Medical Advisor Journals

Friday, June 10, 2016

Herbal therapy: Popular Herbal Ginseng

Ginseng Asia is also known as Panax ginseng. Since it has been grown in the cold places in the Asian, Asian ginseng is considered as yang promoting, according to traditional Chinese medicine.
The herb has been used in traditional and Chinese medicine to promote yang and to improve cardiac function, short of breath, blood pressure. Panax ginseng can generates fluids and reduce thirst, to treat anxiety, insomnia, dizziness/headache, forgetfulness, impotence, diabetes, bleeding in the vagina not during period, etc.

Health Benefits
1. Erectile dysfunction
Panax ginseng has been used as yang promoting herb as it improves sexual desire, treat erectile dysfunction and impotent over thousands of year. In the investigation of the effectiveness of Korean ginseng and mountain ginseng (Panax ginseng CA Meyer) for treating erectile dysfunction, found that A total of 86 patients completed 8 weeks of treatment. The scores on the five domains of the IIEF after medication were significantly higher than the baseline scores in the group treated with TMGE (P<0.05), whereas no significant improvement was observed in the placebo group (P>0.05). Erectile function and overall satisfaction scores after medication were significantly higher in the TMGE group than in the placebo group (P<0.05). Erectile function of patients in the TMGE-treated group significantly improved, suggesting that TMGE could be utilized for improvingerectile function in male patients, according to "Effects of tissue-cultured mountain ginseng (Panax ginseng CA Meyer) extract on male patients witherectile dysfunction"by Kim TH, Jeon SH, Hahn EJ, Paek KY, Park JK, Youn NY, Lee HL.(1)

2. Antioxidant activity
In the evaluation of the extraction conditions of polysaccharides from the rhizomes of Panax japonicus C.A. Meyer and its antioxidant effect found that antioxidant activity exhibited Panax japonicus polysaccharides (PJP) had a good potential for antioxidant, according to "Optimization of polysaccharides from Panaxjaponicus C.A. Meyer by RSM and its anti-oxidant activity" by Wang R, Chen P, Jia F, Tang J, Ma F.(2)

3. Antipsychotic effect
In the investigation of Panax quinquefolium (PQ) and its significant neuroactive properties for its antipsychotic potential found that PQ blocked ketamine induced memory impairment in the passive avoidance paradigm. In the chronic studies, PQ reduced the ketamine induced enhanced immobility in the forced swim test and did not show extra-pyramidal side effects in bar test and wood block test of catalepsy. These behavioural effects were compared with standard drugs haloperidol and clozapine. Further PQ reduced DA and 5-HT content after chronic treatment, but not after acute administration, according to "Evaluation of the Antipsychotic Potential of Panax quinquefolium in Ketamine Induced Experimental Psychosis Model in Mice" by Chatterjee M, Singh S, Kumari R, Verma AK, Palit G.(3)

4. Anti-cancers
In the identification of Panax ginseng as a herb used in Asia for the prevention and treatment of various diseases, including cancer found that the results clearly indicate the structure-related activities in which the compound with less polar chemical structures possesses higher cytotoxic activity towards cancer cells, according to "The in vitro structure-related anti-cancer activity of ginsenosides and their derivatives" by Dong H, Bai LP, Wong VK, Zhou H, Wang JR, Liu Y, Jiang ZH, Liu L.(4)

5. Neuroprotective effect
In the analyzing Panax ginseng C.A. Meyer and its beneficial effects in cerebral ischemia and inhibition of the inflammatory cascade in sepsis found that Ginsenoside Rb1 (GRb1) partially inhibited the activation of nuclear factor-κB (NF-κB) pathway from 6 h to 72 h after ischemia and reperfusion onset, as determined by the expression of total and phosphorylated NF-κB/p65, inhibitor protein of κB (IκB)-α, and IκB-kinase complex (IKK)-α. All these results indicate that suppression of local inflammation after cerebral ischemia might be one mechanism that contributes to the neuroprotection of GRb1, according to "Suppression of local inflammation contributes to the neuroprotective effect of ginsenoside Rb1 in rats with cerebral ischemia" by Zhu J, Jiang Y, Wu L, Lu T, Xu G, Liu X.(5)

6. Immunological activities
In the study of Water-soluble ginseng oligosaccharides (designated as WGOS) with a degree of polymerization ranging from 2 to 10 were obtained from warm-water extract of Panax ginseng roots, found that WGOS were potent B and T-cell stimulators and WGOS-1 has the highest immunostimulating effect on lymphocyte proliferation among those purified fractions. It is hoped that the WGOS will be developed into functional food or medicine, according to "Structural characterization and immunological activities of the water-soluble oligosaccharides isolated from the Panax ginseng roots" by Wan D, Jiao L, Yang H, Liu S.(6)

7. Breast cancer
In the investigation the anticancer effects of warming and relieving cold phlegm formula (, WRCP), a mixture composed of the aqueous extracts of Aconitum carmichaeli, Rhizoma bolbostemmatis, Phytolacca acinosa, Panax notoginseng, and Gekko swinhonis G ū enther, combined with 5-fluorouracil (5-FU) on human breast cancer found that the treatment combination of WRCP and 5-FU was more effective in the inhibition of tumor growth than either agent alone and may have potentially additional benefit in improving the general condition and immunity of the mice with human breast cancer cell implants, according to "Anticancer effects of 5-fluorouracil combined with warming and relieving cold phlegm formula on human breast cancer" by Wang XL, Ma F, Wu XZ(7)

8. Type 2 diabetes
In the researches of Red ginseng (RG, Panax ginseng C.A. Meyer) and its effect for treating type 2 diabetes mellitus (DM) found that the evidence for the effectiveness of RG in controlling glucose in type 2 DM is not convincing. Few included studies with various treatment regimens prohibit definitive conclusions. More rigorous studies are needed to clarify the effects of RG on this condition, according to "Red ginseng for type 2 diabetes mellitus: A systematic review of randomized controlled trials" by Kim S, Shin BC, Lee MS, Lee H, Ernst E.(8)

