Chang CS, Ho WC, Liao SY, Wu CH, Wang CJ.(PubMed)
(9) Induction of apoptosis by gallic acid in human stomach cancer KATO III and colon adenocarcinoma COLO 205 cell lines by Yoshioka K1, Kataoka T, Hayashi T, Hasegawa M, Ishi Y, Hibasami H.(PubMed)
The Obesity' Research and Studies of Human chorionic gonadotropin (HCG) and treatment of obesity
Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Obesity is a medical condition of excess body fat accumulated overtime, while overweight is a condition of excess body weight relatively to the height. According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered over weight, while a BMI of over 30 is an indication of obesity. According to the statistic, 68% of American population are either overweight or obese.
You can calculate your BMI index BMI= weight (kg)/ height (m2)
The Research and Studies of Human chorionic gonadotropin (HCG) and treatment of obesity
Human chorionic gonadotropin or human chorionic gonadotrophin (hCG) is a hormone produced during pregnancy, made by the developing embryo afterconception.In a double-blind randomized trial using injections of HCG or placebo,researchers found that weight loss was identical between the two groups, and there was no evidence for differential effects on hunger, mood or localized body measurements. Placebo injections, therefore, appear to be as effective as HCG in the treatment of obesity(1)
Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
(1) "Human chorionic gonadotropin (HCG) in the treatment of obesity: a critical assessment of the Simeons method" by Greenway FL, Bray GA.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Obesity is a medical condition of excess body fat accumulated overtime, while overweight is a condition of excess body weight relatively to the height. According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered over weight, while a BMI of over 30 is an indication of obesity. According to the statistic, 68% of American population are either overweight or obese.
You can calculate your BMI index BMI= weight (kg)/ height (m2)
The Research and Studies of Human chorionic gonadotropin (HCG) and treatment of obesity
Human chorionic gonadotropin or human chorionic gonadotrophin (hCG) is a hormone produced during pregnancy, made by the developing embryo afterconception.In a double-blind randomized trial using injections of HCG or placebo,researchers found that weight loss was identical between the two groups, and there was no evidence for differential effects on hunger, mood or localized body measurements. Placebo injections, therefore, appear to be as effective as HCG in the treatment of obesity(1)
Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
(1) "Human chorionic gonadotropin (HCG) in the treatment of obesity: a critical assessment of the Simeons method" by Greenway FL, Bray GA.
Most common Diseases of 50plus: Heart Disease(The Articles) - Aspirin: Friend or Foe?
Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Beside cancer, heart disease kills more than 2,000 Americans everyday. Approximately 60 million Americans have heart disease. There are many causes of heart disease. Anything that serves to damage the inner lining of blood vessels and impedes the transportation of oxygen and nutrition to the heart can be defined as a risk of heart disease.
Heart Diseases - Aspirin: Friend or Foe?
There are many causes of heart disease. Anything that serves to damage the inner lining of blood vessels and impedes the transportation of oxygen and nutrition to the heart can be defined as a risk of heart disease. You might have heard "taking an Aspirin a day will keep your heart attacks away". In fact, Aspirin does help your heart. the salicyca acid in aspirin helps to keep bloods cells from clumping together and sticking to the arterial wall. This reduces the risk of heart diseases. Here are some reasons to be cautious about aspirin therapy.
Before discussing the benefits and side effects of aspirin, there are some people who should not take aspirin. These include:
a. Allergies to ASA
b. last trimester of pregnancy
c. prone to bleeding
d. has an active peptic ulcer
e. taking blood thinner medication.
1. Aspirin indeed helps your blood from clotting. If you suffer any bleeding, taking aspirin will make bleeding harder to stop. Study show that aspirin might increase the bleeding complication. If you are taking any blood thinner medication or you have an ulcer, please consult with your doctor before taking aspirin. For people suffering from hemorrhages (this is the loss of blood from the circulatory system or internal bleeding taking aspirin) they would do more harm than good.
