All About Green Tea: Green Tea In in Ameliorated Hair Loss and Promoted Hair Re-Growth

Green tea may have a therapeutic and positive effect in reduced hair loss and stimulated hair growth, some scientists suggested.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.

Hair loss can be temporary or permanent but in most cases it is a result of the levels of by-product prolactin of testosterone of men increases, stimulating the production of the enzyme 5-alpha reductase that causes the conversion of testosterone to gihydro-testosterones DHT, leading to hair grow-back thinner or not grow-back at all, particularly in people with androgenic alopecia hair loss problem.

According to statistic, approximately 40% of men have noticeable hair loss by age 35, 65% by age 60, and 80% by age 80.


Green tea, bioactive polyphenolic compounds in attenuated hair loss were found to associate to several mechanisms, involved certain aspects.


The examine of green tea epigallocatechin-3-gallate (EGCG), a major constituent of polyphenol on human dermal papilla cells (DPCs) in the prevention or treatment of androgenetic alopecia showed that injection of the green tea extract express a strong effect in inhibition of 5alpha-reductase activity in conversion of testosterone to gihydro-testosterones DHT selectively in activated human dermal papilla cells (DPCs) in stimulated hair follicle growth.



Further analysis suggested that EGCG activity in enhanced growth of human dermal papilla cells (DPCs) was attributed to influence hair growth by dermal papilla cells proliferation through the activation of ERK pathways involved functions in regulation of cell cycle in division and Akt pathway in promoted cells survival and growth.




Additional observation also found that green tea extract also increased the ratio of Bcl-2/Bax which has been found to associate to lower dermal papilla cells apoptosis and stimulate hair follicle regrowth.




More interestingly, the evaluation of the effect of dihydrotestosterone (DHT) in induced androgenic alopecia by shortening the hair follicle growth phase, resulting in hair loss in animal models, application of green tea epigallocatechin gallate (EGCG) protected against dihydrotestosterone (DHT) in induction of mediated human dermal papilla cells (DPCs) death through cell cycle arrest, cell viability, the generation of reactive oxygen species (ROS), and senescence by inhibiting expression of alternated mRNA in human dermal papilla cells (DPCs) induced by dihydrotestosterone (DHT) activity, thus increasing the regrowth of hair follicle, subsequently, in stimulated hair to grow-back.



Dr. Shin S, the lead author of the study said, "EGCG ameliorates the negative effects of DHT by altering the miRNA expression profile in human DPCs".


Houttuynia cordata Thunb (HC), a traditional herbal medicine widely used in Asia for the treatment of patients with alopecia containing green tea (GT) as a major ingredient, in 25 days experiment of six-week-old male C57BL/6 mice randomly divided into four groups (negative control, finasteride (1 mg/kg),a positive control, and two group fed with 200 and 400 mg/kg concentrations expressed a strong effect of area of hair regrowth 70.2 % and 83.5 % respectively, in compared to of 55.1 % negative control group. And increased diameter of hair follicles was 11.9 μm, 17.4 μm and 22.8 (±5.2) μm also found in negative control, herbal complex 200 and 400 mg/kg group, respectively.

Further more, the application of herbal formula at the doses indicated also increased expression of insulin-like growth factor (IGF)-1 which has a direct implication on clinical improvement of hair growth and decreased expression of TGF-β1 alternated mRNA transcription activated by androgen in human dermal papilla cells (DPCs) to induce gradually hair loss.


Finally, on hair loss among rodents, 60 female Balb/black mice with hair loss on the head, neck and dorsal areas were assigned randomly assigned to group A fed with 50% fraction of polyphenol extract from dehydrated green tea in their drinking water for six months and Group B received regular drinking water, researchers after taking into account of other con founders, found that mice fed with green tea extract demonstrate a significant hair regrowth of 33% during six months of treatment in compared to no hair growth control.