9. Metabolic cardiovascular disease
In the identification of several traditional Chinese medicine and teirs effect on metabolic cardiovascular disease, authors emphasized that the relationship among axis of excessive ROS/RNS-mitochondrial dysfunction-apoptosis-atherosclerosis. They also introduce several traditional Chinese medicines such as Ophiopogon japonicus, butin, Panax ginseng, Pueraria lobata, Solanum lyratum and so on in the treatment of relevant diseases through anti-ROS/RNS mechanism. Moreover, the TCMs also can anti-cancer and anti-fatigue,which show the speciality of TCMs different from the single effect of classical western medicines, according to "[Mitochondrial dysfunction induced by excessive ROS/RNS-metabolic cardiovascular disease and traditional Chinese medicines intervention].[Article in Chinese]" by Zhang C, Liu J, Pan H, Yang X, Bian K.(9)

10. Prostate hyperplasia
in the demonstration of Panax ginseng's pharmacological activities on benign prostatic hyperplasia (BPH) found that 20(S)-Rg3 downregulated AR by facilitating the degradation of AR protein. WKRG and 20(S)-Rg3 were found to have new pharmacological activities against testosterone-induced prostate overgrowth. Given that red ginseng has been used safely in Asia for 1000 years, red ginsengand 20(S)-Rg3 could be potential therapeutic regimens for treating BPH, according to "Red ginseng and 20(S)-Rg3 control testosterone-induced prostate hyperplasia by deregulating androgen receptor signaling" by Bae JS, Park HS, Park JW, Li SH, Chun YS(10)

11. HL-60 cells
In the classification of Four new triterpene saponins, ginsenosides Rh (14)-Rh (17) ( 1- 4), along with two known compounds, 20( S)-ginsenoside Rg (2) and dammar-( E)-20(22),24-diene-3 β,6 α,12 β-triol, and theirs effect on HL-60 cells found that the isolated compounds were tested for IN VITRO cytotoxicity against HL-60 cells, according to "Four New Dammarane-Type Triterpene Saponins from the Stems and Leaves of Panax ginseng and Their Cytotoxicity on HL-60 Cells" by Li KK, Yao CM, Yang XW.(11)

12. Wound healing
In the investigation of herbal drugs (Panax ginseng, beta-sitosterol from Aloe vera, calycosin from Radix Astragali, and extracts from Hippophae rhamnoides L. and Angelica sinensis.) and theirs effect on wound healing indicated that the use of plants and their extracts as potential therapeutic agents with pro- or antiangiogenic activity. Since the anticancer and antiangiogenic properties of many phytomedicines have been amply reviewed elsewhere this paper will focus on the treatment of vascular insufficiency in wound healing, according to "Proangiogenic activity of plant extracts in accelerating wound healing - a new face of old phytomedicines" by Majewska I, Gendaszewska-Darmach E.(12)

13. Cardiovascular Disorders
In the evaluation of plethora of pharmacological properties of North Americanginseng (Panax quinquefolius) and Asian ginseng (Panax ginseng) found that Experimental studies have revealed a number of beneficial properties of ginseng, particularly in the area of cardiac protection, where ginseng and ginsenosides have been shown to protect the ischaemic and reperfused heart in a variety of experimental models. Emerging evidence also suggests that ginseng attenuates myocardial hypertrophy, thus blunting the remodelling and heart failure processes. However, clinical evidence of efficacy is not convincing, likely owing primarily to the paucity of well designed, randomized, controlled clinical trials, according to "Therapeutic Potential of Ginseng in the Management of Cardiovascular Disorders" by Karmazyn M, Moey M, Gan XT.(13)

14. Atherosclerosis
In the association of the herbal remedies on the prevention and treatment of AS found that mixed herbal preparations with multiple active ingredients may be preferable for the prevention and treatment of AS. Further rigorously designed pharmacological evaluation and multi-centred clinical trials are warranted, according to "Herbal Remedies Supply a Novel Prospect for the Treatment of Atherosclerosis: A Review of Current Mechanism Studies" by Zeng Y, Song JX, Shen XC.(14)

15. Etc.

Side effects
1. The herb can cause tremors, nervousness, headache, vomiting, insomnia, nose bleeding, etc.
2. Please do not use Panax ginseng, if you have heart disease or taken heart problem medicine
3. Panax ginseng may interact with other medication, including aspirin, Warfarin/Coumadin, etc.
4. Do not use the herb if you are pregnant
5. Etc.

B. Ginseng North America

North America Ginseng is also known as P. quinquefolius American ginseng (root), is considered as yin promoting, as the roots is growth from a hot area, according to traditional Chinese medicine. Ginseng North America has been used in TCM to quench thirst, heal deficiency of lungs and chronic cough and to treat tiredness and unrest, chronic fever, etc.

Health Benefits
1. Colorectal cancer
In the investigation of American ginseng (Panax quinquefolius L., Araliaceae) and its anti-cancer potentialfound that three genes were up-regulated (AKAPA8L, PMPCB and PDE5A) and three were down-regulated (PITPNA, DUS2L and RIC8A). Although further studies are needed to elucidate the mechanisms of action, our findings should expand the understanding of the molecular framework of American ginseng as an anti-cancer agent, according to "Characterization of gene expression regulated by American ginseng and ginsenoside Rg3 in human colorectal cancer cells" by Luo X, Wang CZ, Chen J, Song WX, Luo J, Tang N, He BC, Kang Q, Wang Y, Du W, He TC, Yuan CS.(a)

2. Cardiovascular disease
In the demonstration of emerging evidence suggests ginseng has therapeutic potential in cardiovascular disease found that ginseng treatment significantly decreased infarct size and myocardial apoptosis following I/R in WT mice, but not in either eNOS(-/-) mice or WT mice treated with LY294002. We conclude thatginseng treatment protects the heart from I/R injury via upregulation of eNOS expression. Our study suggests that ginseng may serve as a potential therapeutic agent to limit myocardial I/R injury, according to "North American ginsengprotects the heart from ischemia and reperfusion injury via upregulation of endothelial nitric oxide synthase" by Wu Y, Lu X, Xiang FL, Lui EM, Feng Q.(b)

