Medical Advisor Journals

Thursday, June 16, 2016

Herbal therapy: Popular Herbal Grapefruit Seed Extract

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Grapefruit Seed Extract

Grapefruit seed extract (GSE) is a liquid extracted from the seeds, pulp, and white membranes of grapefruit. The herb has been used in traditional medicine as an anti bacterial, viral, fungal, parasites and to enhance immune system, protect against colds and flu and malignant disease.

Health Benefits
1. Antibacterial activity
In the investigation of GSE for its antibacterial activity at varying time intervals and concentration levels and tissue toxicity found that with the aid of scanning transmission electron microscopy (STEM), the mechanism of GSE's antibacterial activity was revealed. It was evident that GSE disrupts the bacterial membrane and liberates the cytoplasmic contents within 15 minutes after contact even at more dilute concentrations, according to "The effectiveness of processedgrapefruit-seed extract as an antibacterial agent: II. Mechanism of action and in vitro toxicity" by Heggers JP, Cottingham J, Gusman J, Reagor L, McCoy L, Carino E, Cox R, Zhao JG(1)

2. Antimicrobial activity
In the determination of antibacterial and antifungal activity of ethanolic extract ofgrapefruit (Citrus paradisi Macf., Rutaceae) seed and pulp found that ethanolicextract exibited the strongest antimicrobial effect against Salmonella enteritidis (MIC 2.06%, m/V). Other tested bacteria and yeasts were sensitive to extractconcentrations ranging from 4.13% to 16.50% (m/V), according to "Antimicrobial activity of grapefruit seed and pulp ethanolic extract" by Cvetnić Z, Vladimir-Knezević S.(2)

3. Hypoglycemic and hypolipidemic effects
In observation of the glucose and lipid lowering effects of methanol seed extract ofCitrus paradisi Macfad (MECP) in alloxan-induced diabetic rats found that Oral treatment with 100 - 600 mg/kg/day MECP, for 30 days, resulted in significant (p < 0.05, p < 0.01, p < 0.001) reductions in FPG, TG, TC, LDL-c, VLDL-c in the diabetic rats, effects which were comparable to that of metformin. The extract also caused significant (p < 0.05, p < 0.01) rise in HDL-c values in the alloxan diabetic rats. Phytochemical result showed the presence of alkaloids, flavonoids, cardiac glycosides, tannins and saponin in varying concentrations. Results of this study lend support to the traditional use of grapefruit seeds in the management of type 1 diabetic patients and may suggest a role in orthodox management of the disease, according to "Hypoglycemic and hypolipidemic effects of methanol seedextract of Citrus paradisi Macfad (Rutaceae) in alloxan-induced diabetic Wistar rats" by Adeneye AA.(3)

4. Blood glucose, lipids and cardiovascular disease
In the assessment of blood glucose and lipid lowering effects as well as cardiovascular disease risk factor-reducing effect of Citrus paradisi Macfad (100% methanol seed extract) found that
Results showed significant (p < 0.05, p < 0.001) dose related lowering effects of the extract on FPG, cardiovascular disease risk assessing indices and lipid parameters except HDL-c fraction which was significantly (p < 0.05, p < 0.001) elevated. The extract also induced significant (p < 0.05) dose related weight loss in the treated rats in the latter 15 days of their treatment, according to "Methanolseed extract of Citrus paradisi Macfad lowers blood glucose, lipids and cardiovascular disease risk indices in normal Wistar rats" by Adeneye AA(4)

5. Gastroprotective effects
In the classification of plant-originated flavonoid substances from Solon (Sophoradin extract), Amaranth seed extract, grapefruit-seed extract (GSE) and capsaicin (extract of chilly pepper) amd theirs overprotective effects found that plant-originated flavonoid substances are highly gastroprotective probably due to enhancement of the expression of constitutive NOS and release of NO and neuropeptides such as calcitonin gene related peptide (CGRP) released from sensory afferent nerves increasing gastric microcirculation, according to "Gastroprotective effects of flavonoids in plant extracts" by Zayachkivska OS, Konturek SJ, Drozdowicz D, Konturek PC, Brzozowski T, Ghegotsky MR.(5)

6. Acute pancreatitis
In the determination of determine whether this GSE is also capable of preventing acute pancreatic damage induced by ischemia/reperfusion (I/R) found that GSE administered alone increased significantly pancreatic tissue content of lipid peroxidation products, malondialdehyde and 4-hydroxyalkens, and when administered before I/R, GSE reduced the pancreatitis-induced lipid peroxidation. We conclude that GSE exerts protective activity against I/R-induced pancreatitis probably due to the activation of antioxidative mechanisms in the pancreas and the improvement of pancreatic blood flow, according to "Extract of grapefruit-seed reduces acute pancreatitis induced by ischemia/reperfusion in rats: possible implication of tissue antioxidants" by Dembinski A, Warzecha Z, Konturek SJ, Ceranowicz P, Dembinski M, Pawlik WW, Kusnierz-Cabala B, Naskalski JW.(6)

7. Antioxidant activity
In analyzing the antioxidant activity of Citrus paradisi (grapefruit) seeds glycericextract dissolved in ethanol and in aqueous media found that grapefruit seedsglyceric extract utilized as aqueous solutions demonstrated antioxidant properties better than those displayed by alcoholic solutions. according to "Antioxidant activity of Citrus paradisi seeds glyceric extract" by Giamperi L, Fraternale D, Bucchini A, Ricci D.(7)

