Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Garlic (Allium sativum)
Garlic (Allium sativum) is a species in the onion genus, belonging to family Amaryllidaceae, native to central Asia. It has been used popularly in traditional and Chinese medicine in treating common cold and flu to the Plague, blood pressure cholesterol levels, natural antibiotic, etc.
Health benefits
1. Anti cancer
In the evaluation of Garlic (Allium sativum) its consumption to reduce cancer risk and its extracts and components effectively block experimentally induced tumors found that allicin inhibited the growth of cancer cells of murine and human origin. Allicin induced the formation of apoptotic bodies, nuclear condensation and a typical DNA ladder in cancer cells. Furthermore, activation of caspases-3, -8 and -9 and cleavage of poly(ADP-ribose) polymerase were induced by allicin, according to "Allicin (from garlic) induces caspase-mediated apoptosis in cancer cells" by Oommen S, Anto RJ, Srinivas G, Karunagaran D.(1)
2. Colon cancer
In the identification of Allicin (diallyl thiosulfinate) of freshly crushed garlic extract and its effect against colon cancer found that allicin induces Nrf2-mediated luciferase transactivation activity. SiRNA knock down of Nrf2 significantly affected the capacity of allicin to inhibit HCT-116 proliferation. These results suggest that Nrf2 mediates the allicin-induced apoptotic death of colon cancer cells, according to "Allicin purified from fresh garlic cloves induces apoptosis in coloncancer cells via Nrf2" by Bat-Chen W, Golan T, Peri I, Ludmer Z, Schwartz B.(2)
3. Gastric cancer
In the classification of Diallyl disulfide (DADS) a organosulfur compound fromgarlic and it inhibits the proliferation of several tumor cells found that DADS decreases the viability of AGS cell lines and induces apoptosis in a dose-dependent manner. But the relationship of the anti-proliferative effect of DADS and related molecular changes were not clearly proportional to the concentration of DADS, according to "Induction of apoptosis with diallyl disulfide in AGS gastric cancer cell line" by Lee JE, Lee RA, Kim KH, Lee JH.(3)
4. Breast cancer
In the analyzing Garlic-derived organosulfur compounds (OSCs) and its antitumor effects found that Garlic constituent diallyl trisulfide (DATS) suppresses viability of cultured MCF-7 and MCF-12a cells respectively by decreasing the percent of cells in G(2)/M and inducing apoptotic cell death. DATS-induced apoptosis was markedly elevated in MCF-7 cells compared with MCF-12a cells and this was correlated with elevated levels of cyclin B1, according to "Garlic constituent diallyl trisulfide induced apoptosis in MCF7 human breast cancer cells" by Malki A, El-Saadani M, Sultan AS.(4)
5. Lung cancer
In the observation of the Garlic-derived organosulfur compounds (OSCs) and its protection against chemically induced pulmonary carcinogenesis found that garlicconstituent diallyl trisulfide (DATS) suppresses viability of cultured human lungcancer cell lines H358 (anon-small cell lung cancer cell line) and H460 (a large cell lung cancer cell line) by causing G2-M phase cell cycle arrest and apoptotic cell death. On the other hand, a normal human bronchial epithelial cell line BEAS-2B was significantly more resistant to growth inhibition and apoptosis induction by DATS compared with lung cancer cells, according to "Diallyl trisulfide selectively causes Bax- and Bak-mediated apoptosis in human lung cancer cells" by Xiao D, Zeng Y, Hahm ER, Kim YA, Ramalingam S, Singh SV.(5)
6. Blood pressure
In the assessment of garlic extract and its effect of hypertension. found that Agedgarlic extract was generally well tolerated and acceptability of trial treatment was high (92%) and aged garlic extract is superior to placebo in lowering systolic blood pressure similarly to current first line medications in patients with treated but uncontrolled hypertension, according to "Aged garlic extract lowers blood pressure in patients with treated but uncontrolled hypertension: a randomised controlled trial" by Ried K, Frank OR, Stocks NP.(6)
7. Atherosclerosis
In the demonstration of aged garlic extract therapy with supplements (AGE+S) and theirs effect on cardiovascular diseases found that CAC progression was significantly lower and TR significantly higher in the AGE+S compared to the placebo group after adjustment of cardiovascular risk factors (p<0.05). Total cholesterol, LDL-C, homocysteine, IgG and IgM autoantibodies to MDA-LDL and apoB-immune complexes were decreased, whereas HDL, OxPL/apoB, and Lp (a) were significantly increased in AGE+S to placebo and concluded that AGE+S is associated with a favorable improvement in oxidative biomarkers, vascular function, and reduced progression of atherosclerosis., according to "Aged garlicextract supplemented with B vitamins, folic acid and L-arginine retards the progression of subclinical atherosclerosis: a randomized clinical trial" by Budoff MJ, Ahmadi N, Gul KM, Liu ST, Flores FR, Tiano J, Takasu J, Miller E, Tsimikas S.(7)
8. Antifungal antitumor cytotoxicity and blood coagulability effects
In the identification of organosulfur compounds and theirs effects on cardiovascular diseases found that in vitro antifungal antitumor cytotoxicity and blood coagulability effects of steroid saponins from garlic and related Allium species are provided. Animal studies on the cholesterol-lowering effects of the saponin fractions from garlic are also summarized, according to "Saponins ingarlic as modifiers of the risk of cardiovascular disease" by .Matsuura H(8)
9. Cardiovascular diseases
In the review of the experimental and clinical studies confirm that the ancient experience with beneficial effects of garlic holds validity even in prevention ofcardiovascular disorders and other metabolic ills, indicated that Garlic-derived organic polysulfides are converted by erythrocytes into hydrogen sulfide which relaxes vascular smooth muscle, induces vasodilation of blood vessels, and significantly reduces blood pressure. There are data on potential ability of garlic to inhibit the rate of progression of coronary calcification. Garlic as a dietary component appears to hold promise to reduce the risk of cardiovascular disease(Fig. 2, Ref. 46), according to "Garlic (Allium sativum L.) and cardiovascular diseases" by Ginter E, Simko V.(9)
10. Antioxidant effects
In the study of the Extracts of aged fresh garlic that are aged over a prolonged period and its antioxidant effects found that the ability of AGE to protect against oxidant-induced disease, acute damage from aging, radiation and chemical exposure, and long-term toxic damage. Although additional observations are warranted in humans, compelling evidence supports the beneficial health effects attributed to AGE, i.e., reducing the risk of cardiovascular disease, stroke, cancer and aging, including the oxidant-mediated brain cell damage that is implicated in Alzheimer's disease, according to "Antioxidant health effects of aged garlicextract" by
Borek C.(10)
11. Diabetes
In the comparison of the effects of dietary ginger (Zingiber officinale) and garlic(Allium sativum) investigated in a type 2 diabetes model of rats found that that ginger and garlic are insulinotropic rather than hypoglycemic while overall anti-diabetic effects of ginger are better than those of garlic, at least in this experimental condition. Much better anti-diabetic effects of ginger and garlic may be obtained when feeding is with a normal rather than a HF-containing diet, according to "Comparative effects of dietary ginger (Zingiber officinale) andgarlic (Allium sativum) investigated in a type 2 diabetes model of rats" by Islam MS, Choi H.(11)
12. Common cold
In the searched from January 1966 to September 2009 combining the key wordscommon cold or influenza with echinacea, garlic, ginseng, probiotics, vitamin C, and zinc. Clinical trials and prospective studies found that for prevention, vitamin C demonstrated benefit in a large meta-analysis, with possibly increased benefit in patients subjected to cold stress. There is inconsistent evidence for Asian ginseng (Panax ginseng) and North American ginseng (Panax quinquefolius). Allicin was highly effective in 1 small trial. For treatment, Echinacea purpurea is the most consistently useful variety; it was effective in 5 of 6 trials. Zinc lozenges were effective in 5 of 9 trials, likely owing to dose and formulation issues. Overall, the evidence suggests no benefit from probiotics for prevention or treatment of thecommon cold, according to "Complementary and alternative medicine for prevention and treatment of the common cold" by Nahas R, Balla A.(12)
13. Tuberculosis
In the investigation of the garlic extracts and the increasing incidence of Mycobacterium tuberculosis (MTB) and particularly of multi-drug resistant tuberculosis (MDR-TB) found that Allium sativum offers a hope for developing alternative drugs. The involvement of traditional healers (TH) in the TB health management could facilitate the administration of garlic extracts to the infected patients, according to "The potential role of garlic (Allium sativum) against the multi-drug resistant tuberculosis pandemic: a review" by Dini C, Fabbri A, Geraci A.(13)