3. Pediatric upper respiratory tract infection
In the evaluation of Panax quinquefolius (American ginseng root extract) standardized to contain 80% poly-furanosyl-pyranosyl-saccharides and theirs effect on upper respiratory tract infections in childdren found that standard doses of ginseng were well tolerated and merit additional evaluation with regard to treatment of pediatric upper respiratory tract infection, according to "Safety and tolerability of North American ginseng extract in the treatment of pediatric upper respiratory tract infection: a phase II randomized, controlled trial of 2 dosing schedules" by Vohra S, Johnston BC, Laycock KL, Midodzi WK, Dhunnoo I, Harris E, Baydala L.(c)

4. Glycemia and insulinemia
In the assessment the evidence indicates that the glycemia-lowering effect of American ginseng root may be batch dependent. found that American ginsengdecreased postprandial glycemia and insulinemia; however, 40% of the batches did not reduce glycemia with the anticipated magnitude, irrespective of their saponin composition, according to "Five batches representative of Ontario-grown American ginseng root produce comparable reductions of postprandial glycemia in healthy individuals" by

Dascalu A, Sievenpiper JL, Jenkins AL, Stavro MP, Leiter LA, Arnason JT, Vuksan V.(d)

5. Etc.

Side effects
Similar to Panax ginseng

Traditional Chinese Medicine Herbal Therapy - Popular Chinese Herbs – Bai Zhi (Radix Angelicae Dahuricae)

Ingredients
1. Imperatorin
2. Courmarins
3. Skimmin
4. Isoimperatorin;oxypeucedanin
5. Oxypeucedanin hydrate
6. Phellopterin
7. Byakangelicin;tert-O-methylbyakangelicin
8. Coumarin glycosides
9. Nodakenin;3-hydroxy-marmesinin
10. Tert-O-D-glu-copyranosylbyakangelicin
11. Sec-O-beta-D-glucopyranosyl byakangeliein
12. Scopolin
13. 8-O-beta-D-glucopyranosyl xanthotoxol
14. Tert-O-beta-D-glucopyranosyl heraclenol
15. Adeno-sine.
16. Etc.

Health Benefits
1. Skin whitening
Two coumarin compounds, isoimperatorin and and imperatorin have exerted the poperty in lowering the mRNA level of tyrosinase as result of that bai zhi may be considered as new whitening agent in cosmetics, according to the study of “New cosmetic agents for skin whitening from Angelica dahurica” by Cho YH, Kim JH, Park SM, Lee BC, Pyo HB, Park HD(1).

2. Vasodilatation activity
Imperatorin extracted from Bai Zhi has shown the ability of induced vasodilatation regulated by nitric oxide by signifificantly attenuated to 24.88%+/-4.06%, as the result showed that Bai zhi may be beneficial for treating elevtile dysfunction, according to the study of “Imperatorin is responsible for the vasodilatation activity of Angelica Dahurica var. Formosana regulated by nitric oxide in an endothelium-dependent manner” by Nie H, Meng LZ, Zhou JY, Fan XF, Luo- Y, Zhang GW.(2).

3. Antioxidant activities
Crude polysaccharides (CADPs), isolated from the roots of Angelica dahurica by H(2) has found to significantly inhibit lipid peroxidation, chelate Fe(2+) , and scavenge HO(.) radicals, according to the study of “Chemical composition and antioxidant activities of different polysaccharides from the roots of Angelica dahurica” by Xu SF, Ye YP, Li XY, Chen FY.(3).

4. Anti-inflammatory activity
Ethanolic extract (ADEE) of Bai Zhi has shown the property of anti-inflammatory activity acting via the suppression of the NF-κB pathwayaccording to the “Anti-inflammatory activity of Angelica dahurica ethanolic extract on RAW264.7 cells via upregulation of heme oxygenase-1” by Lee MY, Lee JA, Seo CS, Ha H, Lee H, Son JK, Shin HK.(4).

5. Anti-asthmatic effects
Ethanolic extract (AD) of Bai zhi has reduced airway inflammation and suppressed oxidative stress in the OVA-induced asthma model, partly via induction of heme oxygenase (HO)-1, according to the study of ” Anti-asthmatic effects of Angelica dahurica against ovalbumin-induced airway inflammation via upregulation of heme oxygenase-1″ by Lee MY, Seo CS, Lee JA, Lee NH, Kim JH, Ha H, Zheng MS, Son JK, Shin HK.(5).

6. Anti cancers and tumors
Isolation of six furanocoumarins from the root extract of Angelica dahurica, including hexane have demonstrated a significant inhibition on the proliferation of cultured human tumor cells such as A549 (non small cell lung), SK-OV-3 (ovary), SK-MEL-2 (melanoma), XF498 (central nervous system) and HCT-15 (colon), according to the study of “Antiproliferative effect of furanocoumarins from the root of Angelica dahurica on cultured human tumor cell lines” Kim YK, Kim YS, Ryu SY.(6).

7. Sepsis
Isolation of furanocoumarins from Bai Zhi has shown the ability of decreased the plasma levels of tumor necrosis factor-alpha and alanine aminotransferase in mice, according to the study of “Agents protecting against sepsis from the roots of Angelica dahurica” by Song DK, Kim JY, Li G, Lee KS, Seo CS, Yan JJ, Jung JS, Kim HJ, Chang HW, Son JK.(7).

8. Etc.

Side Effects
1. Bai Zhi may cause allergic effect to certain people
2. It may cause may cause dermatitis as a result of chemical compound furocoumarins which increases skin sensitivity to sunlight(a)
3. It may increase the rate of respiration, blood pressure, decrease pulse rate, increases saliva production
4. Overdoses may cause vomiting convulsions
5. Etc.