2. Aspirin increases the risk of bleeding and hemorrhagic strokes that are caused by blood vessels bursting in or around your brain. Therefore do not assume that taking an aspirin a day would do no harm. Please consult with with your doctor before starting aspirin therapy.
3. Study shows that aspirin does not work well with people with high cholesterol levels. People with cholesterol levels over 220 respond poorly to aspirin therapy. Therefore, if your cholesterol level is over 220 you might need to find some other therapy to lower the risk of heart diseases.
Aspirin also causes some side affects such as heartburn, indigestion and mild-to-moderate abdominal or stomach cramps.
Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Heart Disease
Heart Diseases - Aspirin: Friend or Foe?
There are many causes of heart disease. Anything that serves to damage the inner lining of blood vessels and impedes the transportation of oxygen and nutrition to the heart can be defined as a risk of heart disease. You might have heard "taking an Aspirin a day will keep your heart attacks away". In fact, Aspirin does help your heart. the salicyca acid in aspirin helps to keep bloods cells from clumping together and sticking to the arterial wall. This reduces the risk of heart diseases. Here are some reasons to be cautious about aspirin therapy.
Before discussing the benefits and side effects of aspirin, there are some people who should not take aspirin. These include:
a. Allergies to ASA
b. last trimester of pregnancy
c. prone to bleeding
d. has an active peptic ulcer
e. taking blood thinner medication.
1. Aspirin indeed helps your blood from clotting. If you suffer any bleeding, taking aspirin will make bleeding harder to stop. Study show that aspirin might increase the bleeding complication. If you are taking any blood thinner medication or you have an ulcer, please consult with your doctor before taking aspirin. For people suffering from hemorrhages (this is the loss of blood from the circulatory system or internal bleeding taking aspirin) they would do more harm than good.
2. Aspirin increases the risk of bleeding and hemorrhagic strokes that are caused by blood vessels bursting in or around your brain. Therefore do not assume that taking an aspirin a day would do no harm. Please consult with with your doctor before starting aspirin therapy.
3. Study shows that aspirin does not work well with people with high cholesterol levels. People with cholesterol levels over 220 respond poorly to aspirin therapy. Therefore, if your cholesterol level is over 220 you might need to find some other therapy to lower the risk of heart diseases.
Aspirin also causes some side affects such as heartburn, indigestion and mild-to-moderate abdominal or stomach cramps.
Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Anti Ageing Tips: Clinical proven in Regainning Youthfulness of Your Hands
Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
According to Dr. Rhoda Narins, MD, professor of dermatology at the NYU School of Medicine, your hands are one of the first places where we see the signs of aging, and also the area most people neglect when it comes to skin care. According to WebMD,, The like rings in a tree trunk, lines, creases, dark spots, and bulging veins on the back of your hands are the sneaky little tattletales that give away your age!(4).
The below tips have been proven through our clinical studies of over 400 subjects between age of 57 - 63. If you are in this age, you can expect the same results(a)(b)(c).
A. Dehydroascorbic acid (DHA) and vitamin E and A(1)
1. The chemical reaction of Dehydroascorbic acid (DHA)
Vitamin C + Water -----> Dehydroascorbic acid (DHA ) + 2e- +2H+
2. Vitamin E chemical structure
The α-tocopherol form of vitamin E
3. Vitamin A: C20H30O
The equipment and Preparation
1. One bottle of synthetic vitamin C 100x 500mg tablets. You can purchase this in any pharmacy for about $5.00
2. A bottle of vitamin E purified oil (You can only buy it from any pharmacy for $10) (We used provitamin E produced by Jamieson, due to complaints of irritation and stickiness of many tested subjects, You can also buy it at any pharmacy and super market for about $20 for a jar of 60ml)
3. A jar of provitamin A produced by Jamieson, due to complaints of irritation and stickiness of many tested subjects on vitamin A purofied oil, You can also buy it at any pharmacy and super market for about $15 for a jar of 120 ml)
4. A small bottle carries 100mL of warm tap water or still-water if desire.
5. A roll of bounty or a half hand size sponge.
6. A pair of plastic glove.
Please Note, Kyle J. Norton and Associates DO NOT receive funding from Jamieson(The giant vitamins company)
How to make Dehydroascorbic acid (DHA) 4% concentration
Day one
Put 8 tablets of synthetic vitamin C into the bottle which carries 100 mL of water[(8x500mg)/100mL=4000mg/100,000mg=4/100=4% concentration of Dehydroascorbic acid (DHA)] on the day before application to make sure all vitamin C tablets are dissolved.
