Friday, June 24, 2016

Phytochemicals in Foods - The Effects of Hydroxytyrosol

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


                               Hydroxytyrosol


Hydroxytyrosol is a phytochemical in the class of Tyrosol esters, belonging to the group of Phenolic compounds found abundantly in olive oil.

Health Benefits

1. Longevity
In the determination if white wine and its cardioprotective components possess anti-aging properties by feeding rats with these compounds, found that the hearts expressed SirT, FoxO, and PBEF in the order of white wine>resveratrol>tyrosol>hydroxytyrosol>red wine, while cardioprotection shown by reduction of infarct size and cardiomyocyte apoptosis followed a different pattern: resveratrol>red wine>hydroxytyrosol>white wine>tyrosol, suggesting the existence of different signaling mechanisms for the induction of longevity and survival, according to " Expression of the longevity proteins by both red and white wines and their cardioprotective components, resveratrol, tyrosol, andhydroxytyrosol" by
Mukherjee S, Lekli I, Gurusamy N, Bertelli AA, Das DK.(1)

2. Anti breast cancer
In the investigation of hydroxytyrosol and tyrosol's effects in human breast cell lines, found that
hydroxytyrosol decreases the intracellular reactive oxygen species (ROS) level in MCF10A cells but not in MCF7 or MDA-MB-231 cells while very high amounts of tyrosol is needed to decrease the ROS level in MCF10A cells. Interestingly,hydroxytyrosol prevents oxidative DNA damage in the three breast cell lines, according to "Hydroxytyrosol Protects against Oxidative DNA Damage in Human Breast Cells" by Warleta F, Quesada CS, Campos M, Allouche Y, Beltrán G, Gaforio JJ.(2)

3. Antioxidants
In the determination of the antioxidant and protective properties of crude extract and fractions from Fructus Ligustri Lucidi (FLL) against hydrogen peroxide (H(2)O(2))-induced oxidative damage in SH-SY5Y cells, found that following exposure of cells to H(2)O(2),there was a marked decrease in cell survival and intracellular antioxidant enzymes, and then intracellular oxidative stress, the level of lipid peroxidation, and caspase-3 activity were increased. Simultaneous treatment with the EtOAc fraction blocked these H(2)O(2)-induced cellular events.Hydroxytyrosol and salidroside are major components of the EtOAc fraction, according to "Antioxidant phenolic profile from ethyl acetate fraction of Fructus Ligustri Lucidi with protection against hydrogen peroxide-induced oxidative damage in SH-SY5Y cells" by Ju HY, Chen SC, Wu KJ, Kuo HC, Hseu YC, Ching H, Wu CR.(3)

4. anti-inflammatory effects
In the investigation of the topical delivery features of this new set of antioxidant molecules as a function of their permeation profiles through the human stratum corneum and viable epidermis membranes, found that encouraging results prompt further investigations on the polyfunctional role that hydroxytyrosol conjugates could have as agents in both anti-inflammatory and antioxidant therapies, according to "Lipophilic hydroxytyrosol esters: fatty acid conjugates for potential topical administration" by Procopio A, Celia C, Nardi M, Oliverio M, Paolino D, Sindona G.(4)

5. Chronic colitis
In the randomized study of Six-week-old mice of three dietary groups: standard, EVOO and hydroxytyrosol-enriched EVOO. After 30 days, mice that were exposed to 3% DSS for 5 days developed acute colitis that progressed to severe chronic inflammation during a regime of 21 days of water, found that EVOO diets exerted a noteworthy beneficial effect in chronic DSS-induced colitis by cytokine modulation and COX-2 and iNOS reduction via downregulation of p38 MAPK. In addition to the beneficial effect by EVOO, supplementation of the diet with hydroxytyrosol may improve chronic colitis through iNOS downregulation plus its antioxidant capacity, according to "Influence of extra virgin olive oil diet enriched withhydroxytyrosol in a chronic DSS colitis model" by Sánchez-Fidalgo S, Sánchez de Ibargüen L, Cárdeno A, Alarcón de la Lastra C.(5)

