Medical Advisor Journals

Thursday, June 16, 2016

Phytochemicals in Foods - The Effects of Campesterol

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Campesterol

Campesterol is a phytochemincal in the class of Phytosterols, belonging to the group of Lipids, found abundantly in banana, pomegranate, pepper, coffee, grapefruit, cucumber, onion, oat, potato, etc.

Health benefits
1. Cardiovascular diseases
In the review of the studies published between January 1950 and April 2010 that reported either risk ratios (RR) of CVD in relation to serum sterol concentrations (either absolute or expressed as ratios relative to total cholesterol) or serum sterol concentrations in CVD cases and controls separately, indicated that 17 studies using different designs (four case-control, five nested case-control, three cohort, five cross-sectional) involving 11 182 participants. Eight studies reported RR of CVD and 15 studies reported serum concentrations in CVD cases and controls. Funnel plots showed evidence for publication bias indicating small unpublished studies with non-significant findings. Neither of our meta-analyses suggested any relationship between serum concentrations of sitosterol and campesterol (both absolute concentrations and ratios to cholesterol) and risk of CVD. Our systematic review and meta-analysis did not reveal any evidence of an association between serum concentrations of plant sterols and risk of CVD, according to "Plant sterols and cardiovascular disease: a systematic review and meta-analysis" by Genser B, Silbernagel G, De Backer G, Bruckert E, Carmena R, Chapman MJ, Deanfield J, Descamps OS, Rietzschel ER, Dias KC, März W.(1)

2. Cholesterol
In the investigation of Phytosterols (PSs),a group of plant derived steroid alcohols, with wide occurrence in vegetables and fruits, indicated that Structural resemblance of PSs with cholesterol enables them to displace low-density lipoprotein (LDL) cholesterol in the human intestine. Protective effects of PSs against cardiovascular diseases (CVDs), colon and breast cancer developments have been widely documented. Several reports have been published on the potential dietary intake of common PSs, such as β-sitosterol, stigmasterol andcampesterol, and their safety concerns. Ability of PSs to reduce cholesterol levels and risks associated with heart problems has made them a class of favorite food supplement, according to "Phytosterols: perspectives in human nutrition and clinical therapy' by Choudhary SP, Tran LS.(2)

3. Weight loss
In the assessment of the effects of 2 y of weight loss achieved with various diet regimens on phytosterols (markers of intestinal cholesterol absorption), lanosterol (marker of de novo cholesterol synthesis), and changes in apolipoprotein concentrations, found that a significant upregulation of the markers of cholesterol absorption (campesterol: +16.8%, P < 0.001) and a downregulation of the markers of cholesterol synthesis (lanosterol: -16.5%, P = 0.008) during the active weight-loss phase (first 6 mo, weight loss of 5%, 6%, and 10% in the 3 diet groups, respectively), followed by a rebound (campesterol: -6.2%, P = 0.045; lanosterol: +43.7%, P < 0.001) during the next 18 mo (weight gain of 1%, 1%, and 2% in the 3 diet groups, respectively). HDL cholesterol continuously increased during the study (17.0%, P < 0.001), whereas LDL cholesterol remained constant. At the end of the 24-mo follow-up period, campesterol (P < 0.001) and lanosterol (P = 0.016) amounts were significantly higher than baseline values, according to "Effects of a 2-y dietary weight-loss intervention on cholesterol metabolism in moderately obese men" by Leichtle AB, Helmschrodt C, Ceglarek U, Shai I, Henkin Y, Schwarzfuchs D, Golan R, Gepner Y, Stampfer MJ, Blüher M, Stumvoll M, Thiery J, Fiedler GM.(3)

4. Anti cancers
In the investigation of extract of Typhonium giganteum Engl. (BaiFuzi) by GC-MS, including the four major components [β-sitosterol (40.22%), campesterol (18.45%), n-hexadecanoic acid (9.52%) and (Z,Z)-9,12-octadecadienoic acid (8.15%)] found that the extract caused down-regulation of Bcl-2 expression, and up-regulation of Bax expression. Moreover, caspase-3 and caspase-9 protease activity significantly increased in a dose-dependent manner. Collectively, our results showed that the SFE-CO(2) extract from T. giganteum Engl. tubers induces apoptosis in SMMC-7721 cells involving a ROS-mediated mitochondrial signalling pathway, according to "SFE-CO2 extract from Typhonium giganteum Engl. tubers, induces apoptosis in human hepatoma SMMC-7721 cells involvement of a ROS-mediated mitochondrial pathway" by Li Q, Jiang C, Zu Y, Song Z, Zhang B, Meng X, Qiu W, Zhang L.(4)

