All About Green Tea: Green Tea In Ameliorated Risk, Progression and Treatment of Liver Fibrosis

Green tea may have a therapeutic and positive effect in reduced risk and treatment of Liver Fibrosis, some scientists suggested.

Green tea containingmore amount of antioxidants than any drink or food with the same volume, is the leaves of Camellia sinensis, undergone minimal oxidation during processing, originated from China.

Liver fibrosis is a liver disease with excessive accumulation of scar tissue as a result of inflammation and liver cell death

According to Fibro Test, approximately, the prevalence of advanced fibrosis was 2.8% in a general population aged 40 years or older.

According to the application of a novel bio-nano particle named 'Chitosan nano-encapsulated green tea extract' at the ultrastructural level on 25 adult rats induced liver toxicity by injection of carbon-tetrachloride and ethanol doses for 3 weeks, rats treated with novel substance expressed a significant reduction of nearly 25% of the sub-cellular area infected with hepatic fibrosis.

The efficacy of Chitosan nano-encapsulated green tea extract in decreased liver fibroids was attributed to the antioxidant activity in inhibited the expression of the injected chemicals in induction over production of reactive oxygen species (ROS) in chain reaction to elevated oxidative stress in initiation of liver cell apoptosis.

Observed by scanning electron microscopy, oral administration of novel bio-nano particle also exerted a strong free radical scavengers effect in protected against changes of cell surface structure and surrounding area between the hepatocytes, thus ameliorated risk of collagen deposit to cause liver fibroids.

Moreover, in carbon tetrachloride CCL4 induced fibrotic liver tissues in rat models, treatment of Green Tea Extract (GTE) encapsulated into Chitosan Nanoparties (CS-NPs) revealed that collagen fibers of 250 to 300 nm widths found in the fibrotic liver samples of control group with no treatment were cleared in green tea treatment group.

The effectiveness of GTE is reduced expression of collagen fibers in the liver a was found to correlate to the antioxidant expression in reduced CCL4 in induction of over production of free radicals in precipitated liver tissue damage.

Interestingly, in the evaluation of the protective effect of green tea extract (GT) on hepatic fibrosis in vitro and in vivo in dimethylnitrosamine (DMN)-induced rats, researchers at the Korea University, indicated that application of GT inhibited activated HSC-T6, a rat hepatic stellate cell line which is considered as the major cell type involved in liver fibrosis.

The application also attenuated the collagen deposition which are elevated and acted as a biomaker for progression of liver fibrosis, particularly, in expression of collagen type 1 formation of scar tissue in response to liver damage, found in the early event in the development of hepatic fibrosis, confirmed both by liver histology and by quantitative measurement of hepatic hydroxyproline content.

Dr. Kim HK, the lead author said, "green tea administration can effectively improve liver fibrosis caused by DMN, and may be used as a therapeutic option and preventive measure against hepatic fibrosis".

Taken together, green tea with abundant bioactive polyphenols may have a therapeutic and pharmaceutical effect in reduced risk, progression and treatment of liver fibroid caused by forming of scars as a result of liver damage through antioxidant activity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Effect of Green Tea Extract Encapsulated Into Chitosan Nanoparticles on Hepatic FibrosisCollagen Fibers Assessed by Atomic Force Microscopy in Rat Hepatic Fibrosis Model by Safer AM, Hanafy NA, Bharali DJ, Cui H, Mousa SA.(PubMed)
(2) Quantification of the Healing Effect in Hepatic Fibrosis Induced by Chitosan Nano-Encapsulated Green Tea in Rat Model by Safer AM, Sen A, Hanafy NA, Mousa SA.(PubMed)
(3) Antifibrotic effects of green tea on in vitro and in vivo models of liver fibrosis by Kim HK1, Yang TH, Cho HY.(PubMed)

All About Green Tea: Green Tea in Modulated Gastrointestinal Phases of Digestion

Green tea may have a therapeutic and positive effect in enhanced gastrointestinal function in food absorption, some scientists suggested.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.

According to the Agriculture and Agri-Food Canada, native catechins found in green tea were not absorbed by digestive system after intake. The polyphenol were accumulate in the intestinal lumen inside space of a tubular structure where they exhibited a significant activity in ameliorated cellular glucose and cholesterol uptake, thus reducing risk in over expression of fasting glucose and lipid accumulation entering the blood stream in induction of syndromes of abnormal high blood sugar and cholesterol.