6. Anti-proliferative and pro-apoptotic activities
In the classification of the role played by H(2)O(2) in the chemopreventive activities of 3,4-DHPEA on breast (MDA and MCF-7), prostate (LNCap and PC3) and colon (SW480 and HCT116) cancer cell lines and the investigation of the effects of cell culture medium components and the possible mechanisms at the basis of the H(2)O(2)-producing properties of 3,4-DHPEA,
found that the H(2)O(2)-inducing ability of 3,4-DHPEA is completely prevented by pyruvate and that the exposure of cells to conditions not supporting the H(2)O(2) accumulation (addition of either catalase or pyruvate to the culture medium) inhibited the anti-proliferative effect of 3,4-DHPEA. Accordingly, the sensitivity of the different cell lines to the anti-proliferative effect of 3,4-DHPEA was inversely correlated with their ability to remove H(2)O(2) from the culture medium, according to "Anti-proliferative and pro-apoptotic activities of hydroxytyrosol on different tumour cells: the role of extracellular production of hydrogen peroxide" by Fabiani R, Sepporta MV, Rosignoli P, De Bartolomeo A, Crescimanno M, Morozzi G.(6)

7. Huntington's disease
In the verification of whether extra-virgin olive oil (EVOO) exerted a brain antioxidant effect, protecting the brain against the oxidative stress caused by 3-nitropropionic acid (3NP).
found that EVOO and HT reduces lipid peroxidation product levels and blocks the GSH depletion prompted by 3NP in both striatum and rest of the brain in Wistar rats. In addition, EVOO blocks and reverses the effect of 3NP on succinate dehydrogenase activity. In brief, the data obtained indicate that EVOO and HT act as a powerful brain antioxidant, according to "Olive oil reduces oxidative damage in a 3-nitropropionic acid-induced Huntington's disease-like rat model" by Tasset I, Pontes AJ, Hinojosa AJ, de la Torre R, Túnez I.(7)

8. Antimicrobial activity
In the assesment of antimicrobial effects, in vitro that wastewaters from alpeorujo oil extraction have against phytopathogenic bacteria and fungi, found that the bactericidal effect was due to the joint action of low molecular mass phenolic compounds, although neither hydroxytyrosol, its glucosides, hydroxytyrosol glycol, nor a glutaraldehyde-like compound individually explained this bioactivity, according to "Antimicrobial activity of olive solutions from stored Alpeorujo against plant pathogenic microorganisms" by Medina E, Romero C, de Los Santos B, de Castro A, Garcia A, Romero F, Brenes M.(8)

9. Osteoporosis symptoms
In the evaluation of the effects of oleuropein, hydroxytyrosol and tyrosol, the major polyphenols in olives, on bone formation using cultured osteoblasts and osteoclasts, and on bone loss in ovariectomized mice, found that the olive polyphenols oleuropein and hydroxytyrosol may have critical effects on the formation and maintenance of bone, and can be used as effective remedies in the treatment of osteoporosis symptoms, according to "Olive polyphenolhydroxytyrosol prevents bone loss" by Hagiwara K, Goto T, Araki M, Miyazaki H, Hagiwara H.(9)

10. Anti-platelet effects
In the investigation of the effects of alperujo extract, an olive oil production waste product containing the majority of polyphenols found in olive fruits, through measurement of effects on platelet aggregation and activation in isolated human platelets, and through identification of changes in the platelet proteome, found that Alperujo extract (40 mg/L) significantly decreased in vitro ADP- (p = 0.002) and TRAP- (p = 0.02) induced platelet activation as measured by the flow cytometry using the antibody for p-selectin (CD62p), but it did not affect the conformation of the fibrinogen receptor as measured by flow cytometry using the antibodies for anti-fibrinogen, CD42a and CD42b. Alperujo extract (100 mg/L) inhibited both collagen- and TRAP-induced platelet aggregation by 5% (p < 0.05), and a combination of hydroxytyrosol and 3,4-dihydroxyphenylglycol, according to "Anti-platelet effects of olive oil extract: in vitro functional and proteomic studies" by de Roos B, Zhang X, Rodriguez Gutierrez G, Wood S, Rucklidge GJ, Reid MD, Duncan GJ, Cantlay LL, Duthie GG, O'Kennedy N.(10)

11. Cardiovascular disease
In the evaluation of whether the consumption of hydroxytyrosol-enriched sunflower oil (HSO) improves certain CVD biomarker values, found that the HSO group displayed a significantly higher level (P < 0·01) of arylesterase activity and significantly lower levels of oxidised LDL and sVCAM-1 (both P < 0·05) than the control group. These results suggest that HSO may help prevent CVD, according to "Effects of hydroxytyrosol-enriched sunflower oil consumption on CVD risk factors" by Vázquez-Velasco M, Esperanza Díaz L, Lucas R, Gómez-Martínez S, Bastida S, Marcos A, Sánchez-Muniz FJ.(11)

