Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Obesity is a medical condition of excess body fat accumulated overtime, while overweight is a condition of excess body weight relatively to the height. According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered over weight, while a BMI of over 30 is an indication of obesity. According to the statistic, 68% of American population are either overweight or obese.
You can calculate your BMI index BMI= weight (kg)/ height (m2)
The Studies of Intake of sugar-sweetened beverages and weight gain
Consumption of sugar-sweetened beverages (SSBs), particularly carbonated soft drinks, may be a key contributor to the epidemic of overweight and obesity, by virtue of these beverages' high added sugar conten. Researchers at the , Harvard School of Public Health, showed that a school-based intervention found significantly less soft-drink consumption and prevalence of obese and overweight children in the intervention group than in control subjects after 12 mo, and a recent 25-week randomized controlled trial in adolescents found further evidence linking SSB intake to body weight. The weight of epidemiologic and experimental evidence indicates that a greater consumption of SSBs is associated with weightgain and obesity. Although more research is needed, sufficient evidence exists for public health strategies to discourage consumption of sugary drinks as part of ahealthy lifestyle(1).
Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
(1) " Intake of sugar-sweetened beverages and weight gain: a systematic review" by Malik VS, Schulze MB, Hu FB.
Monday, July 18, 2016
Most Common Diseases of 50plus: Thyroid disease: Thyroid adenoma Prevention - The Phytochemicals
Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Thyroid disease
Thyroid disease is defined as a condition of malfunction of thyroid. Hyperthyroidism is a condition in which the thyroid gland is over active and produces too much thyroid hormones.
Thyroid adenoma
Thyroid adenoma is a benign tumor started in the layer of cell lined the inner surface of the thyroid gland. The disease are relatively common among adults living in the United States. According to the study by the Mayo Clinic and Mayo Foundation, there is a report of 4 patients described in whom a follicular carcinoma developed following thyroidectomy for a benign follicular neoplasm. Most thyroid nodules are Thyroid adenoma.
Phytochemicals to prevent thyroid adenoma
1. Epigallocatechin-3-gallate (EGCG)
According to the study by the Health and Nutrition Sciences, University of Calabria, EGCG (10, 40, 60 μM) treatment inhibited the growth of FB-2 and WRO cells in a dose-dependent manner. These changes were associated with reduced cyclin D1, increased p21 and p53 expression. Furthermore, EGCG suppressed phosphorylation of AKT and ERK1/2. In addition EGCG treatment results in reduction of cell motility and migration. Changes in motility and migration in FB-2 were associated with modulation in the expression of several proteins involved in cell adhesion and reorganization of actin cytoskeleton. After 24 h EGCG caused an increase of the E-cadherin expression and a concomitant decrease of SNAIL, ZEB and the basic helix-loop-helix transcription factor TWIST. Besides expression of Vimentin, N-cadherin and α5-integrin was down-regulated(31). Other study indicated that EGCG treatment inhibited the growth of ARO cells in a dose-dependent manner. Furthermore, EGCG suppressed phosphorylation of EGFR, ERK1/2, JNK, and p38. These changes were associated with increased p21 and reduced cyclin B1/CDK1 expression. In addition, EGCG treatment increased the accumulation of sub-G1 cell, activated caspase-3 and cleaved PARP(32).
2. Isoflavone derivatives
Antiproliferative effect of cD-tBoc on these cells is mediated through ERβ. Furthermore, cD-tBoc potently increased apoptosis and cell necrosis. Co-incubation with the antiapoptotic agent Z-VAD-FMK reversed the growth inhibitory effect elicited by cD-tBoc. These results support the hypothesis that estrogens are involved in the proliferation of MTC. The potent anti-proliferative effects mediated by isoflavone derivatives in the human MTC cell line TT suggest and that this property may be utilized to design effective anti-neoplastic agents, according to study by the Tel-Aviv University(33).
3. Phytoestrogens
Epidemiological and pathological data suggest that thyroid cancer may well be an estrogen-dependent disease. In the study of the relationship between thyroid cancer risk and dietary phytoestrogens, which can have both estrogenic and antiestrogenic properties, using the present data from a multiethnic population-based case-control study of thyroid cancer conducted in the San Francisco Bay Area. Of 817 cases diagnosed between 1995 and 1998 (1992 and 1998 for Asian women), 608 (74%). Of 793 controls identified through random-digit dialing, 558 (70%) indicated that phytoestrogen consumption was assessed via a food-frequency questionnaire and a newly developed nutrient database. The consumption of traditional and nontraditional soy-based foods and alfalfa sprouts were associated with reduced risk of thyroid cancer. Consumption of “western” foods with added soy flour or soy protein did not affect risk. Of the seven specific phytoestrogenic compounds examined, the isoflavones, daidzein and genistein [odds ratio (OR), 0.70; 95% confidence interval (CI), 0.44-1.1; and OR, 0.65, 95% CI, 0.41-1.0, for the highest versus lowest quintile of daidzein and genistein, respectively] and the lignan, secoisolariciresinol (OR, 0.56; 95% CI, 0.35-0.89, for the highest versus lowest quintile) were most strongly associated with risk reduction. Findings were similar for white and Asian women and for pre- and postmenopausal women. Our findings suggest that thyroid cancer prevention via dietary modification of soy and/or phytoestrogen intake in other forms may be possible but warrants further research at this time(34).
Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Sources
(32) http://www.ncbi.nlm.nih.gov/pubmed/21725973
(33) http://www.ncbi.nlm.nih.gov/pubmed/22776298
(34) http://www.ncbi.nlm.nih.gov/pubmed/11815400
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Thyroid disease
Thyroid disease is defined as a condition of malfunction of thyroid. Hyperthyroidism is a condition in which the thyroid gland is over active and produces too much thyroid hormones.
Thyroid adenoma
Thyroid adenoma is a benign tumor started in the layer of cell lined the inner surface of the thyroid gland. The disease are relatively common among adults living in the United States. According to the study by the Mayo Clinic and Mayo Foundation, there is a report of 4 patients described in whom a follicular carcinoma developed following thyroidectomy for a benign follicular neoplasm. Most thyroid nodules are Thyroid adenoma.
The Prevention
Phytochemicals to prevent thyroid adenoma
1. Epigallocatechin-3-gallate (EGCG)
According to the study by the Health and Nutrition Sciences, University of Calabria, EGCG (10, 40, 60 μM) treatment inhibited the growth of FB-2 and WRO cells in a dose-dependent manner. These changes were associated with reduced cyclin D1, increased p21 and p53 expression. Furthermore, EGCG suppressed phosphorylation of AKT and ERK1/2. In addition EGCG treatment results in reduction of cell motility and migration. Changes in motility and migration in FB-2 were associated with modulation in the expression of several proteins involved in cell adhesion and reorganization of actin cytoskeleton. After 24 h EGCG caused an increase of the E-cadherin expression and a concomitant decrease of SNAIL, ZEB and the basic helix-loop-helix transcription factor TWIST. Besides expression of Vimentin, N-cadherin and α5-integrin was down-regulated(31). Other study indicated that EGCG treatment inhibited the growth of ARO cells in a dose-dependent manner. Furthermore, EGCG suppressed phosphorylation of EGFR, ERK1/2, JNK, and p38. These changes were associated with increased p21 and reduced cyclin B1/CDK1 expression. In addition, EGCG treatment increased the accumulation of sub-G1 cell, activated caspase-3 and cleaved PARP(32).
2. Isoflavone derivatives
Antiproliferative effect of cD-tBoc on these cells is mediated through ERβ. Furthermore, cD-tBoc potently increased apoptosis and cell necrosis. Co-incubation with the antiapoptotic agent Z-VAD-FMK reversed the growth inhibitory effect elicited by cD-tBoc. These results support the hypothesis that estrogens are involved in the proliferation of MTC. The potent anti-proliferative effects mediated by isoflavone derivatives in the human MTC cell line TT suggest and that this property may be utilized to design effective anti-neoplastic agents, according to study by the Tel-Aviv University(33).