The pervaded catechins found approximately, 2-15% in the intestinal levels significantly binded to 37% to plasma HDLs through inhibiting the key enzymes involved in lipid biosynthesis and reduced intestinal lipid absorption, thus improving blood lipid profile.action of cholesterol metabolism.

Further analysis of the unstable condition of polyphenols in intestinal environment, also found that transition from the gastric phase to the intestinal phase of green tea extract show a 50% decrease in the antioxidant activity due to the degradation of polyphenols but the deceased extract still exert a strong effect in gastrointestinal environment.

However, intake of whole food milk and cheese in the definition of dairy matrices displayed a significant improvement of polyphenol stability in the intestinal phase and increase of the antioxidant activity by 29% (cheese) to 42% (milk) in compared to non green tea injection control.

Additionally, administration of green tea also demonstrated a strong activity in decreased expression of stomach secretes pepsinogen, in breaking down milk and cheese protein and fat intake in degraded into their component polypeptide or amino acid and glycerol and fatty acids, respectively in the gastric phase but had no effect in the intestinal phase, thus reducing glucose and fat being absorbed and presented in the blood stream.

The finding evidences showed that green tea polyphenols intake together with dairy products improved antioxidant activity and enhanced the integrity of polyphenols during digestion.

Interestingly, in the evaluated rats fed with selenium-containing green tea (Se-GTE, 1.44 mg selenium/kg dry leaves) and China green tea(CH-GTE, 0.13 mg selenium/kg leaves) and China green tea(CH-GTE) effect in the intestinal micro bacterial activity researchers indicated that oral administration of rat group fed with Se-GTE extract for 6 days exerted a significant increase in caecal counts of lactobacilli and bifidobacteria while significantly reducing the caecal counts of bacteroides and clostridial bacteria in compared to CH-GTE rat group in slight but not significant increase in the numbers of caecal lactobacilli and bifidobacteria but decreased significantly the numbers of bacteroides (p < 0.05) and clostridia.

Moreover, rats fed with CH-GTE and Se-GTE showed a 17.2% and 21.3% reduction in the activity of the bacterial enzyme β-glucuronidase, which has been found in contribution of biliary sludge and stone formation and increased risk for colorectal cancer, respectively.

More promisingly, teatment of both CH-GTE and Se-GTE also resulted in 19% and 25.5% increments in the activity of β-glucosidase in reduced beta-D-glucosides and oligosaccharides in released glucose, respectively

Taken together, green tea with abundantly major bioactive polyphenols may be considered a function food in improved gastrointestinal function but reduced absorption of glucose and lipid in induction of abnormal high fasting blood sugar and cholesterol levels through binding to fat and protein in the gastric phase of digestion.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Interaction of green tea polyphenols with dairy matrices in a simulated gastrointestinal environment by Lamothe S1, Azimy N, Bazinet L, Couillard C, Britten M.(PubMed)
(2) Simulated gastrointestinal digestion, intestinal permeation and plasma protein interaction of white, green, and black tea polyphenols by Tenore GC1, Campiglia P2, Giannetti D3, Novellino E3.(PubMed)
(3) The ability of green tea to positively modulate key markers of gastrointestinalfunction in rats by Molan AL1, Liu Z, Tiwari R.(PubMed)

All About Green Tea: A Compilation of HOW Green Tea and Its Bioactive Epigallocatechin gallate EGCG in Reduced Risk and Treatment of Cardiovascular Diseases

Green tea containing bioactive polyphenols may have a strong implication in reduced risk and treatment of cardiovascular disease, some scientists postulated.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.

Cardiovascular disease are chronic medical condition characterized of narrowed or blocked blood vessels that can lead to a heart attack including chest pain (angina) or stroke.

According to statistic, heart disease is the second leading cause of death, claiming more than 48,000 lives every year.in Canada.

In the differentiation of green tea bioactive polyphenols epigallocatechin gallate or EGCG in risk of cardiovascular disease researchers at the joint study lead by the Colorado State University found that application of EGCG activated the expression of the nuclear erythroid-2 like factor-2 (Nrf2) transcription factor in stimulated transcription of antioxidative genes in protection of cell against oxidative stress in induction of CVD.