How to Regain Youthfulness of Your Hand
The next day
Put on your glove. Shake the bottle well. Pour some Dehydroascorbic acid (DHA ) onto a piece of fold-twice bounty paper towels.
Apply the solutions 3 times a days
Application first of Dehydroascorbic acid (DHA) 4% concentration to induce skin cleansing through its detoxified, antioxidant and cell and collagen regeneration effects by rubbing against the skin of the effects area with little pressure for about one minutes. Apply more solution if require. Wait for 5 minutes then apply vitamin E directly and generously onto fingers and the back of your hands. Wait for 5 minutes, do the same with vitamin A. Wait another 5 minutes reapply more solution of vitamin E between the knuckles, knuckles and joints of your fingers.
After applying, clean the sponge if used and glove, return and store the bottle of solution and vitamin E. A into first aid box in room temperature. Replace the solution of Dehydroascorbic acid (DHA ) every ten days to retain accurate concentration.
What to expect
1. In the first few days of application
The back of hand regain the youthful figure.
The wrinkles, lines, creases, on your back of your hand and fine line of knuckles and finger joints begin to recede
2. In a few weeks
Depending to types of skin and severity of the effected areas, and according to our clinical study,
the combination of solution regain your hands youthfulness up to 80%. According to the study of ages between 57 - 62, approximately, 80% of tested subjects regain the youthful figure of the hands, 50% in removal of skin chapping, lines, creases, etc., and 75% on reduced visibility of bulging veins on the back of hands, probably through Dehydroascorbic acid (DHA) 4% concentration and vitamin E and A skin cleansing and detoxified, antioxidant and cell and collagen regeneration effects).
Here are the results of 58 years old test subject after 12 weeks of study
a. Picture on the table
B. Picture against the wall
Millions have been spent in our studies, we provide this information free and do not ask for anything in return. You promise to tell everyone you know about this webpage and retweet it, so they do not waste any more money on ineffective commercial products.
Precautions
1. Always testing your topical skin solution, including Dehydroascorbic acid (DHA ) and vitamin E for allergic reaction, by applying a tiny portion onto your wrist for 5 minutes. Do not use the solution if there is.
2. Although there were no adverse effect in our study, please make sure you always wear gloves before applying, as higher concentration than that ofDehydroascorbic acid (DHA) 4% concentration has been shown to cause brownness on the finger nails.
3. The Dehydroascorbic acid (DHA) 4% concentration has been shown to cause yellowness on the surface of some metal (very old) sinks, please make sure your test it to avoid the same messes.
4. Higher concentration of the solution has been used in skin tanning industry, please make that Dehydroascorbic acid (DHA) 4% concentration is completely absorbed(about 5- 10 minutes) into your skin before going to the extreme sun.
