Monday, September 5, 2016

Phytochemicals for Treatment of Liver cancer

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Phytochemials are defined as a group of chemical compound found naturally in plants, including fruits, vegetables, beans, grains, etc. Many studies have proven that they can because of certain phytochemicals, but for what ever reason, there are either no clinical trials follow through or the studies can not make to stage of clinical trials. Do not expect the pharmateutical or foods industrial companies to pay for the researches, as the discovery of the phytochemicals to cure cancers can only dampen the profits of both industries as phytochemicals can not be patented.

Cancer is a class of diseases in which a group of cells growing and multiplying disordered and uncontrollable way in our body, have become progressively worse and damaged other healthy tissues, sometimes spreads to other organs in the body via lymph or blood and results may be in death.
Food intake can help to prevent and treat cancers.


             Liver cancer

 Liver cancer is defined as a condition of out of controlled growth of hepatocellular cells in the liver. Since the organ is a soft tissue with less nerve, most liver cancer patient are diagnosed in the later stage of the cancer. According to the statistic, liver cancer remains the fifth most common malignancy in men and the eighth in women worldwide.
Hepatocellular carcinoma (HCC) is a common form of primary liver cancer.

Types of food to prevent and treat liver cancer
1. Coffee
In the study to examine whether coffee and green tea consumption was associated with a reduced risk of liver cancer by hepatitis virus infection status in the Japan Public Health Center-Based Prospective Study Cohort II, Dr. Inoue M, and research team at the National Cancer Center indicated that a similar risk tendency was observed in those with either or both HCV and HBV infection. In contrast, no association was observed between green tea consumption and the risk of liver cancer in all subjects. Our results suggest that coffee consumption may reduce the risk of liver cancer regardless of HCV and HBV infection status, whereas green tea may not reduce this risk(1).

2. Rice bran
In the study to examine the antioxidant activity and cytotoxic effect of PA extracted from rice bran against selected cancer cell lines (i.e. ovarian, breast andliver cancer), showed that The PA extract from rice bran displayed safe and promising anticancer properties in selected cancer cell lines and it is believed that its antioxidant capability is the likely contributor to the observed anticancer properties(2).

3. Wolfberry
In the study of Hepato-protective potential of carotenoid meso-zeaxanthin [(3R, 3'S)-beta, beta-carotene-3, 3'-diol] in vivo rat models, Dr. v and the research team at the Amala Cancer Research Centre suggested that level of glutathione and antioxidant enzymes, superoxide dismutase, catalase and glutathione peroxidase, in liver tissue was increased by meso-zeaxanthin pretreatment compared to control group during alcohol and CCl4 induced hepatotoxicity. Hydroxyproline, an indicator of fibrosis in liver tissue, decreased remarkably by meso-zeaxanthin administration despite its notable elevation in ethanol treated rats. Histopathological analysis of liver tissue showed the hepatoprotective potential of meso-zeaxanthin(3).

4. Honey
In the study to evaluate the effect of chrysin, a natural, biologically active compound extracted from many plants, honey and propolis, on the tissue and circulatory antioxidant status, and lipid peroxidation in ethanol-induced hepatotoxicity in rats, indicated that Chrysin administration to rats with ethanol-induced liver injury significantly decreased the levels of thiobarbituric acid reactive substances, lipid hydroperoxides and conjugated dienes, and significantly elevated the activity of superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, glutathione-S-transferase and the levels of reduced glutathione, vitamin C and vitamin E in the tissues and circulation compared with those of the unsupplemented ethanol-treated rats. The histological changes observed in theliver and kidney correlated with the biochemical findings(4).

