Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
The healthy and Weight Loss Recipe attributed to Company's Coming Salads by Jean Parè
Seem an unlikely combination but it is delicious
Large purple onion, sliced 1
Cold water to cover
Large orange, peeled and sliced 2
Cooking oil 1/4 cup (50ml)
Lemon juice 1tbsp. (15ml)
Salt 1/4 tsp. ( 1ml)
Oregano 1/4 tsp. (.05ml)
Lettuce leaves 4 -8
Ripe black olives, sliced (optional) 4
Slice onion thickly. Soaks in cold water 1/2 hour. Drain. peel organs. Sliced crosswise into thin slices. Try for 8 onion slices and 12 orange slices.
Mix cooking oil, lemon juice, salad and oregano. Add onion and orange slices. Marinate 15 minutes.
Put lettuce leaves onto 4 salad plates. Arrange 3 orange and 3 onion slices on top of each. Spoon a bit of marinate over top. Scatter olives over all. Serve 4.
Artichoke salad. Add 14 oz. (398ml) can of drained artichoke. hearts. Toss.
Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Monday, June 20, 2016
The Obesity' Research and Studies of Spanish Ketogenic Mediterranean Diet on nonalcoholic
Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Obesity is a medical condition of excess body fat accumulated overtime, while overweight is a condition of excess body weight relatively to the height. According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered over weight, while a BMI of over 30 is an indication of obesity. According to the statistic, 68% of American population are either overweight or obese.
You can calculate your BMI index BMI= weight (kg)/ height (m2)
Spanish Ketogenic Mediterranean Diet on nonalcoholic
Non-alcoholic fatty liver disease (NAFLD) is a fatty liver, as a result of fat deposit into the liver, not caused by excessive alcohol use.
In the investigation of the effect of Spanish Ketogenic Mediterranean Diet on nonalcoholic of 14 obese men meeting the inclusion criteria and whose body mass index (BMI) and age were 36.58±0.54 kg/m² and 41.18±2.28 years, respectively, found that After the diet all the subjects were free of MS according to the IDF definition, and 100% of them had normal triacylglycerols and HDLc levels, in spite of the fact that 100% of them still had a BMI of >30 kg/m². We conclude that the SKMD could be an effective and safe way to treat patients suffering from MS and the associated NAFLD(1)
Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
(1) "The effect of the Spanish Ketogenic Mediterranean Diet on nonalcoholic fatty liver disease: a pilot study" by.Pérez-Guisado J, Muñoz-Serrano A.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Obesity is a medical condition of excess body fat accumulated overtime, while overweight is a condition of excess body weight relatively to the height. According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered over weight, while a BMI of over 30 is an indication of obesity. According to the statistic, 68% of American population are either overweight or obese.
You can calculate your BMI index BMI= weight (kg)/ height (m2)
Spanish Ketogenic Mediterranean Diet on nonalcoholic
Non-alcoholic fatty liver disease (NAFLD) is a fatty liver, as a result of fat deposit into the liver, not caused by excessive alcohol use.
In the investigation of the effect of Spanish Ketogenic Mediterranean Diet on nonalcoholic of 14 obese men meeting the inclusion criteria and whose body mass index (BMI) and age were 36.58±0.54 kg/m² and 41.18±2.28 years, respectively, found that After the diet all the subjects were free of MS according to the IDF definition, and 100% of them had normal triacylglycerols and HDLc levels, in spite of the fact that 100% of them still had a BMI of >30 kg/m². We conclude that the SKMD could be an effective and safe way to treat patients suffering from MS and the associated NAFLD(1)
Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
(1) "The effect of the Spanish Ketogenic Mediterranean Diet on nonalcoholic fatty liver disease: a pilot study" by.Pérez-Guisado J, Muñoz-Serrano A.
Sunday, June 19, 2016
Phytochemicals in Foods - The Effects of Silymarin
Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Silymarin
Silymarin is a phytochemical in the class of phenolic acids, found abundantly in peppermint, licorice, peanut, wheat, etc.
Health Benefits
1. Anti toxic effects
In the investigation of the effect of silymarin on doxorubicin-induced toxicity to the rat kidney, heart, and liver, found that the silymarin group received silymarin(100mg/kg) every other day. In the doxorubicin + silymarin group, silymarin was injected ip at 100 mg/kg dose for 5 days before doxorubicin administration (10 mg/kg, single ip injection) and then continued daily thereafter until euthanization, Doxorubicin caused a significant increase in serum NO levels compared to controls. Silymarin pretreatment group lowered these. Histopathological and electron microscopic examinations of kidney, heart, and liver sections showed doxorubicin to cause myocardial and renal injury which was levv evident insilymarin treated rats, according to "Protective Effects of Silymarin against Doxorubicin-induced Toxicity"by Cecen E, Dost T, Culhaci N, Karul A, Ergur B, Birincioglu M.(1)
2. Hepaprotective effects
In the investigation of the role of curcumin (CUR), silymarin (SILY) and N-acetylcysteine (N-ACET) on hepatotoxicity by ATT drugs using an in vitro model of human hepatocellular carcinoma cell line (HepG2), found that that the presence of hepatoprotective drugs during treatment of HepG2 cells with ATT drugs lowers the hepatotoxic effect of the latter, according to "Protective effect of curcumin,silymarin and N-acetylcysteine on antitubercular drug-induced hepatotoxicity assessed in an in vitro model' by Singh M, Sasi P, Gupta VH, Rai G, Amarapurkar DN, Wangikar PP.(2)
3. Anti Cervical cancer
In the evaluation of the potential action of silymarin against cervical cancer and its mechanism of action, found that Silymarin induced apoptosis through the modulation of Bcl-2 family proteins and activation of caspase 3. Silymarin also inhibited the phosphorylation of Akt with an increase in expression of phosphatase and tensin homolog (PTEN). We also observed that silymarin suppressed C-33A cell invasion and wound-healing migration in a concentration-dependent manner. Western-blot analysis showed that silymarin significantly inhibited the expression of matrix metalloproteinase-9 (MMP-9) in C-33A cells, according to "SilymarinInhibits Cervical Cancer Cell Through an Increase of Phosphatase and Tensin Homolog" by Yu HC, Chen LJ, Cheng KC, Li YX, Yeh CH, Cheng JT.(3)
4. Anti cancers
In the review of the summarization of the recent investigations and mechanistic studies regarding possible molecular targets of silymarin for cancer prevention, found that the protective effects of silymarin and its major active constituent, silibinin, studied in various tissues, suggest a clinical application in cancerpatients as an adjunct to established therapies, to prevent or reduce chemotherapy as well as radiotherapy-induced toxicity. This review focuses on the chemistry and analogues of silymarin, multiple possible molecular mechanisms, in vitro as well as in vivo anti-cancer activities, and studies on human clinical trials, according to "Multitargeted therapy of cancer by silymarin" by Ramasamy K, Agarwal R.(4)
5. Prostate cancer
In the investigation of the stidy of three rat PCA cell lines, namely H-7, I-8, and I-26, were treated with silibinin or silymarin, a crude silibinin-containing preparation, at various doses for varying lengths of time. Cell growth and viability studies were carried out by using hemocytometer and Trypan blue dye exclusion methods, found that silibinin as well as silymarin induce growth inhibition and apoptosis in rat PCA cells. These results form a strong rationale for PCA prevention and therapeutic intervention studies with silibinin and silymarin in animal models, such as the MNU-testosterone rat PCA model, to establish their efficacy and to further define their mechanisms of action under in vivo conditions, according to "Antiproliferative and apoptotic effects of silibinin in rat prostate cancercells" by Tyagi A, Bhatia N, Condon MS, Bosland MC, Agarwal C, Agarwal R.(5)
6. Liver cancer
In the assessment of the mechanisms involved in the growth inhibitory effect ofsilymarin, in humanhepatocellular carcinoma, found that Silymarin inhibited population growth of the hepatocellular carcinoma cells in a dose-dependent manner, and the percentage of apoptotic cells was increased after treatment with 50 and 75 microg/ml silymarin for 24 h. Silymarin treatment increased the proportion of cells with reduced DNA content (sub-G(0)/G(1) or A(0) peak), indicative of apoptosis with loss of cells in the G(1) phase. Silymarin also decreased mitochondrial transmembrane potential of the cells, thereby increasing levels of cytosolic cytochrome c while up-regulating expression of pro-apoptotic proteins (such as p53, Bax, APAF-1 and caspase-3) with concomitant decrease in anti-apoptotic proteins (Bcl-2 and survivin) and proliferation-associated proteins (beta-catenin, cyclin D1, c-Myc and PCNA), according to "Silymarin inhibited proliferation and induced apoptosis in hepatic cancer cells" by Ramakrishnan G, Lo Muzio L, Elinos-Báez CM, Jagan S, Augustine TA, Kamaraj S, Anandakumar P, Devaki T.(6)
7. Bladder cancer
In the searching the underlying mechanisms and examining the intravesical efficacy of silibinin, a natural flavonoid in the prevention and treatment of bladdercancer. Human bladder carcinoma cell line 5637, which has the same molecular features of high-risk superficial bladder cancer, was used as the model system in vitro and in vivo, found that oral silibinin suppressed the growth of 5637 xenografts, which was accompanied with the activation of caspase-3, downregulation of survivin, and increased translocation of AIF. Furthermore, intravesical silibinin effectively inhibited the carcinogenesis and progression of bladder cancer in rats initiated by MNU by reducing the incidence of superficial and invasive bladder lesions without any side effects, which was accompanied with proapoptotic effects, according to "Chemopreventive and chemotherapeutic effects of intravesical silibinin against bladder cancer by acting on mitochondria" by Zeng J, Sun Y, Wu K, Li L, Zhang G, Yang Z, Wang Z, Zhang D, Xue Y, Chen Y, Zhu G, Wang X, He D.(7)
8. Antioxidants and anti cancers
In the study of the effect of three natural antioxidants curcumin, silymarin and acteoside on AP9-cd (standardized lignan composition from Cedrus deodara) induced cytotoxicity in human leukemia HL-60 cells, found that out of the three antioxidants, curcumin was found to be more potent than acteoside and silymarinin terms of enhancing the apoptotic potential of AP9-cd. These results propose an important role of natural antioxidant as adjuvant to enhance the anticancer potential of AP9-cd and more likely other anti-neoplastic therapeutics, according to "Natural antioxidants synergistically enhance the anticancer potential of AP9-cd, a novel lignan composition from Cedrus deodara in human leukemia HL-60 cells" by Saxena A, Saxena AK, Singh J, Bhushan S.(8)
9. Antimetastatic effects
In the investigation of Silibinin, a popular dietary supplement isolated from milk thistle seed extracts against a variety of cancers, found that detailed mechanistic analyses revealed that silibinin targets signaling molecules involved in the regulation of epithelial-to-mesenchymal transition, proteases activation, adhesion, motility, invasiveness as well as the supportive tumor-microenvironment components, thereby inhibiting metastasis. Overall, the long history of human use, remarkable nontoxicity, and preclinical efficacy strongly favor the clinical use of silibinin against advanced metastatic cancers, according to "Antimetastatic efficacy of silibinin: molecular mechanisms and therapeutic potential againstcancer" by Deep G, Agarwal R.(9)
10. Gastric cancer
In the determination of the effect of silibinin on TNF-alpha-induced MMP-9 expression in gastric cancer cell lines. MMP-9 mRNA and protein expression was dose-dependently increased by TNF-alpha in SNU216 and SNU668 gastric cancercells, found that the expression of MMP-9 was significantly increased by CA-MEK overexpression, but not by CA-Akt overexpression. Taken together, we suggest that silibinin down-regulates TNF-alpha- induced MMP-9 expression through inhibition of the MEK/ERK pathway in gastric cancer cells, according to "Silibinin suppresses TNF-alpha-induced MMP-9 expression in gastric cancer cells through inhibition of the MAPK pathway" by Kim S, Choi MG, Lee HS, Lee SK, Kim SH, Kim WW, Hur SM, Kim JH, Choe JH, Nam SJ, Yang JH, Kim S, Lee JE, Kim JS.(10)