12. Etc.

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity 
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/19071213
(2) http://www.ncbi.nlm.nih.gov/pubmed/22254082
(3) http://www.ncbi.nlm.nih.gov/pubmed/22142696
(4) http://www.ncbi.nlm.nih.gov/pubmed/22014120
(5) http://www.ncbi.nlm.nih.gov/pubmed/21874330
(6) http://www.ncbi.nlm.nih.gov/pubmed/21805082
(7) http://www.ncbi.nlm.nih.gov/pubmed/21756531
(8) http://www.ncbi.nlm.nih.gov/pubmed/21630653
(9) http://www.ncbi.nlm.nih.gov/pubmed/21539839
(10) http://www.ncbi.nlm.nih.gov/pubmed/21197537
(11) http://www.ncbi.nlm.nih.gov/pubmed/21138606

The Holistic management and treatment of Polycystic Ovarian Syndrome: The Dietary Suggestion(Part II)

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

                Polycystic Ovarian Syndrome

Polycystic Ovarian Syndrome is defined as endocrinologic diseases among reproductive-age women caused by undeveloped follicles clumping on the ovaries that interferes with the function of the normal ovaries associated with a high risk for metabolic disorder(1) as resulting of enlarged ovaries(2), leading to hormone imbalance(excessive androgen and anti-müllerian hormone (AMH) )(1)(3)(4)(5), induced Hirsutism(6)(7), reproductive disorder(10(12)), risks of type 2 diabetes(9)(10)(11), metabolic syndrome(10)(12) and early cardiovascular disease(8)(13), acne(10)(14), endometrial cancer(18)(19),weight gain and obesity(15)(16)(17). The syndrome effects over 5% of women population or 1 in 20 women.
Unfortunately, according to studies, women with PCOs after the reproductive age, are associated to continuously increase risk of type II diabetes, with no increasingaltered glucose tolerance(20), CVD and hypertension(21).


                In Traditional Chinese Perspective


While conventional medicine focus of using synthetic medication to induce ovulation and assisted artificial insemination for infertility couple, if the medicine fail, traditional Chinese medicine views polycystic ovarian syndrome in different approaches.
Polycystic ovary syndrome, according to traditional Chinese medicine is a medical condition characterized by accumulative of fluid over a prolonged period of time causes of dampness and phlegms(247a)(247b) build up on the ovaries due to the effects of vary differentiations, affecting not only
the women’s menstrual cycle, but also ovulation and fertility(1247a)(247b).

                  The Dietary Suggestion 


6. Eat organic meats only
Grass-fed and grain-fed cattle have shown to significantly improve the fatty acid (FA) composition(1273)(1274) and antioxidant content of beef(1273). According to Norwegian University of Life Sciences, Pig feeds rich in rapeseed products contains high concentration of EPA, DPA, and DHA of which have shown to benefit to over health for the consumer(1272).

7. Intake of berries has shown to contribute to beneficial metabolic effects in preventing obesity(1275) and related disorders(1275)(1278)(1279), such as ameliorating total cholesterol and LDL-cholesterol(1276), hyperglycemia(1277) and insulin sensitivity(1277), lowering fasting insulin level(1275),......

8. Intake cinnamon daily can improve insulin resistance and PCOs related metabolic syndrome
(See the Insulin resistance improvement and/or anti metabolic syndrome herb: Cinnamon for more information)
[Cinnamon is a spice derived from the inner bark of tree, native to South East Asia, of over 300 species of the genus Cinnamomum, belongings to the familyLauraceae used in herbal and traditional medicine as anti-microbial agent(1087) and to improve reproductive organs(1088), prevent flatulence(1089) and menstrual cramping(1087), treat gastrointestinal complaints(1089), diarrhea(1087), bad breath(1090), headache(1087), etc.(1086)(1087).

Ingredients(1087)
1. Cinnamic aldehyde
2.Cinnamyl acetate
3. Eugenol
4. Aldehyde
5. Pinene
6. Coumarins
7. Cinnzeylanol
8. Cinnzeylanine
9. Safrol
10. Methylhydroxy chalcone polymer (MHCP)

Epidemiological studies suggested that cinnamon consist a significant anti insulin resistance(1091)(1092)(1094) and anti metabolic syndrome(1093)(1094)(1095)(1096)(1097) properties, such as lowering total cholesterol(1093), low-density lipoprotein cholesterol(1093) and improving high-density lipoprotein cholesterol(1093), may be due to its antihyperglycaemic (1091)(1093) and potential to reduce postprandial blood glucose levels(1091)(1092), liver fat(1098) and and improved glucose homeostasis(1098) properties, by regulating the mechanisms of-medicated glucose and lipid metabolism(1099), such as decreased the mRNA expression of inflammatory cytokine(TNF-alpha) in adipose tissue(1100) and upregulated mRNA expression of insulin-regulated membrane trafficking(1100) and whole body glucose homeostasi(GLUT-4) in skeletal muscle(1100)].