5. Etc.

Chinese Food Therapy
The Best Way to prevent, treat your disease, 
particular in treatment of menstrual disorder in Women Health



Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/19505908
(2) http://www.ncbi.nlm.nih.gov/pubmed/22655458
(3) http://www.ncbi.nlm.nih.gov/pubmed/21365995
(4) http://www.ncbi.nlm.nih.gov/pubmed/19505373

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Women Health: Menstrual Disorders - Secondary menorrhagia Non-hormonal treatment- Cyklokapron (tranexamic acid) in Conventional medicine Perspective

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Menorrhagia is defined as a condition of excessive bleeding in the menstruation phase of the menstrual cycle in the reproductive age of a woman leading to heavy blood loss that can interfere with the woman normal activities, as a result of disruption of normal hormonal regulation of periods or disorders of certain reproductive organs.


                 The Non-hormonal treatment- Cyklokapron (tranexamic acid )

 The medication has been used widely to reduce short-term in people up to 50% with a certain type of bleeding disorder, including menorrhagia.
2. According to the article of Cyklokapron posted in Drug.com
Risks and Side effects of Cyklokapron Injection include
a. In patients with acquired defective color vision, since this prohibits measuring one endpoint that should be followed as a measure of toxicity
b. In patients with subarachnoid hemorrhage. Anecdotal experience indicates that cerebral edema and cerebral infarction may be caused by Cyklokapron in such patients.
c. In patients with active intravascular clotting.
d. In patients with hypersensitivity to tranexamic acid or any of the ingredients.
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Dietary Minerals Chromium(chromium 3+): Chromium picolinate and chromium histidinate protects against renal dysfunction

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

                                 Dietary Minerals 

Dietary Minerals are the group of minerals which is essential for our body to sustain normal functions and physical health.

                                      Chromium(chromium 3+)

Chromium(chromium 3+) is a essential mineral for the body in fat and carbohydrate metabolism, found abundantly in Beef, Eggs, Chicken, Oysters, Wheat germ, Green peppers, Banana, Apple, Etc.

     Chromium picolinate and chromium histidinate protects against renal dysfunction

In the study to investigate the effects of chromium picolinate (CrPic) and chromiumhistidinate (CrHis) on nuclear factor-kappa B (NF-κB) and nuclear factor-E2-related factor-2 (Nrf2) pathway in the rat kidney by the Faculty of Veterinary Science, Firat University, the result show that in kidney tissue CrHis/CrPic increases Nrf2 level, parallelly decreases NF-κB and partially restores IκBα levels in HFD/STZ group, suggesting that CrPic and CrHis may play a role in antioxidant defense system via the Nrf2 pathway by reducing inflammation through NF-κβ p65 inhibition. Moreover, a greater reduction in NF-κB expression and greater increases in expressions of IκBα and Nrf2 in diabetic rats supplemented with CrHis than rats supplemented with CrPic suggest that CrHis has more favorable effects than CrPic(5).
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Women Health: The Obesity and Polycystic ovary syndrome Research and Studies of The potential of the increase in inflammatory markers and metabolic risk of women with the polycystic ovary syndrome (PCOS)

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Obesity is a medical condition of excess body fat accumulated overtime, while overweight is a condition of excess body weight relatively to the height. According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered over weight, while a BMI of over 30 is an indication of obesity. According to the statistic, 68% of American population are either overweight or obese.

You can calculate your BMI index BMI= weight (kg)/ height (m2)

Polycystic Ovarian Syndrome is defined as endocrinologic diseases caused by undeveloped follicles clumping on the ovaries that interferes with the function of the normal ovaries as resulting of enlarged ovaries, leading to hormone imbalance( excessive androgen), resulting in male pattern hair development, acne,irregular period or absence of period, weight gain and effecting fertility. It effects over 5% of women population or 1 in 20 women.