8. Anti cancers
In the demonstration of isolation of five limonoids from red Mexican grapefruitseeds and theirs inhibition of the growth of cancer in colon, lung, mouth, stomach and breast in animal and cell culture found that radical scavenging activity of 1,1-diphenyl-2-picrylhydrazyl (DPPH) and total phenolic content were also measured for comparison with the antioxidant capacity in the phosphomolybdenum method for the above extracts. Acetone and MeOH extracts, respectively, showed the highest (85.7%) and lowest (53.3%) radical scavenging activity, at 500 ppm. The total phenolic contents were found to be highest in the acetone extract (15.94%) followed by the MeOH extract (5.92%), ethyl acetate extract (5.54%) and waterextract (5.26%). Antioxidant capacity of the extracts as equivalents to ascorbic acid (micromol/g of the extract) was in the order, EtOAc extract > acetone extract> water extract > methanol extract, according to "Red Mexican grapefruit: a novel source for bioactive limonoids and their antioxidant activity" by Mandadi KK, Jayaprakasha GK, Bhat NG, Patil BS.(8)

9. Etc.

Side effects
1. The herb may interact with other medicine due to its inhibition of certain liver and small intestine enzymes
2. Overdoses may effect the liver function of which can lead to weaken muscle
3. Etc.

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/12165191
(2) http://www.ncbi.nlm.nih.gov/pubmed/15610620
(3) http://www.ncbi.nlm.nih.gov/pubmed/19391322
(4) http://www.ncbi.nlm.nih.gov/pubmed/19062465
(5) http://www.ncbi.nlm.nih.gov/pubmed/15800396
(6) http://www.ncbi.nlm.nih.gov/pubmed/15613745
(7) http://www.ncbi.nlm.nih.gov/pubmed/15030930
(8) http://www.ncbi.nlm.nih.gov/pubmed?term=Grapefruit%20seed%20extract%20and%20cancer

Most Common Diseases of 50Plus:The Research and Studies of Coronary heart disease - Treatment In Herbal medicine perspective

Cardiovascular disease is defined as medical conditions affecting the cardiovascular system, including heart, blood vessels(arteries and veins).

Beside cancer, heart disease kills more than 2,000 Americans everyday. Approximately 60 million Americans have heart disease.
There are many causes of heart diseases. Most of heart diseases are caused by high blood pressure contributes to hardening of the arteries. High levels of bad cholesterol (LDL) build up in the arteries as a result of uncontrolled diet with high levels of saturated fat and trans fat. All these add to the formation of atherosclerosis lesions and eventually arterial blockage or anything that serves to damage the inner lining of blood vessels and impedes the transportation of oxygen and nutrition to the heart can be defined as a risk of heart disease.

Coronary heart disease
Coronary heart disease is defined as a condition of narrowing coronary arteries that lead to blockage of the blood flow in the arteries as a result of hardening arterial wall, cholesterol building up in the arteries, chemicals, such as cadmium clog up arteries, etc. affecting the small blood vessels that supply blood and oxygen to the heart. Coronary heart disease (CHD) is the leading cause of death in the United States.

The Treatment

In Herbal medicine perspective
The aim of herbal medicines is to treat the underlining causes of Coronary heart disease. If the disease is caused by structure problem then convention medical surgery could be necessary

1. Ginger
a. Anti Diabetes and hypoglycaemic effect
In the evaluation of the hypoglycaemic potentials of ginger (Zingiber officinale) with extract of raw ginger was administered daily (500 mg/kg, intraperitoneally) for a period of 7 weeks to streptozotocin (STZ)-induced diabetic rats found that The STZ-injected rats exhibited hyperglycaemia accompanied with weight loss, indicating their diabetic condition. At a dose of 500 mg/kg, raw ginger was significantly effective in lowering serum glucose, cholesterol and triacylglycerol levels in the ginger-treated diabetic rats compared with the control diabetic rats, according to “Anti-diabetic and hypolipidaemic properties of ginger (Zingiber officinale) in streptozotocin-induced diabetic rats” by Zainab M. Al-Amina, Martha Thomsona, Khaled K. Al-Qattana, Riitta Peltonen-Shalabya/and Muslim Alia(97).

b. Ginger helps to lower cholesterol levels, elevated blood pressure and prevent blood clots in the arterial walls when taken with vitamin E. It also helps to stimulate and revitalize the heart muscle and strengthen the peripheral’s circulation(98).

2. Garlic
a. Cholesterol
Eating 4 cloves of garlic a day can cut total CHOLESTEROL by 70%(Fresh or Supplement). The member of the allium family fights poor circulation.The sulfur compound in garlic keep your platelets from clumping together. It helps UNCLOG your Arteries but check with your Doctor if you are taking Blood thinning medications. Cook with both Garlic and onion to fight high blood pressure effectively. Try to take them everyday if you have high blood pressure and Cholesterol.

b. Varicose veins
Garlic helps to keep your blood from clumping or becoming too sticky, helping your blood move through your blood vessels and reduces the risk of blood clots. One clove a day should do the trick. You can also take garlic capsules. CAUTION: Medication and Garlic could lead to uncontrolled bleeding and spell HEMORRHAGIC STROKES if it occurs in your brain. To avoid this, take caution against taking standardized garlic extract. Experts suggest eating no more than one clove of garlic a day(99).

