Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Recipe attributed to Company's Coming Salads by Jean Pare
These can be prepared days ahead. Just what you need for the barbecue feast. Perhaps you should double the recipe.
large Spanish onion, sliced in thin ring 1
Cold water to cover
Granulated sugar 1 cup (250 ml)
Vinegar 1 cup (250 ml)
Cold water 1 cup (250 ml)
Cooking oil 1tbsp. (15 ml)
Slice peeled onion into the thinnest slices you can. A food slicer makes this a snap to do. Separate into rings and place in a bowl. Cover with lots of water. Let stand for 1 hour.
In small saucepan mix sugar, vinegar, water and cooking oil. Heat and stir until sugar dissolves. Drain onion. Pour sugar-vinegar mixture over onion. Let stand in refrigerator. Covered for at least 1 day, before serving. Serve 8 to 10.
Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Wednesday, June 15, 2016
Tuesday, June 14, 2016
Phytochemicals in Foods - The Effects of Limonene
Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Limonene
Limonene is a phytochemicals in the class of Monoterpenes, found abundantly in
cherries, citrus essential oils, spearmint, dill, garlic, celery, maize, rosemary, ginger, basil, etc.
Health benefits
1. Anti-inflammatory
In the investigation of the monoterpene D-limonene and its metabolites have been shown to exert chemopreventive and chemotherapeutic effects against different tumours in animal models and clinical trials, found that D-limonene is an effective inhibitor of lipopolysaccharide (LPS)-induced NO and prostaglandin E(2) production in RAW 264.7 cells. These inhibitory effects of D-limonene included dose-dependent decreases in the expression of iNOS and COX-2 proteins, according to "Limonene suppresses lipopolysaccharide-induced production of nitric oxide, prostaglandin E2, and pro-inflammatory cytokines in RAW 264.7 macrophages" by Yoon WJ, Lee NH, Hyun CG.(1)
2. Antibacterial effect
In the assessment that GC and MS were used for the analysis of Croatian Centaurium erythraea Rafn essential oil (obtained by hydrodistillation) and headspace (applying headspace solid-phase microextraction). The headspace contained numerous monoterpene hydrocarbons (the major ones were terpinene-4-ol, methone, p-cymene, γ-terpinene and limonene), found that the oil fractionation enabled identification of other minor compounds not found in total oil such as norisoprenoides, alk-1-enes or chromolaenin. The essential oil showed antimicrobial potential on Escherichia coli, Salmonella enteritidis, Staphylococcus aureus and Bacillus cereus. On the other hand, no antibacterial activity of the oil was observed on Pseudomonas fluorescens and Lysteria monocytogenes, according to "Volatile Organic Compounds from Centaurium erythraea Rafn (Croatia) and the Antimicrobial Potential of Its Essential Oil" by Jerković I, Gašo-Sokač D, Pavlović H, Marijanović Z, Gugić M, Petrović I, Kovač S(2)
3. Skin tumorigenesis
In the investigation of the effects of limonene on the growth of 7,12-dimethylbenz[a]anthracene (DMBA)-initiated and 12-O-tetradecanoylphorbol-13-acetate (TPA)-promoted skin tumor development, found that -limonene (50 and 100 mg/kg body weight) treatments to the mouse skin significantly reduced the TPA-induced (a) edema and hyperplasia (p < 0.001); (b) expression of cyclooxygenase-2; (c) ornithine decarboxylase activity (p < 0.001); and (d) [(3)H] thymidine incorporation into DNA (p < 0.001), In addition, treatment of -limonene effectively restored the level of reduced glutathione, glutathione peroxidase, glutathione reductase, glutathione S-transferase, catalase and malondialdehyde production in TPA-treated mouse skin. In a two-stage skin tumorigenesis study, limonenesignificantly reduced the tumor burden (p < 0.005) and tumor incidence as compared to DMBA/TPA-treated mice. -Limonene treatment also extended the latency period of tumor development from 4 to 9 weeks. Limonene treatment decreased the expression level of Ras, Raf and phosphorylation of extracellular signal-regulated protein kinase 1/2 in DMBA/TPA-induced tumors.according to "D-Limonene modulates inflammation, oxidative stress and Ras-ERK pathway to inhibit murine skin tumorigenesis" by Chaudhary SC, Siddiqui MS, Athar M, Alam MS.(3)
4. Antihyperlipidemic Effects
In the investigation of the antihyperlipidemic activities of the essential oil from the leaves of Pinus koraiensis SIEB (EOPK) that has been used as a folk remedy for heart disease, found that
EOPK up-regulated low density lipoprotein receptor (LDLR) at the mRNA level as well as negatively suppressed the expression of sterol regulatory element-binding protein (SREBP)-1c, SREBP-2, 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMGCR), fatty acid synthase (FAS) and glycerol-3-phosphate acyltransferase (GPAT) involved in lipid metabolism in HepG2 cells. Also, western blotting showed that EOPK activated LDLR and attenuated the expression of FAS at the protein level in the cells. Consistently, EOPK significantly inhibited the level of human acylcoenzyme A: cholesterol acyltransferase (hACAT)1 and 2 and reduced the low-density lipoprotein (LDL) oxidation activity. Furthermore, chromatography-mass spectrometry (GC-MS) analysis showed that EOPK, an essential oil mixture, contained camphene (21.11%), d-limonene (21.01%), α-pinene (16.74%) and borneol (11.52%), according to "Essential Oil of Pinus koraiensis Leaves Exerts Antihyperlipidemic Effects via Up-regulation of Low-density Lipoprotein Receptor and Inhibition of Acyl-coenzyme A: Cholesterol Acyltransferase" by Kim JH, Lee HJ, Jeong SJ, Lee MH, Kim SH.(4)
5. Antioxidant effects
In the evaluation of evaluate the antioxidant capacity and the acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activity of the peel essential oils from three Citrus species, C. aurantifolia Swingle, C. aurantium L., and C. bergamia Risso & Poit, found that the demonstrated antioxidant activity and procholinesterase properties of Citrus essential oils suggested their use as a new potential source of natural antioxidant to added as extra-nutrient for using in food industries as a valuable new flavor with functional properties for food or nutraceutical products with particular relevance to supplements for the elderly, according to "Comparative study on the antioxidant capacity and cholinesterase inhibitory activity of Citrus aurantifolia Swingle, C. aurantium L., and C. bergamia Risso and Poit. peel essential oils" by Tundis R, Loizzo MR, Bonesi M, Menichini F, Mastellone V, Colica C, Menichini F.(5)
6. Anti cancers
In the review attempted to collect all available published scientific literature of eight naturally occurring terpenoids and their effect on inhibition of tumor progression, found that literature survey revealed that triterpenoids, such as glycyrrhizic acid, ursolic acid, oleanolic acid, and nomilin, the diterpene andrographolide, and the monoterpenoids like limonene and perillic acid had shown immunomodulatory and antitumor activities. All of them could induce apoptosis in various cancer cells by activating various proapoptotic signaling cascades. Many of these terpenoids found to inhibit metastatic progression and tumor-induced angiogenesis, according to "Inhibition of tumor progression by naturally occurring terpenoids" by Kuttan G, Pratheeshkumar P, Manu KA, Kuttan R.(6)
7. Antigenotoxic properties
In the evaluation of the chemical composition and the DNA protective effect of the essential oils (EOs) from Lippia alba against bleomycin-induced genotoxicity, found that the EOs were not genotoxic in the SOS chromotest, but one of the major compound (limonene) showed genotoxicity at doses between 97 and 1549 mM. Both EOs protected bacterial cells against bleomycin-induced genotoxicity. Antigenotoxicity in the two L. alba chemotypes was related to the major compounds, citral and carvone, respectively. The results were discussed in relation to the chemopreventive potential of L. alba EOs and its major compounds, according to "Chemical composition and antigenotoxic properties of Lippia alba essential oils" by López MA, Stashenko EE, Fuentes JL.(7)
8. Microbial Effects
In the assessment of the composition of hydro-distilled and SC-CO(2) extracted oils. Nineteen constituents, which accounted for 89.32% of total constituents in HD oil, represented by limonene (4.31%), (Z)-β-ocimene (3.69%), terpinolene (22.24%), neryl acetate (36.19%), nerol (9.51%) and p-cymene-8-ol (2.61%) were identified. In SC-CO(2) extracted oil, 24 constituents representing 89.95% of total constituents were identified. Terpinolene (5.08%), germacrene D (2.17%), neryl acetate (51.62%), nerol (9.78%), geranyl acetate (2.06%), α-bisabolol (2.48%) and 1-nonadecanol (4.96%) were the dominating constituents anf their anti microbial effects, found that the oil exhibited moderate to high antimicrobial activity against fungi C. albicans (MIC 625 µg ml(-1)), A. parasiticus (MIC 312.5 µg ml(-1)), A. sydowii (MIC 312.5 µg ml(-1)), T. rubrum (MIC 625 µg ml(-1)), Gram-positive bacteria B. subtilis (MIC 625 µg ml(-1)) and Gram-negative bacteria P. aeruginosa (MIC 312.5 µg ml(-1)), according to "Composition and antimicrobial activity of the essential oil of Heracleum thomsonii (Clarke) from the cold desert of the western Himalayas" by Guleria S, Saini R, Jaitak V, Kaul VK, Lal B, Rahi P, Gulati A, Singh B.(8)
9. Antioxidant and anticarcinogenic effects
In the evaluation of the efficacy of fennel seed methanolic extract (FSME), such as flavonoids, terpenoids, alkaloids, phenols, and sterols; estragole (71.099%), gallic acid (18.895%), and L-limonene was the most prevalent monoterpene hydrocarbon (11.967%). for its antioxidant, cytotoxic, and antitumor activities and for its capacity to serve as a nontoxic radioprotector in Swiss albino mice, found that FSME may have remarkable anticancer potential against a breast cancer cell line (MCF7) and liver cancer cell line (Hepg-2). It also showed strong free radical-scavenging activity (100%). Thus, FSME may reduce oxidative stress and protect mouse cells from damage caused by reactive oxygen species. In addition, it could be used as a safe, effective, and easily accessible source of natural antioxidants to improve the oxidative stability of fatty foods during storage. FSME also exhibited an antitumor effect by modulating lipid peroxidation and augmenting the antioxidant defense system in EAC-bearing mice with or without exposure to radiation, according to "Antioxidant and anticarcinogenic effects of methanolic extract and volatile oil of fennel seeds (Foeniculum vulgare)" by Mohamad RH, El-Bastawesy AM, Abdel-Monem MG, Noor AM, Al-Mehdar HA, Sharawy SM, El-Merzabani MM.(9)
10. DNA protection and Anti tumors
In the assessment of the nutraceutical value of orange and lemon juices as well as two of their active compounds: hesperidin and limonene performed at three levels to evaluate different biological health promoter activities, found that Life-span experiments revealed that the lower concentrations of orange juice, hesperidin, andlimonene exerted a positive influence on the life span of Drosophila. Finally all substances showed cytotoxic activity, with hesperidin being least active. Taking into account the safety, antigenotoxicity, longevity, and cytotoxicity data obtained in the different assays, orange juice may be a candidate as a nutraceutical food as it (1) is not genotoxic, (2) is able to protect DNA against free radicals, and (3) inhibits growth of tumor cells, according to "Role of citrus juices and distinctive components in the modulation of degenerative processes: genotoxicity, antigenotoxicity, cytotoxicity, and longevity in Drosophila" by Fernández-Bedmar Z, Anter J, de La Cruz-Ares S, Muñoz-Serrano A, Alonso-Moraga A, Pérez-Guisado J.(10)
Etc.
Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/20625233
(2) http://www.ncbi.nlm.nih.gov/pubmed/22349896
(3) http://www.ncbi.nlm.nih.gov/pubmed/22318307
(4) http://www.ncbi.nlm.nih.gov/pubmed/22275303
(5) http://www.ncbi.nlm.nih.gov/pubmed/22260108
(6) http://www.ncbi.nlm.nih.gov/pubmed/21936626
(7) http://www.ncbi.nlm.nih.gov/pubmed/21931523
(8) http://www.ncbi.nlm.nih.gov/pubmed/21854172
(9) http://www.ncbi.nlm.nih.gov/pubmed/21812646
(10) http://www.ncbi.nlm.nih.gov/pubmed/21707429
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Limonene
Limonene is a phytochemicals in the class of Monoterpenes, found abundantly in
cherries, citrus essential oils, spearmint, dill, garlic, celery, maize, rosemary, ginger, basil, etc.
Health benefits
1. Anti-inflammatory
In the investigation of the monoterpene D-limonene and its metabolites have been shown to exert chemopreventive and chemotherapeutic effects against different tumours in animal models and clinical trials, found that D-limonene is an effective inhibitor of lipopolysaccharide (LPS)-induced NO and prostaglandin E(2) production in RAW 264.7 cells. These inhibitory effects of D-limonene included dose-dependent decreases in the expression of iNOS and COX-2 proteins, according to "Limonene suppresses lipopolysaccharide-induced production of nitric oxide, prostaglandin E2, and pro-inflammatory cytokines in RAW 264.7 macrophages" by Yoon WJ, Lee NH, Hyun CG.(1)
2. Antibacterial effect
In the assessment that GC and MS were used for the analysis of Croatian Centaurium erythraea Rafn essential oil (obtained by hydrodistillation) and headspace (applying headspace solid-phase microextraction). The headspace contained numerous monoterpene hydrocarbons (the major ones were terpinene-4-ol, methone, p-cymene, γ-terpinene and limonene), found that the oil fractionation enabled identification of other minor compounds not found in total oil such as norisoprenoides, alk-1-enes or chromolaenin. The essential oil showed antimicrobial potential on Escherichia coli, Salmonella enteritidis, Staphylococcus aureus and Bacillus cereus. On the other hand, no antibacterial activity of the oil was observed on Pseudomonas fluorescens and Lysteria monocytogenes, according to "Volatile Organic Compounds from Centaurium erythraea Rafn (Croatia) and the Antimicrobial Potential of Its Essential Oil" by Jerković I, Gašo-Sokač D, Pavlović H, Marijanović Z, Gugić M, Petrović I, Kovač S(2)
3. Skin tumorigenesis
In the investigation of the effects of limonene on the growth of 7,12-dimethylbenz[a]anthracene (DMBA)-initiated and 12-O-tetradecanoylphorbol-13-acetate (TPA)-promoted skin tumor development, found that -limonene (50 and 100 mg/kg body weight) treatments to the mouse skin significantly reduced the TPA-induced (a) edema and hyperplasia (p < 0.001); (b) expression of cyclooxygenase-2; (c) ornithine decarboxylase activity (p < 0.001); and (d) [(3)H] thymidine incorporation into DNA (p < 0.001), In addition, treatment of -limonene effectively restored the level of reduced glutathione, glutathione peroxidase, glutathione reductase, glutathione S-transferase, catalase and malondialdehyde production in TPA-treated mouse skin. In a two-stage skin tumorigenesis study, limonenesignificantly reduced the tumor burden (p < 0.005) and tumor incidence as compared to DMBA/TPA-treated mice. -Limonene treatment also extended the latency period of tumor development from 4 to 9 weeks. Limonene treatment decreased the expression level of Ras, Raf and phosphorylation of extracellular signal-regulated protein kinase 1/2 in DMBA/TPA-induced tumors.according to "D-Limonene modulates inflammation, oxidative stress and Ras-ERK pathway to inhibit murine skin tumorigenesis" by Chaudhary SC, Siddiqui MS, Athar M, Alam MS.(3)
4. Antihyperlipidemic Effects
In the investigation of the antihyperlipidemic activities of the essential oil from the leaves of Pinus koraiensis SIEB (EOPK) that has been used as a folk remedy for heart disease, found that
EOPK up-regulated low density lipoprotein receptor (LDLR) at the mRNA level as well as negatively suppressed the expression of sterol regulatory element-binding protein (SREBP)-1c, SREBP-2, 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMGCR), fatty acid synthase (FAS) and glycerol-3-phosphate acyltransferase (GPAT) involved in lipid metabolism in HepG2 cells. Also, western blotting showed that EOPK activated LDLR and attenuated the expression of FAS at the protein level in the cells. Consistently, EOPK significantly inhibited the level of human acylcoenzyme A: cholesterol acyltransferase (hACAT)1 and 2 and reduced the low-density lipoprotein (LDL) oxidation activity. Furthermore, chromatography-mass spectrometry (GC-MS) analysis showed that EOPK, an essential oil mixture, contained camphene (21.11%), d-limonene (21.01%), α-pinene (16.74%) and borneol (11.52%), according to "Essential Oil of Pinus koraiensis Leaves Exerts Antihyperlipidemic Effects via Up-regulation of Low-density Lipoprotein Receptor and Inhibition of Acyl-coenzyme A: Cholesterol Acyltransferase" by Kim JH, Lee HJ, Jeong SJ, Lee MH, Kim SH.(4)
5. Antioxidant effects
In the evaluation of evaluate the antioxidant capacity and the acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activity of the peel essential oils from three Citrus species, C. aurantifolia Swingle, C. aurantium L., and C. bergamia Risso & Poit, found that the demonstrated antioxidant activity and procholinesterase properties of Citrus essential oils suggested their use as a new potential source of natural antioxidant to added as extra-nutrient for using in food industries as a valuable new flavor with functional properties for food or nutraceutical products with particular relevance to supplements for the elderly, according to "Comparative study on the antioxidant capacity and cholinesterase inhibitory activity of Citrus aurantifolia Swingle, C. aurantium L., and C. bergamia Risso and Poit. peel essential oils" by Tundis R, Loizzo MR, Bonesi M, Menichini F, Mastellone V, Colica C, Menichini F.(5)
6. Anti cancers
In the review attempted to collect all available published scientific literature of eight naturally occurring terpenoids and their effect on inhibition of tumor progression, found that literature survey revealed that triterpenoids, such as glycyrrhizic acid, ursolic acid, oleanolic acid, and nomilin, the diterpene andrographolide, and the monoterpenoids like limonene and perillic acid had shown immunomodulatory and antitumor activities. All of them could induce apoptosis in various cancer cells by activating various proapoptotic signaling cascades. Many of these terpenoids found to inhibit metastatic progression and tumor-induced angiogenesis, according to "Inhibition of tumor progression by naturally occurring terpenoids" by Kuttan G, Pratheeshkumar P, Manu KA, Kuttan R.(6)
7. Antigenotoxic properties
In the evaluation of the chemical composition and the DNA protective effect of the essential oils (EOs) from Lippia alba against bleomycin-induced genotoxicity, found that the EOs were not genotoxic in the SOS chromotest, but one of the major compound (limonene) showed genotoxicity at doses between 97 and 1549 mM. Both EOs protected bacterial cells against bleomycin-induced genotoxicity. Antigenotoxicity in the two L. alba chemotypes was related to the major compounds, citral and carvone, respectively. The results were discussed in relation to the chemopreventive potential of L. alba EOs and its major compounds, according to "Chemical composition and antigenotoxic properties of Lippia alba essential oils" by López MA, Stashenko EE, Fuentes JL.(7)
8. Microbial Effects
In the assessment of the composition of hydro-distilled and SC-CO(2) extracted oils. Nineteen constituents, which accounted for 89.32% of total constituents in HD oil, represented by limonene (4.31%), (Z)-β-ocimene (3.69%), terpinolene (22.24%), neryl acetate (36.19%), nerol (9.51%) and p-cymene-8-ol (2.61%) were identified. In SC-CO(2) extracted oil, 24 constituents representing 89.95% of total constituents were identified. Terpinolene (5.08%), germacrene D (2.17%), neryl acetate (51.62%), nerol (9.78%), geranyl acetate (2.06%), α-bisabolol (2.48%) and 1-nonadecanol (4.96%) were the dominating constituents anf their anti microbial effects, found that the oil exhibited moderate to high antimicrobial activity against fungi C. albicans (MIC 625 µg ml(-1)), A. parasiticus (MIC 312.5 µg ml(-1)), A. sydowii (MIC 312.5 µg ml(-1)), T. rubrum (MIC 625 µg ml(-1)), Gram-positive bacteria B. subtilis (MIC 625 µg ml(-1)) and Gram-negative bacteria P. aeruginosa (MIC 312.5 µg ml(-1)), according to "Composition and antimicrobial activity of the essential oil of Heracleum thomsonii (Clarke) from the cold desert of the western Himalayas" by Guleria S, Saini R, Jaitak V, Kaul VK, Lal B, Rahi P, Gulati A, Singh B.(8)
9. Antioxidant and anticarcinogenic effects
In the evaluation of the efficacy of fennel seed methanolic extract (FSME), such as flavonoids, terpenoids, alkaloids, phenols, and sterols; estragole (71.099%), gallic acid (18.895%), and L-limonene was the most prevalent monoterpene hydrocarbon (11.967%). for its antioxidant, cytotoxic, and antitumor activities and for its capacity to serve as a nontoxic radioprotector in Swiss albino mice, found that FSME may have remarkable anticancer potential against a breast cancer cell line (MCF7) and liver cancer cell line (Hepg-2). It also showed strong free radical-scavenging activity (100%). Thus, FSME may reduce oxidative stress and protect mouse cells from damage caused by reactive oxygen species. In addition, it could be used as a safe, effective, and easily accessible source of natural antioxidants to improve the oxidative stability of fatty foods during storage. FSME also exhibited an antitumor effect by modulating lipid peroxidation and augmenting the antioxidant defense system in EAC-bearing mice with or without exposure to radiation, according to "Antioxidant and anticarcinogenic effects of methanolic extract and volatile oil of fennel seeds (Foeniculum vulgare)" by Mohamad RH, El-Bastawesy AM, Abdel-Monem MG, Noor AM, Al-Mehdar HA, Sharawy SM, El-Merzabani MM.(9)
10. DNA protection and Anti tumors
In the assessment of the nutraceutical value of orange and lemon juices as well as two of their active compounds: hesperidin and limonene performed at three levels to evaluate different biological health promoter activities, found that Life-span experiments revealed that the lower concentrations of orange juice, hesperidin, andlimonene exerted a positive influence on the life span of Drosophila. Finally all substances showed cytotoxic activity, with hesperidin being least active. Taking into account the safety, antigenotoxicity, longevity, and cytotoxicity data obtained in the different assays, orange juice may be a candidate as a nutraceutical food as it (1) is not genotoxic, (2) is able to protect DNA against free radicals, and (3) inhibits growth of tumor cells, according to "Role of citrus juices and distinctive components in the modulation of degenerative processes: genotoxicity, antigenotoxicity, cytotoxicity, and longevity in Drosophila" by Fernández-Bedmar Z, Anter J, de La Cruz-Ares S, Muñoz-Serrano A, Alonso-Moraga A, Pérez-Guisado J.(10)
Etc.
Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/20625233
(2) http://www.ncbi.nlm.nih.gov/pubmed/22349896
(3) http://www.ncbi.nlm.nih.gov/pubmed/22318307
(4) http://www.ncbi.nlm.nih.gov/pubmed/22275303
(5) http://www.ncbi.nlm.nih.gov/pubmed/22260108
(6) http://www.ncbi.nlm.nih.gov/pubmed/21936626
(7) http://www.ncbi.nlm.nih.gov/pubmed/21931523
(8) http://www.ncbi.nlm.nih.gov/pubmed/21854172
(9) http://www.ncbi.nlm.nih.gov/pubmed/21812646
(10) http://www.ncbi.nlm.nih.gov/pubmed/21707429
Traditional Chinese Medicine Herbal Therapy - Popular Chinese Herbs – Bei Mu (Bulbus Fritillariae Cirrhosae)
Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Bei Mu (Bulbus Fritillariae Cirrhosae)
Bei Mu is also known as Fritillary Bulb. The sweet, bitter and cold herb has been used in TCM as antibiotic and to raise blood pressure, stop cough, , increased blood sugar,etc. as it transforms Phlegm, calms cough; clears Heat, dissolves nodules, etc. by enhancing the functions of heart and lung channels.
Ingredients
1. Chinpeimine
2. Sonpeimine
3. Fritimine
4. Sipemine
5. Songbeisine
6. 26-Imino-17
7. 23beta-oxido-5alpha-jerv-12-en-11-oxo-3beta-ol
8. Minpeimine,
9. Minpeiminine
10. Imperialine,
11. Delavine
12. Delavinone
13. Chuanbeinone
14. Dalafrinone
15. Dalafrine Solanid-5-enine-3beta
16. 5alpha, 6beta-triol
17. Beilupeimine
18. Fritiminine
19. Etc.
Health Benefits
1. Antitussive, expectorant and anti-inflammatory
alkaloids imperialine, chuanbeinone, verticinone and verticine isolated, have exerted the enhancement as imperialine(I), verticinone(III) and verticine(IV) have enhanced mice’s tracheal phenol red output in expectorant evaluation, and imperialine(I), chuanbeinone(II) significantly inhibited the development of ear edema in a dose-dependent manner in anti-inflammatory assessment, according to the study of “Antitussive, expectorant and anti-inflammatory alkaloids from Bulbus Fritillariae Cirrhosae” by Wang D, Zhu J, Wang S, Wang X, Ou Y, Wei D, Li X.(1).
2. Allergically reaction
Fritillaria ussuriensis (FU, derived from the bulbs of various species of the genus Fritillaria, including Fritillaria thunbergii Miq) has shown significant inhibition of mast-cell accumulation in ear tissue at the chronic phase. These results indicate that it inhibits allergic reactions, according to the study of “Fritillaria ussuriensis extract inhibits the production of inflammatory cytokine and MAPKs in mast cells” by Cho IH, Lee MJ, Kim JH, Han NY, Shin KW, Sohn Y, Jung HS.(2).
3. Anti-Helicobacter pylori
Ethanol extracts of Fritillaria thunbergii (Liliaceae) in 30 Chinese herbal medicines has exerted the ability inhibitory against all the six Helicobacter pylori strains (MICs: approximately 60 microg/ml), according to the study of “In vitro anti-Helicobacter pylori action of 30 Chinese herbal medicines used to treat ulcer diseases” by Li Y, Xu C, Zhang Q, Liu JY, Tan RX.(3).
4. etc.
Side effects
1. Raw Bei Mu is toxic and not for internal use.
2. Do not use Bei mu if you are pregnant or breast feeding without consulting with related field specialist.
3. Do not take Bei mu if you have high blood pressure.
4. Etc.
Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/21958967
(2) http://www.ncbi.nlm.nih.gov/pubmed/21821956
(3) http://www.ncbi.nlm.nih.gov/pubmed/15814268
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Bei Mu (Bulbus Fritillariae Cirrhosae)
Bei Mu is also known as Fritillary Bulb. The sweet, bitter and cold herb has been used in TCM as antibiotic and to raise blood pressure, stop cough, , increased blood sugar,etc. as it transforms Phlegm, calms cough; clears Heat, dissolves nodules, etc. by enhancing the functions of heart and lung channels.
Ingredients
1. Chinpeimine
2. Sonpeimine
3. Fritimine
4. Sipemine
5. Songbeisine
6. 26-Imino-17
7. 23beta-oxido-5alpha-jerv-12-en-11-oxo-3beta-ol
8. Minpeimine,
9. Minpeiminine
10. Imperialine,
11. Delavine
12. Delavinone
13. Chuanbeinone
14. Dalafrinone
15. Dalafrine Solanid-5-enine-3beta
16. 5alpha, 6beta-triol
17. Beilupeimine
18. Fritiminine
19. Etc.
Health Benefits
1. Antitussive, expectorant and anti-inflammatory
alkaloids imperialine, chuanbeinone, verticinone and verticine isolated, have exerted the enhancement as imperialine(I), verticinone(III) and verticine(IV) have enhanced mice’s tracheal phenol red output in expectorant evaluation, and imperialine(I), chuanbeinone(II) significantly inhibited the development of ear edema in a dose-dependent manner in anti-inflammatory assessment, according to the study of “Antitussive, expectorant and anti-inflammatory alkaloids from Bulbus Fritillariae Cirrhosae” by Wang D, Zhu J, Wang S, Wang X, Ou Y, Wei D, Li X.(1).
2. Allergically reaction
Fritillaria ussuriensis (FU, derived from the bulbs of various species of the genus Fritillaria, including Fritillaria thunbergii Miq) has shown significant inhibition of mast-cell accumulation in ear tissue at the chronic phase. These results indicate that it inhibits allergic reactions, according to the study of “Fritillaria ussuriensis extract inhibits the production of inflammatory cytokine and MAPKs in mast cells” by Cho IH, Lee MJ, Kim JH, Han NY, Shin KW, Sohn Y, Jung HS.(2).
3. Anti-Helicobacter pylori
Ethanol extracts of Fritillaria thunbergii (Liliaceae) in 30 Chinese herbal medicines has exerted the ability inhibitory against all the six Helicobacter pylori strains (MICs: approximately 60 microg/ml), according to the study of “In vitro anti-Helicobacter pylori action of 30 Chinese herbal medicines used to treat ulcer diseases” by Li Y, Xu C, Zhang Q, Liu JY, Tan RX.(3).
4. etc.
Side effects
1. Raw Bei Mu is toxic and not for internal use.
2. Do not use Bei mu if you are pregnant or breast feeding without consulting with related field specialist.
3. Do not take Bei mu if you have high blood pressure.
4. Etc.
Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/21958967
(2) http://www.ncbi.nlm.nih.gov/pubmed/21821956
(3) http://www.ncbi.nlm.nih.gov/pubmed/15814268
Most Common Disease of 50plus: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Polymyalgia Arthritis (Rheumatica) Treatment: The Individual herb - Bromelain
Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Musculoskeletal disorders (MSDs) are medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed(1).
Types of Musculo-Skeletal disorders in elder(2)
1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalgia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia
Polymyalgia Arthritis (Rheumatica)
Polymalgia Arthritis is defined as a condition a common inflammatory rheumatic disease which causes pain, stiffness and tenderness in large muscles, including muscles shoulders and pelvic girdle as a result of the presence of a synovitis in proximal joints and periarticular structures.
Treatments
B.2. Herbal and Traditional Chinese medicine
Herbal medicine from different cultures have been found effectively in reduced symptoms and treatment for patient with Polymyalagia Arthritis (Rheumatica), including
B.2.1. The Individual herbs
8. Bromelain
Bromelain, a group of protein digesting enzymes found in pineapples (Ananas comosus) has been used in traditional medicine as inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.(467,223). The herbal medicine may be used as valuable and safe alternative to NSAIDs in patients suffering acute and chronic Arthritis from degenerative joint diseases due to its anti-inflammatory and analgesic effects(468,224).
According to the Rehabilitation Centre for Cardiovascular and Rheumatic Diseases, oral enzyme therapy (Phlogenzym-(PE)), has found effectively in treatment for patient with arthritis with high levels of pain due to signs of inflammation(469,225).
Dr. Brien S and the research team in the study of the anti-inflammatory and analgesic properties in patient with arthritis said that more studies and trials are necessary to trials to establish the efficacy and optimum dosage for bromelain as a safer alternative or adjunctive treatment for arthritis(470,226).
Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
References
(467,223) Popular #Herbs - Bromelain by Kyle J. Norton
(468,224) A complex of three natural anti-inflammatory agents provides relief of osteoarthritis pain by Conrozier T, Mathieu P, Bonjean M, Marc JF, Renevier JL, Balblanc JC.(PubMed)
(469,225) Efficacy and tolerance of an oral enzyme combination in painful osteoarthritis of the hip. A double-blind, randomised study comparing oral enzymes with non-steroidal anti-inflammatory drugs by Klein G1, Kullich W, Schnitker J, Schwann H.(PubMed)
(470,226) Bromelain as a Treatment for Osteoarthritis: a Review of Clinical Studies by Brien S, Lewith G, Walker A, Hicks SM, Middleton D.(PubMed)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Types of Musculo-Skeletal disorders in elder(2)
1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalgia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia
Polymyalgia Arthritis (Rheumatica)
Polymalgia Arthritis is defined as a condition a common inflammatory rheumatic disease which causes pain, stiffness and tenderness in large muscles, including muscles shoulders and pelvic girdle as a result of the presence of a synovitis in proximal joints and periarticular structures.
Treatments
B.2. Herbal and Traditional Chinese medicine
Herbal medicine from different cultures have been found effectively in reduced symptoms and treatment for patient with Polymyalagia Arthritis (Rheumatica), including
B.2.1. The Individual herbs
8. Bromelain
Bromelain, a group of protein digesting enzymes found in pineapples (Ananas comosus) has been used in traditional medicine as inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.(467,223). The herbal medicine may be used as valuable and safe alternative to NSAIDs in patients suffering acute and chronic Arthritis from degenerative joint diseases due to its anti-inflammatory and analgesic effects(468,224).
According to the Rehabilitation Centre for Cardiovascular and Rheumatic Diseases, oral enzyme therapy (Phlogenzym-(PE)), has found effectively in treatment for patient with arthritis with high levels of pain due to signs of inflammation(469,225).
Dr. Brien S and the research team in the study of the anti-inflammatory and analgesic properties in patient with arthritis said that more studies and trials are necessary to trials to establish the efficacy and optimum dosage for bromelain as a safer alternative or adjunctive treatment for arthritis(470,226).
Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
References
(467,223) Popular #Herbs - Bromelain by Kyle J. Norton
(468,224) A complex of three natural anti-inflammatory agents provides relief of osteoarthritis pain by Conrozier T, Mathieu P, Bonjean M, Marc JF, Renevier JL, Balblanc JC.(PubMed)
(469,225) Efficacy and tolerance of an oral enzyme combination in painful osteoarthritis of the hip. A double-blind, randomised study comparing oral enzymes with non-steroidal anti-inflammatory drugs by Klein G1, Kullich W, Schnitker J, Schwann H.(PubMed)
(470,226) Bromelain as a Treatment for Osteoarthritis: a Review of Clinical Studies by Brien S, Lewith G, Walker A, Hicks SM, Middleton D.(PubMed)
The Holistic prevention, management and treatment of Polycystic Ovarian Syndrome: The fertility Herb Black Cohosh
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Polycystic Ovarian Syndrome
Polycystic Ovarian Syndrome is defined as endocrinologic diseases among reproductive-age women caused by undeveloped follicles clumping on the ovaries that interferes with the function of the normal ovaries associated with a high risk for metabolic disorder(1) as resulting of enlarged ovaries(2), leading to hormone imbalance(excessive androgen and anti-müllerian hormone (AMH) )(1)(3)(4)(5), induced Hirsutism(6)(7), reproductive disorder(10(12)), risks of type 2 diabetes(9)(10)(11), metabolic syndrome(10)(12) and early cardiovascular disease(8)(13), acne(10)(14), endometrial cancer(18)(19),weight gain and obesity(15)(16)(17). The syndrome effects over 5% of women population or 1 in 20 women.
Unfortunately, according to studies, women with PCOs after the reproductive age, are associated to continuously increase risk of type II diabetes, with no increasingaltered glucose tolerance(20), CVD and hypertension(21).
The prevention and management In Herbal Medicine
Polycystic ovary syndrome (PCOS) is unpreventable in Western medicine. Early diagnosis and treatment may reduce risk of its complications, including infertility, metabolic syndrome, obesity, diabetes, cardiovascular diseases, stroke, etc.
Reduce fat intake less than 30% of total calories with a low proportion of saturated fat and high in fiber from predominantly low-glycaemic-index-carbohydrate foods for patients with PCOs(827a). Calorie intake should be distributed between several meals per day with restricted intake of snacks and drinks(828).
The Fertility Herb: Black cohosh
Black cohosh is a glabrous herbaceous perennial plant, producing large, compound leaves from an underground rhizome and belongs to the family Ranunculaceae used in traditional medicine in treating symptoms of all kinds of gynaecological problems(905), including symptoms of premenstrual tension(907) and menopause(906)
1. Phytoestrogen
Phytoestrogen found it balck cohosh showed to occupy the estrogen receptor sites in women body(908), through it antiestrogenic and extrogenic effects(909), to induce hormone balancing may result in improving the chance of ovulation and fertility(910)(911).
2. Immunity
Black cohosh processes anti inflammatory(913)(914) and anti oxidant(914) effect through enhancing immune system fighting against microbial(915)(916) invasion and irregular cell growth(917)(918) and other inflammatory diseases(913). According to School of Medicine, Wuhan University black cohosh may be beneficiary for patient with patients with coronary heart disease, atherosclerosis, pulmonary heart disease and thrombosis throught its anti inflammatory effects(912).
3. Metabolic Syndrome
In rat model study, black cohosh and its triterpene-saponins showed to reduce high load with fat tissue in the PFD and in the knee joints, body weight, serum leptin and cholesterol and glucose levels caused by metabolic syndrome, according to University Medical Center Göttingen(919). The consumption of black cohost also effectively decreases enhanced pituitary LH secretion, attenuates body weight gain, plasma lipids and intra-abdominal fat (IAF) accumulation, lowers FPI and has no effects on uterine mass(920).
4. Fertility
Use conjunction with clomiphene citrate, black cohosh induced endometrial thickness, serum progesterone and clinical pregnancy rate and cycle outcomes in some infertile couples(921). According to Assiut University, in the differentiation of relatively low pregnancy rates in CC induction cycles of clomiphene citrate in infertile couple, follicular-phase supplements imicifuga racemosa or ethinyl oestradiol needed significantly fewer days for adequate follicular maturation, had a thicker endometrium and higher oestradiol concentration at the time of human chorionic gonadotrophin injection with better outcome of pregnancy rate(922)(923).
5. Condense Tannins
It also contains condense tannin, a type of proanthocyanidin which has been used as nutritional and therapeutic supplements in Europe in promoting the function of flavonoids as an antioxdant(924)(925) to improve Immunity(926)(927) against auto immune response induced infertility(962)(933) and microbial invasion(928)(929), but also maintain DNA integrity about irregular cell growth(930)(931).
6. Nervous Symptoms
Back cohost is said to contain chemical agent to bind the activities to serotonin receptors(939) in decreasing the risk of depression(936), anxiety(934), sleep problem(935) and emotional and physical stress(937)induced risk of infertility(938).
Side effects
1. Common side effects include
In high doses of black cohosh may cause abdominal pain, diarrhea, dizziness, headaches, joint pains, nausea, slow heart rate, tremors, visual dimness, vomiting, and weight gain, according to
University of Maryland Medical Center(941)(943)
2. Liver damage
Over dose of back cohosh may cause liver damage(940).
3. Digestive system
Over dose may cause occasional gastrointestinal discomfort, such as diarrhea; nausea and vomiting. sweating; constipation(942).
4. Etc.
Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
References
(1) Adiposity and metabolic dysfunction in polycystic ovary syndrome by Sam S.(PubMed)
(2) A "kiss" before conception: triggering ovulation with kisspeptin-54 may improve IVF by Young SL.(PubMed)
(3.) Androgen hyperfunction and excessive heterosexual hair growth in women, with special attention to the polycystic ovarian syndrome by Lunde O1.(PubMed)
(4) Expression of anti-Müllerian hormone in letrozole rat model of polycystic ovary syndrome by Du DF1, Li XL, Fang F, Du MR.(PubMed)
(5) [Serum levels of anti-muller hormone in women with polycystic ovary syndromeand healthy women of reproductive age].[Article in Bulgarian] by Parahuleva N, Pehlivanov B, Orbecova M, Deneva T, Uchikova E.(PubMed)
(6) [Current opinions on the etiology and pathophysiology of hirsutism].[Article in Polish] by Krysiak R1, Kedzia A, Okopień B.(PubMed)
(7) The clinical evaluation of hirsutism by Somani N1, Harrison S, Bergfeld WF.(PubMed)
(8) Polycystic ovary syndrome and insulin: our understanding in the past, present and future by Mayer SB1, Evans WS, Nestler JE.(PubMed)
(9) Association of mean platelet volume with androgens and insulin resistance in nonobese patients with polycystic ovary syndrome by Dogan BA1, Arduc A2, Tuna MM1, Karakılıc E1, Dagdelen I1, Tutuncu Y1, Berker D1, Guler S1.(PubMed)
(10) Approach to the patient: contraception in women with polycystic ovary syndrome by Yildiz BO1.(PubMed)
(11) Polycystic ovarian syndrome (PCOS): a significant contributor to the overall burden of type 2 diabetes in women by Talbott EO1, Zborowski JV, Rager JR, Kip KE, Xu X, Orchard TJ.(PubMed)
(12) Prevalence of vitamin D deficiency in Slovak women with polycystic ovary syndrome and its relation to metabolic and reproductive abnormalities by Figurová J1, Dravecká I, Javorský M, Petríková J, Lazúrová I.(PubMed)
(13) Role of Insulin Sensitizers on Cardiovascular Risk Factors in Polycystic Ovarian Syndrome: A Meta-Analysis by Thethi TK1, Katalenich B2, Nagireddy P3, Chabbra P4, Kuhadiya N5, Fonseca V1.(PubMed)
(14) Acne in hirsute women by Lumezi BG1, Pupovci HL1, Berisha VL1, Goçi AU2, Gerqari A3.(PubMed)
(15) Obesity and polycystic ovary syndrome by Naderpoor N1, Shorakae S, Joham A, Boyle J, De Courten B, Teede HJ.(PubMed)
(16) Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan by Teede H1, Deeks A, Moran L.(PubMed)
(17) Metabolic Evidence of Diminished Lipid Oxidation in Women With Polycystic Ovary Syndrome. by Whigham LD1, Butz DE2, Dashti H3, Tonelli M3, Johnson LK1, Cook ME2, Porter WP4, Eghbalnia HR5, Markley JL6, Lindheim SR7, Schoeller DA8, Abbott DH9, Assadi-Porter FM10.(PubMed)
(18) Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis by Barry JA1, Azizia MM1, Hardiman PJ2.(PubMed)
(19) Risk of cancer among women with polycystic ovary syndrome: a Danish cohort study by Gottschau M1, Kjaer SK2, Jensen A1, Munk C1, Mellemkjaer L3.(PubMed)
(20) Polycystic ovary syndrome: metabolic consequences and long-term management by Carmina E1.(PubMed)
(21) Arterial stiffness is increased in asymptomatic nondiabetic postmenopausal women with a polycystic ovary syndrome phenotype by Armeni E1, Stamatelopoulos K, Rizos D, Georgiopoulos G, Kazani M, Kazani A, Kolyviras A, Stellos K, Panoulis K, Alexandrou A, Creatsa M, Papamichael C, Lambrinoudaki I.(PubMed)
(827a) Diet and nutrition in polycystic ovary syndrome (PCOS): pointers for nutritional management by Farshchi H, Rane A, Love A, Kennedy RL(PubMed)
(828) The optimal diet for women with polycystic ovary syndrome? by Marsh K, Brand-Miller J.(PubMed)
(905) Predny ML, De Angelis P, Chamberlain JL (2006). Black cohosh (Actaea racemosa): An annotated Bibliography. General Technical Report SRS–97(Department of Agriculture Forest Service, Southern Research Station). p. 99. Retrieved 2009-08-24.
