Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Obesity is a medical condition of excess body fat accumulated overtime, while overweight is a condition of excess body weight relatively to the height. According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered over weight, while a BMI of over 30 is an indication of obesity. According to the statistic, 68% of American population are either overweight or obese.
You can calculate your BMI index BMI= weight (kg)/ height (m2)
Uric acid, the form of ions and salts is a by product of chemical after the body breaks down purines, the substance is found in many foods, including Asparagus, Bacon, Beef, Bluefish, Bouillon, Calf tongue, Carp, Cauliflower, Chicken, Chicken soup, Codfish, Crab, Duck, Goose, etc.. High levels of uric acid in blood serum can be harmful, leading to gout and forming of kidney stones.
The association of Obesity with Increased Uric Acid
1. Acccording to the study of "Serum uric acid as an obesity-related indicator in early adolescence" by Oyama C, Takahashi T, Oyamada M, Oyamada T, Ohno T, Miyashita M, Saito S, Komatsu K, Takashina K, Takada G. (Source from Department of Pediatrics, Akita University School of Medicine, Akita, Japan. Tohoku J Exp Med. 2006 Jul;209(3):257-62), posted in PubMed, researchers found that In general, children are evaluated as obesity, when POW is equal to or more than 20% (>or= 20%). Serum uric acid levels are positively correlated with obesity-related indicators, BMI and POW, in both boys and girls. Serum uric acid levels of the subjects with high POW (>or= 20%) are significantly higher than those of the subjects with low POW (< 20%) in both boys and girls. These results suggest that serum uric acid levels are significantly increased with obesity and could be used as one of obesity-related indicators even in early adolescence.
2. In an abstract of study of "Recent trends of hyperuricemia and obesity in Japanese male adolescents, 1991 through 2002" by Ogura T, Matsuura K, Matsumoto Y, Mimura Y, Kishida M, Otsuka F, Tobe K. (Source from Health and Medical Center, Okayama University, Okayama, Japan. Metabolism. 2004 Apr;53(4):448-53), posted in PubMed, researchers found rhat Hyperuricemia was related to the presence of other risk factors, including hypercholesterolemia, liver function abnormality, and hypertension. The frequencies of such abnormalities were higher than euuricemic subjects and this trend was notable in the most recent students enrolled from 1999 through 2002. Hyperuricemia was even found in the group of non-obese male adolescents. Taking into consideration that hyperuricemia is associated with a high prevalence of lifestyle-related diseases in adults, it is of great importance to prevent hyperuricemia at the early stage in Japanese adolescents.
3. In a study of "[Uric acid nephrolithiasis]", [Article in French], by Dussol B.(Source from Centre de néphrologie et de transplantation rénale, hôpital de la Conception, 13385 Marseille Cedex 05. bertrand.dussol@ap-hm, Rev Prat. 2011 Mar;61(3):389-92), posted in PubMed, researcher indicated that Its frequency will increase in the next decades because of the ageing and the increasing prevalence of obesity and type 2 diabetes mellitus. The pathophysiologic defect is an excessively acidic urine pH rather than hyperuricosuria. Undissociated uric acid is poorly soluble in acidic urines (pH < 5.5) but solubility increases when sodium urate forms at higher pH. Insulin resistance may contribute to the development of acidic urine because of higher net acid excretion. Because uric acid kidney stones are radiolucent, diagnosis is based on echography and tomodensitometry. Medical management strategies focus primarily on alkali treatment and/or decreasing hyper-uricosuria.
4. According to a study of "Uric acid nephrolithiasis" by Liebman SE, Taylor JG, Bushinsky DA. (Source from University of Rochester School of Medicine and Dentistry, Nephrology Division, Strong Memorial Hospital, Rochester, NY 14642, USA. scott_liebman@urmc.rochester.edu, Curr Rheumatol Rep. 2007 Jun;9(3):251-7.), posted in PubMed, researchers found that Uric acidnephrolithiasis is typically found in individuals with a low urine pH and a normal concentration of urinary uric acid. Patients with a history of gout are at greater risk of forming uric acid stones, as are patients with obesity, diabetes, or the complete metabolic syndrome. The unifying renal tubular abnormality of these disorders appears to be the excretion of abnormally acidic urine. This article focuses on the relationship of these disorders to the development of uric acid stones.
5. According to a study of "Relation of uric acid with components of metabolic syndrome before and after Roux-en-Y gastric bypass in morbidly obese subjects" by Serpa Neto A, Rossi FM, Valle LG, Teixeira GK, Rossi M. (Source from Division of Clinical and Surgical Treatment of Obesity, Faculdade de Medicina do ABC, Santo André, SP, Brazil. aryserpa@terra.com.br, Arq Bras Endocrinol Metabol. 2011 Feb;55(1):38-45.), posted in PubMed, researchers indicated in abstract that Concentrations of uric acid were associated with the prevalence of metabolic abnormalities in this sample of morbidly obese patients. Also, weight loss after RYGBP can reduce uric acid levels and the prevalence of hyperuricemia.
6. Etc.
Treatments of Obesity and Increased Uric Acid
1. According to the abstract of the study of "Obesity and urolithiasis" by Asplin JR. (Source from Litholink Corporation, Chicago, IL 60612, USA. jasplin@litholink.com, Adv Chronic Kidney Dis. 2009 Jan;16(1):11-20), posted in PubMed, researchers stated that Obesity can increase stone risk in multiple ways. Excess nutritional intake increases traffic of lithogenic substances such as calcium, oxalate, and uric acid. Metabolic syndrome, commonly associated withobesity, alters renal acid-base metabolism, resulting in a lower urine pH andincreased risk of uric acid stone disease......, Certainly, the many health risks ofobesity, including urolithiasis, necessitate weight loss, but recognition of the potential complications of such therapies is required to prevent induction of new and equally severe medical problems. The optimal approach to weight control that minimizes stone risk needs to be determined.
2. In a study of "Body size and 24-hour urine composition" by Taylor EN, Curhan GC. (Source from Renal Division and Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. entaylor@partners.org, Am J Kidney Dis. 2006 Dec;48(6):905-15), posted in PubMed, researchers filed the conclusion of Positive associations between BMI and urinary calcium excretion likely are due to differences in animal protein and sodium intake. The greater incidence of kidney stones in the obese may be due to an increase in uric acid nephrolithiasis.
3. In abstract of the study of "Benefits of sustained moderate weight loss inobesity" by Pasanisi F, Contaldo F, de Simone G, Mancini M. (Source from Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy. pasanisi@unina.itm Nutr Metab Cardiovasc Dis. 2001 Dec;11(6):401-6.), posted in PubMed, researchers found that a large number of obese patients may be sensitive to a modest weight loss even without the achievement of ideal body weight. Sustained moderate weight loss by itself is definitely beneficial in obesity(especially "malignant" and "morbid" obesity), but also in diabetes, hypertension, hyperlipidaemia, cardiorespiratory diseases and other chronic degenerative diseases associated with any degree of excess body fat.
4. Etc.
Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Wednesday, June 8, 2016
The Obesity' Research and Studies - Effect of weight reduction on cardiovascular risk factors
Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Obesity is a medical condition of excess body fat accumulated overtime, while overweight is a condition of excess body weight relatively to the height. According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered over weight, while a BMI of over 30 is an indication of obesity. According to the statistic, 68% of American population are either overweight or obese.
You can calculate your BMI index BMI= weight (kg)/ height (m2)
Overweight or obese is aleady proven to be associated with an increased risk for the development of non-insulin-dependent diabetes mellitus, hypertension, and cardiovascular disease, etc. In the study of the effect of a low calorie diet in combination with oral supplementation by vitamins, minerals, probiotics and human chorionic gonadotropin (hCG, 125-180 IUs) on the body composition, lipid profile and CD34-positive cells in circulation. During this dieting program, the following parameters were assessed weekly for all participants: fat free mass, body fat, BMI, extracellular/intracellular water, total body water and basal metabolic rate. For part of participants blood chemistry parameters and circulating CD34-positive cells were determined before and after dieting. The data indicated that the treatments not only reduced body fat mass and total mass but also improved the lipid profile. The changes in body composition correlated with the level of lipoproteins responsible for the increased cardiovascular risk factors. These changes in body composition and lipid profile parameters coincided with the improvement of circulatory progenitor cell numbers(1)
Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
(1) "Effect of weight reduction on cardiovascular risk factors and CD34-positive cells in circulation" by Mikirova NA, Casciari JJ, Hunninghake RE, Beezley MM.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Obesity is a medical condition of excess body fat accumulated overtime, while overweight is a condition of excess body weight relatively to the height. According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered over weight, while a BMI of over 30 is an indication of obesity. According to the statistic, 68% of American population are either overweight or obese.
You can calculate your BMI index BMI= weight (kg)/ height (m2)
Overweight or obese is aleady proven to be associated with an increased risk for the development of non-insulin-dependent diabetes mellitus, hypertension, and cardiovascular disease, etc. In the study of the effect of a low calorie diet in combination with oral supplementation by vitamins, minerals, probiotics and human chorionic gonadotropin (hCG, 125-180 IUs) on the body composition, lipid profile and CD34-positive cells in circulation. During this dieting program, the following parameters were assessed weekly for all participants: fat free mass, body fat, BMI, extracellular/intracellular water, total body water and basal metabolic rate. For part of participants blood chemistry parameters and circulating CD34-positive cells were determined before and after dieting. The data indicated that the treatments not only reduced body fat mass and total mass but also improved the lipid profile. The changes in body composition correlated with the level of lipoproteins responsible for the increased cardiovascular risk factors. These changes in body composition and lipid profile parameters coincided with the improvement of circulatory progenitor cell numbers(1)
Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
(1) "Effect of weight reduction on cardiovascular risk factors and CD34-positive cells in circulation" by Mikirova NA, Casciari JJ, Hunninghake RE, Beezley MM.
Most Common Diseases of Men of 50Plus - Testosterone Deficiency - The Causes
Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Testosterone is a male hormone, besides promoting libido, it has other important functions such as maintain muscle mass and forming bone, and regulating heart muscle and cholesterol. It also helps to improve the oxygen levels throughout the body as well as controlling blood glucose and strengthening the immune system. In this article, we will discuss what causes low levels of testosterone.
1. Aging
As we mentioned in the other articles, human aging is the biological and pathological processes that vary from person to person and that are controllable to some degree. Starting at age 40, levels of testosterone start to diminish, the levels of the by-product prolactin of testosterone of men increases, stimulating the production of the enzyme 5-alpha reductase that causes the conversion of testosterone to gihydro-testosterones DHT thus triggering low levels of testosterone.
2. DHEA deficiency
DHEA (dehydroepiandrosterone) is a substance made by the adrenal gland. It is the precursor of the sex steroids estrogen and testosterone. DHEA has some male hormone effects and deficiency of DHEA contributes to fatigue, poor concentration and diminished overall body functions.
3. Zinc
Zinc is a natural aromatase enzyme inhibitor. It helps to block the conversion of testosterone into excess estrogen. Inadequate zinc levels block the pituitary gland from releasing lutein and follicle stimulation of hormone which stimulates the production of testosterone.
4. Aromatase
Aromatase is an enzyme of the cytochrome P450 superfamily, whose function is to aromatize androgen and produce estrogen. As men age they produce greater amounts of aromatase enzymes that cause the conversion of testosterone into estrogen resulting in male hormone deficiency.
5. Liver disease
Damage to liver causes extra estrogen and sex-hormone binding globulin resulting in lower levels of testosterone.
6. Frequent sexual activity
Normal sexual activity helps to improve the yang qi in the kidney according to Chinese herbalists(that is the reason why most kings in Chinese history have some sources of sexual dysfunction). Frequent sexual activity( more than once a day and every day) will cause the depletion of yang qi resulting in low levels of testosterone, sexual dysfunction and libido in the future days.
Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Testosterone is a male hormone, besides promoting libido, it has other important functions such as maintain muscle mass and forming bone, and regulating heart muscle and cholesterol. It also helps to improve the oxygen levels throughout the body as well as controlling blood glucose and strengthening the immune system. In this article, we will discuss what causes low levels of testosterone.
As we mentioned in the other articles, human aging is the biological and pathological processes that vary from person to person and that are controllable to some degree. Starting at age 40, levels of testosterone start to diminish, the levels of the by-product prolactin of testosterone of men increases, stimulating the production of the enzyme 5-alpha reductase that causes the conversion of testosterone to gihydro-testosterones DHT thus triggering low levels of testosterone.
2. DHEA deficiency
DHEA (dehydroepiandrosterone) is a substance made by the adrenal gland. It is the precursor of the sex steroids estrogen and testosterone. DHEA has some male hormone effects and deficiency of DHEA contributes to fatigue, poor concentration and diminished overall body functions.
3. Zinc
Zinc is a natural aromatase enzyme inhibitor. It helps to block the conversion of testosterone into excess estrogen. Inadequate zinc levels block the pituitary gland from releasing lutein and follicle stimulation of hormone which stimulates the production of testosterone.