3. Phytoestrogens
Epidemiological and pathological data suggest that thyroid cancer may well be an estrogen-dependent disease. In the study of the relationship between thyroid cancer risk and dietary phytoestrogens, which can have both estrogenic and antiestrogenic properties, using the present data from a multiethnic population-based case-control study of thyroid cancer conducted in the San Francisco Bay Area. Of 817 cases diagnosed between 1995 and 1998 (1992 and 1998 for Asian women), 608 (74%). Of 793 controls identified through random-digit dialing, 558 (70%) indicated that phytoestrogen consumption was assessed via a food-frequency questionnaire and a newly developed nutrient database. The consumption of traditional and nontraditional soy-based foods and alfalfa sprouts were associated with reduced risk of thyroid cancer. Consumption of “western” foods with added soy flour or soy protein did not affect risk. Of the seven specific phytoestrogenic compounds examined, the isoflavones, daidzein and genistein [odds ratio (OR), 0.70; 95% confidence interval (CI), 0.44-1.1; and OR, 0.65, 95% CI, 0.41-1.0, for the highest versus lowest quintile of daidzein and genistein, respectively] and the lignan, secoisolariciresinol (OR, 0.56; 95% CI, 0.35-0.89, for the highest versus lowest quintile) were most strongly associated with risk reduction. Findings were similar for white and Asian women and for pre- and postmenopausal women. Our findings suggest that thyroid cancer prevention via dietary modification of soy and/or phytoestrogen intake in other forms may be possible but warrants further research at this time(34).
Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Sources
(32) http://www.ncbi.nlm.nih.gov/pubmed/21725973
(33) http://www.ncbi.nlm.nih.gov/pubmed/22776298
(34) http://www.ncbi.nlm.nih.gov/pubmed/11815400
Women Health: Menstrual Disorder - Dysmenorrhea - Traditional Chinese Herbal Medicine Treatment for Imbalance Of Liver in Dysmenorrhea
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Dysmenorrhea
Dysmenorrhea (painful menstruation) is defined as a condition of severe uterine pain during menstruation. Some women may experience periodic pains during or prior to, or after menstrual periods in the lower abdomen as resulting of over production of certain hormones in the prostaglandins family. In traditional Chinese medicine, dysmenorrhea is defined as a pain in the lower abdomen, appearing with menstrual cycle that can spread over to the whole abdomen and lumbosacral region, depending to diagnosis.
Girls in South East Asia have learnt in their early women life from grand mother wisdom, that they do not engage in any activity that distorts their regular period. Menstruation disorders should be treated immediately, otherwise, it may cause wide range of women diseases, such as infertility, according to traditional Chinese medicine.
Treatment for Imbalance Of Liver in Dysmenorrhea
Liver imbalance is either caused by yin or yang deficiency that interferes with liver function in blood formation and storing and qi circulation.
1. Angelica (Dong quai)
Angelica is a queen herb for women reproductive tonic, it has been used in traditional Chinese medicine in treating all women productive disorder, including
a) Increasing the liver in blood formation
b) Reducing liver blood stagnation caused over production of certain hormones
c) Releasing the qi stagnation including pre menstrual syndrome.
d) Phytoestrogen
The plant types weak estrogen helps to occupy the estrogen receptor sites, thus improving the liver function in regulating the prostaglandins hormones resulting in lessening the menstrual cramps and pain.
2. Milk thistle seed
Milk thistle seed is a liver tonic herb, besides helping to to restore the qi stagnation caused by environment toxins, it also improves the liver function in blood and qi function by regenerating the liver's cell.
3. White pony ( bai shao)
White pony is a blood tonic herbs, besides helping to improve the liver function in blood formation, thus reducing the menstrual cramps and pain caused blood deficiency,it also promotes liver yin and yang balancing by calming liver yang and preserving yin.
4. Fennel seed ( xiao hu xiang)
Fennel seed besides help to release the stagnation caused by imbalance of yin yang qi in the liver, it also helps to improve the function of abdominal organ resulting in lessoning the symptoms of menstrual cramps and pain.
5. Yellow dock root
Yellow dock root is a liver tonic medicine, besides hepling to detoxify liver by removing any harmful substances accumulated in the liver, it improves the liver function in regulating the production of hormones before and after ovulation.
Pregnancy Miracle
Reverse Infertility And Get Pregnant Naturally
Using Holistic Ancient Chinese Medicine
Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Dysmenorrhea
Dysmenorrhea (painful menstruation) is defined as a condition of severe uterine pain during menstruation. Some women may experience periodic pains during or prior to, or after menstrual periods in the lower abdomen as resulting of over production of certain hormones in the prostaglandins family. In traditional Chinese medicine, dysmenorrhea is defined as a pain in the lower abdomen, appearing with menstrual cycle that can spread over to the whole abdomen and lumbosacral region, depending to diagnosis.
Girls in South East Asia have learnt in their early women life from grand mother wisdom, that they do not engage in any activity that distorts their regular period. Menstruation disorders should be treated immediately, otherwise, it may cause wide range of women diseases, such as infertility, according to traditional Chinese medicine.
Treatment for Imbalance Of Liver in Dysmenorrhea
Liver imbalance is either caused by yin or yang deficiency that interferes with liver function in blood formation and storing and qi circulation.
1. Angelica (Dong quai)
Angelica is a queen herb for women reproductive tonic, it has been used in traditional Chinese medicine in treating all women productive disorder, including
a) Increasing the liver in blood formation
b) Reducing liver blood stagnation caused over production of certain hormones
c) Releasing the qi stagnation including pre menstrual syndrome.
d) Phytoestrogen
The plant types weak estrogen helps to occupy the estrogen receptor sites, thus improving the liver function in regulating the prostaglandins hormones resulting in lessening the menstrual cramps and pain.
2. Milk thistle seed
Milk thistle seed is a liver tonic herb, besides helping to to restore the qi stagnation caused by environment toxins, it also improves the liver function in blood and qi function by regenerating the liver's cell.
3. White pony ( bai shao)
White pony is a blood tonic herbs, besides helping to improve the liver function in blood formation, thus reducing the menstrual cramps and pain caused blood deficiency,it also promotes liver yin and yang balancing by calming liver yang and preserving yin.
4. Fennel seed ( xiao hu xiang)
Fennel seed besides help to release the stagnation caused by imbalance of yin yang qi in the liver, it also helps to improve the function of abdominal organ resulting in lessoning the symptoms of menstrual cramps and pain.
5. Yellow dock root
Yellow dock root is a liver tonic medicine, besides hepling to detoxify liver by removing any harmful substances accumulated in the liver, it improves the liver function in regulating the production of hormones before and after ovulation.
Pregnancy Miracle
Reverse Infertility And Get Pregnant Naturally
Using Holistic Ancient Chinese Medicine
Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
The Best Weight Loss and Healthy Recipe - Tuna and white bean
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
The Best Weight Loss and Healthy Recipe - Tuna and white bean
The Lunch Box recipes , Packed with fun, healthy meals that keep them smiling, by Kate McMillan and Sarah Putman Clegg, published by Weldonowen.
Stealth side salad: Chunky salad perfect for youngsters who have never to let a shred of lettuce pass their lips
In a small container with tight-fitting lid, combine 2 tablespoons olive oil, 1 teaspoon lemon juice and 1é2 teaspoon Dijon mustard. Add equal parts canned white beans, rinsed abd grained and canned tuna, drained and flaked. Sprinkle with minced celery and onion. Cover and shake to combine. Season with salt and pepper.
Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
The Best Weight Loss and Healthy Recipe - Tuna and white bean
The Lunch Box recipes , Packed with fun, healthy meals that keep them smiling, by Kate McMillan and Sarah Putman Clegg, published by Weldonowen.
