Saturday, August 13, 2016

Regular Walking Reduces Risk of high triglyceride level Significantly in 50 plus Adults

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Regular physical activity has long been found to associate to the prevention of cancer, cardiovascular disease, and other chronic diseases,  the joint study led by Universidade Federal de Minas Gerais, showed that regular physical activity (PA) induces desirable changes in plasma levels of high- and low-density lipoproteins (HDL and LDL, respectively) and triglycerides (TG), important risk factors for cardiometabolic diseases(4). 

But regular walking contribution of reduced risk of high triglyceride level in the younger and older elderly have been lacking, probably due to the effectiveness of modern diet restriction(2)(3) in syndrome controlling.

High Levels of Triglyceride is a condition of high levels of fat found in the blood. The University of South Carolina study blood lipid and lipoprotein adaptations to exercise suggested, exercise, including brisk walking or jogging, induced energy expenditure is also associated with TC and LDL-C reductions(1).

Regular walking showed to benefit a reduction of body fate stores, endogenous insulin requirements, and food intake, and improved the ability to eliminate cholestrol and triglyceride concentrations by increasing the plasma high density lipoprotein fraction(6).

Dr. Durstine JL and colleagues at the University of South Carolina, said, "Plasma triglcyceride reductions are often observed after exercise training regimens requiring energy expenditure" but the healthy issues would fair better with "a comprehensive medical management plan that optimizes pharmacologic, reduced dietary fat intake, weight loss, and exercise interventions"(5).

Cardiovascular disease, a complication of high blood cholesterol and triglyceride  kills more than 2,000 Americans everyday. Approximately 60 million Americans have heart disease, according to statistic and literature, hyperlipidemia is a well document risk factor for Cardiovascular Disease(7).

Regular Walking also is found to Reduces Risk of Complication of Heart Disease in patients high triglyceride level. A study of 14 obese middle-aged women, after 24 weeks in the exercise program, exhibited significant reduction of weight, body fat, body mass index, waist circumference, systolic blood pressure, diastolic blood pressure, and triglycerides , whereas HDLC, a metabolic improvement factor, increased significantly(8).

Stanford University School of Medicine study of one hundred nineteen of the men and 112 of the women showed that regular exercise in overweight men and women is the best way to enhance the improvement in plasma lipoprotein levels, together with the adoption of a low-saturated-fat, low-cholesterol diet(9).

In support the effectiveness of regular walking in reduced levels of cholesterol and triglycerides, the study of a 10-week Nordic walking training program on the level of GH and LH in elderly women, insisted, regular walking significantly decrease total cholesterol, LDL cholesterol and triglycerides (all on a similar average by between 0.1 and 0.2%), creatine kinase (on average by 14%), lactate dehydrogenase (on average by 4%), C-reactive protein (on average by 24%), and body mass (on average by 5.7%) of that protect against menopause-related catabolic processes(10).

Taking altogether, regular walking when used conjunction with low-saturated-fat, low-cholesterol diet may promote a better result in reduced level of triglycerides, and total cholesterol in compared with baseline of all testing subjects.

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and restore your health naturally with Chinese diet


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References
(1) Blood lipid and lipoprotein adaptations to exercise: a quantitative analysis. by Durstine JL1, Grandjean PW, Davis PG, Ferguson MA, Alderson NL, DuBose KD(PubMed)
(2) [Effects of intrauterine growth restriction and high-fat diet on serum lipid and transcriptional levels of related hepatic genes in rats].[Article in Chinese] by Chen LH1, Liang L, Zhu WF, Wang YM, Zhu JF.(PubMed)
(3) Dietary Interventions and Changes in Cardio-Metabolic Parameters in Metabolically Healthy Obese Subjects: A Systematic Review with Meta-Analysis by Stelmach-Mardas M1,2, Walkowiak J3.(PubMed)
(4) Physical Activity and Lipid Profile in the ELSA- Brasil Study.[Article in English, Portuguese] by Silva RC1, Diniz MF1, Alvim S2, Vidigal PG1, Fedeli LM3, Barreto SM1.(PubMed)
(5) Lipids, lipoproteins, and exercise by Durstine JL1, Grandjean PW, Cox CA, Thompson PD.(PubMed)
(6) Effects of a vigorous walking program on body composition, and carbohydrate and lipid metabolism of obese young men by Leon AS, Conrad J, Hunninghake DB, Serfass R.(PubMed)
(7) Hyperlipidemia as a Risk Factor for Cardiovascular Disease by Robert H. Nelson, MDa,b,(PMC)
(8) Effect of Walking Exercise on Changes in Cardiorespiratory Fitness, Metabolic Syndrome Markers, and High-molecular-weight Adiponectin in Obese Middle-aged Women by Kim DY1, Seo BD2, Kim DJ1.(PubMed)
(9) The effects on plasma lipoproteins of a prudent weight-reducing diet, with or without exercise, in overweight men and women by Wood PD1, Stefanick ML, Williams PT, Haskell WL.(PubMed)
(10) The effect of a 10-week Nordic walking training program on the level of GH and LH in elderly women by Hagner-Derengowska M1, Kałużny K2, Hagner W2, Plaskiewicz A2, Bronisz A3, Borkowska A1, Budzyński J4.(PubMed)