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

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Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/16676120
(2) http://www.ncbi.nlm.nih.gov/pubmed/20082250
(3) http://www.ncbi.nlm.nih.gov/pubmed/21674784
(4) http://www.ncbi.nlm.nih.gov/pubmed/21272610
(5) http://www.ncbi.nlm.nih.gov/pubmed/21146576
(6) http://www.ncbi.nlm.nih.gov/pubmed/17143927
(7) http://www.ncbi.nlm.nih.gov/pubmed/15684506
(a) http://www.pfaf.org/user/Plant.aspx?LatinName=Angelica+dahurica

The Holistic prevention, management and treatment of Polycystic Ovarian Syndrome: Phytochemicals Tanshinone, Berberine and Curcimin

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Polycystic Ovarian Syndrome

Polycystic Ovarian Syndrome is defined as endocrinologic diseases among reproductive-age women caused by undeveloped follicles clumping on the ovaries that interferes with the function of the normal ovaries associated with a high risk for metabolic disorder(1) as resulting of enlarged ovaries(2), leading to hormone imbalance(excessive androgen and anti-müllerian hormone (AMH) )(1)(3)(4)(5), induced Hirsutism(6)(7), reproductive disorder(10(12)), risks of type 2 diabetes(9)(10)(11), metabolic syndrome(10)(12) and early cardiovascular disease(8)(13), acne(10)(14), endometrial cancer(18)(19),weight gain and obesity(15)(16)(17). The syndrome effects over 5% of women population or 1 in 20 women.
Unfortunately, according to studies, women with PCOs after the reproductive age, are associated to continuously increase risk of type II diabetes, with no increasingaltered glucose tolerance(20), CVD and hypertension(21).

The prevention and management

Polycystic ovary syndrome (PCOS) is unpreventable in Western medicine. Early diagnosis and treatment may reduce risk of its complications, including infertility, metabolic syndrome, obesity, diabetes, cardiovascular diseases, stroke, etc.

Although PCOS cannot be completely avoided, strengthening immunity has shown a significant reduction of chronic inflammatory diseases(266)(267)(268).

The Phytochemicals

1. Tanshinone
Tanshinones, a class of phytochemicals found abundantly in Salvia miltiorrhiza (Danshen or Tanshen in Chinese) has shown to process several pharmacological effects including anti-inflammatory(596), antioxidative stress(595)(597), antisenile dementia(598), antiplatelet aggregation(593), anti atherosclerosis(599), hypertension(600), and ischemic stroke(594) and anticancer activities(592)(593), etc. Recent study if a total of 100 eligible women with PCOs meeting certain criteria recruited from four centers in China, conducted by First Affiliated Hospital of Heilongjiang University of Chinese Medicine, suggested that tanshinones ameliorate excessive androgens by inhibiting steroid hormone produced by the theca cells in the ovary(601)(602) and improve insulin resistance and glucose metabolism(602)(603). Dr. Wenjuan Shen and the research team also said " CHM can regulate and strengthen the hormonal systems of the whole body and is a natural approach for treating PCOS. The significant advantages of CHM are that it provides several options for the safe, effective, multitargeted treatment of various aspects of PCOS including hyperandrogenism and poor quality of life"(604).

2. Berberine
Berberine, a phytochemical found in many herbs, including Berberis aquifolium (Oregon grape), Berberis vulgaris (barberry), Berberis aristata (tree turmeric)], Hydrastis canadensis, etc., has been used in traditional medicine over thousand years for treatment of microbial infections(605)(606)(607)(608), trachoma(609), ,leishmaniasis(610).. Epedemiological studies suggested that the phytochemicals may also be effective for treatment of diabetes(611)(612), dyslipidemias(613)(614), hypertention(615), insulin resistance and the metabolic syndrome(616). cancers(617)(618)(619), etc.
Recent studies also showed that berberine also exerts its health benefits by improving some of the metabolic and hormonal derangements in a group of Eighty-nine subjects with PCOS and IR Chinese women with PCOS(620). When compare to metformin (MET), the phytochemical Berberine showed decrease in waist circumference and waist-to-hip ratio, fasting plasma glucose, fasting insulin, homeostasis model assessment for IR, area under the curve of insulin, cholesterol and triglycerides as well as increase in high-density lipoprotein cholesterol and sex hormone-binding(621). In combination with Letrozole for treatment of PCOs, the phytochemical showed the effectiveness in lowering blood sugar levels in db/db mice and exerted anti-dyslipidemia in human(622)

3. Curcimin
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia. (See Turmeric in the top 5 anti inflammation foods for the use of the herb in traditional medicine).
Immunohistochemical expression of VEGF may be associated to the pathophysiology of PCOS(623) as VEGF concentrations are found to increase in women with polycystic ovaries(624). Curcumin, according to the First Affiliated Hospital, Chongqing Medical University, lower the expression of VEGF in ovarian tissues of PCOS in high- and low-dose administrative rat model, and may have certain therapeutic effect on PCOS(625).