Stealth side salad: Chunky salad perfect for youngsters who have never to let a shred of lettuce pass their lips
In a small container with tight-fitting lid, combine 2 tablespoons olive oil, 1 teaspoon lemon juice and 1é2 teaspoon Dijon mustard. Add equal parts canned white beans, rinsed abd grained and canned tuna, drained and flaked. Sprinkle with minced celery and onion. Cover and shake to combine. Season with salt and pepper.
Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Herbal therapy: Popular Herbal Mullein (Verbascum thapsus)
Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Herbal Mullein (Verbascum thapsus)
Mullein is hairy biennial plant, genus Verbascum, belonging toScrophulariaceae, native to Europe, northern Africa and Asia. The herb has been used in traditional medicine over thousands of year as analgesic, antihistaminic, anti-inflammatory, anticancer, antioxidant, antiviral, bacteristat, cardio-depressant, estrogenic, sedative medicine and to treat cough, whooping cough, tuberculosis, bronchitis, hoarseness, pneumonia, earaches, colds, chills, flu, etc.
Health benefits
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Herbal Mullein (Verbascum thapsus)
Mullein is hairy biennial plant, genus Verbascum, belonging toScrophulariaceae, native to Europe, northern Africa and Asia. The herb has been used in traditional medicine over thousands of year as analgesic, antihistaminic, anti-inflammatory, anticancer, antioxidant, antiviral, bacteristat, cardio-depressant, estrogenic, sedative medicine and to treat cough, whooping cough, tuberculosis, bronchitis, hoarseness, pneumonia, earaches, colds, chills, flu, etc.
Health benefits
1. Antiviral and mode effects
In the investigation of the methanolic extract of Verbascum thapsus and its antiviral activity against the pseudorabies virus strain RC/79 (PrV) found that When cells were pre-treated with the extract prior to virus infection, the inhibition in plaque formation was 70%. PrV was highly inhibited when it was incubated with plant extract or when the extract was added during the adsorption phase (99%), according to "Antiviral effect and mode of action of methanolic extract ofVerbascum thapsus L. on pseudorabies virus (strain RC/79)" by Escobar FM, Sabini MC, Zanon SM, Tonn CE, Sabini LI.(1)
2. Genotoxic and cytotoxic activities
In the evaluation of the methanolic extract of V. thapsus at doses of 100, 300 and 500 mg/kg and theirs genotoxic and cytotoxic activities effects found that the extracts did not produce a significant increase in the frequency of MNPCE in bone marrow and neither altered the relationship PCE/NCE respect to negative control. These cytogenotoxic findings contribute the preclinical knowledge of methanolic extract of V. thapsus and provide security in its use as herbal medicine, according to "Genotoxic evaluation of a methanolic extract of Verbascum thapsus using micronucleus test in mouse bone marrow" by Escobar FM, Sabini MC, Zanon SM, Cariddi LN, Tonn CE, Sabini LI.(2)
3. Antiangiogenic and antiproliferative activities
In the evaluation of the activity of one new iridoid compound named verbathasin A, along with ten known compounds in Verbascum thapsus, and theirs Antiangiogenic and antiproliferative activities, found that All the isolates except 10-deoxyeucommiol and ajugol were tested for antiangiogenic and antiproliferative activities, and compounds luteolin and 3-O-fucopyranosylsaikogenin F showed promising antiproliferative activities, with an obvious effect of inducing apoptosis of A549 lung cancer cells, according to "Isolation of chemical constituents from the aerial parts of Verbascum thapsus and their antiangiogenic and antiproliferative activities" by Zhao YL, Wang SF, Li Y, He QX, Liu KC, Yang YP, Li XL.(3)
4. Antiinflammatory effects
In the evaluation of Verbascum thapsus commonly known as 'mullein' is part of a large family of Scrophulariaceae consisting of more than 360 species and theirs anti inflammatory effects
found that a significant decrease of the expression and activity of iNOS, extracellular O(2) (-) production, SOD, CAT and GPx activity when the cells were treated with verbascoside. Based on these results it is hypothesized that verbascoside has antiinflammatory properties since it reduces the production of superoxide radicals and consequently reduces the activity of iNOS, according to "Antiinflammatory effects in THP-1 cells treated with verbascoside" by
Speranza L, Franceschelli S, Pesce M, Reale M, Menghini L, Vinciguerra I, De Lutiis MA, Felaco M, Grilli A.(4)
5. Anti-hepatoma activity
In the evaluation of Fifteen crude extracts from fifteen natural medicines from Canada, including Verbascum thapsus L. (Scrophulariaceae) found that The samples were examined by in vitro evaluation for their cytotoxicity. The results showed that the effects of crude drugs on hepatitis B virus genome-containing cell lines were different from those against non hepatitis B virus genome-containing cell lines. C. groenlandica was observed to be the most effective against the growth of all five cell lines and its chemotherapeutic values will be of interest for further studies, according to "In vitro anti-hepatoma activity of fifteen natural medicines from Canada" by Lin LT, Liu LT, Chiang LC, Lin CC (5)
6. Anaesthetic ear drops
In the comparison of the efficacy and tolerance of Otikon Otic Solution (Healthy-On Ltd, Petach-Tikva, Israel), a naturopathic herbal extract (containing Allium sativum, Verbascum thapsus, Calendula flores, and Hypericum perforatum in olive oil) and Anaesthetic (Vitamed Pharmaceutical Ltd, Benyamina, Israel) ear drops (containing ametocaine and phenazone in glycerin) in the management of ear pain associated with acute otitis media (AOM) found that Otikon, an ear drop formulation of naturopathic origin, is as effective as Anaesthetic ear drops and was proven appropriate for the management of AOM-associated ear pain, according to "Efficacy of naturopathic extracts in the management of ear pain associated with acute otitis media" by Sarrell EM, Mandelberg A, Cohen HA.(6)
7. Mycobacteria
In the investigation of Common mullein weed (Verbascum thapsus) and its effect on Mycobacteria, the notoriously tough micro-organisms found that this common weed could harbour the answer to beating one of the world's biggest infectious killers, according to"What's in a Name? Can Mullein Weed Beat TB Where Modern Drugs Are Failing" by McCarthy E, O'Mahony JM.(7)
8. Etc.
Side effects
1. Mullein may cause allergic effect to some people such as tightness in your chest, skin hives. rash, itchy, etc.
2. Do not use the herb in children or if you are pregnant or breast feeding without approval from the related field specialist.