9. Adding bitter Melon and fenugreek into your diet
Epidemiological studies suggested that bitter melon displays a modest hypoglycemic effect(1280)(1281)(1283)and anti related complications in metabolic syndrome(1281)(1282).
Fenugreek not only showed to promote sexual arousal and desire in women, probly through its regulationj of total and free testosterone and other hormone(1284) but also exhibited hypoglycemic and hypocholesterolemic effects in in a dose-dependent manner(1285)

10. Insure adequate fiber intake through eating a lots of fresh vegetables and whole grains.
High-fiber diets, especially of the soluble variety, and soluble fiber supplements has been recommended by several national diabetes associations management of the plasma glucose concentration in individuals with diabetes(1286)(1288) as it offers some improvement in carbohydrate metabolism(1287).

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library,
 Eat Yourself Healthy With The Best of the Best Nature Has to Offer

References
(1) Adiposity and metabolic dysfunction in polycystic ovary syndrome by Sam S.(PubMed)
(2) A "kiss" before conception: triggering ovulation with kisspeptin-54 may improve IVF by Young SL.(PubMed)
(3.) Androgen hyperfunction and excessive heterosexual hair growth in women, with special attention to the polycystic ovarian syndrome by Lunde O1.(PubMed)
(4) Expression of anti-Müllerian hormone in letrozole rat model of polycystic ovary syndrome by Du DF1, Li XL, Fang F, Du MR.(PubMed)
(5) [Serum levels of anti-muller hormone in women with polycystic ovary syndromeand healthy women of reproductive age].[Article in Bulgarian] by Parahuleva N, Pehlivanov B, Orbecova M, Deneva T, Uchikova E.(PubMed)
(6) [Current opinions on the etiology and pathophysiology of hirsutism].[Article in Polish] by Krysiak R1, Kedzia A, Okopień B.(PubMed)
(7) The clinical evaluation of hirsutism by Somani N1, Harrison S, Bergfeld WF.(PubMed)
(8) Polycystic ovary syndrome and insulin: our understanding in the past, present and future by Mayer SB1, Evans WS, Nestler JE.(PubMed)
(9) Association of mean platelet volume with androgens and insulin resistance in nonobese patients with polycystic ovary syndrome by Dogan BA1, Arduc A2, Tuna MM1, Karakılıc E1, Dagdelen I1, Tutuncu Y1, Berker D1, Guler S1.(PubMed)
(10) Approach to the patient: contraception in women with polycystic ovary syndrome by Yildiz BO1.(PubMed)
(11) Polycystic ovarian syndrome (PCOS): a significant contributor to the overall burden of type 2 diabetes in women by Talbott EO1, Zborowski JV, Rager JR, Kip KE, Xu X, Orchard TJ.(PubMed)
(12) Prevalence of vitamin D deficiency in Slovak women with polycystic ovary syndrome and its relation to metabolic and reproductive abnormalities by Figurová J1, Dravecká I, Javorský M, Petríková J, Lazúrová I.(PubMed)
(13) Role of Insulin Sensitizers on Cardiovascular Risk Factors in Polycystic Ovarian Syndrome: A Meta-Analysis by Thethi TK1, Katalenich B2, Nagireddy P3, Chabbra P4, Kuhadiya N5, Fonseca V1.(PubMed)
(14) Acne in hirsute women by Lumezi BG1, Pupovci HL1, Berisha VL1, Goçi AU2, Gerqari A3.(PubMed)
(15) Obesity and polycystic ovary syndrome by Naderpoor N1, Shorakae S, Joham A, Boyle J, De Courten B, Teede HJ.(PubMed)
(16) Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan by Teede H1, Deeks A, Moran L.(PubMed)
(17) Metabolic Evidence of Diminished Lipid Oxidation in Women With Polycystic Ovary Syndrome. by Whigham LD1, Butz DE2, Dashti H3, Tonelli M3, Johnson LK1, Cook ME2, Porter WP4, Eghbalnia HR5, Markley JL6, Lindheim SR7, Schoeller DA8, Abbott DH9, Assadi-Porter FM10.(PubMed)
(18) Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis by Barry JA1, Azizia MM1, Hardiman PJ2.(PubMed)
(19) Risk of cancer among women with polycystic ovary syndrome: a Danish cohort study by Gottschau M1, Kjaer SK2, Jensen A1, Munk C1, Mellemkjaer L3.(PubMed)
