All About Green Tea: Green Tea in Reduced Risk, Progression and Treatment of Oral Cancer

Green tea may have a profound and sustainable effect in reduced risk and treatment of oral cancer, some scientists suggested.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory. Adding a slice of ginger will neutralize the risk.

Oral cancer is medical condition characterized by irregular cell growth in the issues of mouth area. At the later stage, the cancerous cell may travel a distance away to invade other healthy tissues and organs.

According to statistic, 1 in 75 men and 1 in 150 women will be diagnosed with oral cancer during their lifetime


In the review of medical literature online, green tea extract green tea catechin, (-)-epigallocatechin-3-gallate (EGCG) showed to reduced risk and treatment of oral cancers through some particular mechanisms.

In human oral squamous carcinoma cells (SCC-25, SCC-9), application of green tea catechin, (-)-epigallocatechin-3-gallate (EGCG) suppressed SIRT3 mRNA and protein expression in induction of SCC-25 cells proliferation, through antioxidant effect in attenuated function of SIRT3 in contribution to cancer cell survival via mRNA transmitting by modulating oxidative stress..


Some reserachers also insisted that SIRT 3 may be considered as a bio-maker for targeting stage and grade of cancer progression.


Further analysis, suggested that green tea bioactive EGCG also up regulated the nuclear localization of the estrogen-related receptor α (ERRα) in inhibited oral cell carcinoma tumors by regulating SIRT3 in expression of cancer cellular metabolism.


Interestingly, EGCG application also displayed a significant effect in modulated the mRNA expressions of SIRT3-associated to cancer cell in induction of cell proliferation through inhibiting the production of reactive oxidative species in precipitated chain reactive in initiation of cancer cell division.

More importantly, in ROS perspective, oral administration of green tea EGCG by targeting the protein SIRT3 in exhibited antioxidant effect in protect healthy cells without affecting formation of ROS to facilitate oral cancer cell apoptosis through cytotoxicity.


Dr. Tao L, after taking into account of other cofounders, said, "SIRT3 represents a novel potential target through which EGCG exerts differential prooxidant effects in cancer and normal cells".

Further observation of the efficacy of green tea extract EGCG, also indicated that EGCG treatment increased the production of mitochondrial H2O2 in SCC-25 cells within 6 hours before inducing cancer cells apoptosis.


In antioxidant activity. green extract EGCG induced differential expression of genes related to antioxidant defense in oral cancer cell and gingival fibroblasts, which are critical in sustaining inflammation in periodontal disease through ameliorated expression of metallothionein 3 in induction of degeneration of cells and superoxide dismutase 2/3, and thioredoxin reductase 2 in facilitate oxidative stress to induce oncogenesis without increased cell proliferation of human gingival fibroblast -1 (HGF-1).

Additional examination indicated that the application also exhibited anti oral cancer apoptosis by increased expression of mitochondrial ROS and mitochondrial dysfunction in facilitated intoxicate effect without causing harm to the gingival fibroblasts through antioxidant selective activities.


Green tea with promising chemo properties due to their decreased dose and limited toxicity profiles, Dr. Ramshankar V1, the lead author said, "It is worthwhile to include green tea extract in an oral screening program for evaluating the pre-malignant lesions comparing the results between the treated and untreated group. Given the wide acceptance of green tea, its benefits may help in effective chemo-prevention oral cancer".


Taken together, green tea with abundant bioactive polyphennols may be considered as a function for prevention and used as adjunct therapy in combination with standard treatment of oral cancer. Intake of green tea extract as supplement are not recommended as toxicity has been reported in numbers of case.

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Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Differential prooxidative effects of the green tea polyphenol, (-)-epigallocatechin-3-gallate, in normal and oral cancer cells are related to differences in sirtuin 3 signaling by Tao L1, Park JY, Lambert JD.(PubMed)
(2) The role of the mitochondrial oxidative stress in the cytotoxic effects of the green tea catechin, (-)-epigallocatechin-3-gallate, in oral cells.by Tao L1, Forester SC, Lambert JD.(PubMed)
(3) Chemoprevention of oral cancer: Green tea experience by Ramshankar V1, Krishnamurthy A2.(PubMed)

All About Green Tea: Green Tea In Attenuated Risk, Progression and Treatment of Skin Cancer

Green tea may have a strong and positive effect in reduced risk and treatment of skin cancer, some scientists suggested.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.