11. Etc.
Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/22320977
(2) http://www.ncbi.nlm.nih.gov/pubmed/22318308
(3) http://www.ncbi.nlm.nih.gov/pubmed/22016029
(4) http://www.ncbi.nlm.nih.gov/pubmed/18472213
(5) http://www.ncbi.nlm.nih.gov/pubmed/12386921
(6) http://www.ncbi.nlm.nih.gov/pubmed/19317806
(7) http://www.ncbi.nlm.nih.gov/pubmed/21220495
(8) http://www.ncbi.nlm.nih.gov/pubmed/20932957
(9) http://www.ncbi.nlm.nih.gov/pubmed/20714788
(10) http://www.ncbi.nlm.nih.gov/pubmed/19924065
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Silymarin
Silymarin is a phytochemical in the class of phenolic acids, found abundantly in peppermint, licorice, peanut, wheat, etc.
Health Benefits
1. Anti toxic effects
In the investigation of the effect of silymarin on doxorubicin-induced toxicity to the rat kidney, heart, and liver, found that the silymarin group received silymarin(100mg/kg) every other day. In the doxorubicin + silymarin group, silymarin was injected ip at 100 mg/kg dose for 5 days before doxorubicin administration (10 mg/kg, single ip injection) and then continued daily thereafter until euthanization, Doxorubicin caused a significant increase in serum NO levels compared to controls. Silymarin pretreatment group lowered these. Histopathological and electron microscopic examinations of kidney, heart, and liver sections showed doxorubicin to cause myocardial and renal injury which was levv evident insilymarin treated rats, according to "Protective Effects of Silymarin against Doxorubicin-induced Toxicity"by Cecen E, Dost T, Culhaci N, Karul A, Ergur B, Birincioglu M.(1)
2. Hepaprotective effects
In the investigation of the role of curcumin (CUR), silymarin (SILY) and N-acetylcysteine (N-ACET) on hepatotoxicity by ATT drugs using an in vitro model of human hepatocellular carcinoma cell line (HepG2), found that that the presence of hepatoprotective drugs during treatment of HepG2 cells with ATT drugs lowers the hepatotoxic effect of the latter, according to "Protective effect of curcumin,silymarin and N-acetylcysteine on antitubercular drug-induced hepatotoxicity assessed in an in vitro model' by Singh M, Sasi P, Gupta VH, Rai G, Amarapurkar DN, Wangikar PP.(2)
3. Anti Cervical cancer
In the evaluation of the potential action of silymarin against cervical cancer and its mechanism of action, found that Silymarin induced apoptosis through the modulation of Bcl-2 family proteins and activation of caspase 3. Silymarin also inhibited the phosphorylation of Akt with an increase in expression of phosphatase and tensin homolog (PTEN). We also observed that silymarin suppressed C-33A cell invasion and wound-healing migration in a concentration-dependent manner. Western-blot analysis showed that silymarin significantly inhibited the expression of matrix metalloproteinase-9 (MMP-9) in C-33A cells, according to "SilymarinInhibits Cervical Cancer Cell Through an Increase of Phosphatase and Tensin Homolog" by Yu HC, Chen LJ, Cheng KC, Li YX, Yeh CH, Cheng JT.(3)
4. Anti cancers
In the review of the summarization of the recent investigations and mechanistic studies regarding possible molecular targets of silymarin for cancer prevention, found that the protective effects of silymarin and its major active constituent, silibinin, studied in various tissues, suggest a clinical application in cancerpatients as an adjunct to established therapies, to prevent or reduce chemotherapy as well as radiotherapy-induced toxicity. This review focuses on the chemistry and analogues of silymarin, multiple possible molecular mechanisms, in vitro as well as in vivo anti-cancer activities, and studies on human clinical trials, according to "Multitargeted therapy of cancer by silymarin" by Ramasamy K, Agarwal R.(4)
5. Prostate cancer
In the investigation of the stidy of three rat PCA cell lines, namely H-7, I-8, and I-26, were treated with silibinin or silymarin, a crude silibinin-containing preparation, at various doses for varying lengths of time. Cell growth and viability studies were carried out by using hemocytometer and Trypan blue dye exclusion methods, found that silibinin as well as silymarin induce growth inhibition and apoptosis in rat PCA cells. These results form a strong rationale for PCA prevention and therapeutic intervention studies with silibinin and silymarin in animal models, such as the MNU-testosterone rat PCA model, to establish their efficacy and to further define their mechanisms of action under in vivo conditions, according to "Antiproliferative and apoptotic effects of silibinin in rat prostate cancercells" by Tyagi A, Bhatia N, Condon MS, Bosland MC, Agarwal C, Agarwal R.(5)
6. Liver cancer
In the assessment of the mechanisms involved in the growth inhibitory effect ofsilymarin, in humanhepatocellular carcinoma, found that Silymarin inhibited population growth of the hepatocellular carcinoma cells in a dose-dependent manner, and the percentage of apoptotic cells was increased after treatment with 50 and 75 microg/ml silymarin for 24 h. Silymarin treatment increased the proportion of cells with reduced DNA content (sub-G(0)/G(1) or A(0) peak), indicative of apoptosis with loss of cells in the G(1) phase. Silymarin also decreased mitochondrial transmembrane potential of the cells, thereby increasing levels of cytosolic cytochrome c while up-regulating expression of pro-apoptotic proteins (such as p53, Bax, APAF-1 and caspase-3) with concomitant decrease in anti-apoptotic proteins (Bcl-2 and survivin) and proliferation-associated proteins (beta-catenin, cyclin D1, c-Myc and PCNA), according to "Silymarin inhibited proliferation and induced apoptosis in hepatic cancer cells" by Ramakrishnan G, Lo Muzio L, Elinos-Báez CM, Jagan S, Augustine TA, Kamaraj S, Anandakumar P, Devaki T.(6)
7. Bladder cancer
In the searching the underlying mechanisms and examining the intravesical efficacy of silibinin, a natural flavonoid in the prevention and treatment of bladdercancer. Human bladder carcinoma cell line 5637, which has the same molecular features of high-risk superficial bladder cancer, was used as the model system in vitro and in vivo, found that oral silibinin suppressed the growth of 5637 xenografts, which was accompanied with the activation of caspase-3, downregulation of survivin, and increased translocation of AIF. Furthermore, intravesical silibinin effectively inhibited the carcinogenesis and progression of bladder cancer in rats initiated by MNU by reducing the incidence of superficial and invasive bladder lesions without any side effects, which was accompanied with proapoptotic effects, according to "Chemopreventive and chemotherapeutic effects of intravesical silibinin against bladder cancer by acting on mitochondria" by Zeng J, Sun Y, Wu K, Li L, Zhang G, Yang Z, Wang Z, Zhang D, Xue Y, Chen Y, Zhu G, Wang X, He D.(7)
8. Antioxidants and anti cancers
In the study of the effect of three natural antioxidants curcumin, silymarin and acteoside on AP9-cd (standardized lignan composition from Cedrus deodara) induced cytotoxicity in human leukemia HL-60 cells, found that out of the three antioxidants, curcumin was found to be more potent than acteoside and silymarinin terms of enhancing the apoptotic potential of AP9-cd. These results propose an important role of natural antioxidant as adjuvant to enhance the anticancer potential of AP9-cd and more likely other anti-neoplastic therapeutics, according to "Natural antioxidants synergistically enhance the anticancer potential of AP9-cd, a novel lignan composition from Cedrus deodara in human leukemia HL-60 cells" by Saxena A, Saxena AK, Singh J, Bhushan S.(8)
9. Antimetastatic effects
In the investigation of Silibinin, a popular dietary supplement isolated from milk thistle seed extracts against a variety of cancers, found that detailed mechanistic analyses revealed that silibinin targets signaling molecules involved in the regulation of epithelial-to-mesenchymal transition, proteases activation, adhesion, motility, invasiveness as well as the supportive tumor-microenvironment components, thereby inhibiting metastasis. Overall, the long history of human use, remarkable nontoxicity, and preclinical efficacy strongly favor the clinical use of silibinin against advanced metastatic cancers, according to "Antimetastatic efficacy of silibinin: molecular mechanisms and therapeutic potential againstcancer" by Deep G, Agarwal R.(9)
10. Gastric cancer
In the determination of the effect of silibinin on TNF-alpha-induced MMP-9 expression in gastric cancer cell lines. MMP-9 mRNA and protein expression was dose-dependently increased by TNF-alpha in SNU216 and SNU668 gastric cancercells, found that the expression of MMP-9 was significantly increased by CA-MEK overexpression, but not by CA-Akt overexpression. Taken together, we suggest that silibinin down-regulates TNF-alpha- induced MMP-9 expression through inhibition of the MEK/ERK pathway in gastric cancer cells, according to "Silibinin suppresses TNF-alpha-induced MMP-9 expression in gastric cancer cells through inhibition of the MAPK pathway" by Kim S, Choi MG, Lee HS, Lee SK, Kim SH, Kim WW, Hur SM, Kim JH, Choe JH, Nam SJ, Yang JH, Kim S, Lee JE, Kim JS.(10)