Traditional Chinese Medicine Herbal Therapy - Popular Chinese Herbs - Lai Fu Zi (Semen Raphani)

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Lai Fu Zi (Semen Raphani)


Lai Fu Zi is also known as Radish Seed. The acrid, sweet and neutral herb has been used in TCM to treat burping with acidic gas, cough and wheezing with phlegm, chronic asthmatic
bronchitis, etc., as it promotes digestion, transforms food retention and Phlegm, moves Qi downwards, etc., by enhancing the functions of spleen, stomach and lung channels.

Ingredients
1. Methyl- mercaptan
2. α,β-methylbutanol
3. β, γ-hexenol
4. Eruci acid
5. Linoleic acid
6. Linolenic acid
7. Polysaccharide
8. Phenol
9. Alkaloid,
10 Flavonoid
11. Phytosterols
12. Etc.

Health Benefits
1. Multipotent chemopreventive agent
In the investigation of the chemo0preventive effects of Kaiware Daikon (Raphanus sativus L.) extract, showed that 4-methylthio-3-butenyl isothiocyanate (GRH-ITC) and 4-methylsulfinyl-3-butenyl isothiocyanate (GRE-ITC), released by the GLs purified from Japanese (Kaiware) Daikon (Raphanus sativus L.) seeds and sprouts, had selective cytotoxic/apoptotic activity on three human colon carcinoma cell lines prompted further research on the potential chemopreventive role of a standardized Kaiware Daikon extract (KDE), containing 10.5% w/w GRH and 3.8% w/w GRE, compared to its isolated components(1).

2. Cytotoxic and antioxidant activity
In the interest in the chemopreventive potential of Brassica vegetables (cruciferae), particularly due to their content in glucosinolates (GL), which upon myrosinase hydrolysis release the corresponding isythiocyanates (ITC), as Japanese daikon ( Raphanus sativus L.) is possibly the vegetable with the highest per capita consumption within the Brassicaceae family, found that GRH-ITC has interesting antioxidant/radical scavenging properties, associated with a selective cytotoxic/apoptotic activity toward three human colon carcinoma cell lines, and very limited toxicity on normal human T-lymphocytes(2).

3. Cirrhotic ascites
In the investigation of the efficacy of Xiaozhang Tie, a traditional Chinese herbal cataplasm composed of dahuang (Rheum palmatum L.), laifuzi (Raphanus sativus L.), concocted gansui (Euphorbia kansui T.N. Liou ex T.P. Wang), chenxiang [Aquilaria sinensis (Lour.) Gilg], dingxiang (Eugenia caryophyllata Thunb.), bingpian (Borneolum syntheticum) and shexiang (artificial Moschus), as an adjuvant in treating cirrhotic ascites, indicated that Xiaozhang Tie as an adjuvant to primary therapy of cirrhotic ascites is safe and shows a remarkable efficacy on relieving abdominal distention(3).