Skin cancer is medical condition characterized by irregular cell growth in the issues of skin. At the later stage, the cancerous cell may travel a distance away to invade other healthy tissues and organs.

According to statistic, approximately, 87,110 new cases of invasive melanoma are diagnosed in the U.S every years

The evaluation of green tea effect in overexposure to environmental solar ultraviolet (UV) radiation (290-400 nm) which has been found to increase risk of the development of melanoma and non-melanoma skin cancers in mice model showed that oral administration of green tea pylophenols (GTPs) in drinking water or the topical application of EGCG prevents UVB-induced skin tumor development in tested subjects.

Particularly, (-)-Epigallocatechin-3-gallate (EGCG), the major and most photoprotective polyphenolic component of green tea also exhibited a protective activity against UV in induction of skin cancer, through induction of immunoregulatory cytokine interleukin (IL) 12 in differentiation of naive T cells into Th1 cells and acted as T cell-stimulating factor in stimulate the growth and function of T cells.

Moreover, interleukin (IL) 12 also demonstrated a significant effect as an antagonist against immunosuppression induced by solar/ultraviolet (UV) radiation by restoring immune responses and also stimulating DNA repair.



Further analysis also indicated that green tea (-)-Epigallocatechin-3-gallate (EGCG) also inhibited UV in induction of skin tumors; angiogenetic effect in stimulated production of new blood vessels to
provide nutrients and oxygen for cancer cells proliferation and survivals and initiated cytotoxic T lymphocyte cells in induced cancer and infectious and damage cells apoptosis.


Interestingly, additional study of green tea polyphenols (GTPs) in prevention of UVB irradiated (80 mJ/cm(2)) 3 times each week for 24 wk in induced skin cancer in mice divided in to group consumed water and group fed with water containing 2 g/L GTPs, showed that group treated with GTPs displayed a significant reduced UVB-induced tumor incidence by 35%, tumor multiplicity by 63%, and tumor growth by 55% in compared to non treatment group.

Group treated with GTPs+UVB also demonstrated a reduced expression of the matrix metalloproteinases (MMP)-2 and MMP-9, which are activator associated with progression from benign to advanced cancer and enhanced expression of specific endogenous tissue inhibitors of metalloproteinases (TIMPs), tissues inhibitor of MMP in skin tumors in compared to mice treated with UVB alone.

Further more, GTPs+UVB group also reduced expressions of CD31 and vascular endothelial growth factor, in activated development of new blood vessel to nourish skin tumor cells proliferation and site expansion and inhibited expression of proliferating cell nuclear antigen, a key factor in DNA replication and cell cycle regulation in skin cancer in compared to UVB group.

More importantly, mice treated with GTPs+UVB group also showed more cytotoxic CD8(+) T cells in the tumors in compared to UVB group by exhibited greater activation of caspase-3 epression in induced apoptosis of the tumor cells.

The information findings suggested a potential and therapeutic effect of green tea and its bioactive polyphenols (GTPs) in attenuated risk, progression and treatment of melanoma and non-melanoma skin cancers.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

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Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Green Tea Prevents Skin Cancer by Two Mechanisms by Navid Bouzari, Yvonne Romagosa, Robert S. Kirsner(PubMed)
(2) Green tea and skin cancer: photoimmunology, angiogenesis and DNA repair by Katiyar S1, Elmets CA, Katiyar SK.(PubMed)
(3) Orally administered green tea polyphenols prevent ultraviolet radiation-induced skin cancer in mice through activation of cytotoxic T cells and inhibition of angiogenesis in tumors by Mantena SK1, Meeran SM, Elmets CA, Katiyar SK.(PubMed)

All About Green Tea: Green Tea In Protection Against Chronological and Photo Aging

Although no one can avoid aging, the process can be slow down. Green tea may have a potential and positive effect in delay the process through its anti aging phytochemicals, some scientists suggested.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.