11. Etc.
Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/22320977
(2) http://www.ncbi.nlm.nih.gov/pubmed/22318308
(3) http://www.ncbi.nlm.nih.gov/pubmed/22016029
(4) http://www.ncbi.nlm.nih.gov/pubmed/18472213
(5) http://www.ncbi.nlm.nih.gov/pubmed/12386921
(6) http://www.ncbi.nlm.nih.gov/pubmed/19317806
(7) http://www.ncbi.nlm.nih.gov/pubmed/21220495
(8) http://www.ncbi.nlm.nih.gov/pubmed/20932957
(9) http://www.ncbi.nlm.nih.gov/pubmed/20714788
(10) http://www.ncbi.nlm.nih.gov/pubmed/19924065
Traditional Chinese Medicine Herbal Therapy - Popular Chinese Herbs - Che Qian Cao (Herba Plantaginis)
Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Chen Pi
Chen Pi is also known as Tangerine Peel, the bitter, acrid and warm herb has been used in Traditional Chinese medicine to improve digestion, stop vomiting, hiccups and bleeding increase blood pressure, stimulate blood vessels, regulate movement of uterus, as it regulate the movement of Qi, Middle burner, dries Dampness, transforms Phlegm, etc., by enhancing the functions of lung and spleen channels.
Ingredients
1. d-limonene
2. β-myrcene
3. α-thujene
4. α-pinene
5. β-pinene
6. β-myrcene
7. α-terpinene
8. Linalool
9. Thymol
10. Citronellal
11. Citral
12. Hesperidin
13. Neohesperidin
14. Tangeretin,5,6,7,8,4’-pentamethoxyflavone
15. Nobiletin
16. Tangeretin
17. Etc.
Health Benefits
1. Anti obesity Effects and Hepatic steatosis
in the investigation of the antiobesity activity of immature C. sunki peel extract (designated CSE) using high-fat diet (HFD)-induced obese C57BL/6 mice and mature 3T3-L1 adipocytes, found that CSE supplementation reduced serum levels of glutamic pyruvic transaminase, glutamic oxaloacetic transaminase, and lactate dehydrogenase. Moreover, it significantly decreased the accumulation of fatty droplets in liver tissue, suggesting a protective effect against HFD-induced hepatic steatosis. Dietary supplementation with CSE reversed the HFD-induced decrease in the phosphorylation levels of AMP-activated protein kinase (AMPK) and acetyl-CoA carboxylase (ACC), which are related to fatty acid β-oxidation, in the epididymal adipose tissue. Also, CSE increased AMPK and ACC phosphorylation in mature 3T3-L1 adipocytes. CSE also enhanced lipolysis by phosphorylation of cAMP-dependent protein kinase (PKA) and hormone-sensitive lipase (HSL) in mature 3T3-L1 adipocytes, according to “Immature Citrus sunki Peel Extract Exhibits Antiobesity Effects by β-Oxidation and Lipolysis in High-Fat Diet-Induced Obese Mice” by Kang SI, Shin HS, Kim HM, Hong YS, Yoon SA, Kang SW, Kim JH, Kim MH, Ko HC, Kim SJ.(1).
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Chen Pi
Chen Pi is also known as Tangerine Peel, the bitter, acrid and warm herb has been used in Traditional Chinese medicine to improve digestion, stop vomiting, hiccups and bleeding increase blood pressure, stimulate blood vessels, regulate movement of uterus, as it regulate the movement of Qi, Middle burner, dries Dampness, transforms Phlegm, etc., by enhancing the functions of lung and spleen channels.
Ingredients
1. d-limonene
2. β-myrcene
3. α-thujene
4. α-pinene
5. β-pinene
6. β-myrcene
7. α-terpinene
8. Linalool
9. Thymol
10. Citronellal
11. Citral
12. Hesperidin
13. Neohesperidin
14. Tangeretin,5,6,7,8,4’-pentamethoxyflavone
15. Nobiletin
16. Tangeretin
17. Etc.
Health Benefits
1. Anti obesity Effects and Hepatic steatosis
in the investigation of the antiobesity activity of immature C. sunki peel extract (designated CSE) using high-fat diet (HFD)-induced obese C57BL/6 mice and mature 3T3-L1 adipocytes, found that CSE supplementation reduced serum levels of glutamic pyruvic transaminase, glutamic oxaloacetic transaminase, and lactate dehydrogenase. Moreover, it significantly decreased the accumulation of fatty droplets in liver tissue, suggesting a protective effect against HFD-induced hepatic steatosis. Dietary supplementation with CSE reversed the HFD-induced decrease in the phosphorylation levels of AMP-activated protein kinase (AMPK) and acetyl-CoA carboxylase (ACC), which are related to fatty acid β-oxidation, in the epididymal adipose tissue. Also, CSE increased AMPK and ACC phosphorylation in mature 3T3-L1 adipocytes. CSE also enhanced lipolysis by phosphorylation of cAMP-dependent protein kinase (PKA) and hormone-sensitive lipase (HSL) in mature 3T3-L1 adipocytes, according to “Immature Citrus sunki Peel Extract Exhibits Antiobesity Effects by β-Oxidation and Lipolysis in High-Fat Diet-Induced Obese Mice” by Kang SI, Shin HS, Kim HM, Hong YS, Yoon SA, Kang SW, Kim JH, Kim MH, Ko HC, Kim SJ.(1).
2. Antioxidant effects
In the evaluation of the antioxidant effects of fresh juice and peel extract of Citrus aurantifolia (Christm), found that 5 μl of lime juice didn’t change LDL oxidation. 10 μl of juice inhibited LDL oxidation, and with increasing the juice concentration, LDL was oxidized faster. The higher concentrations of peel extract prevented LDL oxidation better than the lower ones, according to “Antioxidant effects of Citrus aurantifolia (Christm) juice and peel extract on LDL oxidation” by Boshtam M, Moshtaghian J, Naderi G, Asgary S, Nayeri H.(2).
3. Anti bacterial effects
In the observation if orange peel and pulp affected E. coli O157:H7 populations in vivo, found that opulations of inoculated E. coli O157:H7 were reduced by OP treatment throughout the gastrointestinal tract; however, this reduction reached significant levels in the rumen (P < 0.05) of sheep fed 10% OP diets. Cecal and rectal populations of E. coli O157:H7 were reduced (P < 0.05) by inclusion of both 5 and 10% OP diets, according to “Escherichia coli O157:H7 populations in ruminants can be reduced by orange peel product feeding” by Callaway TR, Carroll JA, Arthington JD, Edrington TS, Rossman ML, Carr MA, Krueger NA, Ricke SC, Crandall P, Nisbet DJ.(3) 4. Vascular diseases
In the examination of the effect of tangeretin on platelet-derived growth factor (PDGF)-BB-induced proliferation and migration of rat aortic smooth muscle cells (RASMCs), found that tangeretin could suppress PDGF-BB-induced proliferation and migration of RASMCs through the suppression of PI3K/AKT signaling pathway, and may be a potential candidate for preventing or treating vascular diseases, such as atherosclerosis and restenosis, according to “Tangeretin, a citrus flavonoid, inhibits PGDF-BB-induced proliferation and migration of aortic smooth muscle cells by blocking AKT activation” by Seo J, Lee HS, Ryoo S, Seo JH, Min BS, Lee JH.(4).
5. Antioxidant, anti-inflammatory, and cytotoxic activities
In the isolation of the effects of an aqueous methanolic extract of fruit peel of Citrus pyriformis Hassk. (Rutaceae) resulted in seven compounds including one coumarin (citropten), two limonoids (limonin and deacetylnomilin), and four sterols (stigmasterol, ergosterol, sitosteryl-3-beta-D-glucoside, and sitosteryl-6′-O-acyl-3-beta-D-glucoside), found that The total methanolic extract of the peel and the petroleum ether, dichloromethane, and ethyl acetate fractions were screened for their antioxidant and anti-inflammatory activities. The ethyl acetate fraction exhibited a significant scavenging activity for DPPH free radicals (IC50 = 132.3 microg/mL). The petroleum ether fraction inhibited 5-lipoxygenase with IC50 = 30.6 microg/mL indicating potential anti-inflammatory properties. Limonin has a potent cytotoxic effect against COS7 cells [IC50 = (35.0 +/- 6.1) microM] compared with acteoside as a positive control [IC50 = (144.5 +/- 10.96) microM], according to “Secondary metabolites of ponderosa lemon (Citrus pyriformis) and their antioxidant, anti-inflammatory, and cytotoxic activities” by Hamdan D, El-Readi MZ, Tahrani A, Herrmann F, Kaufmann D, Farrag N, El-Shazly A, Wink M.(5).