5. Lung cancer
In the evaluation of the inhibitory effect of Typhonium blumei (Tb) extract on the viability of different cancer cells and the apoptotic effect of this extract on A549 lung cancer cells, indicated that dibutyl phthalate, α-linolenic acid, phytol,campesterol, stigmasterol and β-sitosterol were the major bioactive ingredients of Tb extract. Although all these compounds had good anti-proliferative effects on A549 cells, campesterol (IC(50)=2.2 μM for 24h treatment) and β-sitosterol (IC(50)=1.9 μM for 24h treatment) displayed the greatest inhibitory activity, according to "Typhonium blumei extract inhibits proliferation of human lung adenocarcinoma A549 cells via induction of cell cycle arrest and apoptosis" by
Hsu HF, Huang KH, Lu KJ, Chiou SJ, Yen JH, Chang CC, Houng JY.(5)

6. Cognitive effects
In the investigation of whether plant sterols in the brain are associated with alterations in brain cholesterol homeostasis and subsequently with brain functions, found that plant sterol accumulation resulted in decreased levels of desmosterol (P<0.01) and 24(S)-hydroxycholesterol (P<0.01) in the hippocampus, the brain region important for learning and memory functions, and increased lanosterol levels (P<0.01) in the cortex. However, Abcg5-/- and Abcg5+/+ displayed no differences in memory functions or in anxiety and mood related behavior. The swimming speed of the Abcg5-/- mice was slightly higher compared to Abcg5+/+ mice (P<0.001), according to "Cerebral accumulation of dietary derivable plant sterols does not interfere with memory and anxiety related behavior in Abcg5-/- mice" by Vanmierlo T, Rutten K, van Vark-van der Zee LC, Friedrichs S, Bloks VW, Blokland A, Ramaekers FC, Sijbrands E, Steinbusch H, Prickaerts J, Kuipers F, Lütjohann D, Mulder M.(6)

7. Antibacterial activity and mutagenicity
In the investigation of leaves of Alchornea triplinervia led to the isolation of the known substances quercetin, quercetin-7-O-beta-D-glucopyranoside, quercetin-3-O-beta-D-glucopyranoside, quercetin-3-O-beta-D-galactopyranoside, quercetin-3-O-alpha-L-arabinopyranoside, amentoflavone, brevifolin carboxylic acid, gallic acid, and methyl gallate from the methanolic extract, and stigmasterol, campesterol, sitosterol, lupeol, friedelan-3-ol, and friedelan-3-one from the chloroform extract, found that the methanolic extract showed antibacterial activity and mutagenicity, and is promising activity against Staphylococcus aureus (MIC = 62.5 microg/mL) and was slightly mutagenic in vitro and in vivo at the highest concentrations tested (1335 mg/kg b.w.), according to "Phenolic compounds in leaves of Alchornea triplinervia: anatomical localization, mutagenicity, and antibacterial activity" by Calvo TR, Demarco D, Santos FV, Moraes HP, Bauab TM, Varanda EA, Cólus IM, Vilegas W.(7)

8. Weight loss, hepatic steatosis, inflammation, and LDL-apoB-100 metabolism
In a 16-week intervention trial of a hypocaloric, low-fat diet plus 10 mg/day ezetimibe (n = 15) versus a hypocaloric, low-fat diet alone (n = 10) on intrahepatic triglyceride (IHTG) content, plasma high sensitivity-C-reactive protein (hs-CRP), adipocytokines, and fetuin-A concentrations and apolipoprotein (apo)B-100 kinetics in obese subjects, found that compared with weight loss alone, ezetimibe plus weight loss significantly (all P < 0.05) decreased IHTG content (-18%), plasma hs-CRP (-53%), interleukin-6 (-24%), LDL cholesterol (-18%), campesterol (-59%), and apoB-100 (-14%) levels, with a significant increase in plasma lathosterol concentrations (+43%). The LDL-apoB-100 concentration also significantly fell with ezetimibe plus weight loss (-12%), chiefly owing to an increase in the corresponding fractional catabolic rate (+29%) and suggested that Addition of ezetimibe to a moderate weight loss diet in obese subjects can significantly improve hepatic steatosis, inflammation, and LDL-apoB-100 metabolism, according to "Effect of ezetimibe on hepatic fat, inflammatory markers, and apolipoprotein B-100 kinetics in insulin-resistant obese subjects on a weight loss diet" by Chan DC, Watts GF, Gan SK, Ooi EM, Barrett PH.(8)