3. Etc.
Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/21999656
(2) http://www.ncbi.nlm.nih.gov/pubmed/21834240
(3) http://www.ncbi.nlm.nih.gov/pubmed/21656353
(4) http://www.ncbi.nlm.nih.gov/pubmed/20812283
(5) http://www.ncbi.nlm.nih.gov/pubmed/12203264
(6) http://www.ncbi.nlm.nih.gov/pubmed/11434846
(7) http://www.ncbi.nlm.nih.gov/pubmed/20953419
In the investigation of the methanolic extract of Verbascum thapsus and its antiviral activity against the pseudorabies virus strain RC/79 (PrV) found that When cells were pre-treated with the extract prior to virus infection, the inhibition in plaque formation was 70%. PrV was highly inhibited when it was incubated with plant extract or when the extract was added during the adsorption phase (99%), according to "Antiviral effect and mode of action of methanolic extract ofVerbascum thapsus L. on pseudorabies virus (strain RC/79)" by Escobar FM, Sabini MC, Zanon SM, Tonn CE, Sabini LI.(1)
2. Genotoxic and cytotoxic activities
In the evaluation of the methanolic extract of V. thapsus at doses of 100, 300 and 500 mg/kg and theirs genotoxic and cytotoxic activities effects found that the extracts did not produce a significant increase in the frequency of MNPCE in bone marrow and neither altered the relationship PCE/NCE respect to negative control. These cytogenotoxic findings contribute the preclinical knowledge of methanolic extract of V. thapsus and provide security in its use as herbal medicine, according to "Genotoxic evaluation of a methanolic extract of Verbascum thapsus using micronucleus test in mouse bone marrow" by Escobar FM, Sabini MC, Zanon SM, Cariddi LN, Tonn CE, Sabini LI.(2)
3. Antiangiogenic and antiproliferative activities
In the evaluation of the activity of one new iridoid compound named verbathasin A, along with ten known compounds in Verbascum thapsus, and theirs Antiangiogenic and antiproliferative activities, found that All the isolates except 10-deoxyeucommiol and ajugol were tested for antiangiogenic and antiproliferative activities, and compounds luteolin and 3-O-fucopyranosylsaikogenin F showed promising antiproliferative activities, with an obvious effect of inducing apoptosis of A549 lung cancer cells, according to "Isolation of chemical constituents from the aerial parts of Verbascum thapsus and their antiangiogenic and antiproliferative activities" by Zhao YL, Wang SF, Li Y, He QX, Liu KC, Yang YP, Li XL.(3)
4. Antiinflammatory effects
In the evaluation of Verbascum thapsus commonly known as 'mullein' is part of a large family of Scrophulariaceae consisting of more than 360 species and theirs anti inflammatory effects
found that a significant decrease of the expression and activity of iNOS, extracellular O(2) (-) production, SOD, CAT and GPx activity when the cells were treated with verbascoside. Based on these results it is hypothesized that verbascoside has antiinflammatory properties since it reduces the production of superoxide radicals and consequently reduces the activity of iNOS, according to "Antiinflammatory effects in THP-1 cells treated with verbascoside" by
Speranza L, Franceschelli S, Pesce M, Reale M, Menghini L, Vinciguerra I, De Lutiis MA, Felaco M, Grilli A.(4)
5. Anti-hepatoma activity
In the evaluation of Fifteen crude extracts from fifteen natural medicines from Canada, including Verbascum thapsus L. (Scrophulariaceae) found that The samples were examined by in vitro evaluation for their cytotoxicity. The results showed that the effects of crude drugs on hepatitis B virus genome-containing cell lines were different from those against non hepatitis B virus genome-containing cell lines. C. groenlandica was observed to be the most effective against the growth of all five cell lines and its chemotherapeutic values will be of interest for further studies, according to "In vitro anti-hepatoma activity of fifteen natural medicines from Canada" by Lin LT, Liu LT, Chiang LC, Lin CC (5)
6. Anaesthetic ear drops
In the comparison of the efficacy and tolerance of Otikon Otic Solution (Healthy-On Ltd, Petach-Tikva, Israel), a naturopathic herbal extract (containing Allium sativum, Verbascum thapsus, Calendula flores, and Hypericum perforatum in olive oil) and Anaesthetic (Vitamed Pharmaceutical Ltd, Benyamina, Israel) ear drops (containing ametocaine and phenazone in glycerin) in the management of ear pain associated with acute otitis media (AOM) found that Otikon, an ear drop formulation of naturopathic origin, is as effective as Anaesthetic ear drops and was proven appropriate for the management of AOM-associated ear pain, according to "Efficacy of naturopathic extracts in the management of ear pain associated with acute otitis media" by Sarrell EM, Mandelberg A, Cohen HA.(6)
7. Mycobacteria
In the investigation of Common mullein weed (Verbascum thapsus) and its effect on Mycobacteria, the notoriously tough micro-organisms found that this common weed could harbour the answer to beating one of the world's biggest infectious killers, according to"What's in a Name? Can Mullein Weed Beat TB Where Modern Drugs Are Failing" by McCarthy E, O'Mahony JM.(7)
8. Etc.
Side effects
1. Mullein may cause allergic effect to some people such as tightness in your chest, skin hives. rash, itchy, etc.
2. Do not use the herb in children or if you are pregnant or breast feeding without approval from the related field specialist.
3. Etc.
Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/21999656
(2) http://www.ncbi.nlm.nih.gov/pubmed/21834240
(3) http://www.ncbi.nlm.nih.gov/pubmed/21656353
(4) http://www.ncbi.nlm.nih.gov/pubmed/20812283
(5) http://www.ncbi.nlm.nih.gov/pubmed/12203264
(6) http://www.ncbi.nlm.nih.gov/pubmed/11434846
(7) http://www.ncbi.nlm.nih.gov/pubmed/20953419
The Holistic prevention, management and treatment of Polycystic Ovarian Syndrome: TCM Herbal Medicine for Spleen Yang deficiency - Cordyceps militaris
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Polycystic Ovarian Syndrome
Polycystic Ovarian Syndrome is defined as endocrinologic diseases among reproductive-age women caused by undeveloped follicles clumping on the ovaries that interferes with the function of the normal ovaries associated with a high risk for metabolic disorder(1) as resulting of enlarged ovaries(2), leading to hormone imbalance(excessive androgen and anti-müllerian hormone (AMH) )(1)(3)(4)(5), induced Hirsutism(6)(7), reproductive disorder(10(12)), risks of type 2 diabetes(9)(10)(11), metabolic syndrome(10)(12) and early cardiovascular disease(8)(13), acne(10)(14), endometrial cancer(18)(19),weight gain and obesity(15)(16)(17). The syndrome effects over 5% of women population or 1 in 20 women.
Unfortunately, according to studies, women with PCOs after the reproductive age, are associated to continuously increase risk of type II diabetes, with no increasingaltered glucose tolerance(20), CVD and hypertension(21).
Management and Treatment according to Traditional Chinese Medicine Perspective
While conventional medicine focus of using synthetic medication to induce ovulation and assisted artificial insemination for infertility couple, if the medicine fail, traditional Chinese medicine views polycystic ovarian syndrome in different approaches.
Polycystic ovary syndrome, according to traditional Chinese medicine is a medical condition characterized by accumulative of fluid over a prolonged period of time causes of dampness and phlegms(1247a)(1247b) build up on the ovaries due to the effects of vary differentiations, affecting not only the women’s menstrual cycle, but also ovulation and fertility(1247a)(1247b).
Depending to differentiation, most common diagnosis of polycystic ovary syndrome can be classified into
Spleen yang deficiency
Spleen yang deficiency is a serve form of spleen qi deficiency, characterized by a condition of inability of spleen in distribution of fluid and nutrient to the body organs, in removal and descend the turbids(2072), causing malfunctions functions of the organs and fluid retention. Prolong period of spleen yang deficiency may induce the development of phlegm, including women with PCOs.
Women with PCOs diagnosed by spleen yang deficiency may also experience yang vacuity impelled cold expression of additional symptoms of abdominal pain(2074), lack of appetite(2076), fatigue(2075), lightheadedness(2075) and headache(2075), weakness of the four limbs(2077), diarrhea(2073)(2076), chilliness(2077), edema(2074), pale, swollen, wet tongue(2076) and weak, slow, deep pulse(2072),....
In the review of the Data base provided by PubMed, spleen qi deficiency may alter certain metabolic pathways, such as the energy, protein, and glycolytic metabolisms(2078), body weight and motor behavior(2079), skeletal muscle function(3080), blood glucose, lipid metabolism and fat-islet axie.(2081),.....
Herbal Medicine recommended for Treatment of PCOs induced by spleen yang deficiency
2. Cordyceps militaris(Dong Chong Xia cao)
Dong chong xia cao, the sweet and warm herb also known as cordyceps sinensis, used in traditional Chinese medicine as immune enhancer(2229)(2230), anti microbial(2231)(2232), anti oxidant(2233)(2234), anti inflammatory(2235)(2236), anti cancer(2237)(2238), cardio-protective(2239)(2240)(2241) agent and for treatment of cirrhosis(2242)(2243), lower back pain (due to it analgesic property)(2244), chronic cough and asthma(2245)(2246), ... as it tonifies yang, nourishes lung yin, transforms phlegm, by enhancing the function of kidney and lung channels(2229).
