All About Green Tea: Green Tea Bioactive Epigallocatechin-3-Gallate (EGCG) Attenuated Risk and Treatment of Atherosclerosis

Green tea may have a therapeutic and positive effect in reduced risk and treatment of atherosclerosis, some scientists suggested.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.

Atherosclerosis is medical condition characterized by the deposition of plaques of fatty material on the inner walls, causing to hardening of the arterial vessels.

According to statistic, mortality rate of coronary heart disease was about 60% in 2010 in compared to 30% of stroke and heart failure.

In the study to determine the effect of green tea bioactive epigallocatechin-3-gallate (EGCG) in ameliorated Porphyromonas gingivalis -induced atherosclerosis in a murine model, after injection of the extract EGCG, the tested mice than fed high-fat diets and injected with P. gingivalis three times a week for 3 weeks, observation at weeks 15 displayed a significant reduction of atherosclerotic plaques accumulated in the branches of arteries, observed by Oil Red O staining

Further analysis also found that the polyphenol extract decreased infection of atherosclerotic lesion areas in the anatomic dilations of the ascending aorta through decreased expression of C-reactive protein, in regulated the acute phase of infection and monocyte chemoattractant protein-1 (MCP-1/CCL2) chemokines in regulated migration and infiltration of monocytes/macrophages.of immune system in induced production of cytokines to counter foreign substances.

Additional observation, also indicated that green tea bioactive epigallocatechin-3-gallate (EGCG) not also improved LDL/very LDL cholesterol but also ameliorated ROS activity via antioxidant in induced low-density lipoprotein (LDL) oxidation, a leading indication of plague accumulation.

In depth differentiation, the efficacy of green tea epigallocatechin-3-gallate (EGCG) in reduced expression of atherosclerosis due to bacterial P. gingivalis was attributed to decrease secreted proteins with functions in stimulated inflammatory effects, such as chemokines (CCL2) involved in immunoregulatory and inflammatory processes, matrix metallopeptidase 9 (MMP-9) in regulated pathological remodeling processes that involve inflammation, ICAM-1 (Intercellular Adhesion Molecule 1) involvesd inflammation of capillary vessel walls, the mitochondrial chaperonin hsp60 in induction of inflammation,......

Interestingly, in the process to prevent plague to initiation of development of atherosclerosis through above implications, green tea epigallocatechin-3-gallate (EGCG) also increased levels of antioxidant defense enzyme (heme oxygenase-1 mRNA) HO-1 mRNA levels in reduced expression of oxidative stress in induction of pathogenic inflammatory diseases.

Intrusively, continued investigated the effect of epigallocatechin-3-gallate (EGCG) in inhibit the formation and development of atherosclerosis via its anti inflammatory capability also found that EGCG restricts the function of IL6 (interleukin 6) in induced over expression of pro inflammatory cytokines and Angiotensin (Ang) II functions in stimulated and increased vascular permeability through production of vascular endothelial cell growth factor CRP in initiated the pro inflammatory process.

Interleukin 6 is an interleukin with duo functions of pro inflammatory cytokines and anti inflammatory mytokines.

Amazingly, antioxidant activities of EGCG also acted as free radical scavengers to prevent ROS to establish a chain reaction in induction of inflammatory effect in encouraging lipid accumulation in the inner wall of arteries, the leading cause of atherosclerosis.

ROS are free radical with function to mediate many pathophysiological processes, such as growth, migration, apoptosis and secretion of inflammatory cytokines,

Angiotensin is a hormone with function in regulated vasoconstriction in increased blood pressure.

Application of combined (-)-Epigallocatechin gallate (EGCG) +chitosan (CS) and aspartic acid (PAA). demonstrated a significant effect in reduced risk and treatment of atherosclerosis through ameliorated lipid deposition in tested animals.
In compared to the effects of conventional medicine simvastatin with approximately successful treatment rate of lipid deposition of 15.6%, injection of (-)-Epigallocatechin gallate (EGCG) +chitosan (CS) and aspartic acid (PAA).exhibited over all treatment rate of 16.9%.

