Medical Advisor Journals

Monday, September 3, 2018

17 Incredible Medical Benefits of Turmeric: For Optimal Health, According to Cancer Perspective

Turmeric, principal curcuminoid of the popular Indian spice, a rhizomatous herbaceous perennial plant of the ginger family, Zingiberaceae, native to tropical South Asia, according to "Effects of different drying methods on the antioxidant properties of leaves and tea of ginger species" by E.W.C. Chan, Y.Y. Lim, S.K. Wong, K.K. Lim, S.P. Tan, F.S. Lianto and M.Y. Yong, posted in Science Direct. It has been used in traditional herbal medicine as an anti-inflammatory agent and to treat gastrointestinal symptoms associated with irritable bowel syndrome and other digestive disorders. Curcumin is a phytochemical found abundant in the plant. In acidic solutions (pH <7.4) it turns yellow, whereas in basic (pH > 8.6) solutions it turns bright red.

The Health Benefits according to Cancer Perspective
1. Bone cancer (Osteosarcoma(35%))
Curcumin the main ingredient of turmeric has shown to induce cell apoptosis in human osteosarcoma. Dr. Li Y, and scientists at the Qilu Hospital, Shandong University indicated that curcumin caused marked inhibition of osteosarcoma cell growth and G2/M phase cell cycle arrest. This was associated with concomitant attenuation of Notch-1 and downregulation of its downstream genes, such as matrix metalloproteinases, resulting in the inhibition of osteosarcoma cell invasion through Matrigel. We also found that specific downregulation of Notch-1 via small-interfering RNA prior to curcumin treatment resulted in enhanced inhibition of cell growth and invasion(1).

2. Bone cancer (Chondrosarcoma(25%))
Turmeric, principal curcuminoid of the popular Indian spice, a rhizomatousherbaceous perennial plant of the ginger family, Zingiberaceae, native to tropical South Asia, Curcumin the main ingredient of turmeric has shown to induce cell apoptosis in human chondrosarcoma. Dr. Lee HP, and scientists at the China Medical University Hospital, found that Curcumin induced upregulation of Fas, FasL, and DR5 expression in chondrosarcoma cells. Transfection of cells with Fas, FasL, or DR5 siRNA reduced curcumin-induced cell death. In addition, p53 involved in curcumin-mediated Fas, FasL, and DR5 expression and cell apoptosis in chondrosarcoma cells. Most importantly, animal studies revealed a dramatic 60% reduction in tumor volume after 21days of treatment(2).

3. Bone cancer (Ewing's sarcoma(16%))
Curcumin is a naturally occurring polyphenolic compound found in the turmeric. Under investigation as a chemotherapeutic and chemopreventive agent in adult cancer models at both pre-clinical and clinical levels. In this preliminary study, showed that curcumin is effective in causing cell cycle arrest, inducing apoptosis, and suppressing colony formation in the Ewing sarcoma cell line SK-NEP-1. Curcumin causes upregulation of cleaved caspase 3 and downregulation of phospho-Akt, producing apoptosis in Ewing sarcoma cells at an inhibitory concentration 50% (IC50) of approximately 4 μM. (3)

4. Cervical cancer
Epidemiological and preclinical evidence suggests that polyphenolic phytochemicals exemplified by epigallocatechin gallate from tea, curcumin from curry and soya isoflavones possess cancer chemopreventive properties. Dr. Thomasset SC and scientists at the University of Leicester, in the review of above showed that the available evidence for tea polyphenols tentatively supports their advancement into phase III clinical intervention trials aimed at the prevention of progression of prostate intraepithelial neoplasia, leukoplakia or premalignant cervical disease. In the case of curcumin and soya isoflavones more studies in premalignacies seem appropriate to optimise the nature and design of suitable phase III trials. The abundance of flavonoids and related polyphenols in the plant kingdom makes it possible that several hitherto uncharacterised agents with chemopreventive efficacy are still to be identified, which may constitute attractive alternatives to currently used chemopreventive drugs(4).

5. Hodgkin's lymphoma
Turmeric, a principal curcuminoid of the popular Indian spice, a rhizomatous herbaceous perennial plant of the ginger family, Zingiberaceae, native to tropical South Asia, according to "Effects of different drying methods on the antioxidant properties of leaves and tea of ginger species" by E.W.C. Chan, Y.Y. Lim, S.K. Wong, K.K. Lim, S.P. Tan, F.S. Lianto and M.Y. Yong, posted in Science Direct. It has been used in traditional herbal medicine as an anti-inflammatory agent and to treat gastrointestinal symptoms associated with irritable bowel syndrome and other digestive disorders. Curcumin is a phytochemical found abundant in the plant. In acidic solutions (pH <7.4) it turns yellow, whereas in basic (pH > 8.6) solutions it turns bright red. In the study to to find new therapies that specifically target the deregulated signaling cascades, such as NF-kappaB and STAT3, which cause Hodgkin and Reed-Sternberg (H-RS) cell proliferation and resistance of apoptosis, indicated that Curcumin is incorporated into H-RS cells and acts inhibiting both NF-kappaB and STAT3 activation, leading to a decreased expression of proteins involved in cell proliferation and apoptosis, e.g. Bcl-2, Bcl-xL, cFLIP, XIAP, c-IAP1, survivin, c-myc and cyclin D1. Interestingly, curcumin caused cell cycle arrest in G2-M and a significant reduction (80-97%) in H-RS cell viability. Furthermore, curcumin triggered cell death by apoptosis, as evidenced by the activation of caspase-3 and caspase-9, changes in nuclear morphology and phosphatidylserine translocation. The above findings provide a mechanistic rationale for the potential use of curcumin as a therapeutic agent for patients with HL(5).