Phytochemical constituents(2228)
1. Cordyceps polysaccharide
2. Ergosterol
3. Cordycepic acid
4. Amino Acids
5. Lysine
6. Aspartic acid
7. Threonine
8. Taurine
9. Etc.
On metabolic syndrome, in diabetics rat model, Dong chong xia cao inhibited significantly the level of glucose metabolic disorders(2250)(such as hyperglycemia(2251)(2252) by enhancing the glyconeogenesis in serum glucose and lipid profiles(2247), by promoting anti-lipid peroxidation activities and inhibit accumulation of cholesteryl ester in macrophages via suppression of LDL oxidation(2253), regulating the expression of lipoprotein lipase (LPL) and hepatic lipase (HL) activity(2253) and activating protein kinase (AMPK)(2254), improved insulin sensitive(2248)(2249) by inhibiting the activity of human protein tyrosine phosphatase 1B (PTP1B) activity(2249) though metabolism of glucose and lipid(2247)(2248), the microcirculation disturbance(2247)(2248) and the oxidative stress(2247)
On obesity, dong chong xia cao has found to improve the obesity(2255)(2256) through decreased body weight and improved energy uptake(2255) by inhibiting alpha-glycosidase(2255) and adipogenic(2256) and lipid accumulation(2256) activity.
On metabolic syndrome's complications, the herbal medicine reduced risk of diabetes(2259)(2260) and cardiovascular disease(2259) through inhibition of low grade inflammation(2259)(2260) and platelet activation(2263)via immunomodulatory(2259)(2260) and antioxidant activity(2261)(2262).
According to Jenteh Junior College of Medicine and Nursing Management and National Cheng Kung University Medical College, dong chong xia cao improved sex desire(2257), and fertility(2258) through increasing serum testosterone and estradiol-17 (E2) concentrations in production of quality of maturing oocyte, respectively without effecting follicle stimulating hormone (FSH), luteinizing hormone (LH) or prolactin(2257).
Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
References
(1) Adiposity and metabolic dysfunction in polycystic ovary syndrome by Sam S.(PubMed)
(2) A "kiss" before conception: triggering ovulation with kisspeptin-54 may improve IVF by Young SL.(PubMed)
(3.) Androgen hyperfunction and excessive heterosexual hair growth in women, with special attention to the polycystic ovarian syndrome by Lunde O1.(PubMed)
(4) Expression of anti-Müllerian hormone in letrozole rat model of polycystic ovary syndrome by Du DF1, Li XL, Fang F, Du MR.(PubMed)
(5) [Serum levels of anti-muller hormone in women with polycystic ovary syndrome and healthy women of reproductive age].[Article in Bulgarian] by Parahuleva N, Pehlivanov B, Orbecova M, Deneva T, Uchikova E.(PubMed)
(6) [Current opinions on the etiology and pathophysiology of hirsutism].[Article in Polish] by Krysiak R1, Kedzia A, Okopień B.(PubMed)
(7) The clinical evaluation of hirsutism by Somani N1, Harrison S, Bergfeld WF.(PubMed)
(8) Polycystic ovary syndrome and insulin: our understanding in the past, present and future by Mayer SB1, Evans WS, Nestler JE.(PubMed)
(9) Association of mean platelet volume with androgens and insulin resistance in nonobese patients with polycystic ovary syndrome by Dogan BA1, Arduc A2, Tuna MM1, Karakılıc E1, Dagdelen I1, Tutuncu Y1, Berker D1, Guler S1.(PubMed)
(10) Approach to the patient: contraception in women with polycystic ovary syndrome by Yildiz BO1.(PubMed)
(11) Polycystic ovarian syndrome (PCOS): a significant contributor to the overall burden of type 2 diabetes in women by Talbott EO1, Zborowski JV, Rager JR, Kip KE, Xu X, Orchard TJ.(PubMed)
(12) Prevalence of vitamin D deficiency in Slovak women with polycystic ovary syndrome and its relation to metabolic and reproductive abnormalities by Figurová J1, Dravecká I, Javorský M, Petríková J, Lazúrová I.(PubMed)
(13) Role of Insulin Sensitizers on Cardiovascular Risk Factors in Polycystic Ovarian Syndrome: A Meta-Analysis by Thethi TK1, Katalenich B2, Nagireddy P3, Chabbra P4, Kuhadiya N5, Fonseca V1.(PubMed)
(14) Acne in hirsute women by Lumezi BG1, Pupovci HL1, Berisha VL1, Goçi AU2, Gerqari A3.(PubMed)
(15) Obesity and polycystic ovary syndrome by Naderpoor N1, Shorakae S, Joham A, Boyle J, De Courten B, Teede HJ.(PubMed)
(16) Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan by Teede H1, Deeks A, Moran L.(PubMed)
(17) Metabolic Evidence of Diminished Lipid Oxidation in Women WithPolycystic Ovary Syndrome. by Whigham LD1, Butz DE2, Dashti H3, Tonelli M3, Johnson LK1, Cook ME2, Porter WP4, Eghbalnia HR5, Markley JL6, Lindheim SR7, Schoeller DA8, Abbott DH9, Assadi-Porter FM10.(PubMed)
(18) Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis by Barry JA1, Azizia MM1, Hardiman PJ2.(PubMed)
(19) Risk of cancer among women with polycystic ovary syndrome: a Danish cohort study by Gottschau M1, Kjaer SK2, Jensen A1, Munk C1, Mellemkjaer L3.(PubMed)
(20) Polycystic ovary syndrome: metabolic consequences and long-term management by Carmina E1.(PubMed)
(21) Arterial stiffness is increased in asymptomatic nondiabetic postmenopausal women with a polycystic ovary syndrome phenotype by Armeni E1, Stamatelopoulos K, Rizos D, Georgiopoulos G, Kazani M, Kazani A, Kolyviras A, Stellos K, Panoulis K, Alexandrou A, Creatsa M, Papamichael C, Lambrinoudaki I.(PubMed)
(1246) [Clinical study of area of Jiangsu province of polycystic ovarian syndrome correlation distribution of traditional Chinese medicine syndrome type and improper diet]. [Article in Chinese] by Feng Y, Gao YP.(PubMed)
(1247) [Preliminary study on relationship of disease-syndrome-symptom of ovulatory disorder infertility based on factor analysis]. [Article in Chinese] by Li M, Ma K, Shan, J.(PubMed)
(1247a) A Comprehensive Treatment of Polycystic Ovarian Syndrome (PCOS) bny by Liqin Zhao
(2072) Spleen, Earth
(2073) [Research on building method of spleen kidney Yang deficiency diarrhea rats model]. [Article in Chinese] by Pan X, Hu CJ, Geng YY, Zhao L, Wu WH, Wu XQ, Zhong ZD.(PubMed)
(2074) Treatment of an elderly patient with acute abdominal pain with traditional Korean medicine by Son CG1.(PubMed)
(2075) Shenzhu Tiaopi granule combined with lifestyle intervention therapy for impaired glucose tolerance: a randomized controlled trial by Fang Z1, Zhao J2, Shi G3, Shu Y3, Ni Y3, Wang H3, Ding L3, Lu R3, Li J3, Zhu X3, Cheng S4, Zhang X3, Liu Y5, Wang J6, Luo Y3, Fan Q3, Guo C3, Jiang T3, Wu Q3, Fan L3, Ling H3, Cui L3, Luo Y3, Yang H3, Anderson RM7.(PubMed)
(2075) Direct moxibustion to treat spleen qi and yang deficiency fatigue: a pilot study by Thorne TL1, Hanes DA2, Wild H3, Colbert A4.(PubMed)
(2076) [Clinical observation on fuzhong (supporting the middle-jiao) manipulation of tuina for infantile anorexia]. [Article in Chinese] by Wang YY, Liu XY.(PubMed)
(2077) [Effect of umbilicus moxibustion therapy on physical conditions of yang-deficiency volunteers]. [Article in Chinese] by Zhang YY1.(PubMed)
(2078) Analysis of the restorative effect of Bu-zhong-yi-qi-tang in the spleen-qi deficiency rat model using (1)H-NMR-based metabonomics by Zheng XF1, Tian JS2, Liu P3, Xing J1, Qin XM1.(PubMed)
(2079) [1H NMR based metabolomics study of bu-zhong-yi-qi-tang in the spleen-qi deficiency rat model]. [Article in Chinese] by Chen L, Xiang H, Xing J, Tian JS, Qin XM, Du GH.(PubMed)
(2080) Bufei Jianpi granules improve skeletal muscle and mitochondrial dysfunction in rats with chronic obstructive pulmonary disease by Dong Y1,2, Li Y3,4,5, Sun Y6, Mao J7, Yao F8, Tian Y9, Wang L10, Li L11, Li S12,13,14, Li J15,16,17(PubMed)