The accounted evidences suggesting that EGCG, as a natural substance, may have a substantial and therapeutic effect in attentuated risk and treatment of atherosclerosis through anti-inflammatory and antioxidative activities..

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sourcesase
(1) Green tea epigallocatechin-3-gallate attenuates Porphyromonas gingivalis -induced atherosclerosis by Yu Cai Tomoko Kurita-Ochiai Tomomi Hashizume Masafumi Yamamoto(Pathogen and Disease)
https://academic.oup.com/femspd/article/67/1/76/2367414
(2) Improving the effectiveness of (-)-epigallocatechin gallate (EGCG) against rabbit atherosclerosis by EGCG-loaded nanoparticles prepared from chitosan and polyaspartic acid by Hong Z1, Xu Y, Yin JF, Jin J, Jiang Y, Du Q.(PubMed)
(3) Epigallocatechin-3-gallate inhibits interleukin-6- and angiotensin II-induced production of C-reactive protein in vascular smooth muscle cells by NingPeng, Jun-tian Liu Fang. Guo. Rui Li(Science Direct)

All About Green Tea: Green tea in Attenuated Risk and Treatment of Bladder Cancer

Green tea may have a therapeutic and sustainable effect in reduced risk and treatment of bladder cancer, some scientists suggested.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.

Bladder cancer is medical condition characterized by irregular cell growth in the issues of bladder. At the later stage, the cancerous cell may travel a distance away to invade other healthy tissues and organs.

According to statistic provided by cancer.net, 90% of people with bladder cancer are older than 55, and the average age of people diagnosed with bladder cancer is 73


In the review of medical literature published online, green tea major catechin EGCG in reduced risk and treatment may be attributed to numbers of mechanisms.

In T24 human bladder cancer cell line, application of the chemopreventive/antiproliferative potential of (-)-epigallocatechin gallate (EGCG, the major phytochemical in green tea) induced anti malignant cell proliferation by modulating the expression of phosphatidylinositol 3' kinase/Akt in activated Bcl-2 family proteins with function in regulation of cell death, thus enhancing apoptosis of T24 bladder cancer cell line in dose- and time-dependent manner.


The phosphatidylinositol 3'-kinase/AKT pathway is a crucial regulator of cellular processes including cell proliferation and apoptosis.


Bcl-2 family proteins is a modulator responsible for regulation of cell apoptosis.

In C3H/HeN mice subcutaneously implanted with MBT-2 murine bladder tumor cells, administration of EGCGs physically attached onto the surface of nanogold particles pNG(EGCG-adsorbed pNG) exerted a significant anti cancer proliferation through induction of apoptosis.

This action of anti cancer effect was attributed to mechanism of EGCG-pNG in activation of caspases which plays an important role in induced cell apoptosis and inflammation through Bcl-family proteins with function in control apoptosis by activating caspase proteases in the governing the space between outer and inner mitochondrial membrane.

Under stress, the mitochondrial pathway or the intrinsic pathway is activated depending to the release of proteins from the intermembrane space of mitochondria.

Caspase cascade, a family protease enzymes with function in programmed cell death and inflammation.

Additionally, injecting EGCG-pNG directly into the tumor site inhibited tumor expansion through ameliorated the function of vascular endothelial growth factor (VEGF) in stimulated formation of new blood vessel in provided nutrients and oxygen for survival of cancer site in compared to
oral administration of EGCG in stimulated immune function in suppression of cancer progression.



Vascular endothelial growth factor, is a signal protein produced by cells in stimulated formation of blood vessel for cell division and site proliferation.


Based on information collected,, the prepared EGCG-pNG was more effective than free EGCG in inhibiting bladder tumor in model mice.

More interestingly, bladder tumor induced by N-butyl-(-4-hydroxybutyl) nitrosaminre (BBN) 0.05% solution on 8 week-old female C3H/He mice for 14 or 24 weeks on treatment with or without green tea polyphenols (GTP) expressed a significant lower rate of tumor invasive frequency of 23.8%; in group treated with both GTP and BBN in compared to 65.2% in group treated with BBN alone.



The tumorvolume and microvascular density (MVD) as an independent predictor within a tumor.and the connective, functionally supportive framework of a biological cell, tissue, or organ region in the BBN+GTP group were also significantly lower than in BBN treated mice.


