Medical Advisor Journals

Saturday, July 2, 2016

Herbal therapy: Popular Herbal Lavender (Lavandula)

Lavender is a flower plant of the genus Lavandula, belonging to the family Lamiaceae, native to Asia. The herb has been used in traditional medicine to treat painful bruises and aches, to relieve various neuralgic pains, sprains, rheumatism, etc.

Health Benefits
1. 'Subsyndromal' anxiety disorder
In the investigation of orally administered Lavandula oil preparation and its effect on'subsyndromal' anxiety disorder, found that Lavandula oil preparation had a significant beneficial influence on quality and duration of sleep and improved general mental and physical health without causing any unwanted sedative or other drug specific effects. Lavandula oil preparation silexan is both efficacious and safe for the relief of anxiety disorder not otherwise specified. It has a clinically meaningful anxiolytic effect and alleviates anxiety related disturbed sleep, according to "Silexan, an orally administered Lavandula oil preparation, is effective in the treatment of 'subsyndromal' anxiety disorder: a randomized, double-blind, placebo controlled trial"by Kasper S, Gastpar M, Müller WE, Volz HP,
Möller HJ, Dienel A, Schläfke S.(1)

2. Sedative and Hypnotic Activities
In the evaluation of evaluate the sedative and hypnotic activities of the methanolic and aqueous extract of Lavandula officinalis L. on central nervous system (CNS), found that The methanolic extract produced significant sedative effect at the doses of 200, 400, and 600 mg/kg (by oral route), compared to reference substance diazepam (DZP), and an hypnotic effect at the doses of 800 and 1000 mg/kg while the treatment of mice with the aqueous extract at the doses of 200 and 400 mg/kg via oral pathway significantly reduced in both the reestablishment time and number of head dips during the traction and hole-board tests. In conclusion, these results suggest that the methanolic and aqueous extracts ofLavandula officinalis possess potent sedative and hypnotic activities, which supported its therapeutic use for insomnia, according to "Sedative and Hypnotic Activities of the Methanolic and Aqueous Extracts of Lavandula officinalisfrom Morocco" by Alnamer R, Alaoui K, Bouidida el H, Benjouad A, Cherrah Y.(2)

3. Diuretic activity
In the classification of the diuretic activity of an infusion of Lavandula officinalis in the Wistar rat found that The stability of the aldosterone concentrations in the plasma and the absence of correlation with plasma sodium concentrations, coupled with the observed clearance of the free water (0.055+/-0.007 vs. 0.045+/-0.012 mL x min(-1)) show that the increase in diuresis and the moderate increase in sodium excretion are of tubular origin. The result of the phytochemical analysis of hexane extracts in the infusion and in urine indicated that four or five chemical factors may be involved in the diuretic effect of lavender, according to "[Diuretic activity of the infusion of flowers from Lavandula officinalis].[Article in French]" by Elhajili M, Baddouri K, Elkabbaj S, Meiouat F, Settaf A.(3)

(4) Antibiofilm activity
In the examination of the antibiofilm activity of major constituents: linalool, linalyl acetate, alpha-terpineol, terpinen-4-ol of selected essential oils (EO): Lavandulaangustifblia (LEO), Melaleuca alternifolia (TTO), Melissa officinalis (MEO) found that The killing rate studies of S. aureus biofilm treated with TTO, LEO, MEO and some of their constituents revealed that partial (50%) destruction of 24-h-old biofilms (MBEC50) was achieved by the concentration 4-8 x MIC after 1 h, whereas 2-4 x MIC was enough to obtain 90% reduction in biomass metabolic activity (MBEC90) after just 4 h of treatment, according to "Antibiofilm activity of selected plant essential oils and their major components" by Budzyńska A, Wieckowska-Szakiel M, Sadowska B, Kalemba D, Rózalska B.(4)

5. Antioxidants
In the observation of total phenolics and total flavonoids for the extracts of three medicinal plants including oregano (Origanum vulgare L.), lavender (Lavandulaangustifolia) and lemon balm (Melissa officinalis) found that Origanum vulgare and Melissa officinalis extracts present the most effective antioxidant capacity in scavenging DPPH radicals, while Lavandula angustifolia is less active. High performance liquid chromatography-mass spectrometry analysis was used to identify the components of extracts. Major phenolic acids identified in the analysed species were ferulic, rosmarinic, p-coumaric and caffeic, while predominant flavonoids were quercetin, apigenin kaempherol, which were present as glucosides, according to "Antioxidant capacity and total phenolic contents of oregano (Origanum vulgare), lavender (Lavandula angustifolia) and lemon balm (Melissa officinalis) from Romania"by Spiridon I, Colceru S, Anghel N, Teaca CA, Bodirlau R, Armatu A. (5)