(2081) [Clinical observation on obesity and hyperlipidemia of liver qi stagnation and spleen deficiency pattern in female patients treated with combined therapy of acupuncture and tapping method]. [Article in Chinese] by Wu B, Liu ZC, Xu B.(PubMed)
(2228) Dong chong xia cao(Complementary and Alternative Healing University)
(2229) [Effect of cordyceps sinensis on cellular immunity in rats with chronic renal insufficiency]. [Article in Chinese] by Cheng Q1.(PubMed)
(2230) Comparisons on enhancing the immunity of fresh and dry Cordyceps militaris in vivo and in vitro by Zhu SJ1, Pan J, Zhao B, Liang J, Ze-Yu W, Yang JJ.(PubMed)
(2231) Phytochemical and antimicrobial activities of Himalayan Cordyceps sinensis (Berk.) by Sacc. Mamta, Mehrotra S, Amitabh, Kirar V, Vats P, Nandi SP, Negi PS, Misra K.(PubMed)
(2232) Hot-water extract from mycelia of Cordyceps sinensis as a substitute for antibiotic growth promoters by Koh JH1, Suh HJ, Ahn TS.(PubMed)
(2233) Antioxidant activity of the extracts from fruiting bodies of cultured Cordyceps sinensis by Yamaguchi Y1, Kagota S, Nakamura K, Shinozuka K, Kunitomo M.(PubMed)
(2234) Anti-oxidation activity of different types of natural Cordyceps sinensis and cultured Cordyceps mycelia by Li SP1, Li P, Dong TT, Tsim KW.(PubMed)
(2235) Anti-inflammatory principles from Cordyceps sinensis by Yang ML1, Kuo PC, Hwang TL, Wu TS.(PubMed)
(2236) Evaluation of the anti-inflammatory and anti-proliferation tumoral cells activities of Antrodia camphorata, Cordyceps sinensis, and Cinnamomum osmophloeum bark extracts by Rao YK1, Fang SH, Tzeng YM.(PubMed)
(2237) Anti-tumor effect of Cordyceps militaris in HCV-infected human hepatocarcinoma 7.5 cells by Lee S1, Lee HH, Kim J, Jung J, Moon A, Jeong CS, Kang H, Cho H.(PubMed)
(2238) Toxicity evaluation of cordycepin and its delivery system for sustained in vitro anti-lung cancer activity by Aramwit P1, Porasuphatana S2, Srichana T3, Nakpheng T3.(PubMed)
(2239) [Current studies and prospect of anti-thrombotic effect of Cordyceps fungi]. [Article in Chinese] by Li XG1, Xiao JH1.(PubMed)
(2240) Protective effect of extract of Cordyceps sinensis in middle cerebral artery occlusion-induced focal cerebral ischemia in rats by Liu Z1, Li P, Zhao D, Tang H, Guo J.(PubMed)
(2241) Role of dongchongxiacao (Cordyceps) in prevention of contrast-induced nephropathy in patients with stable angina pectoris by Zhao K1, Li Y, Zhang H.(PubMed)
(2242) [Cordyceps mycelia extract decreases portal hypertension in rats with dimethylnitrosamine-induced liver cirrhosis: a study on its histological basis]. [Article in Chinese] by Wang XB1, Liu P, Tang ZP, Li FH, Liu CH, Hu YY, Xu LM.(PubMed)
(2243) [Acting mechanism of Cordyceps mycelia extract for antagonizing hepatic sinusoidal capillarization in rats with dimethylnitrosamine induced liver cirrhosis]. [Article in Chinese] by Wang XB1, Liu P, Tang ZP.(PubMed)
(2244) Anti-inflammatory and antinociceptive effects of cordymin, a peptide purified from the medicinal mushroom Cordyceps sinensis by Qian GM1, Pan GF, Guo JY.(PubMed)
(2245) Cordycepin alleviates airway hyperreactivity in a murine model of asthma by attenuating the inflammatory process by Yang X1, Li Y1, He Y1, Li T1, Wang W2, Zhang J3, Wei J4, Deng Y5, Lin R6.(PubMed)
(2246) The extract of Cordyceps sinensis inhibited airway inflammation by blocking NF-κB activity by Chiou YL1, Lin CY.(PubMed)
(2247) [Investigation of compound, compatibility of Rhodiola crenulata, Cordyceps militaris, and Rhum palmatum, on metabolic syndrome treatment VI--improving hyperglycemia-mediated renal damage]. [Article in Chinese] Fu JY1, Zhang XL2, Tian JY2, Huang LW2, Zhang PC3, Ye F2.(PubMed)
(2248) [Investigation of a compound, compatibility of Rhodiola crenulata, Cordyceps militaris, and Rhum palmatum, on metabolic syndrome treatment. IV--Improving liver lipid accumulation]. [Article in Chinese] by Li J1, Zhang XL, Liu YY, Chen L, Tian JY, Han JY, Zhang PC, Ye F.(PubMed)
(2249) [Investigation of a compound, compatibility of Rhodiola crenulata, Cordyceps militaris, and Rheum palmatum, on metabolic syndrome treatment I--improving insulin resistance]. [Article in Chinese] by Li J1, Chen L, Zhang X, Fu J, Han J, Tian J, Zhang P, Ye F.(PubMed)
(2250) [Investigation of a compound, compatibility of Rhodiola crenulata, Cordyceps militaris, and Rheum palmatum, on metabolic syndrome treatment. V--Mechanisms on improving glucose metabolic disorders]. [Article in Chinese] Wang L1, Zhang XL, Li MH, Tian JY, Zhang PC, Ye F.(PubMed)
(2251) Cordycepin from Cordyceps militaris prevents hyperglycemia in alloxan-induced diabetic mice by Ma L1, Zhang S2, Du M3.(PubMed)
(2252) Anti-hyperglycemic activity of natural and fermented Cordyceps sinensis in rats with diabetes induced by nicotinamide and streptozotocin. Lo HC1, Hsu TH, Tu ST, Lin KC.(PubMed)
(2253) Lipid-lowering effect of cordycepin (3'-deoxyadenosine) from Cordyceps militaris on hyperlipidemic hamsters and rats by Gao J1, Lian ZQ, Zhu P, Zhu HB.(PubMed)
(2254) Cordycepin prevents hyperlipidemia in hamsters fed a high-fat diet via activation of AMP-activated protein kinase by Guo P1, Kai Q, Gao J, Lian ZQ, Wu CM, Wu CA, Zhu HB.(PubMed)
(2255) [Investigation of a compound, compatibility of Rhodiola crenulata, Cordyceps militaris, and Rheum palmatum, on metabolic syndrome treatment II - improving obesity]. [Article in Chinese] by Tian JY1, Chen L, Zhang XL, Li J, Han J, Fu JY, Yang XM, Zhang PC, Ye F.(PubMed)
(2256) Blockade of adipocyte differentiation by cordycepin. Takahashi S1, Tamai M, Nakajima S, Kato H, Johno H, Nakamura T, Kitamura M.(PubMed)
(2257) Effect of Cordyceps militaris supplementation on sperm production, sperm motility and hormones in Sprague-Dawley rats by Chang Y1, Jeng KC, Huang KF, Lee YC, Hou CW, Chen KH, Cheng FY, Liao JW, Chen YS.(PubMed)
(2258) Upregulation of steroidogenic enzymes and ovarian 17beta-estradiol in human granulosa-lutein cells by Cordyceps sinensis mycelium by Huang BM1, Hsiao KY, Chuang PC, Wu MH, Pan HA, Tsai SJ.(PubMed)
(2259) Role of Cordycepin and Adenosine on the Phenotypic Switch of Macrophages via Induced Anti-inflammatory Cytokines by Shin S1, Moon S, Park Y, Kwon J, Lee S, Lee CK, Cho K, Ha NJ, Kim K.(PubMed)
(2260) Cordycepin Suppresses Expression of Diabetes Regulating Genes by Inhibition of Lipopolysaccharide-induced Inflammation in Macrophages by Shin S1, Lee S, Kwon J, Moon S, Lee S, Lee CK, Cho K, Ha NJ, Kim K.(PubMed)
(2261) Cardiovascular protection and antioxidant activity of the extracts from the mycelia of Cordyceps sinensis act partially via adenosine receptors by Yan XF1, Zhang ZM, Yao HY, Guan Y, Zhu JP, Zhang LH, Jia YL, Wang RW.(PubMed)
(2262) Protective effect of extract of Cordyceps sinensis in middle cerebral artery occlusion-induced focal cerebral ischemia in rats by Liu Z1, Li P, Zhao D, Tang H, Guo J.(PubMed)
(2263) , inhibit Inhibitory Mechanisms of CME-1, a Novel Polysaccharide from the Mycelia of Cordyceps sinensis, in Platelet Activation by Chang YI, Hsu WH, Lu WJ, Jayakumar T, Liao JC, Lin MJ, Wang SH, Geraldine P, Lin KH, Sheu JR1.(PubMed)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Polycystic Ovarian Syndrome
Unfortunately, according to studies, women with PCOs after the reproductive age, are associated to continuously increase risk of type II diabetes, with no increasingaltered glucose tolerance(20), CVD and hypertension(21).
