Medical Advisor Journals

Wednesday, June 14, 2017

Thyroid hormone: Heart failure and thyroid dysfunction

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Thyroid hormone

Thyroid hormone (triiodothyronine (T3) and thyroxine (T4)), produced by the thyroid gland, plays an important role in regulation of metabolism, including directly boosts energy metabolism and triggers rapid protein synthesis and regulates mitochondrial gene transcription, etc. Iodine is necessary for the production of T3and T4, deficiency of Iodine can lead to enlarge thyroid grand and goitre.

Thyroid hormone: Heart failure and thyroid dysfunction

In the study to review the results of the prospective studies that evaluated the risk of HF in patients with overt and subclinical thyroid disease and discuss the mechanism of this dysfunction, showed that the outcome of this analysis suggests that patients with untreated overt thyroid dysfunction are at increased risk of HF. Moreover, persistent subclinical thyroid dysfunction is associated with the development of HF in patients with serum TSH <0.1 or > 10 mU/l. The timely recognition and effective treatment of cardiac symptoms in patients with thyroid dysfunction is mandatory because the prognosis of HF may be improved with the appropriate treatment of thyroid dysfunction(47).

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Sources
(47) http://www.ncbi.nlm.nih.gov/pubmed/22956554

Tuesday, June 13, 2017

Thyroid hormone: Hypothyroidism

Thyroid hormone: Hypothyroidism

Hypothyroidism is a clinical disorder commonly encountered by the primary care physician. Untreated hypothyroidism can contribute to hypertension, dyslipidemia, infertility, cognitive impairment, and neuromuscular dysfunction. Acording to the study by Dwight D. Eisenhower Army Medical Center, the prevalence increases with age, and is higher in females than in males. Hypothyroidism may occur as a result of primary gland failure or insufficient thyroid gland stimulation by the hypothalamus or pituitary gland. Autoimmune thyroid disease is the most common etiology of hypothyroidism in the United States. Clinical symptoms of hypothyroidism are nonspecific and may be subtle, especially in older persons. The best laboratory assessment of thyroid function is a serum thyroid-stimulating hormone test. There is no evidence that screening asymptomatic adults improves outcomes. In the majority of patients, alleviation of symptoms can be accomplished through oral administration of synthetic levothyroxine, and most patients will require lifelong therapy(45).

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Sources
(45) http://www.ncbi.nlm.nih.gov/pubmed/22962987

Monday, June 12, 2017

Thyroid hormone: Thyroid storm

Thyroid hormone: Thyroid storm

Thyroid storm, also referred to as thyrotoxic crisis, a rare disorder with a sudden onset, rapid progression and high mortality due to hypermetabolic state induced by excessive release of thyroid hormones. There is a report of a case of thyroid storm which had a devastating course, including multiple organ failure (MOF), severe hypoglycemia, disseminated intravascular coagulation (DIC), and stroke. It was difficult to make a diagnosis of thyroid storm in the present patient, because she did not have a history of thyroid disease and her serum FT3 level was normal. Clinicians should be aware that thyroid storm can occur even when there is an almost normal level of thyroid hormones, and that intensive anticoagulation is required for patients with atrial fibrillation to prevent stroke after thyroid storm(44).

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Sources
(44) http://www.ncbi.nlm.nih.gov/pubmed/22975553

Sunday, June 11, 2017

Thyroid hormone: Kidney and thyroid dysfunction

Thyroid hormone: Kidney and thyroid dysfunction

Thyroid hormones influence renal development, kidney structure, renal hemodynamics, glomerular filtration rate, the function of many transport systems along the nephron, and sodium and water homeostasis. In the study by Service de néphrologie, hôpital de Pitié-Salpêtrière, showed that
latients with hypothyroidism can have clinically important reductions in GFR, so screening for hypothyroidism should be considered in patients with unexplained elevations in serum creatinine. patients with thyroid disorders are also at risk for immune-mediated glomerular diseases. Finally, patients with nephrotic syndrome, as well as acute and chronic kidney injury, have alterations in thyroid gland physiology that can impact thyroid function and the testing of thyroid function status(43).

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Sources
(43) http://www.ncbi.nlm.nih.gov/pubmed/23022287

Saturday, June 10, 2017

Thyroid hormone: Depression and thyroid axis function in coronary artery disease

Thyroid hormone: Depression and thyroid axis function in coronary artery disease

In the study to examine the relationship between depression and thyroid axis function in patients with CAD, showed that The patients with CAD with depressive symptoms had a higher prevalence of cardiac failure (p = 0.04), higher NT-pro BNP concentrations (p = 0.02), and lower free triiodothyronine (T3) concentrations (p = 0.04) than patients with CAD but without depressive symptoms. They also showed a strong trend (p = 0.058) toward a higher incidence of the low T3 syndrome. Higher NT-pro BNP concentrations were related to lower total T3 concentrations (r = -0.294, p = 0.011) and to higher reverse T3 concentrations (r = 0.353, p = 0.002). In men, higher scores of depression were related to lower total T3 concentration (r = -0.289, p = 0.034) and to higher NT-pro BNP concentration (r = 0.380, p = 0.005)(42).

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Sources
(42) http://www.ncbi.nlm.nih.gov/pubmed/16649727

Friday, June 9, 2017

Thyroid hormone: Thyroid axis hormones and Fatigue in patients with coronary artery disease

Thyroid hormone: Thyroid axis hormones and Fatigue in patients with coronary artery disease

In people with coronary artery disease, the association between endocrine measures and fatigue is not well understood. We evaluated possible associations of fatigue and exercise capacity with function of adrenal axis and thyroid axis. In the study by Behavioral Medicine Institute, Lithuanian University of Health Sciences in a sample of Sixty-five men and 18 women (mean age 55 years), showed that In coronary artery disease patients, increased thyroid hormone concentrations are associated with decreased physical fatigue and decreased exertion fatigue, and increased cortisol concentrations with decreased mental fatigue. Exercise capacity is not associated with endocrine factors(41).

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Sources
(41) http://www.ncbi.nlm.nih.gov/pubmed/23023678

Thursday, June 8, 2017

Thyroid hormone: Resistance to Thyroid Hormone and Episodes of Thyrotoxicosis

Thyroid hormone: Resistance to Thyroid Hormone and Episodes of Thyrotoxicosis

In the study of a 44-year-old Japanese woman with resistance to thyroid hormone, which was confirmed by the P453A mutation in the thyroid hormone receptor ß (TRß) gene, showed a slight elevation of the basal levels of thyroid hormones, which indicated that her pituitary resistance to thyroid hormone was mild. She experienced a slight exacerbation of hyperthyroxinemia concomitant with TSH suppression, showed that Mild pituitary resistance to thyroid hormone can be overcome by slight exacerbation of hyperthyroxinemia during mild thyrotoxicosis. When pituitary resistance is severe and TSH is not suppressed, thyrotoxicosis may be overlooked(29).

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Sources
(29) http://www.ncbi.nlm.nih.gov/pubmed/23240983