Unbelievably, green tea polyphenols inhibited tumor growth and invasion in mice with established bladder cancer through regulation of angiogenetic effect in suppressed the forming of new blood vessel for the tumor cells proliferation, metastatic spread, as well as providing oxygen and nutrients and removal of waste products of cancer cells without exhibiting anti-carcinogenic effect.

Taken together, green tea extract polyphenols may be considered as adjunct therapy for reduced risk and used combination with standard medicine for treatment of bladder cancer.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) A component of green tea, (-)-epigallocatechin-3-gallate, promotes apoptosis in T24 human bladder cancer cells via modulation of the PI3K/Akt pathway and Bcl-2 family proteins by Qin J1, Xie LP, Zheng XY, Wang YB, Bai Y, Shen HF, Li LC, Dahiya R.(PubMed)
(2) The treatment of bladder cancer in a mouse model by epigallocatechin-3-gallate-gold nanoparticles by Hsieh DS1, Wang H, Tan SW, Huang YH, Tsai CY, Yeh MK, Wu CJ.(PubMed)
(3) Green tea polyphenol suppresses tumor invasion and angiogenesis in N-butyl-(-4-hydroxybutyl) nitrosamine-induced bladder cancer by Sagara Y1, Miyata Y, Nomata K, Hayashi T, Kanetake H.(PubMed)

All About Green Tea: Green tea in Reduced Risk and Treatment of Esophageal Cancer

Green tea may have a therapeutic and positive effect in reduced risk and treatment of esophageal cancer, some scientists suggested.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.

Esophageal cancer is medical condition characterized by irregular cell growth in the tissues of esophagus. At the later stage, the cancerous cells may travel a distance away to invade other healthy tissues and organs.
According to statistic, 2,300 Canadians will be diagnosed with esophageal cancer in 2017.

In the review of literature published online, green tea efficacy in treatment of human esophageal squamous cell carcinoma was expressed in number of mechanisms.


In esophageal cancer cell lines Eca109 and Ec9706, injection of green tea EGCG plus chemodrug adriamycin (ADM) after 24 hours displayed a significantly increased cellular apoptosis.

According to flow cytometry assay, the application induced the elevation of ROS and ADM concentration in production of toxicity to counter the reaction of tumor cell in diminished expression of mitochondrial membrane potential and ABCG2 protein to induced apoptosis.without harming to healthy cells.

ABCG2 protein expression plays a major role in multi-drug resistance, produced by tumor cells to accounter reaction to chemo-medicine.
Mitochondrial membrane potential is a central intermediate in oxidative energy metabolism, the deceased levels caused by toxicity ROS may result in energy deletion and subsequently, causing cells death.



Further observation also indicated that EGCG inhibited the growth of Eca109 and Ec9706 cells through ameliorated the anti apoptotic bcl-2 protein expression and promoted bax and caspase-3 protein expressions with functions in induced apoptosis in a dose- and time- dependent manner.


BCL2 family members form hetero- or homodimers and plays an important anti-apoptotic protein.

Caspase-3 protein.plays a central role in the execution-phase of cell apoptosis.

BAX gene. BAX is a member of the Bcl-2 gene family. plays an important role in mediation of cell death by apoptosis.


Compared to ADM treatment alone, the Eca109/ABCG2 multi-drug resistance cancer cells, rate of apoptosis and ADM concentration were significant higher anid levels of mitochondrial membrane potential and ABCG2 expression were lower.

In other word, injection of green tea plus ADM was more effective in induced cells death in Eca109/ABCG2 multi-drug resistance cancer cells with expression ROS and ADM in enhanced elevation cytotoxity activity in compared to ADM treatment alone.

After taking into account of others confounders, Dr, Liu L the lead author said, " EGCG inhibited cell growth and induced esophageal cancer cell apoptosis. It reduced the bcl-2 protein expression and increased the bax and caspase-3 protein expression. EGCG reversed multi-drug resistance by reducing ABCG2 expression and increasing the anticancer drug concentration in cancer cells".