6. Antibacterial activity
In the identification of antibacterial activity of essential oils from 10 commonly consumed herbs: Citrus aurantium, C. limon, Lavandula angustifolia, Matricaria chamomilla, Mentha piperita, M. spicata, Ocimum basilicum, Origanum vulgare, Thymus vulgaris and Salvia officinalis found that the highest and broadest activity was shown by O. vulgare oil. Carvacrol had the highest antibacterial activity among the tested components, according to "Antibacterial effects of the essential oils of commonly consumed medicinal herbs using an in vitro model" by Soković M, Glamočlija J, Marin PD, Brkić D, van Griensven LJ.(6)

7. Antifungal activities
In the assessment of comparison of alternative to synthetic fungicides currently used in the control of devastating fungal pathogen Botrytis cinerea, from (Origanum syriacum L. var. bevanii), lavender (Lavandula stoechas L. var. stoechas) and rosemary (Rosmarinus officinalis L.), found that Essential oils of rosemary and lavender were inhibitory at relatively higher concentrations (25.6 μg/ml), according to "In vitro and in vivo antifungal activities of the essential oils of various plants against tomato grey mould disease agent Botrytis cinerea" by Soylu EM, Kurt S, Soylu S.(7)

8. Antidepressant-like effect
In the classification of the antidepressant effects of essential oils of Anthemis nobilis (chamomile), Salvia sclarea (clary sage; clary), Rosmarinus officinalis(rosemary), and Lavandula angustifolia (lavender)found that clary oil could be developed as a therapeutic agent for patients with depression and that the antidepressant-like effect of clary oil is closely associated with modulation of the DAnergic pathway, according to "Antidepressant-like effect of Salvia sclarea is explained by modulation of dopamine activities in rats" by Seol GH, Shim HS, Kim PJ, Moon HK, Lee KH, Shim I, Suh SH, Min SS.(8)

9. Acetylcholinesterase inhibitory activity
In the identification ofAcetylcholinesterase inhibitory activity of the essential oils extracted from Artemisia dracunculus L., Inula graveolens L., Lavandula officinalisChaix, and Ocimum sanctum L. found that Eugenol, in particular, was found to be a potent AChE inhibitor along with determination of the IC(50) value, a finding that has been reported for the first time in this study. However, the ratio of the contribution of the active components, including a novel AChE inhibitor, to the observed AChE inhibitory activity of the essential oils was not very high. The results of this study raise concerns about the AChE inhibitory activity of widely produced and readily accessible commercial essential oils, according to "Acetylcholinesterase inhibitory activity and chemical composition of commercial essential oils" by Dohi S, Terasaki M, Makino M.(9)

10. Obesity
In the researches of the weight control of Slim339, a proprietary fixed combination of Garcinia cambogia extract with calcium pantothenate (standardized for the content of hydroxycitric acid and pantothenic acid) and extracts of Matricaria chamomilla, Rosa damascena, Lavandula officinalis and Cananga odorata, found that During a 60-day treatment period, the average reduction in body weight for the group receiving Slim339 (n = 30) was 4.67% compared with 0.63% for the placebo group (n = 28) (p < 0.0001). Weight losses of >or=3 kg were recorded for 23 subjects in the treatment group and only one in the placebo group. It is concluded that Slim339 represents a potential , according to "Efficacy of Slim339 in reducing body weight of overweight and obese human subjects" by Toromanyan E, Aslanyan G, Amroyan E, Gabrielyan E, Panossian A.(10)

11. Cognition and mood
In the evaluation of Aromas of rosemary and lavender essential oils and theirs effect on cognition and mood found that rosemary produced a significant enhancement of performance for overall quality of memory and secondary memory factors, but also produced an impairment of speed of memory compared to controls. With regard to mood, comparisons of the change in ratings from baseline to post-test revealed that following the completion of the cognitive assessment battery, both the control and lavender groups were significantly less alert than the rosemary condition; however, the control group was significantly less content than both rosemary and lavender conditions. These findings indicate that the olfactory properties of these essential oils can produce objective effects on cognitive performance, as well as subjective effects on mood, according to "Aromas of rosemary and lavender essential oils differentially affect cognition and mood in healthy adults" by Moss M, Cook J, Wesnes K, Duckett P.(11)

Side Effects
1. The herb may cause allergic effect
2. Lavender may interact with certain medication, including antidepressants, antihistamines, pain relievers, etc,.
3. Do not use the herb in children or if you are pregnant without approval from the related field specialist.
4. Prolonged period of using the herb may cause causes breast growth in male.
5. Overdoses may cause drowsiness.
6. Etc.