4. Aromatase
Aromatase is an enzyme of the cytochrome P450 superfamily, whose function is to aromatize androgen and produce estrogen. As men age they produce greater amounts of aromatase enzymes that cause the conversion of testosterone into estrogen resulting in male hormone deficiency.
5. Liver disease
Damage to liver causes extra estrogen and sex-hormone binding globulin resulting in lower levels of testosterone.
6. Frequent sexual activity
Normal sexual activity helps to improve the yang qi in the kidney according to Chinese herbalists(that is the reason why most kings in Chinese history have some sources of sexual dysfunction). Frequent sexual activity( more than once a day and every day) will cause the depletion of yang qi resulting in low levels of testosterone, sexual dysfunction and libido in the future days.
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Phytochemicals in Foods - The Effects of Moronic acid
Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Moronic acid
Moronic acid is a phytochemincal in the subclass of Triterpenoid, belonging to the group of Terpenes found in extracted from Rhus javanica, Mistletoe, etc.
Health Benefits
1. HIV maturation inhibitor
In the study of triterpene derivatives as potent anti-HIV agents, different C-3 conformationally restricted betulinic acid (BA, 1) derivatives were designed and synthesized in order to explore the conformational space of the C-3 pharmacophore. 3-O-Monomethylsuccinyl-betulinic acid (MSB) analogues were also designed to better understand the contribution of the C-3' dimethyl group of bevirimat (2), the first-in-class HIV maturation inhibitor, which is currently in phase IIb clinical trials. In addition, another triterpene skeleton, moronic acid (MA, 3), was also employed to study the influence of the backbone and the C-3 modification toward the anti-HIV activity of this compound class, may lead to led to the design and synthesis of compound 12 (EC(50): 0.0006 microM), which displayed slightly better activity than 2 as a HIV-1 maturation inhibitor, according to " Anti-AIDS agents 81. Design, synthesis, and structure-activity relationship study of betulinic acid and moronic acid derivatives as potent HIV maturation inhibitors" by Qian K, Kuo RY, Chen CH, Huang L, Morris-Natschke SL, Lee KH.(1)
2. Anti- Epstein-Barr virus
In the investigation of moronic acid, found in galls of Rhus chinensis and Brazilian propolis, at 10microM inhibits the expression of Rta, Zta, and an EBV early protein, EA-D, after lytic induction with sodium butyrate, found that moronic acids inhibits the capacity of Rta to activate a promoter that contains an Rta-response element, indicating that moronic acid interferes with the function of Rta. On the other hand, moronic acid does not appear to influence with the transactivation function of Zta. Therefore, the lack of expression of Zta and EA-D after moronic acid treatment is attributable to the inhibition of the transactivation functions of Rta. Because the expression of Zta, EA-D and many EBV lytic genes depends on Rta, the treatment of P3HR1 cells with moronic acid substantially reduces the numbers of EBV particles produced by the cells after lytic induction, according to "Inhibition of the Epstein-Barr virus lytic cycle by moronic acid" by Chang FR, Hsieh YC, Chang YF, Lee KH, Wu YC, Chang LK.(2)
3. Anti fungal effects
In the determination of The effect of compound isolated from ethanol extract from Xyris pteygoblephara aerial parts against five microorganism strains, by the microdilution and agar diffusion methods, indicated that assay of 1 (100 microg/disc) by the agar diffusion method against clinical isolates of the dermatophytes Epidermophyton floccosum (inhibition zone, mm+/-s.d.: 4.5+/-0.8), Trichophyton mentagrophytes (4.8+/-0.4) and Trichophyton rubrum (10.2+/-0.8) revealed similar inhibition zones to the positive control amphotericin B (32 microg/disc; 5.0+/-0.2; 5.0+/-0.6 and 8.8+/-1.2, respectively), according to "Dihydroisocoumarin from Xyris pterygoblephara active against dermatophyte fungi" by Guimarães KG, de Souza Filho JD, Dos Mares-Guia TR, Braga FC.(3)
4. Cytotoxic activity
In the isolation of the cytotoxic compound moronic acid (1) and the new tetracyclic triterpene 3,4-seco-olean-18-ene-3,28-dioic acid (2), from the aerial parts of the medicinal plant Phoradendron reichenbachianum (mistletoe, Loranthaceae) through a bioassay-guided fractionation, indicated that the structures were elucidated on the basis of chemical and spectroscopic evidence, according to "Cytotoxic activity of moronic acid and identification of the new triterpene 3,4-seco-olean-18-ene-3,28-dioic acid from Phoradendron reichenbachianum`by Rios MY, Salina D, Villarreal ML.(4)
5. Antimicrobial activity
In the isolation of the active factor C30H46O3 of the Root bark extract of the East African medicinal plant Ozoroa mucronata showed antimicrobial activity against Gram-positive bacteria, according to "Moronic acid, a simple triterpenoid keto acid with antimicrobial activity isolated from Ozoroa mucronata" by Hostettmann-Kaldas M, Nakanishi K.(5)
6. Anti-herpes simplex virus
In the study of purification two major anti-HSV compounds, moronic acid and betulonic acid, from the herbal extract by extraction with ethyl acetate at pH 10 followed by chromatographic separations and examined their anti-HSV activity in vitro and in vivo, found that Moronic acid suppressed virus yields in the brain more efficiently than those in the skin. This was consistent with the prolongation of mean survival times. Thus, moronic acid was purified as a major anti-HSV compound from the herbal extract of Rhus javanica. Mode of the anti-HSV activity was different from that of ACV, according to "Anti-herpes simplex virus activity of moronic acid purified from Rhus javanica in vitro and in vivo" by Kurokawa M, Basnet P, Ohsugi M, Hozumi T, Kadota S, Namba T, Kawana T, Shiraki K.(6)
7. Etc.
Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/20329730
(2) http://www.ncbi.nlm.nih.gov/pubmed/19969023
(3) http://www.ncbi.nlm.nih.gov/pubmed/17870137
(4) http://www.ncbi.nlm.nih.gov/pubmed/11488459
(5) https://www.thieme-connect.com/ejournals/abstract/plantamedica/doi/10.1055/s-0028-1097349
(6) http://www.ncbi.nlm.nih.gov/pubmed/10086989
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Moronic acid
Moronic acid is a phytochemincal in the subclass of Triterpenoid, belonging to the group of Terpenes found in extracted from Rhus javanica, Mistletoe, etc.
Health Benefits
1. HIV maturation inhibitor
In the study of triterpene derivatives as potent anti-HIV agents, different C-3 conformationally restricted betulinic acid (BA, 1) derivatives were designed and synthesized in order to explore the conformational space of the C-3 pharmacophore. 3-O-Monomethylsuccinyl-betulinic acid (MSB) analogues were also designed to better understand the contribution of the C-3' dimethyl group of bevirimat (2), the first-in-class HIV maturation inhibitor, which is currently in phase IIb clinical trials. In addition, another triterpene skeleton, moronic acid (MA, 3), was also employed to study the influence of the backbone and the C-3 modification toward the anti-HIV activity of this compound class, may lead to led to the design and synthesis of compound 12 (EC(50): 0.0006 microM), which displayed slightly better activity than 2 as a HIV-1 maturation inhibitor, according to " Anti-AIDS agents 81. Design, synthesis, and structure-activity relationship study of betulinic acid and moronic acid derivatives as potent HIV maturation inhibitors" by Qian K, Kuo RY, Chen CH, Huang L, Morris-Natschke SL, Lee KH.(1)
2. Anti- Epstein-Barr virus
In the investigation of moronic acid, found in galls of Rhus chinensis and Brazilian propolis, at 10microM inhibits the expression of Rta, Zta, and an EBV early protein, EA-D, after lytic induction with sodium butyrate, found that moronic acids inhibits the capacity of Rta to activate a promoter that contains an Rta-response element, indicating that moronic acid interferes with the function of Rta. On the other hand, moronic acid does not appear to influence with the transactivation function of Zta. Therefore, the lack of expression of Zta and EA-D after moronic acid treatment is attributable to the inhibition of the transactivation functions of Rta. Because the expression of Zta, EA-D and many EBV lytic genes depends on Rta, the treatment of P3HR1 cells with moronic acid substantially reduces the numbers of EBV particles produced by the cells after lytic induction, according to "Inhibition of the Epstein-Barr virus lytic cycle by moronic acid" by Chang FR, Hsieh YC, Chang YF, Lee KH, Wu YC, Chang LK.(2)
3. Anti fungal effects
In the determination of The effect of compound isolated from ethanol extract from Xyris pteygoblephara aerial parts against five microorganism strains, by the microdilution and agar diffusion methods, indicated that assay of 1 (100 microg/disc) by the agar diffusion method against clinical isolates of the dermatophytes Epidermophyton floccosum (inhibition zone, mm+/-s.d.: 4.5+/-0.8), Trichophyton mentagrophytes (4.8+/-0.4) and Trichophyton rubrum (10.2+/-0.8) revealed similar inhibition zones to the positive control amphotericin B (32 microg/disc; 5.0+/-0.2; 5.0+/-0.6 and 8.8+/-1.2, respectively), according to "Dihydroisocoumarin from Xyris pterygoblephara active against dermatophyte fungi" by Guimarães KG, de Souza Filho JD, Dos Mares-Guia TR, Braga FC.(3)
4. Cytotoxic activity
In the isolation of the cytotoxic compound moronic acid (1) and the new tetracyclic triterpene 3,4-seco-olean-18-ene-3,28-dioic acid (2), from the aerial parts of the medicinal plant Phoradendron reichenbachianum (mistletoe, Loranthaceae) through a bioassay-guided fractionation, indicated that the structures were elucidated on the basis of chemical and spectroscopic evidence, according to "Cytotoxic activity of moronic acid and identification of the new triterpene 3,4-seco-olean-18-ene-3,28-dioic acid from Phoradendron reichenbachianum`by Rios MY, Salina D, Villarreal ML.(4)
5. Antimicrobial activity
In the isolation of the active factor C30H46O3 of the Root bark extract of the East African medicinal plant Ozoroa mucronata showed antimicrobial activity against Gram-positive bacteria, according to "Moronic acid, a simple triterpenoid keto acid with antimicrobial activity isolated from Ozoroa mucronata" by Hostettmann-Kaldas M, Nakanishi K.(5)
6. Anti-herpes simplex virus
In the study of purification two major anti-HSV compounds, moronic acid and betulonic acid, from the herbal extract by extraction with ethyl acetate at pH 10 followed by chromatographic separations and examined their anti-HSV activity in vitro and in vivo, found that Moronic acid suppressed virus yields in the brain more efficiently than those in the skin. This was consistent with the prolongation of mean survival times. Thus, moronic acid was purified as a major anti-HSV compound from the herbal extract of Rhus javanica. Mode of the anti-HSV activity was different from that of ACV, according to "Anti-herpes simplex virus activity of moronic acid purified from Rhus javanica in vitro and in vivo" by Kurokawa M, Basnet P, Ohsugi M, Hozumi T, Kadota S, Namba T, Kawana T, Shiraki K.(6)
7. Etc.
Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/20329730
(2) http://www.ncbi.nlm.nih.gov/pubmed/19969023
(3) http://www.ncbi.nlm.nih.gov/pubmed/17870137
(4) http://www.ncbi.nlm.nih.gov/pubmed/11488459
(5) https://www.thieme-connect.com/ejournals/abstract/plantamedica/doi/10.1055/s-0028-1097349
(6) http://www.ncbi.nlm.nih.gov/pubmed/10086989
The #CurableSmoothie of Cooked Corn and Alfalfa and Barley tea for Treatment of Lactation Failure
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
The smoothie for prevention and treatment of Lactation failure
Yield: 2 servings (about 8 ounces each)
1 cup alfalfa and barley tea(make from 1 gram of dried affalfa and 1 gram of dried barley leaf)
1 1/2 cups cooked corn
1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately
The finding of a natural source for treatment of Malarial nephropathy has been running into many obstacles, many ingredients showed initially with promising result in animal studies have not produced same potentials in large sample size and mutli centers human trials.
Lactation failure or deficiency is a condition of not producing enough milk cause of lactation insufficient or fails completely due to insufficient glandular development of the breast. According to the Lady Hardinge Medical College, relactation is possible in most of the mothers without the help of lactagogues, through educating and motivating the mother for exclusive breastfeeding during first 4-6 months, a strong professional support by a health worker is needed to overcome the initial problems during relactation(1).
Alfalfa is a flowering plant in the genus Medicago, belonging to the family Fabaceae, It has been cultivated all over the world as hay for cattle feeding. The leaves, sprouts, and seeds to make medicine has been used in traditional medicine over thousands of year to treat high cholesterol, asthma, osteoarthritis, rheumatoid arthritis, diabetes, enhance digestive system, bleeding disorder, kidney and urinary tract infection, etc,.. In animal model, feeding alfalfa could lead to greater milk production efficiency in early lactation(3) by stimulating much greater feed intake in supported greater milk production(4).
Corn is a variety of maize with a high sugar content and prepared as a vegetable. It is a tall plant grass that has large ears with many seeds or kernels. According to the Transport and Resources, Ellinbank in diary cow study, corn grain can increase milk production even at similar metabolizable energy intakes, and that it does not matter whether these supplements are fed(5).