The investigation of green tea properties in anti aging effect was found to associate many different mechanisms involved expression of some major polyphenols.

According to the investigation of the experiment of 45 male mice model divided into 5 groups induced aging through injection of d-galactose in the period of 8 weeks in compared to positive control fed with Vitamin C (VitC), mice treated with green tea, bioactive Epigallocatechin gallate(EGCG) once a day by subcutaneously inject after 5h of injecting d-galactose exerted a antioxidant effect in improved over all skin condition and whole structure of skin in compared to positive control at the end of study.


Further analysis also found that the chemical constituents of green tea inhibited the over production of osidative stress caused by injection of d-galactose through neutralized ROS insults to maintain good dermal health.


Interestingly, in compared to control, green tea EGCG also increased expression of epidermal growth factor in stimulated skin growth at the cellular level and increase collagen production in protect skin against aging senility.



Moreover, the evaluated characteristics of human skin and how photo-aging (extrinsic aging) occur via the impact of ROS production by cascade signaling pathways indicated that administration of green tea extracts (GTEs) protects the affect of aging skin through inhibited cutaneous erythema induced of redness of the skin, thickening of the epidermis involved over expression of CK5/6 in promoted cutaneous neoplasms, a new and abnormal growth of skin tissue and cytokeratin(CK16) in induction of expression in abnormal skin epithelial patterns.

In deed, the expression green tea also showed a strong implication in reduced matrix metalloproteinases 2-9 (MMP-2, MMP-9) activities in elevated skin changes and depletion of CD1a(+) LCs in induction of skin inflammation, caused by UVR application



In chronological (intrinsic) aging, administration of polyphenols, which are secondary plant metabolites also found to protect against skin aging through exhibition of antioxidant and anti-inflammatory effects, according to the existing literature, linking skin aging and the ability of polyphenols as regulatory elements with function in maintained skin homeostasis.




Dr. Davinelli S, said at end of study, "Polyphenols exert their influence mostly through their antioxidant and anti-inflammatory effects, thereby abrogating collagen degradation and/or increasing procollagen synthesis".




Finally, in the 33 healthy Asian subjects, all men enrolled after consent in a placebo-controlled comparative study with a split face design with one group applied multiple emulsions with green tea and the second group applied multiple emulsions with lotus extract, while a third group applied a multiple emulsion with a combination of both extracts, once daily over the 60-day treatment researchers found that all groups show a significant improvement on skin roughness (SEr), scaliness (SEsc), smoothness (SEsm), and wrinkling (SEw). In compared to other 2 groups, green tea and lotus combined in multiple emulsions brought a superior synergistic anti-aging effect..



Dr. Mahmood T, the lead author, after taking into account of other con founders, said, "diverse anti-oxidant constituents in both plants have a potential influence on skin surface parameters, thus indicating these plants as the future of new anti-agingproducts".



Taken together, green tea bioactive polyphenols may be considered as a functional food used as topical or oral injection to delay skin aging process through over expression antioxidant in improved in both chronological (intrinsic) and photo-aging (extrinsic) aging.


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Reverse Infertility And Get Pregnant Naturally
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Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Combined topical application of lotus and green tea improves facial skin surface parameters by Mahmood T1, Akhtar N.(PubMed)
(2) Protective effects of green tea extracts on photoaging and photommunosuppression by Li YH1, Wu Y, Wei HC, Xu YY, Jia LL, Chen J, Yang XS, Dong GH, Gao XH, Chen HD.(PubMed)
(3) Anti-skin-aging effect of epigallocatechin gallate by regulating epidermal growth factor receptor pathway on aging mouse model induced by d-Galactose by Chen J1, Li Y2, Zhu Q1, Li T1, Lu H1, Wei N2, Huang Y1, Shi R2, Ma X3, Wang X4, Sheng J5.(PubMed)
(4) Cytoprotective Polyphenols Against Chronological Skin Aging and Cutaneous Photodamage by
Davinelli S, et al. Curr Pharm Des. 2017(PMC)

All About Green Tea: Green Tea In in Ameliorated Hair Loss and Promoted Hair Re-Growth

Green tea may have a therapeutic and positive effect in reduced hair loss and stimulated hair growth, some scientists suggested.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.