6. Chronic allergic dermatitis
In the examination of whether extract from immature natsumikan peel prevents development of chronic allergic dermatitis in mice, found that treatment of natsumikan significantly attenuated the increase in ear swelling and improved dermatitis scores. In addition, increases in serum d-ROM were attenuated by a treatment of natsumikan. Although the routine treatment with dexamethasone resulted in a clear and significant reduction in body weight, natsumikan treatment did not have such effects, according to “Extract from peel of Citrus natsudaidai alleviates experimental chronic allergic dermatitis in mice” by Nakayama N, Yamaura K, Shimada M, Ueno K.(6).
7. Breast cancer
In the evaluation of wheather Citrus flavonoids exert a broad spectrum of biological activity, including antiproliferative and proapoptotic effects in cancer cells, indicated that our results strongly imply that bioactive PMFs from orange peel exert proapoptotic activity in human breast cancer cells, which depends on their ability to induce an increase in intracellular Ca(2+ )and thus, activate Ca(2+)-dependent apoptotic proteases, according to “Apoptosis-inducing activity of hydroxylated polymethoxyflavones and polymethoxyflavones from orange peel in human breast cancer cells” by Sergeev IN, Ho CT, Li S, Colby J, Dushenkov S.(7).
8. Adjuvant arthritis (AA)
In the investigation of the effect of the total flavonoids of orange peel (TFO) against adjuvant arthritis (AA) and the underlying mechanism, found that the 75 mg x kg(-1) and 150 mg x kg(-1) TFO treatment obviously decreased the pad thickness and improve the pathological impairment of ankle joint of AA rats. In addition, abnormal elevation of TNF-alpha, IL-1beta and PGE2 in serum and COX-2 expression in synovium tissues of AA rats were markedly repressed by TFO treatment, according to “[Effect and mechanism of total flavonoids of orange peel on rat adjuvant arthritis].[Article in Chinese]” by Chen G, Yin Z, Zheng X.(8).
9. Etc.
Side effects
1. Do not use the herb for a prolonged period of time as it may weaken the body
2. Choose organic Chen pi and soak it in water for several hours and wash it thoroughly before use.
3. Do not use the herb in internal or external bleeding.
4. Etc.
Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/22293353
(2) http://www.ncbi.nlm.nih.gov/pubmed/22279465
(3) http://www.ncbi.nlm.nih.gov/pubmed/22054194
(4) http://www.ncbi.nlm.nih.gov/pubmed/22040922
(5) http://www.ncbi.nlm.nih.gov/pubmed/21950163
(6) http://www.ncbi.nlm.nih.gov/pubmed/22022162
(7) http://www.ncbi.nlm.nih.gov/pubmed/17979096
(8) http://www.ncbi.nlm.nih.gov/pubmed/20707201
In the evaluation of the antioxidant effects of fresh juice and peel extract of Citrus aurantifolia (Christm), found that 5 μl of lime juice didn’t change LDL oxidation. 10 μl of juice inhibited LDL oxidation, and with increasing the juice concentration, LDL was oxidized faster. The higher concentrations of peel extract prevented LDL oxidation better than the lower ones, according to “Antioxidant effects of Citrus aurantifolia (Christm) juice and peel extract on LDL oxidation” by Boshtam M, Moshtaghian J, Naderi G, Asgary S, Nayeri H.(2).
3. Anti bacterial effects
In the observation if orange peel and pulp affected E. coli O157:H7 populations in vivo, found that opulations of inoculated E. coli O157:H7 were reduced by OP treatment throughout the gastrointestinal tract; however, this reduction reached significant levels in the rumen (P < 0.05) of sheep fed 10% OP diets. Cecal and rectal populations of E. coli O157:H7 were reduced (P < 0.05) by inclusion of both 5 and 10% OP diets, according to “Escherichia coli O157:H7 populations in ruminants can be reduced by orange peel product feeding” by Callaway TR, Carroll JA, Arthington JD, Edrington TS, Rossman ML, Carr MA, Krueger NA, Ricke SC, Crandall P, Nisbet DJ.(3) 4. Vascular diseases
In the examination of the effect of tangeretin on platelet-derived growth factor (PDGF)-BB-induced proliferation and migration of rat aortic smooth muscle cells (RASMCs), found that tangeretin could suppress PDGF-BB-induced proliferation and migration of RASMCs through the suppression of PI3K/AKT signaling pathway, and may be a potential candidate for preventing or treating vascular diseases, such as atherosclerosis and restenosis, according to “Tangeretin, a citrus flavonoid, inhibits PGDF-BB-induced proliferation and migration of aortic smooth muscle cells by blocking AKT activation” by Seo J, Lee HS, Ryoo S, Seo JH, Min BS, Lee JH.(4).
5. Antioxidant, anti-inflammatory, and cytotoxic activities
In the isolation of the effects of an aqueous methanolic extract of fruit peel of Citrus pyriformis Hassk. (Rutaceae) resulted in seven compounds including one coumarin (citropten), two limonoids (limonin and deacetylnomilin), and four sterols (stigmasterol, ergosterol, sitosteryl-3-beta-D-glucoside, and sitosteryl-6′-O-acyl-3-beta-D-glucoside), found that The total methanolic extract of the peel and the petroleum ether, dichloromethane, and ethyl acetate fractions were screened for their antioxidant and anti-inflammatory activities. The ethyl acetate fraction exhibited a significant scavenging activity for DPPH free radicals (IC50 = 132.3 microg/mL). The petroleum ether fraction inhibited 5-lipoxygenase with IC50 = 30.6 microg/mL indicating potential anti-inflammatory properties. Limonin has a potent cytotoxic effect against COS7 cells [IC50 = (35.0 +/- 6.1) microM] compared with acteoside as a positive control [IC50 = (144.5 +/- 10.96) microM], according to “Secondary metabolites of ponderosa lemon (Citrus pyriformis) and their antioxidant, anti-inflammatory, and cytotoxic activities” by Hamdan D, El-Readi MZ, Tahrani A, Herrmann F, Kaufmann D, Farrag N, El-Shazly A, Wink M.(5).
6. Chronic allergic dermatitis
In the examination of whether extract from immature natsumikan peel prevents development of chronic allergic dermatitis in mice, found that treatment of natsumikan significantly attenuated the increase in ear swelling and improved dermatitis scores. In addition, increases in serum d-ROM were attenuated by a treatment of natsumikan. Although the routine treatment with dexamethasone resulted in a clear and significant reduction in body weight, natsumikan treatment did not have such effects, according to “Extract from peel of Citrus natsudaidai alleviates experimental chronic allergic dermatitis in mice” by Nakayama N, Yamaura K, Shimada M, Ueno K.(6).
7. Breast cancer
In the evaluation of wheather Citrus flavonoids exert a broad spectrum of biological activity, including antiproliferative and proapoptotic effects in cancer cells, indicated that our results strongly imply that bioactive PMFs from orange peel exert proapoptotic activity in human breast cancer cells, which depends on their ability to induce an increase in intracellular Ca(2+ )and thus, activate Ca(2+)-dependent apoptotic proteases, according to “Apoptosis-inducing activity of hydroxylated polymethoxyflavones and polymethoxyflavones from orange peel in human breast cancer cells” by Sergeev IN, Ho CT, Li S, Colby J, Dushenkov S.(7).
8. Adjuvant arthritis (AA)
In the investigation of the effect of the total flavonoids of orange peel (TFO) against adjuvant arthritis (AA) and the underlying mechanism, found that the 75 mg x kg(-1) and 150 mg x kg(-1) TFO treatment obviously decreased the pad thickness and improve the pathological impairment of ankle joint of AA rats. In addition, abnormal elevation of TNF-alpha, IL-1beta and PGE2 in serum and COX-2 expression in synovium tissues of AA rats were markedly repressed by TFO treatment, according to “[Effect and mechanism of total flavonoids of orange peel on rat adjuvant arthritis].[Article in Chinese]” by Chen G, Yin Z, Zheng X.(8).
9. Etc.
Side effects
1. Do not use the herb for a prolonged period of time as it may weaken the body
2. Choose organic Chen pi and soak it in water for several hours and wash it thoroughly before use.
3. Do not use the herb in internal or external bleeding.
4. Etc.
Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/22293353
(2) http://www.ncbi.nlm.nih.gov/pubmed/22279465
(3) http://www.ncbi.nlm.nih.gov/pubmed/22054194
(4) http://www.ncbi.nlm.nih.gov/pubmed/22040922
(5) http://www.ncbi.nlm.nih.gov/pubmed/21950163
(6) http://www.ncbi.nlm.nih.gov/pubmed/22022162
(7) http://www.ncbi.nlm.nih.gov/pubmed/17979096
(8) http://www.ncbi.nlm.nih.gov/pubmed/20707201
Most Common Disease of elder: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Polymyalgia Arthritis (Rheumatica): The Herbal Formula - Huo-Luo-Xiao-Ling (HLXL) Dan
Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Musculoskeletal disorders (MSDs) are medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed(1).