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
The smoothie for prevention and treatment of Lactation failure
Yield: 2 servings (about 8 ounces each)
1 cup alfalfa and barley tea(make from 1 gram of dried affalfa and 1 gram of dried barley leaf)
1 1/2 cups cooked corn
1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately
The finding of a natural source for treatment of Malarial nephropathy has been running into many obstacles, many ingredients showed initially with promising result in animal studies have not produced same potentials in large sample size and mutli centers human trials.
Lactation failure or deficiency is a condition of not producing enough milk cause of lactation insufficient or fails completely due to insufficient glandular development of the breast. According to the Lady Hardinge Medical College, relactation is possible in most of the mothers without the help of lactagogues, through educating and motivating the mother for exclusive breastfeeding during first 4-6 months, a strong professional support by a health worker is needed to overcome the initial problems during relactation(1).
Alfalfa is a flowering plant in the genus Medicago, belonging to the family Fabaceae, It has been cultivated all over the world as hay for cattle feeding. The leaves, sprouts, and seeds to make medicine has been used in traditional medicine over thousands of year to treat high cholesterol, asthma, osteoarthritis, rheumatoid arthritis, diabetes, enhance digestive system, bleeding disorder, kidney and urinary tract infection, etc,.. In animal model, feeding alfalfa could lead to greater milk production efficiency in early lactation(3) by stimulating much greater feed intake in supported greater milk production(4).
Barley, a major cereal grain is now grown in temperate climates globally for commercial profits because of its potential health effects. According to the Agriculture and Agri-Food Canada, feeding live stock with barley is associated to increase greater milk production(3).
Dr. Kargar S and colleagues at the joint study led by Isfahan University of Technology, in comparison of barley-based (BBD) or corn-based diets (CBD) found that replacing barley grain for corn grain in oil-supplemented diets did not influence feeding patterns and milk yield(6).
The smoothie of Cooked Corn and Alfalfa and Barley tea may hold a key in further studies in production of effective natural ingredients for prevention and treatment of any type of Membranous glomerulonephritis without inducing adverse effects.
Women who are at increased risk of any of Lactation failure, due to family history, obesity... should drink at least one cup daily. Women with Lactation failure, should drink no more than 4 servings daily, depending to the digestive toleration.
All Forms of Arthritis are Curable
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By addressing the Underlying Causes through Clinical Trials and Studies
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to General health http://kylejnorton.blogspot.ca/p/general-health.html
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The smoothie of Cooked Corn and Alfalfa and Barley tea may hold a key in further studies in production of effective natural ingredients for prevention and treatment of any type of Membranous glomerulonephritis without inducing adverse effects.
Women who are at increased risk of any of Lactation failure, due to family history, obesity... should drink at least one cup daily. Women with Lactation failure, should drink no more than 4 servings daily, depending to the digestive toleration.
All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to General health http://kylejnorton.blogspot.ca/p/general-health.html
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
References
(1) Relactation: an effective intervention to promote exclusive breastfeeding by Seema1, Patwari AK, Satyanarayana L.(PubMed)
(2) Lactation failure by Mathur GP1, Chitranshi S, Mathur S, Singh SB, Bhalla M.(PubMed)
(3) Improved milk production efficiency in early lactation dairy cattle with dietary addition of a developmental fibrolytic enzyme additive by Holtshausen L1, Chung YH, Gerardo-Cuervo H, Oba M, Beauchemin KA.(PubMed)
(4) Ryegrass or alfalfa silage as the dietary forage for lactating dairy cows by Broderick GA1, Koegel RG, Walgenbach RP, Kraus TJ.(PubMed)
(5) Milk production responses to different strategies for feeding supplements to grazing dairy cows by Auldist MJ1, Marett LC2, Greenwood JS2, Wright MM2, Hannah M2, Jacobs JL2, Wales WJ2.(PubMed)
(6) Reciprocal combinations of barley and corn grains in oil-supplemented diets: feeding behavior and milk yield of lactating cows by Kargar S1, Ghorbani GR2, Khorvash M2, Sadeghi-Sefidmazgi A2, Schingoethe DJ3.(PubMed)
(1) Relactation: an effective intervention to promote exclusive breastfeeding by Seema1, Patwari AK, Satyanarayana L.(PubMed)
(2) Lactation failure by Mathur GP1, Chitranshi S, Mathur S, Singh SB, Bhalla M.(PubMed)
(3) Improved milk production efficiency in early lactation dairy cattle with dietary addition of a developmental fibrolytic enzyme additive by Holtshausen L1, Chung YH, Gerardo-Cuervo H, Oba M, Beauchemin KA.(PubMed)
(4) Ryegrass or alfalfa silage as the dietary forage for lactating dairy cows by Broderick GA1, Koegel RG, Walgenbach RP, Kraus TJ.(PubMed)
(5) Milk production responses to different strategies for feeding supplements to grazing dairy cows by Auldist MJ1, Marett LC2, Greenwood JS2, Wright MM2, Hannah M2, Jacobs JL2, Wales WJ2.(PubMed)
(6) Reciprocal combinations of barley and corn grains in oil-supplemented diets: feeding behavior and milk yield of lactating cows by Kargar S1, Ghorbani GR2, Khorvash M2, Sadeghi-Sefidmazgi A2, Schingoethe DJ3.(PubMed)
The Holistic prevention, management and treatment of Polycystic Ovarian Syndrome: Top Immunity Boosting Minerals
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Polycystic Ovarian Syndrome
Polycystic Ovarian Syndrome is defined as endocrinologic diseases among reproductive-age women caused by undeveloped follicles clumping on the ovaries that interferes with the function of the normal ovaries associated with a high risk for metabolic disorder(1) as resulting of enlarged ovaries(2), leading to hormone imbalance(excessive androgen and anti-müllerian hormone (AMH) )(1)(3)(4)(5), induced Hirsutism(6)(7), reproductive disorder(10(12)), risks of type 2 diabetes(9)(10)(11), metabolic syndrome(10)(12) and early cardiovascular disease(8)(13), acne(10)(14), endometrial cancer(18)(19),weight gain and obesity(15)(16)(17). The syndrome effects over 5% of women population or 1 in 20 women.
Unfortunately, according to studies, women with PCOs after the reproductive age, are associated to continuously increase risk of type II diabetes, with no increasingaltered glucose tolerance(20), CVD and hypertension(21).
The prevention and management
Polycystic ovary syndrome (PCOS) is unpreventable in Western medicine. Early diagnosis and treatment may reduce risk of its complications, including infertility, metabolic syndrome, obesity, diabetes, cardiovascular diseases, stroke, etc.
Although PCOS cannot be completely avoided, strengthening immunity has shown a significant reduction of chronic inflammatory diseases(266)(267)(268).
The Immunity Boosting Minerals
Recent studies showed that deficiencies of zinc, iron, copper, and selenium lower resistance to disease either due to impaired immune response or faulty white blood cells' function(421)
1. Magnesium
The mineral, magnesium plays a key role in the immune response, by acting as a co-factor for immunoglobulin synthesis(422) that significantly increases for both IgA and IgG, the antibody molecules that protect our body against bacterial and viral infections(423) and the lining of the respiratory passages, gastrointestinal andgenitourinary tract(423).
The mineral also found to increase neutrophil function and enzyme peroxidase activity and reduce the incidence of health disorders by boosting immunity(424), including chronic inflammatory disease(425)(426). Low serum magnesium (Mg) is often associated with incidences of insulin resistance (IR), cardiovascular problems, diabetes mellitus, hypertension and other components of metabolic syndrome(428) in patients with polycystic ovary syndrome (PCOS)(427).
2. Selenium
Selenium, a trace mineral plays an important and indirect role as an antioxidant(429)(430) by fulfilling its function as a necessary constituent of glutathione peroxidase(431)(432) and in production of glutathione(432), that inhibits the damage caused by oxidation of free radical hydrogen peroxide(433).
Extensively epidemiological studies suggested that selenium also benefits to health aspects, including anti cancers(434)(435), lowering cholesterol(436)(438), hypertension(439)(440), treating heart disease(427)(438), boosting immunity(441)(442) against microbial invasion(443)(444) and anti chronic inflammatory disease(445)(446).
3. Zinc
Zinc besides is an important mineral in boosting immune system activity(447)(449). Its nano-structure zinc(II) coordination compounds, has been used in zinc therapy to treat candida overgrowth(449) by promoting metallothionein (MT)(found in high concentration in intestinal mucosa)synthesis(450) through its anti inflammatory activity(451), including chronic inflammation(453)(454) via immune modulatory effects(452)(453)(454).
4. Manganese
Manganese is an essential trace nutrient in all forms of life. It is well known for its role in helping the body to maintain healthy skin(455)(456) and bone structure(457)(458), but also acts as cofactors for a number of enzymes(459) in higher organisms, where they are essential in iexhibting its antioxidant effects against free radicals(450)(451). Recent studies suggested that manganese also benefits in controlling bood glucose(452)(453), alleviating neuro symptoms such as anxiety, and depression(454) and treatment of high cholesterol levels(456), hypertension(455), infertility(457), cardiomyopathy(458), reduced oxidative stress, amyloid deposition, and memory(459) and boosting immune system anti microbial infections and inflammation(460).
In larger amounts, manganese can be poisoning to neurological damage(451)(462).
5. Iron
A mineral plays a vital role for production of hemoglobin(463)(464)utilised by the body for oxygen transport and energy production(467), for maintaining healthy bones(465) and neurotransmission(466), synthesizing of some hormones and connective tissue(467)(468)(469) and maintaining heart health(470). Deficiency of iron causes low level of hemoglobin, nervous tension((473)(474)), cognitive dysfunction(471)(476), heart disorders(472)(475), heavy menstrual bleeding(479)(480), iron deficiency anemia, etc.,.. Recent studies suggested that trace mineral iron improves immunity(481)(482) fighting against microbial infection(481) and inflammatory disease(483)(484), including certain types of chronic inflammatory diseases(486)(485) due to low levels of hemoglobin impaired cell-mediated immune response and bacterial activity of leukocytes(421).
3. Copper
Copper is vital in maintaining the production of antibodies(487)(488), white blood cells(489)(490), antioxidant enzymes(491)(492), for increasing the immune function in fighting against infection(487)(488) and inflammation(493)(494), including certain chronic inflammatory diseases(495)(496). The mineral also acts as a modulator of neuronal transmission(497), regulates production of certain hormones(498). Deficiency of copper may cause metabolic liver disease(502), copper deficiency anemia(503),....Deficiency and excess of copper levels can induce infertile(499), low libido and sexual issues(500), low quality sperm production(499)(500), disrupted nervous function(501), etc.,...