9. Etc.

Food therapy - Vegetables - GARLICS (Allium sativum)(1)

Garlic is the natural superfood healer for its natural antibiotic with antiviral, antifungal, anticoagulant and antiseptic properties. Garlic cooked is fine but it loses many of its health-giving powers. Raw garlic does most of its antibiotic and preventive medicines. Here are some of effective use of garlics for PROVEN DISEASE CURED.

*Garlic For BLOOD FORTIFIER. Raw garlic is said to do a super job of blood fortifying. It also helps REJUVENATE the body. Eat raw garlic and garlic supplements daily.

CAUTION: If you have a BLEEDING DISORDER, ULCER, OR TAKING ANTICOAGULANTS DO NOT TAKE GARLIC or GARLIC SUPPLEMENTS.

*Garlic For CHOLESTEROL: Eating 4 cloves of garlic a day can cut total CHOLESTEROL by 70%(Fresh or Supplement). The member of the allium family fights poor circulation.The sulfur compound in garlic keep your platelets from clumping together. It helps UNCLOG your Arteries but check with your Doctor if you are taking Blood thinning medications. Cook with both Garlic and onion to fight high blood pressure effectively. Try to take them everyday if you have high blood pressure and Cholesterol.

*Garlic to fight COLD and FLU. The natural compoud Allicin is released when garlic is crushed. Allicin works to fight cold, flu and other infections by breaking down into smaller chemicals called Sulfur compounds. They wake up your inmuune system, helping your body to get rid of toxins and microorganisms naturally.

*Garlic for VARICOSE VEINS. Garlic helps to keep your blood from clumping or becoming too sticky, helping your blood move through your blood vessels and reduces the risk of blood clots. One clove a day should do the trick. You can also take garlic capsules. CAUTION: Medication and Garlic could lead to uncontrolled bleeding and spell HEMORRHAGIC STROKES if it occurs in your brain. To avoid this, take caution against taking standardized garlic extract. Experts suggest eating no more than one clove of garlic a day.

Theres more than just GARLIC that can help to improve your quality of life, health,.... and Longevity. We ask you to read the complete analysis of this atSuper Foods Library.

You will have the chance to learn more of other Superfoods that we will discuss later on. Please use the information wisely. If you have any doubt of any of the side effects, please consult with your doctor before using it. ONCE AGAIN, CAUTION: If you have a BLEEDING DISORDER, ULCER, OR TAKING ANTICOAGULANTS DO NOT TAKE GARLIC or GARLIC SUPPLEMENTS.

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

Most Common Diseases of Men of 50Plus - Erectile Dysfunction Treatment of Low levels of Testosterone and Men's Libido

Traditional Chinese Medicine Herbal Therapy - Popular Chinese Herbs – Bei Mei Sheng Ma or Sheng Ma (Rhizoma Cimicifugae)

Ingredients
1. Cimitin
2. Cimigenol
3. Visnagin
4. Visamminol
5. Indole
6. Alkaloids
7. Cimicifugine
8. b-sitosterol
9. Cimigenol xyloside
10 Dahurinol
11. Isodahurinol
12.Dehydroxydahurinol
25-0-methylisodahurinol
26. Isoferulicacid
27. 25-0-methylisodahurinol
28. Isoferulicacid
29. Visnagin
30. Visamminol
31. Etc.