Hair loss can be temporary or permanent but in most cases it is a result of the levels of by-product prolactin of testosterone of men increases, stimulating the production of the enzyme 5-alpha reductase that causes the conversion of testosterone to gihydro-testosterones DHT, leading to hair grow-back thinner or not grow-back at all, particularly in people with androgenic alopecia hair loss problem.

According to statistic, approximately 40% of men have noticeable hair loss by age 35, 65% by age 60, and 80% by age 80.


Green tea, bioactive polyphenolic compounds in attenuated hair loss were found to associate to several mechanisms, involved certain aspects.


The examine of green tea epigallocatechin-3-gallate (EGCG), a major constituent of polyphenol on human dermal papilla cells (DPCs) in the prevention or treatment of androgenetic alopecia showed that injection of the green tea extract express a strong effect in inhibition of 5alpha-reductase activity in conversion of testosterone to gihydro-testosterones DHT selectively in activated human dermal papilla cells (DPCs) in stimulated hair follicle growth.



Further analysis suggested that EGCG activity in enhanced growth of human dermal papilla cells (DPCs) was attributed to influence hair growth by dermal papilla cells proliferation through the activation of ERK pathways involved functions in regulation of cell cycle in division and Akt pathway in promoted cells survival and growth.




Additional observation also found that green tea extract also increased the ratio of Bcl-2/Bax which has been found to associate to lower dermal papilla cells apoptosis and stimulate hair follicle regrowth.




More interestingly, the evaluation of the effect of dihydrotestosterone (DHT) in induced androgenic alopecia by shortening the hair follicle growth phase, resulting in hair loss in animal models, application of green tea epigallocatechin gallate (EGCG) protected against dihydrotestosterone (DHT) in induction of mediated human dermal papilla cells (DPCs) death through cell cycle arrest, cell viability, the generation of reactive oxygen species (ROS), and senescence by inhibiting expression of alternated mRNA in human dermal papilla cells (DPCs) induced by dihydrotestosterone (DHT) activity, thus increasing the regrowth of hair follicle, subsequently, in stimulated hair to grow-back.



Dr. Shin S, the lead author of the study said, "EGCG ameliorates the negative effects of DHT by altering the miRNA expression profile in human DPCs".


Houttuynia cordata Thunb (HC), a traditional herbal medicine widely used in Asia for the treatment of patients with alopecia containing green tea (GT) as a major ingredient, in 25 days experiment of six-week-old male C57BL/6 mice randomly divided into four groups (negative control, finasteride (1 mg/kg),a positive control, and two group fed with 200 and 400 mg/kg concentrations expressed a strong effect of area of hair regrowth 70.2 % and 83.5 % respectively, in compared to of 55.1 % negative control group. And increased diameter of hair follicles was 11.9 μm, 17.4 μm and 22.8 (±5.2) μm also found in negative control, herbal complex 200 and 400 mg/kg group, respectively.

Further more, the application of herbal formula at the doses indicated also increased expression of insulin-like growth factor (IGF)-1 which has a direct implication on clinical improvement of hair growth and decreased expression of TGF-β1 alternated mRNA transcription activated by androgen in human dermal papilla cells (DPCs) to induce gradually hair loss.


Finally, on hair loss among rodents, 60 female Balb/black mice with hair loss on the head, neck and dorsal areas were assigned randomly assigned to group A fed with 50% fraction of polyphenol extract from dehydrated green tea in their drinking water for six months and Group B received regular drinking water, researchers after taking into account of other con founders, found that mice fed with green tea extract demonstrate a significant hair regrowth of 33% during six months of treatment in compared to no hair growth control.