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References
(1) Adiposity and metabolic dysfunction in polycystic ovary syndrome by Sam S.(PubMed)
(2) A "kiss" before conception: triggering ovulation with kisspeptin-54 may improve IVF by Young SL.(PubMed)
(3.) Androgen hyperfunction and excessive heterosexual hair growth in women, with special attention to the polycystic ovarian syndrome by Lunde O1.(PubMed)
(4) Expression of anti-Müllerian hormone in letrozole rat model of polycystic ovary syndrome by Du DF1, Li XL, Fang F, Du MR.(PubMed)
(5) [Serum levels of anti-muller hormone in women with polycystic ovary syndromeand healthy women of reproductive age].[Article in Bulgarian] by Parahuleva N, Pehlivanov B, Orbecova M, Deneva T, Uchikova E.(PubMed)
(6) [Current opinions on the etiology and pathophysiology of hirsutism].[Article in Polish] by Krysiak R1, Kedzia A, Okopień B.(PubMed)
(7) The clinical evaluation of hirsutism by Somani N1, Harrison S, Bergfeld WF.(PubMed)
(8) Polycystic ovary syndrome and insulin: our understanding in the past, present and future by Mayer SB1, Evans WS, Nestler JE.(PubMed)
(9) Association of mean platelet volume with androgens and insulin resistance in nonobese patients with polycystic ovary syndrome by Dogan BA1, Arduc A2, Tuna MM1, Karakılıc E1, Dagdelen I1, Tutuncu Y1, Berker D1, Guler S1.(PubMed)
(10) Approach to the patient: contraception in women with polycystic ovary syndrome by Yildiz BO1.(PubMed)
(11) Polycystic ovarian syndrome (PCOS): a significant contributor to the overall burden of type 2 diabetes in women by Talbott EO1, Zborowski JV, Rager JR, Kip KE, Xu X, Orchard TJ.(PubMed)
(12) Prevalence of vitamin D deficiency in Slovak women with polycystic ovary syndrome and its relation to metabolic and reproductive abnormalities by Figurová J1, Dravecká I, Javorský M, Petríková J, Lazúrová I.(PubMed)
(13) Role of Insulin Sensitizers on Cardiovascular Risk Factors in Polycystic Ovarian Syndrome: A Meta-Analysis by Thethi TK1, Katalenich B2, Nagireddy P3, Chabbra P4, Kuhadiya N5, Fonseca V1.(PubMed)
(14) Acne in hirsute women by Lumezi BG1, Pupovci HL1, Berisha VL1, Goçi AU2, Gerqari A3.(PubMed)
(15) Obesity and polycystic ovary syndrome by Naderpoor N1, Shorakae S, Joham A, Boyle J, De Courten B, Teede HJ.(PubMed)
(16) Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan by Teede H1, Deeks A, Moran L.(PubMed)
(17) Metabolic Evidence of Diminished Lipid Oxidation in Women With Polycystic Ovary Syndrome. by Whigham LD1, Butz DE2, Dashti H3, Tonelli M3, Johnson LK1, Cook ME2, Porter WP4, Eghbalnia HR5, Markley JL6, Lindheim SR7, Schoeller DA8, Abbott DH9, Assadi-Porter FM10.(PubMed)
(18) Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis by Barry JA1, Azizia MM1, Hardiman PJ2.(PubMed)
(19) Risk of cancer among women with polycystic ovary syndrome: a Danish cohort study by Gottschau M1, Kjaer SK2, Jensen A1, Munk C1, Mellemkjaer L3.(PubMed)
(20) Polycystic ovary syndrome: metabolic consequences and long-term management by Carmina E1.(PubMed)
(21) Arterial stiffness is increased in asymptomatic nondiabetic postmenopausal women with a polycystic ovary syndrome phenotype by Armeni E1, Stamatelopoulos K, Rizos D, Georgiopoulos G, Kazani M, Kazani A, Kolyviras A, Stellos K, Panoulis K, Alexandrou A, Creatsa M, Papamichael C, Lambrinoudaki I.(PubMed)
(266) [Immunopathological responses in women with chronic inflammatorydiseases of the uterus and appendages and their therapeutic correction].[Article in Russian] by Medvedev BI1, Kazachkova EA, Kazachkov EL.(PubMed)
(267) Cross Talk Between ER Stress, Oxidative Stress, and Inflammation in Health and Disease by Dandekar A1, Mendez R, Zhang K.(PubMed)
(268) New dog and new tricks: evolving roles for IL-33 in type 2 immunity by Lott JM1, Sumpter TL1, Turnquist HR2.(PubMed)
(421) Trace Minerals and ImmunologyRichard C. Bull, Professor of Animal Sciences, University of Idaho
(422) Study of possible correlation between BLOOD IMMUNOGLOBULIN G INCREASED and MAGNESIUM CITRATE(Meds fact)
(423 )In vitro antiviral and antibacterial activity of commercial intravenousimmunoglobulin preparations--a potential role for adjuvant intravenousimmunoglobulin therapy in infectious diseases by Krause I1, Wu R, Sherer Y, Patanik M, Peter JB, Shoenfeld Y.(PubMed)
(424) Effect of an injectable trace mineral supplement containing selenium, copper, zinc, and manganese on immunity, health, and growth of dairy calves by Teixeira AG1, Lima FS1, Bicalho ML1, Kussler A1, Lima SF1, Felippe MJ1, Bicalho RC2.(PubMed)
(425) Effects of magnesium depletion on inflammation in chronic disease by Nielsen FH1.(PubMed)
(426) Magnesium, inflammation, and obesity in chronic disease by Nielsen FH1.(PubMed)
(427) Serum magnesium concentrations in polycystic ovary syndrome and its association with insulin resistance by Sharifi F1, Mazloomi S, Hajihosseini R, Mazloomzadeh S.(PubMed)
(428) Serum magnesium concentrations and metabolic variables in polycystic ovary syndrome by Kauffman RP1, Tullar PE, Nipp RD, Castracane VD.(PubMed)
(429) Low zinc and selenium concentrations in sepsis are associated with oxidative damage and inflammation by Mertens K1, Lowes DA1, Webster NR1, Talib J2, Hall L2, Davies MJ3, Beattie JH4, Galley HF5.(PubMed)
(430) Serum selenium concentration and antioxidant activity in cervical cancer patients before and after treatment by Subramanyam D1, Subbaiah KV, Rajendra W, Lokanatha V.(PubMed)
(431) Selenium regulation of glutathione peroxidase in human hepatoma cell line Hep3B by Baker RD1, Baker SS, LaRosa K, Whitney C, Newburger PE.(PubMed)
(432) Selenium: biochemical role as a component of glutathione peroxidase by Rotruck JT, Pope AL, Ganther HE, Swanson AB, Hafeman DG, Hoekstra WG.(PubMed)
(433) Selenium suppressed hydrogen peroxide-induced vascular smooth muscle cells calcification through inhibiting oxidative stress and ERK activation by Liu H1, Lu Q, Huang K.(PubMed)
(434) Associations of obesity with prostate cancer risk differ between u.s. African-american and non-Hispanic white men: results from the selenium and vitamin ecancer prevention trial by Barrington WE, Schenk JM, Etzioni R, Arnold KB, Neuhouser ML, Thompson IM, Lucia MS, Kristal AR.(PubMed)
(435) Selenium for preventing cancer by Vinceti M1, Dennert G, Crespi CM, Zwahlen M, Brinkman M, Zeegers MP, Horneber M, D'Amico R, Del Giovane C.(PubMed)
(436) The association between selenium and lipid levels: a longitudinal study in rural elderly Chinese by Chen C1, Jin Y1, Unverzagt FW2, Cheng Y1, Hake AM3, Liang C1, Ma F1, Su L1, Liu J1, Bian J4, Li P5, Gao S6.(PubMed)
(437) Associations of selenium status with cardiometabolic risk factors: an 8-year follow-up analysis of the Olivetti Heart study by Stranges S1, Galletti F, Farinaro E, D'Elia L, Russo O, Iacone R, Capasso C, Carginale V, De Luca V, Della Valle E, Cappuccio FP, Strazzullo P.(PubMed)
(438) Selenium status and blood lipids: the cardiovascular risk in Young Finns study by Stranges S1, Tabák AG, Guallar E, Rayman MP, Akbaraly TN, Laclaustra M, Alfthan G, Mussalo-Rauhamaa H, Viikari JS, Raitakari OT, Kivimäki M.(PubMed)
(439) Influence of serum selenium concentrations on hypertension: the Lipid Analytic Cologne cross-sectional study by Berthold HK1, Michalke B, Krone W, Guallar E, Gouni-Berthold I(PubMed)
(440) Serum selenium concentrations and hypertension in the US Population by Laclaustra M1, Navas-Acien A, Stranges S, Ordovas JM, Guallar E.(PubMed)
(441) The role of selenium in inflammation and immunity: from molecular mechanisms to therapeutic opportunities by Huang Z1, Rose AH, Hoffmann PR.(PubMed)
(442) The influence of selenium on immune responses by Hoffmann PR1, Berry MJ.(PuMed)
(443) Selenium containing heterocycles: synthesis, anti-inflammatory, analgesic and anti-microbial activities of some new 4-cyanopyridazine-3(2H)selenone derivatives by Abdel-Hafez ShH1.(PubMed)
(444) Antimicrobial selenium nanoparticle coatings on polymeric medical devices by Tran PA1, Webster TJ.(PubMed)
(445) Selenium and selenoproteins in inflammatory bowel diseases and experimental colitis by Speckmann B1, Steinbrenner H.(PubMed)
(446) Selenium, selenoproteins and human health: a review by Brown KM1, Arthur JR.(PubMed)
(447) Zinc and the immune system by Rink L1, Gabriel P.(PubMed)
(448) The immune system and the impact of zinc during aging by Haase H1, Rink L.(PubMed)
(449) Some new nano-structure zinc(II) coordination compounds of an imidazolidine Schiff base: spectral, thermal, antimicrobial properties and DNA interaction. Montazerozohori M1, Musavi SA2, Naghiha A3, Zohour MM4.(PubMed)
(450) Candida article zinc and metallothionein(Cure zone)
(451) Metallothionein as an Anti-Inflammatory Mediator(Mediators of inflammation)
(452) Zinc and its role in immunity and inflammation by Bonaventura P1, Benedetti G1, Albarède F2, Miossec P3.(PubMed)
(453) Zinc: role in immunity, oxidative stress and chronic inflammation by Prasad AS1(PubMed)
(454) Zinc transporter SLC39A10/ZIP10 controls humoral immunity by modulating B-cell receptor signal strength by Hojyo S1, Miyai T2, Fujishiro H3, Kawamura M4, Yasuda T5, Hijikata A6, Bin BH7, Irié T8, Tanaka J8, Atsumi T9, Murakami M9, Nakayama M10, Ohara O11, Himeno S3, Yoshida H5, Koseki H12, Ikawa T13, Mishima K8, Fukada T14(PubMed)
(455) Frequency of autoallergy to manganese superoxide dismutase in atopic dermatitis patients: experience of three Italian dermatology centers by Guarneri F1, Costa C, Foti C, Hansel K, Guarneri C, Guarneri B, Lisi P, Stingeni L.(PubMed)
(456) IgE-mediated and T cell-mediated autoimmunity against manganesesuperoxide dismutase in atopic dermatitis by Schmid-Grendelmeier P1, Flückiger S, Disch R, Trautmann A, Wüthrich B, Blaser K, Scheynius A, Crameri R.(PubMed)
(457) Manganese accumulation in bone following chronic exposure in rats: steady-state concentration and half-life in bone by O'Neal SL1, Hong L1, Fu S1, Jiang W1, Jones A1, Nie LH1, Zheng W2.(PubMed)
(458) A compact DD neutron generator-based NAA system to quantify manganese(Mn) in bone in vivo by Liu Y1, Byrne P, Wang H, Koltick D, Zheng W, Nie LH.(PubMed)
(459) Role of metal cofactors in enzyme regulation. Differences in the regulatory properties of the Escherichia coli nicotinamide adenine dinucleotide phosphate specific malic enzyme, depending on whether magnesium ion or manganese ion serves as divalent cation by Brown DA, Cook RA.(PubMed)
(450) Antioxidants and NOS inhibitors selectively targets manganese-induced cell volume via Na-K-Cl cotransporter-1 in astrocytes by Alahmari KA1, Harini P2, Prabhakaran K3, Chandramoorthy HC4, Ramakrishnan R5.(PubMed)
(451) Antioxidant effect of manganese by Coassin M1, Ursini F, Bindoli A.(PubMed)
(452) Manganese supplementation protects against diet-induced diabetes in wild type mice by enhancing insulin secretion by Lee SH1, Jouihan HA, Cooksey RC, Jones D, Kim HJ, Winge DR, McClain DA.(PubMed)
(453) Manganese-Mediated MRI Signals Correlate With Functional β-Cell Mass During Diabetes Progression by Meyer A1, Stolz K1, Dreher W2, Bergemann J1, Holebasavanahalli Thimmashetty V2, Lueschen N1, Azizi Z1, Khobragade V1, Maedler K3, Kuestermann E2.(PubMed)
(454) Essential elements in depression and anxiety. Part II by Młyniec K1, Gaweł M2, Doboszewska U3, Starowicz G4, Pytka K5, Davies CL6, Budziszewska B7.(PubMed)
(455) Effect of antioxidant mineral elements supplementation in the treatment of hypertension in albino rats by Muhammad SA1, Bilbis LS, Saidu Y, Adamu Y.(PubMed)
(456) Manganese supplementation reduces the blood cholesterol levels in Ca-deficient ovariectomized rats by Bae YJ1, Choi MK, Kim MH.(PubMed)
(457) BOVINE INFERTILITY--RESPONSE TO MANGANESE THERAPY by WILSON JG.(PubMed)
(458)Pharmaceutical effect of manganese porphyrins on manganese superoxide dismutase deficient mice by Hayakawa N1, Asayama S, Noda Y, Shimizu T, Kawakami H.(PubMed)
(459) Reduction of oxidative stress, amyloid deposition, and memory deficit bymanganese superoxide dismutase overexpression in a transgenic mouse model of Alzheimer's disease by Dumont M1, Wille E, Stack C, Calingasan NY, Beal MF, Lin MT.(PubMed)
(460) Nutritional immunity beyond iron: a role for manganese and zinc by Kehl-Fie TE1, Skaar EP.(PubMed)
(461) Genetic factors and manganese-induced neurotoxicity. by Chen P1, Parmalee N1, Aschner M1.(PubMed)
(462) Manganese neurotoxicity: a focus on glutamate transporters by Karki P, Lee E, Aschner M1.(PubMed)
(463) HEMOGLOBIN PRODUCTION IN ANEMIA LIMITED BY LOW PROTEIN INTAKE : INFLUENCE OF IRON INTAKE, PROTEIN SUPPLEMENTS AND FASTING by Hahn PF1, Whipple GH.(PubMed)
(464) Effect of iron deficiency anemia on the levels of hemoglobin A1c in nondiabetic patients by Coban E1, Ozdogan M, Timuragaoglu A.(PubMed)
(465) Low serum levels of zinc, copper, and iron as risk factors for osteoporosis: a meta-analysis by Zheng J1, Mao X, Ling J, He Q, Quan J.(PubMed)
(466) Brain iron deficiency and excess; cognitive impairment and neurodegeneration with involvement of striatum and hippocampus by Youdim MB1.(PubMed)
(467) Athletic induced iron deficiency: new insights into the role of inflammation, cytokines and hormones by Peeling P1, Dawson B, Goodman C, Landers G, Trinder D.(PubMed)
(468) Aggett PJ. Iron. In: Erdman JW, Macdonald IA, Zeisel SH, eds. Present Knowledge in Nutrition. 10th ed. Washington, DC: Wiley-Blackwell; 2012:506-20.