(906) Black cohosh (Actaea/Cimicifuga racemosa): review of the clinical data for safety and efficacy in menopausal symptoms. by Mahady GB1.(PubMed)
(907) Research highlights from the UIC/NIH Center for Botanical Dietary Supplements Research for Women’s Health: Black cohosh from the field to the clinic by Norman R Farnsworth1 and Gail B. Mahady(PubMed)
(908) A phytoestrogen diarylheptanoid mediates estrogen receptor/Akt/glycogen synthase kinase 3β protein-dependent activation of the Wnt/β-catenin signaling pathway. by Bhukhai K1, Suksen K, Bhummaphan N, Janjorn K, Thongon N, Tantikanlayaporn D, Piyachaturawat P, Suksamrarn A, Chairoungdua A.(PubMed)
(909) Isoflavones: chemistry, analysis, functions and effects on health and cancer by Ko KP1.(PubMed)
(910) Adding the phytoestrogen Cimicifugae Racemosae to clomiphene induction cycles with timed intercourse in polycystic ovary syndrome improves cycle outcomes and pregnancy rates - a randomized trial by Shahin AY1, Mohammed SA.(PubMed)
(911) Supplementation of clomiphene citrate cycles with Cimicifuga racemosa or ethinyl oestradiol--a randomized trial by Shahin AY1, Ismail AM, Shaaban OM.(PubMed) (912) Pharmacological actions of sodium ferulate in cardiovascular system by Wang BH1, Ou-Yang JP.(PubMed)
(913) Aqueous extracts of Cimicifuga racemosa and phenolcarboxylic constituents inhibit production of proinflammatory cytokines in LPS-stimulated human wholeblood by Schmid D1, Woehs F, Svoboda M, Thalhammer T, Chiba P, Moeslinger T.(PubMed)
(914) Inhibition of inducible nitric oxide synthesis by Cimicifuga racemosa (Actaea racemosa, black cohosh) extracts in LPS-stimulated RAW 264.7 macrophages by Schmid D1, Gruber M, Woehs F, Prinz S, Etzlstorfer B, Prucker C, Fuzzati N, Kopp B, Moeslinger T.(PubMed)
(915) Triterpenoid glycoside from Cimicifuga racemosa by Lai GF1, Wang YF, Fan LM, Cao JX, Luo SD.(PubMed)
(916) Extracts of Canadian first nations medicinal plants, used as natural products, inhibit neisseria gonorrhoeae isolates with different antibiotic resistance profiles by Cybulska P1, Thakur SD, Foster BC, Scott IM, Leduc RI, Arnason JT, Dillon JA.(PubMed)
(917) Black cohosh (Cimicifuga racemosa [L.] Nutt.): safety and efficacy forcancer patients by Walji R1, Boon H, Guns E, Oneschuk D, Younus J.(PubMed)
(918) Black cohosh, hot flushes, and breast cancer by Merchant S1, Stebbing J2.(PubMed)
(919) Cimicifuga racemosa and its triterpene-saponins prevent the Metabolic Syndrome and deterioration of cartilage in the knee joint of ovariectomized rats by similar mechanisms by Seidlova-Wuttke D1, Eder N, Stahnke V, Kammann M, Stecher G, Haunschild J, Wessels JT, Wuttke W.(PubMed)
(920) Effects of black cohosh extract on body weight gain, intra-abdominal fat accumulation, plasma lipids and glucose tolerance in ovariectomized Sprague-Dawley rats by Rachoń D1, Vortherms T, Seidlová-Wuttke D, Wuttke W.(PubMed)
(921) Adding phytoestrogens to clomiphene induction in unexplained infertilitypatients--a randomized trial by Shahin AY1, Ismail AM, Zahran KM, Makhlouf AM.(PubMed)
(922) Supplementation of clomiphene citrate cycles with Cimicifuga racemosa or ethinyl oestradiol--a randomized trial by Shahin AY1, Ismail AM, Shaaban OM.(PubMed)
(923) Adding the phytoestrogen Cimicifugae Racemosae to clomiphene induction cycles with timed intercourse in polycystic ovary syndrome improves cycle outcomes and pregnancy rates - a randomized trial by Shahin AY1, Mohammed SA.(PubMed)
(924) Influence of grape seed proanthocyanidin extract in broiler chickens: effect on chicken coccidiosis and antioxidant status by Wang ML1, Suo X, Gu JH, Zhang WW, Fang Q, Wang X.(PubMed)
(925) The fruit extract of Berberis crataegina DC: exerts potent antioxidant activity and protects DNA integrity by Charehsaz M1, Sipahi H2, Celep E3, Üstündağ A4, Cemiloğlu Ülker Ö5, Duydu Y6, Aydın A7, Yesilada E8.(PubMed)
(926) Grape consumption supports immunity in animals and humans by Percival SS1.(PubMed)
(927) Effect of proanthocyanidin-rich extract from Pinus radiata bark on immune response of specific-pathogen-free White Leghorn chickens by Park IJ1, Cha SY, Kang M, So YS, Go HG, Mun SP, Ryu KS, Jang HK.(PubMed)
(928) Synergistic effect of proanthocyanidin on the bactericidal action of the photolysis of H2O2 ,by Ikai H1, Nakamura K, Kanno T, Shirato M, Meirelles L, Sasaki K, Niwano Y.(PubMed)
(929) Proanthocyanidin-rich extracts from cranberry fruit (Vaccinium macrocarpon Ait.) selectively inhibit the growth of human pathogenic fungi Candida spp. and Cryptococcus neoformans by Patel KD1, Scarano FJ, Kondo M, Hurta RA, Neto CC.(PubMed)
(930) Oligomeric proanthocyanidin complexes (OPC) exert anti-proliferative and pro-apoptotic effects on prostate cancer cells by Neuwirt H1, Arias MC, Puhr M, Hobisch A, Culig Z.(PubMed)
(931) The cytotoxic effects of a novel IH636 grape seed proanthocyanidin extract on cultured human cancer cells by Ye X1, Krohn RL, Liu W, Joshi SS, Kuszynski CA, McGinn TR, Bagchi M, Preuss HG, Stohs SJ, Bagchi D.(PubMed)
(932) Antisperm immunity and infertility by Lu JC1, Huang YF, Lu NQ.(PubMed)
(933) Immune infertility: towards a better understanding of sperm (auto)-immunity. The value of proteomic analysis by Bohring C1, Krause W.(PubMed)
(934) Randomized, double-blind, placebo-controlled trial of Cimicifuga racemosa (black cohosh) in women with anxiety disorder due to menopause by Amsterdam JD1, Yao Y, Mao JJ, Soeller I, Rockwell K, Shults J.(PubMed)
(935) Black cohosh (Cimicifuga racemosa) in tamoxifen-treated breast cancer patients with climacteric complaints - a prospective observational study by Rostock M1, Fischer J, Mumm A, Stammwitz U, Saller R, Bartsch HH.(PubMed)
(936) Black cohosh and fluoxetine in the treatment of postmenopausal symptoms: a prospective, randomized trial by Oktem M1, Eroglu D, Karahan HB, Taskintuna N, Kuscu E, Zeyneloglu HB.(PubMed)
(937) Black Cohosh and Chasteberry: Herbs Valued by Women for Centuries B Y J OSEPH L. M AYO , MD, FACOG
(938) Is infertility really associated with higher levels of mental distress in the female population? Results from the North-Trøndelag Health Study and the Medical Birth Registry of Norway by Biringer E1, Howard LM, Kessler U, Stewart R, Mykletun A.(PubMed)
(939) Metabolism of Nω -methylserotonin, a serotonergic constituent of black cohosh (Cimicifuga racemosa, L. (Nutt.)), by human liver microsomes by Nikolić D1, Li J, van Breemen RB.(PubMed)
(940) Mechanism of hepatotoxicity due to black cohosh (Cimicifuga racemosa): histological, immunohistochemical and electron microscopy analysis of two liverbiopsies with clinical correlation by Enbom ET1, Le MD2, Oesterich L3, Rutgers J4, French SW2.(PubMed)
(941)University of Maryland Medical Center((PubMed)
(942) [Efficacy and safety of Black cohosh (Actaea/Cimicifuga racemosa) in the treatment of vasomotor symptoms--review of clinical trials].[Article in Polish] by Kanadys WM1, Leszczyńska-Gorzelak B, Oleszczuk J.(PubMed)
(943) Black cohosh: an alternative therapy for menopause? by Mahady GB1, Fabricant D, Chadwick LR, Dietz B.(PubMed)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Polycystic Ovarian Syndrome
Unfortunately, according to studies, women with PCOs after the reproductive age, are associated to continuously increase risk of type II diabetes, with no increasingaltered glucose tolerance(20), CVD and hypertension(21).
The prevention and management In Herbal Medicine
Polycystic ovary syndrome (PCOS) is unpreventable in Western medicine. Early diagnosis and treatment may reduce risk of its complications, including infertility, metabolic syndrome, obesity, diabetes, cardiovascular diseases, stroke, etc.