In compared to statins, the conventional medicine may be effective in reduced heart attacks and strokes in people at moderate and high risk but it can also cause cancers and multi-drug resistance cancer, EGCG ameliorated risk of CVD without giving rise to adverse effects.


Further analysis of EGCG efficacy in risk of cardiovascular disease and metabolic syndrome by searching literature published online of major scientific databases, from 1995 to 2017, scientists found that EGCG exhibits a wide range of therapeutic properties including associated with the inhibition of LDL cholesterol in reduced risk of plague accumulated in the arterial wall in elevated risk of atherosclerosis, attenuated angiotensin II (AngII) through inhibiting transcription factor NF-κB in induced abnormal enlargement, or thickening of the heart muscle, and reduced risk of highly oxidative enzyme myeloperoxidase(MPO) activity in promoted myocardial infarction, as level of myeloperoxidase(MPO) is considered as a biomaker used in assessment of risk of heart attack.

Additionally, EGCG also exerted significant and profound effects in ameliorated risk of diabetes through lowering plasma glucoses and gycated haemoglobin level, inhibited pro inflammatory factors in elevated inflammation in the early phase of acute infection and chronic infection as well as blocking expression of ROS in stimulated free radical chain reaction through its antioxidant activity.

Dr. Eng QY, after taking into account of other con founders, siad, "EGCG shows different biological activities and in this review, a compilation of how this bioactive molecule plays its role in treating cardiovascular and metabolic diseases".

Moreover, in a total of 9 studies including 259,267 individuals satisfied the criteria and guideline included in the meta-analysis.by examining published literature in evaluated the association between green tea consumption, CVD, and ischemic related diseases. up to October 2014, researchers indicated that for non green tea drinker, risk of CVD was 1.19, intracerebral hemorrhage was 1.24 and cerebral infarction was 1.15 in compared to people who drank <1 cup green tea per day.

Not surprisingly, people who drank 1-3 cups of green tea per day had a reduced risk of myocardial infarction 0.81, and stroke 0.64 in compared compared to those who drank <1 cup/day and who drank ≥4 cups/day had a reduced risk of myocardial infarction of 0.68 in compared to those who drank <1 cup/day.

And for people who consumed ≥10 cups/day of green tea were also shown to have lower LDL in compared to group who drank <3 cups/day.

Dr. Pang J, the lead author at the final stage of the experiment said, "(The) meta-analysis provides evidence that consumption of green tea is associated with favorable outcomes with respect to risk of cardiovascular and ischemic related diseases".
The results finding of all studies confirmed that consumption of green tea is associated with favorable outcomes with respect to risk of cardiovascular disease as well as expression of various serum markers in compilation of how green tea initiated protective activity against CVD.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(*) Molecular understanding of Epigallocatechin gallate (EGCG) in cardiovascular and metabolic diseases by Eng QY1, Thanikachalam PV1, Ramamurthy S2.(PubMed)
(*) The Role of the Nrf2/ARE Antioxidant System in Preventing Cardiovascular Diseases.
Smith RE1, Tran K2, Smith CC3, McDonald M4, Shejwalkar P5, Hara K6.(PubMed)
(1) Green tea consumption and risk of cardiovascular and ischemic related diseases: A meta-analysis by Pang J1, Zhang Z2, Zheng TZ3, Bassig BA4, Mao C5, Liu X5, Zhu Y4, Shi K6, Ge J7, Yang YJ8, Dejia-Huang5, Bai M9, Peng Y9.(PubMed)

All About Green Tea: Green Tea and its Bioactive Polyphenols Epigallocatechin-3-gallate in Attenuated Risk and Treatment of Autoimmune Hepatitis

Green tea may have a therapeutic and positive effect in reduced risk and treatment of autoimmune hepatitis, some scientists suggested.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.

Autoimmune hepatitis is a medical condition characterized by immune system attacking the liver cells in induction of liver cirrhosis as a result of long term liver cellular inflammation and necrosis.


The study of concanavalin A (ConA) (25 mg/kg) induced autoimmune hepatitis in mice, pretreatment of green tea exerted a strong inhibition of inflammatory cytokines through increased Bcl-2 expression with function of blocking the apoptotic death of some cells and deceased activity of protein Bax in activated p53 a tumor suppressor to induce cell death and caspase-3, and Caspase-9 proteins in signaling molecules in responsible for executing cell death in compared to ConA-treated group within 8 hours of applications, according to observation of TUNEL assay by detecting apoptotic cells that undergo extensive DNA degradation.