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/20512042
(2) http://www.ncbi.nlm.nih.gov/pubmed/22162677
(3) http://www.ncbi.nlm.nih.gov/pubmed/12014366
(4) http://www.ncbi.nlm.nih.gov/pubmed/21630572
(5) http://www.ncbi.nlm.nih.gov/pubmed/21707233
(6) http://www.ncbi.nlm.nih.gov/pubmed/21030907
(7) http://www.ncbi.nlm.nih.gov/pubmed/20826038
(8) http://www.ncbi.nlm.nih.gov/pubmed/20441789
(9) http://www.ncbi.nlm.nih.gov/pubmed/19358605
(10) http://www.ncbi.nlm.nih.gov/pubmed/17639559
(11) http://www.ncbi.nlm.nih.gov/pubmed/12690999

Traditional Chinese Medicine Herbal Therapy - Popular Chinese Herbs - E Zhu (Rhizoma Curcuma phaeocaulis)

2. Antiplatelet aggregation and anticoagulant effects
In the investigation of the effects of Curcuma phaeocaulis Valeton on platelet aggregation and anticoagulant action in mice, indicated that Curcuma phaeocaulis Valeton can inhibit platelet aggregation, prolong time of mice coagulation and suggested that antiplatelet aggregation and anticoagulant action of processed products with vinegar is the most powerful, according to “[Studies on antiplatelet aggregation and anticoagulant action of Curcuma phaeocaulis].[Article in Chinese]” by Mao C, Xie H, Lu T.(2).

3. Cognitive effect
In the evaluation of the effects of extract of Curcuma phaeocaulis Valeton on learning and memory ability and retarding of senescence in mice, found that Valeton were significantly decreased compared with old control after starting experiment for 18 days and 24 days and for 35 days no significance difference was showed between groups. The levels of brain, liver and red blood cells lipid peroxide in the group with Curcuma phaeocaulis Valeton were considerably lower than old control, hemoglobin content was considerably increased than old control, according to “[Effects of Curcuma phaeocaulis on learning and memory and lipid peroxide in mice].[Article in Chinese]” by Li L, Han C, Cui S, Qiu D, Piao K, Xuan F.(3).

4. Anti-angiogenesis effect
In the demonstration of whether essential oil, major components of Curcuma zedoaria had anti-angiogenic effect, found that Essential oil, a fat-soluble fraction of Curcuma zedoaria, presented anti-angiogenic activity in vitro and in vivo, resulting in suppressing melanoma growth and lung metastasis. And this was associated with down-regulating MMPs, according to “Anti-angiogenesis effect of essential oil from Curcuma zedoaria in vitro and in vivo” by Chen W, Lu Y, Gao M, Wu J, Wang A, Shi R.(4).

5. Antimutagenic activity
In the investigation of the mutagenic activity of two extracts from rhizomes of Curcuma zedoaria (the mathanolic, CME, and the aqueous, CAE) and antimutagenic activity against mutagens, either 2-amino-3-methylimidazo (4,5-f) quinoline (IQ) or 4-nitroquinoline-N-oxide (4-NQO), found that the two extracts showed no mutagenicity when tested with all the tester strains either with or without the S9 mix. Moreover, the two extracts, particularly CME, presented a greater antimutagenicity than CAE did either in IQ or 4-NQO mutagens. However, the inhibition effect on lipid peroxidation was similar with both extracts. The amount of major antioxidants beta-carotene, ascorbic acid, and total polyphenols present in both CME and CAE were similar between each other. In contrast, the content of cucuminoids (44.3 mg/g extract) in CME were only found in small amounts in CAE (0.09 mg/g extract) according to “Pivotal role of curcuminoids on the antimutagenic activity of Curcuma zedoaria extracts” by Peng CH, Chiu WT, Juan CW, Mau JL, Chen CC, Peng CC, Lai EY, Chyau CC.(5).

6. Breast cancer
In this study, an extract of Curcuma phaeocaulis Valeton referred as Cpv was prepared and its anti-tumor effect was evaluated with MCF-7 and MDA-MB-231 cells, found that Cpv inhibited MCF-7 cells proliferation by inducing apoptosis mediated by increasing ROS formation, decreasing ΔΨm, regulating Bcl-2 family proteins expression, and activating caspases. Cpv treatment also modulated several signaling transduction pathways, according to “Anti-tumor potential of ethanol extract of Curcuma phaeocaulis Valeton against breast cancer cells” by Chen X, Pei L, Zhong Z, Guo J, Zhang Q, Wang Y.(6).

7. Etc.

Side Effects
1. Do not use E Zhu in case of blood, qi or spleen deficiency
2. Do not use the herb in case of excessive bleeding
3. Do not use the herb in newborn, children, or if you are pregnant or breast feeding with out consulting first with the related field specialist.
4. Etc.