Types of Musculo-Skeletal disorders in elder(2)
1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalgia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia
Polymyalgia Arthritis (Rheumatica)
Polymalgia Arthritis is defined as a condition a common inflammatory rheumatic disease which causes pain, stiffness and tenderness in large muscles, including muscles shoulders and pelvic girdle as a result of the presence of a synovitis in proximal joints and periarticular structures.
Treatments
B.2. Herbal and Traditional Chinese medicine
Herbal medicine from different cultures have been found effectively in reduced symptoms and treatment for patient with Polymyalagia Arthritis (Rheumatica), including
B.2.2. Herbal and traditional Chinese medicine formulas
4 Huo-Luo-Xiao-Ling (HLXL) Dan
Huo-Luo-Xiao-Ling (HLXL) Dan is a Chinese herbal formula containing Ru Xiang (Boswellia carterii Birdw.), Mo Yao (Commiphora myrrha Engl.), Dang Gui (Angelica sinensis (Oliv.) Diels) and Dan Shen (Salvia miltiorrhiza Bge), used over thousands of year in Chinese history for treatment in alleviating pain caused rheumatoid arthritis (RA) and other inflammatory disorders(505,248)(508,249). On a Phase II clinical trial at Kernan Hospital of the University of Maryland School of Medicine, the herbal formula moderately inhibited hyperanalgesic (severe pain killing)(508,248) with no side effect in comparison to placebo(506,250).
Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
References
(505,248) Chinese Herbal Formula Huo-Luo-Xiao-Ling Dan Protects against Bone Damage in Adjuvant Arthritis by Modulating the Mediators of Bone Remodeling by Siddaraju M. Nanjundaiah,1 David Y.-W. Lee,2 Brian M. Berman,3 and Kamal D. Moudgil(Hindawi Publishing Corporation)
(508,249) Anti-hyperalgesic and anti-inflammatory effects of the modified Chinese herbal formula Huo Luo Xiao Ling Dan (HLXL) in rats by Lao L1, Fan AY, Zhang RX, Zhou A, Ma ZZ, Lee DY, Ren K, Berman B.(PubMed)
(506, 250) Dose Escalation Study Of Chinese Herbs In Osteoarthritis Of The Knee (TCM-OAK)(Clinical trial. Gov)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Types of Musculo-Skeletal disorders in elder(2)
1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalgia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia
Polymyalgia Arthritis (Rheumatica)
Polymalgia Arthritis is defined as a condition a common inflammatory rheumatic disease which causes pain, stiffness and tenderness in large muscles, including muscles shoulders and pelvic girdle as a result of the presence of a synovitis in proximal joints and periarticular structures.
Treatments
B.2. Herbal and Traditional Chinese medicine
Herbal medicine from different cultures have been found effectively in reduced symptoms and treatment for patient with Polymyalagia Arthritis (Rheumatica), including
B.2.2. Herbal and traditional Chinese medicine formulas
4 Huo-Luo-Xiao-Ling (HLXL) Dan
Huo-Luo-Xiao-Ling (HLXL) Dan is a Chinese herbal formula containing Ru Xiang (Boswellia carterii Birdw.), Mo Yao (Commiphora myrrha Engl.), Dang Gui (Angelica sinensis (Oliv.) Diels) and Dan Shen (Salvia miltiorrhiza Bge), used over thousands of year in Chinese history for treatment in alleviating pain caused rheumatoid arthritis (RA) and other inflammatory disorders(505,248)(508,249). On a Phase II clinical trial at Kernan Hospital of the University of Maryland School of Medicine, the herbal formula moderately inhibited hyperanalgesic (severe pain killing)(508,248) with no side effect in comparison to placebo(506,250).
Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
References
(505,248) Chinese Herbal Formula Huo-Luo-Xiao-Ling Dan Protects against Bone Damage in Adjuvant Arthritis by Modulating the Mediators of Bone Remodeling by Siddaraju M. Nanjundaiah,1 David Y.-W. Lee,2 Brian M. Berman,3 and Kamal D. Moudgil(Hindawi Publishing Corporation)
(508,249) Anti-hyperalgesic and anti-inflammatory effects of the modified Chinese herbal formula Huo Luo Xiao Ling Dan (HLXL) in rats by Lao L1, Fan AY, Zhang RX, Zhou A, Ma ZZ, Lee DY, Ren K, Berman B.(PubMed)
(506, 250) Dose Escalation Study Of Chinese Herbs In Osteoarthritis Of The Knee (TCM-OAK)(Clinical trial. Gov)
Most Common Diseases of Men of 50Plus - Prostate Health - The Prostates and Nutritional Supplements
Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Starting at age 40, the levels of the by-product prolactin of testosterone of men increases, stimulating the production of the enzyme 5-alpha reductase that causes the conversion of testosterone to gihydro-testosterones DHT triggering prostate enlargement and other problems. Therefore in order to prevent the symptoms of enlarged prostate is to naturally impend the conversion of testosterone to DHT. Here are some nutritional supplements that help to prevent an enlarged prostate and prostate cancer:
1. Bee pollen
Bee pollen is an antioxidant containing high amounts of flavonoids, zinc and many other elements needed by our bodies. It has an astounding record at reversing prostate cancer and other prostate problems such as enlarged prostate.
2. Prostate glandulars
Animal prostates contain high amounts of zinc that nourishes the human prostate.
3. Alanine
Since alanine is present in prostate fluid, it plays an important role in prostate health. This has been confirmed in some studies that Alanine helps in preventing enlarged prostate and helps in strengthening the immune system.
4. Glutamics acid
The fluid produced by the prostate gland also contains high amounts of glutamic acid, and may play a role in the normal function of the prostate. High dosages of glutamic acid may cause headaches and neurological problems and people with kidney or liver disease should not consume high intakes of amino acids without first consulting with your doctor.
5. Glycine
Glycine is also found in fairly large amounts in the prostate fluid and may for this reason be important in prostate health. It is required to build proteins in the body and synthesis of nucleic acids, the construction of RNA as well as DNA, bile acids and other amino acids in the body. Study shows that glycine, taken withalanine and glutamic acid help to reduced the amount of swelling in the prostate tissue.
6. Lycopene
The substance found in tomatoes, fruits and vegetables can prevent and slow down prostate inflammation and prostate cancer. Study shows that lycopene helps to decrease in DNA the damage to prostate cells. Lycopene also protects against LDL cholesterol oxidation.
Chinese Food Therapy
The Best Way to prevent, treat your disease, including Erectile Dysfunction
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Starting at age 40, the levels of the by-product prolactin of testosterone of men increases, stimulating the production of the enzyme 5-alpha reductase that causes the conversion of testosterone to gihydro-testosterones DHT triggering prostate enlargement and other problems. Therefore in order to prevent the symptoms of enlarged prostate is to naturally impend the conversion of testosterone to DHT. Here are some nutritional supplements that help to prevent an enlarged prostate and prostate cancer:
1. Bee pollen
Bee pollen is an antioxidant containing high amounts of flavonoids, zinc and many other elements needed by our bodies. It has an astounding record at reversing prostate cancer and other prostate problems such as enlarged prostate.
2. Prostate glandulars
Animal prostates contain high amounts of zinc that nourishes the human prostate.
3. Alanine
Since alanine is present in prostate fluid, it plays an important role in prostate health. This has been confirmed in some studies that Alanine helps in preventing enlarged prostate and helps in strengthening the immune system.
4. Glutamics acid
The fluid produced by the prostate gland also contains high amounts of glutamic acid, and may play a role in the normal function of the prostate. High dosages of glutamic acid may cause headaches and neurological problems and people with kidney or liver disease should not consume high intakes of amino acids without first consulting with your doctor.
5. Glycine
Glycine is also found in fairly large amounts in the prostate fluid and may for this reason be important in prostate health. It is required to build proteins in the body and synthesis of nucleic acids, the construction of RNA as well as DNA, bile acids and other amino acids in the body. Study shows that glycine, taken withalanine and glutamic acid help to reduced the amount of swelling in the prostate tissue.
6. Lycopene
The substance found in tomatoes, fruits and vegetables can prevent and slow down prostate inflammation and prostate cancer. Study shows that lycopene helps to decrease in DNA the damage to prostate cells. Lycopene also protects against LDL cholesterol oxidation.
Chinese Food Therapy
The Best Way to prevent, treat your disease, including Erectile Dysfunction
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
The Holistic prevention, management and treatment of Polycystic Ovarian Syndrome: The Stress Response and Management herbal Licorice
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Polycystic Ovarian Syndrome
Polycystic Ovarian Syndrome is defined as endocrinologic diseases among reproductive-age women caused by undeveloped follicles clumping on the ovaries that interferes with the function of the normal ovaries associated with a high risk for metabolic disorder(1) as resulting of enlarged ovaries(2), leading to hormone imbalance(excessive androgen and anti-müllerian hormone (AMH) )(1)(3)(4)(5), induced Hirsutism(6)(7), reproductive disorder(10(12)), risks of type 2 diabetes(9)(10)(11), metabolic syndrome(10)(12) and early cardiovascular disease(8)(13), acne(10)(14), endometrial cancer(18)(19),weight gain and obesity(15)(16)(17). The syndrome effects over 5% of women population or 1 in 20 women.
Unfortunately, according to studies, women with PCOs after the reproductive age, are associated to continuously increase risk of type II diabetes, with no increasingaltered glucose tolerance(20), CVD and hypertension(21).
The prevention and management In Herbal Medicine
Polycystic ovary syndrome (PCOS) is unpreventable in Western medicine. Early diagnosis and treatment may reduce risk of its complications, including infertility, metabolic syndrome, obesity, diabetes, cardiovascular diseases, stroke, etc.
Reduce fat intake less than 30% of total calories with a low proportion of saturated fat and high in fiber from predominantly low-glycaemic-index-carbohydrate foods for patients with PCOs(827a). Calorie intake should be distributed between several meals per day with restricted intake of snacks and drinks(828).