Reduce fat intake less than 30% of total calories with a low proportion of saturated fat and high in fiber from predominantly low-glycaemic-index-carbohydrate foods for patients with PCOs(827a). Calorie intake should be distributed between several meals per day with restricted intake of snacks and drinks(828).
The Fertility Herb: Black cohosh
Black cohosh is a glabrous herbaceous perennial plant, producing large, compound leaves from an underground rhizome and belongs to the family Ranunculaceae used in traditional medicine in treating symptoms of all kinds of gynaecological problems(905), including symptoms of premenstrual tension(907) and menopause(906)
1. Phytoestrogen
Phytoestrogen found it balck cohosh showed to occupy the estrogen receptor sites in women body(908), through it antiestrogenic and extrogenic effects(909), to induce hormone balancing may result in improving the chance of ovulation and fertility(910)(911).
2. Immunity
Black cohosh processes anti inflammatory(913)(914) and anti oxidant(914) effect through enhancing immune system fighting against microbial(915)(916) invasion and irregular cell growth(917)(918) and other inflammatory diseases(913). According to School of Medicine, Wuhan University black cohosh may be beneficiary for patient with patients with coronary heart disease, atherosclerosis, pulmonary heart disease and thrombosis throught its anti inflammatory effects(912).
3. Metabolic Syndrome
In rat model study, black cohosh and its triterpene-saponins showed to reduce high load with fat tissue in the PFD and in the knee joints, body weight, serum leptin and cholesterol and glucose levels caused by metabolic syndrome, according to University Medical Center Göttingen(919). The consumption of black cohost also effectively decreases enhanced pituitary LH secretion, attenuates body weight gain, plasma lipids and intra-abdominal fat (IAF) accumulation, lowers FPI and has no effects on uterine mass(920).
4. Fertility
Use conjunction with clomiphene citrate, black cohosh induced endometrial thickness, serum progesterone and clinical pregnancy rate and cycle outcomes in some infertile couples(921). According to Assiut University, in the differentiation of relatively low pregnancy rates in CC induction cycles of clomiphene citrate in infertile couple, follicular-phase supplements imicifuga racemosa or ethinyl oestradiol needed significantly fewer days for adequate follicular maturation, had a thicker endometrium and higher oestradiol concentration at the time of human chorionic gonadotrophin injection with better outcome of pregnancy rate(922)(923).
5. Condense Tannins
It also contains condense tannin, a type of proanthocyanidin which has been used as nutritional and therapeutic supplements in Europe in promoting the function of flavonoids as an antioxdant(924)(925) to improve Immunity(926)(927) against auto immune response induced infertility(962)(933) and microbial invasion(928)(929), but also maintain DNA integrity about irregular cell growth(930)(931).
6. Nervous Symptoms
Back cohost is said to contain chemical agent to bind the activities to serotonin receptors(939) in decreasing the risk of depression(936), anxiety(934), sleep problem(935) and emotional and physical stress(937)induced risk of infertility(938).
Side effects
1. Common side effects include
In high doses of black cohosh may cause abdominal pain, diarrhea, dizziness, headaches, joint pains, nausea, slow heart rate, tremors, visual dimness, vomiting, and weight gain, according to
University of Maryland Medical Center(941)(943)
2. Liver damage
Over dose of back cohosh may cause liver damage(940).
3. Digestive system
Over dose may cause occasional gastrointestinal discomfort, such as diarrhea; nausea and vomiting. sweating; constipation(942).
4. Etc.
Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
References
(1) Adiposity and metabolic dysfunction in polycystic ovary syndrome by Sam S.(PubMed)
(2) A "kiss" before conception: triggering ovulation with kisspeptin-54 may improve IVF by Young SL.(PubMed)
(3.) Androgen hyperfunction and excessive heterosexual hair growth in women, with special attention to the polycystic ovarian syndrome by Lunde O1.(PubMed)
(4) Expression of anti-Müllerian hormone in letrozole rat model of polycystic ovary syndrome by Du DF1, Li XL, Fang F, Du MR.(PubMed)
(5) [Serum levels of anti-muller hormone in women with polycystic ovary syndromeand healthy women of reproductive age].[Article in Bulgarian] by Parahuleva N, Pehlivanov B, Orbecova M, Deneva T, Uchikova E.(PubMed)
(6) [Current opinions on the etiology and pathophysiology of hirsutism].[Article in Polish] by Krysiak R1, Kedzia A, Okopień B.(PubMed)
(7) The clinical evaluation of hirsutism by Somani N1, Harrison S, Bergfeld WF.(PubMed)
(8) Polycystic ovary syndrome and insulin: our understanding in the past, present and future by Mayer SB1, Evans WS, Nestler JE.(PubMed)
(9) Association of mean platelet volume with androgens and insulin resistance in nonobese patients with polycystic ovary syndrome by Dogan BA1, Arduc A2, Tuna MM1, Karakılıc E1, Dagdelen I1, Tutuncu Y1, Berker D1, Guler S1.(PubMed)
(10) Approach to the patient: contraception in women with polycystic ovary syndrome by Yildiz BO1.(PubMed)
(11) Polycystic ovarian syndrome (PCOS): a significant contributor to the overall burden of type 2 diabetes in women by Talbott EO1, Zborowski JV, Rager JR, Kip KE, Xu X, Orchard TJ.(PubMed)
(12) Prevalence of vitamin D deficiency in Slovak women with polycystic ovary syndrome and its relation to metabolic and reproductive abnormalities by Figurová J1, Dravecká I, Javorský M, Petríková J, Lazúrová I.(PubMed)
(13) Role of Insulin Sensitizers on Cardiovascular Risk Factors in Polycystic Ovarian Syndrome: A Meta-Analysis by Thethi TK1, Katalenich B2, Nagireddy P3, Chabbra P4, Kuhadiya N5, Fonseca V1.(PubMed)
(14) Acne in hirsute women by Lumezi BG1, Pupovci HL1, Berisha VL1, Goçi AU2, Gerqari A3.(PubMed)
(15) Obesity and polycystic ovary syndrome by Naderpoor N1, Shorakae S, Joham A, Boyle J, De Courten B, Teede HJ.(PubMed)
(16) Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan by Teede H1, Deeks A, Moran L.(PubMed)
(17) Metabolic Evidence of Diminished Lipid Oxidation in Women With Polycystic Ovary Syndrome. by Whigham LD1, Butz DE2, Dashti H3, Tonelli M3, Johnson LK1, Cook ME2, Porter WP4, Eghbalnia HR5, Markley JL6, Lindheim SR7, Schoeller DA8, Abbott DH9, Assadi-Porter FM10.(PubMed)
(18) Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis by Barry JA1, Azizia MM1, Hardiman PJ2.(PubMed)
(19) Risk of cancer among women with polycystic ovary syndrome: a Danish cohort study by Gottschau M1, Kjaer SK2, Jensen A1, Munk C1, Mellemkjaer L3.(PubMed)
(20) Polycystic ovary syndrome: metabolic consequences and long-term management by Carmina E1.(PubMed)
(21) Arterial stiffness is increased in asymptomatic nondiabetic postmenopausal women with a polycystic ovary syndrome phenotype by Armeni E1, Stamatelopoulos K, Rizos D, Georgiopoulos G, Kazani M, Kazani A, Kolyviras A, Stellos K, Panoulis K, Alexandrou A, Creatsa M, Papamichael C, Lambrinoudaki I.(PubMed)
(827a) Diet and nutrition in polycystic ovary syndrome (PCOS): pointers for nutritional management by Farshchi H, Rane A, Love A, Kennedy RL(PubMed)
(828) The optimal diet for women with polycystic ovary syndrome? by Marsh K, Brand-Miller J.(PubMed)
(905) Predny ML, De Angelis P, Chamberlain JL (2006). Black cohosh (Actaea racemosa): An annotated Bibliography. General Technical Report SRS–97(Department of Agriculture Forest Service, Southern Research Station). p. 99. Retrieved 2009-08-24.