14. Etc.
Side Effects
1. Do not use the herb if you have ulcer
2. Raw garlic or overdoses may cause irritation of or even damage to the digestive tract
3. PLease consult with your doctor before taking garlic if you are taking blood thiner medication
4. It may cause allergic effect to some people
5. Etc.
Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/14757128
(2) http://www.ncbi.nlm.nih.gov/pubmed/20924970
(3) http://www.ncbi.nlm.nih.gov/pubmed/22066106
(4) http://www.ncbi.nlm.nih.gov/pubmed/19823037
(5) http://www.ncbi.nlm.nih.gov/pubmed/18800351
(6) http://www.ncbi.nlm.nih.gov/pubmed/20594781
(7) http://www.ncbi.nlm.nih.gov/pubmed/19573556
(8) http://www.ncbi.nlm.nih.gov/pubmed/11238805
(9) http://www.ncbi.nlm.nih.gov/pubmed/21033626
(10) http://www.ncbi.nlm.nih.gov/pubmed/11238807
(11) http://www.ncbi.nlm.nih.gov/pubmed/18361751
(12) http://www.ncbi.nlm.nih.gov/pubmed/21322286
(13) http://www.ncbi.nlm.nih.gov/pubmed/22194081
Friday, June 17, 2016
Most Common Diseases of Men of 50Plus - Erectile Dysfunction Prevention and Treatment - Herbal Ginseng
Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
In the finding of a whole food and herb, comparing to the presently pharmaceutical medicine in use with little or no adverse effect(4), scientific communities have been looking into herbal ginseng which has been used extensively in traditional Chinese medicine for treatment of sexual dysfunction in both sexes.
According to statistic, in US alone, more than18 Million Men over 20 of ages are affected by Erectile Dysfunction and approximately 5% of 40-year-old men and between 15% and 25% of 65-year-old men experience ED on a long-term basis (National Institutes of Health). Astonishingly, lifetime use of ED medications was reported by 24% of men. Almost 69% of ED medication users reported obtaining ED medications from a physician. Fifty-nine percent of ED medication users reported taking the medications to enhance their sexual experience rather than to treat ED, which was marginally associated with stimulant use. according to Department of Veterans Affairs Puget Sound Health Care System, Seattle(1).
The comparison of the effect of erectile dysfunction with diabetes and men with erectile dysfunction due to other causes study indicated that the diseases not only affect Sexual Experience-Psychological Impact domains but also Emotional Life-Psychological Impact domain(2).
Ginseng, the King of Chinese herb, according to the literature in Chinese medicine found by Emperor Shen-Nung, the second of China's mythical emperors (3500-2600 BCE), through his treatise 'Shen Nung Benchau Jing', expressed the efficacy of herbal ginseng well being as a resemblance of human form and its rejuvenative and aphrodisiac properties. The use of ginseng for erectile dysfunction by EmperorShen-Nung was unique for its time. It continues to hold parallels as a modern-day herbal aphrodisiac 5000 years on(3).
Panax notoginseng saponins (PNS), a major ingredient found in ginseng, in the study of erectile dysfunction and the underlying mechanism by using a rat diabeticerectile dysfunction model, showed a positive effect in deduction of oxidative stress cause of erectile dysfunction and restoration of functions of endothelial cells and smooth muscle cells in the penis, through reduced level of malondialdehyde and increased levels of superoxide dismutase, glutathione and Akt(5) and possibly via the NO/cGMP pathway(6).
In root-derived Korean red ginseng (KRG; Panax ginseng) study, researchers at the Yonsei University College of Medicine, found that GB0710 relaxes the penile corpus cavernosum smooth muscle (CCSM), through induced intracellular NO production in human microvascular endothelial cells by N(G)-monomethyl-L-arginine inhibition(7).
In a 119 men with mild-to-moderate ED participated in a multicenter, randomized, double-blind, parallel, placebo-controlled clinical study, oral administration of the SKGB extract improved all domains of sexual function(8)(9).
According to Chinese medicine, Herbal ginseng has been prescribed over 5000 years of history to promote yang and to improve cardiac function, short of breath, blood pressure. Panax ginseng can generates fluids and reduce thirst, to treat anxiety, insomnia, dizziness/headache, forgetfulness, impotence, diabetes, bleeding in the vagina not during period, etc.
Dr. Shergis JL and the researcher team at the School of Health Sciences and Health Innovations Research Institute-HIRi, RMIT University, told PubMed " Overall, the quality of Panax ginseng (andomized controlled trials ) RCT methodology has improved since the CONSORT checklist was introduced. However, more can be done to improve the methodological quality of, and reporting in, RCTs"(10)
But the use of herbal medicine in treating erectile dysfunction should be taken with care. Dr Ho CC and Dr. Tan HM. said" Many herbal therapies appear to have potential benefits, and similarly, the health risks of various phytotherapeutic compounds need to be elucidated. Properly designed human trials should be worked out and encouraged to determine the efficacy and safety of potential phytotherapies"(11). As the herb has shown mild adverse events, such as dyspepsia, hot flash, insomnia, and constipation in dose depending manner(12).
Chinese Food Therapy
The Best Way to prevent, treat your disease, including Erectile Dysfunction
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Reference
(1) Erectile dysfunction medication use among men seeking substance abuse treatment by Horvath KJ, Calsyn DA, Terry C, Cotton A.(PubMed)
(2) Do impotent men with diabetes have more severe erectile dysfunction and worse quality of life than the general population of impotent patients? Results from the Exploratory Comprehensive Evaluation of Erectile Dysfunction (ExCEED) database by Penson DF, Latini DM, Lubeck DP, Wallace KL, Henning JM, Lue TF; Comprehensive Evaluation of Erectile Dysfunction (ExCEED) database(PubMed)
(3) The history of ginseng in the management of erectile dysfunction in ancient China (3500-2600 BCE) by Nair R, Sellaturay S, Sriprasad S.(PubMed)
(4) Erectile dysfunction: Viagra and other oral medications(Mayo clinic)
(5) Panax notoginseng Saponins Improve Erectile Function through Attenuation of Oxidative Stress, Restoration of Akt Activity and Protection of Endothelial and Smooth Muscle Cells in Diabetic Rats with Erectile Dysfunction by Li H, He WY, Lin F, Gou X.(PubMed)
(6) Panax notoginseng saponins improve the erectile dysfunction in diabetic rats by protecting the endothelial function of the penile corpus cavernosum by Lin F, Gou X.(PubMed)
(7) Effects of Korean ginseng berry extract (GB0710) on penile erection: evidence from in vitro and in vivo studies by Cho KS, Park CW, Kim CK, Jeon HY, Kim WG, Lee SJ, Kim YM, Lee JY, Choi YD.(PubMed)
(8) Effects of Korean ginseng berry extract on sexual function in men with erectile dysfunction: a multicenter, placebo-controlled, double-blind clinical study by Choi YD, Park CW, Jang J, Kim SH, Jeon HY, Kim WG, Lee SJ, Chung WS(PubMed)
(9) Effects of tissue-cultured mountain ginseng (Panax ginseng CA Meyer) extract on male patients with erectile dysfunction by Kim TH, Jeon SH, Hahn EJ, Paek KY, Park JK, Youn NY, Lee HL.(PubMed)
(10) Quality and risk of bias in Panax ginseng randomized controlled trials: a review by Shergis JL, Zhang AL, Zhou W, Xue CC.(PubMed)
(11) Rise of herbal and traditional medicine in erectile dysfunction management by Ho CC, Tan HM.(PubMed)
(12) Safety and tolerability of Panax ginseng root extract: a randomized, placebo-controlled, clinical trial in healthy Korean volunteers by Lee NH, Yoo SR, Kim HG, Cho JH, Son CG.(PubMed)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
In the finding of a whole food and herb, comparing to the presently pharmaceutical medicine in use with little or no adverse effect(4), scientific communities have been looking into herbal ginseng which has been used extensively in traditional Chinese medicine for treatment of sexual dysfunction in both sexes.
According to statistic, in US alone, more than18 Million Men over 20 of ages are affected by Erectile Dysfunction and approximately 5% of 40-year-old men and between 15% and 25% of 65-year-old men experience ED on a long-term basis (National Institutes of Health). Astonishingly, lifetime use of ED medications was reported by 24% of men. Almost 69% of ED medication users reported obtaining ED medications from a physician. Fifty-nine percent of ED medication users reported taking the medications to enhance their sexual experience rather than to treat ED, which was marginally associated with stimulant use. according to Department of Veterans Affairs Puget Sound Health Care System, Seattle(1).