The stress management herbs
Stress in a natural reaction of human fight or fight response induced by pressure due to such as an environmental condition or a stimulus. Long term stress can cause deleterious and cumulative effects on human body(1104), including emotional or cognitive problems, such as an increased risk of attentional deficit/hyperactivity, anxiety, and language delay(1103), especially for people with chronic illness, including women with Polycystic Ovarian Syndrome (PCOs)(1105).
Side effects
1. It may raise blood pressure(1003)(1004(1006)
2. Long term usage of large dosage can also cause edema(1004)(1006) and hypokalemia(1004)(1005)(1006).
3. Overdose can be toxic(106), in inducing rhabdomyolysis or myoglobinuria(1006).
4. Etc.]
Phytochemicals(1058)
1. Glycyrrhizic acid
2. Licochalcone A
3. Licochalcone B
4. Licoflavone
5. Liquiritin
5. Liquiritigenin
7. Isoliquiritigenin
8. Ononins
9. 4′，7-dihydroxyflavone
10. Glycyrrhetinic acid
11. 11-deoxyglycyrrhetinic acid
12. β-sitosterol
13. Etc.
Licorice's phytochemicals, especially glycyrrhizin, have shown efffectively in ameliorated insulin resistance(1059)(1061)(1063)(1064), hyperglycemia(1059)(1060), dyslipidemia(1059)(1063) and oxidative stress(1064) in fructose-induced metabolic syndrome(1059)(1061)(1063) in animal(1059)(1060)(1061)models, probably through its interference of the development of visceral obesity(1064) and cellular derailments that are responsible for the development of metabolic syndrome(1062), anti inflammatory(1062), antioxidant(1062) and an associated with a decrease in tissue lipid deposition(1063) effects].
In chronic unpredictable stress rat model, total flavonoids extract(1153) (licoriceflavonoids, LF) and liquiritin(1154), a phyochemical found in locorice exerted anti-depressive(1153)(1154)(1155) and anti-cognitive impairment(1156) property through total flavonoids extract neurogenesis protective effect(1153) and defense of liquiritin and flavonoids extract against oxidative stress(1154)(1156).
Yokukansan, a traditional Japanese formula, containing licorice showed effectively in amelioration of behavioral symptoms, such as aggressiveness, excitability, and hallucination, through reduced stress increased the serotonin 2A (5-HT2A) receptors density on the plasma membrane of the prefrontal cortex (PFC)(1158).
In high-glucose stress, Glabridin(1159)(1160), an isoflavan from licorice root reduced high-glucose stress(1159)(1160) through its anti inflammatory activity(1159), up-regulates manganese superoxide dismutase, catalase and paraoxonase 2(1160).
In anti oxidative stress, licorice showed to contribute to their overall health promoting pharmacological effects against free radicals(1161)(1162)(1163)(1164) induced diseases such as cancer(1161), cardiac dysfunction(1162) liver diosease(1164), etc., through its anti-inflammatory(1161)(1163)(1164), anti-oxidant activities(1161)(1162)(1163)(1164).
According to University of Western Sydney, Glycyrrhiza glabra, one of Chinese herbs, exhibited strong evidences of neuroprotective activity for promotion of healthy ageing and longevity(1157).
Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
References
(1) Adiposity and metabolic dysfunction in polycystic ovary syndrome by Sam S.(PubMed)
(2) A "kiss" before conception: triggering ovulation with kisspeptin-54 may improve IVF by Young SL.(PubMed)
(3.) Androgen hyperfunction and excessive heterosexual hair growth in women, with special attention to the polycystic ovarian syndrome by Lunde O1.(PubMed)
(4) Expression of anti-Müllerian hormone in letrozole rat model of polycystic ovary syndrome by Du DF1, Li XL, Fang F, Du MR.(PubMed)
(5) [Serum levels of anti-muller hormone in women with polycystic ovary syndromeand healthy women of reproductive age].[Article in Bulgarian] by Parahuleva N, Pehlivanov B, Orbecova M, Deneva T, Uchikova E.(PubMed)
(6) [Current opinions on the etiology and pathophysiology of hirsutism].[Article in Polish] by Krysiak R1, Kedzia A, Okopień B.(PubMed)
(7) The clinical evaluation of hirsutism by Somani N1, Harrison S, Bergfeld WF.(PubMed)
(8) Polycystic ovary syndrome and insulin: our understanding in the past, present and future by Mayer SB1, Evans WS, Nestler JE.(PubMed)
(9) Association of mean platelet volume with androgens and insulin resistance in nonobese patients with polycystic ovary syndrome by Dogan BA1, Arduc A2, Tuna MM1, Karakılıc E1, Dagdelen I1, Tutuncu Y1, Berker D1, Guler S1.(PubMed)
(10) Approach to the patient: contraception in women with polycystic ovary syndrome by Yildiz BO1.(PubMed)
(11) Polycystic ovarian syndrome (PCOS): a significant contributor to the overall burden of type 2 diabetes in women by Talbott EO1, Zborowski JV, Rager JR, Kip KE, Xu X, Orchard TJ.(PubMed)
(12) Prevalence of vitamin D deficiency in Slovak women with polycystic ovary syndrome and its relation to metabolic and reproductive abnormalities by Figurová J1, Dravecká I, Javorský M, Petríková J, Lazúrová I.(PubMed)
(13) Role of Insulin Sensitizers on Cardiovascular Risk Factors in Polycystic Ovarian Syndrome: A Meta-Analysis by Thethi TK1, Katalenich B2, Nagireddy P3, Chabbra P4, Kuhadiya N5, Fonseca V1.(PubMed)
(14) Acne in hirsute women by Lumezi BG1, Pupovci HL1, Berisha VL1, Goçi AU2, Gerqari A3.(PubMed)
(15) Obesity and polycystic ovary syndrome by Naderpoor N1, Shorakae S, Joham A, Boyle J, De Courten B, Teede HJ.(PubMed)
(16) Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan by Teede H1, Deeks A, Moran L.(PubMed)
(17) Metabolic Evidence of Diminished Lipid Oxidation in Women With Polycystic Ovary Syndrome. by Whigham LD1, Butz DE2, Dashti H3, Tonelli M3, Johnson LK1, Cook ME2, Porter WP4, Eghbalnia HR5, Markley JL6, Lindheim SR7, Schoeller DA8, Abbott DH9, Assadi-Porter FM10.(PubMed)
(18) Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis by Barry JA1, Azizia MM1, Hardiman PJ2.(PubMed)
(19) Risk of cancer among women with polycystic ovary syndrome: a Danish cohort study by Gottschau M1, Kjaer SK2, Jensen A1, Munk C1, Mellemkjaer L3.(PubMed)
(20) Polycystic ovary syndrome: metabolic consequences and long-term management by Carmina E1.(PubMed)
(21) Arterial stiffness is increased in asymptomatic nondiabetic postmenopausal women with a polycystic ovary syndrome phenotype by Armeni E1, Stamatelopoulos K, Rizos D, Georgiopoulos G, Kazani M, Kazani A, Kolyviras A, Stellos K, Panoulis K, Alexandrou A, Creatsa M, Papamichael C, Lambrinoudaki I.(PubMed)
(827a) Diet and nutrition in polycystic ovary syndrome (PCOS): pointers for nutritional management by Farshchi H, Rane A, Love A, Kennedy RL(PubMed)
(828) The optimal diet for women with polycystic ovary syndrome? by Marsh K, Brand-Miller J.(PubMed) (1106) Simultaneous Estimation of Withaferin A and Z-Guggulsterone in Marketed Formulation by RP-HPLC by Agrawal P1, Vegda R2, Laddha K2.(PubMed)
(1153) [Antidepressant activities of flavonoids from Glycyrrhiza uralensis and its neurogenesis protective effect in rats].[Article in Chinese] by Fan ZZ1, Zhao WH, Guo J, Cheng RF, Zhao JY, Yang WD, Wang YH, Li W, Peng XD.(PubMed)
(1154) Antidepressant-like effect of liquiritin from Glycyrrhiza uralensis in chronicvariable stress induced depression model rats by Zhao Z1, Wang W, Guo H, Zhou D.(PubMed)
(1155) Metabonomic study on chronic unpredictable mild stress and intervention effects of Xiaoyaosan in rats using gas chromatography coupled with mass spectrometry by Gao X1, Zheng X, Li Z, Zhou Y, Sun H, Zhang L, Guo X, Du G, Qin X.(PubMed)
(1156) Neuroprotective effects of flavonoids extracted from licorice on kainate-induced seizure in mice through their antioxidant properties by Zeng LH1, Zhang HD, Xu CJ, Bian YJ, Xu XJ, Xie QM, Zhang RH.(PubMed)
(1157) An in vitro study of neuroprotective properties of traditional Chinese herbal medicines thought to promote healthy ageing and longevity by Shen B, Truong J, Helliwell R, Govindaraghavan S, Sucher NJ1.(PubMed)
(1158) Yokukansan, a traditional Japanese medicine, decreases head-twitch behaviors and serotonin 2A receptors in the prefrontal cortex of isolation-stressed mice, by Ueki T1, Mizoguchi K2, Yamaguchi T2, Nishi A2, Sekiguchi K2, Ikarashi Y2, Kase Y2.(PubMed)
(1159) Glabridin, an isoflavan from licorice root, downregulates iNOS expression and activity under high-glucose stress and inflammation by Yehuda I1, Madar Z, Leikin-Frenkel A, Tamir S.(PubMed)
(1160) Glabridin, a phytoestrogen from licorice root, up-regulates manganese superoxide dismutase, catalase and paraoxonase 2 under glucose stress by Yehuda I1, Madar Z, Szuchman-Sapir A, Tamir S.(PubMed)
(1161) Anti-inflammatory/Anti-oxidative stress activities and differential regulation of Nrf2-mediated genes by non-polar fractions of tea Chrysanthemum zawadskii and licorice Glycyrrhiza uralensis by Wu TY1, Khor TO, Saw CL, Loh SC, Chen AI, Lim SS, Park JH, Cai L, Kong AN.(PubMed)
(1162) Licorice treatment prevents oxidative stress, restores cardiac function, and salvages myocardium in rat model of myocardial injury by Ojha SK1, Sharma C1, Golechha MJ1, Bhatia J1, Kumari S2, Arya DS3.(PubMed)
(1163) Licochalcone A activates Nrf2 in vitro and contributes to licorice extract-induced lowered cutaneous oxidative stress in vivo by Kühnl J1, Roggenkamp D, Gehrke SA, Stäb F, Wenck H, Kolbe L, Neufang G.(PubMed)
(1164) 18-β Glycyrrhetinic acid alleviates 2-acetylaminofluorene-induced hepatotoxicity in Wistar rats: Role in hyperproliferation, inflammation and oxidative stress by Hasan S1, Khan R1, Ali N1, Khan A1, Rehman M1, Tahir M1, Lateef A1, Nafees S1, Mehdi S1, Rashid S1, Shahid A1, Sultana S2.(PubMed)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Polycystic Ovarian Syndrome
Unfortunately, according to studies, women with PCOs after the reproductive age, are associated to continuously increase risk of type II diabetes, with no increasingaltered glucose tolerance(20), CVD and hypertension(21).