Taken together, green tea with abundant bioactive polyphenols such as epigallocatechin-3-gallate (EGCG) may have a significantly clinical effect in promoted hair growth and ameliorated hair loss.
through many direct and indirect perspectives. Intake of green tea extract should be taken with special care as overdoses were found to induce acute liver toxicity in some reports.


Pregnancy Miracle
Reverse Infertility And Get Pregnant Naturally
Using Holistic Ancient Chinese Medicine


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Human hair growth enhancement in vitro by green tea epigallocatechin-3-gallate (EGCG) by Kwon OS1, Han JH, Yoo HG, Chung JH, Cho KH, Eun HC, Kim KH.(PubMed)
(2) Epigallocatechin Gallate-Mediated Alteration of the MicroRNA Expression Profile in 5α-Dihydrotestosterone-Treated Human Dermal Papilla Cells by Shin S1, Kim K1, Lee MJ1, Lee J1, Choi S1, Kim KS1, Ko JM1, Han H1, Kim SY1, Youn HJ2, Ahn KJ2, An IS3, An S1, Cha HJ1(PubMed)
(3) The effects of tea polyphenolic compounds on hair loss among rodents by Esfandiari A1, Kelley P.(PubMed)
(4) An Asian traditional herbal complex containing Houttuynia cordata Thunb, Perilla frutescens Var. acuta and green tea stimulates hair growth in mice by Chung MS1, Bae WJ2,3, Choi SW3, Lee KW3, Jeong HC3, Bashraheel F3, Jeon SH3, Jung JW1, Yoon BI1, Kwon EB2,4, Oh HA4, Hwang SY4, Kim SW5,6.(PubMed)

All About Green Tea: Green Tea In Reduced Weight Gain and Promoted Weight Loss

Green tea polyphenols may have a therapeutic effect in reduced weight gain through decreased hormone expression with function direct influence of excess energy deposit, some scientists opinionated.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.

Weight gain is an increase in body weight, involved an increase in muscle mass, fat deposits, excess fluids.


In the compared green tea, polyphenols [epigallocatechin gallate (EGCG), epigallocatechin (EGC)] in decoction of green tea leaves versus usual green tea extracts to evaluate the effect in weigh gain in obese animal models fed with high fat diet, researchers after taking into account of other con-founders suggested that green tea decoction acute administration of GTD with 2/3 EGCG+1/3 EGC inhibited SGLT-1 activity involved distinct and complementing glucose homeostasis through absorbing glucose from the diet in the small intestine and by reabsorbing the filtered glucose in the tubular system of the kidney, thus reducing access energy being converted to glycogen or fat and deposit in liver, muscles and fat cells.



Additionally, green tea decoction not only improved glucose tolerance but also demonstrated a significant increase GLUT2 protein in facilitated glucose movement across cell membranes in the regulation of glucose absorption in distribution of dietary sugar to tissues to induce calorie restriction.



Chronic administration of green tea decoction GTD for 6 weeks, in the same experiment models also displayed a huge reduction of body weight gain, circulating triglycerides and cholesterol and improved glucose tolerance, through significantly reduced SGLT-1 as seen in acute application and and increased GLUT2 mRNA levels in the jejunum mucosa with function in increase the surface area of tissue available to absorb nutrients from ingested foodstuffs for decreased fat accumulation and glucose in liver.


Dr. Snoussi C, the lead auhtor said, "GTD-treated rats for 6 weeks display significantly reduced SGLT-1 and increased GLUT2 mRNA levels in the jejunum mucosa". This result showed that green tea decoction with polyphenols such as epigallocatechin gallate (EGCG), epigallocatechin (EGC) may have a certain effect in reduced weight gain through decreased fat deposit in the liver and promoted calorie restriction.