The comparison of the effect of erectile dysfunction with diabetes and men with erectile dysfunction due to other causes study indicated that the diseases not only affect Sexual Experience-Psychological Impact domains but also Emotional Life-Psychological Impact domain(2).
Ginseng, the King of Chinese herb, according to the literature in Chinese medicine found by Emperor Shen-Nung, the second of China's mythical emperors (3500-2600 BCE), through his treatise 'Shen Nung Benchau Jing', expressed the efficacy of herbal ginseng well being as a resemblance of human form and its rejuvenative and aphrodisiac properties. The use of ginseng for erectile dysfunction by EmperorShen-Nung was unique for its time. It continues to hold parallels as a modern-day herbal aphrodisiac 5000 years on(3).
Panax notoginseng saponins (PNS), a major ingredient found in ginseng, in the study of erectile dysfunction and the underlying mechanism by using a rat diabeticerectile dysfunction model, showed a positive effect in deduction of oxidative stress cause of erectile dysfunction and restoration of functions of endothelial cells and smooth muscle cells in the penis, through reduced level of malondialdehyde and increased levels of superoxide dismutase, glutathione and Akt(5) and possibly via the NO/cGMP pathway(6).
In root-derived Korean red ginseng (KRG; Panax ginseng) study, researchers at the Yonsei University College of Medicine, found that GB0710 relaxes the penile corpus cavernosum smooth muscle (CCSM), through induced intracellular NO production in human microvascular endothelial cells by N(G)-monomethyl-L-arginine inhibition(7).
In a 119 men with mild-to-moderate ED participated in a multicenter, randomized, double-blind, parallel, placebo-controlled clinical study, oral administration of the SKGB extract improved all domains of sexual function(8)(9).
According to Chinese medicine, Herbal ginseng has been prescribed over 5000 years of history to promote yang and to improve cardiac function, short of breath, blood pressure. Panax ginseng can generates fluids and reduce thirst, to treat anxiety, insomnia, dizziness/headache, forgetfulness, impotence, diabetes, bleeding in the vagina not during period, etc.
Dr. Shergis JL and the researcher team at the School of Health Sciences and Health Innovations Research Institute-HIRi, RMIT University, told PubMed " Overall, the quality of Panax ginseng (andomized controlled trials ) RCT methodology has improved since the CONSORT checklist was introduced. However, more can be done to improve the methodological quality of, and reporting in, RCTs"(10)
But the use of herbal medicine in treating erectile dysfunction should be taken with care. Dr Ho CC and Dr. Tan HM. said" Many herbal therapies appear to have potential benefits, and similarly, the health risks of various phytotherapeutic compounds need to be elucidated. Properly designed human trials should be worked out and encouraged to determine the efficacy and safety of potential phytotherapies"(11). As the herb has shown mild adverse events, such as dyspepsia, hot flash, insomnia, and constipation in dose depending manner(12).
Chinese Food Therapy
The Best Way to prevent, treat your disease, including Erectile Dysfunction
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Reference
(1) Erectile dysfunction medication use among men seeking substance abuse treatment by Horvath KJ, Calsyn DA, Terry C, Cotton A.(PubMed)
(2) Do impotent men with diabetes have more severe erectile dysfunction and worse quality of life than the general population of impotent patients? Results from the Exploratory Comprehensive Evaluation of Erectile Dysfunction (ExCEED) database by Penson DF, Latini DM, Lubeck DP, Wallace KL, Henning JM, Lue TF; Comprehensive Evaluation of Erectile Dysfunction (ExCEED) database(PubMed)
(3) The history of ginseng in the management of erectile dysfunction in ancient China (3500-2600 BCE) by Nair R, Sellaturay S, Sriprasad S.(PubMed)
(4) Erectile dysfunction: Viagra and other oral medications(Mayo clinic)
(5) Panax notoginseng Saponins Improve Erectile Function through Attenuation of Oxidative Stress, Restoration of Akt Activity and Protection of Endothelial and Smooth Muscle Cells in Diabetic Rats with Erectile Dysfunction by Li H, He WY, Lin F, Gou X.(PubMed)
(6) Panax notoginseng saponins improve the erectile dysfunction in diabetic rats by protecting the endothelial function of the penile corpus cavernosum by Lin F, Gou X.(PubMed)
(7) Effects of Korean ginseng berry extract (GB0710) on penile erection: evidence from in vitro and in vivo studies by Cho KS, Park CW, Kim CK, Jeon HY, Kim WG, Lee SJ, Kim YM, Lee JY, Choi YD.(PubMed)
(8) Effects of Korean ginseng berry extract on sexual function in men with erectile dysfunction: a multicenter, placebo-controlled, double-blind clinical study by Choi YD, Park CW, Jang J, Kim SH, Jeon HY, Kim WG, Lee SJ, Chung WS(PubMed)
(9) Effects of tissue-cultured mountain ginseng (Panax ginseng CA Meyer) extract on male patients with erectile dysfunction by Kim TH, Jeon SH, Hahn EJ, Paek KY, Park JK, Youn NY, Lee HL.(PubMed)
(10) Quality and risk of bias in Panax ginseng randomized controlled trials: a review by Shergis JL, Zhang AL, Zhou W, Xue CC.(PubMed)
(11) Rise of herbal and traditional medicine in erectile dysfunction management by Ho CC, Tan HM.(PubMed)
(12) Safety and tolerability of Panax ginseng root extract: a randomized, placebo-controlled, clinical trial in healthy Korean volunteers by Lee NH, Yoo SR, Kim HG, Cho JH, Son CG.(PubMed)
The Obesity' Research and Studies - Identifying predictive variables for long-term weight change after participation in a weight loss program
Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Obesity is a medical condition of excess body fat accumulated overtime, while overweight is a condition of excess body weight relatively to the height. According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered over weight, while a BMI of over 30 is an indication of obesity. According to the statistic, 68% of American population are either overweight or obese.
You can calculate your BMI index BMI= weight (kg)/ height (m2)
In the investigation of whether there was an association between weight change and 31 independent variables among obese persons 2 years after a weight lossprogram, conducted by Marshall University School of Medicine,(1) found that Of the 31 independent variables, 16 were significantly predictive of weight change. The adjusted R2 for the entire group of 16 variables was .379. Thus, 37.9% of the variance was explained by the joint efforts of the 16 variables. Eight variables with an adjusted R2 of .371 (accounting for 37.1% of the variance) were most important: feeling in control of eating habits, percentage over ideal body weight at enrollment, percentage of weight lost during the 8-week treatment, frequency ofweight measurement, increase in physical activity, frequency of eating in response to emotions, number of pounds gained before subject resumed diet, and occupation
Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
(1) "Identifying predictive variables for long-term weight change after participation in a weight loss program" by Lavery MA, Loewy JW.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Obesity is a medical condition of excess body fat accumulated overtime, while overweight is a condition of excess body weight relatively to the height. According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered over weight, while a BMI of over 30 is an indication of obesity. According to the statistic, 68% of American population are either overweight or obese.
You can calculate your BMI index BMI= weight (kg)/ height (m2)
In the investigation of whether there was an association between weight change and 31 independent variables among obese persons 2 years after a weight lossprogram, conducted by Marshall University School of Medicine,(1) found that Of the 31 independent variables, 16 were significantly predictive of weight change. The adjusted R2 for the entire group of 16 variables was .379. Thus, 37.9% of the variance was explained by the joint efforts of the 16 variables. Eight variables with an adjusted R2 of .371 (accounting for 37.1% of the variance) were most important: feeling in control of eating habits, percentage over ideal body weight at enrollment, percentage of weight lost during the 8-week treatment, frequency ofweight measurement, increase in physical activity, frequency of eating in response to emotions, number of pounds gained before subject resumed diet, and occupation
Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
(1) "Identifying predictive variables for long-term weight change after participation in a weight loss program" by Lavery MA, Loewy JW.
Obesity and Obesity's complication - The association of Obesity on Poor Healing of Wounds
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Obesity is a medical condition of excess body fat accumulated overtime, while overweight is a condition of excess body weight relatively to the height. According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered over weight, while a BMI of over 30 is an indication of obesity. According to the statistic, 68% of American population are either overweight or obese.