(469) Murray-Kolbe LE, Beard J. Iron. In: Coates PM, Betz JM, Blackman MR, et al., eds. Encyclopedia of Dietary Supplements. 2nd ed. London and New York: Informa Healthcare; 2010:432-8.
(470) Cardiac ferroportin regulates cellular iron homeostasis and is important for cardiac function by Lakhal-Littleton S1, Wolna M2, Carr CA2, Miller JJ2, Christian HC2, Ball V2, Santos A3, Diaz R3, Biggs D3, Stillion R4, Holdship P5, Larner F5, Tyler DJ2, Clarke K2, Davies B3, Robbins PA2.(PubMed)
(471) Effect of dietary iron loading on recognition memory in growing rats by Han M1, Kim J1.(PubMed)
(472) [Anaemia and iron deficiency in clinical practice:from cardiology to gastroenterology and beyond].
[Article in Czech] by Češka R.(PubMed)
(473) Iron and mechanisms of emotional behavior by Kim J1, Wessling-Resnick M2.(PubMed)
(474) Essential elements in depression and anxiety. Part I by Młyniec K1, Davies CL2, de Agüero Sánchez IG3, Pytka K4, Budziszewska B5, Nowak G6.(PubMed)
(475) Iron deficiency: an emerging therapeutic target in heart failure by Cohen-Solal A1, Leclercq C2, Deray G3, Lasocki S4, Zambrowski JJ5, Mebazaa A6, de Groote P7, Damy T8, Galinier M9.(PubMed)
(476) Effect of iron-deficiency anemia on cognitive skills and neuromaturation in infancy and childhood by Walter T1.(PubMed)
(479) Effects of anemia and iron deficiency on quality of life in women with heavy menstrual bleeding by Peuranpää P1, Heliövaara-Peippo S, Fraser I, Paavonen J, Hurskainen R.(PubMed)
(480) Iron deficiency and fatigue in adolescent females with heavy menstrual bleeding by Wang W1, Bourgeois T, Klima J, Berlan ED, Fischer AN, O'Brien SH.(PubMed)
(481) Iron at the interface of immunity and infection by Nairz M1, Haschka D1, Demetz E1, Weiss G1.(PubMed)
(482) Impact of iron deficiency anemia on cell-mediated and humoral immunity in children: A case control study by Das I1, Saha K1, Mukhopadhyay D2, Roy S1, Raychaudhuri G3, Chatterjee M2, Mitra PK1.(PubMed)
(483) Iron Supplementation Attenuates the Inflammatory Status of Anemic Piglets by Regulating Hepcidin by Pu Y1, Guo B, Liu D, Xiong H, Wang Y, Du H.(PubMed)
(484) A novel inflammatory pathway mediating rapid hepcidin-independent hypoferremia by Guida C1, Altamura S2, Klein FA3, Galy B3, Boutros M4, Ulmer AJ5, Hentze MW6, Muckenthaler MU2.(PubMed)
(485) Prediction of iron deficiency in chronic inflammatory rheumatic diseaseanaemia by Baumann Kurer S1, Seifert B, Michel B, Ruegg R, Fehr J.(PubMed)
(486) Changes in Echocardiographic Parameters in Iron Deficiency Patients with Heart Failure and Chronic Kidney Disease Treated with Intravenous Iron by Toblli JE1, Di Gennaro F2, Rivas C2.(PubMed)
(487) Antimicrobial copper's potential.[No authors listed](PubMed)
(488) Effects of in-feed copper and tylosin supplementations on copper andantimicrobial resistance in fecal enterococci of feedlot cattle by Amachawadi RG1, Scott HM, Aperce C, Vinasco J, Drouillard JS, Nagaraja TG.(PubMed)
(489) Copper and immunity by Percival SS1.(PubMed)
(490) The immune system as a physiological indicator of marginal copper status? by Bonham M1, O'Connor JM, Hannigan BM, Strain JJ.(PubMed)
(491) Molecular basis for antioxidant enzymes in mediating copper detoxification in the nematode Caenorhabditis elegans by Song S1, Zhang X1, Wu H1, Han Y2, Zhang J1, Ma E1, Guo Y2.(PubMed)
(492) The effects of coadministration of dietary copper and zinc supplements on atherosclerosis, antioxidant enzymes and indices of lipid peroxidation in the cholesterol-fed rabbit by Alissa EM1, Bahijri SM, Lamb DJ, Ferns GA.(PubMed)
(493) Is copper pro- or anti-inflammatory? A reconciling view and a novel approach for the use of copper in the control of inflammation by Berthon G1(PubMed)
(494) Effect of a topical copper indomethacin gel on inflammatory parameters in a rat model of osteoarthritis by Yassin NZ1, El-Shenawy SM1, Abdel-Rahman RF1, Yakoot M2, Hassan M3, Helmy S4.(PubMed)
(495) Enhanced analgesic properties and reduced ulcerogenic effect of a mononuclear copper(II) complex with fenoprofen in comparison to the parent drug: promising insights in the treatment of chronic inflammatory diseases by Agotegaray M1, Gumilar F2, Boeris M3, Toso R3, Minetti A2.(PubMed)
(496) Nutraceuticals of anti-inflammatory activity as complementary therapy for rheumatoid arthritis by Al-Okbi SY1.(PubMed)
(497) Copper homeostasis in the CNS: a novel link between the NMDA receptor and copper homeostasis in the hippocampus by Schlief ML1, Gitlin JD.(PubMed)
(498) Effect of sex hormones on copper, zinc, iron nutritional status and hepatic lipid peroxidation in rats by Wachnik A1, Biró G, Biró L, Korom M, Gergely A, Antal M.(PubMed)
(499) Copper-zinc superoxide dismutase deficiency impairs sperm motility and in vivo fertility by Garratt M1, Bathgate R, de Graaf SP, Brooks RC.(PubMed)
(500) Iron and copper in male reproduction: a double-edged sword by Tvrda E1, Peer R, Sikka SC, Agarwal A.(PubMed)
(501) Interactions of peptide amidation and copper: novel biomarkers and mechanisms of neural dysfunction by Bousquet-Moore D1, Prohaska JR, Nillni EA, Czyzyk T, Wetsel WC, Mains RE, Eipper BA.(PubMed)
(502) Deficient copper concentrations in dried-defatted hepatic tissue from ob/ob mice: A potential model for study of defective copper regulation in metabolic liver disease by Church SJ1, Begley P1, Kureishy N1, McHarg S1, Bishop PN1, Bechtold DA2, Unwin RD3, Cooper GJ4.(PubMed)
(503) Update on anemia and neutropenia in copper deficiency by Lazarchick J1.(PubMed)
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Polycystic Ovarian Syndrome
Unfortunately, according to studies, women with PCOs after the reproductive age, are associated to continuously increase risk of type II diabetes, with no increasingaltered glucose tolerance(20), CVD and hypertension(21).
The prevention and management
Polycystic ovary syndrome (PCOS) is unpreventable in Western medicine. Early diagnosis and treatment may reduce risk of its complications, including infertility, metabolic syndrome, obesity, diabetes, cardiovascular diseases, stroke, etc.
Although PCOS cannot be completely avoided, strengthening immunity has shown a significant reduction of chronic inflammatory diseases(266)(267)(268).
The Immunity Boosting Minerals
Recent studies showed that deficiencies of zinc, iron, copper, and selenium lower resistance to disease either due to impaired immune response or faulty white blood cells' function(421)
1. Magnesium
The mineral, magnesium plays a key role in the immune response, by acting as a co-factor for immunoglobulin synthesis(422) that significantly increases for both IgA and IgG, the antibody molecules that protect our body against bacterial and viral infections(423) and the lining of the respiratory passages, gastrointestinal andgenitourinary tract(423).
The mineral also found to increase neutrophil function and enzyme peroxidase activity and reduce the incidence of health disorders by boosting immunity(424), including chronic inflammatory disease(425)(426). Low serum magnesium (Mg) is often associated with incidences of insulin resistance (IR), cardiovascular problems, diabetes mellitus, hypertension and other components of metabolic syndrome(428) in patients with polycystic ovary syndrome (PCOS)(427).
2. Selenium
Selenium, a trace mineral plays an important and indirect role as an antioxidant(429)(430) by fulfilling its function as a necessary constituent of glutathione peroxidase(431)(432) and in production of glutathione(432), that inhibits the damage caused by oxidation of free radical hydrogen peroxide(433).
Extensively epidemiological studies suggested that selenium also benefits to health aspects, including anti cancers(434)(435), lowering cholesterol(436)(438), hypertension(439)(440), treating heart disease(427)(438), boosting immunity(441)(442) against microbial invasion(443)(444) and anti chronic inflammatory disease(445)(446).
3. Zinc
Zinc besides is an important mineral in boosting immune system activity(447)(449). Its nano-structure zinc(II) coordination compounds, has been used in zinc therapy to treat candida overgrowth(449) by promoting metallothionein (MT)(found in high concentration in intestinal mucosa)synthesis(450) through its anti inflammatory activity(451), including chronic inflammation(453)(454) via immune modulatory effects(452)(453)(454).
4. Manganese
Manganese is an essential trace nutrient in all forms of life. It is well known for its role in helping the body to maintain healthy skin(455)(456) and bone structure(457)(458), but also acts as cofactors for a number of enzymes(459) in higher organisms, where they are essential in iexhibting its antioxidant effects against free radicals(450)(451). Recent studies suggested that manganese also benefits in controlling bood glucose(452)(453), alleviating neuro symptoms such as anxiety, and depression(454) and treatment of high cholesterol levels(456), hypertension(455), infertility(457), cardiomyopathy(458), reduced oxidative stress, amyloid deposition, and memory(459) and boosting immune system anti microbial infections and inflammation(460).
In larger amounts, manganese can be poisoning to neurological damage(451)(462).
5. Iron
A mineral plays a vital role for production of hemoglobin(463)(464)utilised by the body for oxygen transport and energy production(467), for maintaining healthy bones(465) and neurotransmission(466), synthesizing of some hormones and connective tissue(467)(468)(469) and maintaining heart health(470). Deficiency of iron causes low level of hemoglobin, nervous tension((473)(474)), cognitive dysfunction(471)(476), heart disorders(472)(475), heavy menstrual bleeding(479)(480), iron deficiency anemia, etc.,.. Recent studies suggested that trace mineral iron improves immunity(481)(482) fighting against microbial infection(481) and inflammatory disease(483)(484), including certain types of chronic inflammatory diseases(486)(485) due to low levels of hemoglobin impaired cell-mediated immune response and bacterial activity of leukocytes(421).
3. Copper
Copper is vital in maintaining the production of antibodies(487)(488), white blood cells(489)(490), antioxidant enzymes(491)(492), for increasing the immune function in fighting against infection(487)(488) and inflammation(493)(494), including certain chronic inflammatory diseases(495)(496). The mineral also acts as a modulator of neuronal transmission(497), regulates production of certain hormones(498). Deficiency of copper may cause metabolic liver disease(502), copper deficiency anemia(503),....Deficiency and excess of copper levels can induce infertile(499), low libido and sexual issues(500), low quality sperm production(499)(500), disrupted nervous function(501), etc.,...