Taken together, green tea with abundant bioactive polyphenols such as epigallocatechin-3-gallate (EGCG) may have a significantly clinical effect in promoted hair growth and ameliorated hair loss.
through many direct and indirect perspectives. Intake of green tea extract should be taken with special care as overdoses were found to induce acute liver toxicity in some reports.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Human hair growth enhancement in vitro by green tea epigallocatechin-3-gallate (EGCG) by Kwon OS1, Han JH, Yoo HG, Chung JH, Cho KH, Eun HC, Kim KH.(PubMed)
(2) Epigallocatechin Gallate-Mediated Alteration of the MicroRNA Expression Profile in 5α-Dihydrotestosterone-Treated Human Dermal Papilla Cells by Shin S1, Kim K1, Lee MJ1, Lee J1, Choi S1, Kim KS1, Ko JM1, Han H1, Kim SY1, Youn HJ2, Ahn KJ2, An IS3, An S1, Cha HJ1(PubMed)
(3) The effects of tea polyphenolic compounds on hair loss among rodents by Esfandiari A1, Kelley P.(PubMed)
(4) An Asian traditional herbal complex containing Houttuynia cordata Thunb, Perilla frutescens Var. acuta and green tea stimulates hair growth in mice by Chung MS1, Bae WJ2,3, Choi SW3, Lee KW3, Jeong HC3, Bashraheel F3, Jeon SH3, Jung JW1, Yoon BI1, Kwon EB2,4, Oh HA4, Hwang SY4, Kim SW5,6.(PubMed)

All About Green Tea: Green Tea In Reduced Weight Gain and Promoted Weight Loss

Green tea polyphenols may have a therapeutic effect in reduced weight gain through decreased hormone expression with function direct influence of excess energy deposit, some scientists opinionated.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.

Weight gain is an increase in body weight, involved an increase in muscle mass, fat deposits, excess fluids.


In the compared green tea, polyphenols [epigallocatechin gallate (EGCG), epigallocatechin (EGC)] in decoction of green tea leaves versus usual green tea extracts to evaluate the effect in weigh gain in obese animal models fed with high fat diet, researchers after taking into account of other con-founders suggested that green tea decoction acute administration of GTD with 2/3 EGCG+1/3 EGC inhibited SGLT-1 activity involved distinct and complementing glucose homeostasis through absorbing glucose from the diet in the small intestine and by reabsorbing the filtered glucose in the tubular system of the kidney, thus reducing access energy being converted to glycogen or fat and deposit in liver, muscles and fat cells.



Additionally, green tea decoction not only improved glucose tolerance but also demonstrated a significant increase GLUT2 protein in facilitated glucose movement across cell membranes in the regulation of glucose absorption in distribution of dietary sugar to tissues to induce calorie restriction.



Chronic administration of green tea decoction GTD for 6 weeks, in the same experiment models also displayed a huge reduction of body weight gain, circulating triglycerides and cholesterol and improved glucose tolerance, through significantly reduced SGLT-1 as seen in acute application and and increased GLUT2 mRNA levels in the jejunum mucosa with function in increase the surface area of tissue available to absorb nutrients from ingested foodstuffs for decreased fat accumulation and glucose in liver.


Dr. Snoussi C, the lead auhtor said, "GTD-treated rats for 6 weeks display significantly reduced SGLT-1 and increased GLUT2 mRNA levels in the jejunum mucosa". This result showed that green tea decoction with polyphenols such as epigallocatechin gallate (EGCG), epigallocatechin (EGC) may have a certain effect in reduced weight gain through decreased fat deposit in the liver and promoted calorie restriction.

Further analysis of C57BL/6J mice fed a high-fat/high-sucrose diet (HF/HS, 32% energy from fat; 25% energy from sucrose) or the same diet supplemented with 0.25% GTP or BTP or a low-fat/high-sucrose (LF/HS, 10.6% energy from fat, 25% energy from sucrose) diet for 4 weeks showed that treatment with decaffeinated green tea (GT) polyphenols inhibited weight gain in mice fed an obesogenic diet as indicated above, through the rearrange the relative proportions of Blautia, Bryantella, Collinsella, Lactobacillus, Marvinbryantia, Turicibacter, Barnesiella, and Parabacteroides in correlated with weight loss by a decrease of cecum Firmicutes and increase in Bacteroidetes in the gastrointestinal tract.
In deed, GTP not only induced weight loss in association with alteration of the gut microbiota but also increased hepatic AMPK in reaction in sugar metabolism, and energy storage and release.


Interestingly, according to the START Clinic for the Mood and Anxiety Disorders, oral administration of green tea extract induced an unexpected decrease in total body fat mass, a decrease in body fat percentage and an increase in lean body mass in patients with weight gain induced by psychotropic medications.