Health Benefits

1. Osteoporosis
Cimicifuga heracleifolia (CH), an Asian species of Cimicifugae rhizome has prevented the OVX-induced increase in body weight but did not alter the uterus weight of the OVX(ovariectomized) mice and significantly preserved trabecular bone mass, bone volume, trabecular number, trabecular thickness, structure model index and bone mineral density of proximal tibia metaphysis or distal femur metaphysis, according to the study of “Evaluation of the Antiosteoporotic Potential of Cimicifuga heracleifolia in Female Mice” by Ahn BS, Yang M, Jang H, Lee HJ, Moon C, Kim JC, Jung U, Jo SK, Jang JS, Kim SH.(1).

2. Anti-inflammatory activity
aqueous C. racemosa root extracts (CRE) and its phenolcarboxylic constituents have reduced LPS(lipopolysaccharide)-induced release of IL-6 and TNF-alpha in a concentration- and time-dependent manner and almost completely blocked release of IFN-gamma into the plasma supernatant. Except for IFN-gamma, these effects were attenuated at longer incubation periods. IL-8 secretion was stimulated by CRE, according to the study of “Aqueous extracts of Cimicifuga racemosa and phenolcarboxylic constituents inhibit production of proinflammatory cytokines in LPS-stimulated human whole blood” by Schmid D, Woehs F, Svoboda M, Thalhammer T, Chiba P, Moeslinger T.(2).

3. Infertility
Additional oral phytoestrogen (Cimicifuga racemosa) dry extract to clomiphene citrate induction can improve the pregnancy rate and cycle outcomes in couples with unexplained cause of infertility, according to the study of “Adding phytoestrogens to clomiphene induction in unexplained infertility patients–a randomized trial” by Shahin AY, Ismail AM, Zahran KM, Makhlouf AM.(3).

4. Anti-microbial and in vivo cytokine modulating effects
Ching-Wei-San, the formula in traditional Chinese medicine, including Cimicifuga foetida has exerted the inhibitory effects on three well-known plaque-causing bacteria, Porphyromonas gingivialis, Streptococcus sanguis, and Streptococcus mutans, and two common pathogens, Staphylococcus aureus and Escherichia coli, according to the study of “In vitro anti-microbial and in vivo cytokine modulating effects of different prepared Chinese herbal medicines” by Lin SJ, Chen CS, Lin SS, Chou MY, Shih HC, Lee IP, Kao CT, Ho CC, Chen FL, Ho YC, Hsieh KH, Huang CR, Yang CC.(4).

5. Anti-herpes simplex virus
Berberine is an alkaloid extracted from Coptidis rhizome. Among the individual herbal components of a Chinese herb medicine, Ching-Wei-San, including Cimicifuga foetida has interfered with the viral replication cycle after virus penetration and no later than the viral DNA synthesis step, and its activities were not affected by the preparation processes. according to the study of “Anti-herpes simplex virus effects of berberine from Coptidis rhizoma, a major component of a Chinese herbal medicine, Ching-Wei-San” by Chin LW, Cheng YW, Lin SS, Lai YY, Lin LY, Chou MY, Chou MC, Yang CC.(5).

6. Anticomplement activity
Cimilactone A in A tetranor-cycloartane glycoside and two 9,19-cycloartane glycosides isolated from the EtOAc-soluble fraction of the rhizome of Cimicifuga foetida has shown significant anticomplement activity against the classical pathway of the complement system, according to the study of “Anticomplement activity of cycloartane glycosides from the rhizome of Cimicifuga foetida” by Qiu M, Kim JH, Lee HK, Min BS.(6).

7. Etc.

Side effect
1. Black cohosh should be used with caution during pregnancy, particularly during the first trimester, because of its purported labour-inducing effects, according to the study of “Safety and efficacy of black cohosh (Cimicifuga racemosa) during pregnancy and lactation” by Dugoua JJ, Seely D, Perri D, Koren G, Mills E.(a)
2. Do not use the herb when measles is fully ripened.
3. Overdoses can cause headaches, dizziness, vomiting, tremor, gastrointestinal disorder, etc.
4. The herb may cause liver disease, according to the study of “Suspected black cohosh hepatotoxicity–challenges and pitfalls of causality assessment” by Teschke R, Bahre R, Genthner A, Fuchs J, Schmidt-Taenzer W, Wolff A.(b)
5. Etc.