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/18591805
(2) http://www.ncbi.nlm.nih.gov/pubmed/12575127
(3) http://www.ncbi.nlm.nih.gov/pubmed/12569831
(4) http://www.ncbi.nlm.nih.gov/pubmed/20920565
(5) http://www.ncbi.nlm.nih.gov/pubmed/19995306
(6) http://www.ncbi.nlm.nih.gov/pubmed/21795032

The Holistic prevention, management and treatment of Polycystic Ovarian Syndrome: TCM Herbal Medicine for Kidney Yang deficiency -Fructus Schisandrae

Polycystic Ovarian Syndrome is defined as endocrinologic diseases among reproductive-age women caused by undeveloped follicles clumping on the ovaries that interferes with the function of the normal ovaries associated with a high risk for metabolic disorder(1) as resulting of enlarged ovaries(2), leading to hormone imbalance(excessive androgen and anti-müllerian hormone (AMH) )(1)(3)(4)(5), induced Hirsutism(6)(7), reproductive disorder(10(12)), risks of type 2 diabetes(9)(10)(11), metabolic syndrome(10)(12) and early cardiovascular disease(8)(13), acne(10)(14), endometrial cancer(18)(19),weight gain and obesity(15)(16)(17). The syndrome effects over 5% of women population or 1 in 20 women.
Unfortunately, according to studies, women with PCOs after the reproductive age, are associated to continuously increase risk of type II diabetes, with no increasingaltered glucose tolerance(20), CVD and hypertension(21).

Management and Treatment according to Traditional Chinese Medicine Perspective

While conventional medicine focus of using synthetic medication to induce ovulation and assisted artificial insemination for infertility couple, if the medicine fail, traditional Chinese medicine views polycystic ovarian syndrome in different approaches.

Polycystic ovary syndrome, according to traditional Chinese medicine is a medical condition characterized by accumulative of fluid over a prolonged period of time causes of dampness and phlegms(1247a)(1247b) build up on the ovaries due to the effects of vary differentiations, affecting not only the women’s menstrual cycle, but also ovulation and fertility(1247a)(1247b).

Depending to differentiation, most common diagnosis of polycystic ovary syndrome can be classified into

Kidney yang deficiency

Along with common symptoms mentioned above, women with PCOs diagnosed with kidney yang deficiency may also experience yang vacuity induced cold expressive syndrome, including
lumbago, cold limbs, fatigue, cold aversion, feverish sensation in chest, palms and soles(1573),
difficulty in urination, enuresis, incontinence, declining libido and edema(1574) as a result of kidneys no longer perform their function in store fluid to moister and warm the body for healthy function in the body's organs and tissues, inducing adrenal insufficient chronic lower back pain(1575)(1580), depression(1575), hypothyroidism(1579)(1575), nephritis(1578)(1575), ...(1575), leading to failure in transform damp heat expression, promoted accentuation of inflammatory development of phlegm(1583).
Kidney yang deficiency has shown to alter carbohydrate and lipid metabolisms (free fatty acids, 1-monolinoleoylglycerol, and cholesterol), gut microbiota metabolism (indole-3-propionic acid), indued anovulatory infertility( 1581) and hypertension(1582) of which related to symptoms of PCOs(1576)(1577).

Herbal medicine for kidney yang deficiency

6. Fructus Schisandrae (Wu Wei Zi)
(See stress management herbs in herbal medicine for more infomation)
[Schisandra also is known as Wu Wei Zi, a twining shrub living its life by climbing on other vegetation, belongings to the family Schisandraceae, native to Asia and North America, The warm, sweet, bitter, sour, acrid, salty herb has been used in tradional Chinese medicine as antioxidant(1218)(1219), anti stress(1220)(1221), anti microbial(1224)(1225)(1226) agent and to improve metabolism(1227)(1228), enhance central nervous system(1229)(1230)(1233), treat hypertension(1231)(1232) and hypotension during exhaustion of circulatory function(1217), coughing(1234)(12135), insomnia(1237), premenstrual syndrome (PMS)(1239), menopausal symptoms(1240), depression(1233), irritability(1233), erectile dysfunction (ED)(1238), lower cholesterol(1241) and regulate blood glucose(1233), improve memory(1222)(1223), etc.
by promoting function of lung and kidney channels(1217).

Phytochemical contituents(1217)
1. Schizandrin
2. Deoxyschisandrin
3. Gamma-schisandrin
4. Schisandrol
5. Pseudo-gamma-schisandrin
6. Schizandrate B
7. Gomisin A, B, C, F, G
8. Angeloylgomisin H
9. Tigloylgomisin H
10. Benzoylgomisin H
11. Epigomisin O
12. Malic acid
13. Citric acid
14. Tartaric acid
15. Succinic acid
16. A-pinene
17. Camphene
18. B-pinene
19. Byrcene
20. A-terpinene
21. Limonene
22. G-terpinene
23. P-cymene
24. Etc.