5. If the solutions get into your eyes, use tap water to clear them.
6. Do not attempt to make higher than Dehydroascorbic acid (DHA) 4% concentration solution, as it has not been tested.
All articles written by Kyle J. Norton are for information & education only, please consult your Doctor & Related field specialist before applying. If you have any questions about this article, please email at Kylenorton@live.ca
Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
References
(a) http://kylejnorton.blogspot.ca/2014/06/dehydroascorbic-acid-dhavitamin-c.html
(b) http://kylejnorton.blogspot.ca/2014/04/skin-aging-in-vitamin-e-points-of-view.html
(c) http://kylejnorton.blogspot.ca/2014/08/vitamin-dehydroascorbic-acid-dha-and.html
(1) http://kylejnorton.blogspot.ca/2014/10/anti-skin-aging-in-dehydroascorbic-acid.html
(2) http://kylejnorton.blogspot.ca/2014/04/skin-aging-in-vitamin-points-of-view.html
(3) http://kylejnorton.blogspot.ca/2014/04/skin-aging-in-vitamin-e-points-of-view.html
(4) A Handy Way to Look Years Younger(WebMD)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
According to Dr. Rhoda Narins, MD, professor of dermatology at the NYU School of Medicine, your hands are one of the first places where we see the signs of aging, and also the area most people neglect when it comes to skin care. According to WebMD,, The like rings in a tree trunk, lines, creases, dark spots, and bulging veins on the back of your hands are the sneaky little tattletales that give away your age!(4).
The below tips have been proven through our clinical studies of over 400 subjects between age of 57 - 63. If you are in this age, you can expect the same results(a)(b)(c).
A. Dehydroascorbic acid (DHA) and vitamin E and A(1)
1. The chemical reaction of Dehydroascorbic acid (DHA)
Vitamin C + Water -----> Dehydroascorbic acid (DHA ) + 2e- +2H+
2. Vitamin E chemical structure
The α-tocopherol form of vitamin E
3. Vitamin A: C20H30O
The equipment and Preparation
1. One bottle of synthetic vitamin C 100x 500mg tablets. You can purchase this in any pharmacy for about $5.00
2. A bottle of vitamin E purified oil (You can only buy it from any pharmacy for $10) (We used provitamin E produced by Jamieson, due to complaints of irritation and stickiness of many tested subjects, You can also buy it at any pharmacy and super market for about $20 for a jar of 60ml)
3. A jar of provitamin A produced by Jamieson, due to complaints of irritation and stickiness of many tested subjects on vitamin A purofied oil, You can also buy it at any pharmacy and super market for about $15 for a jar of 120 ml)
4. A small bottle carries 100mL of warm tap water or still-water if desire.
5. A roll of bounty or a half hand size sponge.
6. A pair of plastic glove.
Please Note, Kyle J. Norton and Associates DO NOT receive funding from Jamieson(The giant vitamins company)
How to make Dehydroascorbic acid (DHA) 4% concentration
Day one
Put 8 tablets of synthetic vitamin C into the bottle which carries 100 mL of water[(8x500mg)/100mL=4000mg/100,000mg=4/100=4% concentration of Dehydroascorbic acid (DHA)] on the day before application to make sure all vitamin C tablets are dissolved.
How to Regain Youthfulness of Your Hand
The next day
Put on your glove. Shake the bottle well. Pour some Dehydroascorbic acid (DHA ) onto a piece of fold-twice bounty paper towels.
Apply the solutions 3 times a days
Application first of Dehydroascorbic acid (DHA) 4% concentration to induce skin cleansing through its detoxified, antioxidant and cell and collagen regeneration effects by rubbing against the skin of the effects area with little pressure for about one minutes. Apply more solution if require. Wait for 5 minutes then apply vitamin E directly and generously onto fingers and the back of your hands. Wait for 5 minutes, do the same with vitamin A. Wait another 5 minutes reapply more solution of vitamin E between the knuckles, knuckles and joints of your fingers.
After applying, clean the sponge if used and glove, return and store the bottle of solution and vitamin E. A into first aid box in room temperature. Replace the solution of Dehydroascorbic acid (DHA ) every ten days to retain accurate concentration.
What to expect
1. In the first few days of application
The back of hand regain the youthful figure.
The wrinkles, lines, creases, on your back of your hand and fine line of knuckles and finger joints begin to recede
2. In a few weeks
Depending to types of skin and severity of the effected areas, and according to our clinical study,
the combination of solution regain your hands youthfulness up to 80%. According to the study of ages between 57 - 62, approximately, 80% of tested subjects regain the youthful figure of the hands, 50% in removal of skin chapping, lines, creases, etc., and 75% on reduced visibility of bulging veins on the back of hands, probably through Dehydroascorbic acid (DHA) 4% concentration and vitamin E and A skin cleansing and detoxified, antioxidant and cell and collagen regeneration effects).