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References
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(2) A "kiss" before conception: triggering ovulation with kisspeptin-54 may improve IVF by Young SL.(PubMed)
(3.) Androgen hyperfunction and excessive heterosexual hair growth in women, with special attention to the polycystic ovarian syndrome by Lunde O1.(PubMed)
(4) Expression of anti-Müllerian hormone in letrozole rat model of polycystic ovary syndrome by Du DF1, Li XL, Fang F, Du MR.(PubMed)
(5) [Serum levels of anti-muller hormone in women with polycystic ovary syndromeand healthy women of reproductive age].[Article in Bulgarian] by Parahuleva N, Pehlivanov B, Orbecova M, Deneva T, Uchikova E.(PubMed)
(6) [Current opinions on the etiology and pathophysiology of hirsutism].[Article in Polish] by Krysiak R1, Kedzia A, Okopień B.(PubMed)
(7) The clinical evaluation of hirsutism by Somani N1, Harrison S, Bergfeld WF.(PubMed)
(8) Polycystic ovary syndrome and insulin: our understanding in the past, present and future by Mayer SB1, Evans WS, Nestler JE.(PubMed)
(9) Association of mean platelet volume with androgens and insulin resistance in nonobese patients with polycystic ovary syndrome by Dogan BA1, Arduc A2, Tuna MM1, Karakılıc E1, Dagdelen I1, Tutuncu Y1, Berker D1, Guler S1.(PubMed)
(10) Approach to the patient: contraception in women with polycystic ovary syndrome by Yildiz BO1.(PubMed)
(11) Polycystic ovarian syndrome (PCOS): a significant contributor to the overall burden of type 2 diabetes in women by Talbott EO1, Zborowski JV, Rager JR, Kip KE, Xu X, Orchard TJ.(PubMed)
(12) Prevalence of vitamin D deficiency in Slovak women with polycystic ovary syndrome and its relation to metabolic and reproductive abnormalities by Figurová J1, Dravecká I, Javorský M, Petríková J, Lazúrová I.(PubMed)
(13) Role of Insulin Sensitizers on Cardiovascular Risk Factors in Polycystic Ovarian Syndrome: A Meta-Analysis by Thethi TK1, Katalenich B2, Nagireddy P3, Chabbra P4, Kuhadiya N5, Fonseca V1.(PubMed)
(14) Acne in hirsute women by Lumezi BG1, Pupovci HL1, Berisha VL1, Goçi AU2, Gerqari A3.(PubMed)
(15) Obesity and polycystic ovary syndrome by Naderpoor N1, Shorakae S, Joham A, Boyle J, De Courten B, Teede HJ.(PubMed)
(16) Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan by Teede H1, Deeks A, Moran L.(PubMed)
(17) Metabolic Evidence of Diminished Lipid Oxidation in Women With Polycystic Ovary Syndrome. by Whigham LD1, Butz DE2, Dashti H3, Tonelli M3, Johnson LK1, Cook ME2, Porter WP4, Eghbalnia HR5, Markley JL6, Lindheim SR7, Schoeller DA8, Abbott DH9, Assadi-Porter FM10.(PubMed)
(18) Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis by Barry JA1, Azizia MM1, Hardiman PJ2.(PubMed)
(19) Risk of cancer among women with polycystic ovary syndrome: a Danish cohort study by Gottschau M1, Kjaer SK2, Jensen A1, Munk C1, Mellemkjaer L3.(PubMed)
(20) Polycystic ovary syndrome: metabolic consequences and long-term management by Carmina E1.(PubMed)
(21) Arterial stiffness is increased in asymptomatic nondiabetic postmenopausal women with a polycystic ovary syndrome phenotype by Armeni E1, Stamatelopoulos K, Rizos D, Georgiopoulos G, Kazani M, Kazani A, Kolyviras A, Stellos K, Panoulis K, Alexandrou A, Creatsa M, Papamichael C, Lambrinoudaki I.(PubMed)
(266) [Immunopathological responses in women with chronic inflammatorydiseases of the uterus and appendages and their therapeutic correction].[Article in Russian] by Medvedev BI1, Kazachkova EA, Kazachkov EL.(PubMed)
(267) Cross Talk Between ER Stress, Oxidative Stress, and Inflammation in Health and Disease by Dandekar A1, Mendez R, Zhang K.(PubMed)
(268) New dog and new tricks: evolving roles for IL-33 in type 2 immunity by Lott JM1, Sumpter TL1, Turnquist HR2.(PubMed)
(421) Trace Minerals and ImmunologyRichard C. Bull, Professor of Animal Sciences, University of Idaho
(422) Study of possible correlation between BLOOD IMMUNOGLOBULIN G INCREASED and MAGNESIUM CITRATE(Meds fact)
(423 )In vitro antiviral and antibacterial activity of commercial intravenousimmunoglobulin preparations--a potential role for adjuvant intravenousimmunoglobulin therapy in infectious diseases by Krause I1, Wu R, Sherer Y, Patanik M, Peter JB, Shoenfeld Y.(PubMed)
(424) Effect of an injectable trace mineral supplement containing selenium, copper, zinc, and manganese on immunity, health, and growth of dairy calves by Teixeira AG1, Lima FS1, Bicalho ML1, Kussler A1, Lima SF1, Felippe MJ1, Bicalho RC2.(PubMed)
(425) Effects of magnesium depletion on inflammation in chronic disease by Nielsen FH1.(PubMed)
(426) Magnesium, inflammation, and obesity in chronic disease by Nielsen FH1.(PubMed)
(427) Serum magnesium concentrations in polycystic ovary syndrome and its association with insulin resistance by Sharifi F1, Mazloomi S, Hajihosseini R, Mazloomzadeh S.(PubMed)
(428) Serum magnesium concentrations and metabolic variables in polycystic ovary syndrome by Kauffman RP1, Tullar PE, Nipp RD, Castracane VD.(PubMed)
(429) Low zinc and selenium concentrations in sepsis are associated with oxidative damage and inflammation by Mertens K1, Lowes DA1, Webster NR1, Talib J2, Hall L2, Davies MJ3, Beattie JH4, Galley HF5.(PubMed)
(430) Serum selenium concentration and antioxidant activity in cervical cancer patients before and after treatment by Subramanyam D1, Subbaiah KV, Rajendra W, Lokanatha V.(PubMed)
(431) Selenium regulation of glutathione peroxidase in human hepatoma cell line Hep3B by Baker RD1, Baker SS, LaRosa K, Whitney C, Newburger PE.(PubMed)
(432) Selenium: biochemical role as a component of glutathione peroxidase by Rotruck JT, Pope AL, Ganther HE, Swanson AB, Hafeman DG, Hoekstra WG.(PubMed)
(433) Selenium suppressed hydrogen peroxide-induced vascular smooth muscle cells calcification through inhibiting oxidative stress and ERK activation by Liu H1, Lu Q, Huang K.(PubMed)
(434) Associations of obesity with prostate cancer risk differ between u.s. African-american and non-Hispanic white men: results from the selenium and vitamin ecancer prevention trial by Barrington WE, Schenk JM, Etzioni R, Arnold KB, Neuhouser ML, Thompson IM, Lucia MS, Kristal AR.(PubMed)
(435) Selenium for preventing cancer by Vinceti M1, Dennert G, Crespi CM, Zwahlen M, Brinkman M, Zeegers MP, Horneber M, D'Amico R, Del Giovane C.(PubMed)
(436) The association between selenium and lipid levels: a longitudinal study in rural elderly Chinese by Chen C1, Jin Y1, Unverzagt FW2, Cheng Y1, Hake AM3, Liang C1, Ma F1, Su L1, Liu J1, Bian J4, Li P5, Gao S6.(PubMed)
(437) Associations of selenium status with cardiometabolic risk factors: an 8-year follow-up analysis of the Olivetti Heart study by Stranges S1, Galletti F, Farinaro E, D'Elia L, Russo O, Iacone R, Capasso C, Carginale V, De Luca V, Della Valle E, Cappuccio FP, Strazzullo P.(PubMed)
(438) Selenium status and blood lipids: the cardiovascular risk in Young Finns study by Stranges S1, Tabák AG, Guallar E, Rayman MP, Akbaraly TN, Laclaustra M, Alfthan G, Mussalo-Rauhamaa H, Viikari JS, Raitakari OT, Kivimäki M.(PubMed)
(439) Influence of serum selenium concentrations on hypertension: the Lipid Analytic Cologne cross-sectional study by Berthold HK1, Michalke B, Krone W, Guallar E, Gouni-Berthold I(PubMed)
(440) Serum selenium concentrations and hypertension in the US Population by Laclaustra M1, Navas-Acien A, Stranges S, Ordovas JM, Guallar E.(PubMed)
(441) The role of selenium in inflammation and immunity: from molecular mechanisms to therapeutic opportunities by Huang Z1, Rose AH, Hoffmann PR.(PubMed)
(442) The influence of selenium on immune responses by Hoffmann PR1, Berry MJ.(PuMed)
(443) Selenium containing heterocycles: synthesis, anti-inflammatory, analgesic and anti-microbial activities of some new 4-cyanopyridazine-3(2H)selenone derivatives by Abdel-Hafez ShH1.(PubMed)
(444) Antimicrobial selenium nanoparticle coatings on polymeric medical devices by Tran PA1, Webster TJ.(PubMed)
(445) Selenium and selenoproteins in inflammatory bowel diseases and experimental colitis by Speckmann B1, Steinbrenner H.(PubMed)
(446) Selenium, selenoproteins and human health: a review by Brown KM1, Arthur JR.(PubMed)
(447) Zinc and the immune system by Rink L1, Gabriel P.(PubMed)
(448) The immune system and the impact of zinc during aging by Haase H1, Rink L.(PubMed)
(449) Some new nano-structure zinc(II) coordination compounds of an imidazolidine Schiff base: spectral, thermal, antimicrobial properties and DNA interaction. Montazerozohori M1, Musavi SA2, Naghiha A3, Zohour MM4.(PubMed)
(450) Candida article zinc and metallothionein(Cure zone)
(451) Metallothionein as an Anti-Inflammatory Mediator(Mediators of inflammation)
(452) Zinc and its role in immunity and inflammation by Bonaventura P1, Benedetti G1, Albarède F2, Miossec P3.(PubMed)
(453) Zinc: role in immunity, oxidative stress and chronic inflammation by Prasad AS1(PubMed)
(454) Zinc transporter SLC39A10/ZIP10 controls humoral immunity by modulating B-cell receptor signal strength by Hojyo S1, Miyai T2, Fujishiro H3, Kawamura M4, Yasuda T5, Hijikata A6, Bin BH7, Irié T8, Tanaka J8, Atsumi T9, Murakami M9, Nakayama M10, Ohara O11, Himeno S3, Yoshida H5, Koseki H12, Ikawa T13, Mishima K8, Fukada T14(PubMed)
(455) Frequency of autoallergy to manganese superoxide dismutase in atopic dermatitis patients: experience of three Italian dermatology centers by Guarneri F1, Costa C, Foti C, Hansel K, Guarneri C, Guarneri B, Lisi P, Stingeni L.(PubMed)
(456) IgE-mediated and T cell-mediated autoimmunity against manganesesuperoxide dismutase in atopic dermatitis by Schmid-Grendelmeier P1, Flückiger S, Disch R, Trautmann A, Wüthrich B, Blaser K, Scheynius A, Crameri R.(PubMed)
(457) Manganese accumulation in bone following chronic exposure in rats: steady-state concentration and half-life in bone by O'Neal SL1, Hong L1, Fu S1, Jiang W1, Jones A1, Nie LH1, Zheng W2.(PubMed)
(458) A compact DD neutron generator-based NAA system to quantify manganese(Mn) in bone in vivo by Liu Y1, Byrne P, Wang H, Koltick D, Zheng W, Nie LH.(PubMed)
(459) Role of metal cofactors in enzyme regulation. Differences in the regulatory properties of the Escherichia coli nicotinamide adenine dinucleotide phosphate specific malic enzyme, depending on whether magnesium ion or manganese ion serves as divalent cation by Brown DA, Cook RA.(PubMed)
(450) Antioxidants and NOS inhibitors selectively targets manganese-induced cell volume via Na-K-Cl cotransporter-1 in astrocytes by Alahmari KA1, Harini P2, Prabhakaran K3, Chandramoorthy HC4, Ramakrishnan R5.(PubMed)
(451) Antioxidant effect of manganese by Coassin M1, Ursini F, Bindoli A.(PubMed)
(452) Manganese supplementation protects against diet-induced diabetes in wild type mice by enhancing insulin secretion by Lee SH1, Jouihan HA, Cooksey RC, Jones D, Kim HJ, Winge DR, McClain DA.(PubMed)
(453) Manganese-Mediated MRI Signals Correlate With Functional β-Cell Mass During Diabetes Progression by Meyer A1, Stolz K1, Dreher W2, Bergemann J1, Holebasavanahalli Thimmashetty V2, Lueschen N1, Azizi Z1, Khobragade V1, Maedler K3, Kuestermann E2.(PubMed)
(454) Essential elements in depression and anxiety. Part II by Młyniec K1, Gaweł M2, Doboszewska U3, Starowicz G4, Pytka K5, Davies CL6, Budziszewska B7.(PubMed)
(455) Effect of antioxidant mineral elements supplementation in the treatment of hypertension in albino rats by Muhammad SA1, Bilbis LS, Saidu Y, Adamu Y.(PubMed)
(456) Manganese supplementation reduces the blood cholesterol levels in Ca-deficient ovariectomized rats by Bae YJ1, Choi MK, Kim MH.(PubMed)
(457) BOVINE INFERTILITY--RESPONSE TO MANGANESE THERAPY by WILSON JG.(PubMed)
(458)Pharmaceutical effect of manganese porphyrins on manganese superoxide dismutase deficient mice by Hayakawa N1, Asayama S, Noda Y, Shimizu T, Kawakami H.(PubMed)
(459) Reduction of oxidative stress, amyloid deposition, and memory deficit bymanganese superoxide dismutase overexpression in a transgenic mouse model of Alzheimer's disease by Dumont M1, Wille E, Stack C, Calingasan NY, Beal MF, Lin MT.(PubMed)
(460) Nutritional immunity beyond iron: a role for manganese and zinc by Kehl-Fie TE1, Skaar EP.(PubMed)
(461) Genetic factors and manganese-induced neurotoxicity. by Chen P1, Parmalee N1, Aschner M1.(PubMed)
(462) Manganese neurotoxicity: a focus on glutamate transporters by Karki P, Lee E, Aschner M1.(PubMed)
(463) HEMOGLOBIN PRODUCTION IN ANEMIA LIMITED BY LOW PROTEIN INTAKE : INFLUENCE OF IRON INTAKE, PROTEIN SUPPLEMENTS AND FASTING by Hahn PF1, Whipple GH.(PubMed)
(464) Effect of iron deficiency anemia on the levels of hemoglobin A1c in nondiabetic patients by Coban E1, Ozdogan M, Timuragaoglu A.(PubMed)
(465) Low serum levels of zinc, copper, and iron as risk factors for osteoporosis: a meta-analysis by Zheng J1, Mao X, Ling J, He Q, Quan J.(PubMed)
(466) Brain iron deficiency and excess; cognitive impairment and neurodegeneration with involvement of striatum and hippocampus by Youdim MB1.(PubMed)
(467) Athletic induced iron deficiency: new insights into the role of inflammation, cytokines and hormones by Peeling P1, Dawson B, Goodman C, Landers G, Trinder D.(PubMed)
(468) Aggett PJ. Iron. In: Erdman JW, Macdonald IA, Zeisel SH, eds. Present Knowledge in Nutrition. 10th ed. Washington, DC: Wiley-Blackwell; 2012:506-20.