(20) Polycystic ovary syndrome: metabolic consequences and long-term management by Carmina E1.(PubMed)
(21) Arterial stiffness is increased in asymptomatic nondiabetic postmenopausal women with a polycystic ovary syndrome phenotype by Armeni E1, Stamatelopoulos K, Rizos D, Georgiopoulos G, Kazani M, Kazani A, Kolyviras A, Stellos K, Panoulis K, Alexandrou A, Creatsa M, Papamichael C, Lambrinoudaki I.(PubMed)
(1247a) A Comprehensive Treatment of Polycystic Ovarian Syndrome (PCOS) bny by Liqin Zhao
(1247b) Polycystic Ovary Syndrome - a TCM Perspective by Donna Dupre, L.Ac.
(1272) Pig feeds rich in rapeseed products and organic selenium increased omega-3 fatty acids and selenium in pork meat and backfat by Gjerlaug-Enger E1, Haug A2, Gaarder M3, Ljøkjel K4, Stenseth RS5, Sigfridson K6, Egelandsdal B7, Saarem K3, Berg P3.(PubMed)
(1273) A review of fatty acid profiles and antioxidant content in grass-fed andgrain-fed beef by Daley CA1, Abbott A, Doyle PS, Nader GA, Larson S.(PubMed)
(1274) Effect of feeding systems on omega-3 fatty acids, conjugated linoleic acid and trans fatty acids in Australian beef cuts: potential impact on human health by Ponnampalam EN1, Mann NJ, Sinclair AJ.(PubMed)
(1275) Evaluation of Beneficial Metabolic Effects of Berries in High-Fat Fed C57BL/6J Mice by Heyman L1, Axling U1, Blanco N2, Sterner O2, Holm C1, Berger K1.(PubMed)
(1276) Polyphenol-rich bilberry ameliorates total cholesterol and LDL-cholesterol when implemented in the diet of Zucker diabetic fatty rats. Brader L1, Overgaard A1, Christensen LP2, Jeppesen PB1, Hermansen K1.(PubMed)
(1277) Dietary anthocyanin-rich bilberry extract ameliorates hyperglycemia and insulin sensitivity via activation of AMP-activated protein kinase in diabetic mice by Takikawa M1, Inoue S, Horio F, Tsuda T.(PubMed)
(1278) Effects of ellagitannin-rich berries on blood lipids, gut microbiota, and urolithin production in human subjects with symptoms of metabolic syndrome by Puupponen-Pimiä R1, Seppänen-Laakso T, Kankainen M, Maukonen J, Törrönen R, Kolehmainen M, Leppänen T, Moilanen E, Nohynek L, Aura AM, Poutanen K, Tómas-Barberán FA, Espín JC, Oksman-Caldentey KM.(PubMed)
(1279) Different berries and berry fractions have various but slightly positive effects on the associated variables of metabolic diseases on overweight and obese women by Lehtonen HM1, Suomela JP, Tahvonen R, Yang B, Venojärvi M, Viikari J, Kallio H.(PubMed)
(1280) The effect of bitter melon (Mormordica charantia) in patients with diabetes mellitus: a systematic review and meta-analysis by Yin RV1, Lee NC1, Hirpara H1, Phung OJ1.(PubMed)
(1281) Hypoglycemic effect of bitter melon compared with metformin in newly diagnosed type 2 diabetes patients by Fuangchan A1, Sonthisombat P, Seubnukarn T, Chanouan R, Chotchaisuwat P, Sirigulsatien V, Ingkaninan K, Plianbangchang P, Haines ST.(PubMed)
(1282) Beneficial role of bitter melon supplementation in obesity and related complications in metabolic syndrome by Alam MA1, Uddin R2, Subhan N3, Rahman MM1, Jain P1, Reza HM1.(PubMed)
(1283) Protective effect of Momordica charantia fruit extract on hyperglycaemia-induced cardiac fibrosis by Abas R1, Othman F2, Thent ZC2.(PubMed)(1284) Influence of a Specialized Trigonella foenum-graecum Seed Extract (Libifem), on Testosterone, Estradiol and Sexual Function in Healthy Menstruating Women, a Randomised Placebo Controlled Study by Rao A1, Steels E, Beccaria G, Inder WJ, Vitetta L., (PubMed)
(1285) Effect of Trigonella foenum-graecum (fenugreek) extract on blood glucose, blood lipid and hemorheological properties in streptozotocin-induced diabetic rats by Xue WL1, Li XS, Zhang J, Liu YH, Wang ZL, Zhang RJ.(PubMed)
(1286) Dietary fiber in management of diabetes by Vinik AI1, Jenkins DJ.(PubMed)
(1287) Dietary fiber in the management of diabetes by Nuttall FQ1.(PubMed)
(1288) Role of guar and dietary fibre in the management of diabetes mellitus by Cohen M, Leong VW, Salmon E, Martin FI.(PubMed)