6. Renal cell carcinoma (Kidney cancer/renal cells)
Curcumin (1,7-bis(4-hydroxy-3-methoxyphenyl)-1E,6E-heptadiene-3,5-dione or diferuloyl methane) is a polyphenol derived from the Curcuma longa plant, commonly known as turmeric.Dr. Kössler S and scientists at the Paracelsus Medical University, in the study of Curcumin affects cell survival and cell volume regulation in human renal and intestinal cells showed that Curcumin exposure induces apoptosis in human kidney cells, and at a concentration of 5.0-10 μM induces the appearance of a sub-population of cells with a dramatically increased volume. In these cells the regulation of the cell volume seems to be impaired, most likely as a consequence of the ICl(swell) blockade. Similarly, 50 μM curcumininduced apoptosis, caused cell cycle arrest in G1-phase and increased the volume of human colorectal adenocarcinoma HT-29 cells. The cell cycle arrest in G1 phase may be the mechanism underlying the volume increase observed in this cell line after exposure to curcumin(6)

7. Ovarian cancer
a. In the study to analyze the impact of sphingosine kinase-1 (SphK-1) inhibition on ceramides production, and evaluated SphK1 inhibitor II (SKI-II) as a potential curcumin chemo-sensitizer in ovarian cancer cells, found that inhibition of SphK1 by SKI-II or by RNA interference (RNAi) knockdown dramatically enhanced curcumin-induced apoptosis and growth inhibition in ovarian cancer cells. SKI-II facilitated curcumin-induced ceramides production, p38 activation and Akt inhibition. Inhibition of p38 by the pharmacological inhibitor (SB 203580), a dominant-negative expression vector, or by RNAi diminished curcumin and SKI-II co-administration-induced ovarian cancer cell apoptosis, and, to restore Akt activation by introducing a constitutively active Akt (CA-Akt), or to inhibit ceramides production by fumonisin B1 also inhibited curcumin plus SKI-II co-administration-induced in vitro anti-ovarian cancer effect(7).
b. Others found that curcumin exhibited time- and dose-dependent cytotoxicity against monolayer cultures of ovarian carcinoma cell lines with differing p53 status (wild-type p53: HEY, OVCA429; mutant p53: OCC1; null p53: SKOV3). In addition, p53 knockdown or p53 inhibition did not diminish curcumin killing of HEY cells, confirming p53-independent cytotoxicity. Curcumin also killed OVCA429, and SKOV3 cells grown as multicellular spheroids(7a).

8. Stomach Cancer/Gastric Cancer
Curcumin, a phytochemical compound found in Turmeric has exerted the inhibitory effect against Gastric Cancer. Dr. Sintara K and scientist at the Chulalongkorn University, indicated that curcumin treatments for 3 and 20 weeks reduced the cancer incidence resulting in a decrease of phospho-IκBα expression in benign tumor-bearing rats compared with MNU + s-NaCl. Curcumin treatment for 20 weeks also decreased 8-OHdG expression in benign tumor-bearing rats compared with MNU + s-NaCl. Curcumin can attenuate cancer via a reduction of phospho-IκBα and 8-OHdG expressions, which may play a promising role in gastriccarcinogenesis(8).

9. Skin cancer
In the study of curcumin loaded chitin nanogels (CCNGs) were developed using biocompatible and biodegradable chitin with an anticancer curcumindrug. Chitin, as well as curcumin, is insoluble in water,
indicated that The CCNGs showed a 4-fold increase in steady state transdermal flux of curcumin as compared to that of control curcuminsolution. The histopathology studies of the porcine skin samples treated with the prepared materials showed loosening of the horny layer of the epidermis, facilitating penetration with no observed signs of inflammation. These results suggest that the formulated CCNGs offer specific advantage for the treatment of melanoma, the most common and serious type of skin cancer, by effective transdermal penetration(9).

10. Prostate cancer
In the study to examine of a prospective study with 225 incident cases of prostate cancer in 12,395 California Seventh-Day Adventist men who in 1976 stated how often they drank soy milk.
suggests that men with high consumption of soy milk are at reduced risk of prostate cancer. Possible associations between soy bean products, isoflavones and prostate cancer risk should be further investigated(10).

11. Pancreatic cancer
the study of Impact of curcumin, raspberry extract, and neem leaf extract on rel protein-regulated cell death/radiosensitization in pancreatic cancercells showed that CUR, NLE, and RSE may serve as effective "deliverables" to potentiate RT in PC cure and further throw light that these phytochemicals-induced cell killing may involve selective regulation of RT-induced NF-κB(11).

12. Pharynx Cancer or pharyngeal cancer
In the study to investigate the mechanism underlying the curcumin-induced apoptosis of nasopharyngeal carcinoma (NPC) cell line NCE cells, indicated that Several evidences of apoptosis were obtained from curcumin-treated NCE cells by acridine orange and ethidium bromide stains, ultrastructure identification, DNA fragmentation assay and TUNEL staining. And the mean TUNEL-positive rates increased significantly at the 3 different time points (12 h, 24 h and 48 h; 25.6%, 40.3% and 54.5%, respectively). In the curcumin-treated-groups, delta psi m altered significantly and the positive rates increased in a time-dependent manner. At the 3 different time points, the mean positive rates were 26.8%, 42.3% and 68.2%, respectively. When caspase-3 activity was detected, 80.5% cells presented proteases activities after 12 h incubation with curcumin. Western Blot analysis showed that cytoplasmic cytochrome C increased significantly after incubation with curcumin. Flow cytometry and RT-PCR analysis showed that curcumin could up-regulate the Fas expression in time-depended manner , the positive rates of Fas protein increased from 33.6% to 89.9%(12).

13. Multiple myeloma (Myeloma)
In the study of Curcumin (diferuloylmethane) down-regulates the constitutive activation of nuclear factor-kappa B and IkappaBalpha kinase in human multiple myeloma cells, leading to suppression of proliferation and induction of apoptosis, scientists at the The University of Texas MD Anderson Cancer Center, showed that Curcumin suppressed the constitutive IkappaBalpha phosphorylation through the inhibition of IKK activity. Curcumin also down-regulated the expression of NF-kappaB-regulated gene products, including IkappaBalpha, Bcl-2, Bcl-x(L), cyclin D1, and interleukin-6. This led to the suppression of proliferation and arrest of cells at the G(1)/S phase of the cell cycle. Suppression of NF-kappaB complex by IKKgamma/NF-kappaB essential modulator-binding domain peptide also suppressed the proliferation of MM cells. Curcuminalso activated caspase-7 and caspase-9 and induced polyadenosine-5'-diphosphate-ribose polymerase (PARP) cleavage. Curcumin-induced down-regulation of NF-kappaB, a factor that has been implicated in chemoresistance, also induced chemosensitivity to vincristine and melphalan(13).