You can calculate your BMI index BMI= weight (kg)/ height (m2)
Poor Healing of Wounds are defined as a condition of the inability of the body to heal the wound quickly. It may be caused by the physical state of the wound or certain health effects, such as obesity, diabetes, abnormal coagulation. etc.
The association of Obesity on Poor Healing of Wounds
1. According to the study of "Dysfunctional γδ T Cells Contribute to Impaired Keratinocyte Homeostasis in Mouse Models of Obesity" by Taylor KR, Costanzo AE, Jameson JM. (Source from Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, USA.,J Invest Dermatol. 2011 Aug 11. doi: 10.1038/jid.2011.241. [Epub ahead of print]), posted in PubMed,, researchers found that These studies reveal that γδ T cells are unable to regulate keratinocyte homeostasis in obesity and that the obese environment further impairs skin structure by altering cell-cell adhesion. Together, impaired keratinocyte homeostasis and epidermal barrier function through direct and indirect mechanisms result in susceptibility to skin complications, chronicwounds, and infection.
2. In a study of "Gammadelta T cells are reduced and rendered unresponsive by hyperglycemia and chronic TNFalpha in mouse models of obesity and metabolic disease" by Taylor KR, Mills RE, Costanzo AE, Jameson JM. (Source from Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America, PLoS One. 2010 Jul 2;5(7):e11422.), posted in PubMed, researchers filed in abstract that Skin gammadelta T cells that overcome this hyperglycemic state are unresponsive to epithelial cell damage due to chronic inflammatory mediators, including TNFalpha. Cytokine and growth factor production at the site of tissue damage was partially restored by administering neutralizing TNFalpha antibodies in vivo. Thus, metabolic disease negatively impacts homeostasis and functionality of skin gammadelta T cells, rendering host defense mechanisms vulnerable to injury and infection.
3. In an abstract of the study of "Wound healing in mice with high-fat diet- or ob gene-induced diabetes-obesity syndromes: a comparative study" by Seitz O, Schürmann C, Hermes N, Müller E, Pfeilschifter J, Frank S, Goren I. (Source from Pharmazentrum Frankfurt/ZAFES, Institut für Allgemeine Pharmakologie und Toxikologie, Klinikum der Johann Wolfgang Goethe-Universität, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany), posted in PubMed, researchers found that by contrast to impaired wound conditions in ob/ob mice, late wounds of HFD mice did not develop a chronic inflammatory state and were epithelialized after 11 days of repair. Thus, only genetically obese and diabetic ob/ob mice finally developed chronic wounds and therefore represent a better suited experimental model to investigate diabetes-induced wound healing disorders.
4. According to the study of "Impaired Laparotomy Wound Healing in Obese Rats" by Xing L, Culbertson EJ, Wen Y, Robson MC, Franz MG. (Source from Department of Surgery, University of Michigan, 2124F Taubman Center, 1500 East Medical Center Drive, Ann Arbor, MI, 48109-0331, USA), posted in PubMed, researchers indicated that laparotomy wound healing is impaired in obese rats. The recovery of laparotomy wound strength is delayed due to abnormal collagen maturation and remodeling, possibly due to a defect in fibroblast function. Strategies to improve outcomes for laparotomy wound healing in obese patients should include correcting the wound healing defect, possibly with growth factor or cell therapy.
5. Etc.
Treatments of Obesity and Poor Healing of Wounds
1. According to the abstract of the study of "Zucker diabetic fatty rat: a new model of impaired cutaneous wound repair with type II diabetes mellitus andobesity" by Slavkovsky R, Kohlerova R, Tkacova V, Jiroutova A, Tahmazoglu B, Velebny V, Rezačová M, Sobotka L, Kanta J. (Source from Laboratory of Wound Healing, CPN, Dolni Dobrouc, Czech Republic. rastik@gmail.com, Wound Repair Regen. 2011 Jul;19(4):515-25. doi: 10.1111/j.1524-475X.2011.00703.x. Epub 2011 Jun 7.), posted in PubMed, researcher indicated that The concentration of hydroxyproline in the GT of diabetic animals was significantly decreased to about one half when compared with the nondiabetic controls. The expression of interleukin-6, myeloperoxidase, stromelysin-1, and collagenase-3 was increased in the GT of diabetic rats on Day 10, while the expression of type I collagen and elastin was decreased. Taken together, Zucker diabetic fatty rats exhibited impairments in wound-size reduction, inflammatory response, tissue organization, and connective tissue turnover and are thus proposed as a new model for studying impaired repair.
2. According to the study of "Systemically and topically supplemented leptin fails to reconstitute a normal angiogenic response during skin repair in diabetic ob/ob mice" by Stallmeyer B, Pfeilschifter J, Frank S. (Source from Centre of Pharmacology, University Hospital, Johann Wolfgang Goethe University, Frankfurt am Main, Germany), posted in PubMed, researchers filed in abstracted that These data suggest that leptin reconstituted epithelial expression of VEGF during skin repair in ob/ob mice but failed to improve wound angiogenesis in the granulation tissue. Thus, the accelerated wound closure observed in leptin-supplemented ob/ob mice is not coupled to an improved wound angiogenesis.
3. Etc.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Obesity is a medical condition of excess body fat accumulated overtime, while overweight is a condition of excess body weight relatively to the height. According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered over weight, while a BMI of over 30 is an indication of obesity. According to the statistic, 68% of American population are either overweight or obese.
You can calculate your BMI index BMI= weight (kg)/ height (m2)
Poor Healing of Wounds are defined as a condition of the inability of the body to heal the wound quickly. It may be caused by the physical state of the wound or certain health effects, such as obesity, diabetes, abnormal coagulation. etc.
The association of Obesity on Poor Healing of Wounds
1. According to the study of "Dysfunctional γδ T Cells Contribute to Impaired Keratinocyte Homeostasis in Mouse Models of Obesity" by Taylor KR, Costanzo AE, Jameson JM. (Source from Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, USA.,J Invest Dermatol. 2011 Aug 11. doi: 10.1038/jid.2011.241. [Epub ahead of print]), posted in PubMed,, researchers found that These studies reveal that γδ T cells are unable to regulate keratinocyte homeostasis in obesity and that the obese environment further impairs skin structure by altering cell-cell adhesion. Together, impaired keratinocyte homeostasis and epidermal barrier function through direct and indirect mechanisms result in susceptibility to skin complications, chronicwounds, and infection.
2. In a study of "Gammadelta T cells are reduced and rendered unresponsive by hyperglycemia and chronic TNFalpha in mouse models of obesity and metabolic disease" by Taylor KR, Mills RE, Costanzo AE, Jameson JM. (Source from Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America, PLoS One. 2010 Jul 2;5(7):e11422.), posted in PubMed, researchers filed in abstract that Skin gammadelta T cells that overcome this hyperglycemic state are unresponsive to epithelial cell damage due to chronic inflammatory mediators, including TNFalpha. Cytokine and growth factor production at the site of tissue damage was partially restored by administering neutralizing TNFalpha antibodies in vivo. Thus, metabolic disease negatively impacts homeostasis and functionality of skin gammadelta T cells, rendering host defense mechanisms vulnerable to injury and infection.
3. In an abstract of the study of "Wound healing in mice with high-fat diet- or ob gene-induced diabetes-obesity syndromes: a comparative study" by Seitz O, Schürmann C, Hermes N, Müller E, Pfeilschifter J, Frank S, Goren I. (Source from Pharmazentrum Frankfurt/ZAFES, Institut für Allgemeine Pharmakologie und Toxikologie, Klinikum der Johann Wolfgang Goethe-Universität, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany), posted in PubMed, researchers found that by contrast to impaired wound conditions in ob/ob mice, late wounds of HFD mice did not develop a chronic inflammatory state and were epithelialized after 11 days of repair. Thus, only genetically obese and diabetic ob/ob mice finally developed chronic wounds and therefore represent a better suited experimental model to investigate diabetes-induced wound healing disorders.
4. According to the study of "Impaired Laparotomy Wound Healing in Obese Rats" by Xing L, Culbertson EJ, Wen Y, Robson MC, Franz MG. (Source from Department of Surgery, University of Michigan, 2124F Taubman Center, 1500 East Medical Center Drive, Ann Arbor, MI, 48109-0331, USA), posted in PubMed, researchers indicated that laparotomy wound healing is impaired in obese rats. The recovery of laparotomy wound strength is delayed due to abnormal collagen maturation and remodeling, possibly due to a defect in fibroblast function. Strategies to improve outcomes for laparotomy wound healing in obese patients should include correcting the wound healing defect, possibly with growth factor or cell therapy.