In other words, green tea EGCG administration reduced expression of ConA in induction of decreased numbers of infectious cells being attacked by the immune system, thus ameliorated risk of liver cell damage.


Further differentiation indicated that application of green tea bioactive polyphenols Epigallocatechin-3-gallate (10 or 30 mg/kg) orally twice daily for 10 days before ConA injection demonstrates a significant activity in reduced activation of BNIP3, a member of the apoptotic Bcl-2 protein family in mediated infectious cell apoptosis through autophagy in induced destruction of damaged or redundant cellular components in compared to lectin ConA.
The result of green tea EGCG efficacy in induction of BNIP3 to decrease expression of concanavalin A (ConA) in reduction of numbers infectious cell proliferation was attributed to the IL-6/JAK/STAT3 signaling pathway which plays an important role in the mechanisms in exhibited green tea EGCG antioxidant activity in blocking infectious cells migration and invasion in exhibited hepatoprotective effect.

In other words, said, Dr. Li S, the lead scientist "EGCG attenuated liver injury in ConA-induced hepatitis by down-regulating IL-6/JAKs/STAT3/BNIP3-mediated apoptosis and autophagy".

Further differentiation also found that green tea EGCG administration inhibited the immune over reaction and pathological damage by decreased expression of inflammatory cytokines induced by Tumor necrosis factor (TNF), tumor necrosis factor alpha, a cell signaling protein (cytokine) in activated systemic inflammation in the acute phase infection.


Additionally, green tea also modulated the inflammatory factors, interleukin 6 (IL-6), the pro inflammatory cytokines and anti inflammatory mytokins promptly and transiently produced in response to infections and tissue injuries and interferon-gamma (IFN-γ), a cytokine that plays an important role in inducing and modulating immune responses to the infectious tissue, as well as cytokine interleukin-1β (IL-1β), a key mediator of the inflammatory response in protected body against pathological invasion.

Taken together, green tea and its bioactive Epigallocatechin-3-gallate EGCG may be considered a functional food to reduced risk and used combination with standard therapy for treatment of autoimmune hepatitis.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Epigallocatechin-3-gallate attenuates apoptosis and autophagy in concanavalin A-induced hepatitis by inhibiting BNIP3. by Li S1, Xia Y1, Chen K1, Li J1, Liu T1, Wang F1, Lu J1, Zhou Y1, Guo C1.(PMC)

All About Green Tea: Green Tea and Bioactive Polyphenols Epigallocatechin gallate (EGCG) in Protection Against Memory Deficits

Green tea may have a therapeutic and positive effect in protected against memory deficits, some scientists suggested.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.ore

Memory deficit are,medical condition characterized lost of the ability in store and recall past information, such as knowledge, sensation, thoughts,......

Lost of memory function is not only associated with normal aging progression in adult population but considered as a feature of neurodegenerative diseases, including psychiatric and neurological disorders.

According to the Harvard neuro discovery center, today, approximately 5 million Americans suffer from Alzheimer's disease; 1 million from Parkinson's; 400,000 from multiple sclerosis (MS); 30,000 from amyotrophic lateral sclerosis (ALS or Lou Gehrig's disease), and 30,000 from Huntington's disease.

The evaluate green tea extract (GTex) and its major functional polyphenol (−)-epigallocatechin gallate (EGCG) effect on memory of cerebral ischemic rats showed that green tea EGCG and pentoxifylline (PTX), a methylxanthine derivative with anti-inflammatory function, application after 1 hour demonstrates a strong efficacy in improved ishemic-induced memory impairment, according to Morris water maze test.


Long term treatment of green tea EGCG also displayed a significant increase level of antioxidant such as malondialdehyde (MDA) levels, glutathione (GSH), and superoxide dismutase (SOD) activity in the cerebral cortex and hippocampus, through prevented cerebral infraction breakdown of MDA and GSH in the hippocampus, in protected against damage to cellular components caused by reactive oxygen species (ROS) including free radicals, peroxides, lipid peroxides....