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

References
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(608) Conjugating berberine to a multidrug efflux pump inhibitor creates an effective antimicrobial by Ball AR1, Casadei G, Samosorn S, Bremner JB, Ausubel FM, Moy TI, Lewis K.(PubMed)
(609) Berberine, a potential drug for trachoma.[Article in English, French] by Khosla PK1, Neeraj VI, Gupta SK, Satpathy G.(PubMed)
(610) Antifungal, Antileishmanial, and Cytotoxicity Activities of Various Extracts of Berberis vulgaris (Berberidaceae) and Its Active Principle Berberine by Mahmoudvand H1, Ayatollahi Mousavi SA2, Sepahvand A3, Sharififar F4, Ezatpour B5, Gorohi F6, Saedi Dezaki E2, Jahanbakhsh S1.(PubMed)
(611) Application of berberine on treating type 2 diabetes mellitus by Pang B1, Zhao LH2, Zhou Q3, Zhao TY1, Wang H1, Gu CJ1, Tong XL1.(PubMed)
(612) Efficacy of berberine in patients with type 2 diabetes mellitus by Yin J1, Xing H, Ye J.(PubMed)
(613) The effects of berberine on hyperhomocysteinemia and hyperlipidemia in rats fed with a long-term high-fat diet by Chang XX1, Yan HM, Xu Q, Xia MF, Bian H, Zhu TF, Gao X.(PubMed)
(614) Berberine decreases cholesterol levels in rats through multiple mechanisms, including inhibition of cholesterol absorption by Wang Y1, Yi X2, Ghanam K2, Zhang S3, Zhao T3, Zhu X3.(PubMed)
(615) Nutraceuticals for treatment of high blood pressure values in patients with metabolic syndrome by Rozza F1, de Simone G, Izzo R, De Luca N, Trimarco B.(PubMed)
(616) Cheng Z, Guo S, Copps K, Dong X, Kollipara R, Rodgers JT et al. (November 2009). "Foxo1 integrates insulin signaling with mitochondrial function in the liver". Nature Medicine 15 (11): 1307–11. doi:10.1038/nm.2049.PMID 19838201.
(617)Akt signaling is associated with the berberine-induced apoptosis of human gastric cancer cells by Yi T1, Zhuang L, Song G, Zhang B, Li G, Hu T.(PubMed)
(618) Berberine induces autophagic cell death and mitochondrial apoptosis in liver cancer cells: the cellular mechanism by Wang N1, Feng Y, Zhu M, Tsang CM, Man K, Tong Y, Tsao SW(PubMed)
(619) Berberine induces apoptosis in SW620 human colonic carcinoma cells through generation of reactive oxygen species and activation of JNK/p38 MAPK and FasL by Hsu WH1, Hsieh YS, Kuo HC, Teng CY, Huang HI, Wang CJ, Yang SF, Liou YS, Kuo WH.(PubMed)
(620) A clinical study on the short-term effect of berberine in comparison to metformin on the metabolic characteristics of women with polycystic ovary syndrome by Wei W, Zhao H, Wang A by Sui M, Liang K, Deng H, Ma Y, Zhang Y, Zhang H, Guan Y.(PubMed)
(621) Effect of Berberine on Hormonal and Metabolic Features in Obese Women With Polycystic Ovary Syndrome (PCOS)14:32 EST 15th January 2014 |BioPortfolio
(622) Developmental toxicity evaluation of berberine in rats and mice by Jahnke GD, Price CJ, Marr MC, Myers CB, George JD.(PubMed)
(623) Role of vascular endothelial growth factor in women with PCO and PCOS: a systematic review.

Peitsidis P1, Agrawal R.(PubMed)
(624) Serum vascular endothelial growth factor concentrations and ovarian stromal blood flow are increased in women with polycystic ovaries.
Agrawal R1, Sladkevicius P, Engmann L, Conway GS, Payne NN, Bekis J, Tan SL, Campbell S, Jacobs HS.(PubMed)
(625) Effect of curcumin on expression of VEGF in polycystic ovary syndrome rat models by WANG Lian-lian, LI Cong, MENG Jiang-ping, YANG Xi (Journal of Shanghai, Jiaotong Uncersity)

Most Common Disease of elder: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Polymyalgia Arthritis (Rheumatica): The Individual herbs - Willow bark

B.2. Herbal and Traditional Chinese medicine
Herbal medicine from different cultures have been found effectively in reduced symptoms and treatment for patient with Polymyalagia Arthritis (Rheumatica), including

B.2.1. Individual herb

4. Willow bark

A herbal medicine used over thousands of years for treatment as an anti-inflammatory, antipyretic, and analgesic advocate in many culture. According to the University College Dublin, in the testing of healthy adult, polyphenols found in willow bark (CMW) expressed significantly antiinflammatory properties through its polyphenols anti oxidant effect, by inhibiting pro inflammatory cytokines IL-1β, IL-6, and TNFα. inducing pain upon movement of joints specific to the knee and lower back.(204).
In the trail of total of 78 patients (39 willow bark extract, 39 placebo),. researcher sat the Universität Tübinge showed that Willow bark extract reduces pain, stiffness and improve physical function
(205), particular, pain reduction in short and long term usage for patients suffering from musculoskeletal disorders (MSD)(206).

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
References

(204) An in vivo study examining the antiinflammatory effects of chamomile, meadowsweet, and willow bark in a novel functional beverage by Drummond EM1, Harbourne N, Marete E, Jacquier JC, O'Riordan D, Gibney ER.(PubMed)(205) Efficacy and tolerability of a standardized willow bark extract in patients with osteoarthritis: randomized placebo-controlled, double blind clinical trial by Schmid B1, Lüdtke R, Selbmann HK, Kötter I, Tschirdewahn B, Schaffner W, Heide L.(PubMed)
(206) Willow bark extract STW 33-I in the long-term treatment of outpatients with rheumatic pain mainly osteoarthritis or back pain by Uehleke B1, Müller J, Stange R, Kelber O, Melzer J.(PubMed)

Most Common Diseases of 50Plus:The Research and Studies of Coronary heart disease - The Diet to prevent Coronary heart disease

Cardiovascular disease is defined as medical conditions affecting the cardiovascular system, including heart, blood vessels(arteries and veins).

Beside cancer, heart disease kills more than 2,000 Americans everyday. Approximately 60 million Americans have heart disease.
There are many causes of heart diseases. Most of heart diseases are caused by high blood pressure contributes to hardening of the arteries. High levels of bad cholesterol (LDL) build up in the arteries as a result of uncontrolled diet with high levels of saturated fat and trans fat. All these add to the formation of atherosclerosis lesions and eventually arterial blockage or anything that serves to damage the inner lining of blood vessels and impedes the transportation of oxygen and nutrition to the heart can be defined as a risk of heart disease.

Coronary heart disease
Coronary heart disease is defined as a condition of narrowing coronary arteries that lead to blockage of the blood flow in the arteries as a result of hardening arterial wall, cholesterol building up in the arteries, chemicals, such as cadmium clog up arteries, etc. affecting the small blood vessels that supply blood and oxygen to the heart. Coronary heart disease (CHD) is the leading cause of death in the United States.