Here are the results of 58 years old test subject after 12 weeks of study
a. Picture on the table
B. Picture against the wall
Millions have been spent in our studies, we provide this information free and do not ask for anything in return. You promise to tell everyone you know about this webpage and retweet it, so they do not waste any more money on ineffective commercial products.
Precautions
1. Always testing your topical skin solution, including Dehydroascorbic acid (DHA ) and vitamin E for allergic reaction, by applying a tiny portion onto your wrist for 5 minutes. Do not use the solution if there is.
2. Although there were no adverse effect in our study, please make sure you always wear gloves before applying, as higher concentration than that ofDehydroascorbic acid (DHA) 4% concentration has been shown to cause brownness on the finger nails.
3. The Dehydroascorbic acid (DHA) 4% concentration has been shown to cause yellowness on the surface of some metal (very old) sinks, please make sure your test it to avoid the same messes.
4. Higher concentration of the solution has been used in skin tanning industry, please make that Dehydroascorbic acid (DHA) 4% concentration is completely absorbed(about 5- 10 minutes) into your skin before going to the extreme sun.
5. If the solutions get into your eyes, use tap water to clear them.
6. Do not attempt to make higher than Dehydroascorbic acid (DHA) 4% concentration solution, as it has not been tested.
All articles written by Kyle J. Norton are for information & education only, please consult your Doctor & Related field specialist before applying. If you have any questions about this article, please email at Kylenorton@live.ca
Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
References
(a) http://kylejnorton.blogspot.ca/2014/06/dehydroascorbic-acid-dhavitamin-c.html
(b) http://kylejnorton.blogspot.ca/2014/04/skin-aging-in-vitamin-e-points-of-view.html
(c) http://kylejnorton.blogspot.ca/2014/08/vitamin-dehydroascorbic-acid-dha-and.html
(1) http://kylejnorton.blogspot.ca/2014/10/anti-skin-aging-in-dehydroascorbic-acid.html
(2) http://kylejnorton.blogspot.ca/2014/04/skin-aging-in-vitamin-points-of-view.html
(3) http://kylejnorton.blogspot.ca/2014/04/skin-aging-in-vitamin-e-points-of-view.html
(4) A Handy Way to Look Years Younger(WebMD)
Food therapy - Vegetables - Cabbage (Brassica oleracea)
Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Cabbage
Cabbage is a species of Brassica oleracea belong to the family Brassicaceae (or Cruciferae), native to the Mediterranean region along the seacoast. It has a short stem of which is crowded a mass of leaves, usually green but in some varieties, it may be red or purplish.
Nutrients
1. Carbohydrates
2.Fibers 3. Omega
3 fatty acid
4. Protein
5. Vitamin A
6.Thiamine (Vitamin B1)