In chronic psychological stress male rat model, schisandra protect against stress induced complications such as carbohydrate metabolism(1227) and neurosis, psychogenic depression, astheno-depressive states, schizophrenia and alcoholism disorders(1233) and improved mental performance(1233).through its reduction of the levels of corticosterone (CORT) and glucose and protect the structure of the adrenal cortex(1227).
In physiological stress, the herbal medicine also exerted its stress-protective effect against a broad spectrum of harmful factors including heat shock, skin burn, cooling, frostbite, immobilisation, swimming under load in an atmosphere with decreased air pressure, aseptic inflammation, irradiation, and heavy metal intoxication(1233).
In oxidative stress induced damage heart(1242) tissues in animal models, schisandrin B (Sch B), a dibenzocyclooctadiene derivative isolated from the fruit of Schisandra chinensis attenuated cardiotoxicity via antioxidant and anti-inflammatory effects(1242). In oxidative stress induced liver damage, oral administration of Schisandra Lignans Extract (SLE)(1243)(1244) or triterpenoid(1245) a chemical constituent from Schisandra chinensis significantly reduced liver damage(1243)(1244)(1245) in experimental animal model, through its effects of balance of oxidation and reduction in cells(1243) or upregulating cell cycle progression(1244) and anti tumor antigen(1244), or ameliorating oxidative stress(1245).]

In metabolic syndrome, beside protecting against depression(1233), irritability(1233), high level of bad cholesterol(1241) and fluctuation of blood glucose(1233), memory lose(1222)(1223),... Schisandra also exhibited anti insulin resistance(1834)(1835), anti lipid disorder metabolism(1836) induced hypercholesterolemia(1837), anti hypertension(1838)(1839). suppressed carbohydrate disorder metabolism(1842) induced hyperglycemia(1843), obesity(1840)(1841),...... causing complications of diabetes(1844)(1845) and cardiovascular disease(1838)(1846)(1847).