4. Anti diabetic effect
In the study of study screening the glycemic attributes of Raphanus sativus L. (Brassicaceae) root juice in normal as well as sub- and mild-diabetic models, found that the dose of 300 mg kg(-1)bw was identified as the most effective dose which lowers the blood glucose level (BGL) by 33.4% (p < 0.001) at 6 h during fasting blood glucose (FBG) studies in normal rats. However, the glucose tolerance test (GTT) revealed the maximum reduction of 15.9% (p < 0.001) in BGL at 3 h in normal rats with the same dose, whereas the reduction observed was by 23.8 and 28.3% (p < 0.001) in sub- and mild-diabetic rats, respectively, at the same interval of time(4).

5. Antioxidant and choleretic properties
In the examination of the Antioxidant and choleretic properties of Raphanus sativus L. sprout (Kaiware Daikon) extract, showed that contribution of GRH to KDE’s antioxidant activity was considered in two chemical assays (Trolox equivalent antioxidant capacity and Briggs-Rauscher methods). The total phenol assay by Folin-Ciocalteu reagent was performed to quantify the reducing capacity of KDE. Finally, on the basis of the putative choleretic properties of antioxidant plant extracts, the effect on the bile flow of KDE administration was investigated in an animal experimental model. The findings showed that KDE has antioxidant properties and significantly induced bile flow in rats administered 1.5 g/kg of body weight for 4 consecutive days(5).

6. Etc.

Side Effects
1. Do not use the herb in case of Qi and spleen deficiency
2. No not use Lai Fu Zi in newborn, children or if you are pregnant or hreast feeding without first consult with your doctor or related field specialist.
3. Etc.

The Best Weight Loss and Healthy recipe: Melon Me smoothie

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.



Recipe contributed by Raw, Quick and delicious! 5 ingredient recipes in just 15 minutes by Douglas McNish, Published by Robert Rose. You can visit them atwww.robertrose.ca

Drink this sweet smoothie first thing in the morning. the fiber in the melon will keep you feeling full until lunch hours.
Tips:
To ripen bananas quickly, place them in a paper bag with an uncut apple and tightly fold over the end of the bag. The apple will emit ethylene gas, which helps to speed ripening. Place the bag in a warm, dry area until the bananas are ripe.
To boost the protein content of your smoothie, try adding a scoop of your favorite protein powder -- I prefer hemp or sprouted brown rice protein. Both are available in natural foods store and well-stocked supermarket. Not all are raw, though, so be sure to read the labels.
1 cup chopped honeydew melon 250 mL
1/2 cup chopped cantaloupe 125 mL
1 banana 1
1 pitted date, chopped
1/4 cup filtered water 60mL
Dash raw vanilla extract Dash
In a blender, combine honeydew, cantaloupe, banana, date, water and vanilla. Blend at high speed until smooth. Serve immediately. make 11/2 cups (375mL)



Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

The Obesity' Research and Studies of Behaviour modification and eating behaviour in adolescent

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Obesity is a medical condition of excess body fat accumulated overtime, while overweight is a condition of excess body weight relatively to the height. According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered over weight, while a BMI of over 30 is an indication of obesity. According to the statistic, 68% of American population are either overweight or obese.

You can calculate your BMI index BMI= weight (kg)/ height (m2)

The Studies of  Behaviour modification and eating behaviour in adolescent


In a study conducted to evaluate the effects of behaviour modification on anthropometric indices and to explore if behaviour modification could improve eating behaviour in adolescents, showed that there were statistically significant differences in changes in body weight (-2.75 kg vs. 0.62 kg), body mass index (-1.07 kg/m(2) vs. 0.24 kg/m(2)) and arm circumference (-2.31 cm vs. 0.5 cm) in the experimental group in contrast to controls (P < 0.001). There were also statistically significant differences in scores for eating behaviour, emotional eating (0.63, 0.17), external eating (0.99, 0.05) and restrained eating (0.72, 0.03) in the experimental vs. the control group respectively (P < 0.001)(1)

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity 
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

(1) "Effect of dietary behaviour modification on anthropometric indices and eating behaviour in obese adolescent girls" by Sabet Sarvestani R, Jamalfard MH, Kargar M, Kaveh MH, Tabatabaee HR.


Dietary Minerals Potassium: The Effect on Chronic kidney disease

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

                                 Dietary Minerals 

Dietary Minerals are the group of minerals which is essential for our body to sustain normal functions and physical health.