14. Oral cancer
Curcumin, a major active component and principal curcuminoid of the popular Indian spice of turmeric, ,has been shown to have inhibitory effects on cancers. Dr. Kim JY, and scientists in the study of Curcumin-induced autophagy contributes to the decreased survival of oral cancercells. indicated that curcumin induced reactive oxygen species (ROS) production and autophagic vacuoles formation by curcumin was almost completely blocked in the presence of N-acetylcystein (NAC), an antioxidant. Rescue experiments using an autophagy inhibitor suppressed curcumin-induced cell death in OSCC, confirming that autophagy acts as a pro-death signal. Furthermore, curcumin shows anticancer activity against OSCC via both autophagy and apoptosis (14).

15. Melanoma skin cancer
Curcumin is a phytochemical found abundant in the plant. In acidic solutions (pH <7.4) it turns yellow, whereas in basic (pH > 8.6) solutions it turns bright red. In the successfully incorporated curcumin into a bilayer of dodecanoic acid attached to magnetite nanoparticles in an effort to maximize solubility and delivery efficiency, found that fluorescent microscopy revealed that curcumin associated magnetite nanoparticles were internalized by the melanoma cells and remained in the cytoplasm. The curcumin/magnetic nanoparticles synthesized in this study possess magnetic and water solubility properties making this a novel curcuminformulation with therapeutic potential(15).

16. Non-Hodgkin's Lymphoma
In the study investigated a novel drug delivery nanovehicle enriched with the bioactive polyphenol, curcumin (curcumin nanodisks; curcumin-ND), showed that cells treated with curcumin-ND showed a dose-dependent increase in apoptosis. This was accompanied by enhanced generation of reactive oxygen species (ROS). The antioxidant, N-acetylcysteine, inhibited curcumin-ND induced apoptosis, suggesting that ROS generation plays a role in curcumin action on MCL cells. Curcumin-ND decreased cyclin D1, pAkt, pIκBα, and Bcl(2) protein. In addition, enhanced FoxO3a and p27 expression as well as caspase-9, -3, and poly(ADP-ribose) polymerase (PARP) cleavage were observed. Curcumin-ND treatment led to enhanced G(1) arrest in two cultured cell models of MCL(16).

17. Leukemia
Curcumin is a phytochemical found abundant in Turmeric. In acidic solutions (pH <7.4) it turns yellow, whereas in basic (pH > 8.6) solutions it turns bright red. In the study to investigate the anti-cancer effect and action of curcumin on THP-1 cells, showed that Curcumin induced cell apoptosis of THP-1 cells as shown by cell viability, cell cycle analysis and caspase activity. Curcumin significantly increased the phosphorylation of ERK, JNK and their downstream molecules (c-Jun and Jun B). Inhibitor of JNK and ERK reduced the pro-apoptotic effect of curcumin on THP-1 cells as evidenced by caspase activity and the activation of ERK/JNK/Jun cascades. On the contrary, the pro-apoptotic effect of curcumin was abolished in the differentiated THP-1 cells mediated by PMA(17).

Side effects
1. Overdose may cause gastrointestinal discomfort such as nausea and diarrhea and liver damage.
2. Topical use may be allergic to skin such irritation to certain peoples
3. Do not use the herb in new born, children or if you are pregnant and breast feeding without approval from the related field specialist.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sunday, September 2, 2018

The Herbal Remedies That Tonify and Detox Your Kidney for Optimal Health

Detoxification is a natural process in removal of toxic substances of human body, mainly carried out by the liver and kidney.
1. Dandelion leaf
Dandelion is a rich source of vitamins A, B complex, C, and D, as well as minerals such as iron, potassium, and zinc.

Dandelion leaf has been used in traditional Chinese medicine as a diuretic to stimulate the excretion of urine in removing toxin accumulated in the kidney.

2. Echinacea
Commonly called purple coneflower.

Echinacea contains a wide variety of chemicals that not only helps to strengthen the immune system but also stimulates the removal of toxins by kidney in reduced implications of inflammation and infection.

3. Corn silk
Corn silks are the silky fibers found under the leaves and on top of an ear of corn. The herbal medicine contains flavonoids, essential oil and minerals with function in treating acute and chronic inflammation of the urinary system caused by toxins accumulated in the kidney.

4. Apple
Apples containing high amounts of vitamins A, C, E and a variety of antioxidants not only strengthens our immune system but also cleanses our kidney from toxins through urinary extraction and preventing kidney inflammation.

5. Artichoke
Artichoke is a perennial thistle originating from southern Europe containing thiamin, riboflavin, niacin.

The herb major bioactive antioxidants were effective in strengthening our immune system and tonifying the kidney function by stimulating secretion of protein in the urine caused by long term toxins accumulation.

6. Golden rod
Golden rod is a yellow flowering plant in the family of Asteraceae.

The herb has been used in traditional medicines to improve kidney function, in treating kidney infections and expelling kidney stones.

Golden rod juice also helps to cleanse of kidney and bladder caused by toxins and inflammation.

Saturday, September 1, 2018

The Secrets of ANTI Aging Signs Vitamin That Enhances (Type 1 & 4) Collagen, Smooths Wrinkles, Inhibits Aging Spots, Fine Lines, and Improves Overall Intensity of Pigmentation and More

Skin aging is one of most visible process which occurs constantly in our skin organ.

According to the Clinical Centre of Nis, certain plant extracts may have the ability to scavenge free radicals, to protect the skin matrix through the inhibition of enzymatic degradation, or to promote collagen synthesis in the skin, affect skin elasticity and tightness(a).

Other suggested that free radicals induced domino effects in production of reactive oxygen species, can react with DNA, proteins, and fatty acids, causing oxidative damage and impairment of antioxidant system, leading injuries damage regulation pathways of skin, including wrinkles, roughness, appearance of fine lines, lack of elasticity, and de- or hyperpigmentation marks(b).

Vitamin C, also known as L-ascorbic acid, is a water-soluble vitamin, found in fresh fruits, berries and green vegetables.

The water soluble vitamin is best known for its free radical scavengers activity and regenerating oxidized vitamin E for immune support.