7. Riboflavin (Vitamin B2)
8. Niacin (Vitamin B3)
9. Pantothenic acid (B5)
10.Vitamin B6
11. Folate (Vitamin B9)
12. Vitamin C
13. Calcium
14.I ron
15. Magnesium
16. Phosphorus
17. Potassium
18. Tryptophan
19. Zinc
20. Etc.
Health Benefits
A. Health Benefits according to studies
1. Breast Engorgement
Hot and cold compress and cabbage leaves have demonstrated the activities in decreasing breast engorgement and pain in postnatal mothers during the first two weeks following childbirth, according to the study of "A Comparison of Cabbage Leaves vs. Hot and Cold Compresses in the Treatment of Breast Engorgement" by Smriti Arora, Manju Vatsa, and Vatsla Dadhwal(a)
2. Cardiovascular health
Cabbage in steam cooking and other vegetable such as collard greens, kale, mustard greens, broccoli, green bell pepper has exerted the ability in lowering the recirculation of bile acids results in utilization of cholesterol to synthesize bile acid and reduced fat absorption and may be beneficial in preventing cardiovascular disease, cancer and improve public health, according to the study of "Steam cooking significantly improves in vitro bile acid binding of collard greens, kale, mustard greens, broccoli, green bell pepper, and cabbage" by Kahlon TS, Chiu MC, Chapman MH.(b)
3. Prostate cancer Brassica vegetables are associated with reduced prostate cancer risk, including broccoli, cabbage, mustard and collard greens, and bok choy, contain glucosinolates by breaking down products of which are potent modulators of xenobiotic-metabolizing enzymes that protect DNA from damage, according to the study of "Brassica vegetables and prostate cancer risk: a review of the epidemiological evidence" by Kristal AR, Lampe JW.(c)
4. Cancer prevention Brassica vegetables have shown the inverse associations between the consumption of brassica's and risk of lung cancer, stomach cancer, all cancers taken together due to certain hydrolysis products of glucosinolates, according to the study of "Brassica vegetables and cancer prevention. Epidemiology and mechanisms" by van Poppel G, Verhoeven DT, Verhagen H, Goldbohm RA.(d)
5. Etc.
B. Health benefits according to the concentration
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Cabbage
Cabbage is a species of Brassica oleracea belong to the family Brassicaceae (or Cruciferae), native to the Mediterranean region along the seacoast. It has a short stem of which is crowded a mass of leaves, usually green but in some varieties, it may be red or purplish.
Nutrients
1. Carbohydrates
2.Fibers 3. Omega
3 fatty acid
4. Protein
5. Vitamin A
6.Thiamine (Vitamin B1)
7. Riboflavin (Vitamin B2)
8. Niacin (Vitamin B3)
9. Pantothenic acid (B5)
10.Vitamin B6
11. Folate (Vitamin B9)
12. Vitamin C
13. Calcium
14.I ron
15. Magnesium
16. Phosphorus
17. Potassium
18. Tryptophan
19. Zinc
20. Etc.
Health Benefits
A. Health Benefits according to studies
1. Breast Engorgement
Hot and cold compress and cabbage leaves have demonstrated the activities in decreasing breast engorgement and pain in postnatal mothers during the first two weeks following childbirth, according to the study of "A Comparison of Cabbage Leaves vs. Hot and Cold Compresses in the Treatment of Breast Engorgement" by Smriti Arora, Manju Vatsa, and Vatsla Dadhwal(a)
2. Cardiovascular health
Cabbage in steam cooking and other vegetable such as collard greens, kale, mustard greens, broccoli, green bell pepper has exerted the ability in lowering the recirculation of bile acids results in utilization of cholesterol to synthesize bile acid and reduced fat absorption and may be beneficial in preventing cardiovascular disease, cancer and improve public health, according to the study of "Steam cooking significantly improves in vitro bile acid binding of collard greens, kale, mustard greens, broccoli, green bell pepper, and cabbage" by Kahlon TS, Chiu MC, Chapman MH.(b)
3. Prostate cancer Brassica vegetables are associated with reduced prostate cancer risk, including broccoli, cabbage, mustard and collard greens, and bok choy, contain glucosinolates by breaking down products of which are potent modulators of xenobiotic-metabolizing enzymes that protect DNA from damage, according to the study of "Brassica vegetables and prostate cancer risk: a review of the epidemiological evidence" by Kristal AR, Lampe JW.(c)
4. Cancer prevention Brassica vegetables have shown the inverse associations between the consumption of brassica's and risk of lung cancer, stomach cancer, all cancers taken together due to certain hydrolysis products of glucosinolates, according to the study of "Brassica vegetables and cancer prevention. Epidemiology and mechanisms" by van Poppel G, Verhoeven DT, Verhagen H, Goldbohm RA.(d)