Most Common Diseases of 50Plus:The Research and Studies of Ischemic heart disease - Treatments In Traditional Chinese medicine perspective

Cardiovascular Disease

Cardiovascular disease is defined as medical conditions affecting the cardiovascular system, including heart, blood vessels(arteries and veins).
Beside cancer, heart disease kills more than 2,000 Americans everyday. Approximately 60 million Americans have heart disease.
There are many causes of heart diseases. Most of heart diseases are caused by high blood pressure contributes to hardening of the arteries. High levels of bad cholesterol (LDL) build up in the arteries as a result of uncontrolled diet with high levels of saturated fat and trans fat. All these add to the formation of atherosclerosis lesions and eventually arterial blockage or anything that serves to damage the inner lining of blood vessels and impedes the transportation of oxygen and nutrition to the heart can be defined as a risk of heart disease.

Ischemic heart disease
Ischemic heart disease is defined as a condition of reduced blood supply of the heart muscle, as a result of coronary artery disease caused by plague building up in the arteries.

The Treatments

In Tranditional Chinese medicine perspective
According to the A Practical English-Chinese Library of Traditional Chinese Medicine by Dr. Enqin Zhang(Engin CAN),[graduated from Shandong University of Traditional Chinese Medicine (TCM) in 1982 with post-graduate dip., Master of Medicine and later also got his MD and Professorship in Alternative Medicine /TCM from 4 international and Chinese universities and institutes. He was the chief editor& author of book “Research in Classical Formulae of TCM”, published by Yellow River Press in 1987 as well as TCM series ‘A Practical English-Chinese Library of TCM](117)

Precordial pain as a result of obstruction in the heart vessels is the most prominent feature of coronary heart disease due to obstructs the yang qi, and /or by blood stasis,caused by either qi deficiency or due to qi stagnation of that lead to phlegm accumulation in the chest .
Dr. Enqin Zhang differentiated coronary heart disease as follow(118)
1.. Obstruction of yang qi in the chest due to accumulation of phlegm
a. Primary manifestations: A feeling of oppression over the chest or chest pain radiating to the back, accompanied by shortness of breath, white, thick, greasy coating of the tongue and smooth pulse. (This condition is of the cold phlegm type; when the tongue coating turns yellow and greasy, it becomes a phlegm-heat type.)
b. Principle of treatment: Relieve the obstruction of the yang qi in the chest.

c. Formula treatment
Formula for choice: Trichosanthes, Chinese Chive, and White Liquor Decoction; in this prescription, trichosanthes fruit eliminates phlegm and reverse the adverse ascending of the qi; Chinese chive warms and activates the yang qi in the chest and relieves pain; and white liquor acts as a guide drug.

2. Blood stasis caused by qi deficiency
a. Primary manifestations: Fatigue, shortness of breath, palpitations accompanied by localized pain, dark purplish tongue with thin coating and uneven pulse. (In cases with cold extremities, intolerance of cold, pale and tender tongue and slow pulse, the blood stasis is due to yang deficiency; in cases with profuse sweating, deadly cold limbs, listlessness and fading pulse or even coma, the yang is exhausted and shock ensues. Some patients experience yin and qi deficiencies together, manifested by a hot sensation in the palms and soles, dry mouth, desire for cold drinks, reddened tongue with little or no coating and thin, rapid pulse.)
b. Principle of treatment: Invigorate the qi and promote blood circulation.
c. Formula treatment
Principle of treatment: Invigorate the qi and promote blood circulation.
Formula of choice: Yang-Invigorating and Recuperation Decoction; in this recipe, astragalus root (huang qi) invigorates the qi to promote blood circulation and strengthens the effect of the other ingredients in removing blood stasis. Other ingredients are tangkuei (dang gui), red peony root (chi shao), earth worm (di long), ligusticum root (chuan xiong), peach kernel (tao ren), carthamus flower (hong hua).
In cases with yang deficiency, add cuscuta seed (tu si zi), prepared lateral root of aconite (fu zi), and psoralea seed (bu gu zhi) to warm and replenish the yang qi.
If there is collapse, use Ginseng and Aconite Decoction combining with Aconite Decoction (including prepared lateral root of aconite, poria, ginseng, ovate atractylodes rhizome, white peony root); in these prescriptions, prepared lateral root of aconite and ginseng recuperate the depleted yang and replenish the qi. In cases of qi and yin deficiencies, add scrophularia root (xuan shen), ophiopogon root (mai dong), schisandra berry (wu wei zi), and fresh rehmannia root (sheng di ) to the above prescriptions.

