Medical Advisor Journals

Sunday, June 18, 2017

Thyroid hormone: Thyroid hormone and cardiovascular functions

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Thyroid hormone

Thyroid hormone (triiodothyronine (T3) and thyroxine (T4)), produced by the thyroid gland, plays an important role in regulation of metabolism, including directly boosts energy metabolism and triggers rapid protein synthesis and regulates mitochondrial gene transcription, etc. Iodine is necessary for the production of T3and T4, deficiency of Iodine can lead to enlarge thyroid grand and goitre.

Thyroid hormone: Thyroid hormone and cardiovascular functions

Thyroid hormone is well known for its direct effects in regulating cardiovascularfunction and metabolism. In the recent meta-analyses of population-based studies with long-term follow-up have clarified the risk of cardiovascular disorders in patients with subclinical thyroid dysfunction, researchers at the Inwendige Geneeskunde - Endocrinologie en Metabolisme, showed that treatment of patients with TSH levels between 0.1-0.4 mU/l or 4-10 mU/l should depend on other risk factors and patient age, with no treatment for persons with a TSH level of 4-10 mU/l who are older than 65 years(51).

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Sources
(51) http://www.ncbi.nlm.nih.gov/pubmed/23218037

Saturday, June 17, 2017

Thyroid hormone: Hypothyroidism in pregnancy

Thyroid hormone: Hypothyroidism in pregnancy

Hypothyroidism belongs to the most common endocrinopathies affecting women of childbearing age. Accordin g to the study by Medical University of Silesia, Department of Internal Medicine and Clinical Pharmacology, the diagnosis of hypothyroidism in pregnant patients may be complicated by the fact that pregnancy has a considerable impact on thyroid homeostasis. Even overt hypothyroidism in these patients may be characterized by nonspecific signs or symptoms that are easily confused with complaints common to pregnancy itself. Unrecognised or untreated hypothyroidism during pregnancy is associated with adverse outcomes that can be ameliorated or prevented by adequate therapy with thyroxine(49).

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Sources
(49) http://www.ncbi.nlm.nih.gov/pubmed/22891567

Friday, June 16, 2017

Thyroid hormone: Adiposopathy and thyroid disease

Thyroid hormone: Adiposopathy and thyroid disease

Adiposopathy, defined as functionally disturbed adipose tissue mainly composed of large adipocytes and induced by chronic excess of food intake, has been associated with immune, metabolic and endocrine derangements promoting inflammation and, eventually, cardiovascular disease. According to the study by Evgenidion Hospital, University of Athens Medical School, Athens, adiposopathy may positively influence thyrotropin-stimulating hormone, by raising leptin levels, and triggering autoimmunity. In this regard, it is hypothesized that the increased thyrotropin-stimulating hormone is independent of the negative regulation of the thyroid hormone, thereby constituting a secondary phenomenon and not a causal effect(48).

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Sources
(48) http://www.ncbi.nlm.nih.gov/pubmed/22894634

Thursday, June 15, 2017

Thyroid hormone: Hypothyroidism treatments

Thyroid hormone: Hypothyroidism treatments

Hypothyroidism denotes deficient production of thyroid hormone by the thyroid gland and can be primary (abnormality in thyroid gland itself) or secondary/central (as a result of hypothalamic or pituitary disease), according to the study by Department of Endocrinology and Metabolism, All India Institute of Medical Sciences, treatment of hypothyroidism can be started with the full calculated dose for most young patients. However, treatment should be initiated at a low dose in elderly patients, patients with coronary artery disease and patients with long-standing severe hypothyroidism. In primary hypothyroidism, treatment is monitored with serum TSH, with a target of 0.5-2.0 mIU/L. In patients with central hypothyroidism, treatment is tailored according to free or total T4 levels, which should be maintained in the upper half of the normal range for age. In patients with persistently elevated TSH despite an apparently adequate replacement dose of LT4, poor compliance, malabsorption and the presence of drug interactions should be checked. Over-replacement is common in clinical practice and is associated with increased risk of atrial fibrillation and osteoporosis, and hence should be avoided(46).

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Sources
(46) http://www.ncbi.nlm.nih.gov/pubmed/22191793

Wednesday, June 14, 2017

Thyroid hormone: Heart failure and thyroid dysfunction

Thyroid hormone: Heart failure and thyroid dysfunction

In the study to review the results of the prospective studies that evaluated the risk of HF in patients with overt and subclinical thyroid disease and discuss the mechanism of this dysfunction, showed that the outcome of this analysis suggests that patients with untreated overt thyroid dysfunction are at increased risk of HF. Moreover, persistent subclinical thyroid dysfunction is associated with the development of HF in patients with serum TSH <0.1 or > 10 mU/l. The timely recognition and effective treatment of cardiac symptoms in patients with thyroid dysfunction is mandatory because the prognosis of HF may be improved with the appropriate treatment of thyroid dysfunction(47).

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Sources
(47) http://www.ncbi.nlm.nih.gov/pubmed/22956554

Tuesday, June 13, 2017

Thyroid hormone: Hypothyroidism

Thyroid hormone: Hypothyroidism

Hypothyroidism is a clinical disorder commonly encountered by the primary care physician. Untreated hypothyroidism can contribute to hypertension, dyslipidemia, infertility, cognitive impairment, and neuromuscular dysfunction. Acording to the study by Dwight D. Eisenhower Army Medical Center, the prevalence increases with age, and is higher in females than in males. Hypothyroidism may occur as a result of primary gland failure or insufficient thyroid gland stimulation by the hypothalamus or pituitary gland. Autoimmune thyroid disease is the most common etiology of hypothyroidism in the United States. Clinical symptoms of hypothyroidism are nonspecific and may be subtle, especially in older persons. The best laboratory assessment of thyroid function is a serum thyroid-stimulating hormone test. There is no evidence that screening asymptomatic adults improves outcomes. In the majority of patients, alleviation of symptoms can be accomplished through oral administration of synthetic levothyroxine, and most patients will require lifelong therapy(45).

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Sources
(45) http://www.ncbi.nlm.nih.gov/pubmed/22962987

Monday, June 12, 2017

Thyroid hormone: Thyroid storm

Thyroid hormone: Thyroid storm

Thyroid storm, also referred to as thyrotoxic crisis, a rare disorder with a sudden onset, rapid progression and high mortality due to hypermetabolic state induced by excessive release of thyroid hormones. There is a report of a case of thyroid storm which had a devastating course, including multiple organ failure (MOF), severe hypoglycemia, disseminated intravascular coagulation (DIC), and stroke. It was difficult to make a diagnosis of thyroid storm in the present patient, because she did not have a history of thyroid disease and her serum FT3 level was normal. Clinicians should be aware that thyroid storm can occur even when there is an almost normal level of thyroid hormones, and that intensive anticoagulation is required for patients with atrial fibrillation to prevent stroke after thyroid storm(44).

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Sources
(44) http://www.ncbi.nlm.nih.gov/pubmed/22975553