3. Ashwagandha
In a study of hypercholesterolemic rats with the composite of Ashwagandha, conducted by Sardar Patel University has effectively effectively reduce plasma and hepatic lipid profiles and increased fecal excretion of cholesterol, neutral sterol, and bile acid along with increasing the hepatic HMG-CoA reductase activity and bile acid content in hypercholesterolemic rats(100).

4. Artichoke
a. Hypercholesterolaemia
People who have high levels of blood cholesterol are proven to be in increased risk for coronary heart disease and other sequelae of atherosclerosisstroke. Artichokeleaf extract (ALE) has demonstrated the effects of lowing the blood cholesterol in some researches, according to the abstract of study of “Artichoke leaf extract for treating hypercholesterolaemia” by Wider B, Pittler MH, Thompson-Coon J, Ernst E., posted in PubMed(101).

b. Antioxidant capacity
Artichoke contains high levels of antioxidant Flavonoids which can enhance the immune system fightinf against the forming of free radicals and guarding our body against foreign invasion such as bacteria and virus, thus reducing the risk of free radicals and bacteria and virus causes of infection and inflammation, according to the article of “Artichoke” posted in Wikipedia(102) c. Blood vessel integrity protection
Artichoke has shown a property of protection of the the layer of epithelial cells that lines the interior surface of blood vessels, according to the study of “The effect of artichoke (Cynara scolymus L.) extract on ROS generation in HUVEC cells” by Juzyszyn Z, Czerny B, Pawlik A, Droździk M.(103), researchers filed the conslusion in abstract that artichoke extract were demonstrated by the reduction kinetics of cytochrome c in reference to ascorbate were also revealed. The results of the present study the warrant application of artichoke extracts as endothelium protecting agents.

5. Parsley on Platelet aggregation and prolongs bleeding
In the determination of parsley (Petroselinum crispum, Apiaceae) used in In Morocco, used to treat cardiovascular diseases such as arterial hypertension, found that The oral administration of CAE (3g/kg) inhibited significantly (p<0.001) platelet aggregation ex vivo and prolonged bleeding time (p<0.001) without changes in the platelet amount. The prolongation of bleeding time by CAE may be attributed to the observed inhibition of platelet aggregation. These effects could be related in part to the polyphenolic compounds present in the extract. These results support the hypothesis that the dietary intake of parsley may be benefit in the normalization of platelet hyperactivation, in the nutritional prevention of cardiovascular diseases and are potentially interesting in the development of new prevention strategies, according to “Parsley extract inhibits in vitro and ex vivo platelet aggregation and prolongs bleeding time in rats” by Gadi D, Bnouham M, Aziz M, Ziyyat A, Legssyer A, Legrand C, Lafeve FF, Mekhfi H.(104) b. Spasmolytic effect
In the investigation of Traditional herbal medicines such as Petroselinum crispum(Parsley) used for treatment of intestinal disorders in Iran, found that adding extract before influence of KCl, cause reduced effect of KCl (n = 7, p < 0.001). In addition, the Tyrode solution without CaCl2 and high concentration of K+, various concentration of extract significantly (n = 7, p < 0.001) decreased the CaCl2-induced contraction. Therefore, it seems that the relaxation effect of extract alcoholic parsley seed on the contraction of ileum is performed by blocking of voltage-gated calcium channels, according to “Spasmolytic effect ofPetroselinum crispum (Parsley) on rat’s ileum at different calcium chloride concentrations” by Moazedi AA, Mirzaie DN, Seyyednejad SM, Zadkarami MR, Amirzargar A.(105).

6. Alfalfa
a. Antioxidant
In a study of measurements of pH, water holding capacity, color, oxymyoglobin content, TBARS and oxidation-reduction potential in evaluating the effects of a dietary protein-xanthophylls (PX) concentrate of alfalfa to turkey diets conducted by University of Life Sciences in Lublin, Skromna 8, 20-704 Lublin, Poland.(106), researchers found that TBARS and oxidation-reduction potential values suggested that the inclusion of the concentrate to turkey diets acts as an antioxidant in the raw meat.

b. Cholesterol
In a study to test the effect of Alfalfa used in traditional medicine to treat high blood cholesterol conducted by Malinow MR, McLaughlin P, Stafford C.(107), in 3 human volunteers during ingestion of diets containing alfalfa seeds (AS) for 3 weeks, researchers found that Plasma cholesterol concentrations were reduced and No signs of toxicity were detected through serum determinations of multiple parameters. The ingestion of AS in rats decreased the concentration of plasma cholesterol, reduced intestinal absorption of exogenous and endogenous cholesterol, and increased fecal biliary excretion.