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

References
(1) Adiposity and metabolic dysfunction in polycystic ovary syndrome by Sam S.(PubMed)
(2) A "kiss" before conception: triggering ovulation with kisspeptin-54 may improve IVF by Young SL.(PubMed)
(3.) Androgen hyperfunction and excessive heterosexual hair growth in women, with special attention to the polycystic ovarian syndrome by Lunde O1.(PubMed)
(4) Expression of anti-Müllerian hormone in letrozole rat model of polycystic ovary syndrome by Du DF1, Li XL, Fang F, Du MR.(PubMed)
(5) [Serum levels of anti-muller hormone in women with polycystic ovary syndrome and healthy women of reproductive age].[Article in Bulgarian] by Parahuleva N, Pehlivanov B, Orbecova M, Deneva T, Uchikova E.(PubMed)
(6) [Current opinions on the etiology and pathophysiology of hirsutism].[Article in Polish] by Krysiak R1, Kedzia A, Okopień B.(PubMed)
(7) The clinical evaluation of hirsutism by Somani N1, Harrison S, Bergfeld WF.(PubMed)
(8) Polycystic ovary syndrome and insulin: our understanding in the past, present and future by Mayer SB1, Evans WS, Nestler JE.(PubMed)
(9) Association of mean platelet volume with androgens and insulin resistance in nonobese patients with polycystic ovary syndrome by Dogan BA1, Arduc A2, Tuna MM1, Karakılıc E1, Dagdelen I1, Tutuncu Y1, Berker D1, Guler S1.(PubMed)
(10) Approach to the patient: contraception in women with polycystic ovary syndrome by Yildiz BO1.(PubMed)
(11) Polycystic ovarian syndrome (PCOS): a significant contributor to the overall burden of type 2 diabetes in women by Talbott EO1, Zborowski JV, Rager JR, Kip KE, Xu X, Orchard TJ.(PubMed)
(12) Prevalence of vitamin D deficiency in Slovak women with polycystic ovary syndrome and its relation to metabolic and reproductive abnormalities by Figurová J1, Dravecká I, Javorský M, Petríková J, Lazúrová I.(PubMed)
(13) Role of Insulin Sensitizers on Cardiovascular Risk Factors in Polycystic Ovarian Syndrome: A Meta-Analysis by Thethi TK1, Katalenich B2, Nagireddy P3, Chabbra P4, Kuhadiya N5, Fonseca V1.(PubMed)
(14) Acne in hirsute women by Lumezi BG1, Pupovci HL1, Berisha VL1, Goçi AU2, Gerqari A3.(PubMed)
(15) Obesity and polycystic ovary syndrome by Naderpoor N1, Shorakae S, Joham A, Boyle J, De Courten B, Teede HJ.(PubMed)
(16) Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan by Teede H1, Deeks A, Moran L.(PubMed)
(17) Metabolic Evidence of Diminished Lipid Oxidation in Women WithPolycystic Ovary Syndrome. by Whigham LD1, Butz DE2, Dashti H3, Tonelli M3, Johnson LK1, Cook ME2, Porter WP4, Eghbalnia HR5, Markley JL6, Lindheim SR7, Schoeller DA8, Abbott DH9, Assadi-Porter FM10.(PubMed)
(18) Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis by Barry JA1, Azizia MM1, Hardiman PJ2.(PubMed)
(19) Risk of cancer among women with polycystic ovary syndrome: a Danish cohort study by Gottschau M1, Kjaer SK2, Jensen A1, Munk C1, Mellemkjaer L3.(PubMed)
(20) Polycystic ovary syndrome: metabolic consequences and long-term management by Carmina E1.(PubMed)
(21) Arterial stiffness is increased in asymptomatic nondiabetic postmenopausal women with a polycystic ovary syndrome phenotype by Armeni E1, Stamatelopoulos K, Rizos D, Georgiopoulos G, Kazani M, Kazani A, Kolyviras A, Stellos K, Panoulis K, Alexandrou A, Creatsa M, Papamichael C, Lambrinoudaki I.(PubMed)
(1246) [Clinical study of area of Jiangsu province of polycystic ovarian syndrome correlation distribution of traditional Chinese medicine syndrome type and improper diet]. [Article in Chinese] by Feng Y, Gao YP.(PubMed)
(1247) [Preliminary study on relationship of disease-syndrome-symptom of ovulatory disorder infertility based on factor analysis]. [Article in Chinese] by Li M, Ma K, Shan, J.(PubMed)
(1247a) A Comprehensive Treatment of Polycystic Ovarian Syndrome (PCOS) byLiqin Zhao
(1834) Schisphenlignans A-E: five new dibenzocyclooctadiene lignans from Schisandra sphenanthera by Liang CQ1, Hu J, Shi YM, Shang SZ, Du X, Zhan R, Xiong WY, Zhang HB, Xiao WL, Sun HD.(PubMed)
(1835) Six new lignans from the leaves and stems of Schisandra sphenantheraby Liang CQ1, Hu J, Luo RH, Shi YM, Shang SZ, Gao ZH, Wang RR, Zheng YT, Xiong WY, Zhang HB, Xiao WL, Sun HD.(PubMed)
(1936) Dietary pulp from Fructus Schisandra Chinensis supplementation reduces serum/hepatic lipid and hepatic glucose levels in mice fed a normal or high cholesterol/bile salt diet by Sun N, Pan SY1, Zhang Y, Wang XY, Zhu PL, Chu ZS, Yu ZL, Zhou SF, Ko KM.(PubMed)
(1937) Dietary Fructus Schisandrae extracts and fenofibrate regulate the serum/hepatic lipid-profile in normal and hypercholesterolemic mice, with attention to hepatotoxicity by Pan SY1, Yu Q, Zhang Y, Wang XY, Sun N, Yu ZL, Ko KM.(PubMed)
(1838) Cardioprotective effects of aqueous Schizandra chinensis fruit extract on ovariectomized and balloon-induced carotid artery injury rat models: effects on serum lipid profiles and blood pressure. Kim EY1, Baek IH, Rhyu MR.(PubMed)
(1839) Therapeutic potential of Schisandra chinensis extracts for treatment of hypertension. Introduction to: 'antihypertensive effect of gomisin A from Schisandra chinensis on angiotensin II-induced hypertension via preservation of nitric oxide bioavailability' by Park et al. Alexander JS1, Wang Y.(PubMed)
(1840) Fatty acid synthase inhibitory activity of dibenzocyclooctadiene lignans isolated from Schisandra chinensis by Na M1, Hung TM, Oh WK, Min BS, Lee SH, Bae K.(PubMed)
(1841) The high throughput screening of neuropeptide FF2 receptor ligands from Korean herbal plant extracts by Do EU1, Piao LZ, Choi G, Choi YB, Kang TM, Shin J, Chang YJ, Nam HY, Kim HJ, Kim SI.(PubMed)
(1842) [Effects of fructus schisandrae on the function of the pituitary-testis axis and carbohydrate metabolism in rats undergoing experimental navigation and high-intensity exercise]. [Article in Chinese] by Xia P1, Sun LJ, Wang J.(PubMed)
(1843) The beneficial effects of combined grape pomace and omija fruit extracts on hyperglycemia, adiposity and hepatic steatosis in db/db mice: a comparison with major index compounds by Cho SJ1, Park HJ1, Jung UJ2, Kim HJ3, Moon BS4, Choi MS5.(PubMed)
(1844)Antidiabetic Effect of Schisandrae Chinensis Fructus Involves Inhibition of the Sodium Glucose Cotransporter by Qu Y1, Chan JY, Wong CW, Cheng L, Xu C, Leung AW, Lau CB.(PubMed)
(1845) Advanced glycation end-products inhibitors isolated from Schisandra grandiflora by Poornima B1, Anand Kumar D, Siva B, Venkanna A, Vadaparthi PR, Kumar K, Tiwari AK, Suresh Babu K.(PubMed)
(1846) The protective effects of Schisandra chinensis fruit extract and its lignans against cardiovascular disease: a review of the molecular mechanisms by Chun JN1, Cho M2, So I3, Jeon JH4.(PubMed)
(1847) Beneficial effects of schisandrin B on the cardiac function in mice model of myocardial infarction by Chen P1, Pang S, Yang N, Meng H, Liu J, Zhou N, Zhang M, Xu Z, Gao W, Chen B, Tao Z, Wang L, Yang Z.(PubMed)