Diet to prevent Coronary heart disease

The aim of diet is to reduce the risk of underlining causes of coronary heart diseases, such as lowering cholesterol, lower blood pressure, reduce the risk of diabetes, lipid perioxidation, etc., causes of the diseases
1. Dulse is a red seaweed of genus Palmaria, belong to Family Palmariaceae that grows attached to rocks by a “holdfast” in the North Atlantic and Northwest Pacific. It is commonly used in Ireland and Atlantic Canada both as food and medicinally and is now shipped around the globe. Dulse is found in many health food stores or fish markets or can be ordered directly from local distributors.
a. Health benefits
In the assessment of nutritional and physiological properties of edible seaweeds is presented. Seaweeds are traditionally consumed in Asia as sea vegetables found that Seaweeds showed important functional activities, such as antioxidant, antimutagenic and anticoagulant effect, antitumor activity, and an important role in the modification of lipid metabolism in human body. In conclusion, seaweeds have a high nutritional value, therefore an increase in their consumption, would elevate the foods offer to population, according to “[Nutritional evaluation and physiological effects of edible seaweeds].[Article in Spanish]” by Jiménez-Escrig A, Goñi Cambrodón I.(43).

b. Antioxidant
In assessment of polyphenol content of the dulse extract of two grades of dulseharvested from Canadian Maritime locations differing in UV radiation exposure (i.e. west versus east coasts of Grand Manan Island, New Brunswick) and their antiodant effects found that The 1-butanol soluble extract from Grade 1 dulse(reduced UV-exposure) exhibited lower reducing activity versus Grade 2 dulse(greater UV exposure) reflecting a lower requirement for endogenous antioxidant protection. Grade 1 and 2 dulse extracts both inhibited (p0.03) AAPH-induced lipid peroxidation, but had no effect on AMVN-induced lipid peroxidation, demonstrating the aqueous nature of the antioxidants involved, according to “Extracts fromdulse (Palmaria palmata) are effective antioxidants and inhibitors of cell proliferation in vitro” by Yuan YV, Carrington MF, Walsh NA.(44).

c. Chlorophyll
Chlorophyll, a green pigment found in almost all plants, algae, and cyanobacteria, beside it is best known for its cleansing body and healing to vital organs properties. It also reduces the binding of carcinogens to DNA in the liver and other organs, thus reducing the risk of cancer according to the study of “Natural compounds in the human diet and their ability to bind mutagens prevents DNA-mutagen intercalation” by Osowski A, Pietrzak M, Wieczorek Z, Wieczorek J.(46), researchers indicated that in order to bind 50% of the mutagen in a complex, less than twice the concentration of chlorophyllin was needed……

2. Green tea
Green tea contains more amount of antioxidants than any drinks or food with the same volume, and is the leaves of Camellia sinensis, undergone minimal oxidation during processing, originated from China. Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Because of their health benefits, they have been cultivated for commercial purposes all over the world.
Cholesterol
In the investigation of theaflavin-enriched green tea extract in association with cholesterol levels of the study of “Cholesterol-lowering effect of a theaflavin-enriched green tea extract: a randomized controlled trial” by Maron DJ, Lu GP, Cai NS, Wu ZG, Li YH, Chen H, Zhu JQ, Jin XJ, Wouters BC, Zhao J.(47), researchers found that The theaflavin-enriched green tea extract is an effective adjunct to a low-saturated-fat diet to reduce LDL-C in hypercholesterolemic adults and is well tolerated.

3. Flax seed
Flax seed is native to the region of the eastern Mediterranean to India and also known as common flax or linseed. Flax is an erect annual plant, it can grow to 1.2 m tall. The leaves are 20–40 mm long and 3 mm broad.

b. Hyperlipidemia
In the examination of the effects of flax and sesame seeds mixture on Hyperlipidemia
found that Diet supplemented with flax and sesame seeds mixture in pregnant diabetic rats ameliorated lipid parameters, antioxidant enzyme activities, level of reduced glutathione and significantly decreased malonaldialdehyde levels, according to “Dietary polyunsaturated fatty acid prevents hyperlipidemia and hepatic oxidant status in pregnant diabetic rats and their macrosomic offspring” by Makni M, Sefi M, Garoui el M, Fetoui H, Boudawara T, Zeghal N.(52)

c. Cardiovascular diseases
In the research of Flaxseed and its effect on cardiovascular risk found thatflaxseed can modestly reduce serum total and low-density lipoprotein cholesterol concentrations, reduce postprandial glucose absorption, decrease some markers of inflammation, and raise serum levels of the omega-3 fatty acids, ALA and eicosapentaenoic acid. Data on the antiplatelet, antioxidant, and hypotensive effects of flaxseed, however, are inconclusive. More research is needed to define the role of this functional food in reducing cardiovascular risk, according to “Flaxseed and cardiovascular risk‘ by Bloedon LT, Szapary PO.(53).

d. Hypercholesterolemic atherosclerosis
In the evaluation of Flaxseed (Type I flaxseed) and CDC-flaxseed (Type II flaxseed) and theirs effect onhypercholesterolemic atherosclerosis found that Type II flaxseed reduced the development of atherosclerosis by 69%, according to “Reduction of hypercholesterolemic atherosclerosis by CDC-flaxseed with very low alpha-linolenic acid” by Prasad K, Mantha SV, Muir AD, Westcott ND.(54).

f. Omega 3 fatty acidsBesides well known for its benefits for the maintenance of a healthy cardio-vascular system, according to the study of “Omega-3 Fatty acids for cardiovascular disease prevention” by Defilippis AP, Blaha MJ, Jacobson TA, posted in PubMed(I) and proper ratio of Omega 3 and 6 fatty acid and prevent blood clotting, it also extends the portion of your cycle in which you are fertile, by promoting natural ovulation, according tothe study of “Postpartum ovarian activity in multiparous Holstein cows treated with bovine somatotropin and fed n-3 fatty acids in early lactation” by Carriquiry M, Dahlen CR, Weber WJ, Lamb GC, Crooker BA., posted in pubMed (55)