Taken together, green tea, bioactive active polyphenols epigallocatechin gallate (EGCG), epigallocatechin (EGC) may be used as functional food in reduced weight gain induced by all sources and increased weigh loss through regulation of energy metabolism in fat accumulation.


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Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Decaffeinated green and black tea polyphenols decrease weight gain and alter microbiome populations and function in diet-induced obese mice by Henning SM1, Yang J2, Hsu M2, Lee RP2, Grojean EM2, Ly A2, Tseng CH3, Heber D2, Li Z2.(PubMed)
(2) Green tea decoction improves glucose tolerance and reduces weight gain of rats fed normal and high-fat diet by Snoussi C1, Ducroc R2, Hamdaoui MH3, Dhaouadi K4, Abaidi H3, Cluzeaud F2, Nazaret C2, Le Gall M2, Bado A5.(PubMed)
(3) Weight gain and psychiatric treatment: Is there a role for green tea and conjugated linoleic acid? by Katzman MA1, Jacobs L, Marcus M, Vermani M, Logan AC.(PubMed)

All About Green Tea: Green Tea In Reduced Risk and Progression and Treatment of Kidney Cancer

Green tea may have a substantial and sustainable effect in reduced risk and treatment of renal cancer, some scientists suggested.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.

Kidney cancer is medical condition characterized by irregular cell growth in the issues of kidney. At the later stage, the cancerous cell may travel a distance away to invade other healthy tissues and organs.

According to statistic, kidney cancer is very uncommon in people younger than age 45 and among the 10 most common cancers in both gender.

Investigation of green tea effect in risk of renal cancer was found to associate to different implications involved numbers of mechanisms, particularly, in green tea bioactive components.

According to the evaluated 250 newly diagnosed, histo-logically confirmed Clear cell renal cell carcinoma (CCRCC) cases and 299 sex-, age-matched healthy controls provided complete information by face-to-face interview in Shanghai between 2007 and 2009, application of green tea at dose of ≥500 ml/d demonstrated a significantly inverse association to risk of CCRCC.



In deed, green tea consumption of lower than the said volume such as 8 oz (237 ml) or more cups/day was also associated to decrease renal cell cancer risk, in compared to non drinkers, according to the report of Brigham and Women's Hospital and Harvard Medical School.

Further analysis also found that interactions with the environmental exposures association to polymorphisms of the xenobiotic-metabolizing enzymes in induced CCRCC risk, also inhibited by green tea extract through increasing serum and liver antioxidant capacity and strengthening stability of microsomal and lysosomal membranes of healthy cells in compared to control.


In free radical aspect, the examine Wistar rats induced renal cancer pre-treated with N-ethyl-N-hydroxyethylnitrosamine (EHEN) by oral injection of drinking water for 2 weeks, also found that administration of green tea extract catechin ( 0.1% polyphenon-60) over 30 weeks of period of treatment exhibits a significant effect in decreased the incidence of renal cell tumors greater than 3 mm in diameter but not tumors that are less than 3 mm in diameter, through over expression of antioxidant in suppression of reactive oxygen species (ROS) induced by N-ethyl-N-hydroxyethylnitrosamine (EHEN) pre-treatment.




Importantly, in alternated gene expression in increased prevalence of cancer in human subjects,
application of green tea polyphenol, catechins have been reported to reverse change of DNA methylation in contributed to the tumor repressive gene of RGS2 (regulator of G-protein signaling 2) in modulated expression of cancers and increased the regulation of conversion of DNA to RNA (transcription) of these genes in ameliorated risk of renal and other cancer(s).


Further more, application of the combination of green tea extract bioactive catechins and epigallocatechin gallate also showed to modulate DNA methylation by attenuating the effect of DNA methyltransferase 1 (DNMT1) to ensure the fidelity of replication of inherited epigenetic patterns.

Aberrant DNA methylation patterns are associated with increased prevalence of renal and other tumor(s).

Taken together, Green Tea and its polyphenols bioactive compound catechins and epigallocatechin gallate may have a potential and therapeutic effect in reduced risk and treatment of renal cancer through antioxidants and anti gene alternative activities.