The prevention and management In Herbal Medicine
Polycystic ovary syndrome (PCOS) is unpreventable in Western medicine. Early diagnosis and treatment may reduce risk of its complications, including infertility, metabolic syndrome, obesity, diabetes, cardiovascular diseases, stroke, etc.
Reduce fat intake less than 30% of total calories with a low proportion of saturated fat and high in fiber from predominantly low-glycaemic-index-carbohydrate foods for patients with PCOs(827a). Calorie intake should be distributed between several meals per day with restricted intake of snacks and drinks(828).
The stress management herbs
Stress in a natural reaction of human fight or fight response induced by pressure due to such as an environmental condition or a stimulus. Long term stress can cause deleterious and cumulative effects on human body(1104), including emotional or cognitive problems, such as an increased risk of attentional deficit/hyperactivity, anxiety, and language delay(1103), especially for people with chronic illness, including women with Polycystic Ovarian Syndrome (PCOs)(1105).
Licorice
(See herbal treatment of PCOs for more information)
[Gan Cao is also known as Licorice root. The sweet and neutral herb has been used in TCM as anti allergy(856), anti inflammation(855), anti ulcer(857), anti convulsion(858) agent and to treat stomach weakness, tired and lack of strength, cough with abundance of phlegm, stomach and solar plexus pain, and improve cardiac function(855), etc., as it tonifies the Spleen, benefits the Qi, moistens the Lungs, calms cough, deaf or acute pain, by enhancing all 12 channels(859).
In treatment of PCOs(862), combination of licorice and 100 mg spironolactone showed the activation of the renin-aldosterone system in lowering blood pressure and water (fluid) balance(860). reducing the prevalence of side effects related to the diuretic activity of spironolactone(860). In model rats experiment, Ganshao Paste (CGP), showed the decrease of serum levels of LH, T, and FSH and increase of serum estradiol (E2), and progesterone (P)(861)(865)].
(See The Insulin resistance improvement and/or anti metabolic syndrome herbs: Licorice for more information)
1. PCOs
[ Licorice, in a review of 33 studies of herbal medicine for the management ofpolycystic ovary syndrome (PCOS), showed a stronge evidences in improved metabolic hormone profile and improved fertility outcomes and regulation of ovulation and inhibition of hyperandrogenism in PCOS(860). In model rats experiment, Ganshao Paste (CGP), also decreased serum levels of LH, T, and FSH and increased of serum estradiol (E2), and progesterone (P)(861)(860)(865). According to University of Natural Resources and Life Sciences Vienna, licorice may have a potential effect on metabolic syndrome(862) in women with PCOs.
2. Blow flow
Licorice improves the blood flow in the body by exerting its anti thrombosis(983) and inhibiting the levels of bad cholesterol(984)(985) and triglyceride levels(985) and increasing HDL-cholesterol content(984) in reduced risk of cardiovascular disease(985) and blood stagnation(897) in the abdominal region induced induced infertility(986).
3. Glycyrrhizin
Glycyrrhizin, one of main ingredient from licorice, exhibited anti inflammatory effect pharmacologically in treatment of inflammatory diseases(988)(989)(990), lowered high serum testosterone levels in oligomenorrheic or amenorrheic women, and induced conception in some women(991). As antioxidant, the phytochemical also inhibit irregular cell growth(992)(993) and microbial invasion(994)(995) causes of cancers(992)(993) and infection and inflammation(994)(995) respectively. in adrenocortical function and behavour, it also regulated the levels of cortisol(996), induced by over production of serotonin cause of hormone imbalance(997).
4. Phytoestrogen
See phytoestrogen in black cohosh
[Phytoestrogen found it balck cohosh showed to occupy the estrogen receptor sites in women body(908), through it antiestrogenic and extrogenic effects(909), to induce hormone balancing may result in improving the chance of ovulation and fertility(910)(911)].
5. Lecithin
Lecithin is a fat like substance called a phospholipid improved lipid transfer, cholesterol efflux, HDL genesis and and remodeling at the blood-brain barrier (BBB)(998). against cells from oxidation surrounding the brain(999), in reducing psychotic symptoms(1002) such as stress(1000)(1001), and depression(1002).
(See herbal treatment of PCOs for more information)
[Gan Cao is also known as Licorice root. The sweet and neutral herb has been used in TCM as anti allergy(856), anti inflammation(855), anti ulcer(857), anti convulsion(858) agent and to treat stomach weakness, tired and lack of strength, cough with abundance of phlegm, stomach and solar plexus pain, and improve cardiac function(855), etc., as it tonifies the Spleen, benefits the Qi, moistens the Lungs, calms cough, deaf or acute pain, by enhancing all 12 channels(859).
In treatment of PCOs(862), combination of licorice and 100 mg spironolactone showed the activation of the renin-aldosterone system in lowering blood pressure and water (fluid) balance(860). reducing the prevalence of side effects related to the diuretic activity of spironolactone(860). In model rats experiment, Ganshao Paste (CGP), showed the decrease of serum levels of LH, T, and FSH and increase of serum estradiol (E2), and progesterone (P)(861)(865)].
(See The Insulin resistance improvement and/or anti metabolic syndrome herbs: Licorice for more information)
1. PCOs
[ Licorice, in a review of 33 studies of herbal medicine for the management ofpolycystic ovary syndrome (PCOS), showed a stronge evidences in improved metabolic hormone profile and improved fertility outcomes and regulation of ovulation and inhibition of hyperandrogenism in PCOS(860). In model rats experiment, Ganshao Paste (CGP), also decreased serum levels of LH, T, and FSH and increased of serum estradiol (E2), and progesterone (P)(861)(860)(865). According to University of Natural Resources and Life Sciences Vienna, licorice may have a potential effect on metabolic syndrome(862) in women with PCOs.
2. Blow flow
Licorice improves the blood flow in the body by exerting its anti thrombosis(983) and inhibiting the levels of bad cholesterol(984)(985) and triglyceride levels(985) and increasing HDL-cholesterol content(984) in reduced risk of cardiovascular disease(985) and blood stagnation(897) in the abdominal region induced induced infertility(986).
3. Glycyrrhizin
Glycyrrhizin, one of main ingredient from licorice, exhibited anti inflammatory effect pharmacologically in treatment of inflammatory diseases(988)(989)(990), lowered high serum testosterone levels in oligomenorrheic or amenorrheic women, and induced conception in some women(991). As antioxidant, the phytochemical also inhibit irregular cell growth(992)(993) and microbial invasion(994)(995) causes of cancers(992)(993) and infection and inflammation(994)(995) respectively. in adrenocortical function and behavour, it also regulated the levels of cortisol(996), induced by over production of serotonin cause of hormone imbalance(997).
4. Phytoestrogen
See phytoestrogen in black cohosh
[Phytoestrogen found it balck cohosh showed to occupy the estrogen receptor sites in women body(908), through it antiestrogenic and extrogenic effects(909), to induce hormone balancing may result in improving the chance of ovulation and fertility(910)(911)].
5. Lecithin
Lecithin is a fat like substance called a phospholipid improved lipid transfer, cholesterol efflux, HDL genesis and and remodeling at the blood-brain barrier (BBB)(998). against cells from oxidation surrounding the brain(999), in reducing psychotic symptoms(1002) such as stress(1000)(1001), and depression(1002).
Side effects
1. It may raise blood pressure(1003)(1004(1006)
2. Long term usage of large dosage can also cause edema(1004)(1006) and hypokalemia(1004)(1005)(1006).
3. Overdose can be toxic(106), in inducing rhabdomyolysis or myoglobinuria(1006).
4. Etc.]
Phytochemicals(1058)
1. Glycyrrhizic acid
2. Licochalcone A
3. Licochalcone B
4. Licoflavone
5. Liquiritin
5. Liquiritigenin
7. Isoliquiritigenin
8. Ononins
9. 4′，7-dihydroxyflavone
10. Glycyrrhetinic acid
11. 11-deoxyglycyrrhetinic acid
12. β-sitosterol
13. Etc.
Licorice's phytochemicals, especially glycyrrhizin, have shown efffectively in ameliorated insulin resistance(1059)(1061)(1063)(1064), hyperglycemia(1059)(1060), dyslipidemia(1059)(1063) and oxidative stress(1064) in fructose-induced metabolic syndrome(1059)(1061)(1063) in animal(1059)(1060)(1061)models, probably through its interference of the development of visceral obesity(1064) and cellular derailments that are responsible for the development of metabolic syndrome(1062), anti inflammatory(1062), antioxidant(1062) and an associated with a decrease in tissue lipid deposition(1063) effects].