The Smoothie of Ginger and Walnut or Ginger, Walnut and Low Fat Cow Milk for Reduced Risk of Preterm Labor

Kyle J. Norton(Scholar, master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for reduced risk of preterm labor
Preterm labor without preeclampsia
Yield: 2 serving (about 8 ounce each)
11/2  cup walnuts
1 cup of herbal ginger tea

Preterm labor with preeclampsia
11/2  cup walnuts
1/2 cup of herbal ginger tea
 1/2 cups of low fat cow milk

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately

The finding of a natural source for reduced risk and treatment of preterm labor has encountered many obstacles, many ingredients showed initially the promising result in animal studies have not produced same potentials in either large sample size and mutli centers human trials.

Preterm labor is defined as the condition in which the uterine contractions of sufficient frequency and intensity to effect progressive effacement and dilation of the cervix prior to term gestation as a result of the affect of the over production of thyroid hormone.
Walnut with rich in vitamin B6 induced the hormonal balance of progesterone and estrogen may plays an important role for reduced risk and treatment of miscarriage due to  expression of low levels of progesterone(3).
Progesterone deficiency in pregnant women is associated to increased risk of preterm labor through induction of uterine activities(1).
In over 50% of cases of premature labour, levels of plasma progesterone during lay below the mean for gestation though within the normal range(2), but gave no consistent suggest of the onset of premature labour(2).

Ginger,  is the genus Zingiber, belongings to the family Zingiberaceae, native to Tamil, used in traditional and Chinese medicine to treat dyspepsia, gastropsimilar to those of anticoagulants in
making your blood thinner involved late-term losses and earlier miscarriages(4).
In a cohort of 731 women of second trimester amniocentesis prospectively followed to delivery, thrombin generation is found to induce early in pregnancy and subsequent preterm delivery(5).
In fact, anticoagulation may provide benefit for women both as prophylaxis and as treatment for venous thrombosis during pregnancy, according to dr. Pabinger I1 and Dr.Grafenhofer H.(6).
Furthermore, in women preeclampsia, intake of milk with high amount of calcium may also reduced risk of preterm labor(7).
According to the McMaster University, pregnant women at risk of preeclampsia should consider taking calcium, but calcium supplementation during pregnancy leads to an important reduction in systolic and diastolic blood pressure andpreeclampsia may need needed to confirm calcium's impact on maternal and fetal morbidity(8).

The smoothie of Ginger and Walnut or Ginger, Walnut and Low Fat Cow Milk may hold a key for further studies in production of effective natural ingredients for prevention and treatment of preterm labor in pregnancy without inducing adverse effects.
Women who are at increased risk of preterm labor in pregnancy, due to family history, ... should drink at least one cup daily, depending to the digestive toleration.



References
(1) Progesterone deficiency and premature labour by Csapo AI, Pohanka O, Kaihola HL.(PubMed)
(2) Endocrine changes in premature labour by Tamby Raja RL, Anderson AB, Turnbull AC.(PubMed)
(3) Progestogens in the prevention of miscarriage by Carp HJ.(PubMed)
(4) (1) The Role of Anticoagulants in the Prevention of Pregnancy Complications.
Leaf RK1, Connors JM2.(PubMed)
(5) Is thrombin activation predictive of subsequent preterm delivery? by Vidaeff AC1, Monga M, Ramin SM, Saade G, Sangi-Haghpeykar H.(PubMed)
(6) Anticoagulation during pregnancy by Pabinger I1, Grafenhofer H.(PubMed)
(7) Pre-eclampsia: reducing the risk with calcium supplements by Mackillop L1.(PubMed)
(8) Effect of calcium supplementation on pregnancy-induced hypertension and preeclampsia: a meta-analysis of randomized controlled trials by Bucher HC1, Guyatt GH, Cook RJ, Hatala R, Cook DJ, Lang JD, Hunt D.(PubMed)

Most Common Diseases of 50 Plus - Upper gastrointestinal disorders: Gastro-esophageal reflux disease (GERD) - Treatments In Conventional medicine Perspective

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Upper gastrointestinal (GI) diseases

The prevalence of upper gastrointestinal (GI) diseases is increasing in subjects aged 65 years and over. Pathophysiological changes in esophageal functions that occur with aging may, at least in part, be responsible for the high prevalence of
1. Gastro-esophageal reflux disease (GERD) in old age.