4. Blueberry
a. Antioxidant Capacity
In the investigation of Blueberry and blackberry wines commercially available in Illinois and theirs potential health benefits, found that fruit wines made from blueberries and blackberries may have potential health applications and therefore could contribute to the economy of the wine industry. Practical Application: The majority of wines are produced from grapes, but wine can also be produced from other fruits including blueberries and blackberries, which contain phenolic compounds that may contribute to human health, according to “Comparison of Chemical Composition and Antioxidant Capacity of Commercially Available Blueberry and Blackberry Wines in Illinois” by Johnson MH, Gonzalez de Mejia E.(56)

b. Metabolic Syndrome
In the classification of therapeutic roles of strawberries, blueberries, and cranberries in metabolic syndrome found that strawberries lowering total and LDL-cholesterol, but not triglycerides, and decreasing surrogate biomarkers of atherosclerosis (malondialdehyde and adhesion molecules); blueberries lowering systolic and diastolic blood pressure and lipid oxidation and improving insulin resistance; and low-calorie cranberry juice selectively decreasing biomarkers of lipid oxidation (oxidized LDL) and inflammation (adhesion molecules) in metabolic syndrome, according to “Strawberries, Blueberries, and Cranberries in the Metabolic Syndrome: Clinical Perspectives” by Basu A, Lyons TJ.(57).

c. Cardiovascular diseases
Since blue berry contains high amount of antioxidant, it reduces ROS production and the effects of oxidative stress due to ROS, apoptosis and improve cardiac function, according to “Mitochondrially targeted antioxidants for the treatment of cardiovascular diseases” by Subramanian S, Kalyanaraman B, Migrino RQ.(58).

5. Wolfberry is the common name for the fruit of two very closely related species, the genus of Lycium, belong to family Solanaceae, native to native to southeastern Europe and Asia.
a. Cholesterol
In the comparison of herbal extract SR10 of Radix Astragali, Radix Codonopsis and Cortex Lycii and its effect on lipoprotein oxidation found that SR10 inhibited erythrocyte hemolysis with IC50 value at 0.25 mg/ml and significantly prolonged low-density lipoprotein oxidation in vitro. SR10 attenuated platelet derived growth factor-BB-induced vascular smooth muscle cell proliferation by promoting cell cycle arrest at G0/G1 phase as well as inhibiting vascular smooth muscle cell migration. according to “Suppression of low-density lipoprotein oxidation, vascular smooth muscle cell proliferation and migration by a herbal extract of Radix Astragali, Radix Codonopsis and Cortex Lycii” by Chan JY, Koon JC, Leung PC, Che CT, Fung KP.(59).

b. Hypochlolesterolemic and antioxidative effects
In the researches of the hypocholesterolemic effect and potential of tyramine derivatives from Lycii Cortex Radicis (LCR), the root bark of lycium (Lyciumchenese Miller) in reducing lipid peroxidation found that The level of liver cholesterol was significantly lower in LCR1 and LCR2 groups than HF-control. Serum levels of TBARS were significantly lower only in LCR2 group when compared with HF-control group. From the observed results, we concluded that LCR can be utilized as a hypocholesterolemic ingredient in combination with ginger, especially for functional foods, according to “Study on the hypochlolesterolemic and antioxidative effects of tyramine derivatives from the root bark of Lycium chenese Miller” by Cho SH, Park EJ, Kim EO, Choi SW.(60).

c. Free radicals
In the observation of protective effects against oxidative stress in liver tissues of test mice of aqueous extract of Lycium barbarum (LBAE) and ethanol extract ofLycium barbarum (LBEE) found the extracts reduce liver damage and oxidative changes, according to “Effects of lycium barbarum aqueous and ethanol extracts on high-fat-diet induced oxidative stress in rat liver tissue” by Cui B, Liu S, Lin X, Wang J, Li S, Wang Q, Li S.(62)

6. Coriander is an annual herb, genus Coriandrum in the family Apiaceae, native to southern Europe and North Africa to southwestern Asia. All parts of the plant are edible, but the fresh leaves and the dried seeds are the parts most commonly used in cooking.
a. Antioxidant
Like most plants with spice taste, coriander contains high levels of antioxidant that helps to protect our body’s cells from oxidation damage, thus reducing the DNA alternation due to free radicals. A study found both the leaves and seed to contain antioxidants, but the leaves were found to have a stronger effect, accoridng to “Antioxidant activity in extracts from coriander” by Helle Wangensteen, Anne Berit Samuelsen, Karl Egil Malterud(66)
b. Hypolipidemic effect
In a study on rats researcher found that coriander seeds were found to have a significant hypolipidemic effect by lowering of levels of total cholesterol andtriglycerides, and increasing levels of high-density lipoprotein due to increasing synthesis of bile by the liver and the breakdown of cholesterol into other compounds, according to “Hypolipidemic effect of coriander seeds(Coriandrum sativum): mechanism of action” by Chithra V, Leelamma S.(67)

7. Eat plenty of Fruits, evgatables and reduce intake of red meats

Obesity and Obesity's complication - The association of Obesity on Renal Disease

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Obesity is a medical condition of excess body fat accumulated overtime, while overweight is a condition of excess body weight relatively to the height. According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered over weight, while a BMI of over 30 is an indication of obesity. According to the statistic, 68% of American population are either overweight or obese.

You can calculate your BMI index BMI= weight (kg)/ height (m2)

Renal Disease
Renal or kidney disease is defined as a condition of damage of tiny structures in kidney called nephrons that can lead to abnormal function of kidney in moving waste with no symptoms as the disease progress slowly over years.