5. Etc.
B. Health benefits according to the concentration
1. Vitamin K
a. Degenerative diseases of ageing
Long-term vitamin K inadequacy may reduce the function of supporting the carboxylation of at least some of these Gla-protein that can lead the development of degenerative diseases of ageing including osteoporosis and atherosclerosis, according to the study of "Vitamin K, osteoporosis and degenerative diseases of ageing" by Cees Vermeer and Elke Theuwissen(1)
b. Intracranial bleeding
In a study in the 4-year study period, 16/64 (25%) of the infants admitted with intracranial bleeding had late intracranial VKDB, resulting in an overall incidence of 2.1/100,000 live births (95% confidence interval 1.2-3.5) conducted by University Medical Center Utrecht(2) indicated that Intracranial bleeding may be associated with vitamin K deficiency
2. vitamin C
a. Asthma
Vitamin C is one of the key antioxidant vitamins which is abundant in the extracellular fluid lining the lung and low vitamin C intake has been associated with pulmonary dysfunction, such as asthma, according to the study of "Vitamin Csupplementation for asthma" by Kaur B, Rowe BH, Arnold E.(3)
b. DNA Damage
Ascorbic acid (AA), known as vitamin C, has important antioxidant vitamin has exerted the activity in preventing (imazalil)IMA-induced cause of DNA damage, according to the stuyd of "The protective role of ascorbic acid on imazalil-induced genetic damage assessed by the cytogenetic tests' by Türkez H, Aydin E.(4)
3. Dietary fiber
a. Obesity
Since it contains high amount of fiber, it makes the stomach feeling fullness longer, thus reducing the risk food craving, according to the study of "The role ofdietary fiber in the development and treatment of childhood obesity" by Kimm SY.(5)
b. Diabetes
Carrot contains high amount of fiber which helps to release the glucose slowly into blood stream as it has an inverse relationship with the prevalence of the metabolic syndrome and may contribute to both the prevention and treatment of type 2diabetes mellitu, according to the study of "[Dietary fibers: current trends and health benefits in the metabolic syndrome and type 2 diabetes].[Article in Portuguese]" by Mello VD, Laaksonen DE(6)
4. Etc.
C. Other health benefits
1. Respiratory Papillomatosis
Cabbage is used as foods to treat recurrent respiratory papillomatosis, due to high amount of I3C (indole-3-carbinol,), according to the study of "Recurrent respiratory papillomatosis: an overview of current thinking and treatment' by Goon P, Sonnex C, Jani P, Stanley M, Sudhoff H.(7)
2. Colon cancer
Indole-3-carbinol found in cabbage if you combination with genistein enhance gastrointestinal health thus reducing the risk of colon cancer, according to the study of "A combination of indol-3-carbinol and genistein synergistically induces apoptosis in human colon cancer HT-29 cells by inhibiting Akt phosphorylation and progression of autophagy" by Nakamura Y, Yogosawa S, Izutani Y, Watanabe H, Otsuji E, Sakai T.(8)
3. Omega 3 fatty acid
Cabbage reduces the risk of cardiovascular diseases by controlling the secretion of bad cholesterol, due to high amount of Omega 3 fatty acid, according to the study of "The Omega-3 Index as a risk factor for cardiovascular diseases' by von Schacky C.(9)