5. Etc.
Treatments of Obesity and Poor Healing of Wounds
1. According to the abstract of the study of "Zucker diabetic fatty rat: a new model of impaired cutaneous wound repair with type II diabetes mellitus andobesity" by Slavkovsky R, Kohlerova R, Tkacova V, Jiroutova A, Tahmazoglu B, Velebny V, Rezačová M, Sobotka L, Kanta J. (Source from Laboratory of Wound Healing, CPN, Dolni Dobrouc, Czech Republic. rastik@gmail.com, Wound Repair Regen. 2011 Jul;19(4):515-25. doi: 10.1111/j.1524-475X.2011.00703.x. Epub 2011 Jun 7.), posted in PubMed, researcher indicated that The concentration of hydroxyproline in the GT of diabetic animals was significantly decreased to about one half when compared with the nondiabetic controls. The expression of interleukin-6, myeloperoxidase, stromelysin-1, and collagenase-3 was increased in the GT of diabetic rats on Day 10, while the expression of type I collagen and elastin was decreased. Taken together, Zucker diabetic fatty rats exhibited impairments in wound-size reduction, inflammatory response, tissue organization, and connective tissue turnover and are thus proposed as a new model for studying impaired repair.
2. According to the study of "Systemically and topically supplemented leptin fails to reconstitute a normal angiogenic response during skin repair in diabetic ob/ob mice" by Stallmeyer B, Pfeilschifter J, Frank S. (Source from Centre of Pharmacology, University Hospital, Johann Wolfgang Goethe University, Frankfurt am Main, Germany), posted in PubMed, researchers filed in abstracted that These data suggest that leptin reconstituted epithelial expression of VEGF during skin repair in ob/ob mice but failed to improve wound angiogenesis in the granulation tissue. Thus, the accelerated wound closure observed in leptin-supplemented ob/ob mice is not coupled to an improved wound angiogenesis.
3. Etc.
Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Traditional Chinese Medicine Herbal Therapy - Popular Chinese Herbs – Bo Ye (Cacumen Biotae Orientalis)
Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Bo Ye (Cacumen Biotae Orientalis)
Bo Ye (Ce Bai Ye, Bai Ye) is also known as biota orientalis leaves. The bitter and cool herb has been used in TCM to stop bleeding, harmonize blood, inhibit cough ad as an anti-bacterial, anti-inflammatory agent. The seed is laxative and sedative and used to treat palpitations, insomnia, nervous disorders and constipation in the seniors as it cleans heat, stops bleeding, harmonizes blood, etc. by promoting the function of heart, liver, large intestine channels.
Ingredients
1. Fenchone
2. Bornyl
3. Bronyl acetate
4. Juniperic acid
5. Quercetin
6. Myricetin
7. Kaempferol
8. Hinokiflavone
9. Etc.
Health benefits
2. Anti-allergic effect
Lambertianic acid, a bioactive diterpene found in the leaves of Thuja orientalis has exerted its effect on the allergic mediatorsthe by inhibiting the production of interleukin-6 (IL-6), PGD(2) and LTC(4), the expression of COX-2 and the degranulation of β-hexosaminidase in the (phorbol 12-myristate 13-acetate) PMA plus calcimycin-induced bone marrow-derived mast cell (BMMCs), according to the study of “Anti-allergic effect of lambertianic acid from Thuja orientalis in mouse bone marrow-derived mast cells” by Chae HS, Chin YW.(1).
3. Anti-inflammatory effect
15-methoxypinusolidic acid (15-MPA) isolated from Biota orientalis has demonstrated anti-inflammatory effect of the compound on microglial cells by inhibiting LPS-induced (inducible nitric oxide synthase)iNOS expression and (nitric oxide)NO production, independent on MAPK and NF-kappaB, according to the study of “A pinusolide derivative, 15-methoxypinusolidic acid from Biota orientalis inhibits inducible nitric oxide synthase in microglial cells: implication for a potential anti-inflammatory effect” byChoi Y, Moon A, Kim YC.(3).
4. Neuronal damage
Water extract, pinusolidic acid of Biota orientalis has shown a potent inhibitory effect on platelet activating factor (PAF) binding to rabbit platelets using [ (3)H]PAF, rsutling in lessening the risk of neuronal damage, according to the study of “Pinusolidic acid: a platelet-activating factor inhibitor from Biota orientalis” by Yang HO, Han BH.(4).
5. Coagulation
Quercitrin of Bo Ye has exerted the activity of promotes hemostasis or stop bleeding, according to the study of “Studies on the antihemostatic substances in herbs classified as hemostatics in traditional Chinese medicine. I. On the antihemostatic principles in Sophora japonica L” byH Ishida, T Umino, K Tsuji, T Kosuge(5).
6. Gout and hyperuricemia
Biota orientalis (BO) extract and its flavonoid constituents quercetin and rutin has exerted inhibitory actions on the xanthine dehydrogenase/xanthine oxidase (XDH/XO) activities, according to the study of “Effects of Biota orientalis extract and its flavonoid constituents, quercetin and rutin on serum uric acid levels in oxonate-induced mice and xanthine dehydrogenase and xanthine oxidase activities in mouse liver” by Ji Xiao Zhu, Ying Wang, Ling Dong Kong , Cheng Yang, Xin Zhang(6).
7. Etc.
Side effects
1. Long term intake and overdoses can cause dizziness, nausea, vomiting. etc.
2. Do not use the herb, if you are pregnant or breast feeding with no permission of related field specialist.
3. Etc.
Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Sources
(1) http://www.springerlink.com/content/g056714255k70077/
(2) http://www.ncbi.nlm.nih.gov/pubmed/21854102
(3) http://www.ncbi.nlm.nih.gov/pubmed/18328446
(4) http://www.ncbi.nlm.nih.gov/pubmed/17253221
(5) http://sc.chat-shuffle.net/paper/uid:110003627815
(6) http://www.sciencedirect.com/science/article/pii/S037887410400162X
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Bo Ye (Cacumen Biotae Orientalis)
Bo Ye (Ce Bai Ye, Bai Ye) is also known as biota orientalis leaves. The bitter and cool herb has been used in TCM to stop bleeding, harmonize blood, inhibit cough ad as an anti-bacterial, anti-inflammatory agent. The seed is laxative and sedative and used to treat palpitations, insomnia, nervous disorders and constipation in the seniors as it cleans heat, stops bleeding, harmonizes blood, etc. by promoting the function of heart, liver, large intestine channels.
Ingredients
1. Fenchone
2. Bornyl
3. Bronyl acetate
4. Juniperic acid
5. Quercetin
6. Myricetin
7. Kaempferol
8. Hinokiflavone
9. Etc.
Health benefits
1. Liver fibrosis
Totarol and isopimara-8(14),15-dien-19-oic acid from the 90% methanolic fraction of Biota orientalis leaves have exerted the dramatically reduced cell proliferation of liver fibrosis, according to the study of ” Antifibrotic activity of diterpenes fromBiota orientalis leaves on hepatic stellate cell” by Mi Kyeong Lee, Hyekyung Yang, Jeong Seon Yoon, Eun Ju Jeong, Do Yoon Kim, Na Ry Ha, Sang Hyun Sung and Young Choong Kim(1).
Totarol and isopimara-8(14),15-dien-19-oic acid from the 90% methanolic fraction of Biota orientalis leaves have exerted the dramatically reduced cell proliferation of liver fibrosis, according to the study of ” Antifibrotic activity of diterpenes fromBiota orientalis leaves on hepatic stellate cell” by Mi Kyeong Lee, Hyekyung Yang, Jeong Seon Yoon, Eun Ju Jeong, Do Yoon Kim, Na Ry Ha, Sang Hyun Sung and Young Choong Kim(1).
2. Anti-allergic effect
Lambertianic acid, a bioactive diterpene found in the leaves of Thuja orientalis has exerted its effect on the allergic mediatorsthe by inhibiting the production of interleukin-6 (IL-6), PGD(2) and LTC(4), the expression of COX-2 and the degranulation of β-hexosaminidase in the (phorbol 12-myristate 13-acetate) PMA plus calcimycin-induced bone marrow-derived mast cell (BMMCs), according to the study of “Anti-allergic effect of lambertianic acid from Thuja orientalis in mouse bone marrow-derived mast cells” by Chae HS, Chin YW.(1).