The Obesity's Weight Loss Recipes - Cauliflower Salad

The Obesity' Research and Studies of Atkins and other low-carbohydrate diets

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Obesity is a medical condition of excess body fat accumulated overtime, while overweight is a condition of excess body weight relatively to the height. According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered over weight, while a BMI of over 30 is an indication of obesity. According to the statistic, 68% of American population are either overweight or obese.

You can calculate your BMI index BMI= weight (kg)/ height (m2)

The Studies of Atkins and other low-carbohydrate diets

A systematic review of low-carbohydrate diets found that the weight loss achieved is associated with the duration of the diet and restriction of energy intake, but not with restriction of carbohydrates. Two groups have reported longer-term randomised studies that compared instruction in the low-carbohydrate diet with a low-fat calorie-reduced diet in obese patients (N Engl J Med 2003; 348: 2082-90; Ann Intern Med 2004; 140: 778-85). Both trials showed better weight loss on the low-carbohydrate diet after 6 months, but no difference after 12 months. The apparent paradox that ad-libitum intake of high-fat foods produces weight lossmight be due to severe restriction of carbohydrate depleting glycogen stores, leading to excretion of bound water, the ketogenic nature of the diet being appetite suppressing, the high protein-content being highly satiating and reducing spontaneous food intake, or limited food choices leading to decreased energy intake. Long-term studies are needed to measure changes in nutritional status and body composition during the low-carbohydrate diet, and to assess fasting and postprandial cardiovascular risk factors and adverse effects. Without that information, low-carbohydrate diets cannot be recommended(1).

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

(1) "Atkins and other low-carbohydrate diets: hoax or an effective tool for weight loss?" by Astrup A, Meinert Larsen T, Harper A.

General Health: Depression - The Preventive Diet

The Preventive Diet

1. Fish
Our western diet contain high amounts of omega 6 and not enough omega 3 fatty acid. The imbalance of these 2 types of omega fatty acids may lead to memory loss, mood swing and depression. Cold water fish contain high amounts of omega 3 fatty acid that not only help to restore the hormone imbalance, but also decrease the arteries clotting up by bad cholesterol and triglycerides resulting in more oxygen being transported to the brain.

2. Spinach
Spinach contains high amounts of iron that not only help to boost the production of red blood cells and increase the blood circulation but also help in preventing and treating memory loss, tiredness and trouble concentrating as well as depression.

3. Dark green leaf juiceWeakened immune system may cause concentration, memory problem, trigger anxiety and acerbate the symptoms of depression. Dark green leaf juice contains high amounts of vitamin C, that help to strengthen our immune system and prevent the forming of free radicals and inflammation.

4. Peanut
Peanut contains high amounts of folate. Study shows that people with the symptoms of depression have low levels of folate, one of the members of B vitamins.

5. Cereal
Cereal contains high amounts of niacin that help to maintain normal function and neural function. Deficiency of niacin causes memory loss, low mood, tiredness, and inactivity as well as other symptoms of depression.

6. Fresh raw vegetable
Fresh raw vegetable contains high amounts of amino acids and they are vital to the formation of antibodies to combat bacteria and viruses and are part of the enzyme and hormonal system. Deficiency of amino acids cause hormone imbalance, tiredness and poor concentration.

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

Anti Aging: The Research and Studies of Skin Aging - The Effects of Vitamins - D

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
All right reserved. Reproduction and Translation to other languages of this publication are prohibited without consent of the writer.

Who doesn't want to look 5, 10,15 or 20 years younger in comparison to people with the same age group?

The dream of finding the ingredients in rejuvenated aging skin has been ongoing since human civilization. Unfortunately, many ingredients with no commercial values have been discarded due to their effects in dampening the profits of all cosmetic companies.

Don't ask me about commercial anti-aging products. Most of them are produced for making profits and do not perform as theirs' claims. Truly, if one found to be effective, it will constitute to shelf-removal of many others with the same intention. Unfortunately, walking through the cosmetic section of health stores and super markets, thousands of these products are still packed on the shelves. How effective they are? You know the answer.