In esophageal squamous cell carcinoma, application of Epigallocatechin-3-gallate (EGCG) without ADM measured by flow cytometry assay, after 24 hours also inhibited cancer site proliferation by increased expression of ROS to attenuate mitochondrial membrane potential function in energy metabolism and caspase-3 protein to cause malignant cellular apoptosis, in a dose-and time-dependent manner.

In the examine the PCR-TRAP argentation analysis during the experiment, EGCG was also demonstrated to inhibit the viability of Eca109 and Ec9706 cells by suppressing cancer cell in alternated DNA transcript through telomerase activity.

More interestingly, the continuation of study of epigallocatechin-3-gallate (EGCG) on the human esophageal cancer cell line ECa109 also discover that EGCG demonstrated a decrease of cancer cell viability but a substantial rate of apoptosis by increased expression of p16 gene demethylation in induced cancer cell cycle arrest and apoptosis, level p16 mRNA expression in suppressed tumor progression of invasive and aggressive behavior.and p16 protein expression in promoted tumor suppressible activity, in a dose- and time-dependent manner.


P16 gene demethylation plays an important role in cell cycle arrest and apoptosis. gene alternation was found in several types of cancer.
Low level of p16 mRNA expression is associated to progression of cancer with malignant and aggressive behavior.


Abnormalities of p16 gene and loss of p16 protein expression may be related to the pathogenesis and development of some cancers.


Taken together, green tea with abundance of phytochemical Epigallocatechin-3-gallate (EGCG) may be considered as an adjunct therapy to combine with standard chemo-medicine in reduced risk and treatment of esophageal cancer.



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Epigallocatechin-3-gallate promotes apoptosis and reversal of multidrug resistance in esophageal cancer cells by Liu L1, Ju Y2, Wang J3, Zhou R3.(PubMed)
(2) Epigallocatechin-3-gallate suppresses cell proliferation and promotes apoptosis in Ec9706 and Eca109 esophageal carcinoma cells by Liu L1, Zuo J1, Wang G1.(PubMed)
(3) Epigallocatechin-3-gallate inhibits growth and induces apoptosis in esophageal cancer cells through the demethylation and reactivation of the p16 gene by Meng J1, Tong Q2, Liu X2, Yu Z3, Zhang J3, Gao B3.(PubMed)

All About Green Tea: Green tea in Ameliorated Risk and Treatment of Leukemia

Green tea may have positive and potential effect in reduced risk and treatment of leukemia, according to studies of some scientists.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.

Leukemia is a malignant progressive disease characterized by irregular cell growth in the bone marrow and other blood-forming organs. According to the statistic, approximately Over 300 children with 0-14 years of age are diagnosed with leukemia each year in Canada alone.

In the review of literature published online, green extract epigallocatechin‑3-O-gallate (EGCG) processed a significant anti cancer effect in reduced chronic myeloid leukemia (CML) expansion in the myeloid cells through numbers of mechanisms.

Application of green tea epigallocatechin‑3-O-gallate (EGCG) in reduced risk of chronic myeloid leukemia (CML) was found to associate to the cellular process of cyclic guanosine monophosphate (cGMP)-dependent pathway and protein kinase Cδ expression to induce cancer cells apoptosis by increased acid sphingomyelinase (ASM) and lipid raft clustering in CML cells.


Acid sphingomyelinase (ASM), an enzyme plays an important role in normal membrane turnover.

Protein kinase Cδ expression plays a key role in signal transduction and are involved in the regulation of numerous cellular processes.


Cyclic guanosine monophosphate (cGMP)-is a important second messenger in many biological processes involved a series of molecular functions.

Further analysis also suggested that exhibited sGC function by injection of green tea EGCG, may be an ideal approach to suppresses proliferation and survival of human CML

In other words, reduced expression of regulation of sGC caused by decreased NO production may initiate growth and survival advantage in CML tumor cells.


Soluble guanylyl cyclase (sGC) is the only known receptor for nitric oxide.

Pharmacologically, pretreatment of soluble guanylate cyclase inhibitor NS-2028 decreased nitric oxide (NO)-stimulated sGC activity also reduced green tea polyphenol activities in activated sphingomyelinase (ASM) production.