                                      Potassium


In General, potassium is a very essential mineral to the human body for maintaining to build proteins and muscle, break down carbohydrates, maintain normal body growth and normal heart electricity, etc.

                                        The Effect on Chronic kidney disease

The benefits
Kidney is an important organ to keep the serum potassium (K+) level in range for normal physiology within the human body. Late stage chronic kidney disease patients are associated with high levels of serum potassium. Other in the study of the incidence of hyperkalemia in dogs with CKD, found hyperkalemia to be associated with commercial renal diets but with potassium-reduced diets hyperkalemia can be corrected.
Chronic kidney disease is a progression of degeneration of kidney function over a prolonged period of time, most often in years.


References
(1) Higher serum potassium level associated with late stage chronic kidney disease by Hsieh MF, Wu IW, Lee CC, Wang SY, Wu MS.(PubMed)
(2) Correction of hyperkalemia in dogs with chronic kidney disease consuming commercial renal therapeutic diets by a potassium-reduced home-prepared diet by Segev G, Fascetti AJ, Weeth LP, Cowgill LD.(PubMed)

Most Common Diseases of 50 Plus: Thyroid disease: Acute thyroiditis - The Diseases associated to

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


                         Thyroid disease


Thyroid disease is defined as a condition of malfunction of thyroid. Hyperthyroidism is a condition in which the thyroid gland is over active and produces too much thyroid hormones.


                         Acute thyroiditis



Acute thyroiditis is defined as a condition of as a result of relatively high amount of iodine in the tissue causes of microbial inflammatory thyroiditis, pyrogenic thyroiditis and bacterial thyroiditis. Acute infectious thyroiditis is very rare, accounting for about 0.1-0.7% of all thyroiditis.

                             The Diseases associated to


1. Tonsillitis
There is a report of a case of a previously healthy, 28-year-old man who, after being affected by tonsillitis, developed suppurative thyroiditis complicated by thyrotoxicosis; a large abscess in the right lobe of the thyroid extending to the thorax introitus, which caused a trachea deviation and compressed large vessels; associated with internal jugular vein thrombosis, and sepsis(17). 

2. Bacterial throat infection
Thyroid abscesses are rare complications of neck infections. There is a report of a case of a teenager who developed increasing neck pain and swelling following treatment for a Streptococcus throat infection. Imaging demonstrated a complex fluid collection in the left thyroid lobe. Ultrasound guided aspiration was performed for diagnostic purposes, yielding purulent fluid that grew multiple bacterial species(18).

3. Thyroid papillary carcinoma
There is a report of a sixty-one-year-old female was admitted to our hospital in October 1988 because of fever and a right neck mass associated with redness and tenderness. The size of the thyroid mass had gradually increased over 3 months. The histologic examination of the resected thyroid revealed the coexistence of encapsulated follicular adenoma, minute papillary carcinoma and chronic thyroiditis. There are few reports of such a case having a combination of suppurative thyroiditis, thyroid cancer and chronic thyroiditis observed in an elderly female(19).

4. Esophageal carcinoma
there is a report of a 68 year old, previously well woman presented with dysphagia, weight loss and a neck swelling. Investigations revealed a right-sided thyroid abscess with fistulous connection to the upper of two oesophageal carcinomas, a previously unreported association(20).

5. Laryngologic problem
There is a report of four cases of acute suppurative thyroiditis treated in our department. Initial symptoms are similar to acute pharyngitis or laryngitis but could end in fulminant course that could be life threatening, according to the Klinika Otolaryngologii CMKP w Warszawie(20a).

6. Graves’ disease and diabetes mellitus
There is a report of a diabetic woman with Graves’ disease in whom thyrotoxicosis occurred after Klebsiella pneumoniae thyroiditis, with relapse nine months after discharge. Thus, the patient’s thyrotoxicosis might not have been caused simply from thyroid tissue destruction by AST, but also as a result of enhancing autoimmune activity. In diabetics, the impairment of chemotaxis and phagocytosis has been noted. Therefore, diabetes mellitus (DM) might have been the precipitating factor for this patient’s acquiring this unusual infection(20b).