Further analysis, green tea EGCG inhibited BV-2 microglia cells in induction of brain inflammatory effect in precipitated neurodegeneration and neuro toxicology to facilitate memory impairment, through ameliorated the expression of lipopolysaccharide- (LPS-) in exhibited free radical nitric oxide production which are associated to in initiated neurotoxicity.

Additionally, the applicatiopn also ameliorated the cyclooxygenase-2 (COX-2) expression associated with pro-inflammatory activities in mediated neurodegenerative processes of several acute and chronic diseases and expression of the inducible nitric oxide synthase (iNOS), one of the direct consequences of an inflammatory process in the BV-2 cells.


In short, the experiment of cerebral ischemia animal model indicated that green extract and its active polyphenol EGCG improved learning and memory deficits through exhibited antioxidant activity in reduction of oxidative stress and neuro-inflammation.

Moreover, green tea Epigallocatechin gallate (EGCG) with beneficial effects on the impairment in learning and memory also demonstrated in increased autophagic activation in getting rid of damage and dysfunctional cell accumulation to protect healthy neuron from stressful conditions, such as over expression of ROS presentation, according to the experiment of chronic unpredictable mild stress (CUMS)-induced cognitive impairment in rats and observed through the elevated LC3-II, a reliable method for monitoring autophagy and autophagy-related processes, including autophagic cell death.and p62 protein level, an useful marker for the induction of autophagy,


At the same time, the green tea EGCG also displayed a strong inhibition of increased neuronal loss and activated mammalian target of rapamycin (mTOR)/p70 ribosomal protein S6 kinase (p70S6k) signaling caused by implication of chronic unpredictable mild stress (CUMS) in the CA1 regions in the hippocampal circuit in initiation of the pathophysiology of memory deficits, thus reducing amyloid beta1-42 (Aβ1-42) deposit, and restored autophagic degradation activity.


Mammalian target of rapamycin (mTOR)/p70 ribosomal protein S6 kinase (p70S6k) signaling pathway is an essential cellular signaling pathway involved a number of important physiological functions, including cell growth, proliferation, metabolism, protein synthesis, and autophagy.

Taken together, green tea and its bioactive polyphenols Epigallocatechin gallate (EGCG) may be considered as adjunct therapy in reduced risk and enhanced standard medicine for treatment of memory deficits.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Green Tea Extract Ameliorates Learning and Memory Deficits in Ischemic Rats via Its Active Component Polyphenol Epigallocatechin-3-gallate by Modulation of Oxidative Stress and Neuroinflammation by Kuo-Jen Wu,1 Ming-Tsuen Hsieh,1 Chi-Rei Wu,1 W. Gibson Wood,2 and Yuh-Fung Chen(Hindawi)
(2) Epigallocatechin-3-Gallate Attenuates Impairment of Learning and Memory in Chronic Unpredictable Mild Stress-Treated Rats by Restoring Hippocampal Autophagic Flux by Hong-Feng Gu1,2., Ya-Xiong Nie3., Qiao-Zhen Tong2., Ya-Ling Tang1 , Yang Zeng3 , Kai-Quan Jing3 , XiLong Zheng2,4, Duan-Fang Liao4(PLOS 1)

All About Green Tea: Green tea and Its Polyphenols in Reduced Risk, Progression, Complications and Treatment of Liver Cirrhosis

Green tea may have a therapeutic and positive effect in reduced risk and treatment of liver cirrhosis, some scientists suggested.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.

Liver cirrhosis is a condition of abnormal function of liver due to damage liver tissue replaced by scar tissue.

According to statistic, risk of liver cirrhosis is 1.6% in adult population.


Green tea polyphenols in reduced risk and treatment of patients with liver cirrhosis was found to associate to numbers of implication, involving various mechanisms.

In male SD rats model induced liver cirrhosis through carbon tetrachloride(CCL4), randomly assigned to 3 groups, including normal group, green tea extract (GTE) group and cirrhosis group, with GTE group and the cirrhosis group were injected subcutanuously 2 times/wk over 9 weeks with 40% Carbon tetrachloride (CCl4), researcher found that green tea treatment groups displayed a significant reduction of concentration of hydroxyproline, an amino acid produced during the hydrolysis of collagen initiate scar accumulation in the liver damage tissue caused by CCl4) in compared to cirrhosis group.