NS-2028 is a specific inhibitor of soluble guanylyl cyclase.


In acute promyelocytic leukemia (APL), green tea (Camellia sinensis) catechin epigallocatechin-3-gallate (EGCG) displayed a strong and positive effect in elevating the expression of genes associated with cell cycle arrest and differentiation, including gene expression p27, PCAF, C/EBPα, and C/EBPɛ



P27, a cyclin-dependent kinase inhibitor 1B is an enzyme inhibitor and in elevation exerted positive regulation of cancer activity at the G1/S phase transition in cell division.


P300/CBP-associated factor (PCAF), is gene associated in binding to many sequence-specific factors involved in cell growth and/or differentiation.


Enhancer binding protein alphaC/EBPα, with function in modulated the expression of genes involved in cell cycle regulation.


Enhancer binding protein epsilon (C/EBPɛ) is a protein composed of two polypeptide chains with function in binding to certain DNA regulatory regions.

Additionally,injection of EGCG also demonstrated a hugh effect against cancerous changes in gene expression and reduced expression of epigenetic modifiers DNMT1, HDAC1, HDAC2, and G9a.


DNA Methyltransferase, (DNMT1), Methylation of DNA is an important component of mammalian epigenetic gene regulation.


Histone deacetylase 1and 2 (HDAC1 and 2) are enzymes promote epigenetic repression and with function in transcriptional regulation, cell cycle progression and development.


Euchromatic histone-lysine N-methyltransferase 2 (EHMT2) or G9a.is an epigenetic modifier enzymes with function in regulating gene expression involved functional role of cancer initiation and progression. Down regulation of G9a also decreased expression of histone H3K9 (H3K9me2) in inhibited cancer cells proliferation

Other, in the multicenter case-control study conducted in China, 2008-2013, comprising 442 incident, hematologically confirmed adult leukemia cases and 442 outpatient controls, individually matched to cases by gender, birth quinquennium by the University of Western Australia also confirmed the inverse association of green tea intake to adult leukemia risk.

Risk of leukemia adjusted odds ratios of 0.50 was found in green tea drinkers in compared to non drinker, particularly in patients with GSTM1 and GSTP1 genotypes.

Dr. Liu P, the lead author said, "regular daily green tea consumption may reduce leukemia risk in Chinese adults regardless of GSTM1 and GSTP1 polymorphic status. The association between green tea and adult leukemia risk varied with GSTT1 genotype".


Taking altogether, green tea and epigallocatechin‑3-O-gallate (EGCG) intake may be considered as secondary therapeutic application combined with standard therapy for treatment of Leukemia regardless to polymorphic status.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Green tea polyphenol epigallocatechin-O-gallate induces cell death by acid sphingomyelinase activation in chronic myeloid leukemia cells.by Huang Y1, Kumazoe M1, Bae J1, Yamada S1, Takai M1, Hidaka S1, Yamashita S1, Kim Y1, Won Y1, Murata M1, Tsukamoto S1, Tachibana H1.(PubMed)
(2) Green tea polyphenol EGCG causes anti-cancerous epigenetic modulations in acute promyelocytic leukemia cells by Borutinskaitė V1, Virkšaitė A1, Gudelytė G1, Navakauskienė R1.(PubMed)
(3) Green tea consumption and glutathione S-transferases genetic polymorphisms on the risk of adult leukemia by Liu P1, Zhang M2,3, Xie X4, Jin J5, Holman CD2.(PubMed)

All About Green Tea: Green tea in Ameliorated Risk and Treatment of Endometrial Cancer

Scientist may have a popular beverage in reduced risk and treatment of endometrial cancer, according to some studies.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.

Endometrial cancer is a medical condition characterized by cell growth uncontrollably in the endometrium. At the late stage, cancerous cell may travel a distance away from the original site to infect other organs and tissues.

In the review of researcher papers online, the effects of green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG) in inhibition of endometrial cancer was expressed in various aspects.


In the experiment of green tea bioactive compound against progression of tumor xenografts of human endometrial cancer, (-)-epigallocatechin-3-gallate EGCG demonstrated a significant effect in reduced risk of endometrial cancer development through the bioactive chemicals anti tumor angiogenesis properties.