Further analysis of C57BL/6J mice fed a high-fat/high-sucrose diet (HF/HS, 32% energy from fat; 25% energy from sucrose) or the same diet supplemented with 0.25% GTP or BTP or a low-fat/high-sucrose (LF/HS, 10.6% energy from fat, 25% energy from sucrose) diet for 4 weeks showed that treatment with decaffeinated green tea (GT) polyphenols inhibited weight gain in mice fed an obesogenic diet as indicated above, through the rearrange the relative proportions of Blautia, Bryantella, Collinsella, Lactobacillus, Marvinbryantia, Turicibacter, Barnesiella, and Parabacteroides in correlated with weight loss by a decrease of cecum Firmicutes and increase in Bacteroidetes in the gastrointestinal tract.
In deed, GTP not only induced weight loss in association with alteration of the gut microbiota but also increased hepatic AMPK in reaction in sugar metabolism, and energy storage and release.


Interestingly, according to the START Clinic for the Mood and Anxiety Disorders, oral administration of green tea extract induced an unexpected decrease in total body fat mass, a decrease in body fat percentage and an increase in lean body mass in patients with weight gain induced by psychotropic medications.


Taken together, green tea, bioactive active polyphenols epigallocatechin gallate (EGCG), epigallocatechin (EGC) may be used as functional food in reduced weight gain induced by all sources and increased weigh loss through regulation of energy metabolism in fat accumulation.


Pregnancy Miracle
Reverse Infertility And Get Pregnant Naturally
Using Holistic Ancient Chinese Medicine


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Decaffeinated green and black tea polyphenols decrease weight gain and alter microbiome populations and function in diet-induced obese mice by Henning SM1, Yang J2, Hsu M2, Lee RP2, Grojean EM2, Ly A2, Tseng CH3, Heber D2, Li Z2.(PubMed)
(2) Green tea decoction improves glucose tolerance and reduces weight gain of rats fed normal and high-fat diet by Snoussi C1, Ducroc R2, Hamdaoui MH3, Dhaouadi K4, Abaidi H3, Cluzeaud F2, Nazaret C2, Le Gall M2, Bado A5.(PubMed)
(3) Weight gain and psychiatric treatment: Is there a role for green tea and conjugated linoleic acid? by Katzman MA1, Jacobs L, Marcus M, Vermani M, Logan AC.(PubMed)

All About Green Tea: Green Tea In Reduced Risk and Progression and Treatment of Kidney Cancer

Green tea may have a substantial and sustainable effect in reduced risk and treatment of renal cancer, some scientists suggested.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.

Kidney cancer is medical condition characterized by irregular cell growth in the issues of kidney. At the later stage, the cancerous cell may travel a distance away to invade other healthy tissues and organs.

According to statistic, kidney cancer is very uncommon in people younger than age 45 and among the 10 most common cancers in both gender.

Investigation of green tea effect in risk of renal cancer was found to associate to different implications involved numbers of mechanisms, particularly, in green tea bioactive components.

According to the evaluated 250 newly diagnosed, histo-logically confirmed Clear cell renal cell carcinoma (CCRCC) cases and 299 sex-, age-matched healthy controls provided complete information by face-to-face interview in Shanghai between 2007 and 2009, application of green tea at dose of ≥500 ml/d demonstrated a significantly inverse association to risk of CCRCC.



In deed, green tea consumption of lower than the said volume such as 8 oz (237 ml) or more cups/day was also associated to decrease renal cell cancer risk, in compared to non drinkers, according to the report of Brigham and Women's Hospital and Harvard Medical School.

Further analysis also found that interactions with the environmental exposures association to polymorphisms of the xenobiotic-metabolizing enzymes in induced CCRCC risk, also inhibited by green tea extract through increasing serum and liver antioxidant capacity and strengthening stability of microsomal and lysosomal membranes of healthy cells in compared to control.


In free radical aspect, the examine Wistar rats induced renal cancer pre-treated with N-ethyl-N-hydroxyethylnitrosamine (EHEN) by oral injection of drinking water for 2 weeks, also found that administration of green tea extract catechin ( 0.1% polyphenon-60) over 30 weeks of period of treatment exhibits a significant effect in decreased the incidence of renal cell tumors greater than 3 mm in diameter but not tumors that are less than 3 mm in diameter, through over expression of antioxidant in suppression of reactive oxygen species (ROS) induced by N-ethyl-N-hydroxyethylnitrosamine (EHEN) pre-treatment.