c. Hyperlipoproteinemia
In a study of Fifteen patients with hyperlipoproteinemia (HLP), types IIA (n = 8), IIB (n = 3) and IV (n = 4) were given 40 g of heat prepared alfalfa seeds 3 times daily at mealtimes for 8 weeks with otherwise unchanged diet, conducted by Mölgaard J, von Schenck H, Olsson AG.(108), found that patients with type II HLPalfalfa treatment caused after 8 weeks a maximal lowering of pretreatment median values of total plasma cholesterol from 9.58 to 8.00 mmol/l (P less than 0.001) and low density lipoprotein (LDL) cholesterol from 7.69 to 6.33 mmol/l (P less than 0.01), which corresponds to decreases of 17% and 18%, respectively. Maximal decrease was 26% in total cholesterol and 30% in LDL cholesterol. In two patients with hypercholesterolemia the LDL cholesterol decreased less than 5%. Apolipoprotein B decreased in the same period from 2.17 to 1.43 g/l (P less than 0.05) in type II HLP, corresponding to 34% decrease, whereas apolipoprotein A-I did not change. Body weight increased slightly during the first 4 weeks of alfalfatreatment (P less than 0.001) probably because of the caloric content in the alfalfaseeds. After cessation of treatment, all lipoprotein concentrations returned to pretreatment levels. We conclude that alfalfa seeds can be added to the diet to help normalize serum cholesterol concentrations in patients with type II HLP.

7. Hawthorn
a. Hypotensive effects
In the investigation of Hawthorn (Crataegus laevigata) leaves, flowers and berries used by herbal practitioners in the UK to treat hypertension in conjunction with prescribed drugs indicated that this is the first randomised controlled trial to demonstrate a hypotensive effect of hawthorn in patients with diabetes takin, according to “Hypotensive effects of hawthorn for patients with diabetes taking prescription drugs: a randomised controlled trial” by Walker AF, Marakis G, Simpson E, Hope JL, Robinson PA, Hassanein M, Simpson HC(109).

b. Cardiac effects
In the evaluation of the potential cardiac effects of two alcohol extracts of commercially available hawthorn found that the mechanism of cardiac activity ofhawthorn is via the Na(+),K(+)-ATPase and intracellular calcium concentrations are influenced, according to “A comparison of the effects of commercially availablehawthorn preparations on calcium transients of isolated cardiomyocytes” by Rodriguez ME, Poindexter BJ, Bick RJ, Dasgupta A.(110).

c. Cardiovascular disease
In the analyzing the effect of hawthorn in prevention and protection of cardiovascular disease indicated that these beneficial effects may in part be due to the presence of antioxidant flavonoid components. While a number of studies have been performed to evaluate the clinical efficacy of hawthorn, an international, multicenter, prospective clinical study including a large number of New York Heart Association (NYHA) class II/III heart failure patients is ongoing to test hawthorn‘s long-term therapeutic effects, according to “Hawthorn: potential roles in cardiovascular disease“by Chang WT, Dao J, Shao ZH.(111).

d. Chronic heart failure
In the assessment of Hawthorn extract usedas an oral treatment option for chronic heart failure, found that Ten trials including 855 patients with chronic heart failure (New York Heart Association classes I to III) provided data that were suitable for meta-analysis. For the physiologic outcome of maximal workload, treatment withhawthorn extract was more beneficial than placebo (WMD (Watt) 5.35, 95% CI 0.71 to 10.00, P < 0.02, n = 380). Exercise tolerance were significantly increased by hawthorn extract (WMD (Watt x min) 122.76, 95% CI 32.74 to 212.78, n = 98). The pressure-heart rate product, an index of cardiac oxygen consumption, also showed a beneficial decrease with hawthorn treatment (WMD (mmHg/min) -19.22, 95% CI -30.46 to -7.98, n = 264). Symptoms such as shortness of breath and fatigue improved significantly with hawthorn treatment as compared with placebo (WMD -5.47, 95% CI -8.68 to -2.26, n = 239), according to “Hawthorn extract for treating chronic heart failure” by Pittler MH, Guo R, Ernst E.(112).

e. Hyperlipemia
in the determination of The Yishoujiangzhi (de-blood-lipid) tablets (composed of Radix Polygori Multiflori, Rhizoma Polygonati, Fructus Lycii, Crataegus Pinnatifida and Cassia Tora) and its effect on Hyperlipemia found that in the treatment of 130 cases of hyperlipemia, achieving an effective rate of 87.0% in lowering serum cholesterol and 80.8% in lowering triglyceride, according to ‘Yishou jiangzhi (de-blood-lipid) tablets in the treatment of hyperlipemia” by Guan Y, Zhao S.(113).

8. Gingko biloba
a. Hypertension
Ginkgo enhanced endothelium-dependent vasodilation and elevation of the endothelial intracellular Ca(2+) level in SHR, resulting in hypotension, according to the study of “Effects of Ginkgo biloba extract on blood pressure and vascular endothelial response by acetylcholine in spontaneously hypertensive rats” by Kubota Y, Tanaka N, Kagota S, Nakamura K, Kunitomo M, Umegaki K, Shinozuka K.(114).

b. Cardiovascular tissues
Ginkgo biloba extract (EGb) has shown the protection of the cardiovascular tissues against HgCl(2)-induced oxidative damage, according to the study of “Protective effects of Ginkgo biloba extract against mercury(II)-induced cardiovascular oxidative damage in rats” by Tunali-Akbay T, Sener G, Salvarli H, Sehirli O, Yarat A.(115).