3. Blood stasis caused by qi stagnation
a. Primary manifestations: A fullness sensation or pain in the chest, dark purplish tongue with thin coating, but no symptoms of qi deficiency, such as shortness of breath and fatigue.
b. Principle of treatment: Activate qi and remove blood stasis.

c. Formula of choice: Blood House Stasis-Expelling Decoction; in this recipe, bitter orange (zhi ke) and bupleurum root (chai hu) activate the stagnated qi; platycodon root (jie geng) acts as a guide drug; and the other ingredients promote blood circulation and remove blood stasis, including tangkuei (dang gui), fresh rehmannia root (sheng di huang), peach kernel (tao ren), carthamus flower (hong hua), red peony root (chi shao), licorice root (gan cao), ligusticum root (chuan xiong), achyranthes root (niu xi).

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

References
(117) http://www.tcmtreatment.com/images/diseases/introduction.htm
(118) http://www.tcmtreatment.com/images/diseases/heartdisease.htm

Most Common Disease of 50plus: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Polymyalgia Arthritis (Rheumatica): The Individual herbs - Gingko

Musculoskeletal disorders (MSDs) are medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed(1).

Types of Musculo-Skeletal disorders in elder(2)
1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalgia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia

Polymyalgia Arthritis (Rheumatica)

Polymalgia Arthritis is defined as a condition a common inflammatory rheumatic disease which causes pain, stiffness and tenderness in large muscles, including muscles shoulders and pelvic girdle as a result of the presence of a synovitis in proximal joints and periarticular structures.

Treatments

B.2. Herbal and Traditional Chinese medicine
Herbal medicine from different cultures have been found effectively in reduced symptoms and treatment for patient with Polymyalagia Arthritis (Rheumatica), including
10. Gingko
Gingko is also known as Ginkgo biloba, one of the oldest herbal medicine in human medical history, used in traditional herbal medicine in treating impotence, memory loss,respiratory diseases, circulatory disorders,,...(477,230).
Gingko extract, with anti inflammatory(478,231) and immune modulatory(479,232) activities may be a potential herbal medicine for treatment of osteoarthritis by inhibiting the interleukin-1 (IL-1)-stimulated human chondrocytes degeneration and MMP(matrix metalloproteinases)-1, MMP-3, and 13.causes of cartilage degradation(481,233)(482,234) according to the Postgraduate Institute of Medical Education and Research(480, 235).

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

References
(477,230) Popular Herbs - Ginkgo biloba by Kyle J. Norton
(478,231) Ginkgo biloba extract EGb 761 has anti-inflammatory properties and ameliorates colitis in mice by driving effector T cell apoptosis by Venkata S. Kotakadi,† Yu Jin,† Anne B. Hofseth, Lei Ying, Xiangli Cui, Suresh Volate, Alexander Chumanevich, Patricia A. Wood,1 Robert L. Price,2 Anna McNeal,2 Udai P. Singh,2 Narendra P. Singh,2 Mitzi Nagarkatti,2 Prakash S. Nagarkatti,2 Lydia E. Matesic,3 Karine Auclair,4 Michael J. Wargovich,5 and Lorne J. Hofseth(PMC)
(479,232) Effectiveness of oral Ginkgo biloba in treating limited, slowly spreading vitiligo by Parsad D1, Pandhi R, Juneja A.(PubMed)
(481,233) Inhibitory effects of EGb761 on the expression of matrix metalloproteinases (MMPs) and cartilage matrix destruction by Wang X1, Zhao X, Tang S.(PubMed)
(482,234) EGb761 inhibits inflammatory responses in human chondrocytes and shows chondroprotection in osteoarthritic rat knee by Chen YJ1, Tsai KS, Chiu CY, Yang TH, Lin TH, Fu WM, Chen CF, Yang RS, Liu SH.(PubMed)
(480,235) Ginkgo biloba extract individually inhibits JNK activation and induces c-Jun degradation in human chondrocytes: potential therapeutics for osteoarthritis by Ho LJ1, Hung LF2, Liu FC3, Hou TY3, Lin LC4, Huang CY2, Lai JH5.(PubMed)