Importantly, in alternated gene expression in increased prevalence of cancer in human subjects,
application of green tea polyphenol, catechins have been reported to reverse change of DNA methylation in contributed to the tumor repressive gene of RGS2 (regulator of G-protein signaling 2) in modulated expression of cancers and increased the regulation of conversion of DNA to RNA (transcription) of these genes in ameliorated risk of renal and other cancer(s).


Further more, application of the combination of green tea extract bioactive catechins and epigallocatechin gallate also showed to modulate DNA methylation by attenuating the effect of DNA methyltransferase 1 (DNMT1) to ensure the fidelity of replication of inherited epigenetic patterns.

Aberrant DNA methylation patterns are associated with increased prevalence of renal and other tumor(s).

Taken together, Green Tea and its polyphenols bioactive compound catechins and epigallocatechin gallate may have a potential and therapeutic effect in reduced risk and treatment of renal cancer through antioxidants and anti gene alternative activities.


Pregnancy Miracle
Reverse Infertility And Get Pregnant Naturally
Using Holistic Ancient Chinese Medicine


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Risk factor for clear cell renal cell carcinoma in Chinese population: a case-control study by Wang G1, Hou J, Ma L, Xie J, Yin J, Xu D, Chang W, Tan X, Su T, Zhang H, Cao G.(PubMed)
(2) [Effects of green tea extract and its components on antioxidant status and activities of xenobiotic metabolizing enzymes of rats] by [Article in Russian](PubMed)
Kravchenko LV, Trusov NV, Aksenov IV, Avren'eva LI, Guseva GV, Lashneva NV, Tutel'ian VA.
(3) Intakes of coffee, tea, milk, soda and juice and renal cell cancer in a pooled analysis of 13 prospective studies byLee JE1, Hunter DJ, Spiegelman D, Adami HO, Bernstein L, van den Brandt PA, Buring JE, Cho E, English D, Folsom AR, Freudenheim JL, Gile GG, Giovannucci E, Horn-Ross PL, Leitzmann M, Marshall JR, Männistö S, McCullough ML, Miller AB, Parker AS, Pietinen P, Rod riguez C, Rohan TE, Schatzkin A, Schouten LJ, Willett WC, Wolk A, Zhang SM, Smith-Warner SA.(PubMed)
(4) Effect of polyphenon-60 on the development of renal cell tumors in rats treated with N-ethyl-N hydroxyethylnitrosamine byYoshioka N1, Hiasa Y, Cho M, Kitahori Y, Hirao K, Konishi N, Kuwashima S.(PubMed)
(5) Targeting DNA Methylation with Green Tea Catechins by Yiannakopoulou E.C.(Karger)

All About Green Tea: Green Tea In Reduced Risk, Progression and Treatment of and Neuro-Degenerative Diseases

Green tea is found to consist a substantial and respectful effect in reduced risk, progression and treatment of neuro-degenerative diseases, some scientists opinionated.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.

Neuro degenerative diseases are a class of conditions characterized by deteriorating neurons and accumulated plaque in blocking the neuro transmitters of the brain and spinal cords in performance of normal functions.

According to the statistic, approximately, 5 million Americans suffer from Alzheimer's disease, 1 million from Parkinson's and 400,000 from multiple sclerosis (MS) today, inducing overwhelming social, economic and health care burden on society.



The differentiation of green tea bioactive constituents in risk of neuro-degenerative diseases was found to associate to numbers of mechanism through many different aspects.


The investigation of green tea bioactive epigallocatechin-gallate (EGCG) activities in lipopolysaccharide- (LPS-) mediated systemic inflammation in induction of neurodegenerative diseases suggested that application of green tea chemical constituent demonstrated a significant effect in ameliorated LPS induced expression of proinflammatory cytokines of tumor necrosis factor alphaTNF-α, a cell signalling protein involved in systemic inflammation in the acute phase of infection, and interleukin 1 beta (IL1β), an cytokine with function in the regulation of immune and inflammatory responses to infections or sterile insults and interleukin 6 (IL-6) involved in inflammation and infection responses, particularly, in the inhibition of the expressions of inflammatory cytokines in the mononuclear blood cells (PBMCs), consisting lymphocytes (T cells, B cells, NK cells) with function to clear away of debris in the infection site.