The Studies of  The potential of the increase in inflammatory markers and metabolic risk of women with the polycystic ovary syndrome (PCOS)

 In the study to investigate the relationship between the levels of C-reactive protein (CRP), interleukin-6 (IL-6) and IL-1β and the hormonal and metabolic alterations in women with polycystic ovary syndrome (PCO), conducted by the Humoral Immunity Studies Institute, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, posted in PubMed, showed that the presence of a chronic inflammation status in young women with PCO. These parameters are mainly related to obesity and, to a lesser extent, to IR.
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Children Health: Autism - Causes of Autism

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

                               Autism 

Autism is one of the most common forms of brain development disorder and one in 166 child is diagnosed with some forms of autism. Children who are diagnosed with autism tend to have weak immune system and auto immune problems. Autism is defined as medical condition in which a child has some of the following impairments
a) Speech
b) Social and communication skills
c) Limited interest
d) Repetitive behaviour


                 The Causes of Autism

 1. Antibiotic
The conventional medicine tends to prescribe the mild form of antibiotic for infant and young children, if they are diagnosed with infection or inflammation. The side effect of medication, if overdoses or over uses may increase the risk of nutrient deficiency as resulting of good bacteria being destroyed, causing imbalance of micro bacteria in the digestive system. Also virus tends to produce resistance to antibiotic if overuse, leading to weakened immune system in defend our children's body against other invaders.
2. Vaccination
While organic forms of mercury are more easily absorbed when ingested and some forms of mercury are eliminated from the body very slowly. Methyl Mercury in thimerosal is 50 time more toxic than its organic form. if the child can not remove it through natural secretion, it may be accumulated in the central nervous cell, leading to poisoning and damaging the nervous cells.
3. Environment toxins
There are over 5000 man made chemicals in our environment and most of them are considered very toxins to us. The immune system of our children and infant is not strong as we are, if they are unintentional exposed to highly toxic materials, they may not be able to secret them, causing toxins accumulation in the liver and brain cells, leading to poisoning.
4. Infectious diseases
There are many types of infectious diseases which can be transmitted easily to infants and children, because of imperfection of their immune system such as meningitis, causing inflammation to the central nervous system that damages the brain cells of the infants and children.
5. Food allergic reaction
For what ever reason, certain food chemical compounds which are well tolerated by most of the children, can cause central nervous system inflammation. While the inflammation caused by food allergy can easily treat, but most parents or conventional doctors have made a mistake by not detecting them early, leading to psychological effect of development disorder.
6. Biochemical Abnormality
Some infants was born with low in sulfur amino acid which are important for liver detoxification, causing weakened liver function in eliminating the toxins in the foods, air and drinks, leading to poison entering the blood stream and accumulating in brain, causing psychological problems.
7. Hypothyroidism
Sub clinical hypothyroidism is a type of thyroid disease which can not be detected by conventional blood test, it is often found to associate with symptoms of low temperature, accompanied by cold feet and hands, pale complexion, late teething, difficulty with focusing in school, mood swings and developmental delays or mental retardation, causing weakened immune system and nutrient deficiency, leading to autism.
 Chinese Food Therapy
The Best Way to prevent, treat your disease, 
particular in treatment of menstrual disorder in Women Health


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Overcome Infertility: Sperm-Ubiquitin tag immunoassay (SUTI) of Male Infertility In Conventional medicine Perspective

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

                    Overcome Infertility 

Infertility is defined as inability of a couple to conceive after 12 months of unprotected sexual intercourse. It effects over 5 millions couple alone in the U. S. and many times more in the world. Because of unawareness of treatments, only 10% seeks help from professional specialist.

        Sperm-Ubiquitin tag immunoassay (SUTI) of Male Infertility In Conventional medicine Perspective

I. Definition
The test is to detect the inherited fertility disorder of the infertile male to avoid any unnecessary
fertility treatments for women.

II. Procedure
The semen sperm is taken from the infertile male in the clinic laboratory and the surface of sperm is screened for ubiquintin which is a small, highly-conserved regulatory protein that is ubiquitously expressed in complex structures enclosed within membranes.

III. Diagnosis
Since ubiquitnin is considered a universal marker of semen abnormalities, including sperm head and tail defects and semen contaminants such as spermatids, leukocytes and cellular debris.
The semen example is screened through immunofluorescence and flow cytometry, if there is an displays of increasing binding of anti-ubiquitin antibodies to sperm surface, the sample sperm is considered abnormality which increases the risk of infertility becasues elevated sperm ubiquitin levels have been associated with reduced fertility or infertility.