Skin aging is one of most visible process which occurs constantly in our skin organ. According to the Clinical Centre of Nis, certain plant extracts may have the ability to scavenge free radicals, to protect the skin matrix through the inhibition of enzymatic degradation, or to promote collagen synthesis in the skin, affect skin elasticity and tightness(a). Other suggested that free radicals induced domino effects in production of reactive oxygen species, can react with DNA, proteins, and fatty acids, causing oxidative damage and impairment of antioxidant system, leading injuries damage regulation pathways of skin, including wrinkles, roughness, appearance of fine lines, lack of elasticity, and de- or hyperpigmentation marks(b).
Vitamin D is a fat-soluble secosteroids found in small amount in few foods, including salmon, mackerel, sardines and tuna. The vitamin plays an important role in modulation of cellular proliferation, apoptosis induction, tumor growth suppression and promotion in absorption of minerals, including calcium, iron, magnesium, phosphate and zinc.

1. Plasma of vitamin D
Levels of 25-hydroxyvitamin D levels [25(OH)D] was associated to risk of skin aging as the study at Universitätsklinikum des Saarlandes showed. UV-radiation exerts both skin aging -promoting and -inhibiting effects on skin aging. Altered mineral homeostasis caused by a high vitamin D activity, exhibited the prematureaging that include, such as short lifespan, retarded growth, ectopic calcification, immunological deficiency, osteoporosis, atherosclerosis, hypogonadism, skin and general organ atrophy but in laboratory investigations, vitamin D compounds protects the skin against the hazardous effects of various skin aging-inducing agents, including ultraviolet (UV) radiation(1). Therefore optimal serum concentration are necessary due to its U-shaped risk(2). The Stanford University School of Medicine study indicated that vitamin D deficiency enhanced low scores for specific photodamage parameters including erythema/telangiectasias, hyperpigmentation, and wrinkling(3), specially, the skin from aging subjects can decrease by greater than twofold the capacity of the skin to produce previtamin D3(4).

2. The effects
According to Treviglio-Caravaggio Hospital, daily supplementation of vitamin D indicated is about 800-1,000 IU/day but may increase up to a maximum dose of 2,000 IU/day in conditions of severe vitamin D deficiency with a concomitant reduced or no sun exposure, reduced dietary intake and reduced calcium absorption(5)(6). Some researchers suggested that intrinsic skin aging may reflects the reduction processes that are common in internal organs, as the reduced production of sex hormones influence skin morphology and functions, skinpermeability, wound healing, sebaceous lipogenesis, and the metabolism of skincells in both sex and Vitamin D administered and antioxidant treatment may be beneficial(7). In postmenopausal health, low levels of vitamin D may induce obesity, malabsorption syndromes, medication use (e.g. anticonvulsants, antiretrovirals), skin aging. According to Universidad de Zaragoza, Increased level of the vitamin D through regular sunlight exposure (without sunscreens) for 15 min, 3-4 times a week, in the middle of the day in summer may be beneficial, but supplementation intake of vitamin D2 (ergocalciferol) or vitamin D3 (cholecalciferol) should be monitored depending on the dose used and the presence of concomitant medical conditions such as renal disease(8). Dr Johnson MA at the University of Georgia, insisted " Diminished synthesis of vitamin D in the skin that occurs with aging and poor dietary intake contribute to the high prevalence of poor vitamin D status in older adults"(9). Cutaneous vitamin D3 synthesis declines with age, it would require input of an additional 2600 iu/d (65 microg/d) of oral vitamin D3 to ensure that 97.5% of older women have 25(OH)D values at or above desirable levels (10).

Taken altogether, optimal serum concentration was found to interact in enhancing production of sex hormones and reducing photodamage parameters including erythema/telangiectasias, hyperpigmentation, and wrinkling due to aging. As always, all articles written by Kyle J. Norton are for information & education only, please consult your Doctor & Related field specialist before applying

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

References
(1) Unravelling of hidden secrets: The role of vitamin D in skin aging by Reichrath J.(PubMed)
(2) Vitamin D and aging by Tuohimaa P.(PubMed)
(3) Association of facial skin aging and vitamin D levels in middle-aged white women by Chang AL1, Fu T, Amir O, Tang JY.(PubMed)
(4) Aging decreases the capacity of human skin to produce vitamin D3 by MacLaughlin J, Holick MF.(PubMed)
(5) Vitamin D: role and opportunity to prescribe by Resmini G1, Tarantino U, Iolascon G.(PubMed)
(6) Vitamin D and aging by Gallagher JC.(PubMed)
(7) Hormonal therapy of intrinsic aging by Zouboulis CC1, Makrantonaki E.(PubMed)
(8) EMAS position statement: Vitamin D and postmenopausal health by Pérez-López FR1, Brincat M, Erel CT, Tremollieres F, Gambacciani M, Lambrinoudaki I, Moen MH, Schenck-Gustafsson K, Vujovic S, Rozenberg S, Rees M(PubMed)
(9) Nutrition and aging--practical advice for healthy eating by Johnson MA(PubMed)
(10) Barriers to optimizing vitamin D3 intake for the elderly by Heaney RP.(PubMed)

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer