Medical Advisor Journals

Thursday, July 7, 2016

Phytochemicals in Foods - The Effects of Perillyl alcohol

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Perillyl alcohol

Perillyl alcohol is a phytochemicals in the class of Monoterpenes, found abundantly in citrus oils, caraway, mints, etc.

Health Benefits
1. Breast cancer
In the searching the effective way in treating breast cancer by investigating the activity of a combination of perillyl alcohol (POH), methyl jasmonate (MJ) with cisplatin, found that Combination treatment of POH and MJ blocked cells at the G0/G1 phase of the cell cycle and the addition of cisplatin forced the cells to progress through the cell cycle and induced apoptosis. Apoptotic mechanistic studies indicated that POH and MJ treatment activated tumor necrosis factor receptor 1 and this was further increased by the addition of cisplatin. It was also found that mitochondrial membrane potential decreased with POH and MJ treatment; this effect was further enhanced by cisplatin treatment, according to "Perillyl alcohol and methyl jasmonate sensitize cancer cells to cisplatin" byYeruva L, Hall C, Elegbede JA, Carper SW.(1)

2. Pancreatic cancer
In the development of enhanced single or combinatorial therapies to decrease the pathogenesis of this invariably fatal disease. Melanoma differentiation-associated gene-7/interleukin-24 (mda-7/IL-24) is a potent cancer gene therapeutic because of its broad-spectrum cancer-specific apoptosis-inducing properties as well as its multipronged indirect antitumor activities,
found that a dietary agent perillyl alcohol (POH) in combination with Ad.mda-7 efficiently reverses the mda-7/IL-24 "protein translational block" by inducing reactive oxygen species, thereby resulting in mda-7/IL-24 protein production, growth suppression, and apoptosis. Pharmacologic inhibitor and small interfering RNA studies identify xanthine oxidase as a major source of superoxide radical production causing these toxic effects, according to " Mechanism of in vitro pancreatic cancer cell growth inhibition by melanoma differentiation-associated gene-7/interleukin-24 and perillyl alcohol" by Lebedeva IV, Su ZZ, Vozhilla N, Chatman L, Sarkar D, Dent P, Athar M, Fisher PB.(2)

3. Skin cancer
in the evaluation of preparation and characterization ofa novel poly-lactic glycolic acid (PLGA)-based microparticle formulation of perillyl alcohol (POH) and its efficacy against di-methyl benzo anthracene-induced skin papilloma in Swiss albino mice, found that in vitro efficacy of POH-bearing PLGA microparticles was evaluated by examining their differential cytotoxicity and assessing their ability to inhibit epidermoid carcinoma cell line (A253). The POH-based microparticles when administered to tumor-bearing animals caused greater tumor regression and increased survival rate (∼80%) as compared with the group receiving free form of POH (survival rate 40%), according to "Anticancer efficacy of perillyl alcohol-bearing PLGA microparticles" by Farazuddin M, Sharma B, Khan AA, Joshi B, Owais M.(3)

4. Lipid Membranes
In the assessment of the possible biophysical effects of these compounds on membranes quantitatively, the influence of limonene and its bio-oxidation products on a membrane model composed of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) using differential scanning calorimetry (DSC), isothermal titration calorimetry (ITC), and electron paramagnetic resonance spectroscopy (EPR), found that limonene (1), perillyl alcohol (2), and perillaldehyde (3) partitioned into the DMPC membrane, whereas perillic acid (4) did not. The DSC results demonstrated that all the partitioning compounds strongly perturbed the phase transition of DMPC, whereas no perturbation of the local membrane order was detected by EPR spectroscopy, according to "Influence of the Active Compounds of Perilla frutescens Leaves on Lipid Membranes" by Duelund L, Amiot A, Fillon A, Mouritsen OG.(4)

5. Antioxidant and antiproliferative effects
In the investigation of antioxidant potential of three monoterpenoids (carvone,perillyl alcohol, and α-terpineol), using two methods: DPPH and ORAC and the antiproliferative effect of these monoterpenoids against nine cancerous cell lines performed and compared to limonene and doxorubicin, found that all samples tested had very low antioxidant activity in the DPPH assay, but α-terpineol (2.72μmolTrolox equiv./μmol) could be compared to commercial antioxidants in the ORAC assay. The antiproliferative results obtained encourage future in vivo studies for α-terpineol, since this monoterpenoid presented cytostatic effect against six cell lines, especially for breast adenocarcinoma and chronic myeloid leukemia, in a range of 181-588μM, according to "Evaluation of the antioxidant and antiproliferative potential of bioflavors" by Bicas JL, Neri-Numa IA, Ruiz AL, De Carvalho JE, Pastore GM.(5)

6. Transplant coronary artery disease TCAD prevention
In the study of whether systematical dissection of the prenylation pathway to better define the mechanism behind statin inhibition in chronic allograft rejection in heart transplants, or transplant coronary artery disease (TCAD), found that FPT and GGPT-2 (inhibition) are the key enzymes in the HGM-CoA reductase pathway and most influential in TCAD prevention. TCAD reduction is most closely related to smooth muscle cell migration, but not its anti-inflammatory properties, according to "Prevention of transplant coronary artery disease by prenylation inhibitors" by Stein W, Schrepfer S, Itoh S, Kimura N, Velotta J, Palmer O, Bartos J, Wang X, Robbins RC, Fischbein MP.(6)

7. Oxidative stress
In the investigation of the protective effects of perillyl alcohol (POH) on ethanol-induced acute liver injury in Wistar rats and its probable mechanism, ethanol administration decreased hepatic reduced glutathione content and various antioxidant enzymes activity. TNF-α production and NFκ-B activation was also found to be increased after ethanol administration. POH pre-treatment significantly ameliorates ethanol induced acute liver injury possibly by inhibition of lipid peroxidation, replenishment of endogenous enzymatic and non-enzymatic defense system, downregulation of TNF-α as well as NFκ-B, according to "Perillyl alcoholprotects against ethanol induced acute liver injury in Wistar rats by inhibiting oxidative stress, NFκ-B activation and proinflammatory cytokine production" by Khan AQ, Nafees S, Sultana S.(7)

8. Non small cell lung cancer
In the investigation of the effects of perillyl alcohol (POH) and its metabolite perillic acid (PA) on the proliferation of non small cell lung cancer (NSCLC, A549, and H520) cells, found that exposing the cells to an IC50 concentration of POH or PA sensitized the cells to cisplatin and radiation in a dose-dependent manner. These results indicate that POH and PA in combination therapy may have chemotherapeutic value against NSCLC, according to "Perillyl alcohol and perillic acid induced cell cycle arrest and apoptosis in non small cell lung cancer cells" by Yeruva L, Pierre KJ, Elegbede A, Wang RC, Carper SW.(8)

9. Etc.

Most Common Diseases of 50 Plus: Disease of CNS - Alzheimer's Disease(AD)(The Article) - The Causes

The Causes

1. Toxic chemicals in our environment
Accumulation of aluminum and mercury deposits usually present in the area of the affected brain and our body can assimilate high amounts of aluminum without knowing it.

2. Testosterone deficiency
As men age, the pituitary gland produces less testosterone and more free testosterone is converted to estrogen caused by the sex hormone binding globulin and the increasing of by-product prolactin of testosterone stimulating the production of the enzyme 5-alpha reductase that causes the conversion of testosterone to gihydro-testosterones DHT resulting in low levels of testosterone.

3. Alcohol abuse
Alcohol not only increases the heart palpitation and high blood pressure but also damaging of the liver that is vital for toxin cleansing. If the liver can not perform it's function, that causes free radicals building up in all organs in our body including our brain.

4. Poor diet
North Americans consume 30 % more fat than any other people in the world. Our brain requires fat to function better but over supplement of fat causes cholesterol build-up and high blood pressure resulting in poor blood circulation as well asdamaging of arterial wall.

5. Obesity
Obesity increase the abdominal fat that not causes the forming of aromatase enzyme resulting in aromatasing testosterone into estrogen but increase the building up of cholesterol in the brain blood vessels, without enough oxygen brain cells die off.

6. Diabetes
High concentration of glucose causes the blood thickening resulting in poor circulation of blood, depleting oxygen levels that is vital to brain cells needs.

7. Vitamin and minerals deficiency
Our body needs all kind of vitamins and minerals to perform it's function everyday. Any deficiency not only causes a weakened immune system but also other kinds of disease as well as faciliate the eventual onset of Alzheimer's disease.

8. Hear disease
Heart disease weakens the function of the heart resulting in less blood flow to the brain region causing depletion of oxygen that is vital for brain cells to function properly.

9. High levels of cholesterol
Clogged brain vessels can not provide enough oxygen to its cells needs.

10. Smoking
Smoking not only causes the depletion of oxygen levels but calcium build up in the arterial wall resulting in damaging of brain cells.

Women Health: Menstrual Disorder -Dysmenorrhea - Treatments in Herbal Medicine Perspective

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Dysmenorrhea

Dysmenorrhea (painful menstruation) is defined as a condition of severe uterine pain during menstruation. Some women may experience periodic pains during or prior to, or after menstrual periods in the lower abdomen as resulting of over production of certain hormones in the prostaglandins family. In traditional Chinese medicine, dysmenorrhea is defined as a pain in the lower abdomen, appearing with menstrual cycle that can spread over to the whole abdomen and lumbosacral region, depending to diagnosis.

Types of dysmenorrhea
1. Primary dysmenorrhea
Primary dysmenorrhea is defined as no underlying cause for menstrual cramps or difficult menstruation occurring just before or during menstruation. It occurs about 90% in the girls in the first 2 years of menstruation. Some researchers suggested that it may be caused immature of the reproductive organs.

2. Secondary dysmenorrhea
Secondary dysmenorrhea is caused by gynecological diseases. including hormone imbalance, endometriosis, fibromas, pelvic inflammatory disease, etc.

The Treatments

B. In Herbal Medicine Perspective
1. Ginger
Ginger is most commonly used in western medicine in treating dysmenorrhea for a long period of time due to its stimulated function of anti- inflammation, spasmolytic, and circulation. Ginger helps to inhibit cyclo-oxygenase and lipoxygenase enzymes that cause menstrual cramps.

2. Herbal tea
Herbal tea contains high amounts of phytochemicals that helps to relax stomach and uterus muscles resulting in reduced or no menstrual cramps. Drinking herbal tea until the cramping subsides is recommended.

3. Cramp Bark
Cramp bark is a a uterine tonic. It is used to relieve cramps and spasm of all kinds, to treat uterine and ovarian pain, dysmenorrhea as well as relaxing uterine muscle.

4. Raspberry leaf
Raspberry leaf has been used in traditional herbal therapy for a variety of conditions relating to the female reproductive tract, especially during pregnancy and to facilitate delivery. It is a uterine tonic that helps to relax the uterine muscles resulting in reduced menstrual cramps.

5. Pennyroyal
Pennyroyal is a relaxant and stimulant. It has the same property of relaxing the uterine muscle like raspberry leaf, and has been used for treating menstrual cramps.

6. Mugwort
Mugwort has been used in Chinese medicine to relieve pain by promoting blood circulation, restoring depressed liver by invigorating the flow of qi , regulating menstruation and alleviating pain as well as irregular menstruation and dysmenorrhea.

7. Cinnamon
Cinnamon is a highly antioxidant and anti-inflammation herb enhancing inhibition of the metabolism of prostaglandins, intake of cinnamon tea will help to reduce menstrual cramps. Overdose of cinnamon is toxic to your kidney and liver.

8. Etc.

Pregnancy Miracle
Reverse Infertility And Get Pregnant Naturally
Using Holistic Ancient Chinese Medicine
Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

The Best Weight Loss and Healthy Recipe - Date syrup (India)

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The Best Weight Loss and Healthy Recipe - Date syrup (India)
Contribited by Ani's Raw Food Asia by Ani Phyo, Published by Life Long Book. Asian Cuisine the Raw Food Way. You can visit her website at aniphyo.com

Make 1 cup
It is simple to make date syrup. All you need are your favorite dates and a blender. I choose soft or semi soft dates, like Khadrawy or Medjool. If using a drier date, use the water in the recipe to soak the dates first until soft, about 30 minutes or longer.

1/2 cup pitted dates
1/2 to 1 cup of filtered water as desired
Place pitted dates and water in blender, blend smooth. Add as much water as you like for desired consistency.
Variation: for different flavors of dates syrup try the following
1. use an arrange (whole, seeded and peeled) instead of water and add additional water only as needed
2. Substitute filtered water for Rose water
3. Add 1 tbsp. cacao or carob powder, the seeds of a vanilla bean or 1 tsp. vanilla extract.
4. Add lavender or mint extracts, to taste.

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

The Obesity' Research and Studies of Effects of the DASH diet alone and in combination with exercise and weight loss on blood pressure and cardiovascular biomarkers

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Obesity is a medical condition of excess body fat accumulated overtime, while overweight is a condition of excess body weight relatively to the height. According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered over weight, while a BMI of over 30 is an indication of obesity. According to the statistic, 68% of American population are either overweight or obese.

You can calculate your BMI index BMI= weight (kg)/ height (m2)

The Studies of the DASH diet alone and in combination with exercise and weight loss on blood pressure and cardiovascular biomarkers

In the study to compare the DASH diet alone or combined with a weightmanagement program with usual diet controls among participants with prehypertension or stage 1 hypertension (systolic BP, 130-159 mm Hg; or diastolic BP, 85-99 mm Hg), showed that For overweight or obese persons with above-normal BP, the addition of exercise and weight loss to the DASH diet resulted in even larger BP reductions, greater improvements in vascular and autonomic function, and reduced left ventricular mass(1).

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

(1) "Effects of the DASH diet alone and in combination with exercise and weightloss on blood pressure and cardiovascular biomarkers in men and women with high blood pressure: the ENCORE study" by Blumenthal JA, Babyak MA, Hinderliter A, Watkins LL, Craighead L, Lin PH, Caccia C, Johnson J, Waugh R, Sherwood A.

Most Common Diseases of 50plus: Thyroid disease: Hypothyroidism – The Risk factors

Hypothyroidism

Hypothyroidism is a condition in which the thyroid gland is under active and produces very little thyroid hormones.

The Risk factors

1. Genetic and environmental factors and family history
Genetic and environmental factors are involved in the pathogenesis of autoimmune thyroid disease (AITD). Family members of patients with AITD are at increased risk for AITD, but not all will develop overt hypothyroidism or hyperthyroidism, according to the study by the Academic Medical Center, Netherlands(11).

2. Smoking
smoking is a powerful risk factor for thyroid disease, especially in populations with a high smoking frequency, according to the study by the Aarhus University Hospital(12). Other study indicated that smoking reduced the risk of hypothyroidism and increased the risk of hyperthyroidism(13).

3. Age
Hypothyroidism is associated to increased age. In the study to evaluate the ability of the aged rat pituitary to increase TSH secretion in response to major decreases in serum thyroid hormones, hypothyroidism was induced by methimazole in young and old, male and female, Dutch-Miranda and Wistar rats, showed that the ability of the pituitary thyrotrophs to increase hormonal secretion in response to decreased levels of thyroid hormones is impaired in the old rat, even when the thyroid hormone levels are dramatically reduced(14).

4. Autoimmune disorders, thyroid injury, post partum state, non-thyroidal illness, or medications
According to the study by the Universitätsspital Basel, in the study of Hypothyroidism suggested that search for hypothyroidism should therefore focus on patients with symptoms and signs and/or those presenting risk factors for development of hypothyroidism (e.g., autoimmune disorders, thyroid injury, post partum state). Because of the lack of specificity of sings and symptoms of this frequent disorder the diagnosis is based on measurement of TSH or TSH and fT4 in case of conditions that may affect TSH values such as non-thyroidal illness, or medications(15).

5. Radiation
In the study to investigate the possible histopathological effects of pulse modulated Radiofrequency (RF) fields on the thyroid gland using light microscopy, electron microscopy and immunohistochemical methods, indicated that whole body exposure to pulse-modulated RF radiation that is similar to that emitted by global system for mobile communications (GSM) mobile phones can cause pathological changes in the thyroid gland by altering the gland structure and enhancing caspase-dependent pathways of apoptosis(16).

6. Post preganacy
In the study of the spontaneous occurrence of, and recovery from primary hypothyroidism were observed after delivery in 6 women with autoimmune thyroiditis, showed that diffuse goiter was noticed 1-3 months after delivery. The blood thyroid hormone level was found to be lowest at 3-6 months post-partum, with a thyroxine iodine value of 1.0 +/- 0.6 mug/dl (mean +/- SD) (normal 3.0-7.2), triiodithyronine value of 77 +/- 11 ng/dl (normal 90-190) and T3 resin sponge uptake of 21 +/- 2.8% (normal 24-37)(17).

7. Partial thyroidectomy
is associated to increased risk of hypothyroidism, but according to study of one hundred and twenty-two patients reviewed 1-7 years after partial thyroidectomy for thyrotoxicosis by two surgeons who had left thyroid remnants of different size, there was no significant difference in the prevalence of hypothyroidism or in the serum levels of thyroxine, tri-iodothyronine or thyroid-stimulating hormone between the two groups of patients. The overall prevalence of hypothyroidism was 16 per cent(18).

Most Common Diseases of 50plus: Thyroid disease: Hypothyroidism – The Symptoms

Hypothyroidism

Hypothyroidism is a condition in which the thyroid gland is under active and produces very little thyroid hormones.

The Symptoms

Symptoms of the Hypothyroidism is depended to the severe stage of the disease. as it progresses slowly over years. Most common symptoms include
1. Weight gain and fatigue
In a prospective observational research design where 198 consecutive breast cancer patients receiving adjuvant chemotherapy were monitored from start to end and 6 months post-therapy on changes in anthropometics, fatigue, nutritional intake, physical activity, thyroid and steroid hormones, found that a weight gain over >5 lb in 22.2% of this patient population with a significant and progressive gain of 6.7 lb (P < 0.0001) at 6 months. Ninety four percent of all patients reported fatigue and 56% of patients reported lowered physical activity. A significant reduction in serum free and total estradiol (P < 0.0001) was observed indicative of reduction in ovarian function with 86% amenorrehic at the end of treatment. A significant reduction in mean serum triiodothyronine uptake levels (P < 0.05), in addition to a significant increase in TBG (P < 0.0001) from baseline to end of chemotherapy, was observed. In addition 20-25% of this patient group was already diagnosed with clinical hypothyroidism at diagnosis and treated. Changes in fatigue frequency and serum sex-hormone-binding globulin (SHBG) were variables significantly predictive of weight gain (P < 0.0001)(1).

2. Vitiligo and alopecia areata
There is a report of the parents of an 18-year-old woman had noticed white hair while combing their daughter's hair 12 years ago. They found tiny white spots on her scalp, but she was asymptomatic. The spots have since progressed. Examination of the affected skin on the scalp was marked by the presence of a chalky/ivory white macule, 8 to 10 cm in diameter, conforming to that of segmental (zosteriformis) vitiligo (Figure 1). The lesions were located on the temporoparietal region of the scalp. The hair over the macules was white (leukotrichia) and dry, coarse, and brittle. The patient's nails were thin and dull. Her thyroid profile revealed the following: triiodothyronine, 1.12 nmol/L (0.95-2.5 nmol/L); thyroxine, 69.21 nmol/L (60.0-120.0 nmol/L); and thyroid-stimulating hormone, 6.26 microIU/mL (0.25-5.00 microIU/mL), indicative of primary hypothyroidism(2).

3. Chronic constipation
Geriatric patient educational material and a general practice review suggest insufficient dietary fiber intake, inadequate fluid intake, decrease physical activity, side effects of drugs, hypothyroidism, sex hormones and colorectal cancer obstruction may play a role in the pathogenesis of constipation, according to the study by the University of California at Los Angele(3).

4. Urticaria and puffiness of hands and feet, yellow ivory skin, coarse rough dry skin, alopecia periorbital edema, amenorrhe, dysparunia, PCO, PMS and Breast tenderness, menstrual irregularities and infertility
In the study to study is to highlight the presenting dermatologic and gynecologic manifestations of firstly-diagnosed hypothyroid females, showed that Compared to euthyroid cases, hypothyroid ones were presenting mostly with amenorrhea (OR=7.76). Other gynecologic manifestations that were prominent in hypothyroid cases were dysparunia, PCO, PMS and Breast tenderness. On the other hand, rate of menstrual irregularities and infertility were non-significantly different in both groups.hypothyroid women showed also significantly higher frequency of urticaria and puffiness of hands and feet (both were present in 16.7% in hypothyroid vs. 3.3% of euthyroid cases, p =0.007, OR=5.8). Hypothyroid cases showed also significantly higher frequency of yellow ivory skin (OR=5.4) and coarse rough dry skin (OR=3.8). On the other hand, alopecia and periorbital edema were observed only among cases of hypothyroidsm and none of euthyroid cases(4).

5. Depression
In the study to investigate the depression-like behavior performances of subclinical hypothyroidism (SCH) rat. SCH rat model induced by hemi-thyroid electrocauterization, and the behavior performances were measured by sucrose preference test, force swimming test (FST), and tail suspension test (TST). SCH rat model was established successfully by hemi-thyroid electrocauterization, found that SCH could result in depression-like behavior, accompanied with subtle hyperactivity of HPA axis. The reduced hippocampal T3 prior to the reduction of thyroid hormone in serum might be taken as an early sign of hippocampus impairment in the progression from SCH to CH(5).

6. Mood, declarative memory, motor learning and working memory
In a double-blinded, randomized, cross-over study of usual dose l-T(4) (euthyroid arm) vs. higher dose l-T(4) (subclinical thyrotoxicosis arm) in hypothyroid subjects, showed that The Profile of Mood States (POMS) confusion, depression, and tension subscales were improved during the subclinical thyrotoxicosis arm. Motor learning was better during the subclinical thyrotoxicosis arm, whereas declarative and working memory measures did not change. This improvement was related to changes in the SF-36 physical component summary and POMS tension subscales and free T(3) levels(6).

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Sources
(a) http://www.ncbi.nlm.nih.gov/pubmed/17933284
(1) http://www.ncbi.nlm.nih.gov/pubmed/14997046
(2) http://www.ncbi.nlm.nih.gov/pubmed/21675503
(3) http://www.ncbi.nlm.nih.gov/pubmed/17219073
(4) http://www.ncbi.nlm.nih.gov/pubmed/21475555
(5) http://www.ncbi.nlm.nih.gov/pubmed/23794115
(6) http://www.ncbi.nlm.nih.gov/pubmed/18285414