3. Anti-inflammatory effect
15-methoxypinusolidic acid (15-MPA) isolated from Biota orientalis has demonstrated anti-inflammatory effect of the compound on microglial cells by inhibiting LPS-induced (inducible nitric oxide synthase)iNOS expression and (nitric oxide)NO production, independent on MAPK and NF-kappaB, according to the study of “A pinusolide derivative, 15-methoxypinusolidic acid from Biota orientalis inhibits inducible nitric oxide synthase in microglial cells: implication for a potential anti-inflammatory effect” byChoi Y, Moon A, Kim YC.(3).
4. Neuronal damage
Water extract, pinusolidic acid of Biota orientalis has shown a potent inhibitory effect on platelet activating factor (PAF) binding to rabbit platelets using [ (3)H]PAF, rsutling in lessening the risk of neuronal damage, according to the study of “Pinusolidic acid: a platelet-activating factor inhibitor from Biota orientalis” by Yang HO, Han BH.(4).
5. Coagulation
Quercitrin of Bo Ye has exerted the activity of promotes hemostasis or stop bleeding, according to the study of “Studies on the antihemostatic substances in herbs classified as hemostatics in traditional Chinese medicine. I. On the antihemostatic principles in Sophora japonica L” byH Ishida, T Umino, K Tsuji, T Kosuge(5).
6. Gout and hyperuricemia
Biota orientalis (BO) extract and its flavonoid constituents quercetin and rutin has exerted inhibitory actions on the xanthine dehydrogenase/xanthine oxidase (XDH/XO) activities, according to the study of “Effects of Biota orientalis extract and its flavonoid constituents, quercetin and rutin on serum uric acid levels in oxonate-induced mice and xanthine dehydrogenase and xanthine oxidase activities in mouse liver” by Ji Xiao Zhu, Ying Wang, Ling Dong Kong , Cheng Yang, Xin Zhang(6).
7. Etc.
Side effects
1. Long term intake and overdoses can cause dizziness, nausea, vomiting. etc.
2. Do not use the herb, if you are pregnant or breast feeding with no permission of related field specialist.
3. Etc.
Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Sources
(1) http://www.springerlink.com/content/g056714255k70077/
(2) http://www.ncbi.nlm.nih.gov/pubmed/21854102
(3) http://www.ncbi.nlm.nih.gov/pubmed/18328446
(4) http://www.ncbi.nlm.nih.gov/pubmed/17253221
(5) http://sc.chat-shuffle.net/paper/uid:110003627815
(6) http://www.sciencedirect.com/science/article/pii/S037887410400162X
The Obesity' Research and Studies of Spanish Ketogenic Mediterranean Diet
Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Obesity is a medical condition of excess body fat accumulated overtime, while overweight is a condition of excess body weight relatively to the height. According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered over weight, while a BMI of over 30 is an indication of obesity. According to the statistic, 68% of American population are either overweight or obese.
You can calculate your BMI index BMI= weight (kg)/ height (m2)
The Spanish Ketogenic Mediterranean Diet
In the study 31 obese subjects (22 male and 19 female) with the inclusion criteria whose body mass index and age was 36.46 +/- 2.22 and 38.48 +/- 2.27, respectively. This Ketogenic diet was called "Spanish Ketogenic Mediterranean Diet" (SKMD) due to the incorporation of virgin olive oil as the principal source of fat (> or =30 ml/day), moderate red wine intake (200-400 ml/day), green vegetables and salads as the main source of carbohydrates and fish as the main source of proteins, conducted by University of Córdoba(1), found that The Spanish Ketogenic Mediterranean Diet(SKMD) is safe, an effective way of losing weight, promoting non-atherogenic lipid profiles, lowering blood pressure and improving fasting blood glucose levels. Future research should include a larger sample size, a longer term use and a comparison with other ketogenic diets.
Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
(1) "Spanish Ketogenic Mediterranean Diet: a healthy cardiovascular diet for weight loss by Pérez-Guisado J, Muñoz-Serrano A, Alonso-Moraga A.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Obesity is a medical condition of excess body fat accumulated overtime, while overweight is a condition of excess body weight relatively to the height. According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered over weight, while a BMI of over 30 is an indication of obesity. According to the statistic, 68% of American population are either overweight or obese.
You can calculate your BMI index BMI= weight (kg)/ height (m2)
The Spanish Ketogenic Mediterranean Diet
In the study 31 obese subjects (22 male and 19 female) with the inclusion criteria whose body mass index and age was 36.46 +/- 2.22 and 38.48 +/- 2.27, respectively. This Ketogenic diet was called "Spanish Ketogenic Mediterranean Diet" (SKMD) due to the incorporation of virgin olive oil as the principal source of fat (> or =30 ml/day), moderate red wine intake (200-400 ml/day), green vegetables and salads as the main source of carbohydrates and fish as the main source of proteins, conducted by University of Córdoba(1), found that The Spanish Ketogenic Mediterranean Diet(SKMD) is safe, an effective way of losing weight, promoting non-atherogenic lipid profiles, lowering blood pressure and improving fasting blood glucose levels. Future research should include a larger sample size, a longer term use and a comparison with other ketogenic diets.
Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
(1) "Spanish Ketogenic Mediterranean Diet: a healthy cardiovascular diet for weight loss by Pérez-Guisado J, Muñoz-Serrano A, Alonso-Moraga A.
Phytochemicals in Foods - The Effects of Stigmasterol
Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Stigmasterol
Stigmasterol is a phytochemincal in the class of Phytosterols, belonging to the group of Lipids, found abundantly in , legumes, nuts, seeds, unpasteurized milk, buckwheat. etc.
Health Benefits
1. Anti-osteoarthritic effects
In the investigation of the effects of stigmasterol, a plant sterol, on the inflammatory mediators and metalloproteinases produced by chondrocytes, found that stigmasterol inhibits several pro-inflammatory and matrix degradation mediators typically involved in OA-induced cartilage degradation, at least in part through the inhibition of the NF-kappaB pathway. These promising results justify further ex vivo and in vivo investigations with stigmasterol, according to "Stigmasterol: a phytosterol with potential anti-osteoarthritic properties" by Gabay O, Sanchez C, Salvat C, Chevy F, Breton M, Nourissat G, Wolf C, Jacques C, Berenbaum F.(1)
2. Cytotoxic and apoptotic effects
In the evaluation of the cytotoxic effects of the oxidized derivatives of β-sitosterol and determined that phytosterol oxidation products (POP) have a similar but less potent toxicity compared to their cholesterol equivalents, found that the antioxidants α-tocopherol, γ-tocopherol, and β-carotene did not protect against apoptosis induced by 7β-OH and diepoxide stigmasterol; however, α-tocopherol was found to protect against epoxydiol-induced apoptosis. The cellular antioxidant, glutathione, was depleted and the apoptotic protein, Bcl-2, was down-regulated by the stigmasterol oxides identified as apoptotic, according to "Cytotoxic and apoptotic effects of the oxidized derivatives of stigmasterol in the U937 human monocytic cell line" by O'Callaghan YC, Foley DA, O'Connell NM, McCarthy FO, Maguire AR, O'Brien NM.(2)
3. Antimicrobial and antioxidant activities