The Obesity's Weight Loss Recipes: No toss lettuce

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Recipe attributed to Company's Coming Salads by Jean Parè

Choose iceberg lettuce or Chinese cabbage
Tarragon dressing
Sour cream 1/2 cup (125ml)
Tarragon vinegar 1tbsp. (15ml)
granulated sugar 2 tsp. (10ml)
Onion salt 1/2 tsp. (2ml)
Paprika 1/2 tsp. (2ml)
Salad
Lettuce chunks or wedges 6
Sliced green onion or thinly sliced onion ring 1/2 cup (125 ml)

Tarragon Dressing: Combined all 5 ingredients in a small bowl. Mix well
Salad: Arrange lettuce chunk on small size salad plate. Scatter onions over top. Spoon dressing over top, and serve. Serve 6

Variation: spoon French or thousand Island dressing over lettuce wedges.
Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

Traditional Chinese Medicine Herbal Therapy - Popular Chinese Herbs – Bian Dou (Semen Dolichoris Lablab)

Ingredients
1. Protein
2. Sucrose
3.Glucose
4. Maltodextrin
5. Stachyose
6. Raffinose
7. L-pipecolic acid
8. Phytoagglutinin
9. Phytin
10. Calcium
11. Phosphorus
12. Iron
13. Pantothenic acid
14. Etc.

Health Benefits
1. Antifungal and HIV Effects
In the investigation of an antifungal protein purified from the seeds of the field bean Dolichos lablab found that it exhibited antifungal activity against the fungi Fusarium oxysporum, Rhizoctonia solani and was capable of inhibiting human immunodeficiency virus (HIV) reverse transcriptase and alpha- and beta-glucosidases which are glycohydrolases implicated in HIV infection. according to the study of “Dolichin, a new chitinase-like antifungal protein isolated from field beans (Dolichos lablab)” by Ye XY, Wang HX, Ng TB.(1).

2. Stem cells preservation
In the study of the preservation of plant lectin extracted from Dolichos Lablab and sterm cells found that FRIL(Flt3 receptor-interacting lectin) could also preserve neural progenitor cells in vitro by inhibiting both cell proliferation and differentiation, according to the study of “Legume lectin FRIL preserves neural progenitor cells in suspension culture in vitro” by Yao H, Xie X, Li Y, Wang D, Han S, Shi S, Nan X, Bai C, Wang Y, Pei X.(2).

3. Antibody
In the investigation of the A galactose-specific lectin isolated from the seeds of Dolichos lablab, found that among a number of sugars tested for inhibitory activity of the lectin, galactose was found to be a potent inhibitor. Rabbit polyclonal antibody to the purified lectin specifically reacted with the lectin subunits in Western blot analysis and additionally, an antibody raised to the isolated 31 kDa subunit show reactivity with both the subunits, according to the study of “Affinity purification, physicochemical and immunological characterization of a galactose-specific lectin from the seeds of Dolichos lablab (Indian lablab beans)” by Latha VL, Rao RN, Nadimpalli SK.(3).

4. Physiological effects
In the evaluation of The effects of cooking on the dietary fiber (DF) content, which included resistant starch (RS) and nonstarch polysaccharides (NSP), of flours from Dolichos lablab seeds found that the method increased in the RS content of the cooked legume flours might have beneficial physiological effects for humans, according to the study of “Changes in the Dietary Fiber (Resistant Starch and Nonstarch Polysaccharides) Content of Cooked Flours Prepared from Three Chinese Indigenous Legume Seeds” by Cheung PC, Chau CF.(4).

5. Etc.

Side Effects
1. Bian Dou may inhibit the effect of trypsin and amylase and aggregation effect on human red blood cells, according to the artcle”Bian dou (bai bian dou), bian dou yi by Joe Hing Kwok Chu(a)
2. Do not use the herbif you are pregnant or breast feeding without permission of the related field specialist.
3. Do not use in intermittent chills and fevers or in cold or flu.
Etc.

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/10694493
(2) http://www.ncbi.nlm.nih.gov/pubmed/18695740
(3) http://www.ncbi.nlm.nih.gov/pubmed/16125971
(4) http://www.ncbi.nlm.nih.gov/pubmed/16125971
(a) http://alternativehealing.org/bian_dou.htm

Obesity and Obesity's complication - The association of Obesity on Carpal Tunnel Syndrome

Carpal Tunnel Syndrome is a condition of numbness, tingling, weakness, or muscle damage in the hand and fingers, as a result of the pressure on the median nerve.

The association of obesity on Carpal Tunnel Syndrome
1. According to the study of|The relationship of obesity, age, and carpal tunnel syndrome: more complex than was thought?" by Bland JD., posted in PubMed, researchers found that increased BMI is a significant independent risk factor for CTS in patients under the age of 63 years, but is less important in older patients. Patients over the age of 63 years have a different pattern of risk factors for CTS than younger patients. This suggests that CTS in the elderly population may have different underlying pathogenetic mechanisms.

2. In study of "Carpal tunnel syndrome" by Aroori S, Spence RA., posted inPubMed, researchers indicated that Carpal tunnel syndrome is one of the most common peripheral neuropathies. It affects mainly middle aged women. In the majority of patients the exact cause and pathogenesis of CTS is unclear. Although several occupations have been linked to increased incidence and prevalence of CTS the evidence is not clear. Occupational CTS is uncommon and it is essential to exclude all other causes particularly the intrinsic factors such as obesity before attributing it to occupation.