2. The incidence of gastric and duodenal ulcers and their bleeding complications is increasing in old-aged populations worldwide.

3. H. pylori infection in elderly patients with H. pylori-associated peptic ulcer disease and severe chronic gastritis.

4. Almost 40% of GU and 25% of DU in the elderly patients are associated with the use of NSAID(1) and/or aspirin(2).(a)

        Gastro-esophageal reflux disease (GERD)



Gastroesophageal reflux disease (GERD), also known as gastro-oesophageal reflux disease (GORD), gastric reflux disease, or acid reflux disease, is defined as a chronic condition of liquid stomach acid refluxing back up from the stomach into the esophagus, causing heartburn. According to the study of “Updated guidelines for the diagnosis and treatment of gastroesophageal reflux disease.” by DeVault KR, Castell DO; American College of Gastroenterology, GERD is defined as symptoms or mucosal damage produced by the abnormal reflux of gastric contents into the esophagus.  

                                   The Treatments

In Conventional medicine
A.1. Medication
1. Proton-pump inhibitors
Proton-pump inhibitors including omeprazole, esomeprazole, pantoprazole, are used to reduce the production of gastric acid in the stomach.

2. H2 receptor blockers
H2 receptor blockers include ranitidine, famotidine, cimetidine, etc.. In a study of ” Meta-analysis: the efficacy of over-the-counter gastro-oesophageal reflux disease therapies.” by Tran T, Lowry AM, El-Serag HB., posted in US National Library of Medicine National Institutes of Health , researchers found that Over-the-counter medications are effective in treating symptomatic gastro-oesophageal reflux disease. Compared with the placebo response, which ranged between 37% and 64%, the relative benefit increase was up to 41% with histamine-2 receptor antagonists, 60% with alginate/antacid combinations, and 11% with antacids.

3. 5HT4 agonist
According to the study of “The effect of mosapride, a novel prokinetic, on acid reflux variables in patients with gastro-oesophageal reflux disease.” by Ruth M, Hamelin B, Röhss K, Lundell L., posted in US National Library of Medicine National Institutes of Health, researchers found that
Mosapride 40 mg q.d.s. is effective in decreasing acid reflux in the oesophagus in patients with GERD and therefore has the potential to be effective in the treatment of this disease.

4. GABA-B Receptor Agonists
In an article of “Medical Management of GERD” From Medscape Gastroenterology by Ronnie Fass, MD, FACP, FACG., the author wrote that Richard Holloway from Adelaide, Australia, reviewed the current studies assessing the role of baclofen, a GABA-B agonist, in the treatment of patients with GERD. He emphasized that the drug inhibits 34% to 60% of the TLESRs and improves basal lower esophageal sphincter pressure.

5. Antacids
Antacids are oral medicine used to relieve symptom of heartburn of gastroesophageal reflux disease (GERB).

4. Promotility Agents
Promotility Agents are used to improve GERD symptoms for patients with slow gastric emptying by stimulating the muscles of the gastrointestinal tract to reduce acid reflux into the esophagus.
5. Etc.

A.2. Surgery: Fundoplication Surgery
The aim of the sugery is to reduce heartburn caused by acid reflux, in severe case of inflammation, hiatal hernia, damage of esophagus, etc.. Fundoplication surgery is the procedure to treat Gastroesophageal Reflux Disease (GERD) by strengthening the valve between the esophagus and stomach as the upper curve of the stomach is wrapped and satured around the lower end of the esophagus to prevent acid from backing up into the esophagus with a laparoscopic with a small tunnel made from the stomach muscle to allow foods of the lower part of the esophagus to pass through. The sugery is also by times for the esophagus to heal. Acccording to the artilce of “Barrett’s esophagus: the role of laparoscopic fundoplication” by Abbas E. Abbas MD, Claude Deschamps MD, Stephen D. Cassivi MD, Mark S. Allen MD, Francis C. Nichols, III MD, Daniel L. Miller MD and Peter C. Pairolero MD, posted in ScienceDirect, researcher found that laparoscopic fundoplication is effective in controlling symptoms in the majority of patients with BE. While disappearance of BE may occur in some patients, the possibility of developing esophageal adenocarcinoma is not eliminated by laparoscopic fundoplication. Therefore, endoscopic surveillance should continue.