(906) Black cohosh (Actaea/Cimicifuga racemosa): review of the clinical data for safety and efficacy in menopausal symptoms. by Mahady GB1.(PubMed)
(907) Research highlights from the UIC/NIH Center for Botanical Dietary Supplements Research for Women’s Health: Black cohosh from the field to the clinic by Norman R Farnsworth1 and Gail B. Mahady(PubMed)
(908) A phytoestrogen diarylheptanoid mediates estrogen receptor/Akt/glycogen synthase kinase 3β protein-dependent activation of the Wnt/β-catenin signaling pathway. by Bhukhai K1, Suksen K, Bhummaphan N, Janjorn K, Thongon N, Tantikanlayaporn D, Piyachaturawat P, Suksamrarn A, Chairoungdua A.(PubMed)
(909) Isoflavones: chemistry, analysis, functions and effects on health and cancer by Ko KP1.(PubMed)
(910) Adding the phytoestrogen Cimicifugae Racemosae to clomiphene induction cycles with timed intercourse in polycystic ovary syndrome improves cycle outcomes and pregnancy rates - a randomized trial by Shahin AY1, Mohammed SA.(PubMed)
(911) Supplementation of clomiphene citrate cycles with Cimicifuga racemosa or ethinyl oestradiol--a randomized trial by Shahin AY1, Ismail AM, Shaaban OM.(PubMed) (912) Pharmacological actions of sodium ferulate in cardiovascular system by Wang BH1, Ou-Yang JP.(PubMed)
(913) Aqueous extracts of Cimicifuga racemosa and phenolcarboxylic constituents inhibit production of proinflammatory cytokines in LPS-stimulated human wholeblood by Schmid D1, Woehs F, Svoboda M, Thalhammer T, Chiba P, Moeslinger T.(PubMed)
(914) Inhibition of inducible nitric oxide synthesis by Cimicifuga racemosa (Actaea racemosa, black cohosh) extracts in LPS-stimulated RAW 264.7 macrophages by Schmid D1, Gruber M, Woehs F, Prinz S, Etzlstorfer B, Prucker C, Fuzzati N, Kopp B, Moeslinger T.(PubMed)
(915) Triterpenoid glycoside from Cimicifuga racemosa by Lai GF1, Wang YF, Fan LM, Cao JX, Luo SD.(PubMed)
(916) Extracts of Canadian first nations medicinal plants, used as natural products, inhibit neisseria gonorrhoeae isolates with different antibiotic resistance profiles by Cybulska P1, Thakur SD, Foster BC, Scott IM, Leduc RI, Arnason JT, Dillon JA.(PubMed)
(917) Black cohosh (Cimicifuga racemosa [L.] Nutt.): safety and efficacy forcancer patients by Walji R1, Boon H, Guns E, Oneschuk D, Younus J.(PubMed)
(918) Black cohosh, hot flushes, and breast cancer by Merchant S1, Stebbing J2.(PubMed)
(919) Cimicifuga racemosa and its triterpene-saponins prevent the Metabolic Syndrome and deterioration of cartilage in the knee joint of ovariectomized rats by similar mechanisms by Seidlova-Wuttke D1, Eder N, Stahnke V, Kammann M, Stecher G, Haunschild J, Wessels JT, Wuttke W.(PubMed)
(920) Effects of black cohosh extract on body weight gain, intra-abdominal fat accumulation, plasma lipids and glucose tolerance in ovariectomized Sprague-Dawley rats by Rachoń D1, Vortherms T, Seidlová-Wuttke D, Wuttke W.(PubMed)
(921) Adding phytoestrogens to clomiphene induction in unexplained infertilitypatients--a randomized trial by Shahin AY1, Ismail AM, Zahran KM, Makhlouf AM.(PubMed)
(922) Supplementation of clomiphene citrate cycles with Cimicifuga racemosa or ethinyl oestradiol--a randomized trial by Shahin AY1, Ismail AM, Shaaban OM.(PubMed)
(923) Adding the phytoestrogen Cimicifugae Racemosae to clomiphene induction cycles with timed intercourse in polycystic ovary syndrome improves cycle outcomes and pregnancy rates - a randomized trial by Shahin AY1, Mohammed SA.(PubMed)
(924) Influence of grape seed proanthocyanidin extract in broiler chickens: effect on chicken coccidiosis and antioxidant status by Wang ML1, Suo X, Gu JH, Zhang WW, Fang Q, Wang X.(PubMed)
(925) The fruit extract of Berberis crataegina DC: exerts potent antioxidant activity and protects DNA integrity by Charehsaz M1, Sipahi H2, Celep E3, Üstündağ A4, Cemiloğlu Ülker Ö5, Duydu Y6, Aydın A7, Yesilada E8.(PubMed)
(926) Grape consumption supports immunity in animals and humans by Percival SS1.(PubMed)
(927) Effect of proanthocyanidin-rich extract from Pinus radiata bark on immune response of specific-pathogen-free White Leghorn chickens by Park IJ1, Cha SY, Kang M, So YS, Go HG, Mun SP, Ryu KS, Jang HK.(PubMed)
(928) Synergistic effect of proanthocyanidin on the bactericidal action of the photolysis of H2O2 ,by Ikai H1, Nakamura K, Kanno T, Shirato M, Meirelles L, Sasaki K, Niwano Y.(PubMed)
(929) Proanthocyanidin-rich extracts from cranberry fruit (Vaccinium macrocarpon Ait.) selectively inhibit the growth of human pathogenic fungi Candida spp. and Cryptococcus neoformans by Patel KD1, Scarano FJ, Kondo M, Hurta RA, Neto CC.(PubMed)
(930) Oligomeric proanthocyanidin complexes (OPC) exert anti-proliferative and pro-apoptotic effects on prostate cancer cells by Neuwirt H1, Arias MC, Puhr M, Hobisch A, Culig Z.(PubMed)
(931) The cytotoxic effects of a novel IH636 grape seed proanthocyanidin extract on cultured human cancer cells by Ye X1, Krohn RL, Liu W, Joshi SS, Kuszynski CA, McGinn TR, Bagchi M, Preuss HG, Stohs SJ, Bagchi D.(PubMed)
(932) Antisperm immunity and infertility by Lu JC1, Huang YF, Lu NQ.(PubMed)
(933) Immune infertility: towards a better understanding of sperm (auto)-immunity. The value of proteomic analysis by Bohring C1, Krause W.(PubMed)
(934) Randomized, double-blind, placebo-controlled trial of Cimicifuga racemosa (black cohosh) in women with anxiety disorder due to menopause by Amsterdam JD1, Yao Y, Mao JJ, Soeller I, Rockwell K, Shults J.(PubMed)
(935) Black cohosh (Cimicifuga racemosa) in tamoxifen-treated breast cancer patients with climacteric complaints - a prospective observational study by Rostock M1, Fischer J, Mumm A, Stammwitz U, Saller R, Bartsch HH.(PubMed)
(936) Black cohosh and fluoxetine in the treatment of postmenopausal symptoms: a prospective, randomized trial by Oktem M1, Eroglu D, Karahan HB, Taskintuna N, Kuscu E, Zeyneloglu HB.(PubMed)
(937) Black Cohosh and Chasteberry: Herbs Valued by Women for Centuries B Y J OSEPH L. M AYO , MD, FACOG
(938) Is infertility really associated with higher levels of mental distress in the female population? Results from the North-Trøndelag Health Study and the Medical Birth Registry of Norway by Biringer E1, Howard LM, Kessler U, Stewart R, Mykletun A.(PubMed)
(939) Metabolism of Nω -methylserotonin, a serotonergic constituent of black cohosh (Cimicifuga racemosa, L. (Nutt.)), by human liver microsomes by Nikolić D1, Li J, van Breemen RB.(PubMed)
(940) Mechanism of hepatotoxicity due to black cohosh (Cimicifuga racemosa): histological, immunohistochemical and electron microscopy analysis of two liverbiopsies with clinical correlation by Enbom ET1, Le MD2, Oesterich L3, Rutgers J4, French SW2.(PubMed)
(941)University of Maryland Medical Center((PubMed)
(942) [Efficacy and safety of Black cohosh (Actaea/Cimicifuga racemosa) in the treatment of vasomotor symptoms--review of clinical trials].[Article in Polish] by Kanadys WM1, Leszczyńska-Gorzelak B, Oleszczuk J.(PubMed)
(943) Black cohosh: an alternative therapy for menopause? by Mahady GB1, Fabricant D, Chadwick LR, Dietz B.(PubMed)
The Obesity's Weight Loss Recipes: The Weepy salad
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Recipe attributed to Company's Coming Salads by Jean Pare
This onion really do weep which helps moisten the whole salad
Head lettuce, In small chunks 1
Salad dressing ( or mayonnaise) 1/2 to 1 cup (125 to 250 ml)
Red onion ( or white), sliced very thinly 1
Granulated sugar 1tbsp. (15ml)
Cooked peas. fresh or frozen 11/2 cup (375 ml)
Swiss cheese, cut into strip 11/2 cup (375 ml)
Bacon sliced, cooked and crumbled 6
Place1/3 lettuce chunks in bottom of bowl. Spread a few spoons of salad dressing over top. Layer 1'3 onion slices over top. Sprinkle lightly with sugar, about 1 tsp. (5 ml). Sugar all the onion as this causes them to weep. Put on 1/3 peas by cheese. Repeat layers twice. Cover and chill for 2 to 3 hours
Before serving, sprinkle bacon over top. Do not toss. Serve 12.
Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Recipe attributed to Company's Coming Salads by Jean Pare
This onion really do weep which helps moisten the whole salad
Head lettuce, In small chunks 1
Salad dressing ( or mayonnaise) 1/2 to 1 cup (125 to 250 ml)
Red onion ( or white), sliced very thinly 1
Granulated sugar 1tbsp. (15ml)
Cooked peas. fresh or frozen 11/2 cup (375 ml)
Swiss cheese, cut into strip 11/2 cup (375 ml)
Bacon sliced, cooked and crumbled 6
Place1/3 lettuce chunks in bottom of bowl. Spread a few spoons of salad dressing over top. Layer 1'3 onion slices over top. Sprinkle lightly with sugar, about 1 tsp. (5 ml). Sugar all the onion as this causes them to weep. Put on 1/3 peas by cheese. Repeat layers twice. Cover and chill for 2 to 3 hours
Before serving, sprinkle bacon over top. Do not toss. Serve 12.
Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Obesity and Obesity's complication - The association of Obesity on Impotence
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Obesity is a medical condition of excess body fat accumulated overtime, while overweight is a condition of excess body weight relatively to the height. According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered over weight, while a BMI of over 30 is an indication of obesity. According to the statistic, 68% of American population are either overweight or obese.
You can calculate your BMI index BMI= weight (kg)/ height (m2)
The association of Obesity with Impotence
1. In a study of "Obesity and sexual dysfunction, male and female" by Esposito K, Giugliano F, Ciotola M, De Sio M, D'Armiento M, Giugliano D" ( from Source Division of Metabolic Diseases, Department of Geriatrics and Metabolic Diseases, University of Naples SUN, Naples, Italy. katherine.esposito@unina2.it, Int J Impot Res. 2008 Jul-Aug;20(4):358-65. Epub 2008 Apr 10), posted in PubMed, researchers stated that
a. Overweight and obesity may increase the risk of erectile dysfunction (ED) by 30-90% as compared with normal weight subjects. On the other hand, subjects with ED tend to be heavier and with a greater waist than subjects without ED, and also are more likely to be hypertensive and hypercholesterolemic.
b. The metabolic syndrome, characterized by a clustering of risk factors associated with insulin resistance and abdominal obesity, associates with ED.
2. According to the abstract of study of "Mechanisms of obesity and related pathologies: androgen deficiency and endothelial dysfunction may be the link between obesity and erectile dysfunction" by Traish AM, Feeley RJ, Guay A. (Source from Department of Biochemistry and Urology, Boston University School of Medicine, MA 02118, USA. atraish@bu.edu, FEBS J. 2009 Oct;276(20):5755-67. Epub 2009 Sep 15), posted in PubMed, researchers found that visceral obesity, a component of the metabolic syndrome, adversely affects endothelial function and testosterone levels, contributing to hypogandism and erectile dysfunction. Thus, clinical screening for the risk of erectile dysfunction in obese patients should include the assessment of waist circumference, testosterone levels, body mass index and physical inactivity.
3. According to the study of "Androgen deficiency and abnormal penile duplex parameters in obese men with erectile dysfunction" by Zohdy W, Kamal EE, Ibrahim Y. (Source from University of Cairo, Department of Andrology, Cairo, Egypt. wzohdy62@hotmail.com, J Sex Med. 2007 May;4(3):797-808), posted in PubMed, researchers indicated that Obesity is associated with lower TT and disturbances of penile hemodynamics. It is an independent clinical factor for vasculogenic ED.