In skin aging, the vitamin may improve solar radiation protection and epidermal aging(1) through production of collagen due to its antioxidant activity(2)(3).

Epidemiological studies, linking vitamin C in prevention of skin damage and aging have produced some certain results(3a)(3b)(3c), but the large sample size and multi canters studies are necessary to validate it effectiveness.

L-ascorbic acid, was known for its effects on skin-whitening anti-oxidation causes of skin aging.

During the aging process, levels of vitamin C was found slowly deplete, according to Tokyo Metropolitan Institute of Gerontology in the measurement of plasma and urine of C57BL/6 male mice turnover during 3 to 30 months of aging(4).

Therefore, restoration of physiological levels of vitamin C inside the cells might improve the lysosomal degradation (protection of cell from the degradative enzymes, through protection of the cytosol) in the outflow pathway cells and prevent the pathogenesis of glaucomadegrade proteins(5).

Unfortunately, some researchers suggested that higher levels of circulating vitamin C may not provide protection against incident radiographic knee OA, and be associated with an increased risk of knee OA(6).

Panorama Research Institute and Regenerative Sciences Institute, insisted "careful attention to individual and family medical history and personal genomic data may prove essential to make wise dietary and supplement choices to be combined with exercise(7).

According to the Minghsin University of Science and Technology, in doses dependent manner, concentration of L-ascorbic acid, induced absorption of the collagen solution in exhibition of smoothing wrinkles and clear up the spots(8).

Ascorbic acid (AA) is essential in stimulation for collagen gene expression. In type 1 and type 4 collagen and SVCT2, the vitamin was found to enhance the expression of type 1 and type 4 collagens and SVCT2 mRNA in cultured human skin fibroblasts at 100 μM AA placed every 24h for 5 days to prevent depletion(9).

The Chiang Mai University study also supported the effects of ascorbic acid in anti-aging process through exhibition pro and active MMP-2 inhibitory(10).

Other study suggested the combined vitamins, including vitamin C in a single formulation had a slightly lower degradation rate and more stable formulations as compared to different preparations containing only one of the vitamins(11)(12).

Amazingly, in vivo, application of vitamin C showed a significant reduction of oxidative stress in the skin, an improvement of the epidermal-dermal microstructure and a reduction of fine lines and wrinkles in aged skin within a relatively short period of time of product application(13).

The Bruce and Associates study also insisted the effectiveness of vitamin C application over 12 week period as the vitamin enhanced the overall intensity of pigmentation, fine lines and wrinkles, tactile roughness, and laxity with 100% of satisfied overall appearance of tested subject skin(14).

Taken altogether, vitamin C was found to be effective in slowdown skin aging regardless to the cause, through its antioxidant status, down regulated the expression of Matrix metalloproteinase (MMPs) and enhanced production of collagens. Daily ingestion of high-dose vitamin Cmay be considered safe, but in rare incidence, overdoses in a prolonged period of time, may cause intra-renal oxalate crystal deposition, a fatal nephrotoxicity(15)(16).

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

References

(a) Skin ageing: natural weapons and strategies by Binic I1, Lazarevic V, Ljubenovic M, Mojsa J, Sokolovic D.(PubMed)
(b) Phytoconstituents as photoprotective novel cosmetic formulations by Saraf S1, Kaur CD.(PubMed)
(1) Hass avocado composition and potential health effects by Dreher ML1, Davenport AJ.(PubMed)
(2) The effects of a daily facial lotion containing vitamins B3 and E and provitamin B5 on the facial skin of Indian women: a randomized, double-blind trial by Jerajani HR1, Mizoguchi H, Li J, Whittenbarger DJ, Marmor MJ(PubMed)
(3) A bioactive complex to protect proteins from UV-induced oxidation in human epidermis, by Schweikert K1, Gafner F, Dell'Acqua G.(PubMed)
(4) Protective effects of a cream containing Dead Sea minerals against UVB-induced stress in human skin by Portugal-Cohen M1, Soroka Y, Ma'or Z, Oron M, Zioni T, Brégégère FM, Neuman R, Kohen R, Milner Y.(PubMed)
(5) Topical use of dexpanthenol in skin disorders by Ebner F1, Heller A, Rippke F, Tausch I.(PubMed)
(6) Dexpanthenol enhances skin barrier repair and reduces inflammation after sodium lauryl sulphate-induced irritation by Proksch E1, Nissen HP.(PubMed)

Friday, August 31, 2018

Wild Carrot, The Root Vegetable Which Gobbles Up Skin Cancer Cells, Online Published Medical Literature Showed

Carrots may have a profound and substantial effect in reduced risk, progression and treatment of skin cancer, some scientists suggested.

Skin cancer is a condition characterized by cell growth disorderly and uncontrollably in skin tissue. At the later stage, the cancerous cells may infect other healthy tissue and organ a distance away from the original site.

Carrot, a root vegetable with orange color is a sub spices of Daucus carota, belongings to the family Apiaceae, native to Asian and Europe.

In the investigation of essential oil isolated from wild carrot umbels effect in mice induced skin cancer through injection of 7,12-dimethyl benz(a)anthracene (DMBA), after 20 weeks of administered to animals via gavage (0.02 mL of 100% oil), intraperitoneal (0.3 mL of 2% oil), and topical (0.2 mL of 5, 50, and 100% oil) with half maximal inhibitory concentration IC50, researchers showed that topical administration of 100% mice group exerted in delay skin cancer appearance and inhibited tumor incidence of 89%.

With concentration of IC40, topical 50% and 5% treatment inhibited tumor incidence by 83% and 36%, respectively.

Topical ingestion of 100, 50, and 5% oil, also revealed a significant decreased of tumor volume by 99, 91, and 70%, respectively.

Intraperitoneally, treatment mice displayed a inhibited tumor by 43%, and decreased tumor volume by 85%, whereas gavage treatment showed minimal effects on both.
These results suggested that intraperitoneal and topical treatment of wild carrot essential oil decreased infiltration and proliferation with an increase of abnormal thickening of the outer layer of the skin.