The association of Obesity with Renal Disease
1. According to the study of "Mechanisms linking obesity, chronic kidney disease, and fatty liver disease: the roles of fetuin-A, adiponectin, and AMPK"by Ix JH, Sharma K. (Source from Division of Nephrology and Hypertension, Department of Medicine, University of California-San Diego/Veterans Affairs San Diego Healthcare System, CA 92093-0711, USA., J Am Soc Nephrol. 2010 Mar;21(3):406-12. Epub 2010 Feb 11), posted in PubMed, researchers found that Recent studies identify mechanisms common to both diseases linked through an interorgan communication orchestrated by fetuin-A and adiponectin. In liver andkidney, the energy sensor 5'-AMP activated protein kinase (AMPK) is pivotal to directing podocytes and hepatocytes to compensatory and potentially deleterious pathways, leading to inflammatory and profibrotic cascades culminating in end-organ damage. Regulation of these early upstream pathways may provide new therapeutic targets for these increasingly common sequelae of obesity.

2. In a study of "Biochemical study of oxidative stress markers in the liver,kidney and heart of high fat diet induced obesity in rats" by Noeman SA, Hamooda HE, Baalash AA. (Source from Medical Biochemistry Department, Faculty of Medicine, Tanta University, Egypt., nooman1234@hotmail.com, Diabetol Metab Syndr. 2011 Aug 3;3(1):17), posted in PubMed, researchers found that high fat diet-induced obesity is accompanied by increased hepatic, heart, and renal tissues oxidative stress, which is characterized by reduction in the antioxidant enzymes activities and glutathione levels, that correlate with the increase in MDA and PCO levels in most tissues. This may probably contribute to the additional progression of obesity related problems.

3. In a study of "[Obesity and chronic kidney disease]".[Article in Russian] by Bondar' IA, Klimontov VV, Simakova AI., Ter Arkh. 2011;83(6):66-70, posted in PubMed, researchers indicated that Obesity and overweight are now characterized as epidemics. It is shown that body overweight is associated with functional and structural changes in the kidneys,..., A decrease of body weight following lifestyle modification or bariatric surgery leads to reduction in albuminuria and eliminates hyperfiltration in obese subjects. Thus, prevention and treatment of obesity may reduce CKD incidence in general population.

4. In abstract of in a study of "[Overweight and obesity--risk factors in the development and progression of renal disease]" [Article in Slovak], by Sebeková K, Klassen A, Bahner U, Heidland A. (Source from Vedecko-výskumná základna Slovenskej zdravotníckej univerzity, Ustav preventívnej a klinickej medicíny, Bratislava, Slovenská republika., Vnitr Lek. 2004 Jul;50(7):544-9.) researchers found that Obesity-related renal disease may be prevented/postponed by an early weight reduction, by dietary intervention combined with physical exercise. In the advanced stages of renal disease benefits of weight reduction are minimal. Concomitant administration of angiotensin-converting-enzyme inhibitors or angiotensin II receptor 1 blockers exerts antiproteinuric effects and thereby aid in retarding the disease progression. Aimed prevention and treatment of obesityrepresent a challenge for the healthcare system. The concerted action of physicians, patients and the public health authorities is needed.

5. In a study of "The role of obesity and its bioclinical correlates in the progression of chronic kidney disease" by Chalmers L, Kaskel FJ, Bamgbola O. (Source from Department of Pediatrics, Oklahoma University Health Science Center, Oklahoma City, OK 73104, USA, Adv Chronic Kidney Dis. 2006 Oct;13(4):352-64.), posted in PubMed, researchers found that Reduced fetal protein synthesis contributes to oxidative glomerular injury and impairment of renal morphogenesis. Thus, kidneys are poorly equipped to handle physiologic stress that may result from the rapid body growth and programmed metabolic dysfunction later in life. Finally, in order to minimize morbidity of obesity-related kidney disease, preventive strategy must include optimal maternal health care, promotion of healthy nutrition and routine physical exercise, and early detection of CKD.

6. Etc.

Treatments of Obesity and Renal Disease
1. According to the study of "The role of the primary care physician in managing early stages of chronic kidney disease" by Coritsidis GN, Linden E, Stern AS. (Source from Mount Sinai Services, Elmhurst Hospital Center, Elmhurst, NY. coritsg@nychhc.org, Postgrad Med. 2011 Sep;123(5):177-85), posted in PubMed, researchers indicated in abstract that Recent increases inobesity, diabetes, and hypertension, along with the aging of the US population..... Nephrology evaluation at this point is essential to facilitate timely preparation for care of end-stage renal disease through preemptive transplantation or planned transition to dialysis. In addition to stringent control of underlying hypertension and/or diabetes, mineral metabolic parameters (serum parathyroid hormone, phosphorus, calcium, and bicarbonate) in patients with advancing CKD should be managed closely to avoid adverse effects on the cardiovascular and skeletal systems.

2. In a study of "A quick guide to evidence-based chronic kidney disease care for the primary care physician" by Fox CH, Voleti V, Khan LS, Murray B, Vassalotti J. (Source from University of Buffalo, Buffalo, NY, USA. chetfox@gmail.com, Postgrad Med. 2008 Jul 31;120(2):E01-6), posted in PebMed, researchers indicated that with the aging of the US population and the increase in hypertension, diabetes mellitus, and obesity, the prevalence of chronic kidney disease (CKD) is increasing in the United States,... there is limited knowledge and uptake of these guidelines because of their length and and complexity. Patients with CKD risk factors, hypertension, diabetes mellitus, cardiovascular disease, a family history of CKD, and those older than 60 years should be screened using 2 tests: 1) the estimated glomerular filtration rate and 2) the urinary albumin-creatinine ratio. These tests allow the diagnosis and stratification of CKD into 5 stages. This article synthesizes the key evidence-based behaviors and clinical action plan that primary care physicians can implement to treat CKD and its complications.

3. Etc.
Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

The Obesity' Research and Studies - Conjugated linoleic acid and Body fat mass

(1) "Conjugated linoleic acid reduces body fat mass in overweight and obese humans" by
Blankson H, Stakkestad JA, Fagertun H, Thom E, Wadstein J, Gudmundsen O.