In fact, the anti cancer active compound efficacy was attributed to the modulation of expression of vascular endothelial growth factor A (VEGFA) protein in the established new vessel to stimulate the onset of cancer and cancer cell proliferation and HIF-1 functions in activated transcription of many genes, in regulated cellular and systemic homeostatic response to external changes to tumor growth.

Furthermore, application of EGCG also suppressed responses of chemokine (C-X-C motif) ligand 12 (CXCL12) in expression of multiple physiological processes, in promoted invasion and metastasis of tumor cells in connected tissues of the uterine mucosa (endometrium), thus reducing the infiltration of VEGFA-expressing tumor-associated macrophages (TAMs) in supplying rapidly growing malignant tissues with essential nutrients and oxygen.


Additionally, further analysis also insisted that EGCG restricted secretion of vascular endothelial growth factor A (VEGFA) in initiated endometrial cancer growth by inhibiting the function of PI3K/AKT/mTOR/HIF1α pathway in regulated many cellular processes, including cell survival, proliferation, and growth.


After taking account of all findings, treatment with EGCG reduced risk of endometrial cancer onset may be results of EGCG suppressed secretion in both fronts including decreased cancer cell-secreted VEGFA but inhibited TAM-secreted VEGFA in endometrial cancer progression.
Further differentiation, also showed that green tea polyphenol (-)-epigallocatechin-3-gallate reduced cancer expansion by suppressing the expression of proliferation markers which acts indirectly to stimulate endometrial epithelial proliferation in estrogen receptor α, progesterone receptor, proliferating cell nuclear antigen and cyclin D1


The overexpression of cyclin D1 has been linked to the development and progression of cancer.

Proliferating cell nuclear antigen is a protein with function in cell cycle regulation and/or DNA replication and important for both DNA synthesis and DNA repair.
Importantly, the inhibition of EGCG also decreased the activation of ERK, the extracellular signal–regulated kinases protein in cancer cell division and down expression of transcription factors fos and jun, the cellular immediate-early genes in induced transient cancer cell division and differentiation processes.

The function of EGCG in reduced risk of endometrial cancer also expressed through Bcl-2-associated X protein, cleavage of caspase-3 and poly(ADP-ribose) polymerase actions in induction of cancer cell apoptosis and suppression of antiapoptotic protein Bcl-2 (B-cell lymphoma 2).


Bcl-2-associated X is a protein with function of anti- or pro-apoptotic regulators involved in a wide variety of cellular activities.

B-cell lymphoma 2, a family protein with function in regulation of cell apoptosis.

Cleavage of caspase-3 also is known as a critical executioner of apoptosis,


Poly(ADP-ribose) polymerase is a protein with function involved in a number of cellular processes, including programmed cell death.

Implicitly, application of EGCG also increased production of free radical expression in initiated the cytoxicity effect by reduced levels of antioxidant glutathione levels and activated the p38 in cancer cells death without inducing toxicity to normal cells



P38 mitogen-activated protein kinases (MAPKs) are activated by a wide range of cellular stresses as well as in response to inflammatory cytokines involved in cell differentiation, apoptosis and autophagy.


In deed, according to a systematic review of literature published on database of PubMed, Embase, Cochrane Library and China Biological Medicine Database upto February 2, 2015 , researchers indicated that green tea consumption was associated with a reduced risk of EC with a relative risk of .78 and each additional cup of green tea consumed per day decreased risk of developing EC by 11%.

Particularly, intake of green tea associated to attenuated risk of endometrial cancer was 84.33% in compared to 5.07 % of black tea.