Pregnancy Miracle
Reverse Infertility And Get Pregnant Naturally
Using Holistic Ancient Chinese Medicine


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Risk factor for clear cell renal cell carcinoma in Chinese population: a case-control study by Wang G1, Hou J, Ma L, Xie J, Yin J, Xu D, Chang W, Tan X, Su T, Zhang H, Cao G.(PubMed)
(2) [Effects of green tea extract and its components on antioxidant status and activities of xenobiotic metabolizing enzymes of rats] by [Article in Russian](PubMed)
Kravchenko LV, Trusov NV, Aksenov IV, Avren'eva LI, Guseva GV, Lashneva NV, Tutel'ian VA.
(3) Intakes of coffee, tea, milk, soda and juice and renal cell cancer in a pooled analysis of 13 prospective studies byLee JE1, Hunter DJ, Spiegelman D, Adami HO, Bernstein L, van den Brandt PA, Buring JE, Cho E, English D, Folsom AR, Freudenheim JL, Gile GG, Giovannucci E, Horn-Ross PL, Leitzmann M, Marshall JR, Männistö S, McCullough ML, Miller AB, Parker AS, Pietinen P, Rod riguez C, Rohan TE, Schatzkin A, Schouten LJ, Willett WC, Wolk A, Zhang SM, Smith-Warner SA.(PubMed)
(4) Effect of polyphenon-60 on the development of renal cell tumors in rats treated with N-ethyl-N hydroxyethylnitrosamine byYoshioka N1, Hiasa Y, Cho M, Kitahori Y, Hirao K, Konishi N, Kuwashima S.(PubMed)
(5) Targeting DNA Methylation with Green Tea Catechins by Yiannakopoulou E.C.(Karger)

All About Green Tea: Green Tea In Reduced Risk, Progression and Treatment of and Neuro-Degenerative Diseases

Green tea is found to consist a substantial and respectful effect in reduced risk, progression and treatment of neuro-degenerative diseases, some scientists opinionated.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.

Neuro degenerative diseases are a class of conditions characterized by deteriorating neurons and accumulated plaque in blocking the neuro transmitters of the brain and spinal cords in performance of normal functions.

According to the statistic, approximately, 5 million Americans suffer from Alzheimer's disease, 1 million from Parkinson's and 400,000 from multiple sclerosis (MS) today, inducing overwhelming social, economic and health care burden on society.



The differentiation of green tea bioactive constituents in risk of neuro-degenerative diseases was found to associate to numbers of mechanism through many different aspects.


The investigation of green tea bioactive epigallocatechin-gallate (EGCG) activities in lipopolysaccharide- (LPS-) mediated systemic inflammation in induction of neurodegenerative diseases suggested that application of green tea chemical constituent demonstrated a significant effect in ameliorated LPS induced expression of proinflammatory cytokines of tumor necrosis factor alphaTNF-α, a cell signalling protein involved in systemic inflammation in the acute phase of infection, and interleukin 1 beta (IL1β), an cytokine with function in the regulation of immune and inflammatory responses to infections or sterile insults and interleukin 6 (IL-6) involved in inflammation and infection responses, particularly, in the inhibition of the expressions of inflammatory cytokines in the mononuclear blood cells (PBMCs), consisting lymphocytes (T cells, B cells, NK cells) with function to clear away of debris in the infection site.

The activation of inflammatory cytokines expression caused by lipopolysaccharide- (LPS) injection can trigger neurotoxicity, leading to neurons brains progressive degeneration, resulting in elevated risk of neuro degenerative diseases.

Application of green tea bioactive epigallocatechin-gallate (EGCG) was found not only inhibited LPS in precipitation of toxicity in resolved inflammation and mediated neuroprotection but also exerted anti toxicity through its antioxidant activity in decreased expression of reactive oxygen species in triggered brain cell apoptosis.


Interleukin 6 (IL-6) acts as both pro-inflammatory cytokines and an anti-inflammatory mytokines with function involved inflammation responses at sites of acute and chronic infection.

Further analysis of green tea Epigallo-catechin-3-gallate (EGCG) in the aspect of ROS in risk of neuro-degeneration in the dentate gyrus, part of the hippocampus and/or hippocampal formation of C57Bl/6 mice, suggested that the application promoted neural precursor cell, (a partially differentiated cell) proliferation, without changes at the level of immature and mature new neurons.



Interestingly, in adult hippocampal neurogenesis in male Balb/C mice, injection of green tea bioactive compounds in different doses also expressed a strong implication of increased cells survival without affecting cell proliferation but decreasing apoptotic cells.



The increased production of neuro precursor cell in stimulated neuro generation and increased cell survival from green tea was attributed to the green tea antioxidants acted as free radical scavengers to ameliorate chain reaction stimulated by reactive oxygen species (ROS).



Further more, green tea treatment was found to promote production of more elaborated dendritic (structures on the neuron that receive electrical messages) trees in young DCX-positive neurons with function in acquisition of spatial learning, as well as reversal learning, but not the retrieval of stored long-term memories.




Implication of green tea bio compounds EGCG also significantly increased net growth and development of nervous tissue in the adult hippocampus and hippocampal levels of phospho-Akt.in regulated multiple cellular processes, including glucose metabolism, apoptosis, cell proliferation, transcription and cell migration by re-establishing the function of PI3K in intracellular signaling pathway.

Dr. Neha Atulkumar Singh, the lead author in the article of "Potential neuroprotective properties of epigallocatechin-3-gallate (EGCG)",said, "there is a need to identify a class of drug capable of reversing neural damage and preventing further neural death" and "assesses the reliability of the neuroprotective benefits of epigallocatechin-gallate (EGCG) by shedding light on their biological, pharmacological, antioxidant and metal chelation properties, with emphasis on their ability to invoke a range of cellular mechanisms in the brain".


Taken together, green bioactive compound, EGCG may represent a potent and useful neuroprotective agent for inflammation-mediated neurological disorders and be considered as useful principle in modulated brain plasticity.



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(2) Potential neuroprotective properties of epigallocatechin-3-gallate (EGCG).
Singh NA1, Mandal AK2, Khan ZA3.(PubMed)
(*) Neuroprotective Activity of (-)-Epigallocatechin Gallate against Lipopolysaccharide-Mediated Cytotoxicity by Liu JB1, Zhou L1, Wang YZ2, Wang X2, Zhou Y2, Ho WZ3, Li JL2.(PubMed)
(*) Green tea compound epigallo-catechin-3-gallate (EGCG) increases neuronal survival in adult hippocampal neurogenesis in vivo and in vitro by Ortiz-López L1, Márquez-Valadez B2, Gómez-Sánchez A1, Silva-Lucero MD3, Torres-Pérez M1, Téllez-Ballesteros RI1, Ichwan M4, Meraz-Ríos MA5, Kempermann G6, Ramírez-Rodríguez GB7.(PubMed)

All About Green Tea: Green Tea In Protection and Treatment of Retinal Degenerative Disease

Green tea phenolic content may have a sustainable and therapeutic effect in reduced risk and progression of retinal degeneration, some scientists suggested.



Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.


Retinal degeneration is a macular disease characterized by impaired vision, night blindness, retinal detachment, light sensitivity, tunnel vision, and loss of peripheral vision to total loss of vision.


The evaluation of green tea effect in risk of retinal degeneration was found to be implicated by several mechanisms through numbers of aspects.


In ROS implication of oxidative stress-induced degeneration of the retina occurred in age-related macular degeneration (AMD) and glaucoma, application of green tea polyphenols epigallocatechin gallate (EGCG) exhibited antioxidant effect as free radical scavenger in ameliorated chain reaction of ROS in causing loss of neuron with direct effects of retinal function and reduced cytotoxicy of free radicals in induction of retinal cellular apoptosis.

Administration of green tea phynolic compound exerted 10 times more effective in treatment of retinal degeneration, in compared to potent medicine trolox (vitamin E analogue) in attenuating lipid peroxidation caused by the nitric oxide donor, sodium nitroprusside (SNP), according to the study.


Particularly, green tea epigallocatechin gallate (EGCG) inhibited a significant decrease in photoreceptor-specific markers (RET-P1, rhodopsin kinase) which may be an indication of photoreceptor cells in the transition to degenerate prematurely, eventually resulting in blindness and an increase in the cell death marker caspase-3 caused by oxidative stress induced by injection of sodium nitroprusside (SNP)


According to the observation by Western blotting techniques, SNP was completely inhibited by EGCG injection in ameliorated the detrimental effects to the retina caused by SNP.
Dr. Zhang B, the co-author said, "Since oxidative stress has been implicated in retinal diseases like AMD and glaucoma this study provides "proof of principle" for the idea that daily intake of EGCG may help individuals suffering from retinal diseases where oxidative stress is implicated".


More interestingly, in BALB/cJ mice treated with either EGCG or saline via intraperitoneal (IP) injection, and then placed under constant cool white light-emitting diode (LED) light (10,000 lux) for 5 h, EGCG treatment group showed a strong protective effect on the retina against light damage (LD) in compared to the control group.



According to the optical coherence tomography (OCT) and and electroretinography (ERG), in the examine the retinal structure and function after LD indicated that application of green tea EGCG improved significantly higher ERG amplitudes for all three wave types through inducing morphologic protection of photoreceptors also in compared to control.



Moreover, the green tea extract bio-compound also decreased oxidative stress through increase the mRNA level of the antioxidant expression of Sod2, a manganese-dependent superoxide dismutase (MnSOD) before LD and 24 h after LD.

Dr. Qi S1,, the lead author said, "The IP injection of EGCG attenuated the detrimental effects of bright light on the retinas of BALB/cJ mice by protecting the structure and function of the retina".



Importantly, in study to evaluate green tea EGCG effect in reduced glutamate induced excitotoxicity in the retina, researchers conducted a study of female Wistar rats (n = 171) randomly signed into a normal control group (n = 9); saline control group with intravitreal saline injections (n = 54); NMDA control group with an intravitreal NMDA injection and intraperitoneal saline injections (n = 54); and NMDA study group (n = 54) receiving an intravitreal NMDA injection plus intraperitoneal EGCG (25 mg/kg) injections, observation of the groups at 2 weeks after additional injection of NMDA showed that group with treatment of intraperitoneal application of EGCG reduced a significantly less marked NMDA-associated loss of retinal ganglion cell, through inhibition of decreasing retinal ganglion cell layer (GCL), neurons located near the inner surface (the ganglion cell layer) of the retina of the eye in received visual information from photoreceptors via cell density and thickness of Thy-1 immunoreactivity in several areas of the immature and adult human brain in expression of retinal ganglion cell damage.


Taken together, there is no doubt that Epigallocatechin-3-gallate (EGCG), a major polyphenol of green tea, may be considered as secondary therapeutic treatment used combination with standard therapy for protection and treatment of retinal degenerative disease



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299Sources

(1) Oxidative-induced retinal degeneration is attenuated by epigallocatechin gallate by Zhang B1, Osborne NN(PubMed)
(2) Neuroprotective effect of epigallocatechin-3-gallate against N-methyl-D-aspartate-induced excitotoxicity in the adult rat retina by Chen F1, Jiang L, Shen C, Wan H, Xu L, Wang N, Jonas JB(PubMed)
(3) Intraperitoneal injection of (-)-Epigallocatechin-3-gallate protects against light-induced photoreceptor degeneration in the mouse retina by Qi S1,2, Wang C1,2, Song D2, Song Y2, Dunaief JL2.(PubMed)--

All About Green Tea: Green Tea Catechins In reduced Risk and Treatment of Pancreatic Cancer

Green tea may have a therapeutic and positive effect in reduced risk and treatment of pancreatic cancer, some scientists suggested.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.

Pancreatic cancer is medical condition characterized by irregular cell growth in the issues of pancreas. At the later stage, the cancerous cell may travel a distance away to invade other healthy tissues and organs.

According to statistic, the average lifetime risk of pancreatic cancer for both men and women is about 1 in 65.



In the analysis of medical literature published online, green tea catechins, epigallocatechin gallate (EGCG) effect in reduced risk and treatment of pancreatic cancer was attributed to the contributions of various mechanisms.


In human pancreatic ductal adenocarcinoma (PDAC) cell lines PancTu-I, Panc1, Panc89 and BxPC3, to compare the inhibited effect of EGCG to 2 components of catechins, namely, catechin gallate (CG) and epicatechin gallate (ECG), application of green tea 2 catechins components demonstrated a strong effect in inhibited proliferation of PDAC cells in a dose- and time-dependent manner.
In comparison test, green tea CG and ECG exerted much stronger anti-proliferation effects than those of EGCG.



The proliferation of PancTu-I cells retained by green tea catechin was attributed to the antioxidant effect in interference of the cancer cell division cycle through mediating the cytokines in modulation of cell cycle regulatory proteins, such as cyclins, a cell division regulators, cyclin-dependent kinase (Cdk) enzymes activated by cyclins in regulated cell progression through cell cycle arrest, and CDK inhibitors with function in prevented over proliferation of cancer cells.
Additionally, all 3 components of green tea catechins also demonstrated a substantiated effect in ameliorated secretion of pro-inflammatory and invasion promoting proteins of the cancer cell through expression of TNF tumor necrosis factor in activated of the nuclear factor NF-κB protein signalling involved mediation of DNA transcript, pro inflammatory cytokines production and cancer cell survival.

Tumor necrosis factor is a cell signaling protein possessed a wide range of proinflammatory actions

NF-κB is a protein with function in controlled transcription of DNA, cytokine production and cell survival.


Further analysis once again found that green tea catechins ECG and CG exhibit potent and much stronger anti-proliferate and anti-inflammatory activities on PDAC cells in compared to EGCG




In human pancreatic cancer cells lines MIA PaCa-2 cells, injection of green tea EGCG plus Bleomycin, (BLM), an anti-cancer chemotherapeutic drug displayed a substantial effect in inhibited cell proliferation through cell cycle transition phase arrest and mitochondrial depolarization by mitochondrial permeability transition in induction of cell apoptosis, after 72 hours.

Additional examination, indicate that EGCG and BLM exhibited anti-proliferative effects significantly in induced apoptosis of MIA PaCa-2 cells and suggested that this combination could represent a new strategy with potential advantages for treatment of pancreatic cancer.
In pancreatic cancer cell lines MIA PaCa-2 and PANC-1, injection of pterostilbene isolated from blue berry and EGCG expressed a strongly additive antiproliferative effect after 72 hours with MIA underwent S-phase arrest but not in cancer cell line PANC-1.


Both pterostilbene and EGCG induced mitochondrial depolarization in enhanced cytochrome c released from mitochondria to trigger programmed cell death during the early stages of apoptosis was observed also in MIA, but not in PANC



EGCG increased caspase-3/7 function in induced cell apoptosis in MIA but the combined treatment did not significantly increase the activity in either cell lines. these contradictory activities may indicate that cell death occurs in MIA, possibly through another mechanism.

Taking altogether, green tea with abundant antioxidant catechins may be used as adjunct therapy for reduced risk and combined standard medicine for treatment of pancreatic cancer.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Epicatechin gallate and catechin gallate are superior to epigallocatechin gallate in growth suppression and anti-inflammatory activities in pancreatic tumor cells. by Kürbitz C1, Heise D, Redmer T, Goumas F, Arlt A, Lemke J, Rimbach G, Kalthoff H, Trauzold A.(PubMed)
(2) Inhibitory effect of (-)-epigallocatechin-3-gallate and bleomycin on human pancreatic cancerMiaPaca-2 cell growth by Bimonte S#1, Leongito M#1, Barbieri A2, Del Vecchio V2, Barbieri M1, Albino V1, Piccirillo M1, Amore A1, Di Giacomo R1, Nasto A1, Granata V3, Petrillo A3, Arra C2, Izzo F1.(PubMed)
(3) Inhibitory effects of (-)-epigallocatechin-3-gallate and pterostilbene on pancreatic cancer growth in vitro by Kostin SF1, McDonald DE, McFadden DW.(PubMed)

All About Green Tea: Green Tea in Attenuated Risk and Treatment of Autoimmune Diseases

Green tea bioactive Epigallocatechin-3-gallate (EGCG) may have a therapeutic and profound effect in attenuated risk and treatment of autoimmune diseases, some scientists postulated.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.

Autoimmune diseases are class of diseases characterized by immune system in attacking its own tissues.

Green tea bioactive compound Epigallocatechin-3-gallate (EGCG) in risk of autoimmune diseases was found to associate to many different mechanisms involved numbers of aspect.

In interleukin-1 receptor antagonist knockout (IL-1raKO) arthritis rodent models of human rheumatoid arthritis, intraperitoneal injection of EGCG three times per week after the first immunization showed a significant reduction of arthritis index observed by decreased damage and destruction of joint tissues.

The efficacy of green tea phytochemicals in inhibited arthritis expression was attributed to the activities in reduced production of pro-inflammatory cytokines in accumulation of inflammatory cells into the synovium for joint destruction and oxidative stress proteins in facilitated inflammation and destruction of the joints in arthritis.


Furthermore, the extract also exhibited anti STAT3 expression in mediated variety of genes in response to cell stimuli to induce cellular processes such as cell growth and division, cell movement, and apoptosis activated by cytokine-dependent inflammation, through phosphorylation-Stat3 Antibody (y705) and (S727)in shortening the duration of STAT3 activity.
Interestingly, additional analysis also found that application of green tea bioactive compound lowers the mediation effect of mammalian target of rapamycin (mTOR) function in limited production of pro inflammatory cytokines and hypoxia-inducible factor 1 (HIF-1) in regulation of vascular endothelial growth factor (VEGF) function in activated pro inflammatory expression in innate immunity.


Moreover, injection of EGCG also exhibited anti-osteoclastic activity observed by reduced osteoclast markers in EGCG-treated IL-1RaKO mice.

In mice induced Sjögren's syndrome with pathogenic effects of reactive oxygen species (ROS) in the salivary glands, administration of green tea Epigallocatechin gallate (EGCG), was found to reduce over expression of ROS in precipitated oxidative stress-induced DNA damage and apoptosis in MRL-Fas(lpr) mice with autoimmune sialadenitis through Heme oxygenase(HO)-1 in response to pro antioxidant expression and Bcl-2 with function to induce cell survival.

Additionally, in the investigation of the ameliorated effects of green tea in risk of autoimmune sialadenitis in a murine model, application of the green tea extract chemical compound decreased severity of sialadenitis substantially through reduced expressions of Thymine glycol (5,6-dihydroxy-5,6-dihydrothymine) with function in induced DNA damage.by oxidation and ionizing radiation andgp91phox subunit of NADPH oxidase in production of ROS to react to the acute phase of infection.


Further differentiation indicated that the chemical constituents also ameliorated single-stranded DNA (ssDNA) function in DNA duplication in both viruses and organisms and cleaved caspase 3 activity in mediation of programmed cell death and TP53 or tumor protein in regulated apoptosis mediated by expression of BAX.



More profoundly, in the examine duct epithelial cells of salivary glands, EGCG-treated mice showed decreased levels of SS-A/Ro, an extractable nuclear antigen (ENA) and Sjögren syndrome antigen B or Lupus La protein (SSB/La) associated with auto immune diseases such as systemic lupus erythematosus (SLE) and Sjögren's syndrome (SS).

Finally, green tea EGCG-treated mice also showed a lower Ifi202b interferon activated gene 202B expression in implicated the development of systemic lupus erythematosus (SLE) and Ifi202 over expression in the kidney and immune organs, an indication of significantly increased disease progression in autoimmune glomerulonephritis, according to publication of Gene ID: 26388, updated on 5-Nov-2017.

Taken together, green tea processed abundantly bioactive phytochemicals may be considered as a functional food in reduced risk and treatment of auto immune diseases. Intake of green tea extract should be taken with care as overdose-toxicity has been reported in numbers of incidence.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(*) Epigallocatechin gallate inhibits oxidative stress-induced DNA damage and apoptosis in MRL-Fas(lpr) mice with autoimmune sialadenitis via upregulation of heme oxygenase-1 and Bcl-2. by Saito K1, Mori S, Date F, Ono M.(PubMed)
(*) EGCG attenuates autoimmune arthritis by inhibition of STAT3 and HIF-1α with Th17/Treg control by Yang EJ1, Lee J2, Lee SY1, Kim EK1, Moon YM1, Jung YO3, Park SH2, Cho ML1.(PubMed)
(*) Green tea EGCG, T cells, and T cell-mediated autoimmune diseases by Wu D1, Wang J, Pae M, Meydani SN.(PubMed)
(*) The ability of green tea to alleviate autoimmune diseases: fact or fiction? by Wu D, Wang J.