3. According to the study of "Hand syndromes associated with diabetes: impairments and obesity predict disability" by Redmond CL, Bain GI, Laslett LL, McNeil JD., posted in PubMed, researchers found that In adults with hand syndromes associated with diabetes, disability was related to impaired muscle function and carpal tunnel syndrome. Obesity and overall physical functioning influenced hand disability, particularly in women.

4. In abstract of the study of "Assessment of body mass index and hand anthropometric measurements as independent risk factors for carpal tunnel syndrome" by Sharifi-Mollayousefi A, Yazdchi-Marandi M, Ayramlou H, Heidari P, Salavati A, Zarrintan S, Sharifi-Mollayousefi A., posted in PubMed, researchers found that The mean values of BMI, wrist ratio and shape index were significantly higher in all CTS patients and females compared to controls, whereas in males only BMI and wrist ratio were higher. The patients in the mild severity subgroup had a significantly lower age and wrist ratio. BMI, wrist ratio and shape index were found to be independent risk factors of CTS development in all patients and females. Our study showed BMI, wrist ratio and shape index as independent risk factors for CTS. These findings are of potential anatomical and clinical importance and outline the risk factors of anatomical malfunction of the wrist in CTS.

5. According to the study of "Individual risk factors for carpal tunnel syndrome: an evaluation of body mass index, wrist index and hand anthropometric measurements" by Boz C, Ozmenoglu M, Altunayoglu V, Velioglu S, Alioglu Z., posted in PubMed, researchers concluded that Differences in the hand length/height ratio were not statistically significant in female and male CTS patients compared to their controls and it was not found to be an independent risk factor for CTS. Our study confirmed BMI as an independent risk factor for CTS in both genders. Hand and wrist anthropometrics were found to be independent risk factors for CTS in females, but not in males.

6. In abstract of the study of "Epidemiology of carpal tunnel syndrome in women of childbearing age. Findings in a large cohort study" by Vessey MP, Villard-Mackintosh L, Yeates D., posted in PubMed, researchers indicated that The most significant positive association between an existing disease and CTS was menstrual disorders (p=.001). Additional similar associations existed for orthopedic conditions and gastrointestinal tract symptoms. The relationships between CTS and OC use, menstrual disorders, and obesity may be related to pressure on the median nerve due to fat or edema near the carpal tunnel.

7. Etc.

Treatments of Obesity and Carpal Tunnel Syndrome
1. According to the study of "Medical and non-medical correlates of carpal tunnel syndrome in a Taiwan cohort of one million" by Tseng CH, Liao CC, Kuo CM, Sung FC, Hsieh DP, Tsai CH., posted in PubMed, researchers found that Patients were predominantly women (65.6% vs. 47.7% in the control group) and older (40 and above, 62.6% vs. 36.2%). Rheumatoid arthritis was found to be the most significant comorbidity associated with CTS, followed by gout, hypertension, diabetes, obesity, uremia, and acromegaly. For younger group age ≤39, the association of these comorbidities was stronger, and hypothyroidism and vitamin B(6) deficiency were additional comorbidities...., these disorders may aid in removing possible causes of CTS. This is the first report on the effect of aging on probable CTS risk factors. How factors associated with aging contribute to the development of CTS remains to be determined.

2. In a study of "Concurrent medical disease in work-related carpal tunnel syndrome" by, Atcheson SG, Ward JR, Lowe W., posted in PubMed, researchers concluded that Routine patient histories and record reviews are inadequate for proper evaluation of work-related CTS. Unrecognized medical diseases capable of causing CTS are common. Studies asserting an association between occupational hand usage and CTS are of questionable validity unless they prospectively account for confounding disease and obesity.

3. Etc.

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

Most Common Disease of plus: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Polymyalgia Arthritis (Rheumatica): The Individual herbs - Dan Shen

Musculoskeletal disorders (MSDs) are medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed(1).

Types of Musculo-Skeletal disorders in elder(2)
1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalgia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia

Polymyalgia Arthritis (Rheumatica)

Polymalgia Arthritis is defined as a condition a common inflammatory rheumatic disease which causes pain, stiffness and tenderness in large muscles, including muscles shoulders and pelvic girdle as a result of the presence of a synovitis in proximal joints and periarticular structures.

Treatments

B.2. Herbal and Traditional Chinese medicine
Herbal medicine from different cultures have been found effectively in reduced symptoms and treatment for patient with Polymyalagia Arthritis (Rheumatica), including
11. Dan Shen
Dan Shen with the pharmaceutical name of Radix Salvia miltiorrhizae, is a bitter and slightly cold herb, used mainly in traditional Chinese medicine for tonifying blood(494,236), such as getting rid of clot blood, invigorate blood, breakup blood stasis,... through its effects on liver and heart meridians.

According to Veterinary Herbal Medicine By Susan G. Wynn, Barbara Fougère, page 349. Dan Shen induced formation of dense callus and increased activity of osteoblasts of which enhanced the improvement of bone heeling(492,237). Certain studies found in Dan Shen (Salvia miltiorrhiza) in Medicine: Volume 2. Pharmacology ..., Volume 2 edited by Xijun Yan also supported the use of Dan Shen injection for treatment of arthritis because of its anti inflammatory effect(493,238).