In the investigation of Phytochemical, antimicrobial and 2,2-diphenyl-1-picryl-hydrazyl-hydrate (DPPH)-radical scavenging investigations of the hexane and EtOAc extracts of the stem bark of M. barteri for the first time, found that seven compounds, including two guanidine alkaloids: millaurine (2) and milletonine (7); one flavonoid: afzelin (6); four sterols: β-sitosterol (1), β-sitosterol glucoside (3), mixture of stigmasterol (4) and β-sitosterol (5) palmitates isolated from stem bark of hexane and ethyl acetate extracts of M. barteri. These extracts showed antimicrobial activity on the set of germs tested with minimum inhibitory concentration values varying from 64 to 512 µg/mL, as well as antioxidant activity (IC50 62.74 and 77.23 µg/mL), according to "Chemical constituents of Millettia barteri and their antimicrobial and antioxidant activities" by Havyarimana L, Ndendoung ST, Tamokou Jde D, Atchadé Ade T, Tanyi JM.(3)
4. Ameliorating effects
In the study of effects of stigmasterol on scopolamine-induced memory impairments using the passive avoidance and the Morris water maze tasks in mice, found that stigmasterol-induced cognitive ameliorative effects are mediated by the enhancement of cholinergic neurotransmission system via the activation of estrogen or NMDA receptors, according to "The ameliorating effects ofstigmasterol on scopolamine-induced memory impairments in mice" by Park SJ, Kim DH, Jung JM, Kim JM, Cai M, Liu X, Hong JG, Lee CH, Lee KR, Ryu JH.(4)
5. Anti-snake venom activities
In the investigation of the anti-snake venom properties of callus of crude extracts of S. saponaria, found that Sapindus saponaria extracts (B and C) and fractions (A1 and A2) showed β-sitosterol and stigmasterol as their main compounds of presented anti-ophidian activity and could be used as an adjuvant to serum therapy or for its supplementation, and in addition, as a rich source of potential inhibitors of enzymes involved in several pathophysiological human and animal diseases, according to "Anti-snake venom activities of extracts and fractions from callus cultures of Sapindus saponaria" by da Silva ML, Marcussi S, Fernandes RS, Pereira PS, Januário AH, França SC, Da Silva SL, Soares AM, Lourenço MV.(5)
6. Birth control
In the investigation of stigmasterol derivative and the effects of petroleum ether extract of C. coromandelina (PECC) aerial parts on the onset of reproductive maturity and the ovarian steroidogenesis in immature female mice, found that the isolated compound was characterized as stigmasterol derivative. PECC treatment caused a remarkable delay (30.27 and 18.56%, respectively, by low dose) in sexual maturity compared to vehicle control as evidenced by the age of vaginal opening and appearance of first estrus (cornified smear). PECC treatment also caused a significant fall (58.6 and 50.0%, respectively, by low dose) in Δ(5)-3β-HSD and G 6-PDH activities involved in ovarian steroidogenesis compared to vehicle control. Total cholesterol and ascorbic acid content in ovaries and carbonic anhydrase activity in uterus were increased significantly (low dose by 49.3, 424.6 and 82.4%, respectively) along with a reduction in the weight of ovary, uterus and pituitary in comparison to that of control, according to "Fractionation ofstigmasterol derivative and study of the effects of Celsia coromandelina aerial parts petroleum ether extract on appearance of puberty and ovarian steroidogenesis in immature mice" by Pal D, Mazumder UK, Gupta M.(6)
7. Antihyperlipidemic activity
In the determination of the Antihyperlipidemic activity of the methanol extract obtained from the fruits of the plant L. siceraria showed a positive Liebermann-Burchard test for sterols including fucosterol (1), racemosol (2), stigmasterol (3), and stigmasta-7,22-dien-3β,4β-diol (4), significant reductions in lipid profiles which included cholesterol, triglycerides, LDL and VLDL. In addition, a significant increase in HDL cholesterol observed, which is a good cholesterol that protects hearts from coronary artery diseases, according to "Isolation of phytosterols and antihyperlipidemic activity of Lagenaria siceraria" by Kalsait RP, Khedekar PB, Saoji AN, Bhusari KP.(7)
8. Anti inflammatory effect
In the determination of three new labdane-type diterpenes 1-3, named coronarins G-I as well as seven known 4-10, coronarin D, coronarin D methyl ether, hedyforrestin C, (E)-nerolidol, β-sitosterol, daucosterol, and stigmasterol isolated from rhizomes of Hedychium coronarium used for the treatment of inflammation, skin diseases, headache, and sharp pain due to rheumatism in traditional medicine, showed inhibitory effects on lipopolysaccharide-stimulated production of pro-inflammatory cytokines in bone marrow-derived dendritic cells. Among of them, compounds 1, 2, and 6 were significant inhibitors of LPS-stimulated TNF-α, IL-6, and IL-12 p40 productions with IC(50) ranging from 0.19±0.11 to 10.38±2.34 μM, according to "Chemical constituents of the rhizomes of Hedychium coronarium and their inhibitory effect on the pro-inflammatory cytokines production LPS-stimulated in bone marrow-derived dendritic cells" by Kiem PV, Thuy NT, Anh Hle T, Nhiem NX, Minh CV, Yen PH, Ban NK, Hang DT, Tai BH, Tuyen NV, Mathema VB, Koh YS, Kim YH.(8)
9. Antioxidant and antigenotoxic properties
In the assessment of the antioxidant and antigenotoxic properties of Dichloromethane and methanol extracts isolated from from Marrubium deserti de Noé. Six of them were known compounds (a mixture of the isomers cyllenin A and 15-epi-cyllenin A, marrubiin, marrulactone, marrulibacetal and β-stigmasterol) and seven known phenolic compounds were also isolated: apigenin and several 7-O-substituted derivatives (apigenin-7-O-β-neohesperidoside, apigenin-7-O-glucoside, terniflorin and apigenin-7-O-glucuronide) together with two phenylethanoid glucosides (acteoside and forsythoside B) found that some of the isolated compounds like phenylethanoid derivatives showed stronger antioxidant capacity than trolox and were also able to significantly inhibit β-galactosidase induction caused by the mutagen agent nitrofurantoin, according to "Antioxidant and antigenotoxic properties of compounds isolated from Marrubium deserti de Noé" by Zaabat N, Hay AE, Michalet S, Darbour N, Bayet C, Skandrani I, Chekir-Ghedira L, Akkal S, Dijoux-Franca MG.(9)
10. Antibacterial effect
In the evaluation of the dichloromethane extract from Aristolochia brevipes (Rhizoma) and the compounds isolated from this extract against several mycobacterial strains, sensitive, resistant (monoresistant), and clinical isolates (multidrug-resistant), using the alamarBlue™ microassay,
the extract fractionated by column chromatography, yielding the following eight major compounds: (1) 6α-7-dehydro-N-formylnornantenine; (2) E/Z-N-formylnornantenine; (3) 7,9-dimethoxytariacuripyrone; (4) 9-methoxy-tariacuripyrone; (5) aristololactam I; (6) β-sitosterol; (7) stigmasterol; and (8) 3-hydroxy-α-terpineol showed that The most active compound against all mycobacterial strains tested was the compound aristolactam I (5), with MIC values ranging between 12.5 and 25 µg/mL. To our knowledge, this the first report of antimycobacterial activity in this plant, according to "Antibacterial activity of Aristolochia brevipes against multidrug-resistant Mycobacterium tuberculosis" by Navarro-García VM, Luna-Herrera J, Rojas-Bribiesca MG, Álvarez-Fitz P, Ríos MY.(10)
11. Etc.
Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/19786147
(2) http://www.ncbi.nlm.nih.gov/pubmed/20828195
(3) http://www.ncbi.nlm.nih.gov/pubmed/22338120
(4) http://www.ncbi.nlm.nih.gov/pubmed/22173129
(5) http://www.ncbi.nlm.nih.gov/pubmed/22133075
(6) http://www.ncbi.nlm.nih.gov/pubmed/22092072
(7) http://www.ncbi.nlm.nih.gov/pubmed/22076759
(8) http://www.ncbi.nlm.nih.gov/pubmed/22071304
(9) http://www.ncbi.nlm.nih.gov/pubmed/21924316
(10) http://www.ncbi.nlm.nih.gov/pubmed/21876482
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Stigmasterol
Stigmasterol is a phytochemincal in the class of Phytosterols, belonging to the group of Lipids, found abundantly in , legumes, nuts, seeds, unpasteurized milk, buckwheat. etc.