4. Etc.
Side effects
1. No Known side effect.
Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Sources
(a) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2763679/
(b) http://www.ncbi.nlm.nih.gov/pubmed/19083431
(c) http://www.ncbi.nlm.nih.gov/pubmed/12235639
(d) http://www.ncbi.nlm.nih.gov/pubmed/10736624
(1) http://mi.rsmjournals.com/content/17/1/19.abstract
(3) http://www.ncbi.nlm.nih.gov/pubmed/19160185
(4) http://www.ncbi.nlm.nih.gov/pubmed/21986888
(5) http://www.ncbi.nlm.nih.gov/pubmed/7494672
(6) http://www.ncbi.nlm.nih.gov/pubmed/19768242
(7) http://www.ncbi.nlm.nih.gov/pubmed/18046565
(8) http://www.ncbi.nlm.nih.gov/pubmed/19909554
(9) http://www.ncbi.nlm.nih.gov/pubmed/21726658
a. Degenerative diseases of ageing
Long-term vitamin K inadequacy may reduce the function of supporting the carboxylation of at least some of these Gla-protein that can lead the development of degenerative diseases of ageing including osteoporosis and atherosclerosis, according to the study of "Vitamin K, osteoporosis and degenerative diseases of ageing" by Cees Vermeer and Elke Theuwissen(1)
b. Intracranial bleeding
In a study in the 4-year study period, 16/64 (25%) of the infants admitted with intracranial bleeding had late intracranial VKDB, resulting in an overall incidence of 2.1/100,000 live births (95% confidence interval 1.2-3.5) conducted by University Medical Center Utrecht(2) indicated that Intracranial bleeding may be associated with vitamin K deficiency
2. vitamin C
a. Asthma
Vitamin C is one of the key antioxidant vitamins which is abundant in the extracellular fluid lining the lung and low vitamin C intake has been associated with pulmonary dysfunction, such as asthma, according to the study of "Vitamin Csupplementation for asthma" by Kaur B, Rowe BH, Arnold E.(3)
b. DNA Damage
Ascorbic acid (AA), known as vitamin C, has important antioxidant vitamin has exerted the activity in preventing (imazalil)IMA-induced cause of DNA damage, according to the stuyd of "The protective role of ascorbic acid on imazalil-induced genetic damage assessed by the cytogenetic tests' by Türkez H, Aydin E.(4)
3. Dietary fiber
a. Obesity
Since it contains high amount of fiber, it makes the stomach feeling fullness longer, thus reducing the risk food craving, according to the study of "The role ofdietary fiber in the development and treatment of childhood obesity" by Kimm SY.(5)
b. Diabetes
Carrot contains high amount of fiber which helps to release the glucose slowly into blood stream as it has an inverse relationship with the prevalence of the metabolic syndrome and may contribute to both the prevention and treatment of type 2diabetes mellitu, according to the study of "[Dietary fibers: current trends and health benefits in the metabolic syndrome and type 2 diabetes].[Article in Portuguese]" by Mello VD, Laaksonen DE(6)
4. Etc.
C. Other health benefits
1. Respiratory Papillomatosis
Cabbage is used as foods to treat recurrent respiratory papillomatosis, due to high amount of I3C (indole-3-carbinol,), according to the study of "Recurrent respiratory papillomatosis: an overview of current thinking and treatment' by Goon P, Sonnex C, Jani P, Stanley M, Sudhoff H.(7)
2. Colon cancer
Indole-3-carbinol found in cabbage if you combination with genistein enhance gastrointestinal health thus reducing the risk of colon cancer, according to the study of "A combination of indol-3-carbinol and genistein synergistically induces apoptosis in human colon cancer HT-29 cells by inhibiting Akt phosphorylation and progression of autophagy" by Nakamura Y, Yogosawa S, Izutani Y, Watanabe H, Otsuji E, Sakai T.(8)
3. Omega 3 fatty acid
Cabbage reduces the risk of cardiovascular diseases by controlling the secretion of bad cholesterol, due to high amount of Omega 3 fatty acid, according to the study of "The Omega-3 Index as a risk factor for cardiovascular diseases' by von Schacky C.(9)
4. Etc.
Side effects
1. No Known side effect.
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Sources
(a) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2763679/
(b) http://www.ncbi.nlm.nih.gov/pubmed/19083431
(c) http://www.ncbi.nlm.nih.gov/pubmed/12235639
(d) http://www.ncbi.nlm.nih.gov/pubmed/10736624
(1) http://mi.rsmjournals.com/content/17/1/19.abstract
(3) http://www.ncbi.nlm.nih.gov/pubmed/19160185
(4) http://www.ncbi.nlm.nih.gov/pubmed/21986888
(5) http://www.ncbi.nlm.nih.gov/pubmed/7494672
(6) http://www.ncbi.nlm.nih.gov/pubmed/19768242
(7) http://www.ncbi.nlm.nih.gov/pubmed/18046565
(8) http://www.ncbi.nlm.nih.gov/pubmed/19909554
(9) http://www.ncbi.nlm.nih.gov/pubmed/21726658
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