Further analysis of the wild carrot essential oil anti cancer effect on human epidermal keratinocytes and the chemopreventive activity of the pentane diethyl ether fraction on DMBA/TPA induced skin carcinogenesis in mice, scientists in the joint study lead by the Lebanese American University suggested that application of all fractions isolated from the essential oil exhibited significant cytotoxicity, with HaCaT cells being 2.4-3 times less sensitive than HaCaT-ras A5 (benign tumorigenic), and HaCaT-ras II4 (malignant) cells observed by western blot.

In Gas chromatography–mass spectrometry, 2-himacharlen-6-ol. a derivative isolated from pentane/diethylether fraction (F2), demonstrated strong inhibition of HaCaT-ras A5 and HaCaT-ras II4 cells through cell cycle arrest in the accumulation of cells of the sub-G1 apoptotic phase and apoptosis in decreased the population of cells in the S and G2/M phases.

These results were attributed to the F2 fraction in enhanced of the expression of pro-apoptotic (Bax) in induction cellular apoptosis and attenuated expression of anti-apoptotic (Bcl2) proteins in promoted cancer proliferation.

Interestingly, all fractions also decreased the phosphorylation of AKT, (AKT is an essential component of the PI3K (phosphatidylinositol 3-kinase pathway) in monitor skin cancer cell growth and resistance to apoptosis and ERK(components of mitogen-Activated Protein Kinase (MAPK) signaling pathways) in mediated different anti proliferative events, such as apoptosis, autophagy and senescence.

Based on the information fonding, Dr. Shebaby WN, the lead author said, " F2 fraction has a remarkable antitumor activity against DMBA/TPA-induced skin carcinogenesis, an effect that may be mediated through inhibition of the MAPK/ERK and PI3K/AKT pathways".

The above differentiation were supported by the joint study lead by the University of Surrey in evaluation of Daucus carota oil extract (DCOE) activity in inhibtion of HaCaT-ras II-4 epidermal squamous cells.

According to the experiment, β-2-himachalen-6-ol isolated from the wild carrot essential oil at dose-dependent decreased in skin cell survival with an IC50 and IC90 of 8 and 30 μg/ml, respectively.

Observation of Flow cytometry analysis also revealed that treatment of by β-2-himachalen-6-ol is linearly associated to volume injection, as dose of 10 μg/ml HC significantly increased the number of cells undergoing late apoptosis (28%), while 25 μg/ml caused a larger cell shift towards late apoptosis (46.6%) and necrosis (39%).

Beside decreasing the phosphorylation of AKT, and ERK as shown in the mentioned above, β-2-himachalen-6-ol also inhibited the significant decrease in protein levels of p53 and Bcl-2 in acting as tumours suppressor, caused by 7,12-Dimethylbenz[a]anthracene (DMBA)/ 12-O-tetradecanoylphorbol-13-acetate (TPA) and increased p21 and Bax function in cell cycle arrest and activation of apoptosis.

Astonishingly, application of essential oil extract of wild carrot inhibited skin cancer proliferation and induced apoptosis withing harming the nearby healthy cells in tested mice.

Taken together, essential oil of carrot and its bioactive derivative may be considered as an adjunct therapy in reduced risk, progression and used combination with standard medicine for treatment of skin cancer.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Chemopreventive effects of wild carrot oil against 7,12-dimethyl benz(a)anthracene-induced squamous cell carcinoma in mice by Zeinab RA1, Mroueh M, Diab-Assaf M, Jurjus A, Wex B, Sakr A, Daher CF(PubMed)
(2) Wild carrot pentane-based fractions suppress proliferation of human HaCaT keratinocytes and protect against chemically-induced skin cancer by Shebaby WN1, Mroueh MA2, Boukamp P3,4, Taleb RI1, Bodman-Smith K5, El-Sibai M1, Daher CF(PubMed)
(3) β-2-himachalen-6-ol protects against skin cancer development in vitro and in vivo by Daaboul HE1, Daher CF2, Taleb RI2, Boulos J2, Bodman-Smith K1, Boukamp P3,4, Shebaby WN2, Dagher C5, El-Sibai M2, Mroueh MA(PubMed)

Thursday, August 30, 2018

The Theories of Skin Aging, You Probably Don't Know

Aging in a natural process is getting old.

Biologically, the process may also be characterized by ceased dividing (cellular senescence) of single cells within an organism.

Skin aging is one of most visible process which occurs constantly in our skin organ

Theories of aging
What cause aging? The question that has been asked throughout the human history, but it doesn't seem to get any answer but raises many more unanswered question. While many theories try to answer the question by related aging to tear and wear of the body, others deal with how the organs and systems in the body develop and deteriorate overtime, etc.

1. Somatic mutation theory
In this theory, aging is due to our inherited genes that come directly from our parents. Since the conception occurred, our body cells continue to divide and replication themselves. Since the division and replication are a life long precess at some point, for what ever reason, if cells division and replication can process incorrectly, leading to mutation of incorrect copy of DNA. Although the cause of this incorrect process are unknown, but researchers found that exposures to toxins, radiation or ultraviolet light, artificial ingredients, unhealthy life style, etc. can increase the risk of cells mutation and the cells copied incorrectly can mutate themselves, leading to accumulation of incorrect gene cells that trigger a chain reaction of an auto-catalytic nature in producing more and more fincorrect gene cell, until it finally is brought under controlled, this processes can lead to aging. As an organism, the immune system tries to destroy or scavenger these mutated genes but at some points, it is over whelming, leading chronic age related diseases.

2. Error catastrophe theory
The error catastrophe of aging, originally proposed by Leslie Orgel in 1963. Our body immune system helps to maintain the structural integrity of DNA not only for cell survival but also for the transfer of correct genetic information to the daughter cells. Error catastrophe indicated that alterations DNA and the incorrect placement of amino acids in protein synthesis could result in a progressive degradation aging as a result of these abnormal protein are no longer functioning as chemical passengers or signalers.

3. Protein glycosylation
Protein glycosylation is a result of chemical reaction of glucose with vary proteins, including enzyme, elastin and collagen in the blood. The cross linked protein glycosylation leads to cell to cell adhesion causing stiffness and rigidity of individual cells, reducing the cells function in taking nutrients and expelling waste.
If the cross link protein glycosylation occurs in the elastin and collagen, it will cause brittle skin, causing aging, but it happens in the organs it will be more serious and sometimes life threatening.