This test is still in developed state, if proven success, it not only helps to avoid many unnecessary treatments for unfertile couple but also helps to remove damaged sperm from semen sample before IVF and ICSC.
Pregnancy Miracle
Reverse Infertility And Get Pregnant Naturally
Using Holistic Ancient Chinese Medicine


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General Health: Colitis - The Antioxidants

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

                                   Colitis


Colitis is defined as a condition of inflammation of the large intestine, including the colon, caecum and rectum.

                             Types of Colitis

According to the study by Catholic University of the Sacred Heart, types of colitis include
microscopic colitis, ischemic colitis, segmental colitis associated with diverticula, radiation colitis, diversion colitis, eosinophilic colitis and Behcet's colitis(a).

  The Antioxidants

 Antioxidants to prevent colitis
1. Selenium
Selenium deficiency may be implicated in the pathogenesis of some human diseases, including colon cancer. According to the study by Katedry i Zakładu Biochemii i Chemii AM, Katowicach-Ligocie, the inverse correlation between serumselenium concentration and the extension of the disease may be caused by a decreased absorption of selenium from the diseased colon in ulcerative colitis(70).

2. Tomato lycopene
In the study to investigate the effect of TLE on lipopolysaccharide (LPS)-induced innate signaling and experimental colitis, indicate that TLE prevents LPS-induced proinflammatory gene expression by blocking of NF-kappaB signaling, but aggravates DSS-induced colitis by enhancing epithelial cell apoptosis(71).

3. Myricetin
In the study to assess the protective effect of myricetin administered orally at 200, 100 or 50 mg/kg for 10 days in a murine model of acute experimental colitisinduced by dextran sulphate sodium (DSS), showed that treatment with myricetin ameliorated body weight loss in a dose-dependent manner and significantly reduced histology scores. Myricetin decreased the production of nitric oxide (NO), myeloperoxidase (MPO) and malondialdehyde (MDA), while increasing the activity of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px). As it suggested that the anticolitis effects of myricetin may be attributed to anti-inflammatory and antioxidant actions(72).

4. Vitamin E
As a vitamin, vitamin E is a powerful antioxidant and a scavenger of hydroxyl radicals, and it has been shown to have anti-inflammatory activities in tissues. According to the study by Istanbul University Cerrahpasa Medical Faculty, vitamin E administration suppressed these changes in the AA-induced colitis group (p < 0.001). Administration of AA resulted in increased levels of tumour necrosis factor-α, interleukin-1β, interleukin-6, myeloperoxidase and malondialdehyde, and decreased levels of glutathione and superoxide dismutase; vitamin E reversed these effects (all p < 0.001)(73).

5. Melatonin (N-acetylcysteine)
In the study to investigate the effects of melatonin (MT) on the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in rat models of colitis, found that melatonin has a protective effect on colonic injury induced by both acetic acid and TNBS enemas, which is probably via a mechanism of local inhibition of iNOS and COX-2 expression in colonic mucosa(74). Other study also found that melatonin reduces colonic inflammatory injury through downregulating proinflammatory molecule mediated by NF-kappaB inhibition and blockade of IkappaBalpha degradation in rats with colitis(75).

6. N-acetyl-L-cysteine combined with mesalamine
According to the study by Universidad de Alcala, in the evaluation of the effectiveness and safety of oral N-acetyl-L-cysteine (NAC) co-administration with mesalamine in ulcerative colitis (UC) patients, found that Analysis per-protocol criteria showed clinical remission rates of 63% and 50% after 4 wk treatment with mesalamine plus N-acetyl-L-cysteine (group A) and mesalamine plus placebo (group B) respectively (OR = 1.71; 95% CI: 0.46 to 6.36; P = 0.19; NNT = 7.7). Oral NAC combined with mesalamine contrarily to group B (mesalamine alone), the clinical improvement correlates with a decrease of chemokines such as MCP-1 and IL-8. NAC addition not produced any side effects(76).

7. Etc. 
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