(469) Murray-Kolbe LE, Beard J. Iron. In: Coates PM, Betz JM, Blackman MR, et al., eds. Encyclopedia of Dietary Supplements. 2nd ed. London and New York: Informa Healthcare; 2010:432-8.
(470) Cardiac ferroportin regulates cellular iron homeostasis and is important for cardiac function by Lakhal-Littleton S1, Wolna M2, Carr CA2, Miller JJ2, Christian HC2, Ball V2, Santos A3, Diaz R3, Biggs D3, Stillion R4, Holdship P5, Larner F5, Tyler DJ2, Clarke K2, Davies B3, Robbins PA2.(PubMed)
(471) Effect of dietary iron loading on recognition memory in growing rats by Han M1, Kim J1.(PubMed)
(472) [Anaemia and iron deficiency in clinical practice:from cardiology to gastroenterology and beyond].
[Article in Czech] by Češka R.(PubMed)
(473) Iron and mechanisms of emotional behavior by Kim J1, Wessling-Resnick M2.(PubMed)
(474) Essential elements in depression and anxiety. Part I by Młyniec K1, Davies CL2, de Agüero Sánchez IG3, Pytka K4, Budziszewska B5, Nowak G6.(PubMed)
(475) Iron deficiency: an emerging therapeutic target in heart failure by Cohen-Solal A1, Leclercq C2, Deray G3, Lasocki S4, Zambrowski JJ5, Mebazaa A6, de Groote P7, Damy T8, Galinier M9.(PubMed)
(476) Effect of iron-deficiency anemia on cognitive skills and neuromaturation in infancy and childhood by Walter T1.(PubMed)
(479) Effects of anemia and iron deficiency on quality of life in women with heavy menstrual bleeding by Peuranpää P1, Heliövaara-Peippo S, Fraser I, Paavonen J, Hurskainen R.(PubMed)
(480) Iron deficiency and fatigue in adolescent females with heavy menstrual bleeding by Wang W1, Bourgeois T, Klima J, Berlan ED, Fischer AN, O'Brien SH.(PubMed)
(481) Iron at the interface of immunity and infection by Nairz M1, Haschka D1, Demetz E1, Weiss G1.(PubMed)
(482) Impact of iron deficiency anemia on cell-mediated and humoral immunity in children: A case control study by Das I1, Saha K1, Mukhopadhyay D2, Roy S1, Raychaudhuri G3, Chatterjee M2, Mitra PK1.(PubMed)
(483) Iron Supplementation Attenuates the Inflammatory Status of Anemic Piglets by Regulating Hepcidin by Pu Y1, Guo B, Liu D, Xiong H, Wang Y, Du H.(PubMed)
(484) A novel inflammatory pathway mediating rapid hepcidin-independent hypoferremia by Guida C1, Altamura S2, Klein FA3, Galy B3, Boutros M4, Ulmer AJ5, Hentze MW6, Muckenthaler MU2.(PubMed)
(485) Prediction of iron deficiency in chronic inflammatory rheumatic diseaseanaemia by Baumann Kurer S1, Seifert B, Michel B, Ruegg R, Fehr J.(PubMed)
(486) Changes in Echocardiographic Parameters in Iron Deficiency Patients with Heart Failure and Chronic Kidney Disease Treated with Intravenous Iron by Toblli JE1, Di Gennaro F2, Rivas C2.(PubMed)
(487) Antimicrobial copper's potential.[No authors listed](PubMed)
(488) Effects of in-feed copper and tylosin supplementations on copper andantimicrobial resistance in fecal enterococci of feedlot cattle by Amachawadi RG1, Scott HM, Aperce C, Vinasco J, Drouillard JS, Nagaraja TG.(PubMed)
(489) Copper and immunity by Percival SS1.(PubMed)
(490) The immune system as a physiological indicator of marginal copper status? by Bonham M1, O'Connor JM, Hannigan BM, Strain JJ.(PubMed)
(491) Molecular basis for antioxidant enzymes in mediating copper detoxification in the nematode Caenorhabditis elegans by Song S1, Zhang X1, Wu H1, Han Y2, Zhang J1, Ma E1, Guo Y2.(PubMed)
(492) The effects of coadministration of dietary copper and zinc supplements on atherosclerosis, antioxidant enzymes and indices of lipid peroxidation in the cholesterol-fed rabbit by Alissa EM1, Bahijri SM, Lamb DJ, Ferns GA.(PubMed)
(493) Is copper pro- or anti-inflammatory? A reconciling view and a novel approach for the use of copper in the control of inflammation by Berthon G1(PubMed)
(494) Effect of a topical copper indomethacin gel on inflammatory parameters in a rat model of osteoarthritis by Yassin NZ1, El-Shenawy SM1, Abdel-Rahman RF1, Yakoot M2, Hassan M3, Helmy S4.(PubMed)
(495) Enhanced analgesic properties and reduced ulcerogenic effect of a mononuclear copper(II) complex with fenoprofen in comparison to the parent drug: promising insights in the treatment of chronic inflammatory diseases by Agotegaray M1, Gumilar F2, Boeris M3, Toso R3, Minetti A2.(PubMed)
(496) Nutraceuticals of anti-inflammatory activity as complementary therapy for rheumatoid arthritis by Al-Okbi SY1.(PubMed)
(497) Copper homeostasis in the CNS: a novel link between the NMDA receptor and copper homeostasis in the hippocampus by Schlief ML1, Gitlin JD.(PubMed)
(498) Effect of sex hormones on copper, zinc, iron nutritional status and hepatic lipid peroxidation in rats by Wachnik A1, Biró G, Biró L, Korom M, Gergely A, Antal M.(PubMed)
(499) Copper-zinc superoxide dismutase deficiency impairs sperm motility and in vivo fertility by Garratt M1, Bathgate R, de Graaf SP, Brooks RC.(PubMed)
(500) Iron and copper in male reproduction: a double-edged sword by Tvrda E1, Peer R, Sikka SC, Agarwal A.(PubMed)
(501) Interactions of peptide amidation and copper: novel biomarkers and mechanisms of neural dysfunction by Bousquet-Moore D1, Prohaska JR, Nillni EA, Czyzyk T, Wetsel WC, Mains RE, Eipper BA.(PubMed)
(502) Deficient copper concentrations in dried-defatted hepatic tissue from ob/ob mice: A potential model for study of defective copper regulation in metabolic liver disease by Church SJ1, Begley P1, Kureishy N1, McHarg S1, Bishop PN1, Bechtold DA2, Unwin RD3, Cooper GJ4.(PubMed)
(503) Update on anemia and neutropenia in copper deficiency by Lazarchick J1.(PubMed)
The Obesity' Research and Studies: The Effective of Vitamin C
Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Vitamin C, also known as L-ascorbic acid, is a water-soluble vitamin, found in fresh fruits, berries and green vegetables. It is best known for its free radical scavengers activity and regenerating oxidized vitamin E for immune support.
Vitamin C deficiency and incidence of obesity
Vitamin C and other nutrients deficiency not only are associated to the risk of Obesity(807) but also enhances the risk of lipids, inflammation and insulin resistance(808). According to the research team at Universidad Autónoma de Querétaro, there is an associated link between Obesity and Zinc and vitamins A and C concentration in women from rural Mexico, in a fasting blood sample analysis (809).
Although genetic susceptibility to obesity is associated with gene polymorphisms affecting biochemical pathways which also impacted by specific foods and nutrients. According to Dr. Johnston CS., vitamin C depletion is associated to positively related to body mass, individuals with adequate vitamin C status oxidize 30% more fat during a moderate exercise bout than individuals with low vitamin Cstatus(810)
Vitamin C, the protective effect against obesity
Endothelial dysfunction has found to be associated to the incidence of obesity(811). The study of 76 healthy subjects (50 men and 26 women aged 21-45 years) obese subject, showed a positive effect of vitamin Cand indomethacin in reduced oxidative stress contributed to endothelial dysfunction in human obesity(812).
In the evaluation of the potential inhibitory activity on α-glucosidase and pancreatic lipase of Citrus spp. fruits of Spanish origin, grapefruit, containing higher contents of phytochemicals, vitamin C, is found to have a great value for nutrition and treatment of diet-related diseases(813).
L-Ascorbic acid, in the study of whether the vitamin would facilitate the anti-obesity effects of chitosan and psyllium husk in vivo, indicated that addition of vitamin C in diet influences the reduction in body weight gain and food efficiency ratio, and increases in total fecal weight and fecal fat excretion in guinea pigs fed a high-fat diet(814).
Taking altogether, deficiency of vitamin C and other nutrients are associated to increase risk of obese incidence. Vitamin C may be effective in induced weight loss for obese subjects due to its positive interaction in inhibiting oxidative stress causes of endothelial dysfunction. Daily ingestion of high-dose vitamin C may be considered safe, but in rare incidence, overdoses in a prolonged period of time, may cause intra-renal oxalate crystal deposition, a fatal nephrotoxicity(815)(816).
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Vitamin C, also known as L-ascorbic acid, is a water-soluble vitamin, found in fresh fruits, berries and green vegetables. It is best known for its free radical scavengers activity and regenerating oxidized vitamin E for immune support.
Vitamin C deficiency and incidence of obesity
Vitamin C and other nutrients deficiency not only are associated to the risk of Obesity(807) but also enhances the risk of lipids, inflammation and insulin resistance(808). According to the research team at Universidad Autónoma de Querétaro, there is an associated link between Obesity and Zinc and vitamins A and C concentration in women from rural Mexico, in a fasting blood sample analysis (809).
Although genetic susceptibility to obesity is associated with gene polymorphisms affecting biochemical pathways which also impacted by specific foods and nutrients. According to Dr. Johnston CS., vitamin C depletion is associated to positively related to body mass, individuals with adequate vitamin C status oxidize 30% more fat during a moderate exercise bout than individuals with low vitamin Cstatus(810)
Vitamin C, the protective effect against obesity
Endothelial dysfunction has found to be associated to the incidence of obesity(811). The study of 76 healthy subjects (50 men and 26 women aged 21-45 years) obese subject, showed a positive effect of vitamin Cand indomethacin in reduced oxidative stress contributed to endothelial dysfunction in human obesity(812).
In the evaluation of the potential inhibitory activity on α-glucosidase and pancreatic lipase of Citrus spp. fruits of Spanish origin, grapefruit, containing higher contents of phytochemicals, vitamin C, is found to have a great value for nutrition and treatment of diet-related diseases(813).
L-Ascorbic acid, in the study of whether the vitamin would facilitate the anti-obesity effects of chitosan and psyllium husk in vivo, indicated that addition of vitamin C in diet influences the reduction in body weight gain and food efficiency ratio, and increases in total fecal weight and fecal fat excretion in guinea pigs fed a high-fat diet(814).
Taking altogether, deficiency of vitamin C and other nutrients are associated to increase risk of obese incidence. Vitamin C may be effective in induced weight loss for obese subjects due to its positive interaction in inhibiting oxidative stress causes of endothelial dysfunction. Daily ingestion of high-dose vitamin C may be considered safe, but in rare incidence, overdoses in a prolonged period of time, may cause intra-renal oxalate crystal deposition, a fatal nephrotoxicity(815)(816).
Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
References
(1) Adiposity and metabolic dysfunction in polycystic ovary syndrome by Sam S.(PubMed)
(2) A "kiss" before conception: triggering ovulation with kisspeptin-54 may improve IVF by Young SL.(PubMed)
(3.) Androgen hyperfunction and excessive heterosexual hair growth in women, with special attention to the polycystic ovarian syndrome by Lunde O1.(PubMed)
(4) Expression of anti-Müllerian hormone in letrozole rat model of polycystic ovary syndrome by Du DF1, Li XL, Fang F, Du MR.(PubMed)
(5) [Serum levels of anti-muller hormone in women with polycystic ovary syndromeand healthy women of reproductive age].[Article in Bulgarian] by Parahuleva N, Pehlivanov B, Orbecova M, Deneva T, Uchikova E.(PubMed)
(6) [Current opinions on the etiology and pathophysiology of hirsutism].[Article in Polish] by Krysiak R1, Kedzia A, Okopień B.(PubMed)
(7) The clinical evaluation of hirsutism by Somani N1, Harrison S, Bergfeld WF.(PubMed)
(8) Polycystic ovary syndrome and insulin: our understanding in the past, present and future by Mayer SB1, Evans WS, Nestler JE.(PubMed)
(9) Association of mean platelet volume with androgens and insulin resistance in nonobese patients with polycystic ovary syndrome by Dogan BA1, Arduc A2, Tuna MM1, Karakılıc E1, Dagdelen I1, Tutuncu Y1, Berker D1, Guler S1.(PubMed)
(10) Approach to the patient: contraception in women with polycystic ovary syndrome by Yildiz BO1.(PubMed)
(11) Polycystic ovarian syndrome (PCOS): a significant contributor to the overall burden of type 2 diabetes in women by Talbott EO1, Zborowski JV, Rager JR, Kip KE, Xu X, Orchard TJ.(PubMed)
(12) Prevalence of vitamin D deficiency in Slovak women with polycystic ovary syndrome and its relation to metabolic and reproductive abnormalities by Figurová J1, Dravecká I, Javorský M, Petríková J, Lazúrová I.(PubMed)
(13) Role of Insulin Sensitizers on Cardiovascular Risk Factors in Polycystic Ovarian Syndrome: A Meta-Analysis by Thethi TK1, Katalenich B2, Nagireddy P3, Chabbra P4, Kuhadiya N5, Fonseca V1.(PubMed)
(14) Acne in hirsute women by Lumezi BG1, Pupovci HL1, Berisha VL1, Goçi AU2, Gerqari A3.(PubMed)
(15) Obesity and polycystic ovary syndrome by Naderpoor N1, Shorakae S, Joham A, Boyle J, De Courten B, Teede HJ.(PubMed)
(16) Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan by Teede H1, Deeks A, Moran L.(PubMed)
(17) Metabolic Evidence of Diminished Lipid Oxidation in Women With Polycystic Ovary Syndrome. by Whigham LD1, Butz DE2, Dashti H3, Tonelli M3, Johnson LK1, Cook ME2, Porter WP4, Eghbalnia HR5, Markley JL6, Lindheim SR7, Schoeller DA8, Abbott DH9, Assadi-Porter FM10.(PubMed)
(18) Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis by Barry JA1, Azizia MM1, Hardiman PJ2.(PubMed)
(19) Risk of cancer among women with polycystic ovary syndrome: a Danish cohort study by Gottschau M1, Kjaer SK2, Jensen A1, Munk C1, Mellemkjaer L3.(PubMed)
(20) Polycystic ovary syndrome: metabolic consequences and long-term management by Carmina E1.(PubMed)
(21) Arterial stiffness is increased in asymptomatic nondiabetic postmenopausal women with a polycystic ovary syndrome phenotype by Armeni E1, Stamatelopoulos K, Rizos D, Georgiopoulos G, Kazani M, Kazani A, Kolyviras A, Stellos K, Panoulis K, Alexandrou A, Creatsa M, Papamichael C, Lambrinoudaki I.(PubMed)
(733) [Treatment of PCOS without IVF: weight loss, insulin-sensitizing agents].[Article in French] by Pugeat M1.(PubMed)
(734) A 12-week treatment with the long-acting glucagon-like peptide 1 receptor agonist liraglutide leads to significant weight loss in a subset of obese women with newly diagnosed polycystic ovary syndrome by Jensterle M1, Kravos NA1, Pfeifer M1, Kocjan T1, Janez A1.(PubMed)
(735) Body mass index and gonadotropin hormones (LH & FSH) associate with clinical symptoms among women with polycystic ovary syndrome by Esmaeilzadeh S, Andarieh MG1, Ghadimi R, Delavar MA.(PubMed)
(736) Obesity and polycystic ovary syndrome by Naderpoor N1, Shorakae S, Joham A, Boyle J, De Courten B, Teede HJ.(737)
(737) Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan by Teede H1, Deeks A, Moran L.(PubMed)
(738) A retrospective study of the pregnancy, delivery and neonatal outcome in overweight versus normal weight women with polycystic ovary syndrome by De Frène V1, Vansteelandt S2, T'Sjoen G3, Gerris J4, Somers S4, Vercruysse L4, De Sutter P4.(PubMed)
(807) High-fat feeding increases hepatic vitamin C synthesis and its circulatory mobilization in mice by Tranberg B1, Hansen AK, Lykkesfeldt J.(PubMed)
(808) Zinc, iron and vitamins A, C and e are associated with obesity, inflammation, lipid profile and insulin resistance in mexican school-aged children by García OP1, Ronquillo D, del Carmen Caamaño M, Martínez G, Camacho M, López V, Rosado JL.(PubMed)
(809) Zinc, vitamin A, and vitamin C status are associated with leptin concentrations and obesity in Mexican women: results from a cross-sectional study by García OP1, Ronquillo D, Caamaño Mdel C, Camacho M, Long KZ, Rosado JL.(PubMed)
(810) Strategies for healthy weight loss: from vitamin C to the glycemic response by Johnston CS.(PubMed)
(811) Mechanisms of endothelial dysfunction in obesity(Science direct)
(812) Obesity and body fat distribution induce endothelial dysfunction by oxidative stress: protective effect of vitamin C. by Perticone F1, Ceravolo R, Candigliota M, Ventura G, Iacopino S, Sinopoli F, Mattioli PL.(PubMed)
(813) Phytochemistry and biological activity of Spanish Citrus fruits by Gironés-Vilaplana A1, Moreno DA, García-Viguera C.(PubMed)
(814) Anti-obesity effects of chitosan and psyllium husk with L-ascorbic acid in guinea pigs by Jun SC1, Jung EY, Hong YH, Park Y, Kang Dh, Chang UJ, Suh HJ.(PubMed)
(815) Fatal vitamin C-associated acute renal failure by McHugh GJ, Graber ML, Freebairn RC.(PubMed)
(816) Ascorbic acid overdosing: a risk factor for calcium oxalate nephrolithiasis by Urivetzky M, Kessaris D, Smith AD.(PubMed)
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
References
(1) Adiposity and metabolic dysfunction in polycystic ovary syndrome by Sam S.(PubMed)
(2) A "kiss" before conception: triggering ovulation with kisspeptin-54 may improve IVF by Young SL.(PubMed)
(3.) Androgen hyperfunction and excessive heterosexual hair growth in women, with special attention to the polycystic ovarian syndrome by Lunde O1.(PubMed)
(4) Expression of anti-Müllerian hormone in letrozole rat model of polycystic ovary syndrome by Du DF1, Li XL, Fang F, Du MR.(PubMed)
(5) [Serum levels of anti-muller hormone in women with polycystic ovary syndromeand healthy women of reproductive age].[Article in Bulgarian] by Parahuleva N, Pehlivanov B, Orbecova M, Deneva T, Uchikova E.(PubMed)
(6) [Current opinions on the etiology and pathophysiology of hirsutism].[Article in Polish] by Krysiak R1, Kedzia A, Okopień B.(PubMed)
(7) The clinical evaluation of hirsutism by Somani N1, Harrison S, Bergfeld WF.(PubMed)
(8) Polycystic ovary syndrome and insulin: our understanding in the past, present and future by Mayer SB1, Evans WS, Nestler JE.(PubMed)
(9) Association of mean platelet volume with androgens and insulin resistance in nonobese patients with polycystic ovary syndrome by Dogan BA1, Arduc A2, Tuna MM1, Karakılıc E1, Dagdelen I1, Tutuncu Y1, Berker D1, Guler S1.(PubMed)
(10) Approach to the patient: contraception in women with polycystic ovary syndrome by Yildiz BO1.(PubMed)
(11) Polycystic ovarian syndrome (PCOS): a significant contributor to the overall burden of type 2 diabetes in women by Talbott EO1, Zborowski JV, Rager JR, Kip KE, Xu X, Orchard TJ.(PubMed)
(12) Prevalence of vitamin D deficiency in Slovak women with polycystic ovary syndrome and its relation to metabolic and reproductive abnormalities by Figurová J1, Dravecká I, Javorský M, Petríková J, Lazúrová I.(PubMed)
(13) Role of Insulin Sensitizers on Cardiovascular Risk Factors in Polycystic Ovarian Syndrome: A Meta-Analysis by Thethi TK1, Katalenich B2, Nagireddy P3, Chabbra P4, Kuhadiya N5, Fonseca V1.(PubMed)
(14) Acne in hirsute women by Lumezi BG1, Pupovci HL1, Berisha VL1, Goçi AU2, Gerqari A3.(PubMed)
(15) Obesity and polycystic ovary syndrome by Naderpoor N1, Shorakae S, Joham A, Boyle J, De Courten B, Teede HJ.(PubMed)
(16) Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan by Teede H1, Deeks A, Moran L.(PubMed)
(17) Metabolic Evidence of Diminished Lipid Oxidation in Women With Polycystic Ovary Syndrome. by Whigham LD1, Butz DE2, Dashti H3, Tonelli M3, Johnson LK1, Cook ME2, Porter WP4, Eghbalnia HR5, Markley JL6, Lindheim SR7, Schoeller DA8, Abbott DH9, Assadi-Porter FM10.(PubMed)
(18) Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis by Barry JA1, Azizia MM1, Hardiman PJ2.(PubMed)
(19) Risk of cancer among women with polycystic ovary syndrome: a Danish cohort study by Gottschau M1, Kjaer SK2, Jensen A1, Munk C1, Mellemkjaer L3.(PubMed)
(20) Polycystic ovary syndrome: metabolic consequences and long-term management by Carmina E1.(PubMed)
(21) Arterial stiffness is increased in asymptomatic nondiabetic postmenopausal women with a polycystic ovary syndrome phenotype by Armeni E1, Stamatelopoulos K, Rizos D, Georgiopoulos G, Kazani M, Kazani A, Kolyviras A, Stellos K, Panoulis K, Alexandrou A, Creatsa M, Papamichael C, Lambrinoudaki I.(PubMed)
(733) [Treatment of PCOS without IVF: weight loss, insulin-sensitizing agents].[Article in French] by Pugeat M1.(PubMed)
(734) A 12-week treatment with the long-acting glucagon-like peptide 1 receptor agonist liraglutide leads to significant weight loss in a subset of obese women with newly diagnosed polycystic ovary syndrome by Jensterle M1, Kravos NA1, Pfeifer M1, Kocjan T1, Janez A1.(PubMed)
(735) Body mass index and gonadotropin hormones (LH & FSH) associate with clinical symptoms among women with polycystic ovary syndrome by Esmaeilzadeh S, Andarieh MG1, Ghadimi R, Delavar MA.(PubMed)
(736) Obesity and polycystic ovary syndrome by Naderpoor N1, Shorakae S, Joham A, Boyle J, De Courten B, Teede HJ.(737)
(737) Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan by Teede H1, Deeks A, Moran L.(PubMed)
(738) A retrospective study of the pregnancy, delivery and neonatal outcome in overweight versus normal weight women with polycystic ovary syndrome by De Frène V1, Vansteelandt S2, T'Sjoen G3, Gerris J4, Somers S4, Vercruysse L4, De Sutter P4.(PubMed)
(807) High-fat feeding increases hepatic vitamin C synthesis and its circulatory mobilization in mice by Tranberg B1, Hansen AK, Lykkesfeldt J.(PubMed)
(808) Zinc, iron and vitamins A, C and e are associated with obesity, inflammation, lipid profile and insulin resistance in mexican school-aged children by García OP1, Ronquillo D, del Carmen Caamaño M, Martínez G, Camacho M, López V, Rosado JL.(PubMed)
(809) Zinc, vitamin A, and vitamin C status are associated with leptin concentrations and obesity in Mexican women: results from a cross-sectional study by García OP1, Ronquillo D, Caamaño Mdel C, Camacho M, Long KZ, Rosado JL.(PubMed)
(810) Strategies for healthy weight loss: from vitamin C to the glycemic response by Johnston CS.(PubMed)
(811) Mechanisms of endothelial dysfunction in obesity(Science direct)
(812) Obesity and body fat distribution induce endothelial dysfunction by oxidative stress: protective effect of vitamin C. by Perticone F1, Ceravolo R, Candigliota M, Ventura G, Iacopino S, Sinopoli F, Mattioli PL.(PubMed)
(813) Phytochemistry and biological activity of Spanish Citrus fruits by Gironés-Vilaplana A1, Moreno DA, García-Viguera C.(PubMed)
(814) Anti-obesity effects of chitosan and psyllium husk with L-ascorbic acid in guinea pigs by Jun SC1, Jung EY, Hong YH, Park Y, Kang Dh, Chang UJ, Suh HJ.(PubMed)
(815) Fatal vitamin C-associated acute renal failure by McHugh GJ, Graber ML, Freebairn RC.(PubMed)
(816) Ascorbic acid overdosing: a risk factor for calcium oxalate nephrolithiasis by Urivetzky M, Kessaris D, Smith AD.(PubMed)
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