4. In a study of "Obesity, low testosterone levels and erectile dysfunction" by Diaz-Arjonilla M, Schwarcz M, Swerdloff RS, Wang C. (Source from Division of Endocrinology, Department of Medicine, Harbor-UCLA Medical Center, Torrance, CA 90803, USA.Int J Impot Res. 2009 Mar-Apr;21(2):89-98. Epub 2008 Oct 9), researchers found that the relationships between low serum testosterone concentrations and ED in obese patients and those with metabolic syndrome and type 2 diabetes mellitus.
5. According to the abstract of study of "Complications of a buried penis in an extremely obese patient" by Mattsson B, Vollmer C, Schwab C, Padevit C, Horton K, John H, Horstmann M. (Source from Department of Urology, Kantonsspital Winterthur, Winterthur, Switzerland.© 2011 Blackwell Verlag GmbH), posted in PubMed, researchers concluded that Whereas acute complications of a buried penis in obese patients include local infection and urinary retention, chronic problems are undirected voiding, disturbed vaginal penetration and erectile dysfunction. Even though several surgical techniques are described, weight reduction should be primarily preferred.
6. In a study of "Body mass index regulates hypogonadism-associated CV risk: results from a cohort of subjects with erectile dysfunction" by Corona G, Rastrelli G, Monami M, Melani C, Balzi D, Sforza A, Forti G, Mannucci E, Maggi M. (Source from Sexual Medicine and Andrology Unit, University of Florence, Florence, Italy, © 2011 International Society for Sexual Medicine.), posted in PubMed, researchers found that Hypogonadism-associated CV risk depends on the characteristics of subjects, being more evident in normal weight than in obese patients. Further studies are advisable to clarify if low T in obese patients is a (positive) consequence of a comorbid condition (i.e., to save energy) or if it represents a pathogenetic issue of the same illness. Hence, possible misuse/abuse of T treatment in obese subjects must be avoided.
7. Etc.
Treatments of Obesity induced Impotence
1. According to the study of "The importance of risk factor reduction in erectile dysfunction" by
Jackson G. (Source from Cardiothoracic Centre, 6th floor, East Wing, St. Thomas' Hospital, Lambeth Palace Road, London, SE1 7EH, United Kingdom. gjcardiol@talk21.com, Curr Urol Rep. 2007 Nov;8(6):463-6.), posted in PubMed, researchers Intensive intervention with lifestyle advice focusing on a healthy diet, weight loss, and increased physical activity benefits men with ED, reducing the markers of inflammation and improving endothelial function. Though phosphodiesterase type 5 inhibitors are highly effective in treating ED, lifestyle advice and aggressive risk reduction remain fundamental to the overall vascular good health of the individual.
2. In a study of "Beneficial impact of exercise and obesity interventions on erectile function and its risk factors" by Hannan JL, Maio MT, Komolova M, Adams MA. (Source fromDepartment of Pharmacology and Toxicology, Queen's University, Kingston, Ontario, Canada,J Sex Med. 2009 Mar;6 Suppl 3:254-61), posted in PubMed, the result showed that Physical inactivity negatively impacts on erectile function, and experimental and clinical exercise interventions have been shown to improve sexual responses and overall cardiovascular health. Mediterranean-style diets and a reduction in caloric intake have been found to improve erectile function in men with the aspects of the metabolic syndrome. In addition, both clinical and experimental studies have confirmed that combining the two interventions provides additional benefit to erectile function, likely via reduced metabolic disturbances (e.g., inflammatory markers, insulin resistance), decreased visceral adipose tissue, and improvement in vascular function (e.g., increased endothelial function), researchers concluded that Lifestyle modifications provide significant benefits to vascular health and erectile function in a population that is increasingly aged and more obese.
3. In an abstract of the study of "Physical activity and erectile dysfunction in middle-aged men : a brief review" by La Vignera S, Condorelli R, Vicari E, D'Agata R, Calogero A. (J Androl. 2011 May 19. [Epub ahead of print]), posted in PubMed researchers found that Conflicting data regarding the effects of exercise on the androgen status. In clinical practice would be recommended to add regular physical activity to balanced diet and drugs to achieve better therapeutic results.
4. Etc.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Obesity is a medical condition of excess body fat accumulated overtime, while overweight is a condition of excess body weight relatively to the height. According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered over weight, while a BMI of over 30 is an indication of obesity. According to the statistic, 68% of American population are either overweight or obese.
You can calculate your BMI index BMI= weight (kg)/ height (m2)
The association of Obesity with Impotence
1. In a study of "Obesity and sexual dysfunction, male and female" by Esposito K, Giugliano F, Ciotola M, De Sio M, D'Armiento M, Giugliano D" ( from Source Division of Metabolic Diseases, Department of Geriatrics and Metabolic Diseases, University of Naples SUN, Naples, Italy. katherine.esposito@unina2.it, Int J Impot Res. 2008 Jul-Aug;20(4):358-65. Epub 2008 Apr 10), posted in PubMed, researchers stated that
a. Overweight and obesity may increase the risk of erectile dysfunction (ED) by 30-90% as compared with normal weight subjects. On the other hand, subjects with ED tend to be heavier and with a greater waist than subjects without ED, and also are more likely to be hypertensive and hypercholesterolemic.
b. The metabolic syndrome, characterized by a clustering of risk factors associated with insulin resistance and abdominal obesity, associates with ED.
2. According to the abstract of study of "Mechanisms of obesity and related pathologies: androgen deficiency and endothelial dysfunction may be the link between obesity and erectile dysfunction" by Traish AM, Feeley RJ, Guay A. (Source from Department of Biochemistry and Urology, Boston University School of Medicine, MA 02118, USA. atraish@bu.edu, FEBS J. 2009 Oct;276(20):5755-67. Epub 2009 Sep 15), posted in PubMed, researchers found that visceral obesity, a component of the metabolic syndrome, adversely affects endothelial function and testosterone levels, contributing to hypogandism and erectile dysfunction. Thus, clinical screening for the risk of erectile dysfunction in obese patients should include the assessment of waist circumference, testosterone levels, body mass index and physical inactivity.
3. According to the study of "Androgen deficiency and abnormal penile duplex parameters in obese men with erectile dysfunction" by Zohdy W, Kamal EE, Ibrahim Y. (Source from University of Cairo, Department of Andrology, Cairo, Egypt. wzohdy62@hotmail.com, J Sex Med. 2007 May;4(3):797-808), posted in PubMed, researchers indicated that Obesity is associated with lower TT and disturbances of penile hemodynamics. It is an independent clinical factor for vasculogenic ED.
4. In a study of "Obesity, low testosterone levels and erectile dysfunction" by Diaz-Arjonilla M, Schwarcz M, Swerdloff RS, Wang C. (Source from Division of Endocrinology, Department of Medicine, Harbor-UCLA Medical Center, Torrance, CA 90803, USA.Int J Impot Res. 2009 Mar-Apr;21(2):89-98. Epub 2008 Oct 9), researchers found that the relationships between low serum testosterone concentrations and ED in obese patients and those with metabolic syndrome and type 2 diabetes mellitus.
5. According to the abstract of study of "Complications of a buried penis in an extremely obese patient" by Mattsson B, Vollmer C, Schwab C, Padevit C, Horton K, John H, Horstmann M. (Source from Department of Urology, Kantonsspital Winterthur, Winterthur, Switzerland.© 2011 Blackwell Verlag GmbH), posted in PubMed, researchers concluded that Whereas acute complications of a buried penis in obese patients include local infection and urinary retention, chronic problems are undirected voiding, disturbed vaginal penetration and erectile dysfunction. Even though several surgical techniques are described, weight reduction should be primarily preferred.
6. In a study of "Body mass index regulates hypogonadism-associated CV risk: results from a cohort of subjects with erectile dysfunction" by Corona G, Rastrelli G, Monami M, Melani C, Balzi D, Sforza A, Forti G, Mannucci E, Maggi M. (Source from Sexual Medicine and Andrology Unit, University of Florence, Florence, Italy, © 2011 International Society for Sexual Medicine.), posted in PubMed, researchers found that Hypogonadism-associated CV risk depends on the characteristics of subjects, being more evident in normal weight than in obese patients. Further studies are advisable to clarify if low T in obese patients is a (positive) consequence of a comorbid condition (i.e., to save energy) or if it represents a pathogenetic issue of the same illness. Hence, possible misuse/abuse of T treatment in obese subjects must be avoided.
7. Etc.
Treatments of Obesity induced Impotence
1. According to the study of "The importance of risk factor reduction in erectile dysfunction" by
Jackson G. (Source from Cardiothoracic Centre, 6th floor, East Wing, St. Thomas' Hospital, Lambeth Palace Road, London, SE1 7EH, United Kingdom. gjcardiol@talk21.com, Curr Urol Rep. 2007 Nov;8(6):463-6.), posted in PubMed, researchers Intensive intervention with lifestyle advice focusing on a healthy diet, weight loss, and increased physical activity benefits men with ED, reducing the markers of inflammation and improving endothelial function. Though phosphodiesterase type 5 inhibitors are highly effective in treating ED, lifestyle advice and aggressive risk reduction remain fundamental to the overall vascular good health of the individual.
2. In a study of "Beneficial impact of exercise and obesity interventions on erectile function and its risk factors" by Hannan JL, Maio MT, Komolova M, Adams MA. (Source fromDepartment of Pharmacology and Toxicology, Queen's University, Kingston, Ontario, Canada,J Sex Med. 2009 Mar;6 Suppl 3:254-61), posted in PubMed, the result showed that Physical inactivity negatively impacts on erectile function, and experimental and clinical exercise interventions have been shown to improve sexual responses and overall cardiovascular health. Mediterranean-style diets and a reduction in caloric intake have been found to improve erectile function in men with the aspects of the metabolic syndrome. In addition, both clinical and experimental studies have confirmed that combining the two interventions provides additional benefit to erectile function, likely via reduced metabolic disturbances (e.g., inflammatory markers, insulin resistance), decreased visceral adipose tissue, and improvement in vascular function (e.g., increased endothelial function), researchers concluded that Lifestyle modifications provide significant benefits to vascular health and erectile function in a population that is increasingly aged and more obese.
3. In an abstract of the study of "Physical activity and erectile dysfunction in middle-aged men : a brief review" by La Vignera S, Condorelli R, Vicari E, D'Agata R, Calogero A. (J Androl. 2011 May 19. [Epub ahead of print]), posted in PubMed researchers found that Conflicting data regarding the effects of exercise on the androgen status. In clinical practice would be recommended to add regular physical activity to balanced diet and drugs to achieve better therapeutic results.
4. Etc.
Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
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The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
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