4. The neuroendocrine theory
First proposed by Professor Vladimir Dilman and Ward Dean MD, this theory postulates on wear and tear of the neuroendocrine system. In neuroendocrine system, the master pituitary gland secrets hormones to direct other glands in secreting their hormones and works conjunction with the hypothalamus glands form a command post in the nervous system in closely direct the function of most of the body functions.
but as we age, the hypothalamus loses its ability as a hormone regulator as its receptors of which uptake other gland hormones become less sensitive to them, including sex hormones, DHEA, serotonin, melatonin, etc.
As for cortisol, a hormone secreted by the adrenal glands due to stress, is produced with abundance as we age.

5. Immune system decline theory
As we age, our immune system is weakening that cause us become vulnerable to the dangerous pathogens, including microbial and viral invasion. Within the immune system, the thymus glands which play an important role in helping formation of the immune system scavenger that reduces the function of immune system further that allow irregular cell growth cause of aging spot, tumors, cancer, infection, inflammation and onset of chronic illness.

6. Genetic programming theory
Genetic programming theory propose that aging is programmed as the cells cycle in our body are also genetic program since their inception. the explanation is that all the cells are undergoing certain time in division over the a said amount of time before dying, leading to conclusion that people with the long live genetic program live longer than others who do not.
The theory also emphasizes the genetic diseases as a result of genetic programing diminished life span, regardless external and internal influence.
Further refinement of the programmed senescence theory was developed by Bernard Strehler, who proposed that as cells are program to perform specific functions within the organism that cause them to lose some of the ability to duplicate their genetic information, leading to aging.

7. Hayflick limit
The Hayflick limit (or Hayflick Phenomena) theory discovered by Leonard Hayflick and a biologist in 1966. In vitro study, the number of times a fibroblast diploid cells will divide before it stops. The discover is conferring a major hypothesis if the cell division can prolong in a infinite matter without conditions which cause damage of the cells, then organism can liver forever.
Exceptions:
Stem cells
Since stem cells can continue to regenerate new cells for the entire lifespan of the organism, without limit, thus constituting a notable exception to the Hayflick limit theory.
Cancer cells
Cancer cell in biological aspect, have found a way around the limit by becoming a group of immortalized cells produced from cell division that have no limit as to how many times this immortalized cell division might take place.

8. The telomerase theory
The tolomerrase theory is a continuation of support to the Hayflick limit (or Hayflick Phenomena) theory involved in telomeres and telomerase. Telomeres are the structure at the end of the chromosome. As each time the cell divides, its telomeres is shortened, at certain length, the cell stops division and goes into senescence.
The experiment shows, the cell senescence can be reversed by controlling the genes of telomerase autocatalytic nature, which in turn, promotes the forever cell division capacity

9. The free radical theory
A free radical is any atom or molecule that has a single unpaired electron in an outer shell and highly reactive to react with other cell, which in turn, causes oxidative damage to the enzymes, other protein, unsaturated fatty acid, phospho-lipids, DNA and RNA, etc., leading to aging of the organisms, as a result of widespread damage due to set of a chain reaction auto-catalytically after attacking the lipid bilayers of the cell walls.

10. Other theories
a. Rate of living and lifespan
Rate of living is defined that a bigger organism, the longer it lives with human is one of the exception due to its slower rate of metabolism and lower rate of free radical activity, leading to low levels of age lipid pigment, resulting in longer life span. Experiment show that there 100,000 free radicals hit everyday in rat, comparing 10, 000 in human.
b. Caloric restriction
Caloric restriction hypothesis suggested in a study of young rat showed that if a rat is put into restricted diet with given of necessary nutrients, it lives longer than those were allowed to eat freely. With the result also the same in the old rat, the theory also suggest eating less may cause less toxins in the body that affects the immune system and reduces the risk of hormone change, leading to free radicals cause of aging.
c. Age spots
Age spots are mainly composed of lipofuscin and lipopigment caused by reaction of free radical and peroxidation, leading to the formation of age spot, as a result of oxygen species interact with autophagocytic degradation occurring inside the lysosomes.
d. Protein oxidation
Protein oxidation cay affect protein function in normal and pathological processes as a result of postranslation protein being alter by reduce oxygen species (ROS) cause of damage to enzyme, leading to dysfunction of its role resulting in aging.
e. Fast track of aging
The theory suggest that there are many of diseases and syndromes of which can contribute to faster track to aging
* Hutchison-Gilford syndrome
It is an extremely rare genetic condition wherein symptoms resembling aspects of aging are manifested at an early age. Those born with progeria typically live to thirteen years, although many have been known to live into their late teens and early twenties and rare individuals may even reach their forties due to genes mutation.
*Werner syndrome
It is Adult progeria, an disorder causes the appearance of premature aging. The syndrome does not develop until they reach puberty is caused by autosomal recessive disorder due to alter gene on chromosome 8.
f. Altered genes
Alter genes are the work of Friedman and Johnson 1988 " .... the effect of elevated expression of SIR2 in yeast appears to be conserved in C. elegans (Tissenbaum & Guarente 2001) and Drosophila (Rogina & Helfand 2004), and mutations in genes encoding components of the target of rapamycin (TOR) pathway also extend the lifespan in all four organisms... "
"... It was originally suspected that extension of lifespan by reduced IIS might turn out to be a worm peculiarity. This was because mutations in genes in the IIS pathway can also cause the worms to enter a type of developmental arrest (dauer), normally seen only in response to low food or crowding (Riddle & Albert 1997). Dauer larvae are long lived, and the long life of IIS mutant adult worms could therefore have been a result of re-expression in the adult of the genes that make the dauer larva long lived...."
g. Free radical connection
Free radical is any atom or molecule that has a single unpaired electron in an outer shell and accumulation of free radical damage over time can cause aging. Theory is first proposed by Denham Harman in the 1950sand in the 1970s extended the idea to implicate mitochondrial production of reactive oxygen species into the 1970s. Study showed that nutant strains of the roundworm that are more susceptible to free radicals have shortened lifespans, and those with less susceptibility have longer lifespans
If free radical causes damage to the DNA repaired enzymes, it can increase the risk of unrepaired DNA damage, leading protein synthesis incorrectly. In fact, free radicals can inflict damage to all celsl in body such as endocrine glands, leading to decreasing of hormone secretion, resulting in aging and Kupffer cell in liver, causing endotoxins accumulated in the blood, leading to more free radicals attacks the immune system, etc.