The activation of inflammatory cytokines expression caused by lipopolysaccharide- (LPS) injection can trigger neurotoxicity, leading to neurons brains progressive degeneration, resulting in elevated risk of neuro degenerative diseases.

Application of green tea bioactive epigallocatechin-gallate (EGCG) was found not only inhibited LPS in precipitation of toxicity in resolved inflammation and mediated neuroprotection but also exerted anti toxicity through its antioxidant activity in decreased expression of reactive oxygen species in triggered brain cell apoptosis.


Interleukin 6 (IL-6) acts as both pro-inflammatory cytokines and an anti-inflammatory mytokines with function involved inflammation responses at sites of acute and chronic infection.

Further analysis of green tea Epigallo-catechin-3-gallate (EGCG) in the aspect of ROS in risk of neuro-degeneration in the dentate gyrus, part of the hippocampus and/or hippocampal formation of C57Bl/6 mice, suggested that the application promoted neural precursor cell, (a partially differentiated cell) proliferation, without changes at the level of immature and mature new neurons.



Interestingly, in adult hippocampal neurogenesis in male Balb/C mice, injection of green tea bioactive compounds in different doses also expressed a strong implication of increased cells survival without affecting cell proliferation but decreasing apoptotic cells.



The increased production of neuro precursor cell in stimulated neuro generation and increased cell survival from green tea was attributed to the green tea antioxidants acted as free radical scavengers to ameliorate chain reaction stimulated by reactive oxygen species (ROS).



Further more, green tea treatment was found to promote production of more elaborated dendritic (structures on the neuron that receive electrical messages) trees in young DCX-positive neurons with function in acquisition of spatial learning, as well as reversal learning, but not the retrieval of stored long-term memories.




Implication of green tea bio compounds EGCG also significantly increased net growth and development of nervous tissue in the adult hippocampus and hippocampal levels of phospho-Akt.in regulated multiple cellular processes, including glucose metabolism, apoptosis, cell proliferation, transcription and cell migration by re-establishing the function of PI3K in intracellular signaling pathway.

Dr. Neha Atulkumar Singh, the lead author in the article of "Potential neuroprotective properties of epigallocatechin-3-gallate (EGCG)",said, "there is a need to identify a class of drug capable of reversing neural damage and preventing further neural death" and "assesses the reliability of the neuroprotective benefits of epigallocatechin-gallate (EGCG) by shedding light on their biological, pharmacological, antioxidant and metal chelation properties, with emphasis on their ability to invoke a range of cellular mechanisms in the brain".


Taken together, green bioactive compound, EGCG may represent a potent and useful neuroprotective agent for inflammation-mediated neurological disorders and be considered as useful principle in modulated brain plasticity.



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Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(2) Potential neuroprotective properties of epigallocatechin-3-gallate (EGCG).
Singh NA1, Mandal AK2, Khan ZA3.(PubMed)
(*) Neuroprotective Activity of (-)-Epigallocatechin Gallate against Lipopolysaccharide-Mediated Cytotoxicity by Liu JB1, Zhou L1, Wang YZ2, Wang X2, Zhou Y2, Ho WZ3, Li JL2.(PubMed)
(*) Green tea compound epigallo-catechin-3-gallate (EGCG) increases neuronal survival in adult hippocampal neurogenesis in vivo and in vitro by Ortiz-López L1, Márquez-Valadez B2, Gómez-Sánchez A1, Silva-Lucero MD3, Torres-Pérez M1, Téllez-Ballesteros RI1, Ichwan M4, Meraz-Ríos MA5, Kempermann G6, Ramírez-Rodríguez GB7.(PubMed)