Taken together, green tea, and its polyphenol (-)-epigallocatechin-3-gallate EGCG may be considered a functional food used conjunction with standard therapy in reduced risk and treatment of endometrial cancer.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Green tea, black tea consumption and risk of endometrial cancer: a systematic review and meta-analysis by Zhou Q1, Li H2, Zhou JG3, Ma Y4, Wu T5, Ma H6.(PubMed)
(2) A prodrug of green tea polyphenol (-)-epigallocatechin-3-gallate (Pro-EGCG) serves as a novel angiogenesis inhibitor in endometrial cancer by Wang J1, Man GCW2, Chan TH3, Kwong J1, Wang CC4.(PubMed)
(3) (-)-Epigallocatechin-3-gallate induces apoptosis in human endometrial adenocarcinoma cells via ROS generation and p38 MAP kinase activation by Manohar M1, Fatima I, Saxena R, Chandra V, Sankhwar PL, Dwivedi A.(PubMed)

All About Green Tea: Green tea in Ameliorated Risk and Treatment of of Lymphoma

Green tea may have a sustainable and profound effect in reduced risk and treatment of lymphoma, some scientists suggested.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world. 

Lymphoma is a medical condition characterized by cell growth disorderly and uncontrollably in the lymph nodes.There were 661,996 people living with non-Hodgkin lymphoma in the United States, 2014.

According to the medical literature online, intake of green tea saponin and phenolic may have a strong influence in lymphoma oncogenesis through some certain aspects.

In EL4 cancer cells line, injection of green bioactive saponin stimulated the immunomodulatory activity in inhibited EL4 cells line through regulated cytokine expression induced by inflammation and mitogen-activated protein kinases (MAPK) signaling pathway involved in a variety of fundamental cellular processes such as proliferation, differentiation, motility, stress response, apoptosis, and survival.

Furthermore, injected saponin also reduced the expression of EL4 cells line in tumor proliferation by interrupting the process of sequence of mutated DNA transcript in mRNA expression in transmitting transcript by initiating production of inflammatory cytokines to reverse transcription polymerase chain reaction in making copies of alternated gene, thus attenuating risk of tumor growth, tumor progression and immuno-suppression, activities in host anti-tumor response.



Treatment of green tea saponin also was found to induced cytotoxicity to EL4 cancer cell line without causing harm to healthy cells.

Additionally, the efficacy of tea saponin in inhibition of the proliferation and invasiveness of T-lymphoma (EL4) cells, may be also attributed to the effect of others inflammatory cytokines such as tumor necrosis factor alphaTNF-α in induced cancer cells death and NF-κB in controlled transcription of DNA, cytokine production and cell survival through mediated the regulation of MAPK pathway in transduction (process by which foreign DNA is introduced into a cell by a virus or viral vector) and extracellular signals to cellular responses in induction of cell proliferation, differentiation, development, transformation, and apoptosis.

Tumor necrosis factor alpha TNF-α, a pro-inflammatory cytokine plays an important role in the acute phase of inflammation with function in regulation of regulation of biological processes including cell proliferation, differentiation and apoptosis.



Nuclear factor-κB (NF-κB) is a transcription factor with function in regulated expression of genes involving many biological processes including innate and adaptive immunity, inflammation and stress responses,



In NOD/SCID mice transplanted intraperitoneally with human non-Hodgkin's lymphoma (NHL) cell lines Namalwa, RAP1-EIO and HS-Sultan, injection of green tea displayed a significant inhibition of
50% of Namalwa tumors and RAP1-EIO and HS-Sultan tumor through paralyzed tumor invasive activities.

In compared to chemotherapy drug cyclophosphamide, green tea exhibited anti-angiogenic effect in induction of.frequency of apoptotic endothelial and tumor cell and promoted tumor shrinking by blocking the formation of new blood vessels in providing nutrients and fluid for tumor expansion.


Base on the information findings, researchers opinionated, "Further trials in NHL to evaluate whether green tea, alone or in combination with chemotherapy, may delay or prevent disease progression".



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Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Immunomodulatory effect of tea saponin in immune T-cells and T-lymphoma cells via regulation of Th1, Th2 immune response and MAPK/ERK2 signaling pathway by Bhardwaj J1, Chaudhary N, Seo HJ, Kim MY, Shin TS, Kim JD.(PubMed)
(2) Inhibition of angiogenesis and induction of endothelial and tumor cell apoptosis by green tea in animal models of human high-grade non-Hodgkin's lymphoma by Bertolini F1, Fusetti L, Rabascio C, Cinieri S, Martinelli G, Pruneri G.(PubMed)

All About Green Tea: Green tea in in Ameliorated Risk and Treatment of Colon Cancer

Green tea with abundant polyphenol, may have a sustainable effect in reduced progression and treatment of colon cancer, some scientists suggested

Colon cancer is a medical condition caused by cell growth disorderly and uncontrollably in the colon tissues. At the later stage, the cancerous cell may travel a distance away to infect other healthy organs and tissues.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.

In the review of medical literature published online, green tea efficacy in reduced risk and treatment of colon cancer may be associated to the bioactive polyphenol EGCG expression in promoted and
decreased certain interaction in the cell profiles through various mechanisms.

According to the study by the University College of Medicine, Seoul, application of EGCG on HT-29 colon cancer cells showed a significant effect in inhibition of cell cycle progression of protein in COX-2 expression. through activation of AMPK activity in promoted metabolic tumor suppressor by regulating energy levels, enforcing metabolic checkpoints and inhibiting cell growth.

Cyclooxygenase(COX)-2, is an enzyme with function in speeding up the production of hormone prostaglandins in regulated cell proliferation and cell apoptosis.

AMPK(5' AMP-activated protein kinase) plays a role in cellular energy homeostasis, activation of AMPK may result in tumor growth inhibition, cell cycle arrest, and apoptosis of cancer cells in some tumor types/contexts.

Additionally, in inhibition of COX-2 expression green tea EGCG reduced prostaglandin E(2) secretion, thus reducing risk of Prostaglandin E2 (PGE2) in modulated angiogenesis, including the process of new blood vessel formation, promoted proliferation, migration and formation of endothelial cells, lining the interior surface of blood vessels and lymphatic vessels.


The study also emphasized that inhibiting AMPK by an AMPK inhibitor may interrupt the function of the bioactive compound in initiated such changes.


Continuously, the activation of enzyme AMPK also had a strong implication on VEGF (vascular endothelial growth factor) and glucose transporter in facilitated the transport of glucose over a plasma membrane and Glut-1 in facilitated the transport of glucose across the plasma membranes of mammalian cells in EGCG-treated cancer cells.

Further analysis, application of EGCG activated AMPK enzyme also modulated the production of ROS without causing ROS expression in initiated tumor progression and damage to cellular structures, such as the lipid membrane, protein and nucleic acid but inducing cancer cells DNA mutations and compromised genome integrity, subsequently in cancer cells senescence and death.


In other aspect of study of colon cancer in animal model, diminished levels of retinoid X receptor-alpha (RXRα) in regulated cancer cell growth and modulated suppress tumorigenesis may have a profound effect in cell proliferation.

Application of green tea bioactive EGCG expressed a significant effect in restored RXRα protein and expression levels caused by methylation function in alternated the activity of a DNA segment without changing the sequence, thus reducing risk of cancer expansion.

Additional differentiation also suggested that EGCG induced methylation changes in several other colon cancer related genes to restore the levels of RXRα without causing a decrease in global methylation in maintaining the epigenetic state of individual genes.

Change of globe methylation expression is found to associate to the occurrence of cancer.

Retinoid X receptor-alpha (RXRα) is a nuclear receptor with function in regulated cancer proliferation and modulated suppression of tumorigenesis.


Based the results finding, EGCG with a novel therapeutic effect on common and on chemo-resistant colon cancer cells may be considered as a secondary application used combination with chemotherapeutic agents, 5-FU for treatment of any types of colon cancer


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight


Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic
Impact In Rice, Pasta, And Potatoes In Half

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Apoptotic effect of EGCG in HT-29 colon cancer cells via AMPK signal pathway by Hwang JT1, Ha J, Park IJ, Lee SK, Baik HW, Kim YM, Park OJ.(PubMed)
(2) Reduction in promotor methylation utilizing EGCG (epigallocatechin-3-gallate) restores RXRα expression in human colon cancer cells by Morris J1, Moseley VR2, Cabang AB1, Coleman K2, Wei W3, Garrett-Mayer E4, Wargovich MJ1.(PubMed)
(3) Global Methylation in Exposure Biology and Translational Medical Science by Heather H. Nelson,1,2 Carmen J. Marsit,3,4 and Karl T. Kelsey4,5(PubMed)