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
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References

(492,236) Veterinary Herbal Medicine By Susan G. Wynn, Barbara Fougère, page 349.
(493,237) Dan Shen (Salvia miltiorrhiza) in Medicine: Volume 2. Pharmacology ..., Volume 2 edited by Xijun Yan
(493,238) Dan Shen (Salvia miltiorrhiza) in Medicine: Volume 2. Pharmacology ..., Volume 2 edited by Xijun Yan

The Holistic prevention, management and treatment of Polycystic Ovarian Syndrome: The Insulin resistance improvement and/or anti metabolic syndrome herbal Astragalus

Polycystic Ovarian Syndrome is defined as endocrinologic diseases among reproductive-age women caused by undeveloped follicles clumping on the ovaries that interferes with the function of the normal ovaries associated with a high risk for metabolic disorder(1) as resulting of enlarged ovaries(2), leading to hormone imbalance(excessive androgen and anti-müllerian hormone (AMH) )(1)(3)(4)(5), induced Hirsutism(6)(7), reproductive disorder(10(12)), risks of type 2 diabetes(9)(10)(11), metabolic syndrome(10)(12) and early cardiovascular disease(8)(13), acne(10)(14), endometrial cancer(18)(19),weight gain and obesity(15)(16)(17). The syndrome effects over 5% of women population or 1 in 20 women.
Unfortunately, according to studies, women with PCOs after the reproductive age, are associated to continuously increase risk of type II diabetes, with no increasingaltered glucose tolerance(20), CVD and hypertension(21).

The prevention and management In Herbal Medicine

Polycystic ovary syndrome (PCOS) is unpreventable in Western medicine. Early diagnosis and treatment may reduce risk of its complications, including infertility, metabolic syndrome, obesity, diabetes, cardiovascular diseases, stroke, etc.
Reduce fat intake less than 30% of total calories with a low proportion of saturated fat and high in fiber from predominantly low-glycaemic-index-carbohydrate foods for patients with PCOs(827a). Calorie intake should be distributed between several meals per day with restricted intake of snacks and drinks(828).

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

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The Insulin resistance improvement and/or antimetabolic syndrome herbs

Astragalus (Astragalus membranaceus)(1045)
Huang Qi or Bei Qi is also known as Astragalus root. The sweet herb has been used as diuretic agent and to lower blood pressure, increase blood pressure, lessens proteinuria, improve endurance, protect liver function, regulate blood sugar, etc. as it tonifies Qi, raises Yang, strengthens the Defensive-Qi and the Exterior, expels toxins, etc. by enhancing the functions of lung and spleen channels(1045).

Ingredients
1. Astragaloside I,
2. Astragaloside II,
3. Daucosterol,
3. Beta-sitosterol,
4. Palmitic acid
5. Astragalus saponin A,B,C
6. Astramenbrangenin
7. Kumatakenin,
8. Choline,
9. Betaine,
10. Folic acid
11. Calyxosin,
12. Formononetin,
13. Cycloastragenol,
14. Astragaloside III,IV
15. Antibacterial ingredient,
16. L-3-hydroxy-9-methoxpterocarpan
17. Etc.

Epidemiological studies showed that stragalus polysaccharides (APS) amelioratesinsulin resistance(1046)(1047) (IR) in rat cells and to elucidate the associated mechanisms, including increasing adiponectin secretion and reducing IL-6 secretion(1046), decreasing myostatin expression(1047), improving beta cell function(1049), regulating insulin signaling in insulin-resistant skeletal muscle(1047)(1048). insulin resistance related mRNA expression(1049), etc.
In metabolic syndrome, including increased body weight(1050), mild hypertension(1050), hyper insulinemia(1050), hyper triglyceridemia(1050), impaired glucose tolerance(1050)(1053) and impaired endothelium-dependent vasorelaxation(1050)(1051)(1052), astragaloside IV, a major constituent found in astragalus showed effectively in ameliorating metabolic syndrome(1050)(1052), probably through its antioxidant(1051), inhibition of abnormal TNF-alpha-induced intracellular free Ca(2+) accumulation in endothelial cells(1052), decreasing the elevated expression and activity in the skeletal muscles(1053).