In chronic unpredictable stress rat model, total flavonoids extract(1153) (licoriceflavonoids, LF) and liquiritin(1154), a phyochemical found in locorice exerted anti-depressive(1153)(1154)(1155) and anti-cognitive impairment(1156) property through total flavonoids extract neurogenesis protective effect(1153) and defense of liquiritin and flavonoids extract against oxidative stress(1154)(1156).
Yokukansan, a traditional Japanese formula, containing licorice showed effectively in amelioration of behavioral symptoms, such as aggressiveness, excitability, and hallucination, through reduced stress increased the serotonin 2A (5-HT2A) receptors density on the plasma membrane of the prefrontal cortex (PFC)(1158).
In high-glucose stress, Glabridin(1159)(1160), an isoflavan from licorice root reduced high-glucose stress(1159)(1160) through its anti inflammatory activity(1159), up-regulates manganese superoxide dismutase, catalase and paraoxonase 2(1160).
In anti oxidative stress, licorice showed to contribute to their overall health promoting pharmacological effects against free radicals(1161)(1162)(1163)(1164) induced diseases such as cancer(1161), cardiac dysfunction(1162) liver diosease(1164), etc., through its anti-inflammatory(1161)(1163)(1164), anti-oxidant activities(1161)(1162)(1163)(1164).
According to University of Western Sydney, Glycyrrhiza glabra, one of Chinese herbs, exhibited strong evidences of neuroprotective activity for promotion of healthy ageing and longevity(1157).
Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
References
(1) Adiposity and metabolic dysfunction in polycystic ovary syndrome by Sam S.(PubMed)
(2) A "kiss" before conception: triggering ovulation with kisspeptin-54 may improve IVF by Young SL.(PubMed)
(3.) Androgen hyperfunction and excessive heterosexual hair growth in women, with special attention to the polycystic ovarian syndrome by Lunde O1.(PubMed)
(4) Expression of anti-Müllerian hormone in letrozole rat model of polycystic ovary syndrome by Du DF1, Li XL, Fang F, Du MR.(PubMed)
(5) [Serum levels of anti-muller hormone in women with polycystic ovary syndromeand healthy women of reproductive age].[Article in Bulgarian] by Parahuleva N, Pehlivanov B, Orbecova M, Deneva T, Uchikova E.(PubMed)
(6) [Current opinions on the etiology and pathophysiology of hirsutism].[Article in Polish] by Krysiak R1, Kedzia A, Okopień B.(PubMed)
(7) The clinical evaluation of hirsutism by Somani N1, Harrison S, Bergfeld WF.(PubMed)
(8) Polycystic ovary syndrome and insulin: our understanding in the past, present and future by Mayer SB1, Evans WS, Nestler JE.(PubMed)
(9) Association of mean platelet volume with androgens and insulin resistance in nonobese patients with polycystic ovary syndrome by Dogan BA1, Arduc A2, Tuna MM1, Karakılıc E1, Dagdelen I1, Tutuncu Y1, Berker D1, Guler S1.(PubMed)
(10) Approach to the patient: contraception in women with polycystic ovary syndrome by Yildiz BO1.(PubMed)
(11) Polycystic ovarian syndrome (PCOS): a significant contributor to the overall burden of type 2 diabetes in women by Talbott EO1, Zborowski JV, Rager JR, Kip KE, Xu X, Orchard TJ.(PubMed)
(12) Prevalence of vitamin D deficiency in Slovak women with polycystic ovary syndrome and its relation to metabolic and reproductive abnormalities by Figurová J1, Dravecká I, Javorský M, Petríková J, Lazúrová I.(PubMed)
(13) Role of Insulin Sensitizers on Cardiovascular Risk Factors in Polycystic Ovarian Syndrome: A Meta-Analysis by Thethi TK1, Katalenich B2, Nagireddy P3, Chabbra P4, Kuhadiya N5, Fonseca V1.(PubMed)
(14) Acne in hirsute women by Lumezi BG1, Pupovci HL1, Berisha VL1, Goçi AU2, Gerqari A3.(PubMed)
(15) Obesity and polycystic ovary syndrome by Naderpoor N1, Shorakae S, Joham A, Boyle J, De Courten B, Teede HJ.(PubMed)
(16) Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan by Teede H1, Deeks A, Moran L.(PubMed)
(17) Metabolic Evidence of Diminished Lipid Oxidation in Women With Polycystic Ovary Syndrome. by Whigham LD1, Butz DE2, Dashti H3, Tonelli M3, Johnson LK1, Cook ME2, Porter WP4, Eghbalnia HR5, Markley JL6, Lindheim SR7, Schoeller DA8, Abbott DH9, Assadi-Porter FM10.(PubMed)
(18) Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis by Barry JA1, Azizia MM1, Hardiman PJ2.(PubMed)
(19) Risk of cancer among women with polycystic ovary syndrome: a Danish cohort study by Gottschau M1, Kjaer SK2, Jensen A1, Munk C1, Mellemkjaer L3.(PubMed)
(20) Polycystic ovary syndrome: metabolic consequences and long-term management by Carmina E1.(PubMed)
(21) Arterial stiffness is increased in asymptomatic nondiabetic postmenopausal women with a polycystic ovary syndrome phenotype by Armeni E1, Stamatelopoulos K, Rizos D, Georgiopoulos G, Kazani M, Kazani A, Kolyviras A, Stellos K, Panoulis K, Alexandrou A, Creatsa M, Papamichael C, Lambrinoudaki I.(PubMed)
(827a) Diet and nutrition in polycystic ovary syndrome (PCOS): pointers for nutritional management by Farshchi H, Rane A, Love A, Kennedy RL(PubMed)
(828) The optimal diet for women with polycystic ovary syndrome? by Marsh K, Brand-Miller J.(PubMed) (1106) Simultaneous Estimation of Withaferin A and Z-Guggulsterone in Marketed Formulation by RP-HPLC by Agrawal P1, Vegda R2, Laddha K2.(PubMed)
(1153) [Antidepressant activities of flavonoids from Glycyrrhiza uralensis and its neurogenesis protective effect in rats].[Article in Chinese] by Fan ZZ1, Zhao WH, Guo J, Cheng RF, Zhao JY, Yang WD, Wang YH, Li W, Peng XD.(PubMed)
(1154) Antidepressant-like effect of liquiritin from Glycyrrhiza uralensis in chronicvariable stress induced depression model rats by Zhao Z1, Wang W, Guo H, Zhou D.(PubMed)
(1155) Metabonomic study on chronic unpredictable mild stress and intervention effects of Xiaoyaosan in rats using gas chromatography coupled with mass spectrometry by Gao X1, Zheng X, Li Z, Zhou Y, Sun H, Zhang L, Guo X, Du G, Qin X.(PubMed)
(1156) Neuroprotective effects of flavonoids extracted from licorice on kainate-induced seizure in mice through their antioxidant properties by Zeng LH1, Zhang HD, Xu CJ, Bian YJ, Xu XJ, Xie QM, Zhang RH.(PubMed)
(1157) An in vitro study of neuroprotective properties of traditional Chinese herbal medicines thought to promote healthy ageing and longevity by Shen B, Truong J, Helliwell R, Govindaraghavan S, Sucher NJ1.(PubMed)
(1158) Yokukansan, a traditional Japanese medicine, decreases head-twitch behaviors and serotonin 2A receptors in the prefrontal cortex of isolation-stressed mice, by Ueki T1, Mizoguchi K2, Yamaguchi T2, Nishi A2, Sekiguchi K2, Ikarashi Y2, Kase Y2.(PubMed)
(1159) Glabridin, an isoflavan from licorice root, downregulates iNOS expression and activity under high-glucose stress and inflammation by Yehuda I1, Madar Z, Leikin-Frenkel A, Tamir S.(PubMed)
(1160) Glabridin, a phytoestrogen from licorice root, up-regulates manganese superoxide dismutase, catalase and paraoxonase 2 under glucose stress by Yehuda I1, Madar Z, Szuchman-Sapir A, Tamir S.(PubMed)
(1161) Anti-inflammatory/Anti-oxidative stress activities and differential regulation of Nrf2-mediated genes by non-polar fractions of tea Chrysanthemum zawadskii and licorice Glycyrrhiza uralensis by Wu TY1, Khor TO, Saw CL, Loh SC, Chen AI, Lim SS, Park JH, Cai L, Kong AN.(PubMed)
(1162) Licorice treatment prevents oxidative stress, restores cardiac function, and salvages myocardium in rat model of myocardial injury by Ojha SK1, Sharma C1, Golechha MJ1, Bhatia J1, Kumari S2, Arya DS3.(PubMed)
(1163) Licochalcone A activates Nrf2 in vitro and contributes to licorice extract-induced lowered cutaneous oxidative stress in vivo by Kühnl J1, Roggenkamp D, Gehrke SA, Stäb F, Wenck H, Kolbe L, Neufang G.(PubMed)
(1164) 18-β Glycyrrhetinic acid alleviates 2-acetylaminofluorene-induced hepatotoxicity in Wistar rats: Role in hyperproliferation, inflammation and oxidative stress by Hasan S1, Khan R1, Ali N1, Khan A1, Rehman M1, Tahir M1, Lateef A1, Nafees S1, Mehdi S1, Rashid S1, Shahid A1, Sultana S2.(PubMed)
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