10. Hormone depletion
The researchers found that if an decrease or absence of the pituitary gland hormones mice is given enough amount of pituitary hormones, it lives longer than a control group of normal mice as it stimulates the production of growth and other hormones such as prolactin, adrenocorticotropic hormone, thyroid-stimulating hormone, etc.

Wednesday, August 29, 2018

How to Detox Your Body with Supplements

American diet is high in saturated fat, trans fat, and other harmful substances such as sugar, caffeine, pesticides, additive substances, and less in fruits and vegetables.

These types of harmful substances are toxic.

Our body's detoxifying functions try to get rid of them everyday, when they fail it causes disruption of hormone production, damaging our body's detoxification organs and weakens our immune system.

Fortunately, some vitamins and supplements may have profound and therapeutic effects in increase the function of detox organs in getting rid of them.

1. Vitamins C and A
Vitamin C is an antioxidant and also has a mighty function in increased absorption of nutrient intake.

Without enough vitamin C, food entering our stomach is either wasted or little digested.

Be sure to add vitamin C your food intake together with vitamin A.
The vitamins also promote strong immune system, dissolve heavy metal accumulated in our body and prevent the loss of eyesight in elders.

Remember, overdose of vitamin C can causes diarrhea and vitamin A can induce acute liver toxicity.

2. Be Sure to Have a Balance of Magnesium and Calcium
Mineral deficiency causes our body to pick up other forms of toxic minerals for compensation, leading to weakening our tissue and bones.

Unbalanced or deficiency of magnesium and calcium decreases the function of our heart as well as increasing the risk of calcium sticking on the arterial wall and arthritis.

3. Vitamin E
Vitamin E promotes the production of sperm and testosterone in men.

In the form of tocopherone and d-alpha tocopherol, the vitamin reduces the accumulation of heavy metals in the brain, increases the physical activities and mental sharpness, and decreases the risk of muscular degeneration.

4. Zinc
Zinc is a critical mineral for prostate gland in men.

Deficiency of zinc not only increases the risk of enlarged prostate and prostate cancer.

Zinc is also a vital mineral in the forming of stomach acid, decreasing the chance of malabsorption syndrome.

5. Iron
Deficiency of iron not only causes anemia but also decreases the production of red blood cells resulting of the depletion of oxygen circulated in the bloodstream, weakening the immune system and increasing the risk of inflammation and chronic diseases.

6. Vitamin K
Vitamin K found abundant in broccoli, cauliflower, cabbage, kale, kohlrabi, and Brussels sprouts, is an essential vitamin needed to underline skin membrane.

Without vitamin K our skin becomes less elastic, dry, leading to increased risk of forming skin free radicals, wrinkles and skin diseases.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Kyle J. Norton(Scholar, Master of Nutrition, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Tuesday, August 28, 2018

The Secrets of Vitamin(1) in Restored and Increased Collagen Production in Responsible for Wrinkle Effacement, Scientists Revealed

Skin aging is one of most visible ageing process which occurs constantly in our skin organ.

According to the Clinical Centre of Nis, certain plant extracts may have the ability to scavenge free radicals, protect the skin matrix through inhibition of enzymatic degradation by promoting collagen synthesis in skin elasticity and tightness(a).

Other suggested that reactive oxygen species induced domino effects in production of more free radicals, which can react with DNA, proteins, and fatty acids, causing oxidative damage and impairment of antioxidant system, leading to injuries and damage regulation pathways of skin, in initiated skin aging including wrinkles, roughness, appearance of fine lines, lack of elasticity, and de- or hyperpigmentation marks(b).

Vitamin A is a general term of Vitamin A Retinol, retinal, beta-carotene, alpha-carotene, gamma-carotene, and beta-cryptoxanthin best known for its functions in vision health and antioxidant scavenging and growth and differentiation of a number of cells and tissues.

1. Retinols
Activation of both all-trans retinoic acid and 9-cis retinoic acid in nuclear retinoic acid receptors (RARα, RARβ, and RARγ), may associate to reduction of skin aging(1).

In chronologically aged and photoaged human skin due to alternation of connective tissue collagen, caused by cysteine-rich protein 61(2) (CCN1, a negative regulator of collagen homeostasis), application of all-trans retinoic acid (RA), the major bioactive form of vitamin A significantly increased type I procollagen and reduced collagenase (matrix metalloproteinases-1, MMP-1)and suppressed recombinant human CCN1(3).

P-Dodecylaminophenol derived from the synthetic retinoid, in the skin of hairless mice study, exhibited the increase of cytokeratin 16 expression which is essential in skin healing and maintenance, without causing the desquamation and erythema(4).

In a vivo study to assess major aging signs and performing three-dimensional profilometry and digital imaging during a 9-month double-blind placebo-control involving 48 volunteers, researchers found that topical application of a ROL-containing product not only improves all major aging signs including wrinkles under the eyes, fine lines and tone evenness, but also promotes keratinocyte proliferation, induced epidermal thickening and alleviated skin aging signs, without any significant adverse reaction(5).

Retinyl retinoate 1, another synthetic version of retinols, showed inhibitory activity against c-Jun superior effects in compared to retinol on collagen synthesis.

Retinyl retinoate 1 may have the potential to be conveniently used as an additive in cosmetics for prevention and improvement of skin aging and medicines for the treatment of skin troubles(6).

Some researchers suggested that topical retinol improves fine wrinkles associated with natural aging, through its effects in induction of glycosaminoglycan in increased collagen production in responsible for wrinkle effacement.

Others insisted that retinol-treated aged skin is more likely to withstand skin injury and ulcer formation along with improved appearance(7).

Application of a stabilized 0.1% retinol-containing moisturizer showed the improving lines and wrinkles, pigmentation, elasticity, firmness and overall photodamage(8). N-retinoyl-D-glucosamine, a retinoic acid agonist in the study in comparison with retinol acid, showed the same effective of both in complete disappearance of the wrinkles caused by UVB irradiation probably via RAR transactivation activity, but the synthetic agonist showed no adverse effect in causing skin irritation(9).