Women Health: Premenstrual syndrome(PMS): Causes of Insomnia

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


                                          Premenstrual syndrome(PMS)


Premenstrual syndrome is defined as faulty function of the ovaries related to the women's menstrual cycle, effected over 70% to 90% of women in the US and lesser for women in Southeast Asia because of difference in living style and social structure. The syndrome also interferes women's physical and emotional states, and daily activities as a result of hormone fluctuation and occurs one to two weeks before menstruation and then declines when the period starts.

                              Causes of Insomnia
1. Mineral deficiency
Calcium(1), magnesium(3) are essential for women during menstrual cycle because they have a calming effects for the nervous system(4). Imbalance or deficiency of calcium, magnesium and increase the tension of the brain's cells, causing psychological complaints, including insomnia(5).

2. Vitamin B6 deficiency
Women with PMS are found to have low levels of vitamin B6(6) which is vital to convert tytrophan(7)(8) to serotonin(9). Deficiency of vitamin B6 interferes the production of serotonin, causing reduced the production of melatonin, a vital hormone in promoting a good nigh sleep(11)(12).

3. Alcohol
Alcohol abuse not only damages the liver(13), but also increases the tension of nervous system(14)(15) induced sleep disturbance(16)(17).

4. Caffeine
Caffeine may help to increase nervous system function(18)(19)(20) but it may causes nervous tension(21)(22)and vitamin B6 deficiency(23) in induced PMS, causing unbalance of production of serotonin and melatonin hormone(11)(12) resulting in insomnia.

5. Low levels of melatonin
Melatonin is hormone which helps to regulate the sleep pattern(11)(12) of our body. some women with PMS found to have low levels of melatonin(22)(24) before period caused by low levels of serotonin and tytrophan(7)(8)(9). Intake of food with high in serotonin and tytrophan will help to improve insomnia.

5. Insulin irregularity
Lower insulin-like growth factor-1 concentrations is associated to elevating premenstrual syndrome disorder(2). Researchers exam the inter relationship between insomnia and insulin fluctuation found out that improving insulin balancing will aid the sleep pattern and via versa(25)(26)(27).

Chinese Food Therapy
The Best Way to prevent, treat your disease, 
particular in treatment of menstrual disorder in Women Health


References
(1) http://www.ncbi.nlm.nih.gov/pubmed/17488795
(2) http://www.ncbi.nlm.nih.gov/pubmed/18199422
(3) http://www.ncbi.nlm.nih.gov/pubmed/16197921
(4) http://www.ncbi.nlm.nih.gov/pubmed/16498787
(5) http://www.ncbi.nlm.nih.gov/pubmed/21283430
(6) http://www.ncbi.nlm.nih.gov/pubmed/2558186
(7) http://www.ncbi.nlm.nih.gov/pubmed/3299182
(8) http://www.ncbi.nlm.nih.gov/pubmed/8541642
(9) http://en.wikipedia.org/wiki/Tryptophan
(10) http://www.ncbi.nlm.nih.gov/pubmed/25386956
(11) http://www.ncbi.nlm.nih.gov/pubmed/25454845
(12) http://www.ncbi.nlm.nih.gov/pubmed/25441742
(13) http://www.ncbi.nlm.nih.gov/pubmed/8869667
(14) http://www.ncbi.nlm.nih.gov/pubmed/25490220
(15) http://www.ncbi.nlm.nih.gov/pubmed/25484085
(16) http://www.ncbi.nlm.nih.gov/pubmed/25440381
(17) http://www.ncbi.nlm.nih.gov/pubmed/25369938
(18) http://www.ncbi.nlm.nih.gov/pubmed/24413697
(19) http://www.ncbi.nlm.nih.gov/pubmed/20182043
(20) http://www.ncbi.nlm.nih.gov/pubmed/12399249
(21) http://www.ncbi.nlm.nih.gov/pubmed/1356551
(22) http://www.ncbi.nlm.nih.gov/pubmed/3597168
(23) http://www.ncbi.nlm.nih.gov/pubmed/23855730
(24) http://www.ncbi.nlm.nih.gov/pubmed/23284821
(25) http://www.ncbi.nlm.nih.gov/pubmed/20398173
(26) http://www.ncbi.nlm.nih.gov/pubmed/24816752
(27) http://www.ncbi.nlm.nih.gov/pubmed/18799296