General Health: Detoxification - The Detoxified Herbal Medicine

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The Detoxified Herbal Medicine

American diet contains high saturated fat, trans fat, and other harmful substances such as sugar, caffeine, pesticides, additive substances, and less in fruits and vegetables. These types of harmful substances is toxic. Our body's detoxifying functions try to get rid of them everyday, when they fail it causes a disruption of hormone production, damaging our body's detoxification organs and weakens our immune system resulting in hormone imbalance and many chronic illness consequently. In this article, we will discuss how to detoxify your body with herbs.

1. Garlic extract
Garlic extract is a widely used medication in the world. It has many times been proven record in preventing and treating heart disease, increasing circulation of blood flow, protecting our kidney and liver from being damage by the forming of free radicals in the organs. It also helps to strengthen our system's fighting against the degeneration of our body.

2. Gotu Kola
Gotu Kola is also known as cetenlla asiatica. It is said to have a strong effect in treating nervous system disorder caused by inflammation, and improving alertness and memory. It's antioxidant property also helps to rejuvenate our body against the forming of free radicals and early aging.

3. Astragalus
Astragalus contains antioxidants that has been used in traditional Chinese medicine for strengthening our body in fighting against diseases and protecting cells from free radicals. it also has anti-virus and anti-bacteria properties, and restores our body's energy.

4. Bee Pollen
Bee pollen is said to contain all the essential components of life. It helps not only to correct the deficient or unbalanced nutrition but also improves our immune system as well as rejuvenate and restore our body.

5. Dock
Dock contains vitamin C and vitamin A. Besides promoting a strong immune system and dissolving heavy metal that accumulated in our body, it also helps to prevent muscular degeneration.

6. Reishi Mushroom
Reishi Mushroom contains ganoderic acids that helps to strengthen our immune system's fight against inflammation. It also helps to keep our liver in top form as well as improve the circulation of blood and increase the oxygen level in the bloodstream.

7. Yerta mate
Yerta mate has a stimulant that helps to increase the production of coritisone, the substance that helps to stimulate the function of nervous system and mind. Yerta mate also helps to strengthen our immune system's fight against allergies and forming of free radicals.

The Obesity's Weight Loss Recipes: Beet and carrot salad

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The Best Raw, Weight Loss and Healthy Recipe - Beet and carrot salad
Quoted from Raw food, volume 2, Healthy, delicious vegetarian cuisine made with living foods by Lisa Montgomery, editor, Hatherleig

By Cara Graver (the Cob studio, www.thecobstidio.com)
1 beet, scrubbed, unpeeled and grated
2 carrots, scrubbed, unpeeled and grated
Juice of one or more lemons
Combined shredded beet and carrots in a bowl and toss with juice of lemon.
Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

The Obesity' Research and Studies of Models for dietary and weight change in African-American women

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Obesity is a medical condition of excess body fat accumulated overtime, while overweight is a condition of excess body weight relatively to the height. According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered over weight, while a BMI of over 30 is an indication of obesity. According to the statistic, 68% of American population are either overweight or obese.

You can calculate your BMI index BMI= weight (kg)/ height (m2)

The Studies of Models for dietary and weight change in African-American women

In the study to explore the cultural factors that potentially influence the effectiveness of weight-control programs for African-American women and attempts to challenge the perception that such programs operate in a culture-free context, researchers showed that Evidence from clinical trials also suggests that African-American women have difficulty in losing weight. Cultural variables are thought to limit the intensity of weight-loss motivations among African-American women, but it is also possible that unrecognized cultural variables within behavioral weight-control programs limit their applicability to persons who do not fit a typical middle-class white American prototype. Many perspectives that differ between African-American and American cultures are directly relevant to the tasks and expectations involved in conventional behavioral therapy. Thus, efforts to make programs culturally appropriate for African-American women may need to go beyond superficial adaptations (eg, logistical accommodations) toward a behavioral analysis of weight control as it is likely to be approached by African-American women within their cultural context.(1)

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity 
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer


(1) "Models for dietary and weight change in African-American women: identifying cultural components" by Kumanyika SK, Morssink C, Agurs T.