2. Carotenoids(beta-carotene, alpha-carotene, gamma-carotene and beta-cryptoxanthin) and Retinal Carotenoids.

Plant pigments, converted to vitamin A after intake, play an important role in prevention and treatment of some diseases through antioxidant effects.

Nutrition rich in carotenoids is best known to prevent cell damage, premature skin aging, and skin cancer(10).

Carotenoids possess potent anti-oxidant properties and widely used in the skin care industry either as topically applied agents or oral supplements in an attempt to prolong youthful skin appearance(11)(12).

In free radicals cause of premature skin aging and lead to immunosuppression and the formation of skin diseases, scientists indicated that administration of carotenoids may interact with free radicals to protective system against destructive skin(13).

Other studies suggested that stress factors such as illness, UV and IR radiation of the sun, and smoking and alcohol consumption reduce the concentration of the carotenoids in the skin of that lead to deeper and denser of the furrows and wrinkles(14).

The testing of high doses of sun-emitted UV-radiation induced reactive oxygen species (ROS) in development of premature skin aging, injection of carotenoid-tablets combined with placebo-cream in induced less carotenoid accumulation than carotenoid-tablets alone(15).

In contrast to topical application, the systemically applied carotenoids are stored in the body fat tissue and slowly released onto the skin surface with sweat and sebum.

Application of retinaldehyde (RAL) showed a significant improvement of wrinkles(forehead wrinkles, nasolabial folds, crow’s feet and perioral wrinkles)(16).

In fact, deficiency of vitamin A may result in premature aging.

In skin of streptozotocin (STZ)-induced type 1 diabetic rats, researchers showed that vitamin A treated mice improves the production of collagen in dermis, cell growth and epidermal differentiation in skin tissues(17).

Taken altogether, vitamin A and its variants are found to be effective in prevention of skin damage and skin aging caused by over expression of type I procollagen and under expression of collagenase (matrix metalloproteinases-1, MMP-1).

Recommended intakes of vitamin A, according to the Institute of Medicine of the National Academies (formerly National Academy of Sciences) is 600 µg daily as extremely high doses (>9000 mg) can be toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

References
(a) Skin ageing: natural weapons and strategies by Binic I1, Lazarevic V, Ljubenovic M, Mojsa J, Sokolovic D.(PubMed)
(b) Phytoconstituents as photoprotective novel cosmetic formulations by Saraf S1, Kaur CD.(PubMed)
(1) 40 years of topical tretinoin use in review by Baldwin HE1, Nighland M, Kendall C, Mays DA, Grossman R, Newburger J.(PubMed)
(2) Elevated cysteine-rich 61 mediates aberrant collagen homeostasis in chronologically aged and photoaged human skin by Quan T1, He T, Shao Y, Lin L, Kang S, Voorhees JJ, Fisher GJ.(PubMed)
(3) Retinoids suppress cysteine-rich protein 61 (CCN1), a negative regulator of collagen homeostasis, in skin equivalent cultures and aged human skin in vivo by Quan T1, Qin Z, Shao Y, Xu Y, Voorhees JJ, Fisher GJ(PubMed)
(4) Effects of the aminophenol analogue p-Dodecylaminophenol on mouse skin by Takahashi N1, Fujiu Y(PubMed)
(5) Antiaging action of retinol: from molecular to clinical by Bellemère G1, Stamatas GN, Bruère V, Bertin C, Issachar N, Oddos T.(PubMed)
(6) Synthesis and in vitro biological activity of retinyl retinoate, a novel hybrid retinoid derivative by Kim H1, Kim B, Kim H, Um S, Lee J, Ryoo H, Jung H(PubMed)
(7) Improvement of naturally aged skin with vitamin A (retinol) by Kafi R1, Kwak HS, Schumacher WE, Cho S, Hanft VN, Hamilton TA, King AL, Neal JD, Varani J, Fisher GJ, Voorhees JJ, Kang S.(PubMed)
(8) A stabilized 0.1% retinol facial moisturizer improves the appearance of photodamaged skin in an eight-week, double-blind, vehicle-controlled study by Tucker-Samaras S1, Zedayko T, Cole C, Miller D, Wallo W, Leyden JJ.(PubMed)
(9) N-retinoyl-D-glucosamine, a new retinoic acid agonist, mediates topical retinoid efficacy with no irritation on photoaged skin by Kambayashi H1, Odake Y, Takada K, Funasaka Y, Ichihashi M, Kato S(PubMed)
(10) Influence of dietary carotenoids on radical scavenging capacity of the skin and skin lipids by Meinke MC1, Friedrich A, Tscherch K, Haag SF, Darvin ME, Vollert H, Groth N, Lademann J, Rohn S.(PubMed)
(11) Discovering the link between nutrition and skin aging by Schagen SK1, Zampeli VA, Makrantonaki E, Zouboulis CC.(PubMed)
(12) The role of nutraceuticals in anti-aging medicine by Vranesić-Bender D.(PubMed)
(13) Interaction between carotenoids and free radicals in human skin by Lademann J1, Schanzer S, Meinke M, Sterry W, Darvin ME(PubMed)
(14) Carotenoids in human skin by Lademann J1, Meinke MC, Sterry W, Darvin ME(PubMed)
(15) Dermal carotenoid level and kinetics after topical and systemic administration of antioxidants: enrichment strategies in a controlled in vivo study by Darvin ME1, Fluhr JW, Schanzer S, Richter H, Patzelt A, Meinke MC, Zastrow L, Golz K, Doucet O, Sterry W, Lademann J(PubMed)
(16) Retinaldehyde/hyaluronic acid fragments: a synergistic association for the management of skin aging by Cordero A1, Leon-Dorantes G, Pons-Guiraud A, Di Pietro A, Asensi SV, Walkiewicz-Cyraska B, Litvik R, Turlier V, Mery S, Merial-Kieny C(PubMed)
(17) A close relationship between type 1 diabetes and vitamin A-deficiency and matrix metalloproteinase and hyaluronidase activities in skin tissues by Takahashi N1, Takasu S.(PubMed)

Pages

Natural Medicine for Fatty Liver And Obesity Reversal