Management and Treatment according to Traditional Chinese Medicine Perspective
While conventional medicine focus of using synthetic medication to induce ovulation and assisted artificial insemination for infertility couple, if the medicine fail, traditional Chinese medicine views polycystic ovarian syndrome in different approaches.
Polycystic ovary syndrome, according to traditional Chinese medicine is a medical condition characterized by accumulative of fluid over a prolonged period of time causes of dampness and phlegms(1247a)(1247b) build up on the ovaries due to the effects of vary differentiations, affecting not only the women’s menstrual cycle, but also ovulation and fertility(1247a)(1247b).
Depending to differentiation, most common diagnosis of polycystic ovary syndrome can be classified into
Spleen yang deficiency
Spleen yang deficiency is a serve form of spleen qi deficiency, characterized by a condition of inability of spleen in distribution of fluid and nutrient to the body organs, in removal and descend the turbids(2072), causing malfunctions functions of the organs and fluid retention. Prolong period of spleen yang deficiency may induce the development of phlegm, including women with PCOs.
Women with PCOs diagnosed by spleen yang deficiency may also experience yang vacuity impelled cold expression of additional symptoms of abdominal pain(2074), lack of appetite(2076), fatigue(2075), lightheadedness(2075) and headache(2075), weakness of the four limbs(2077), diarrhea(2073)(2076), chilliness(2077), edema(2074), pale, swollen, wet tongue(2076) and weak, slow, deep pulse(2072),....
In the review of the Data base provided by PubMed, spleen qi deficiency may alter certain metabolic pathways, such as the energy, protein, and glycolytic metabolisms(2078), body weight and motor behavior(2079), skeletal muscle function(3080), blood glucose, lipid metabolism and fat-islet axie.(2081),.....
Herbal Medicine recommended for Treatment of PCOs induced by spleen yang deficiency
2. Cordyceps militaris(Dong Chong Xia cao)
Dong chong xia cao, the sweet and warm herb also known as cordyceps sinensis, used in traditional Chinese medicine as immune enhancer(2229)(2230), anti microbial(2231)(2232), anti oxidant(2233)(2234), anti inflammatory(2235)(2236), anti cancer(2237)(2238), cardio-protective(2239)(2240)(2241) agent and for treatment of cirrhosis(2242)(2243), lower back pain (due to it analgesic property)(2244), chronic cough and asthma(2245)(2246), ... as it tonifies yang, nourishes lung yin, transforms phlegm, by enhancing the function of kidney and lung channels(2229).
Phytochemical constituents(2228)
1. Cordyceps polysaccharide
2. Ergosterol
3. Cordycepic acid
4. Amino Acids
5. Lysine
6. Aspartic acid
7. Threonine
8. Taurine
9. Etc.
On metabolic syndrome, in diabetics rat model, Dong chong xia cao inhibited significantly the level of glucose metabolic disorders(2250)(such as hyperglycemia(2251)(2252) by enhancing the glyconeogenesis in serum glucose and lipid profiles(2247), by promoting anti-lipid peroxidation activities and inhibit accumulation of cholesteryl ester in macrophages via suppression of LDL oxidation(2253), regulating the expression of lipoprotein lipase (LPL) and hepatic lipase (HL) activity(2253) and activating protein kinase (AMPK)(2254), improved insulin sensitive(2248)(2249) by inhibiting the activity of human protein tyrosine phosphatase 1B (PTP1B) activity(2249) though metabolism of glucose and lipid(2247)(2248), the microcirculation disturbance(2247)(2248) and the oxidative stress(2247)
On obesity, dong chong xia cao has found to improve the obesity(2255)(2256) through decreased body weight and improved energy uptake(2255) by inhibiting alpha-glycosidase(2255) and adipogenic(2256) and lipid accumulation(2256) activity.
On metabolic syndrome's complications, the herbal medicine reduced risk of diabetes(2259)(2260) and cardiovascular disease(2259) through inhibition of low grade inflammation(2259)(2260) and platelet activation(2263)via immunomodulatory(2259)(2260) and antioxidant activity(2261)(2262).
According to Jenteh Junior College of Medicine and Nursing Management and National Cheng Kung University Medical College, dong chong xia cao improved sex desire(2257), and fertility(2258) through increasing serum testosterone and estradiol-17 (E2) concentrations in production of quality of maturing oocyte, respectively without effecting follicle stimulating hormone (FSH), luteinizing hormone (LH) or prolactin(2257).
Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
References
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(2228) Dong chong xia cao(Complementary and Alternative Healing University)
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(2232) Hot-water extract from mycelia of Cordyceps sinensis as a substitute for antibiotic growth promoters by Koh JH1, Suh HJ, Ahn TS.(PubMed)
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(2234) Anti-oxidation activity of different types of natural Cordyceps sinensis and cultured Cordyceps mycelia by Li SP1, Li P, Dong TT, Tsim KW.(PubMed)
(2235) Anti-inflammatory principles from Cordyceps sinensis by Yang ML1, Kuo PC, Hwang TL, Wu TS.(PubMed)
(2236) Evaluation of the anti-inflammatory and anti-proliferation tumoral cells activities of Antrodia camphorata, Cordyceps sinensis, and Cinnamomum osmophloeum bark extracts by Rao YK1, Fang SH, Tzeng YM.(PubMed)
(2237) Anti-tumor effect of Cordyceps militaris in HCV-infected human hepatocarcinoma 7.5 cells by Lee S1, Lee HH, Kim J, Jung J, Moon A, Jeong CS, Kang H, Cho H.(PubMed)
(2238) Toxicity evaluation of cordycepin and its delivery system for sustained in vitro anti-lung cancer activity by Aramwit P1, Porasuphatana S2, Srichana T3, Nakpheng T3.(PubMed)
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(2241) Role of dongchongxiacao (Cordyceps) in prevention of contrast-induced nephropathy in patients with stable angina pectoris by Zhao K1, Li Y, Zhang H.(PubMed)
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(2245) Cordycepin alleviates airway hyperreactivity in a murine model of asthma by attenuating the inflammatory process by Yang X1, Li Y1, He Y1, Li T1, Wang W2, Zhang J3, Wei J4, Deng Y5, Lin R6.(PubMed)
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(2250) [Investigation of a compound, compatibility of Rhodiola crenulata, Cordyceps militaris, and Rheum palmatum, on metabolic syndrome treatment. V--Mechanisms on improving glucose metabolic disorders]. [Article in Chinese] Wang L1, Zhang XL, Li MH, Tian JY, Zhang PC, Ye F.(PubMed)
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(2253) Lipid-lowering effect of cordycepin (3'-deoxyadenosine) from Cordyceps militaris on hyperlipidemic hamsters and rats by Gao J1, Lian ZQ, Zhu P, Zhu HB.(PubMed)
(2254) Cordycepin prevents hyperlipidemia in hamsters fed a high-fat diet via activation of AMP-activated protein kinase by Guo P1, Kai Q, Gao J, Lian ZQ, Wu CM, Wu CA, Zhu HB.(PubMed)
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(2258) Upregulation of steroidogenic enzymes and ovarian 17beta-estradiol in human granulosa-lutein cells by Cordyceps sinensis mycelium by Huang BM1, Hsiao KY, Chuang PC, Wu MH, Pan HA, Tsai SJ.(PubMed)
(2259) Role of Cordycepin and Adenosine on the Phenotypic Switch of Macrophages via Induced Anti-inflammatory Cytokines by Shin S1, Moon S, Park Y, Kwon J, Lee S, Lee CK, Cho K, Ha NJ, Kim K.(PubMed)
(2260) Cordycepin Suppresses Expression of Diabetes Regulating Genes by Inhibition of Lipopolysaccharide-induced Inflammation in Macrophages by Shin S1, Lee S, Kwon J, Moon S, Lee S, Lee CK, Cho K, Ha NJ, Kim K.(PubMed)
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Most Common Diseases of 50plus: Thyroid disease: Thyroid adenoma Prevention - The Diet
Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Thyroid disease
Thyroid disease is defined as a condition of malfunction of thyroid. Hyperthyroidism is a condition in which the thyroid gland is over active and produces too much thyroid hormones.
Thyroid adenoma
Thyroid adenoma is a benign tumor started in the layer of cell lined the inner surface of the thyroid gland. The disease are relatively common among adults living in the United States. According to the study by the Mayo Clinic and Mayo Foundation, there is a report of 4 patients described in whom a follicular carcinoma developed following thyroidectomy for a benign follicular neoplasm. Most thyroid nodules are Thyroid adenoma.
The Prevention
Diet to prevent Thyroid adenoma
1. Legumes, soy and peanut
Daidzein is a phytochemical in the Isoflavones, belonging to the group of Flavonoids (polyphenols), found abundantly in food of the family of legumes, soy, peanut, etc..In the study to explore whether or not human thyroid cancer cell growth can be curbed by a novel isoflavone derivative generated in our laboratory, the N-t-Boc-hexylenediamine derivative of 7-(O)-carboxymethyl daidzein (cD-tboc), showed that when nude mice carrying ARO thyroid xenografts were treated with cD-tboc, tumor volume decreased significantly, and no apparent toxicity was observed. These results suggest that cD-tboc may be a promising agent for therapy of thyroid carcinoma either alone or in combination with existing cytotoxic drugs(28).
2. Soybean
In the study to observe that an acidic methanolic extract of soybeans contains compounds that inhibit thyroid peroxidase-(TPO) catalyzed reactions essential to thyroid hormone synthesis, showed that In the presence of iodide ion, genistein and daidzein blocked TPO-catalyzed tyrosine iodination by acting as alternate substrates, yielding mono-, di-, and triiodoisoflavones. Genistein also inhibited thyroxine synthesis using iodinated casein or human goiter thyroglobulin as substrates for the coupling reaction(29).
3. Green tea
Epigallocatechin-3-gallate (EGCG), a major catechin in green tea, was shown to possess remarkable therapeutic potential against various types of human cancer cells in in vitro and in vivo models. In the study to investigate the effect of EGCG on the proliferation and apoptosis of ARO cells–human ATC cells, showed that EGCG treatment inhibited the growth of ARO cells in a dose-dependent manner. Furthermore, EGCG suppressed phosphorylation of EGFR, ERK1/2, JNK, and p38. These changes were associated with increased p21 and reduced cyclin B1/CDK1 expression. In addition, EGCG treatment increased the accumulation of sub-G1 cell, activated caspase-3 and cleaved PARP(30).
Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Thyroid disease
Thyroid disease is defined as a condition of malfunction of thyroid. Hyperthyroidism is a condition in which the thyroid gland is over active and produces too much thyroid hormones.
Thyroid adenoma
Thyroid adenoma is a benign tumor started in the layer of cell lined the inner surface of the thyroid gland. The disease are relatively common among adults living in the United States. According to the study by the Mayo Clinic and Mayo Foundation, there is a report of 4 patients described in whom a follicular carcinoma developed following thyroidectomy for a benign follicular neoplasm. Most thyroid nodules are Thyroid adenoma.
The Prevention
Diet to prevent Thyroid adenoma
1. Legumes, soy and peanut
Daidzein is a phytochemical in the Isoflavones, belonging to the group of Flavonoids (polyphenols), found abundantly in food of the family of legumes, soy, peanut, etc..In the study to explore whether or not human thyroid cancer cell growth can be curbed by a novel isoflavone derivative generated in our laboratory, the N-t-Boc-hexylenediamine derivative of 7-(O)-carboxymethyl daidzein (cD-tboc), showed that when nude mice carrying ARO thyroid xenografts were treated with cD-tboc, tumor volume decreased significantly, and no apparent toxicity was observed. These results suggest that cD-tboc may be a promising agent for therapy of thyroid carcinoma either alone or in combination with existing cytotoxic drugs(28).
2. Soybean
In the study to observe that an acidic methanolic extract of soybeans contains compounds that inhibit thyroid peroxidase-(TPO) catalyzed reactions essential to thyroid hormone synthesis, showed that In the presence of iodide ion, genistein and daidzein blocked TPO-catalyzed tyrosine iodination by acting as alternate substrates, yielding mono-, di-, and triiodoisoflavones. Genistein also inhibited thyroxine synthesis using iodinated casein or human goiter thyroglobulin as substrates for the coupling reaction(29).
3. Green tea
Epigallocatechin-3-gallate (EGCG), a major catechin in green tea, was shown to possess remarkable therapeutic potential against various types of human cancer cells in in vitro and in vivo models. In the study to investigate the effect of EGCG on the proliferation and apoptosis of ARO cells–human ATC cells, showed that EGCG treatment inhibited the growth of ARO cells in a dose-dependent manner. Furthermore, EGCG suppressed phosphorylation of EGFR, ERK1/2, JNK, and p38. These changes were associated with increased p21 and reduced cyclin B1/CDK1 expression. In addition, EGCG treatment increased the accumulation of sub-G1 cell, activated caspase-3 and cleaved PARP(30).
Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Sources
(28) http://www.ncbi.nlm.nih.gov/pubmed/21600982
(29) http://www.ncbi.nlm.nih.gov/pubmed/9464451
(30) http://www.ncbi.nlm.nih.gov/pubmed/21725973
(28) http://www.ncbi.nlm.nih.gov/pubmed/21600982
(29) http://www.ncbi.nlm.nih.gov/pubmed/9464451
(30) http://www.ncbi.nlm.nih.gov/pubmed/21725973
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