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

References
(1) Adiposity and metabolic dysfunction in polycystic ovary syndrome by Sam S.(PubMed)
(2) A "kiss" before conception: triggering ovulation with kisspeptin-54 may improve IVF by Young SL.(PubMed)
(3.) Androgen hyperfunction and excessive heterosexual hair growth in women, with special attention to the polycystic ovarian syndrome by Lunde O1.(PubMed)
(4) Expression of anti-Müllerian hormone in letrozole rat model of polycystic ovary syndrome by Du DF1, Li XL, Fang F, Du MR.(PubMed)
(5) [Serum levels of anti-muller hormone in women with polycystic ovary syndromeand healthy women of reproductive age].[Article in Bulgarian] by Parahuleva N, Pehlivanov B, Orbecova M, Deneva T, Uchikova E.(PubMed)
(6) [Current opinions on the etiology and pathophysiology of hirsutism].[Article in Polish] by Krysiak R1, Kedzia A, Okopień B.(PubMed)
(7) The clinical evaluation of hirsutism by Somani N1, Harrison S, Bergfeld WF.(PubMed)
(8) Polycystic ovary syndrome and insulin: our understanding in the past, present and future by Mayer SB1, Evans WS, Nestler JE.(PubMed)
(9) Association of mean platelet volume with androgens and insulin resistance in nonobese patients with polycystic ovary syndrome by Dogan BA1, Arduc A2, Tuna MM1, Karakılıc E1, Dagdelen I1, Tutuncu Y1, Berker D1, Guler S1.(PubMed)
(10) Approach to the patient: contraception in women with polycystic ovary syndrome by Yildiz BO1.(PubMed)
(11) Polycystic ovarian syndrome (PCOS): a significant contributor to the overall burden of type 2 diabetes in women by Talbott EO1, Zborowski JV, Rager JR, Kip KE, Xu X, Orchard TJ.(PubMed)
(12) Prevalence of vitamin D deficiency in Slovak women with polycystic ovary syndrome and its relation to metabolic and reproductive abnormalities by Figurová J1, Dravecká I, Javorský M, Petríková J, Lazúrová I.(PubMed)
(13) Role of Insulin Sensitizers on Cardiovascular Risk Factors in Polycystic Ovarian Syndrome: A Meta-Analysis by Thethi TK1, Katalenich B2, Nagireddy P3, Chabbra P4, Kuhadiya N5, Fonseca V1.(PubMed)
(14) Acne in hirsute women by Lumezi BG1, Pupovci HL1, Berisha VL1, Goçi AU2, Gerqari A3.(PubMed)
(15) Obesity and polycystic ovary syndrome by Naderpoor N1, Shorakae S, Joham A, Boyle J, De Courten B, Teede HJ.(PubMed)
(16) Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan by Teede H1, Deeks A, Moran L.(PubMed)
(17) Metabolic Evidence of Diminished Lipid Oxidation in Women With Polycystic Ovary Syndrome. by Whigham LD1, Butz DE2, Dashti H3, Tonelli M3, Johnson LK1, Cook ME2, Porter WP4, Eghbalnia HR5, Markley JL6, Lindheim SR7, Schoeller DA8, Abbott DH9, Assadi-Porter FM10.(PubMed)
(18) Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis by Barry JA1, Azizia MM1, Hardiman PJ2.(PubMed)
(19) Risk of cancer among women with polycystic ovary syndrome: a Danish cohort study by Gottschau M1, Kjaer SK2, Jensen A1, Munk C1, Mellemkjaer L3.(PubMed)
(20) Polycystic ovary syndrome: metabolic consequences and long-term management by Carmina E1.(PubMed)
(21) Arterial stiffness is increased in asymptomatic nondiabetic postmenopausal women with a polycystic ovary syndrome phenotype by Armeni E1, Stamatelopoulos K, Rizos D, Georgiopoulos G, Kazani M, Kazani A, Kolyviras A, Stellos K, Panoulis K, Alexandrou A, Creatsa M, Papamichael C, Lambrinoudaki I.(PubMed)
(827a) Diet and nutrition in polycystic ovary syndrome (PCOS): pointers for nutritional management by Farshchi H, Rane A, Love A, Kennedy RL(PubMed)
(828) The optimal diet for women with polycystic ovary syndrome? by Marsh K, Brand-Miller J.(PubMed)
(1045) Huang Qi(Complementary and Alternative Healing University)
(1046) Amelioration of insulin resistance in rat cells by Astragalus polysaccharides and associated mechanisms by Liu H1, Bai J2, Weng X3, Wang T3, Li M1.(PubMed)
(1047) Astragalus polysaccharide suppresses skeletal muscle myostatin expression in diabetes: involvement of ROS-ERK and NF-κB pathways by Liu M1, Qin J2, Hao Y3, Liu M4, Luo J5, Luo T4, Wei L6.(PubMed)
(1048) Astragalus polysaccharide improves insulin sensitivity in KKAy mice: regulation of PKB/GLUT4 signaling in skeletal muscle by Liu M1, Wu K, Mao X, Wu Y, Ouyang J.(PubMed)
(1049) A refined-JinQi-JiangTang tablet ameliorates prediabetes by reducing insulin resistance and improving beta cell function in mice by Gao LH1, Liu Q1, Liu SN1, Chen ZY1, Li CN1, Lei L1, Sun SJ1, Li LY1, Liu JL1, Shen ZF2.(PubMed)
(1050) [Effects of Astragalus membranaceus and Potentilla discolor mixture oninsulin resistance and its related mRNA expressions in KKAy mice with type 2 diabetes].[Article in Chinese] by Zhang DM1, Lou LX, Wu AM, Lü XY, Hu ZJ, Zhang YH, Liu HF.(PubMed)
(1051) Astragaloside IV improves homocysteine-induced acute phase endothelial dysfunction via antioxidation by Qiu LH1, Xie XJ, Zhang BQ.(PubMed)
(1052) Effects of astragaloside IV on pathogenesis of metabolic syndrome in vitro by Xu ME1, Xiao SZ, Sun YH, Ou-Yang Y, Zheng XX.(PubMed)
(1053) Hypoglycemic effect of Astragalus polysaccharide and its effect on PTP1B by Wu Y1, Ou-Yang JP, Wu K, Wang Y, Zhou YF, Wen CY.(PubMed)