Further analysis, also indicated that green tea exhibited antioxidant activities in decreased expression of malondialdehyde (MDA), a highly toxic reactive species in precipitated liver damage induced by application of carbon tetrachloride(CCL4).


Additionally, the green tea extract ameliorated the liver damage cell in formation of cirrhosis through attenuating the expression of transforming growth factor beta 1 or TGF-β1 in initiated cell growth, cell proliferation.

In differentiation of 11 patients with hepatitis C and detectable viremia of 4 Child-Pugh (CP) class A cirrhosis, 4 Child-Pugh class B cirrhosis, and 3 noncirrhotic, researchers at the Thomas Jefferson University indicated that injection of a single oral dose of green tea extract 400 mg containing 94% pure EGCG demonstrated a strong effect in reduced cirrhosis over expression in induction of liver tumor growth by inhibiting the virus hepatitis in facilitate the production of ROS species through chronic liver inflammation, according to the blood sample withdrawn from the patients without inducing liver toxicity.

Dr. Halegoua-De Marzio D, after taking into account of other con founders said, "A single 400-mg oral dose of EGCG was safe and well tolerated by all of the patients in the study" and disposition of EGCG was not significantly altered in these patients with cirrhosis".

Interestingly, in the concern of abnormal angiogenesis in patients with liver cirrhosis in induction of severe complications such as variceal haemorrhage and encephalopathy, Dr. Hsu SJ and colleges conducted a study to investigate the effect of green tea extract in Spraqtue-Dawley rats liver induced in by common BDL (bile duct ligation) in compared to control given distill water for 28 days and found that group treated with green tea extract expressed a strong implication in ameliorated the severity of portosystemic shunting, a rare malformation of the vessels supplying blood to the liver caused by excessive shunting of blood from the liver portal vein to the lower and middle body into the right atrium of the heart due to liver cirrhosis in induction portal hypertension and one of complication of variceal haemorrhage in patient with chronic liver cirrhosis and mesenteric angiogenesis in development of new blood vessels to supply oxygen and nutrients to initiate liver cancer.

Moreover, the effect of green tea GTP extract in reduced progression of liver cirrhosis was attributed to the suppression of hypoxia-inducible factor 1-alpha (HIF-1α) in expression of liver disease of diverse etiologies, including chronic liver diseases caused by viral infection, excessive alcohol consumption and activation of protein kinase B (Akt) in regulated infectious liver cell survival, cell-cycle progression,... and levels of VEGF in reflection of increased portal hypertension or decreased hepatic regenerative activity or the combination of both.

Dr.Hsu SJ, the lead author said after the conclusion, "GTP appears to be an appropriate agent in controlling portal hypertension-related complications via anti-angiogenesis.

Taken together, Green tea extract containing major polyphenols such as EGCG may be considered as a functional food in reduced risk, progression, complications and treatment of liver cirrhosis. Intake of green tea supplement should be taken with special care to prevent acute toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Green tea polyphenol decreases the severity of portosystemic collaterals and mesenteric angiogenesis in rats with liver cirrhosis by Hsu SJ, Wang SS, Hsin IF, Lee FY, Huang HC, Huo TI, Lee WS, Lin HC, Lee SD.(PubMed)
(2) [Green tea extracts protected against carbon tetrachloride-induced chronic liver damage and cirrhosis].[Article in Chinese] by Xiao J1, Lu R, Shen X, Wu M.(PubMed)
(3) Limited sampling estimates of epigallocatechin gallate exposures in cirrhotic and noncirrhotic patients with hepatitis C after single oral doses of green tea extract by Halegoua-De Marzio D1, Kraft WK, Daskalakis C, Ying X, Hawke RL, Navarro VJ.(PubMed)

All About Green Tea: Green Tea and Lower Dose of Its Bioactive Polyphenols (-)-Epigallocatechin-3-gallate (EGCG) in Reduced Cardiac Fibrosis in Induction of Heart Failure

Green tea may have a therapeutic and positive effect in reduced risk and treatment of cardiac fibroids some scientists suggested.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.

Cardiac fibrosis is a uncommon condition of abnormal thickening of the heart valves caused by inappropriate proliferation of cardiac fibroblasts but commonly, it is the excess deposition of molecules outside a cell or cells with structural and biochemical support to the surrounding cells in the cardiac muscle, leading to cardiac dysfunction and eventually heart failure.