Health Benefits
1. Anti-osteoarthritic effects
In the investigation of the effects of stigmasterol, a plant sterol, on the inflammatory mediators and metalloproteinases produced by chondrocytes, found that stigmasterol inhibits several pro-inflammatory and matrix degradation mediators typically involved in OA-induced cartilage degradation, at least in part through the inhibition of the NF-kappaB pathway. These promising results justify further ex vivo and in vivo investigations with stigmasterol, according to "Stigmasterol: a phytosterol with potential anti-osteoarthritic properties" by Gabay O, Sanchez C, Salvat C, Chevy F, Breton M, Nourissat G, Wolf C, Jacques C, Berenbaum F.(1)
2. Cytotoxic and apoptotic effects
In the evaluation of the cytotoxic effects of the oxidized derivatives of β-sitosterol and determined that phytosterol oxidation products (POP) have a similar but less potent toxicity compared to their cholesterol equivalents, found that the antioxidants α-tocopherol, γ-tocopherol, and β-carotene did not protect against apoptosis induced by 7β-OH and diepoxide stigmasterol; however, α-tocopherol was found to protect against epoxydiol-induced apoptosis. The cellular antioxidant, glutathione, was depleted and the apoptotic protein, Bcl-2, was down-regulated by the stigmasterol oxides identified as apoptotic, according to "Cytotoxic and apoptotic effects of the oxidized derivatives of stigmasterol in the U937 human monocytic cell line" by O'Callaghan YC, Foley DA, O'Connell NM, McCarthy FO, Maguire AR, O'Brien NM.(2)
3. Antimicrobial and antioxidant activities
In the investigation of Phytochemical, antimicrobial and 2,2-diphenyl-1-picryl-hydrazyl-hydrate (DPPH)-radical scavenging investigations of the hexane and EtOAc extracts of the stem bark of M. barteri for the first time, found that seven compounds, including two guanidine alkaloids: millaurine (2) and milletonine (7); one flavonoid: afzelin (6); four sterols: β-sitosterol (1), β-sitosterol glucoside (3), mixture of stigmasterol (4) and β-sitosterol (5) palmitates isolated from stem bark of hexane and ethyl acetate extracts of M. barteri. These extracts showed antimicrobial activity on the set of germs tested with minimum inhibitory concentration values varying from 64 to 512 µg/mL, as well as antioxidant activity (IC50 62.74 and 77.23 µg/mL), according to "Chemical constituents of Millettia barteri and their antimicrobial and antioxidant activities" by Havyarimana L, Ndendoung ST, Tamokou Jde D, Atchadé Ade T, Tanyi JM.(3)
4. Ameliorating effects
In the study of effects of stigmasterol on scopolamine-induced memory impairments using the passive avoidance and the Morris water maze tasks in mice, found that stigmasterol-induced cognitive ameliorative effects are mediated by the enhancement of cholinergic neurotransmission system via the activation of estrogen or NMDA receptors, according to "The ameliorating effects ofstigmasterol on scopolamine-induced memory impairments in mice" by Park SJ, Kim DH, Jung JM, Kim JM, Cai M, Liu X, Hong JG, Lee CH, Lee KR, Ryu JH.(4)
5. Anti-snake venom activities
In the investigation of the anti-snake venom properties of callus of crude extracts of S. saponaria, found that Sapindus saponaria extracts (B and C) and fractions (A1 and A2) showed β-sitosterol and stigmasterol as their main compounds of presented anti-ophidian activity and could be used as an adjuvant to serum therapy or for its supplementation, and in addition, as a rich source of potential inhibitors of enzymes involved in several pathophysiological human and animal diseases, according to "Anti-snake venom activities of extracts and fractions from callus cultures of Sapindus saponaria" by da Silva ML, Marcussi S, Fernandes RS, Pereira PS, Januário AH, França SC, Da Silva SL, Soares AM, Lourenço MV.(5)
6. Birth control
In the investigation of stigmasterol derivative and the effects of petroleum ether extract of C. coromandelina (PECC) aerial parts on the onset of reproductive maturity and the ovarian steroidogenesis in immature female mice, found that the isolated compound was characterized as stigmasterol derivative. PECC treatment caused a remarkable delay (30.27 and 18.56%, respectively, by low dose) in sexual maturity compared to vehicle control as evidenced by the age of vaginal opening and appearance of first estrus (cornified smear). PECC treatment also caused a significant fall (58.6 and 50.0%, respectively, by low dose) in Δ(5)-3β-HSD and G 6-PDH activities involved in ovarian steroidogenesis compared to vehicle control. Total cholesterol and ascorbic acid content in ovaries and carbonic anhydrase activity in uterus were increased significantly (low dose by 49.3, 424.6 and 82.4%, respectively) along with a reduction in the weight of ovary, uterus and pituitary in comparison to that of control, according to "Fractionation ofstigmasterol derivative and study of the effects of Celsia coromandelina aerial parts petroleum ether extract on appearance of puberty and ovarian steroidogenesis in immature mice" by Pal D, Mazumder UK, Gupta M.(6)
7. Antihyperlipidemic activity
In the determination of the Antihyperlipidemic activity of the methanol extract obtained from the fruits of the plant L. siceraria showed a positive Liebermann-Burchard test for sterols including fucosterol (1), racemosol (2), stigmasterol (3), and stigmasta-7,22-dien-3β,4β-diol (4), significant reductions in lipid profiles which included cholesterol, triglycerides, LDL and VLDL. In addition, a significant increase in HDL cholesterol observed, which is a good cholesterol that protects hearts from coronary artery diseases, according to "Isolation of phytosterols and antihyperlipidemic activity of Lagenaria siceraria" by Kalsait RP, Khedekar PB, Saoji AN, Bhusari KP.(7)
8. Anti inflammatory effect
In the determination of three new labdane-type diterpenes 1-3, named coronarins G-I as well as seven known 4-10, coronarin D, coronarin D methyl ether, hedyforrestin C, (E)-nerolidol, β-sitosterol, daucosterol, and stigmasterol isolated from rhizomes of Hedychium coronarium used for the treatment of inflammation, skin diseases, headache, and sharp pain due to rheumatism in traditional medicine, showed inhibitory effects on lipopolysaccharide-stimulated production of pro-inflammatory cytokines in bone marrow-derived dendritic cells. Among of them, compounds 1, 2, and 6 were significant inhibitors of LPS-stimulated TNF-α, IL-6, and IL-12 p40 productions with IC(50) ranging from 0.19±0.11 to 10.38±2.34 μM, according to "Chemical constituents of the rhizomes of Hedychium coronarium and their inhibitory effect on the pro-inflammatory cytokines production LPS-stimulated in bone marrow-derived dendritic cells" by Kiem PV, Thuy NT, Anh Hle T, Nhiem NX, Minh CV, Yen PH, Ban NK, Hang DT, Tai BH, Tuyen NV, Mathema VB, Koh YS, Kim YH.(8)
9. Antioxidant and antigenotoxic properties
In the assessment of the antioxidant and antigenotoxic properties of Dichloromethane and methanol extracts isolated from from Marrubium deserti de Noé. Six of them were known compounds (a mixture of the isomers cyllenin A and 15-epi-cyllenin A, marrubiin, marrulactone, marrulibacetal and β-stigmasterol) and seven known phenolic compounds were also isolated: apigenin and several 7-O-substituted derivatives (apigenin-7-O-β-neohesperidoside, apigenin-7-O-glucoside, terniflorin and apigenin-7-O-glucuronide) together with two phenylethanoid glucosides (acteoside and forsythoside B) found that some of the isolated compounds like phenylethanoid derivatives showed stronger antioxidant capacity than trolox and were also able to significantly inhibit β-galactosidase induction caused by the mutagen agent nitrofurantoin, according to "Antioxidant and antigenotoxic properties of compounds isolated from Marrubium deserti de Noé" by Zaabat N, Hay AE, Michalet S, Darbour N, Bayet C, Skandrani I, Chekir-Ghedira L, Akkal S, Dijoux-Franca MG.(9)
10. Antibacterial effect
In the evaluation of the dichloromethane extract from Aristolochia brevipes (Rhizoma) and the compounds isolated from this extract against several mycobacterial strains, sensitive, resistant (monoresistant), and clinical isolates (multidrug-resistant), using the alamarBlue™ microassay,
the extract fractionated by column chromatography, yielding the following eight major compounds: (1) 6α-7-dehydro-N-formylnornantenine; (2) E/Z-N-formylnornantenine; (3) 7,9-dimethoxytariacuripyrone; (4) 9-methoxy-tariacuripyrone; (5) aristololactam I; (6) β-sitosterol; (7) stigmasterol; and (8) 3-hydroxy-α-terpineol showed that The most active compound against all mycobacterial strains tested was the compound aristolactam I (5), with MIC values ranging between 12.5 and 25 µg/mL. To our knowledge, this the first report of antimycobacterial activity in this plant, according to "Antibacterial activity of Aristolochia brevipes against multidrug-resistant Mycobacterium tuberculosis" by Navarro-García VM, Luna-Herrera J, Rojas-Bribiesca MG, Álvarez-Fitz P, Ríos MY.(10)
11. Etc.
Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/19786147
(2) http://www.ncbi.nlm.nih.gov/pubmed/20828195
(3) http://www.ncbi.nlm.nih.gov/pubmed/22338120
(4) http://www.ncbi.nlm.nih.gov/pubmed/22173129
(5) http://www.ncbi.nlm.nih.gov/pubmed/22133075
(6) http://www.ncbi.nlm.nih.gov/pubmed/22092072
(7) http://www.ncbi.nlm.nih.gov/pubmed/22076759
(8) http://www.ncbi.nlm.nih.gov/pubmed/22071304
(9) http://www.ncbi.nlm.nih.gov/pubmed/21924316
(10) http://www.ncbi.nlm.nih.gov/pubmed/21876482
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