The study of rat cardiac fibroblasts caused by injected by angiotensinII (AngII) also revealed that green tea inhibited the abnormal increase in level of connective tissue growth factor CTGF by decreased expression of the nuclear translocation of NF-κB p65 subunit and degradation of IκB-α in induced promotion of fibroblast proliferation and extracellular matrix (ECM) accumulation, thereby exacerbating cardiac hypertrophy and subsequent failure were attributed to bioactive polyphenol EGCG expression in significantly reduced collagen synthesis, fibronectin (FN) expression and cell proliferation.


In deed, due to the activity of CTGF as a matricellular protein modulating the fibrotic process in cardiac remodelling, some researchers suggested that the gowth factor may be considered as a biomarker for cardiac fibrosis for therapeutic intervention to mitigate fibrosis in the heart.

Interestingly, in the evaluated the effect of GABA tea, containing a high level of gamma-aminobutyric acid (GABA) in cardiac function with male Wistar rats injected with 55 mg/kg streptozotocin (STZ) to induce diabetes for 2 weeks and then orally given dosages of 4.55 and 45.5 mg/kg/day GABA tea extract for 6 weeks, researchers revealed that rats treated with injection of GABA tea not only induces fasting blood glucose levels returned to normal levels but also inhibits cardiac fibrosis in compared to untreated group.



Further experiments also showed that GABA tea in ameliorated cardiac deposit risk was attributed to inhibited the protein levels of tumor necrosis factor-alpha (TNF-alpha), Fas and activated caspase-8 and caspase-3 induced in STZ rats in mediated cardiomyocyte apoptosis which has been found in elevation in patient with cardiac dysfunction such as cardiac fibrosis and an indication of chronic hemodynamic overloading and early cardiac decompensation.

Dr. Cherng SH, the lead authors suggested," (GABA tea reduced)cardiac fibrosis (expression) in diabetic rats may be mediated by reducing blood glucose and further attenuating TNF-alpha expression and/or Fas/Fas ligand (FasL)-mediated apoptosis".

Unfortunately, injection of bioactive polyphenols (-)-Epigallocatechin-3-gallate (EGCG) in high dose was found to induce the oppositely effect by increasing cardiac fibroids.


According to the study of green tea bioactive polyphenols (-)-Epigallocatechin-3-gallate (EGCG) in risk of cardiac fibroids induction of myocardiotoxicity in animal model, at the the joint study lead by the Guangzhou Medical University, injection of EGCG 500 and 1000 mg/kg demonstrated a significant effect in initiated cardiac collagen synthesis involved in the formation of filtration systems, through cells differentiation in connective tissue growth factor (CTGF) mRNA expression and protein produced by fibroblasts.


Further more, the application of green tea extract also displayed an exhibited fibrosis-related protein expression in induction of cardiac fibroids deposit through stimulating function of fibronectin (FN), a ubiquitous extracellular matrix (ECM) glycoprotein circulated in the blood to initiated heart muscle repair.

After taking into account of other con confounders, Dr. Cai Y, the lead scientist said, "high oral doses of EGCG could induce cardiac fibrosis, and shed new light on the understanding of EGCG-mediated myocardiotoxicity".


The information findings suggested that green tea with bioactive poluphenols EGCG at lower dose may be used as function food in reduced risk of cardiovascular diseases caused by cardiac fibroids. In take of green tea supplement EGCG mus be taken with care as overdoses-toxicity has been reported in some cases.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) GABA tea prevents cardiac fibrosis by attenuating TNF-alpha and Fas/FasL-mediated apoptosis in streptozotocin-induced diabetic rats by Cherng SH1, Huang CY2, Kuo WW3, Lai SE4, Tseng CY5, Lin YM6, Tsai FJ7, Wang HF8.(PubMed)
(2) High doses of (-)-epigallocatechin-3-gallate from green tea induces cardiac fibrosis in mice by Cai Y1, He SQ2, Hong HQ3, Cai YP4, Zhao L5, Zhang M2.(PubMed)
(3) EGCG inhibits CTGF expression via blocking NF-κB activation in cardiac fibroblast by Cai Y1, Yu SS, Chen TT, Gao S, Geng B, Yu Y, Ye JT, Liu PQ.(PubMed)